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Walt Lima

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Dongbo Yu; Don W Cleveland; Stanley T Crooke; Holly B Kordasiewicz; Walt F Lima; Jing Liu; Hannah Pendergraff; Thazha P Prakash; Eric E Swayze; David R Corey
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Walt F Lima; Heather M Murray; Susan F Murray; Thazha P Prakash; Punit P Seth; Eric E Swayze; Hans Gaus; Garth A Kinberger; Cheryl S Li; Wenyu Li; Alfred E Chappell; Stanley T Crooke
Single-stranded siRNAs activate RNAi in animals.
Timothy A Vickers; Walt F Lima; Hongjiang Wu; Josh G Nichols; Peter Linsley; Stanley T Crooke
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.

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All Publications

2012: Dongbo Yu; Don W Cleveland; Stanley T Crooke; Holly B Kordasiewicz; Walt F Lima; Jing Liu; Hannah Pendergraff; Thazha P Prakash; Eric E Swayze; David R Corey
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Cell 2012;150(5):895-908.
2012: Walt F Lima; Heather M Murray; Susan F Murray; Thazha P Prakash; Punit P Seth; Eric E Swayze; Hans Gaus; Garth A Kinberger; Cheryl S Li; Wenyu Li; Alfred E Chappell; Stanley T Crooke
Single-stranded siRNAs activate RNAi in animals.
Cell 2012;150(5):883-94.
2009: Timothy A Vickers; Walt F Lima; Hongjiang Wu; Josh G Nichols; Peter Linsley; Stanley T Crooke
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
Nucleic acids research 2009;37(20):6927-41.
2009: Walt F Lima; Hongjiang Wu; Josh G Nichols; Hong Sun; Heather M Murray; Stanley T Crooke
Binding and cleavage specificities of human Argonaute2.
The Journal of biological chemistry 2009;284(38):26017-28.
2009: Walt F Lima; Heather Murray; Josh G Nichols; Hongjiang Wu; Hong Sun; Thazha P Prakash; Andres R Berdeja; Hans J Gaus; Stanley T Crooke
Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.
The Journal of biological chemistry 2009;284(4):2535-48.
2007: Timothy A Vickers; Walt F Lima; Josh G Nichols; Stanley T Crooke
Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells.
Nucleic acids research 2007;35(19):6598-610.
2007: Walt F Lima; John B Rose; Josh G Nichols; Hongjiang Wu; Michael T Migawa; Tadeusz K Wyrzykiewicz; Andrew Siwkowski; Stanley T Crooke
Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.
Molecular pharmacology 2007;71(1):83-91.
2007: Walt F Lima; John B Rose; Josh G Nichols; Hongjiang Wu; Michael T Migawa; Tadeusz K Wyrzykiewicz; Guillermo Vasquez; Eric E Swayze; Stanley T Crooke
The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.
Molecular pharmacology 2007;71(1):73-82.
2006: Zhiwei Wang; Andrew Siwkowski; Walt F Lima; Phil Olsen; Vasulinga T Ravikumar
Antisense oligonucleotides: efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?
Bioorganic & medicinal chemistry 2006;14(14):5049-60.
2006: Erich Koller; Stephanie Propp; Heather Murray; Walt F Lima; Balkrishen Bhat; Thazha P Prakash; Charles R Allerson; Eric E Swayze; Eric G Marcusson; Nicholas Dean
Competition for RISC binding predicts in vitro potency of siRNA.
Nucleic acids research 2006;34(16):4467-76.
2004: Walt F Lima; Josh G Nichols; Hongjiang Wu; Thazha P Prakash; Michael T Migawa; Tadeusz K Wyrzykiewicz; Balkrishen Bhat; Stanley T Crooke
Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.
The Journal of biological chemistry 2004;279(35):36317-26.
2004: Hongjiang Wu; Walt F Lima; Hong Zhang; Amy Fan; Hong Sun; Stanley T Crooke
Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.
The Journal of biological chemistry 2004;279(17):17181-9.
2004: Vasulinga T Ravikumar; Walt F Lima; Kent Van Sooy; Brett Turney
Biologically active antisense phosphorothioate oligodeoxyribonucleotides: synthesis, characterization, and studies of 3'-terminal phosphorothioate monoester analogues.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):149-60.
2003: Walt F Lima; Hongjiang Wu; Josh G Nichols; Thazha P Prakash; Vasulinga T Ravikumar; Stanley T Crooke
Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.
The Journal of biological chemistry 2003;278(50):49860-7.
2003: Vasulinga T Ravikumar; Daniel C Capaldi; Walt F Lima; Elena Lesnik; Brett Turney; Douglas L Cole
Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis.
Bioorganic & medicinal chemistry 2003;11(21):4673-9.
2003: Walt F Lima; Hongjiang Wu; Josh G Nichols; Sherilynn M Manalili; Jared J Drader; Steven A Hofstadler; Stanley T Crooke
Human RNase H1 activity is regulated by a unique redox switch formed between adjacent cysteines.
The Journal of biological chemistry 2003;278(17):14906-12.
2001: Hongjiang Wu; Walt F Lima; Stanley T Crooke
Investigating the structure of human RNase H1 by site-directed mutagenesis.
The Journal of biological chemistry 2001;276(26):23547-53.
2001: Walt F Lima; Stanley T Crooke
Preparation and use of ZFY-6 zinc finger ribonuclease.
Methods in enzymology 2001;341():490-500.
2001: Walt F Lima; Hongjiang Wu; Stanley T Crooke
Human RNases H.
Methods in enzymology 2001;341():430-40.
1999: H Wu; Walt F Lima; Stanley T Crooke
Properties of cloned and expressed human RNase H1.
The Journal of biological chemistry 1999;274(40):28270-8.
1999: Walt F Lima; Stanley T Crooke
Highly efficient endonucleolytic cleavage of RNA by a Cys(2)His(2) zinc-finger peptide.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10010-5.
1998: H Wu; Walt F Lima; Stanley T Crooke
Molecular cloning and expression of cDNA for human RNase H.
Antisense & nucleic acid drug development 1998;8(1):53-61.
1998: H Wu; A R MacLeod; Walt F Lima; Stanley T Crooke
Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs.
The Journal of biological chemistry 1998;273(5):2532-42.
1997: Walt F Lima; Stanley T Crooke
Cleavage of single strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1.
The Journal of biological chemistry 1997;272(44):27513-6.
1997: Walt F Lima; V Mohan; Stanley T Crooke
The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity.
The Journal of biological chemistry 1997;272(29):18191-9.
1997: Walt F Lima; Stanley T Crooke
Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids.
Biochemistry 1997;36(2):390-8.