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Wee Guan Lim

Research Profile

Chemicals & Drugs

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Publications

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Wee Guan Lim; Xiao Chen; Jun-Ping Liu; Bee Jen Tan; Shufeng Zhou; Adam Smith; Nathaniel Lees; Liansheng Hou; Fukang Gu; Xi-Yong Yu; Yaomin Du; Derek Smith; Chandra Verma; Ke Liu; Wei Duan
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
Sui Sum Yeong; Yimin Zhu; Derek Smith; Chandra Verma; Wee Guan Lim; Bee Jen Tan; Qiu-Tian Li; Nam Sang Cheung; Minnie Cai; Yi-Zhun Zhu; Shu-Feng Zhou; Seng-Lai Tan; Wei Duan
The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha.
Wee Guan Lim; Bee Jen Tan; Yimin Zhu; Shufeng Zhou; Jeffrey S Armstrong; Qiu-Tian Li; Qihan Dong; Eli Chan; Derek Smith; Chandra Verma; Seng-Lai Tan; Wei Duan
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.

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All Publications

2008: Wee Guan Lim; Xiao Chen; Jun-Ping Liu; Bee Jen Tan; Shufeng Zhou; Adam Smith; Nathaniel Lees; Liansheng Hou; Fukang Gu; Xi-Yong Yu; Yaomin Du; Derek Smith; Chandra Verma; Ke Liu; Wei Duan
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
Archives of biochemistry and biophysics 2008;479(2):170-8.
2006: Sui Sum Yeong; Yimin Zhu; Derek Smith; Chandra Verma; Wee Guan Lim; Bee Jen Tan; Qiu-Tian Li; Nam Sang Cheung; Minnie Cai; Yi-Zhun Zhu; Shu-Feng Zhou; Seng-Lai Tan; Wei Duan
The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha.
The Journal of biological chemistry 2006;281(41):30768-81.
2006: Wee Guan Lim; Bee Jen Tan; Yimin Zhu; Shufeng Zhou; Jeffrey S Armstrong; Qiu-Tian Li; Qihan Dong; Eli Chan; Derek Smith; Chandra Verma; Seng-Lai Tan; Wei Duan
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.
Cellular signalling 2006;18(9):1473-81.
2006: Yimin Zhu; Derek Smith; Chandra Verma; Wee Guan Lim; Bee Jen Tan; Jeffrey S Armstrong; Shufeng Zhou; Eli Chan; Seng-Lai Tan; Yi-Zhun Zhu; Nam Sang Cheung; Wei Duan
The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1.
Cellular signalling 2006;18(6):807-18.
2005: Yimin Zhu; Wee Guan Lim; Bee Jen Tan; Tian Seng Teo; Wei Duan
Identification of an integral plasma membrane pool of protein kinase C in mammalian tissues and cells.
Cellular signalling 2005;17(9):1125-36.
2005: Wee Guan Lim; Yimin Zhu; Chern-Hoe Wang; Bee Jen Tan; Jeffrey S Armstrong; Terje Dokland; Hongyuan Yang; Yi-Zhun Zhu; Tian Seng Teo; Wei Duan
The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.
Cellular signalling 2005;17(9):1084-97.
2005: Yimin Zhu; Qihan Dong; Bee Jen Tan; Wee Guan Lim; Shufeng Zhou; Wei Duan
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals.
Cancer research 2005;65(11):4520-4.