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Luís Maurício Lima

Research Profile

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Physiology

Protein Folding

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Protein Denaturation

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Julio Benítez; Aline Cavalcanti de Queiroz; Hugo Cerecetto; Isabel Correia; Mercedes González; Luís Maurício T R Lima; Virtudes Moreno; João Costa Pessoa; Javier Varela; Magna S Alexandre-Moreira; Marina Amaral Alves; Eliezer J Barreiro; Dinorah Gambino
New oxidovanadium(IV) N-acylhydrazone complexes: promising antileishmanial and antitrypanosomal agents.
Luana Braga Pontes; Juliana Montani Raimundo; Roberto T Sudo; Fernanda Antunes; Eliezer J Barreiro; Luís Maurício T R Lima; Gisele Zapata-Sudo
Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound.
Daniela B B Trivella; Caio V dos Reis; Débora Foguel; Luís Maurício T R Lima; Igor Polikarpov
Flavonoid interactions with human transthyretin: combined structural and thermodynamic analysis.

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All Publications

2013: Julio Benítez; Aline Cavalcanti de Queiroz; Hugo Cerecetto; Isabel Correia; Mercedes González; Luís Maurício T R Lima; Virtudes Moreno; João Costa Pessoa; Javier Varela; Magna S Alexandre-Moreira; Marina Amaral Alves; Eliezer J Barreiro; Dinorah Gambino
New oxidovanadium(IV) N-acylhydrazone complexes: promising antileishmanial and antitrypanosomal agents.
European journal of medicinal chemistry 2013;62():20-7.
2012: Luana Braga Pontes; Juliana Montani Raimundo; Roberto T Sudo; Fernanda Antunes; Eliezer J Barreiro; Luís Maurício T R Lima; Gisele Zapata-Sudo
Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound.
Fundamental & clinical pharmacology 2012;26(6):690-700.
2012: Daniela B B Trivella; Caio V dos Reis; Débora Foguel; Luís Maurício T R Lima; Igor Polikarpov
Flavonoid interactions with human transthyretin: combined structural and thermodynamic analysis.
Journal of structural biology 2012;180(1):143-53.
2012: Gisele Zapata-Sudo; Jaqueline Soares da Silva; Eliezer J Barreiro; Luís Maurício T R Lima; Isabelle Karine da Costa Nunes; Luana Braga Pontes; Roberto T Sudo
Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model.
European journal of pharmacology 2012;690(1-3):176-82.
2012: Raquel de Oliveira Lopes; Eliezer J Barreiro; Fernando Q Cunha; Cleverton Kleiton F de Lima; Paulo Gustavo B D Nascimento; Nelilma Correia Romeiro; Ana Luisa Palhares de Miranda; Leandro Louback da Silva; Luís Maurício T R Lima
Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors.
European journal of medicinal chemistry 2012;54():264-71.
2012: Luiz Henrique Guerreiro; Daniel Da Silva; Wendell Girard-Dias; Camile Moreira Mascarenhas; Kildare Miranda; Eduardo Ricci-Junior; Mauro Sola-Penna; Luís Maurício T R Lima
Polymeric particles for the controlled release of human amylin.
Colloids and surfaces. B, Biointerfaces 2012;94():101-6.
2011: Natália V Casquilho; Débora S Faffe; Luís Maurício T R Lima; Mariana N Machado; Raquel M Soares; Samuel Santos Valença; João L C R Alves; Sandra Maria Feliciano de Oliveira Azevedo; Eliezer J Barreiro; Alysson R Carvalho; Giovanna Marcella Cavalcante Carvalho; Walter A Zin
LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by microcystin-LR.
Toxicon : official journal of the International Society on Toxinology 2011;58(2):195-201.
2011: Daniela B B Trivella; Mirela I Sairre; Débora Foguel; Luís Maurício T R Lima; Igor Polikarpov
The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition.
Journal of structural biology 2011;173(2):323-32.
2010: Leonardo de C Palmieri; Luís Maurício T R Lima; Juliana B B Freire; Lucas Bleicher; Igor Polikarpov; Fabio C L Almeida; Débora Foguel
Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.
The Journal of biological chemistry 2010;285(41):31731-41.
2010: Giovanna Marcella Cavalcante Carvalho; Vinícius R Oliveira; Raquel M Soares; Sandra Maria Feliciano de Oliveira Azevedo; Luís Maurício T R Lima; Eliezer J Barreiro; Samuel S Valença; Paulo H N Saldiva; Débora S Faffe; Walter A Zin
Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR?
Toxicon : official journal of the International Society on Toxinology 2010;56(4):604-12.
2010: Daniela B B Trivella; Lucas Bleicher; Leonardo de Castro Palmieri; Helton José Wiggers; Carlos Alberto Montanari; Jeffery W Kelly; Luís Maurício T R Lima; Débora Foguel; Igor Polikarpov
Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.
Journal of structural biology 2010;170(3):522-31.
2010: Jerson L Silva; Tuane C R G Vieira; Mariana P B Gomes; Ana Paula Ano Bom; Luís Maurício T R Lima; Mônica Freitas; Daniella Ishimaru; Yraima Cordeiro; Debora Foguel
Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins.
Accounts of chemical research 2010;43(2):271-9.
2010: Ana Carolina M Figueira; Luís Maurício T R Lima; Leonardo H F Lima; Americo T Ranzani; Guilherme dos Santos Mule; Igor Polikarpov
Recognition by the thyroid hormone receptor of canonical DNA response elements.
Biochemistry 2010;49(5):893-904.
2010: Luís Maurício T R Lima; Vivian de Almeida Silva; Leonardo de Castro Palmieri; Maria Clara B R Oliveira; Débora Foguel; Igor Polikarpov
Identification of a novel ligand binding motif in the transthyretin channel.
Bioorganic & medicinal chemistry 2010;18(1):100-10.
2009: Maria Letícia de Castro Barbosa; Gabriela Muniz de Albuquerque Melo; Yolanda Karla Cupertino da Silva; Raquel de Oliveira Lopes; Everton Tenório de Souza; Aline Cavalcanti de Queiroz; Salete Smaniotto; Magna Suzana Alexandre-Moreira; Eliezer J Barreiro; Luís Maurício T R Lima
Synthesis and pharmacological evaluation of N-phenyl-acetamide sulfonamides designed as novel non-hepatotoxic analgesic candidates.
European journal of medicinal chemistry 2009;44(9):3612-20.
2009: Daniella Ishimaru; Ana Paula D Ano Bom; Luís Maurício T R Lima; Pablo A Quesado; Marcos F C Oyama; Claudia V de Moura Gallo; Yraima Cordeiro; Jerson L Silva
Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.
Biochemistry 2009;48(26):6126-35.
2009: Luís Maurício T R Lima; Camila Franco Becker; Guilherme Menegon Giesel; Adriana Fonseca Marques; Maria Thereza Cargnelutti; Mario de Oliveira Neto; Robson Queiroz Monteiro; Hugo Verli; Igor Polikarpov
Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases.
Biochimica et biophysica acta 2009;1794(6):873-81.
2009: Adriana F Marques; Yraima Cordeiro; Jerson L Silva; Luís Maurício T R Lima
Enhanced prion protein stability coupled to DNA recognition and milieu acidification.
Biophysical chemistry 2009;141(2-3):135-9.
2009: Nelilma Romeiro; Ramon D F Leite; Luís Maurício T R Lima; Suzana V S Cardozo; Ana L P de Miranda; Carlos A M Fraga; Eliezer J Barreiro
Synthesis, pharmacological evaluation and docking studies of new sulindac analogues.
European journal of medicinal chemistry 2009;44(5):1959-71.
2009: Nelilma Correia Romeiro; Gabriela Aguirre; Paola Hernández; Mercedes González; Hugo Cerecetto; Ignacio Aldana; Silvia Pérez-Silanes; Antonio Monge; Eliezer J Barreiro; Luís Maurício T R Lima
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.
Bioorganic & medicinal chemistry 2009;17(2):641-52.
2008: Guilherme Menegon Giesel; Luís Maurício T R Lima; Joana Faber-Barata; Jorge A Guimarães; Hugo Verli
Characterization of the papillomavirus alpha(1)E2 peptide unfolded to folded transition upon DNA binding.
FEBS letters 2008;582(25-26):3619-24.
2008: Nelilma Romeiro; Carlos Mauricio R Sant'Anna; Luís Maurício T R Lima; Carlos A M Fraga; Eliezer J Barreiro
NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).
European journal of medicinal chemistry 2008;43(9):1918-25.
2008: Jerson L Silva; Luís Maurício T R Lima; Débora Foguel; Yraima Cordeiro
Intriguing nucleic-acid-binding features of mammalian prion protein.
Trends in biochemical sciences 2008;33(3):132-40.
2008: Luís Maurício T R Lima; Flávia S Frattani; Jean L Dos Santos; Helena C Castro; Carlos A M Fraga; Russolina B Zingali; Eliezer J Barreiro
Synthesis and anti-platelet activity of novel arylsulfonate--acylhydrazone derivatives, designed as antithrombotic candidates.
European journal of medicinal chemistry 2008;43(2):348-56.
2006: Luís Maurício T R Lima; Yraima Cordeiro; Luzineide W Tinoco; Adriana F Marques; Cristiano L P Oliveira; Srisailam Sampath; Ravindra Kodali; Gildon Choi; Débora Foguel; Iris Torriani; Byron Caughey; Jerson L Silva
Structural insights into the interaction between prion protein and nucleic acid.
Biochemistry 2006;45(30):9180-7.
2006: Francisco J R Sousa; Luís Maurício T R Lima; Ana B F Pacheco; Cristiano L P Oliveira; Iris Torriani; Darcy F Almeida; Débora Foguel; Jerson L Silva; Ronaldo Mohana-Borges
Tetramerization of the LexA repressor in solution: implications for gene regulation of the E.coli SOS system at acidic pH.
Journal of molecular biology 2006;359(4):1059-74.
2006: Joana Faber-Barata; Ronaldo Mohana-Borges; Luís Maurício T R Lima
Specificity in DNA recognition by a peptide from papillomavirus E2 protein.
FEBS letters 2006;580(8):1919-24.
2006: H S Campos; Debora G Xisto; M B G Oliveira; I Teixeira; Elnara M Negri; Thais Mauad; D Carnielli; Luís Maurício T R Lima; Eliezer J Barreiro; Débora S Faffe; Walter A Zin; José Roberto Lapa e Silva; Patricia R M Rocco
Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2006;39(2):283-7.
2005: Yraima Cordeiro; Julia Kraineva; Mariana P B Gomes; Marilene H Lopes; Vilma Martins; Luís Maurício T R Lima; Débora Foguel; Roland Winter; Jerson L Silva
The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation.
Biophysical journal 2005;89(4):2667-76.
2005: Julio Mignaco; Luís Maurício T R Lima; A Rosenthal; Débora Foguel; Jerson L Silva
Highlights of the 3rd International Conference on High Pressure Bioscience and Biotechnology.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2005;38(8):1147-55.
2005: Gilberto M Sperandio da Silva; Luís Maurício T R Lima; Carlos A M Fraga; Carlos Mauricio R Sant'Anna; Eliezer J Barreiro
The molecular basis for coxib inhibition of p38alpha MAP kinase.
Bioorganic & medicinal chemistry letters 2005;15(15):3506-9.
2005: Josiane Neves; Luís Maurício T R Lima; Carlos A M Fraga; Eliezer J Barreiro; Ana L P Miranda; Bruno L Diaz; Alex Balduino; Rodrigo de Azeredo Siqueira; Patrícia M R e Silva; Marco A Martins
Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats.
European journal of pharmacology 2005;511(2-3):219-27.
2005: Magna S Alexandre-Moreira; Christina M Takiya; Luciana Barros de Arruda; Bernardo M O Pascarelli; Rachel N Gomes; Hugo C Castro-Faria-Neto; Luís Maurício T R Lima; Eliezer J Barreiro
LASSBio-468: a new achiral thalidomide analogue which modulates TNF-alpha and NO production and inhibits endotoxic shock and arthritis in an animal model.
International immunopharmacology 2005;5(3):485-94.
2005: Alexandre L Machado; Luís Maurício T R Lima; João Xavier Araújo; Carlos A M Fraga; Vera Lucia G Koatz; Eliezer J Barreiro
Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(4):1169-72.
2005: Juliana Vaz Bevilaqua; Luís Maurício T R Lima; Aline Gomes Cunha; Eliezer J Barreiro; Tito L M Alves; Lucia Moreira Campos Paiva; Denise M G Freire
Hydrolysis of new phthalimide-derived esters catalyzed by immobilized lipase.
Applied biochemistry and biotechnology 2005;121-124():117-28.
2005: Luís Maurício T R Lima; Eliezer J Barreiro
Bioisosterism: a useful strategy for molecular modification and drug design.
Current medicinal chemistry 2005;12(1):23-49.
2004: Luís Maurício T R Lima; Jerson L Silva
Positive contribution of hydration on DNA binding by E2c protein from papillomavirus.
The Journal of biological chemistry 2004;279(46):47968-74.
2004: Daniella Ishimaru; Luís Maurício T R Lima; Lenize F Maia; Priscila M Lopez; Ana P Ano Bom; Ana Paula Valente; Jerson L Silva
Reversible aggregation plays a crucial role on the folding landscape of p53 core domain.
Biophysical journal 2004;87(4):2691-700.
2004: Luís Maurício T R Lima; Russolina B Zingali; Débora Foguel; Robson Q Monteiro
New insights into conformational and functional stability of human alpha-thrombin probed by high hydrostatic pressure.
European journal of biochemistry / FEBS 2004;271(17):3580-7.
2004: Yraima Cordeiro; Julia Kraineva; Revanur Ravindra; Luís Maurício T R Lima; Mariana P B Gomes; Débora Foguel; Roland Winter; Jerson L Silva
Hydration and packing effects on prion folding and beta-sheet conversion. High pressure spectroscopy and pressure perturbation calorimetry studies.
The Journal of biological chemistry 2004;279(31):32354-9.
2004: Yraima Cordeiro; Luís Maurício T R Lima; Mariana P B Gomes; Débora Foguel; Jerson L Silva
Modulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).
The Journal of biological chemistry 2004;279(7):5346-52.
2003: Patricia R M Rocco; Denise Momesso; R C Figueira; Halina C Ferreira; R A Cadete; A Légora-Machado; Vera Lucia G Koatz; Luís Maurício T R Lima; Eliezer J Barreiro; Walter A Zin
Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(1):20-7.
2003: Marisa C Suarez; Cosme José V Machado; Luís Maurício T R Lima; Lawrence B Smillie; Joyce R Pearlstone; Jerson L Silva; Martha M Sorenson; Débora Foguel
Role of hydration in the closed-to-open transition involved in Ca2+ binding by troponin C.
Biochemistry 2003;42(18):5522-30.
2002: Luís Maurício T R Lima; Paulo Castro; Alexandre L Machado; Carlos A M Fraga; Lugnier Claire; Vera Lúcia Gonçalves de Moraes; Eliezer J Barreiro
Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues.
Bioorganic & medicinal chemistry 2002;10(9):3067-73.
2002: Luís Maurício T R Lima; Fernanda C F de Brito; Simone D de Souza; Ana L P Miranda; Carlos R Rodrigues; Carlos A M Fraga; Eliezer J Barreiro
Novel phthalimide derivatives, designed as leukotriene D(4) receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(11):1533-5.
2002: Jerson L Silva; Andréa C Oliveira; Andre M O Gomes; Luís Maurício T R Lima; Ronaldo Mohana-Borges; Ana B F Pacheco; Débora Foguel
Pressure induces folding intermediates that are crucial for protein-DNA recognition and virus assembly.
Biochimica et biophysica acta 2002;1595(1-2):250-65.
2000: Luís Maurício T R Lima; Débora Foguel; Jerson L Silva
DNA tightens the dimeric DNA-binding domain of human papillomavirus E2 protein without changes in volume.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14289-94.
2000: Diego U Ferreiro; Luís Maurício T R Lima; Alejandro D Nadra; Leonardo G Alonso; Fernando A Goldbaum; Gonzalo De Prat-Gay
Distinctive cognate sequence discrimination, bound DNA conformation, and binding modes in the E2 C-terminal domains from prototype human and bovine papillomaviruses.
Biochemistry 2000;39(47):14692-701.
2000: Yu-Keung Mok; Leonardo G Alonso; Luís Maurício T R Lima; Mark Bycroft; Gonzalo De Prat-Gay
Folding of a dimeric beta-barrel: residual structure in the urea denatured state of the human papillomavirus E2 DNA binding domain.
Protein science : a publication of the Protein Society 2000;9(4):799-811.
2000: AP Almeida; Silvia A G Da Silva; Maisa L S Souza; Luís Maurício T R Lima; Bartira Rossi-Bergmann; V L de Moraes; Sônia S Costa
Isolation and chemical analysis of a fatty acid fraction of Kalanchoe pinnata with a potent lymphocyte suppressive activity.
Planta medica 2000;66(2):134-7.
2000: Patricia C Lima; Luís Maurício T R Lima; K C da Silva; P H Léda; Ana L P de Miranda; Carlos A M Fraga; Eliezer J Barreiro
Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole.
European journal of medicinal chemistry 2000;35(2):187-203.
1999: Luís Maurício T R Lima; C B Ormelli; F F Brito; Ana L P Miranda; Carlos A M Fraga; Eliezer J Barreiro
Synthesis and antiplatelet evaluation of novel aryl-sulfonamide derivatives, from natural safrole.
Pharmaceutica acta Helvetiae 1999;73(6):281-92.
1997: Luís Maurício T R Lima; Gonzalo De Prat-Gay
Conformational changes and stabilization induced by ligand binding in the DNA-binding domain of the E2 protein from human papillomavirus.
The Journal of biological chemistry 1997;272(31):19295-303.