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Pak-Leong Lim

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Jusak Nugraha; Frankie C H Tam; Ferdy R Marpaung; Pak-Leong Lim
Microbiological culture simplified using anti-O12 monoclonal antibody in TUBEX test to detect Salmonella bacteria from blood culture broths of enteric fever patients.
Meiying Yan; Frankie C H Tam; Biao Kan; Pak-Leong Lim
Combined rapid (TUBEX) test for typhoid-paratyphoid A fever based on strong anti-O12 response: design and critical assessment of sensitivity.
Frankie Chi-Hang Tam; Danny T M Leung; C H Ma; Pak-Leong Lim
Modification of the TUBEX typhoid test to detect antibodies directly from haemolytic serum and whole blood.

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All Publications

2012: Jusak Nugraha; Frankie C H Tam; Ferdy R Marpaung; Pak-Leong Lim
Microbiological culture simplified using anti-O12 monoclonal antibody in TUBEX test to detect Salmonella bacteria from blood culture broths of enteric fever patients.
PloS one 2012;7(11):e49586.
2011: Meiying Yan; Frankie C H Tam; Biao Kan; Pak-Leong Lim
Combined rapid (TUBEX) test for typhoid-paratyphoid A fever based on strong anti-O12 response: design and critical assessment of sensitivity.
PloS one 2011;6(9):e24743.
2008: Frankie Chi-Hang Tam; Danny T M Leung; C H Ma; Pak-Leong Lim
Modification of the TUBEX typhoid test to detect antibodies directly from haemolytic serum and whole blood.
Journal of medical microbiology 2008;57(Pt 11):1349-53.
2008: Frankie Chi-Hang Tam; Mingliu Wang; Baiqing Dong; Danny T M Leung; Chun Hung Ma; Pak-Leong Lim
New rapid test for paratyphoid a fever: usefulness, cross-detection, and solution.
Diagnostic microbiology and infectious disease 2008;62(2):142-50.
2008: Haitao Niu; Danny T M Leung; Chun Hung Ma; Eric C Y Law; Frankie C H Tam; Pak-Leong Lim
Cells that produce deleterious autoreactive antibodies are vulnerable to suicide.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2246-57.
2008: Frankie C H Tam; Thomas K W Ling; Kam Tak Wong; Danny T M Leung; Raphael C Y Chan; Pak-Leong Lim
The TUBEX test detects not only typhoid-specific antibodies but also soluble antigens and whole bacteria.
Journal of medical microbiology 2008;57(Pt 3):316-23.
2008: Ben Chung-Lap Chan; Arthur Kar-Keung Ching; Ka-Fai To; J C-K Leung; Shiuan Chen; Qing Li; P B-S Lai; Nelson Tang; P-C Shaw; J Y-H Chan; Anthony Edward James; K-N Lai; Pak-Leong Lim; K K-H Lee; Yiu Loon Chui
BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma.
Oncogene 2008;27(9):1208-17.
2007: Mahbubur Rahman; A Kasem Siddique; Frankie Chi-Hang Tam; Sabrina Sharmin; Harunur Rashid; Anwarul Iqbal; Sirajuddin Ahmed; Gopinath Balkrish Nair; Claire-Lise Chaignat; Pak-Leong Lim
Rapid detection of early typhoid fever in endemic community children by the TUBEX O9-antibody test.
Diagnostic microbiology and infectious disease 2007;58(3):275-81.
2007: Frankie Chi-Hang Tam; Chun Hung Ma; Danny T M Leung; Brian Sutton; Pak-Leong Lim
Carrier-specificity of a phosphorylcholine-binding antibody requires the presence of the constant domains and is not dependent on the unique VH49 glycine or VH30 threonine residues.
Journal of immunological methods 2007;321(1-2):152-63.
2006: Danny T M Leung; W W C van Maren; F K L Chan; Wai S Chan; Anthony W I Lo; Chun Hung Ma; Frankie Chi-Hang Tam; Ka-Fai To; Paul K S Chan; J J Y Sung; Pak-Leong Lim
Extremely low exposure of a community to severe acute respiratory syndrome coronavirus: false seropositivity due to use of bacterially derived antigens.
Journal of virology 2006;80(18):8920-8.
2006: Pak-Leong Lim; Moncef Zouali
Pathogenic autoantibodies: emerging insights into tissue injury.
Immunology letters 2006;103(1):17-26.
2005: Paul K S Chan; Pak-Leong Lim; Esther Y M Liu; Jo L K Cheung; Danny T M Leung; Joseph J Y Sung
Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection.
The Journal of infectious diseases 2005;192(1):166-9.
2005: Paul K S Chan; Esther Y M Liu; Danny T M Leung; Jo L K Cheung; Chun Hung Ma; Frankie Chi-Hang Tam; Mamie Hui; John S Tam; Pak-Leong Lim
Evaluation of a recombinant nucleocapsid protein-based assay for anti-SARS-CoV IgG detection.
Journal of medical virology 2005;75(2):181-4.
2005: Ben Chung-Lap Chan; Qing Li; Stephanie Ka-Yee Chow; Arthur Kar-Keung Ching; Choong-Tsek Liew; Pak-Leong Lim; Kenneth Ka-Ho Lee; John Yeuk-Hon Chan; Yiu Loon Chui
BRE enhances in vivo growth of tumor cells.
Biochemical and biophysical research communications 2005;326(2):268-73.
2005: Danny T M Leung; Chun Hung Ma; Haitao Niu; Choong-Tsek Liew; Janet Tsui-Ying Tang; Pak-Leong Lim
Nuclear telomerase is less accessible to antibody probing than known nuclear antigens: retrieval with new immunostaining buffer.
Histochemistry and cell biology 2005;123(1):105-12.
2004: Qing Li; Arthur Kar-Keung Ching; Ben Chung-Lap Chan; Stephanie Ka-Yee Chow; Pak-Leong Lim; Tony Cheong-Yip Ho; Wai-Ki Ip; Chun Kwok Wong; Christopher Wai-Kei Lam; Kenneth Ka-Ho Lee; John Yeuk-Hon Chan; Yiu Loon Chui
A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.
The Journal of biological chemistry 2004;279(50):52106-16.
2004: Danny T M Leung; Frankie Chi-Hang Tam; Chun Hung Ma; Paul K S Chan; Jo L K Cheung; Haitao Niu; John S Tam; Pak-Leong Lim
Antibody response of patients with severe acute respiratory syndrome (SARS) targets the viral nucleocapsid.
The Journal of infectious diseases 2004;190(2):379-86.
2004: Chun Hung Ma; Joannie Hui; Janet Tsui Ying Tang; Danny T M Leung; Yiu Loon Chui; Tai Fai Fok; Pak-Leong Lim
Antibodies to guanosine triphosphate misidentified as anti-double-stranded DNA antibodies in a patient with antinuclear antibody-negative lupus, due to buckling of insolubilized assay DNA.
Arthritis and rheumatism 2004;50(5):1533-8.
2004: E M C Lau; Samuel Wong; Martin Li; Chun Hung Ma; Pak-Leong Lim; Jean Woo
Osteoporosis and transforming growth factor-beta-1 gene polymorphism in Chinese men and women.
Journal of bone and mineral metabolism 2004;22(2):148-52.
2003: Frankie Chi-Hang Tam; Pak-Leong Lim
The TUBEX typhoid test based on particle-inhibition immunoassay detects IgM but not IgG anti-O9 antibodies.
Journal of immunological methods 2003;282(1-2):83-91.
2003: Arthur Kar-Keung Ching; Qing Li; Pak-Leong Lim; John Yeuk-Hon Chan; Yiu Loon Chui
Expression of a conserved mouse stress-modulating gene, Bre: comparison with the human ortholog.
DNA and cell biology 2003;22(8):497-504.
2002: Ben Chung-Lap Chan; Ka-Fai To; Jesse C S Pang; Yuk Fei Chung; Kwok-Wai Lo; Joanna H M Tong; Dolly Wai Sin Huang; Pak-Leong Lim; Yiu Loon Chui
Generation of monoclonal antibodies against Hong Kong nasopharyngeal carcinoma-associated Epstein-Barr virus latent membrane protein 1 (LMP1).
International journal of cancer. Journal international du cancer 2002;102(5):492-8.
2002: Kwok-Man Poon; Frankie Chi-Hang Tam; Yiu Loon Chui; Pak-Leong Lim
Single-chain Fv fragment lacks carrier specificity of the native antibody.
Molecular immunology 2002;39(1-2):19-24.
2001: Arthur Kar-Keung Ching; P S Li; Qing Li; Ben Chung-Lap Chan; John Yeuk-Hon Chan; Pak-Leong Lim; Jesse C S Pang; Yiu Loon Chui
Expression of human BRE in multiple isoforms.
Biochemical and biophysical research communications 2001;288(3):535-45.
2001: H L Wun; Danny T M Leung; KC Wong; Yiu Loon Chui; Pak-Leong Lim
Molecular mimicry: anti-DNA antibodies may arise inadvertently as a response to antibodies generated to microorganisms.
International immunology 2001;13(9):1099-107.
2000: Danny T M Leung; N W Yam; Yiu Loon Chui; KC Wong; Pak-Leong Lim
A human and a mouse anti-idiotypic antibody specific for human T14(+) anti-DNA antibodies reconstructed by phage display.
Gene 2000;255(2):373-80.
2000: Arthur Kar-Keung Ching; P S Li; W Y Chan; C H Ma; S S Lee; Pak-Leong Lim; Yiu Loon Chui
Strand bias in Ig somatic hypermutation is determined by signal sequence within the variable region.
International immunology 2000;12(9):1245-53.
2000: K W Chan; Pak-Leong Lim; Frankie Chi-Hang Tam; Edmund T S Li; Boon L Lim
Isolation of leptin-binding peptides from a random peptide phage library.
The journal of peptide research : official journal of the American Peptide Society 2000;55(4):318-24.
1998: Pak-Leong Lim; Frankie Chi-Hang Tam; YM Cheong; M Jegathesan
One-step 2-minute test to detect typhoid-specific antibodies based on particle separation in tubes.
Journal of clinical microbiology 1998;36(8):2271-8.
1997: Pak-Leong Lim; Frankie Chi-Hang Tam; Yiu Loon Chui; L W Ng
Identification of a surrogate TSL-1 antigen of Trichinella spiralis from a phage library of random peptides.
Parasite immunology 1997;19(6):281-6.
1997: V K Poon; Yiu Loon Chui; Pak-Leong Lim
Phage-displayed La/SS-B antigen as a diagnostic reagent.
Immunotechnology : an international journal of immunological engineering 1997;3(2):155-9.
1997: Pak-Leong Lim; Danny T M Leung; L W Ng; KC Wong; S Y Song; Yiu Loon Chui; J C Leung; K N Lai; S F Lui
An anti-idiotypic (T14) antibody found commonly in patients with systemic lupus erythematosus that may be pathogenic.
Annals of the New York Academy of Sciences 1997;815():462-4.
1997: Angela KF Lo; A K Ching; Pak-Leong Lim; Yiu Loon Chui
Strand breaks in immunoglobulin gene hypermutation.
Annals of the New York Academy of Sciences 1997;815():432-5.
1996: Pak-Leong Lim; L W Ng; D T Leung; K C Wong; S Y Song; Yiu Loon Chui; J C Leung; K N Lai; S F Lui
Common occurrence of an antiidiotypic antibody that recognizes T14+ anti-DNA antibodies in patients with systemic lupus erythematosus.
Arthritis and rheumatism 1996;39(12):1980-9.
1994: Pak-Leong Lim; D T Leung; Yiu Loon Chui; C H Ma
Structural analysis of a phosphorylcholine-binding antibody which exhibits a unique carrier specificity for Trichinella spiralis.
Molecular immunology 1994;31(14):1109-16.
1994: K N Lai; R T Ho; Joseph C K Leung; Yiu Loon Chui; Pak-Leong Lim; Siu-Fai Lui; Philip Kam-Tao Li
CD4-positive cells from patients with IgA nephropathy demonstrate increased mRNA of cytokines that induce the IgA switch and differentiation.
The Journal of pathology 1994;174(1):13-22.
1994: Pak-Leong Lim; W F Choy; S T Chan; D T Leung; S S Ng
Transgene-encoded antiphosphorylcholine (T15+) antibodies protect CBA/N (xid) mice against infection with Streptococcus pneumoniae but not Trichinella spiralis.
Infection and immunity 1994;62(5):1658-61.
1994: Pak-Leong Lim; S T Chan; D T Leung; S S Ng; T T Loh
Production of anti-phosphorylcholine antibodies of the T15 idiotype in CBA/N xid mice: investigation of the defect using a T15 immunoglobulin transgene.
Molecular immunology 1994;31(5):351-9.
1994: D T Leung; T T Loh; Pak-Leong Lim
The antigen-specific immunoglobulin G receptor is more sensitive to stimulation than the IgM receptor in transfected B cells.
Molecular immunology 1994;31(5):343-9.
1994: Pak-Leong Lim; Y L Lau
Occurrence of IgG subclass antibodies to ovalbumin, avidin, and pneumococcal polysaccharide in children.
International archives of allergy and immunology 1994;104(2):137-43.
1993: W Keung Leung; E Theilade; M B Comfort; Pak-Leong Lim
Microbiology of the pericoronal pouch in mandibular third molar pericoronitis.
Oral microbiology and immunology 1993;8(5):306-12.
1991: W F Choy; M H Ng; Pak-Leong Lim
Trichinella spiralis: light microscope monoclonal antibody localization and immunochemical characterization of phosphorylcholine and other antigens in the muscle larva.
Experimental parasitology 1991;73(2):172-83.
1990: Pak-Leong Lim; K H Ko
A tube latex test based on colour separation for the detection of IgM antibodies to either one of two different microorganisms.
Journal of immunological methods 1990;135(1-2):9-14.
1990: Pak-Leong Lim
A one-step two-particle latex immunoassay for the detection of Salmonella typhi endotoxin.
Journal of immunological methods 1990;135(1-2):257-61.
1990: Pak-Leong Lim; W F Choy
A thymus-independent (type 1) phosphorylcholine antigen isolated from Trichinella spiralis protects mice against pneumococcal infection.
Immunology 1990;69(3):443-8.
1989: W F Choy; Pak-Leong Lim; M H Ng
A rapid method for detecting Trichinella spiralis larvae in pork using a monoclonal antibody-latex conjugate.
Veterinary parasitology 1989;32(4):301-10.
1989: Pak-Leong Lim; K H Ko; W F Choy
A two-particle turbidometric latex immunoassay for the detection of specific IgM antibodies.
Journal of immunological methods 1989;117(2):267-73.
1989: Pak-Leong Lim; W F Choy
An improved latex agglutination-inhibition test for the detection of human chorionic gonadotropin in urine.
Journal of immunological methods 1989;117(1):137-9.
1988: Pak-Leong Lim; W F Choy
A spectrophotometric method for evaluating a latex agglutination assay of Salmonella typhi lipopolysaccharide.
Journal of immunological methods 1988;115(2):269-74.
1988: W F Choy; Pak-Leong Lim; M H Ng
A comparison of immunological methods for the detection of Trichinella spiralis antigen.
Journal of immunological methods 1988;113(1):17-24.
1986: Pak-Leong Lim; W F Choy
Monoclonal IgM/A hybrid antibodies: artifacts due to anti-idiotype (T15) antibodies in commercial anti-alpha sera.
Molecular immunology 1986;23(8):909-16.