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Jen-Kun Lin

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Shih-Han Sun; Cheng Huang; Hsiu-Chen Huang; Jen-Kun Lin
Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin.
Yea-Tzy Deng; Ming-Shyue Lee; Tsai-Wen Chang; Jen-Kun Lin
Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells.
Kuo-Hui Lin; Ching-Yuan Lin; Chin-Chih Liu; Ming-Young Chou; Jen-Kun Lin
Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesis.

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All Publications

2012: Shih-Han Sun; Cheng Huang; Hsiu-Chen Huang; Jen-Kun Lin
Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin.
European journal of pharmacology 2012;690(1-3):22-30.
2012: Yea-Tzy Deng; Ming-Shyue Lee; Tsai-Wen Chang; Jen-Kun Lin
Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells.
Journal of agricultural and food chemistry 2012;60(4):1059-66.
2011: Kuo-Hui Lin; Ching-Yuan Lin; Chin-Chih Liu; Ming-Young Chou; Jen-Kun Lin
Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesis.
Journal of agricultural and food chemistry 2011;59(7):3420-8.
2011: Min-Hsiung Pan; Yin-Jen Wang; Yi-Siou Chiou; Chi-Tang Ho; Jen-Kun Lin
Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate.
Food & function 2011;2(2):101-10.
2010: Hsiu-Chen Huang; Kai-Yang Syu; Jen-Kun Lin
Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells.
Journal of agricultural and food chemistry 2010;58(15):8699-708.
2010: Yea-Tzy Deng; Hsiu-Chen Huang; Jen-Kun Lin
Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling.
Molecular carcinogenesis 2010;49(2):141-51.
2009: Erica P Cai; Jen-Kun Lin
Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells.
Journal of agricultural and food chemistry 2009;57(20):9817-27.
2009: Tzong-Der Way; Hui-Yi Lin; Daih-Huang Kuo; Shang-Jie Tsai; Jia-Ching Shieh; Jia-Chiun Wu; Maw-Rong Lee; Jen-Kun Lin
Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells.
Journal of agricultural and food chemistry 2009;57(12):5257-64.
2009: Hsiu-Chen Huang; Chien-Yu Huang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.
Molecular carcinogenesis 2009;48(6):517-31.
2009: Po-Tsun Kuo; Tsung-Pang Lin; Liang-Chih Liu; Chi-Hung Huang; Jen-Kun Lin; Jung-Yie Kao; Tzong-Der Way
Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression.
Journal of agricultural and food chemistry 2009;57(8):3331-9.
2009: Chih-Li Lin; Ta-Fu Chen; Ming-Jang Chiu; Tzong-Der Way; Jen-Kun Lin
Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.
Neurobiology of aging 2009;30(1):81-92.
2008: Hsiu-Chen Huang; Tzong-Der Way; Chih-Li Lin; Jen-Kun Lin
EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein.
Endocrinology 2008;149(12):5972-83.
2008: Sung-Ho Chen; Jen-Kun Lin; Yu-Chih Liang; MH Pan; Shing-Hwa Liu; Shoei-Yn Lin-Shiau
Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex.
European journal of pharmacology 2008;594(1-3):9-17.
2008: Kai-Yang Syu; Chih-Li Lin; Hsiu-Chen Huang; Jen-Kun Lin
Determination of theanine, GABA, and other amino acids in green, oolong, black, and Pu-erh teas with dabsylation and high-performance liquid chromatography.
Journal of agricultural and food chemistry 2008;56(17):7637-43.
2008: Chang-Mu Chen; Jen-Kun Lin; Shing-Hwa Liu; Shoei-Yn Lin-Shiau
Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity.
Journal of neuroscience research 2008;86(12):2696-704.
2008: Chih-Li Lin; Jen-Kun Lin
Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells.
Molecular nutrition & food research 2008;52(8):930-9.
2008: Feng-Lan Chiu; Jen-Kun Lin
Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages.
FEBS letters 2008;582(16):2407-12.
2008: Sung-Ho Chen; Jen-Kun Lin; Shing-Hwa Liu; Yu-Chih Liang; Shoei-Yn Lin-Shiau
Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(1):138-49.
2008: Feng-Lan Chiu; Jen-Kun Lin
Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts.
The Prostate 2008;68(1):61-71.
2007: Chun-Te Chiang; Tzong-Der Way; Shang-Jie Tsai; Jen-Kun Lin
Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.
FEBS letters 2007;581(30):5735-42.
2007: Chih-Li Lin; Hsiu-Chen Huang; Jen-Kun Lin
Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells.
Journal of lipid research 2007;48(11):2334-43.
2007: Wei-Jan Huang; Chih-Hsiang Huang; Chia-Li Wu; Jen-Kun Lin; Yue-Wen Chen; Chun-Liang Lin; Shuang-En Chuang; Chung-Yang Huang; Chia-Nan Chen
Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells.
Journal of agricultural and food chemistry 2007;55(18):7366-76.
2007: Chun-Te Chiang; Tzong-Der Way; Jen-Kun Lin
Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin.
Molecular cancer therapeutics 2007;6(7):2127-38.
2007: Min-Hsiung Pan; Cheng-Chan Lin; Jen-Kun Lin; Wei-Jen Chen
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.
Journal of agricultural and food chemistry 2007;55(13):5030-7.
2007: Meng-Shih Weng; Chiung-Ho Liao; Chiung-Nien Chen; Chia-Li Wu; Jen-Kun Lin
Propolin H from Taiwanese propolis induces G1 arrest in human lung carcinoma cells.
Journal of agricultural and food chemistry 2007;55(13):5289-98.
2007: Meng-Shih Weng; Chi-Tang Ho; Yuan-Soon Ho; Jen-Kun Lin
Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.
Toxicology and applied pharmacology 2007;218(2):107-18.
2007: Kuan-Hung Chen; Meng-Shih Weng; Jen-Kun Lin
Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells.
Biochemical pharmacology 2007;73(2):215-27.
2007: Chiung-Nien Chen; Chia-Li Wu; Jen-Kun Lin
Apoptosis of human melanoma cells induced by the novel compounds propolin A and propolin B from Taiwenese propolis.
Cancer letters 2007;245(1-2):218-31.
2007: Jen-Kun Lin
Molecular targets of curcumin.
Advances in experimental medicine and biology 2007;595():227-43.
2006: Kuo-Tai Hua; Tzong-Der Way; Jen-Kun Lin
Pentagalloylglucose inhibits estrogen receptor alpha by lysosome-dependent depletion and modulates ErbB/PI3K/Akt pathway in human breast cancer MCF-7 cells.
Molecular carcinogenesis 2006;45(8):551-60.
2006: Jen-Kun Lin; Shoei-Yn Lin-Shiau
Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols.
Molecular nutrition & food research 2006;50(2):211-7.
2005: Tzong-Der Way; Jen-Kun Lin
Role of HER2/HER3 co-receptor in breast carcinogenesis.
Future oncology (London, England) 2005;1(6):841-9.
2005: Kuei-Yao Hsu; Hwai-Jeng Lin; Jen-Kun Lin; Wein-Shung Kuo; Yueh-Hsing Ou
Mutagenicity study of butachlor and its metabolites using Salmonella typhimurium.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2005;38(6):409-16.
2005: Min-Hsiung Pan; Yi-Hong Sin; Ching-Shu Lai; Ying-Jan Wang; Jen-Kun Lin; Mingfu Wang; Chi-Tang Ho
Induction of apoptosis by 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione through reactive oxygen species production, GADD153 expression, and caspases activation in human epidermoid carcinoma cells.
Journal of agricultural and food chemistry 2005;53(23):9039-49.
2005: Feng-Lan Chiu; Jen-Kun Lin
HPLC analysis of naturally occurring methylated catechins, 3' '- and 4' '-methyl-epigallocatechin gallate, in various fresh tea leaves and commercial teas and their potent inhibitory effects on inducible nitric oxide synthase in macrophages.
Journal of agricultural and food chemistry 2005;53(18):7035-42.
2005: Chiung-Ho Liao; Shengmin Sang; Chi-Tang Ho; Jen-Kun Lin
Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells.
Journal of cellular biochemistry 2005;96(1):155-69.
2005: Yu-Wen Chen; Shiu-Chen Huang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1.
Carcinogenesis 2005;26(7):1296-306.
2005: Meng-Shih Weng; Yuan-Soon Ho; Jen-Kun Lin
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase.
Biochemical pharmacology 2005;69(12):1815-27.
2005: Yuan-Soon Ho; Chien-Ho Chen; Ying-Jan Wang; Richard G Pestell; Chris Albanese; Rong-Jane Chen; Mei-Chi Chang; Jiiang-Huei Jeng; Shyr-Yi Lin; Yu-Chih Liang; How Tseng; Wen-Sen Lee; Jen-Kun Lin; Jan-Show Chu; Li-Ching Chen; Chia-Hwa Lee; Wei-Ling Tso; Yann-Chwen Lai; Chih-Hsiung Wu
Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.
Toxicology and applied pharmacology 2005;205(2):133-48.
2005: Chiung-Ho Liao; Chi-Tang Ho; Jen-Kun Lin
Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes.
Biochemical and biophysical research communications 2005;329(4):1306-14.
2005: Kuan-Li Kuo; Meng-Shih Weng; Chun-Te Chiang; Yao-Jen Tsai; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats.
Journal of agricultural and food chemistry 2005;53(2):480-9.
2005: Shiu-Chen Huang; Chi-Tang Ho; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun.
Biochemical pharmacology 2005;69(2):221-32.
2005: Tzong-Der Way; Ming-Ching Kao; Jen-Kun Lin
Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells.
FEBS letters 2005;579(1):145-52.
2005: Chun-Te Chiang; Meng-Shih Weng; Shoei-Yn Lin-Shiau; Kuan-Li Kuo; Yao-Jen Tsai; Jen-Kun Lin
Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells.
Oncology research 2005;16(3):119-28.
2004: Chiung-Ho Liao; Shengmin Sang; Yu-Chih Liang; Chi-Tang Ho; Jen-Kun Lin
Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol.
Molecular carcinogenesis 2004;41(3):140-9.
2004: Ping-Chi Hsu; Ying-Tang Huang; Mei-Ling Tsai; Ying-Jan Wang; Jen-Kun Lin; Min-Hsiung Pan
Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells.
Journal of agricultural and food chemistry 2004;52(20):6330-7.
2004: Tzong-Der Way; Hung-Hsiao Lee; Ming-Ching Kao; Jen-Kun Lin
Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression.
European journal of cancer (Oxford, England : 1990) 2004;40(14):2165-74.
2004: Jen-Kun Lin
Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin.
Archives of pharmacal research 2004;27(7):683-92.
2004: Hung-Hsiao Lee; Chi-Tang Ho; Jen-Kun Lin
Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.
Carcinogenesis 2004;25(7):1109-18.
2004: Yu-Ping Lin; Ben-Zhan Zhu; Ming-Chen Yang; Balz Frei; Ming-Hsiung Pan; Jen-Kun Lin; Ying-Jan Wang
Bcl-2 overexpression inhibits tetrachlorohydroquinone-induced apoptosis in NIH3T3 cells: a possible mechanism for tumor promotion.
Molecular carcinogenesis 2004;40(1):24-33.
2004: Wei-Jen Chen; Jen-Kun Lin
Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip1/WAF1, and Bax proteins.
The Journal of biological chemistry 2004;279(14):13496-505.
2004: Tzong-Der Way; Ming-Ching Kao; Jen-Kun Lin
Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway.
The Journal of biological chemistry 2004;279(6):4479-89.
2004: Wei-Jen Chen; Jen-Kun Lin
Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades.
Journal of agricultural and food chemistry 2004;52(1):55-64.
2004: Chiung-Nien Chen; Chia-Li Wu; Jen-Kun Lin
Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cells.
Biochemical pharmacology 2004;67(1):53-66.
2003: Chiung-Nien Chen; Chia-Min Liang; Jueng-Rong Lai; Yao-Jen Tsai; Jyh-Shyan Tsay; Jen-Kun Lin
Capillary electrophoretic determination of theanine, caffeine, and catechins in fresh tea leaves and oolong tea and their effects on rat neurosphere adhesion and migration.
Journal of agricultural and food chemistry 2003;51(25):7495-503.
2003: Wen-Sen Lee; Rong-Jane Chen; Ying-Jan Wang; How Tseng; Jiiang-Huei Jeng; Shyr-Yi Lin; Yu-Chih Liang; Chien-Ho Chen; Chien-Huang Lin; Jen-Kun Lin; Pei-Yin Ho; Jan-Show Chu; Wei-Lu Ho; Li-Ching Chen; Yuan-Soon Ho
In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest.
International journal of cancer. Journal international du cancer 2003;106(1):125-37.
2003: Min-Hsiung Pan; Mei-Chen Huang; Ying-Jan Wang; Jen-Kun Lin; Chao-Hsien Lin
Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells.
Journal of agricultural and food chemistry 2003;51(14):3977-84.
2003: Wei-Jen Chen; Chun-Yun Chang; Jen-Kun Lin
Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip).
Biochemical pharmacology 2003;65(11):1777-85.
2003: Jean-Dean Liu; Ying-Jan Wang; Chien-Ho Chen; Cheng-Fei Yu; Li-Ching Chen; Jen-Kun Lin; Yu-Chih Liang; Shyr-Yi Lin; Yuan-Soon Ho
Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells.
Molecular carcinogenesis 2003;37(1):39-50.
2003: Jean-Dean Liu; Shyr-Yi Lin; Yuan-Soon Ho; Shiann Pan; Ling-Fang Hung; Shu-Huei Tsai; Jen-Kun Lin; Yu-Chih Liang
Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells.
Molecular carcinogenesis 2003;37(1):16-24.
2003: Chiung-Nien Chen; Chia-Li Wu; Horng-Shing Shy; Jen-Kun Lin
Cytotoxic prenylflavanones from Taiwanese propolis.
Journal of natural products 2003;66(4):503-6.
2003: Yu-Chih Liang; Shu-Huei Tsai; Linda Chen; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells.
Biochemical pharmacology 2003;65(7):1053-60.
2003: Yung-Sheng Lin; Yao-Jen Tsai; Jyh-Shyan Tsay; Jen-Kun Lin
Factors affecting the levels of tea polyphenols and caffeine in tea leaves.
Journal of agricultural and food chemistry 2003;51(7):1864-73.
2003: Yung-Sheng Lin; Sang-Shung Wu; Jen-Kun Lin
Determination of tea polyphenols and caffeine in tea flowers (Camellia sinensis) and their hydroxyl radical scavenging and nitric oxide suppressing effects.
Journal of agricultural and food chemistry 2003;51(4):975-80.
2003: C-W Yeh; W-J Chen; Chun-Te Chiang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects.
The pharmacogenomics journal 2003;3(5):267-76.
2002: Li-Lun Ho; Wei-Jen Chen; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1.
European journal of pharmacology 2002;453(2-3):149-58.
2002: Jen-Kun Lin
Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways.
Archives of pharmacal research 2002;25(5):561-71.
2002: Min-Hsiung Pan; Wei-Jen Chen; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin
Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells.
Carcinogenesis 2002;23(10):1677-84.
2002: Yuan-Soon Ho; Hung-Bin Liou; Jen-Kun Lin; Jiiang-Huei Jeng; Min-Hsiung Pan; Yu-Ping Lin; How-Ran Guo; Sheng-Yow Ho; Ching-Chang Lee; Ying-Jan Wang
Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide.
Archives of toxicology 2002;76(8):484-93.
2002: Chia-Jen Tseng; Ying-Jan Wang; Yu-Chih Liang; Jiiang-Huei Jeng; Wen-Sen Lee; Jen-Kun Lin; Chien-Ho Chen; I-Chun Liu; Yuan-Soon Ho
Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells.
Toxicology 2002;175(1-3):123-42.
2002: Ai-Hsiang Lo; Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages.
Carcinogenesis 2002;23(6):983-91.
2002: Chun-Mao Lin; Chien-Shu Chen; Chien-Tsu Chen; Yu-Chih Liang; Jen-Kun Lin
Molecular modeling of flavonoids that inhibits xanthine oxidase.
Biochemical and biophysical research communications 2002;294(1):167-72.
2002: Chun-Mao Lin; Chien-Tsu Chen; Hsiao-Hui Lee; Jen-Kun Lin
Prevention of cellular ROS damage by isovitexin and related flavonoids.
Planta medica 2002;68(4):365-7.
2002: Chih-Hsiung Wu; Jiiang-Huei Jeng; Ying-Jan Wang; Chia-Jen Tseng; Yu-Chih Liang; Chien-Ho Chen; Horng-Mo Lee; Jen-Kun Lin; Chien-Huang Lin; Shyr-Yi Lin; Chung-Pei Li; Yuan-Soon Ho
Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest.
Toxicology and applied pharmacology 2002;180(1):22-35.
2002: Chih-Hung Hsu; Shuang-En Chuang; Manfred Hergenhahn; Min-Liang Kuo; Jen-Kun Lin; Chang-Yao Hsieh; Ann-Lii Cheng
Pre-clinical and early-phase clinical studies of curcumin as chemopreventive agent for endemic cancers in Taiwan.
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29 Suppl 1():194-200.
2002: Yu-Chih Liang; De-Cheng Tsai; Shoei-Yn Lin-Shiau; Chieh-Fu Chen; Chi-Tang Ho; Jen-Kun Lin
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3,3'-digallate in mouse.
Nutrition and cancer 2002;42(2):217-23.
2002: Ying-Jan Wang; Cheng-Fei Yu; Li-Ching Chen; Chien-Ho Chen; Jen-Kun Lin; Yu-Chih Liang; Chien-Huang Lin; Shyr-Yi Lin; Chin-Fa Chen; Yuan-Soon Ho
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.
Journal of cellular biochemistry 2002;87(2):147-59.
2002: Shu-Huei Tsai; Yu-Chih Liang; Linda Chen; Feng-Ming Ho; Ming-Shium Hsieh; Jen-Kun Lin
Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells.
Journal of cellular biochemistry 2002;84(4):750-8.
2001: Shu-Huei Tsai; Ming-Shium Hsieh; Linda Chen; Yu-Chih Liang; Jen-Kun Lin; Shyr-Yi Lin
Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species.
Toxicology letters 2001;123(1):11-9.
2001: Ann-Lii Cheng; Chih-Hung Hsu; Jen-Kun Lin; Mow-Ming Hsu; Yunn-Fang Ho; T S Shen; J Y Ko; Jaw-Town Lin; Bor-Ru Lin; W Ming-Shiang; Hsin-Su Yu; Shiou-Hwa Jee; G S Chen; T M Chen; Chi-An Chen; Ming-Kuen Lai; Yeong-Shiau Pu; MH Pan; Ying-Jan Wang; C C Tsai; Chang-Yao Hsieh
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Anticancer research 2001;21(4B):2895-900.
2001: Y C Liang; S H Tsai; D C Tsai; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages.
FEBS letters 2001;496(1):12-8.
2001: Jen-Kun Lin; Shoei-Yn Lin-Shiau
Mechanisms of cancer chemoprevention by curcumin.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 2001;25(2):59-66.
2001: S H Chen; Shing-Hwa Liu; Y C Liang; Jen-Kun Lin; Shoei-Yn Lin-Shiau
Oxidative stress and c-Jun-amino-terminal kinase activation involved in apoptosis of primary astrocytes induced by disulfiram-Cu(2+) complex.
European journal of pharmacology 2001;414(2-3):177-88.
2001: Yen-Chou Chen; Shu-Huei Tsai; Shing-Chuan Shen; Jen-Kun Lin; W R Lee
Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
European journal of cell biology 2001;80(3):213-21.
2001: MH Pan; W L Chang; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin
Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells.
Journal of agricultural and food chemistry 2001;49(3):1464-74.
2000: MH Pan; Yu-Chih Liang; Shoei-Yn Lin-Shiau; N Q Zhu; Chi-Tang Ho; Jen-Kun Lin
Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells.
Journal of agricultural and food chemistry 2000;48(12):6337-46.
2000: Rong-Jane Chen; Wen-Sen Lee; Yu-Chih Liang; Jen-Kun Lin; Ying-Jan Wang; Chien-Huang Lin; J Y Hsieh; C C Chaing; Yuan-Soon Ho
Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines.
Toxicology and applied pharmacology 2000;169(2):132-41.
2000: MH Pan; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages.
Biochemical pharmacology 2000;60(11):1665-76.
2000: IK Wang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation.
Oncology 2000;59(3):245-54.
2000: S H Chen; Shing-Hwa Liu; Y C Liang; Jen-Kun Lin; Shoei-Yn Lin-Shiau
Death signaling pathway induced by pyrrolidine dithiocarbamate-Cu(2+) complex in the cultured rat cortical astrocytes.
Glia 2000;31(3):249-61.
2000: CF Chan; Wei-Zen Sun; Jen-Kun Lin; Shoei-Yn Lin-Shiau
Activation of transcription factors of nuclear factor kappa B, activator protein-1 and octamer factors in hyperalgesia.
European journal of pharmacology 2000;402(1-2):61-8.
2000: IK Wang; Shoei-Yn Lin-Shiau; Po-Chung Chen; Jen-Kun Lin
Hypotriglyceridemic effect of Anka (a fermented rice product of monascus sp.) in rats.
Journal of agricultural and food chemistry 2000;48(8):3183-9.
2000: Jen-Kun Lin; K J Chen; GY Liu; Y R Chu; S Y Lin-Shiau
Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate.
Chemico-biological interactions 2000;127(3):219-36.
2000: Jen-Kun Lin; Po-Chung Chen; Chi-Tang Ho; Shoei-Yn Lin-Shiau
Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate.
Journal of agricultural and food chemistry 2000;48(7):2736-43.
2000: MH Pan; Shoei-Yn Lin-Shiau; Chi-Tang Ho; J H Lin; Jen-Kun Lin
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages.
Biochemical pharmacology 2000;59(4):357-67.
2000: IK Wang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Induction of apoptosis by lovastatin through activation of caspase-3 and DNase II in leukaemia HL-60 cells.
Pharmacology & toxicology 2000;86(2):83-91.
2000: Tzyh-Chyuan Hour; L Chen; Jen-Kun Lin
Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells: implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2.
European journal of cell biology 2000;79(2):121-9.
2000: Jen-Kun Lin; MH Pan; Shoei-Yn Lin-Shiau
Recent studies on the biofunctions and biotransformations of curcumin.
BioFactors (Oxford, England) 2000;13(1-4):153-8.
2000: Jen-Kun Lin; Yu-Chih Liang
Cancer chemoprevention by tea polyphenols.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 2000;24(1):1-13.
1999: Tzyh-Chyuan Hour; S Y Shiau; Jen-Kun Lin
Suppression of N-methyl-N'-nitro-N-nitrosoguanidine- and S-nitrosoglutathione-induced apoptosis by Bcl-2 through inhibiting glutathione-S-transferase pi in NIH3T3 cells.
Toxicology letters 1999;110(3):191-202.
1999: Yi-Jane Chen; Jen-Kun Lin; Shoei-Yn Lin-Shiau
Proliferation arrest and induction of CDK inhibitors p21 and p27 by depleting the calcium store in cultured C6 glioma cells.
European journal of cell biology 1999;78(11):824-31.
1999: Yuan-Soon Ho; H L Liu; J S Duh; R J Chen; W L Ho; Jiiang-Huei Jeng; Ying-Jan Wang; Jen-Kun Lin
Induction of apoptosis by S-nitrosoglutathione and Cu2+ or Ni2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells.
Molecular carcinogenesis 1999;26(3):201-11.
1999: IK Wang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells.
European journal of cancer (Oxford, England : 1990) 1999;35(10):1517-25.
1999: Yu-Chih Liang; Yao-Ting Huang; S H Tsai; Shoei-Yn Lin-Shiau; C F Chen; Jen-Kun Lin
Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.
Carcinogenesis 1999;20(10):1945-52.
1999: Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chieh-Fu Chen; Jen-Kun Lin
Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate.
Journal of cellular biochemistry 1999;75(1):1-12.
1999: MH Pan; J H Lin; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Induction of apoptosis by penta-O-galloyl-beta-D-glucose through activation of caspase-3 in human leukemia HL-60 cells.
European journal of pharmacology 1999;381(2-3):171-83.
1999: Jen-Kun Lin; Yu-Chih Liang; Shoei-Yn Lin-Shiau
Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade.
Biochemical pharmacology 1999;58(6):911-5.
1999: S H Tsai; Yu-Chih Liang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.
Journal of cellular biochemistry 1999;74(4):606-15.
1999: Jen-Kun Lin; Shu-Huei Tsai
Chemoprevention of cancer and cardiovascular disease by resveratrol.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1999;23(3):99-106.
1999: Y C Chen; S H Tsai; S Y Lin-Shiau; Jen-Kun Lin
Elevation of apoptotic potential by anoxia hyperoxia shift in NIH3T3 cells.
Molecular and cellular biochemistry 1999;197(1-2):147-59.
1999: GY Liu; K J Chen; S Y Lin-Shiau; Jen-Kun Lin
Peroxyacetyl nitrate-induced apoptosis through generation of reactive oxygen species in HL-60 cells.
Molecular carcinogenesis 1999;25(3):196-206.
1999: Bing-Sheng Wang; Jen-Kun Lin; Shoei-Yn Lin-Shiau
Role of tyrosine kinase activity in 2,2',2''-tripyridine-induced nitricoxide generation in macrophages.
Biochemical pharmacology 1999;57(12):1367-73.
1999: Tzyh-Chyuan Hour; Yu-Chih Liang; I S Chu; Jen-Kun Lin
Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(6):569-79.
1999: Y C Chen; Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin
Inhibition of TPA-induced protein kinase C and transcription activator protein-1 binding activities by theaflavin-3,3'-digallate from black tea in NIH3T3 cells.
Journal of agricultural and food chemistry 1999;47(4):1416-21.
1999: Yu-Chih Liang; Y C Chen; Yun-Lian Lin; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin
Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate.
Carcinogenesis 1999;20(4):733-6.
1999: MH Pan; T M Huang; Jen-Kun Lin
Biotransformation of curcumin through reduction and glucuronidation in mice.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):486-94.
1999: Yun-Lian Lin; S H Tsai; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin
Theaflavin-3,3'-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-kappaB in macrophages.
European journal of pharmacology 1999;367(2-3):379-88.
1999: Shu-Huei Tsai; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol.
British journal of pharmacology 1999;126(3):673-80.
1999: Yuan-Soon Ho; H M Lee; C R Chang; Jen-Kun Lin
Induction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines.
Biochemical pharmacology 1999;57(2):143-54.
1998: W J Chi; Shin-Lian Doong; Shoei-Yn Lin-Shiau; C W Boone; G J Kelloff; Jen-Kun Lin
Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.
Carcinogenesis 1998;19(12):2133-8.
1998: Yuan-Soon Ho; P W Tsai; C F Yu; H L Liu; R J Chen; Jen-Kun Lin
Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines.
Toxicology and applied pharmacology 1998;153(1):39-47.
1998: Y C Chen; S Y Lin-Shiau; Jen-Kun Lin
Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis.
Journal of cellular physiology 1998;177(2):324-33.
1998: Ying-Jan Wang; M H Pan; Yuan-Soon Ho; Jen-Kun Lin
Mechanisms of cell death induced by nitric oxide and peroxynitrite in Calu-1 cells.
Environmental toxicology and pharmacology 1998;6(1):35-44.
1998: GY Liu; N Frank; H Bartsch; Jen-Kun Lin
Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFkappaB, c-fos/c-jun, and p53 proteins.
Molecular carcinogenesis 1998;22(4):235-46.
1998: Liang-In Lin; Y F Ke; Y C Ko; Jen-Kun Lin
Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion.
Oncology 1998;55(4):349-53.
1998: C C Lee; J Y Liu; Jen-Kun Lin; Jan-Show Chu; Jin-Yuh Shew
p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions.
Cancer letters 1998;125(1-2):1-7.
1998: Tzyh-Chyuan Hour; L Chen; Jen-Kun Lin
Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests.
Mutagenesis 1998;13(2):157-66.
1998: Liang-In Lin; Po-Huang Lee; C M Wu; Jen-Kun Lin
Significance of nm23 mRNA expression in human hepatocellular carcinoma.
Anticancer research 1998;18(1B):541-6.
1997: Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chieh-Fu Chen; Jen-Kun Lin
Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells.
Journal of cellular biochemistry 1997;67(1):55-65.
1997: Yun-Lian Lin; Jen-Kun Lin
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.
Molecular pharmacology 1997;52(3):465-72.
1997: Ying-Jan Wang; MH Pan; Ann-Lii Cheng; Liang-In Lin; Y S Ho; Chang-Yao Hsieh; Jen-Kun Lin
Stability of curcumin in buffer solutions and characterization of its degradation products.
Journal of pharmaceutical and biomedical analysis 1997;15(12):1867-76.
1997: Ying-Jan Wang; Yuan-Soon Ho; Shi-Wei Chu; H J Lien; T H Liu; Jen-Kun Lin
Induction of glutathione depletion, p53 protein accumulation and cellular transformation by tetrachlorohydroquinone, a toxic metabolite of pentachlorophenol.
Chemico-biological interactions 1997;105(1):1-16.
1997: Yuan-Soon Ho; H M Lee; T C Mou; Ying-Jan Wang; Jen-Kun Lin
Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels.
Molecular carcinogenesis 1997;19(2):101-13.
1997: Liang-In Lin; C H Liu; Yee-Chun Chen; Ming-Ching Shen; Chiu-Hwa Wang; Y L Huang; Jen-Kun Lin
PIG-A gene mutations in four Taiwanese patients with paroxysmal nocturnal haemoglobinuria following aplastic anaemia.
British journal of haematology 1997;97(2):286-92.
1997: Jen-Kun Lin; Y C Chen; Yao-Ting Huang; Shoei-Yn Lin-Shiau
Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin.
Journal of cellular biochemistry. Supplement 1997;28-29():39-48.
1997: S F Lee; Jen-Kun Lin
Inhibitory effects of phytopolyphenols on TPA-induced transformation, PKC activation, and c-jun expression in mouse fibroblast cells.
Nutrition and cancer 1997;28(2):177-83.
1997: Song-Nan Chow; Jen-Kun Lin; S S Li; C H Chien
Identification of LDH-ras p21 protein complex and expression of these genes in human ovarian cancer.
Gynecologic oncology 1997;64(1):114-20.
1996: Y C Chen; T C Kuo; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells.
Molecular carcinogenesis 1996;17(4):224-34.
1996: Min-Liang Kuo; T S Huang; Jen-Kun Lin
Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells.
Biochimica et biophysica acta 1996;1317(2):95-100.
1996: Y C Chen; Jen-Kun Lin
Photodynamic anticancer agent merocyanine540 inhibits cell growth by apoptosis.
Anticancer research 1996;16(5A):2781-8.
1996: King-Jen Chang; Jen-Kun Lin; P H Lee; Y S Hsieh; C K Cheng; J Y Liu
The altered activity of membrane-bound protein kinase C in human liver cancer.
Cancer letters 1996;105(2):211-5.
1996: M C Jiang; Hsin-Fang Yang-Yen; Jen-Kun Lin; Jeffrey Jong-Young Yen
Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells.
Oncogene 1996;13(3):609-16.
1996: Y S Ho; Y J Wang; Jen-Kun Lin
Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells.
Molecular carcinogenesis 1996;16(1):20-31.
1996: Min-Liang Kuo; T C Meng; Jen-Kun Lin
Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells.
Carcinogenesis 1996;17(4):815-20.
1996: S F Lee; Yao-Ting Huang; W S Wu; Jen-Kun Lin
Induction of c-jun protooncogene expression by hydrogen peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation.
Free radical biology & medicine 1996;21(4):437-48.
1996: M C Jiang; Hsin-Fang Yang-Yen; Jeffrey Jong-Young Yen; Jen-Kun Lin
Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.
Nutrition and cancer 1996;26(1):111-20.
1996: Yao-Ting Huang; M L Kuo; J Y Liu; S Y Huang; Jen-Kun Lin
Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin.
European journal of cancer (Oxford, England : 1990) 1996;32A(1):146-51.
1995: S F Lee; Yu-Chih Liang; Jen-Kun Lin
Inhibition of 1,2,4-benzenetriol-generated active oxygen species and induction of phase II enzymes by green tea polyphenols.
Chemico-biological interactions 1995;98(3):283-301.
1995: Min-Liang Kuo; T S Huang; Jen-Kun Lin
Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human colon cancer cells.
Biochemical pharmacology 1995;50(8):1217-22.
1995: Tzyh-Chyuan Hour; C C Lee; Jen-Kun Lin
A new mutagenicity assay method for frameshift mutagens based on deleting or inserting a guanosine nucleotide in the beta-lactamase gene.
Mutagenesis 1995;10(5):433-8.
1995: Y S Ho; Jen-Kun Lin
Preferential promutagenic lesions at exons 7-8 of human p53 genomic DNA induced by the direct-acting hepatocarcinogens N-nitroso-2-acetylaminofluorene and N-acetoxy-2-acetylaminofluorene.
Cancer letters 1995;95(1-2):39-47.
1995: Y S Ho; H T Cheng; Y J Wang; Jen-Kun Lin
p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats.
Molecular carcinogenesis 1995;13(3):182-90.
1995: Y J Wang; Y S Ho; M J Lo; Jen-Kun Lin
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Chemico-biological interactions 1995;94(2):135-45.
1995: J M Chang; W C CHen; D Hong; Jen-Kun Lin
The inhibition of DMBA-induced carcinogenesis by neoxanthin in hamster buccal pouch.
Nutrition and cancer 1995;24(3):325-33.
1994: Min-Liang Kuo; Jen-Kun Lin; T S Huang; N C Yang
Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine.
Cancer letters 1994;87(1):91-7.
1994: C C Lee; H K Lin; Jen-Kun Lin
A reverse mutagenicity assay for alkylating agents based on a point mutation in the beta-lactamase gene at the active site serine codon.
Mutagenesis 1994;9(5):401-5.
1994: Jen-Kun Lin; C A Shih
Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells.
Carcinogenesis 1994;15(8):1717-21.
1994: Y S Ho; Jen-Kun Lin
N-nitroso-2-acetylaminofluorene: a direct-acting carcinogen inducing hepatocellular carcinoma in Sprague-Dawley rats.
Japanese journal of cancer research : Gann 1994;85(8):794-800.
1993: Min-Liang Kuo; W S Wu; K C Lee; Jen-Kun Lin
Effects of tannic acid on 12-O-tetradecanoylphorbol-13-acetate-induced protein kinase C activation in NIH 3T3 cells.
Biochemical pharmacology 1993;46(8):1327-32.
1993: Min-Liang Kuo; Jen-Kun Lin
The genotoxicity of the waste water discharged from paraquat manufacturing and its pyridyl components.
Mutation research 1993;300(3-4):223-9.
1993: J Y Liu; S J Lin; Jen-Kun Lin
Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells.
Carcinogenesis 1993;14(5):857-61.
1993: C A Shih; Jen-Kun Lin
Inhibition of 8-hydroxydeoxyguanosine formation by curcumin in mouse fibroblast cells.
Carcinogenesis 1993;14(4):709-12.
1993: J M Wang; Shoei-Yn Lin-Shiau; Jen-Kun Lin
Relaxation of rat thoracic aorta by N-nitroso compounds and nitroprusside and their modifications of nucleic acid bases through release of nitric oxide.
Biochemical pharmacology 1993;45(4):819-25.
1992: Min-Liang Kuo; K C Lee; Jen-Kun Lin
Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems.
Mutation research 1992;270(2):87-95.
1992: Jen-Kun Lin; S F Lee
Enhancement of the mutagenicity of polyphenols by chlorination and nitrosation in Salmonella typhimurium.
Mutation research 1992;269(2):217-24.
1992: Jen-Kun Lin; Y S Ho
Hepatotoxicity and hepatocarcinogenicity in rats fed squid with or without exogenous nitrite.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(8):695-702.
1992: Jen-Kun Lin; J T Cheng; S Y Lin-Shiau
Enhancement of the mutagenicity of IQ and MeIQ by nitrite in the Salmonella system.
Mutation research 1992;278(4):277-87.
1992: J M Wang; Tzuu-Huei Ueng; Jen-Kun Lin
Biochemical and morphological alterations in the lungs and livers of mice following exposure to polluted air in a traffic tunnel.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1992;16(2):77-83.
1992: Jen-Kun Lin; S F Tseng
Chromosomal aberrations and sister-chromatid exchanges induced by N-nitroso-2-acetylaminofluorene and their modifications by arsenite and selenite in Chinese hamster ovary cells.
Mutation research 1992;265(2):203-10.
1991: T S Huang; S C Lee; Jen-Kun Lin
Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5292-6.
1991: C J Wang; H S Shiah; Jen-Kun Lin
Modulatory effect of crocetin on aflatoxin B1 cytotoxicity and DNA adduct formation in C3H10T1/2 fibroblast cell.
Cancer letters 1991;56(1):1-10.
1990: C J Wang; S W Wang; H S Shiah; Jen-Kun Lin
Effect of ethanol on hepatotoxicity and hepatic DNA-binding of aflatoxin B1 in rats.
Biochemical pharmacology 1990;40(4):715-21.
1990: S Y Li; Jen-Kun Lin
Differential bleomycin susceptibility in cultured lymphocytes of fragile X patients and normal individuals.
Human genetics 1990;85(3):267-71.
1990: Jen-Kun Lin; M L Kuo
Induction of ouabain-resistance mutation and cycle-dependent transformation of C3H/10T1/2 cells by N-nitroso-2-acetylaminofluorene.
Mutation research 1990;230(1):35-43.
1989: C J Wang; M Y Chou; Jen-Kun Lin
Inhibition of growth and development of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids.
Cancer letters 1989;48(2):135-42.
1989: Jen-Kun Lin; D C Hurng
Potentiation of ferrous sulphate and ascorbate on the microbial transformation of endogenous trimethylamine N-oxide to trimethylamine and dimethylamine in squid extracts.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(9):613-8.
1989: C J Wang; Jen-Kun Lin
Inhibitory effects of carotenoids and retinoids on the in vitro growth of rat C-6 glioma cells.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1989;13(3):176-83.
1989: M L Kuo; Jen-Kun Lin
The relationship between DNA damage and mutation frequency in mammalian cell lines treated with N-nitroso-N-2-fluorenylacetamide.
Mutation research 1989;212(2):231-9.
1989: Jen-Kun Lin; I H Huang; K W Lee; Shoei-Yn Lin-Shiau
Mutagenicity of dipyridyls and their methylated derivatives in Salmonella typhimurium/rat liver microsome system.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1989;13(1):56-63.
1988: Jen-Kun Lin; M L Kuo
N-nitroso-N-2-fluorenylacetamide: a new direct-acting mutagen and teratogen.
Mutation research 1988;201(1):117-26.