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Li-Ping Lin

Research Profile

Anatomy

Living Beings

Physiology

Procedures

Drug Screening Assays, Antitumor

Genes & Molecular Sequences

Molecular Structure

Chemicals & Drugs

Disorders

Leukemia P388

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Publications

TOP 3
Jin-gui Ma; Xian-liang Xin; Si-meng Chen; Yi Chen; Jian Ding; He Huang; Li-Ping Lin; Hong Liu; Ling-Hua Meng
PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.
Mei Dai; Ze-Hong Miao; Xuan Ren; Lin-Jiang Tong; Na Yang; Ting Li; Li-Ping Lin; Yue-Mao Shen; Jian Ding
MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition.
Jin-Jian Lu; Ling-Hua Meng; Uma Shankavaram; Cai-Hua Zhu; Lin-Jiang Tong; Guang Chen; Li-Ping Lin; John N Weinstein; Jian Ding
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.

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All Publications

2011: Jin-gui Ma; Xian-liang Xin; Si-meng Chen; Yi Chen; Jian Ding; He Huang; Li-Ping Lin; Hong Liu; Ling-Hua Meng
PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.
Breast cancer research and treatment 2011;130(1):85-96.
2010: Mei Dai; Ze-Hong Miao; Xuan Ren; Lin-Jiang Tong; Na Yang; Ting Li; Li-Ping Lin; Yue-Mao Shen; Jian Ding
MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition.
Journal of cellular and molecular medicine 2010;14(9):2281-91.
2010: Jin-Jian Lu; Ling-Hua Meng; Uma Shankavaram; Cai-Hua Zhu; Lin-Jiang Tong; Guang Chen; Li-Ping Lin; John N Weinstein; Jian Ding
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.
Biochemical pharmacology 2010;80(1):22-30.
2010: Jing Zhang; Yi Chen; Xian-liang Xin; Qiu-ning Li; Ming Li; Li-Ping Lin; Mei-yu Geng; Jian Ding
Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation.
Acta pharmacologica Sinica 2010;31(3):375-81.
2009: Xuan Ren; Mei Dai; Li-Ping Lin; Pui-Kai Li; Jian Ding
Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent.
British journal of pharmacology 2009;156(8):1228-38.
2008: Hai-hong Li; He Huang; Xiu-hua Zhang; Xiao-Min Luo; Li-Ping Lin; Hua-Liang Jiang; Jian Ding; Kai-xian Chen; Hong Liu
Discovering novel 3-nitroquinolines as a new class of anticancer agents.
Acta pharmacologica Sinica 2008;29(12):1529-38.
2008: Yu-Jun Cai; Jin-Jian Lu; Hong Zhu; Hua Xie; Min Huang; Li-Ping Lin; Xiong-Wen Zhang; Jian Ding
Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition.
Free radical biology & medicine 2008;45(5):627-35.
2008: Jin-Jian Lu; Ling-Hua Meng; Yu-Jun Cai; Qin Chen; Lin-Jiang Tong; Li-Ping Lin; Jian Ding
Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species.
Cancer biology & therapy 2008;7(7):1017-23.
2008: Zhen-Qiang Xin; Jing-Jian Lu; Chang-Qiang Ke; Chao-Xin Hu; Li-Ping Lin; Yang Ye
Constituents from Clausena excavata.
Chemical & pharmaceutical bulletin 2008;56(6):827-30.
2008: Jun Huo; Sheng-Ping Yang; Bo-Jun Xie; Shang-Gao Liao; Li-Ping Lin; Jian Ding; Jian-Min Yue
Cytotoxic sesquiterpenoids from Vernonia bockiana.
Journal of Asian natural products research 2008;10(5-6):571-5.
2008: Juan-juan Chen; Xiao-yu Su; Xiao-dong Xi; Li-Ping Lin; Jian Ding; He Lu
Fibrinogen interaction of CHO cells expressing chimeric alphaIIb/alphavbeta3 integrin.
Acta pharmacologica Sinica 2008;29(2):204-10.
2008: Sheng-Ping Yang; Yu-Jun Cai; Bang-le Zhang; Lin-Jiang Tong; Hua Xie; Yan Wu; Li-Ping Lin; Jian Ding; Jian-Min Yue
Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure-activity relationship study.
Journal of medicinal chemistry 2008;51(1):77-85.
2008: Qin Chen; Ling-Hua Meng; Cai-Hua Zhu; Li-Ping Lin; He Lu; Jian Ding
ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation.
The international journal of biochemistry & cell biology 2008;40(10):2164-73.
2007: Cheng-Ying Xie; Hong Zhu; Li-Ping Lin; Ze-Hong Miao; Meiyu Geng; Yu-Jun Cai; Yi Chen; Hua-Jun Zhao; Hai-Bin Luo; Xiong-Wen Zhang; Li-Ming Fan; Yue-Mao Shen; Jian Ding
MFTZ-1, an actinomycetes subspecies derived antitumor macrolide, functions as a novel topoisomerase II poison.
Molecular cancer therapeutics 2007;6(11):3059-70.
2007: Xiu-Hua Zhang; Xiao-Ning Guo; Li Zhong; Xiao-Min Luo; Hua-Liang Jiang; Li-Ping Lin; Jian Ding
Establishment of the active catalytic domain of human PDGFRbeta tyrosine kinase-based ELISA assay for inhibitor screening.
Biochimica et biophysica acta 2007;1770(10):1490-7.
2007: Fang Tian; Cai-hua Zhu; Xiong-Wen Zhang; Xin Xie; Xian-liang Xin; Yang-Hua Yi; Li-Ping Lin; Meiyu Geng; Jian Ding
Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and alphavbeta3 integrin via binding to the extracellular domain of KDR.
Molecular pharmacology 2007;72(3):545-52.
2007: Xiao-Hong Yan; Li-Ping Lin; Jian Ding; Yue-Wei Guo
Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp.
Bioorganic & medicinal chemistry letters 2007;17(9):2661-3.
2007: Jiao-Long Fu; Chang-Heng TAN; Li-Ping Lin; Ji Huang; Da-Yuan Zhu
Fibrarecisin, a novel triterpenoid from Fibraurea recisa with antitumor activity.
Natural product research 2007;21(4):351-3.
2007: Sheng Yin; Xiao-Ning Wang; Cheng-Qi Fan; Li-Ping Lin; Jian Ding; Jian-Min Yue
Limonoids from the seeds of the marine mangrove Xylocarpus granatum.
Journal of natural products 2007;70(4):682-5.
2007: Hua Zhang; Xiao-Ning Wang; Li-Ping Lin; Jian Ding; Jian-Min Yue
Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua.
Journal of natural products 2007;70(1):54-9.
2007: Hai-Hong Li; Xiu-Hua Zheng; Jin-zhi Tan; Li-Li Chen; Hong Liu; Xiao-Min Luo; Xu Shen; Li-Ping Lin; Kai-Xian Chen; Jian Ding; Hua-Liang Jiang
Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives.
Acta pharmacologica Sinica 2007;28(1):140-52.
2006: Chao-Xin Hu; Zhi-Li Zuo; Bing Xiong; Jin-Gui Ma; Meiyu Geng; Li-Ping Lin; Hua-Liang Jiang; Jian Ding
Salvicine functions as novel topoisomerase II poison by binding to ATP pocket.
Molecular pharmacology 2006;70(5):1593-601.
2006: Sheng Yin; Cheng-Qi Fan; Xiao-Ning Wang; Li-Ping Lin; Jian Ding; Jian-Min Yue
Xylogranatins A-D: novel tetranortriterpenoids with an unusual 9,10-seco scaffold from marine mangrove Xylocarpus granatum.
Organic letters 2006;8(21):4935-8.
2006: You-Kai Xu; Sheng-Ping Yang; Shang-Gao Liao; Hua Zhang; Li-Ping Lin; Jian Ding; Jian-Min Yue
Alkaloids from Gelsemium elegans.
Journal of natural products 2006;69(9):1347-50.
2006: Jian Li; Jin-zhi Tan; Li-li Chen; Zhang Jian; Xu Shen; Chang-lin Mei; Li-li Fu; Li-Ping Lin; Jian Ding; Bing Xiong; Xi-shan Xiong; Hong Liu; Xiao-Min Luo; Hua-Liang Jiang
Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives.
Acta pharmacologica Sinica 2006;27(9):1259-71.
2006: Xiao-Ning Wang; Sheng Yin; Cheng-Qi Fan; Fang-Dao Wang; Li-Ping Lin; Jian Ding; Jian-Min Yue
Turrapubesins A and B, first examples of halogenated and maleimide-bearing limonoids in nature from Turraea pubescens.
Organic letters 2006;8(17):3845-8.
2006: Yan Gao; Li-Ping Lin; Cai-Hua Zhu; Yi Chen; Yong-Tai Hou; Jian Ding
Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma.
Cancer biology & therapy 2006;5(8):978-85.
2006: Chao Zhang; Fan Yang; Xiong-Wen Zhang; Shun-Chun Wang; Mei-Hong Li; Li-Ping Lin; Jian Ding
Grateloupia longifolia polysaccharide inhibits angiogenesis by downregulating tissue factor expression in HMEC-1 endothelial cells.
British journal of pharmacology 2006;148(6):741-51.
2006: Li-She Gan; Cheng-Qi Fan; Sheng-Ping Yang; Yan Wu; Li-Ping Lin; Jian Ding; Jian-Min Yue
Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa.
Organic letters 2006;8(11):2285-8.
2006: Yun-Guang Tong; Xiong-Wen Zhang; Meiyu Geng; Jian-Min Yue; Xian-liang Xin; Fang Tian; Xu Shen; Lin-Jiang Tong; Mei-Hong Li; Chao Zhang; Wei-Hong Li; Li-Ping Lin; Jian Ding
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin.
Molecular pharmacology 2006;69(4):1226-33.
2006: Li Zhong; Xiao-Ning Guo; Xiu-Hua Zhang; Qi-Ming Sun; Lin-Jiang Tong; Zhi-Xing Wu; Xiao-Min Luo; Hua-Liang Jiang; Fa-Jun Nan; Xiong-Wen Zhang; Li-Ping Lin; Jian Ding
TKI-31 inhibits angiogenesis by combined suppression signaling pathway of VEGFR2 and PDGFRbeta.
Cancer biology & therapy 2006;5(3):323-30.
2005: Xiao-Ning Guo; Li Zhong; Jin-zhi Tan; Jian Li; Xiao-Min Luo; Hua-Liang Jiang; Fa-Jun Nan; Li-Ping Lin; Xiong-Wen Zhang; Jian Ding
In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects.
Cancer biology & therapy 2005;4(10):1125-32.
2005: Yi Jin; Huiyuan Li; Li-Ping Lin; Jinzhi Tan; Jian Ding; Xiaomin Luo; Ya-Qiu Long
Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors.
Bioorganic & medicinal chemistry 2005;13(19):5613-22.
2005: Yi-Xiang Zhang; Yi Chen; Xiao-Ning Guo; Xiong-Wen Zhang; Wei-Min Zhao; Li Zhong; Jin Zhou; Yong Xi; Li-Ping Lin; Jian Ding
11,11'-dideoxy-verticillin: a natural compound possessing growth factor receptor tyrosine kinase-inhibitory effect with anti-tumor activity.
Anti-cancer drugs 2005;16(5):515-24.
2005: Jing-Yu Lang; Hua Chen; Jin Zhou; Yi-Xiang Zhang; Xiong-Wen Zhang; Mei-Hong Li; Li-Ping Lin; Jin-Sheng Zhang; Michael P Waalkes; Jian Ding
Antimetastatic effect of salvicine on human breast cancer MDA-MB-435 orthotopic xenograft is closely related to Rho-dependent pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3455-64.
2005: Yi Chen; Yi-Xiang Zhang; Mei-Hong Li; Wei-Min Zhao; Yu-Hua Shi; Ze-Hong Miao; Xiong-Wen Zhang; Li-Ping Lin; Jian Ding
Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola.
Biochemical and biophysical research communications 2005;329(4):1334-42.
2005: Li Zhong; Xiao-Ning Guo; Xiu-Hua Zhang; Zhi-Xing Wu; Xiao-Min Luo; Hua-Liang Jiang; Li-Ping Lin; Xiong-Wen Zhang; Jian Ding
Expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 for inhibitor screening.
Biochimica et biophysica acta 2005;1722(3):254-61.
2005: Da-Yong Lu; Min Huang; Cheng Hui Xu; Wei Yi Yang; Chao Xin Hu; Li-Ping Lin; Lin Jiang Tong; Mei Hong Li; Wei Lu; Xiong Wen Zhang; Jian Ding
Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines.
BMC pharmacology 2005;5():11.
2004: Mei-Hong Li; Ze-Hong Miao; Wen-Fu Tan; Jian-Min Yue; Chao Zhang; Li-Ping Lin; Xiong-Wen Zhang; Jian Ding
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8266-74.
2004: Wen-Fu Tan; Xiong-Wen Zhang; Mei-Hong Li; Jian-Min Yue; Yi Chen; Li-Ping Lin; Jian Ding
Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect.
European journal of pharmacology 2004;499(3):219-28.
2004: Da-Yong Lu; J Chi; Li-Ping Lin; Min Huang; Bin Xu; Jian Ding
Effect of anti-cancer drugs on the binding of 125I-Fibrinogen to two leukaemia cell lines in vitro.
The Journal of international medical research 2004;32(5):488-91.
2004: Xiao-Ning Guo; Li Zhong; Xiu-Hua Zhang; Wei-Min Zhao; Xiong-Wen Zhang; Li-Ping Lin; Jian Ding
Evaluation of active recombinant catalytic domain of human ErbB-2 tyrosine kinase, and suppression of activity by a naturally derived inhibitor, ZH-4B.
Biochimica et biophysica acta 2004;1673(3):186-93.
2004: Xiao-Chun Huang; Di Zhao; Yue-Wei Guo; Hou-Ming Wu; Li-Ping Lin; Zhong-Hua Wang; Jian Ding; Yong-Shui Lin
Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.
Bioorganic & medicinal chemistry letters 2004;14(12):3117-20.
2003: Wen-Fu Tan; Li-Ping Lin; Mei-hong Li; Yi-Xiang Zhang; Yun-guang Tong; Dong Xiao; Jian Ding
Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.
European journal of pharmacology 2003;459(2-3):255-62.