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Lih-Ling Lin

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Anatomy

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Publications

TOP 3
Marcus Ronninger; Maria Seddighzadeh; Klementy Shchetynsky; Padmalatha S Reddy; James D Clark; Yongjing Guo; Andrew Hill; Mohsen Khademi; Lih-Ling Lin; Tomas Olsson; Margot O'Toole; Leonid Padyukov
The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.
Yike Ni; Jean-Baptiste Telliez; Julie Liu; Michael Luong; Derek Cole; Rajiah Denny; Ariamala Gopalsamy; J Perry Hall; Yonghan Hu; Manus Ipek; Julie Lee; Lih-Ling Lin
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.
Yonghan Hu; Manus Ipek; Lih-Ling Lin; Julie Liu; Michael Luong; Yike Ni; Jean-Baptiste Telliez; Suvit Thaisrivongs; Xiaolun Wang; David R Anderson; Timothy Chamberlain; Derek Cole; Rajiah Aldrin Denny; J Perry Hall; Ariamala Gopalsamy
Discovery of indazoles as inhibitors of Tpl2 kinase.

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All Publications

2012: Marcus Ronninger; Maria Seddighzadeh; Klementy Shchetynsky; Padmalatha S Reddy; James D Clark; Yongjing Guo; Andrew Hill; Mohsen Khademi; Lih-Ling Lin; Tomas Olsson; Margot O'Toole; Leonid Padyukov
The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.
Genome medicine 2012;4(1):2.
2011: Yike Ni; Jean-Baptiste Telliez; Julie Liu; Michael Luong; Derek Cole; Rajiah Denny; Ariamala Gopalsamy; J Perry Hall; Yonghan Hu; Manus Ipek; Julie Lee; Lih-Ling Lin
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(19):5952-6.
2011: Yonghan Hu; Manus Ipek; Lih-Ling Lin; Julie Liu; Michael Luong; Yike Ni; Jean-Baptiste Telliez; Suvit Thaisrivongs; Xiaolun Wang; David R Anderson; Timothy Chamberlain; Derek Cole; Rajiah Aldrin Denny; J Perry Hall; Ariamala Gopalsamy
Discovery of indazoles as inhibitors of Tpl2 kinase.
Bioorganic & medicinal chemistry letters 2011;21(16):4758-61.
2010: Erica Marchlik; Paresh Thakker; Thaddeus Carlson; Zhaozhao Jiang; Mark Ryan; Suzana Marusic; Nadege Goutagny; Wen Kuang; G Roger Askew; Victoria Roberts; Stephen Benoit; Tianhui Zhou; Vincent Ling; Richard Pfeifer; Nancy Stedman; Katherine A Fitzgerald; Lih-Ling Lin; J Perry Hall
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality.
Journal of leukocyte biology 2010;88(6):1171-80.
2010: Benfang Helen Ruan; Xin Li; Aaron R Winkler; Kristina M Cunningham; Jun Kuai; Rita M Greco; Karl H Nocka; Lori Fitz; Jill F Wright; Debra D Pittman; Xiang-Yang Tan; Janet E Paulsen; Lih-Ling Lin; David G Winkler
Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4213-22.
2009: Jun Kuai; Bernard Gregory; Andrew Hill; Debra D Pittman; Jeffrey L Feldman; Tom Brown; Brenda Carito; Margot O'Toole; Renee Ramsey; Oskar Adolfsson; Kathleen M Shields; Ken Dower; J Perry Hall; Yahya Kurdi; Jonathan T Beech; Jagdeep Nanchahal; Marc Feldmann; Brian M Foxwell; Fionula M Brennan; David G Winkler; Lih-Ling Lin
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Rheumatology (Oxford, England) 2009;48(11):1352-8.
2009: Lin Liu; Padma L Channavajhala; Vikram R Rao; Ioannis Moutsatsos; Leeying Wu; Yuhua Zhang; Lih-Ling Lin; Yongchang Qiu
Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway.
Biochimica et biophysica acta 2009;1794(10):1485-95.
2009: Susan Carpenter; Thaddeus Carlson; Jérôme Dellacasagrande; Amaya Garcia; Sharon Gibbons; Paul Hertzog; Anthony Lyons; Lih-Ling Lin; Marina Lynch; Tom Monie; Caroline Murphy; Katherine J Seidl; Christine Wells; Aisling Dunne; Luke A J O'Neill
TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3989-95.
2009: Junjun Wu; Neal Green; Rajeev Hotchandani; Yonghan Hu; Jeffrey Condon; Adrian Huang; Neelu Kaila; Huan-Qiu Li; Satenig Guler; Wei Li; Steve Y Tam; Qin Wang; Jeffrey W Pelker; Suzana Marusic; Sang Hsu; J Perry Hall; Jean-Baptiste Telliez; Junqing Cui; Lih-Ling Lin
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Bioorganic & medicinal chemistry letters 2009;19(13):3485-8.
2008: Ken Dower; Debra K Ellis; Kathryn Saraf; Scott Jelinsky; Lih-Ling Lin
Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3520-34.
2008: Mary Collins; David G Winkler; Lih-Ling Lin
Complex responses to a diverse environment.
Genome biology 2008;9(6):311.
2007: Desirée H H Tsao; Wah-Tung Hum; Sang Hsu; Karl Malakian; Lih-Ling Lin
The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway.
Journal of biomolecular NMR 2007;39(4):337-42.
2007: J Perry Hall; Yahya Kurdi; Sang Hsu; John W Cuozzo; Julie Liu; Jean-Baptiste Telliez; Katherine J Seidl; Aaron Winkler; Yonghan Hu; Neal Green; G Roger Askew; Steve Tam; James D Clark; Lih-Ling Lin
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
The Journal of biological chemistry 2007;282(46):33295-304.
2007: Neelu Kaila; Neal Green; Huan-Qiu Li; Yonghan Hu; Kristin Janz; Lori Krim Gavrin; Jennifer Thomason; Steve Tam; Dennis Powell; John W Cuozzo; J Perry Hall; Jean-Baptiste Telliez; Sang Hsu; Cheryl Nickerson-Nutter; Qin Wang; Lih-Ling Lin
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Bioorganic & medicinal chemistry 2007;15(19):6425-42.
2007: Neal Green; Yonghan Hu; Kristin Janz; Huan-Qiu Li; Neelu Kaila; Satenig Guler; Jennifer Thomason; Diane Joseph-McCarthy; Steve Y Tam; Rajeev Hotchandani; Junjun Wu; Adrian Huang; Qin Wang; Louis Leung; Jeffrey W Pelker; Suzana Marusic; Sang Hsu; Jean-Baptiste Telliez; J Perry Hall; John W Cuozzo; Lih-Ling Lin
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
Journal of medicinal chemistry 2007;50(19):4728-45.
2007: Qin Wang; Yuhua Zhang; J Perry Hall; Lih-Ling Lin; Uma Raut; Nevena Mollova; Neal Green; John W Cuozzo; Shannon Chesley; Xin Xu; Jeremy I Levin; Vikram S Patel
A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production.
Journal of pharmacological and toxicological methods 2007;56(1):67-71.
2007: Natalia Ronkina; Alexey Kotlyarov; Oliver Dittrich-Breiholz; Michael Kracht; Edward Hitti; K Milarski; R Askew; S Marusic; Lih-Ling Lin; Matthias Gaestel; Jean-Baptiste Telliez
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
Molecular and cellular biology 2007;27(1):170-81.
2006: Yonghan Hu; Neal Green; Lori Krim Gavrin; Kristin Janz; Neelu Kaila; Huan-Qiu Li; Jennifer R Thomason; John W Cuozzo; J Perry Hall; Sang Hsu; Cheryl Nickerson-Nutter; Jean-Baptiste Telliez; Lih-Ling Lin; Steve Tam
Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.
Bioorganic & medicinal chemistry letters 2006;16(23):6067-72.
2006: Martin Hegen; Matthias Gaestel; Cheryl Nickerson-Nutter; Lih-Ling Lin; Jean-Baptiste Telliez
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1913-7.
2005: Lori Krim Gavrin; Neal Green; Yonghan Hu; Kristin Janz; Neelu Kaila; Huan-Qiu Li; Steve Y Tam; Jennifer R Thomason; Ariamala Gopalsamy; Gregory Ciszewski; John W Cuozzo; J Perry Hall; Sang Hsu; Jean-Baptiste Telliez; Lih-Ling Lin
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2005;15(23):5288-92.
2005: Padma L Channavajhala; Vikram R Rao; Vikki Spaulding; Lih-Ling Lin; Y George Zhang
hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation.
Biochemical and biophysical research communications 2005;334(4):1214-8.
2004: Yuhua Zhang; Martin Hegen; Jun Xu; James Carl Keith; Guixian Jin; Xuemei Du; Terri Cummons; Barbara J Sheppard; LinHong Sun; Yi Zhu; Vikram R Rao; Qin Wang; Weixin Xu; Rebecca Cowling; Cheryl Nickerson-Nutter; Jay Gibbons; Jerauld S Skotnicki; Lih-Ling Lin; Jeremy Levin
Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme.
International immunopharmacology 2004;4(14):1845-57.
2004: Jun Kuai; Joe Wooters; J Perry Hall; Vikram R Rao; Elliott Nickbarg; Bilian Li; Moitreyee Chatterjee-Kishore; Yongchang Qiu; Lih-Ling Lin
NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.
The Journal of biological chemistry 2004;279(51):53266-71.
2004: Brenda S Luciano; Sang Hsu; Padma L Channavajhala; Lih-Ling Lin; John W Cuozzo
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
The Journal of biological chemistry 2004;279(50):52117-23.
2004: Yvonne M Yannoni; Matthias Gaestel; Lih-Ling Lin
P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.
FEBS letters 2004;564(1-2):205-11.
2004: Desirée H H Tsao; Wah-Tung Hum; Sang Hsu; Michelle McGuire; Karl Malakian; Lih-Ling Lin
Assignment of 1H, 13C and 15N resonances of the death domain of TRADD.
Journal of biomolecular NMR 2004;28(4):407-8.
2004: Yuhua Zhang; Jun Xu; Jeremy Levin; Martin Hegen; Guangde Li; Heidi Robertshaw; Fionula Brennan; Terri Cummons; Dave Clarke; Nichole Vansell; Cheryl Nickerson-Nutter; Dauphine Barone; Ken Mohler; Roy Black; Jerauld S Skotnicki; Jay Gibbons; Eugene Eyo Akujuru; Philip Frost; Glenn Larsen; Lih-Ling Lin
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2004;309(1):348-55.
2003: Padma L Channavajhala; Leeying Wu; John W Cuozzo; J Perry Hall; Wei Liu; Lih-Ling Lin; Yuhua Zhang
Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling.
The Journal of biological chemistry 2003;278(47):47089-97.
2003: Kathryn W Underwood; Kevin D Parris; Elizabeth Federico; Lidia Mosyak; Robert Czerwinski; Tania Shane; Meggin Taylor; Kristine Svenson; Yan Liu; Chu-Lai Hsiao; Scott Wolfrom; Michelle Maguire; Karl Malakian; Jean-Baptiste Telliez; Lih-Ling Lin; Ron Kriz; Jasbir Seehra; William S Somers; Mark L Stahl
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.
Structure (London, England : 1993) 2003;11(6):627-36.
2003: Jun Kuai; Elliott Nickbarg; Joe Wooters; Yongchang Qiu; Jack Wang; Lih-Ling Lin
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis.
The Journal of biological chemistry 2003;278(16):14363-9.
2002: Alexey Kotlyarov; Yvonne Yannoni; Susann Fritz; Kathrin Laass; Jean-Baptiste Telliez; Deborah Pitman; Lih-Ling Lin; Matthias Gaestel
Distinct cellular functions of MK2.
Molecular and cellular biology 2002;22(13):4827-35.
2001: Steven F Sukits; Lih-Ling Lin; Sang Hsu; Karl Malakian; Robert Powers; GY Xu
Solution structure of the tumor necrosis factor receptor-1 death domain.
Journal of molecular biology 2001;310(4):895-906.
2000: Jean-Baptiste Telliez; GY Xu; J D Woronicz; Sang Hsu; J L Wu; L Lin; Steven F Sukits; Robert Powers; Lih-Ling Lin
Mutational analysis and NMR studies of the death domain of the tumor necrosis factor receptor-1.
Journal of molecular biology 2000;300(5):1323-33.
2000: Desirée H H Tsao; T McDonagh; Jean-Baptiste Telliez; Sang Hsu; Karl Malakian; GY Xu; Lih-Ling Lin
Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.
Molecular cell 2000;5(6):1051-7.
1998: Kathryn W Underwood; C Song; Ron Kriz; X J Chang; J L Knopf; Lih-Ling Lin
A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2.
The Journal of biological chemistry 1998;273(34):21926-32.
1997: A R Schievella; J H Chen; J R Graham; Lih-Ling Lin
MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.
The Journal of biological chemistry 1997;272(18):12069-75.
1995: A R Schievella; M K Regier; W L Smith; Lih-Ling Lin
Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum.
The Journal of biological chemistry 1995;270(51):30749-54.
1995: J D Clark; A R Schievella; Eric A Nalefski; Lih-Ling Lin
Cytosolic phospholipase A2.
Journal of lipid mediators and cell signalling 1995;12(2-3):83-117.
1993: Lih-Ling Lin; M Wartmann; A Y Lin; J L Knopf; A Seth; R J Davis
cPLA2 is phosphorylated and activated by MAP kinase.
Cell 1993;72(2):269-78.
1992: Lih-Ling Lin; A Y Lin; D L DeWitt
Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.
The Journal of biological chemistry 1992;267(33):23451-4.
1992: Lih-Ling Lin; A Y Lin; J L Knopf
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6147-51.
1991: J D Clark; Lih-Ling Lin; Ron Kriz; C S Ramesha; L A Sultzman; A Y Lin; N Milona; J L Knopf
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP.
Cell 1991;65(6):1043-51.