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Pin-Fang Lin

Research Profile

Living Beings

Chemicals & Drugs

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HIV Infections

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Publications

TOP 3
John A Bender; Betsy Eggers; Yi-Fei Gong; Pin-Fang Lin; Nicholas A Meanwell; Dawn D Parker; Sandhya Rahematpura; Zhong Yang; Ming Zheng; John F Kadow
Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
Tao Wang; Zhong Yang; Zhongxing Zhang; Ming Zheng; Yi-Fei Gong; John F Kadow; Pin-Fang Lin; Marina Mathew; Nicholas A Meanwell; Dawn D Parker; Sandhya Rahematpura; Keith A Riccardi; John A Bender
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Kap-Sun Yeung; Lisa Zadjura; Marc R Browning; Celia J D'Arienzo; Betsy J Eggers; Haiquan Fang; Qi Gao; Yi-Fei Gong; Steven B Hansel; Pin-Fang Lin; Nicholas A Meanwell; Zhilei Qiu; Keith Riccardi; Kenneth Santone; Pei-Yong Shi; Quifen Xue; Zheng Yang; John F Kadow
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.

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2013: John A Bender; Betsy Eggers; Yi-Fei Gong; Pin-Fang Lin; Nicholas A Meanwell; Dawn D Parker; Sandhya Rahematpura; Zhong Yang; Ming Zheng; John F Kadow
Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
Bioorganic & medicinal chemistry letters 2013;23(1):218-22.
2013: Tao Wang; Zhong Yang; Zhongxing Zhang; Ming Zheng; Yi-Fei Gong; John F Kadow; Pin-Fang Lin; Marina Mathew; Nicholas A Meanwell; Dawn D Parker; Sandhya Rahematpura; Keith A Riccardi; John A Bender
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Bioorganic & medicinal chemistry letters 2013;23(1):213-7.
2013: Kap-Sun Yeung; Lisa Zadjura; Marc R Browning; Celia J D'Arienzo; Betsy J Eggers; Haiquan Fang; Qi Gao; Yi-Fei Gong; Steven B Hansel; Pin-Fang Lin; Nicholas A Meanwell; Zhilei Qiu; Keith Riccardi; Kenneth Santone; Pei-Yong Shi; Quifen Xue; Zheng Yang; John F Kadow
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorganic & medicinal chemistry letters 2013;23(1):198-202.
2013: Kap-Sun Yeung; Zhiwei Yin; Lisa Zadjura; Jonathan Barker; Marc R Browning; Thomas Coulter; Celia J D'Arienzo; Haiquan Fang; Yi-Fei Gong; Steven B Hansel; Pin-Fang Lin; Nicholas A Meanwell; Bradley Pearce; Zhilei Qiu; Keith Riccardi; Kenneth Santone; Pei-Yong Shi; Timothy P Spicer; Ashok Trehan; Zheng Yang; John F Kadow
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(1):203-8.
2013: Kap-Sun Yeung; Lisa Zadjura; Marc R Browning; Celia J D'Arienzo; Betsy J Eggers; Steven B Hansel; Xiaohua Stella Huang; Pin-Fang Lin; Nicholas A Meanwell; Zhilei Qiu; Keith Riccardi; Zheng Yang; John F Kadow
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorganic & medicinal chemistry letters 2013;23(1):209-12.
2012: Beata Nowicka-Sans; Neelanjana Ray; David Stock; Yasutsugu Ueda; Tao Wang; Megan Wind-Rotolo; Nannan Zhou; Li Zhu; ira dicker; Betsy Eggers; Yi-Fei Gong; George J Hanna; Hsu-Tso Ho; John F Kadow; Max Lataillade; Pin-Fang Lin; Antara Majumdar; John D Matiskella; Brian McAuliffe; Nicholas A Meanwell; Mark Krystal
In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068.
Antimicrobial agents and chemotherapy 2012;56(7):3498-507.
2012: John F Kadow; Pin-Fang Lin; Marina Mathew; Nicholas A Meanwell; Daniel Morgan; Dawn Parker; Yasutsugu Ueda; Tao Wang; Zhong Yang; Kap-Sun Yeung; Ming Zheng; Juliang Zhu; John A Bender; Chung-Pin Chen; Caly Chien; Richard J Colonno; Timothy P Connolly; Dennis Grasela
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043).
Journal of medicinal chemistry 2012;55(5):2048-56.
2011: Nannan Zhou; Beata Nowicka-Sans; Sharon Zhang; Li Fan; Jie Fang; Hua Fang; Yi-Fei Gong; Betsy Eggers; David R Langley; Tao Wang; John Kadow; Dennis Grasela; George J Hanna; Louis Alexander; Richard Colonno; Mark Krystal; Pin-Fang Lin
In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.
Antimicrobial agents and chemotherapy 2011;55(2):729-37.
2010: Nannan Zhou; Li Fan; Hsu-Tso Ho; Beata Nowicka-Sans; Yongnian Sun; Yingjie Zhu; Yanhua Hu; Brian McAuliffe; Burt Rose; Hua Fang; Tao Wang; John Kadow; Mark Krystal; Louis Alexander; Richard Colonno; Pin-Fang Lin
Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.
Virology 2010;402(2):256-61.
2010: Sharon Zhang; Louis Alexander; Tao Wang; Michele Agler; Nannon Zhou; Hua Fang; John Kadow; Paul Clapham; Pin-Fang Lin
Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors.
Archives of virology 2010;155(5):777-81.
2010: Zheng Yang; Lisa Zadjura; Anthony M Marino; Celia D'Arienzo; Jacek Malinowski; Christoph Gesenberg; Pin-Fang Lin; Richard J Colonno; Tao Wang; John F Kadow; Nicholas A Meanwell; Steven B Hansel
Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
Journal of pharmaceutical sciences 2010;99(4):2135-52.
2009: Tao Wang; John F Kadow; Zhongxing Zhang; Zhiwei Yin; Qi Gao; Dedong Wu; Dawn DiGiugno Parker; Zheng Yang; Lisa Zadjura; Brett A Robinson; Yi-Fei Gong; Timothy P Spicer; Wade S Blair; Pei-Yong Shi; Gregory Yamanaka; Pin-Fang Lin; Nicholas A Meanwell
Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.
Bioorganic & medicinal chemistry letters 2009;19(17):5140-5.
2009: Nicholas A Meanwell; Owen B Wallace; Henry Wang; MS Deshpande; Bradley C Pearce; Ashok Trehan; Kap-Sun Yeung; Zhilei Qiu; J J Kim Wright; Brett A Robinson; Yi-Fei Gong; Hwei-Gene Heidi Wang; Timothy P Spicer; Wade S Blair; Pei-Yong Shi; Pin-Fang Lin
Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity.
Bioorganic & medicinal chemistry letters 2009;19(17):5136-9.
2009: Nicholas A Meanwell; Owen B Wallace; Haiquan Fang; Henry Wang; MS Deshpande; Tao Wang; Zhiwei Yin; Zhongxing Zhang; Bradley C Pearce; Jennifer James; Kap-Sun Yeung; Zhilei Qiu; J J Kim Wright; Zheng Yang; Lisa Zadjura; Donald L Tweedie; Suresh Yeola; Fang Zhao; Sunanda Ranadive; Brett A Robinson; Yi-Fei Gong; Hwei-Gene Heidi Wang; Timothy P Spicer; Wade S Blair; Pei-Yong Shi; Richard J Colonno; Pin-Fang Lin
Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.
Bioorganic & medicinal chemistry letters 2009;19(7):1977-81.
2008: Pin-Fang Lin; Beata Nowicka-Sans; Brian Terry; Sharon Zhang; Chunfu Wang; Li Fan; ira dicker; Volodymyr Gali; Helen Higley; Neil Parkin; Daniel J Tenney; Mark Krystal; Richard J Colonno
Entecavir exhibits inhibitory activity against human immunodeficiency virus under conditions of reduced viral challenge.
Antimicrobial agents and chemotherapy 2008;52(5):1759-67.
2007: Herbert E Klei; Kevin Kish; Pin-Fang Lin; Qi Guo; Jacques Friborg; Ronald E Rose; Yaqun Zhang; Valentina Goldfarb; David R Langley; Michael Wittekind; Steven Sheriff
X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir.
Journal of virology 2007;81(17):9525-35.
2006: John F Kadow; Hwei-Gene Heidi Wang; Pin-Fang Lin
Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: an emerging opportunity for drug development.
Current opinion in investigational drugs (London, England : 2000) 2006;7(8):721-6.
2006: Hsu-Tso Ho; Li Fan; Beata Nowicka-Sans; Brian McAuliffe; Chang-Ben Li; Gregory Yamanaka; Nannan Zhou; Hua Fang; ira dicker; Richard A Dalterio; Yi-Fei Gong; Tao Wang; Zhiwei Yin; Yasutsugu Ueda; John Matiskella; John F Kadow; Paul Clapham; James Robinson; Richard J Colonno; Pin-Fang Lin
Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events.
Journal of virology 2006;80(8):4017-25.
2005: Zheng Yang; Lisa Zadjura; Celia D'Arienzo; Anthony Marino; Kenneth Santone; Lewis Klunk; Douglas Greene; Pin-Fang Lin; Richard J Colonno; Tao Wang; Nicholas A Meanwell; Steven Hansel
Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics.
Biopharmaceutics & drug disposition 2005;26(9):387-402.
2004: Hwei-Gene Heidi Wang; R E Williams; Pin-Fang Lin
A novel class of HIV-1 inhibitors that targets the viral envelope and inhibits CD4 receptor binding.
Current pharmaceutical design 2004;10(15):1785-93.
2003: Qi Guo; Hsu-Tso Ho; ira dicker; Li Fan; Nannan Zhou; Jacques Friborg; Tao Wang; Brian V McAuliffe; Hwei-Gene Heidi Wang; Ronald E Rose; Hua Fang; Helen T Scarnati; David R Langley; Nicholas A Meanwell; Ralph Abraham; Richard J Colonno; Pin-Fang Lin
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.
Journal of virology 2003;77(19):10528-36.
2003: Tao Wang; Zhongxing Zhang; Owen B Wallace; Milind Deshpande; Haiquan Fang; Zheng Yang; Lisa Zadjura; Donald L Tweedie; Stella Huang; Fang Zhao; Sunanda Ranadive; Brett S Robinson; Yi-Fei Gong; Keith Ricarrdi; Timothy P Spicer; Carol Deminie; Ronald Rose; Hwei-Gene Heidi Wang; Wade S Blair; Pei-Yong Shi; Pin-Fang Lin; Richard J Colonno; Nicholas A Meanwell
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
Journal of medicinal chemistry 2003;46(20):4236-9.
2003: Pin-Fang Lin; Wade S Blair; Tao Wang; Timothy P Spicer; Qi Guo; Nannan Zhou; Yi-Fei Gong; Hwei-Gene Heidi Wang; Ronald Rose; Gregory Yamanaka; Brett Robinson; Chang-Ben Li; Robert Fridell; Carol Deminie; Gwendeline Demers; Zheng Yang; Lisa Zadjura; Nicholas A Meanwell; Richard J Colonno
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):11013-8.
2000: A D Pivazyan; D S Matteson; L Fabry-Asztalos; R P Singh; Pin-Fang Lin; Wade S Blair; K Guo; B Robinson; WH Prusoff
Inhibition of HIV-1 protease by a boron-modified polypeptide.
Biochemical pharmacology 2000;60(7):927-36.
2000: Yi-Fei Gong; Brett S Robinson; Ronald E Rose; Carol Deminie; Timothy P Spicer; D Stock; Richard J Colonno; Pin-Fang Lin
In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS-232632.
Antimicrobial agents and chemotherapy 2000;44(9):2319-26.
2000: Brett S Robinson; K A Riccardi; Yi-Fei Gong; Qi Guo; D A Stock; Wade S Blair; B J Terry; Carol Deminie; F Djang; Richard J Colonno; Pin-Fang Lin
BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents.
Antimicrobial agents and chemotherapy 2000;44(8):2093-9.
1999: Pin-Fang Lin; C J González; B Griffith; G Friedland; V Calvez; F Ferchal; Ray F Schinazi; D H Shepp; A B Ashraf; M A Wainberg; V Soriano; J W Mellors; Richard J Colonno
Stavudine resistance: an update on susceptibility following prolonged therapy.
Antiviral therapy 1999;4(1):21-8.
1998: Carol Deminie; C M Bechtold; K Riccardi; Ronald E Rose; H Samanta; Pin-Fang Lin; Richard J Colonno
Clinical HIV-1 isolates remain sensitive to stavudine following prolonged therapy.
AIDS (London, England) 1998;12(1):110-2.
1996: C A Deminie; C M Bechtold; D Stock; M Alam; F Djang; A H Balch; T C Chou; Mark Prichard; Richard J Colonno; Pin-Fang Lin
Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication.
Antimicrobial agents and chemotherapy 1996;40(6):1346-51.
1996: P Chen; P T Cheng; M Alam; B D Beyer; Gregory S Bisacchi; T Dejneka; A J Evans; J A Greytok; Mark Hermsmeier; W G Humphreys; G A Jacobs; O Kocy; Pin-Fang Lin; K A Lis; M A Marella; Denis E Ryono; AK Sheaffer; S H Spergel; C Q Sun; J A Tino; G Vite; Richard J Colonno; Robert Zahler; J C Barrish
Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.
Journal of medicinal chemistry 1996;39(10):1991-2007.
1996: Y F Gong; C M Bechtold; B S Robinson; Pin-Fang Lin
Potentiation of the stavudine anti-human immunodeficiency virus activity by 5-fluorouracil.
Antimicrobial agents and chemotherapy 1996;40(5):1329.
1996: G A Warr; JA Veitch; A W Walsh; G A Hesler; D M Pirnik; J E Leet; Pin-Fang Lin; Ivette Medina; K D McBrien; S Forenza; J M Clark; Kin S Lam
BMS-182123, a fungal metabolite that inhibits the production of TNF-alpha by macrophages and monocytes.
The Journal of antibiotics 1996;49(3):234-40.
1996: R E Rose; Y F Gong; J A Greytok; C M Bechtold; B J Terry; B S Robinson; M Alam; Richard J Colonno; Pin-Fang Lin
Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1648-53.
1996: Jingfang Qian-Cutrone; Stella Huang; J Trimble; H Li; Pin-Fang Lin; M Alam; Steven E Klohr; K F Kadow
Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri.
Journal of natural products 1996;59(2):196-9.
1996: Pin-Fang Lin; H Samanta; C M Bechtold; C A Deminie; A K Patick; M Alam; K Riccardi; R E Rose; R J White; Richard J Colonno
Characterization of siamycin I, a human immunodeficiency virus fusion inhibitor.
Antimicrobial agents and chemotherapy 1996;40(1):133-8.
1995: D J Detlefsen; S E Hill; KJ Volk; Steven E Klohr; M Tsunakawa; T Furumai; Pin-Fang Lin; M Nishio; K Kawano; T Oki
Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I.
The Journal of antibiotics 1995;48(12):1515-7.
1995: A K Patick; R Rose; J Greytok; C M Bechtold; Mark Hermsmeier; P T Chen; J C Barrish; Robert Zahler; Richard J Colonno; Pin-Fang Lin
Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor.
Journal of virology 1995;69(4):2148-52.
1994: Pin-Fang Lin; H Samanta; R E Rose; A K Patick; J Trimble; C M Bechtold; D R Revie; N C Khan; M E Federici; H Li
Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy.
The Journal of infectious diseases 1994;170(5):1157-64.
1994: J C Barrish; E Gordon; M Alam; Pin-Fang Lin; Gregory S Bisacchi; P Chen; P T Cheng; A W Fritz; J A Greytok; Mark Hermsmeier
Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR.
Journal of medicinal chemistry 1994;37(12):1758-68.
1993: M Alam; C M Bechtold; A K Patick; M T Skoog; T G Gant; Richard J Colonno; A I Meyers; H Li; J Trimble; Pin-Fang Lin
Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors.
Antiviral research 1993;22(2-3):131-41.
1989: J V Desiderio; Peter Kiener; Pin-Fang Lin; G A Warr
Protection of mice against Listeria monocytogenes infection by recombinant human tumor necrosis factor alpha.
Infection and immunity 1989;57(5):1615-7.
1988: Peter Kiener; F Marek; G Rodgers; Pin-Fang Lin; G Warr; J Desiderio
Induction of tumor necrosis factor, IFN-gamma, and acute lethality in mice by toxic and non-toxic forms of lipid A.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):870-4.