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Paul Barlow

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TOP 3
Christoph Q Schmidt; Hongjun Bai; Paul N Barlow; Zhuoer Lin; Daniel Ricklin; Antonio M Risitano; John D Lambris
Rational engineering of a minimized immune inhibitor with unique triple-targeting properties.
Hongchang Qu; Edimara S Reis; Ranillo R G Resuello; Daniel Ricklin; Apostolia Tzekou; Hongjun Bai; Paul N Barlow; Hui Chen; Robert A DeAngelis; Florea Lupu; Mateusz Maciejewski; John D Lambris
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.
Allison M Lesher; Takashi Miwa; Sayaka Sato; Christina Skerka; Paul N Barlow; Hannes U Eberhardt; Damodar Gullipalli; Takayuki Hamano; Andrew Herbert; Yuko Kimura; Kenneth S Tung; Lin Zhou; Peter F Zipfel; Wen-Chao Song
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.

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All Publications

2013: Christoph Q Schmidt; Hongjun Bai; Paul N Barlow; Zhuoer Lin; Daniel Ricklin; Antonio M Risitano; John D Lambris
Rational engineering of a minimized immune inhibitor with unique triple-targeting properties.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(11):5712-21.
2013: Hongchang Qu; Edimara S Reis; Ranillo R G Resuello; Daniel Ricklin; Apostolia Tzekou; Hongjun Bai; Paul N Barlow; Hui Chen; Robert A DeAngelis; Florea Lupu; Mateusz Maciejewski; John D Lambris
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.
Immunobiology 2013;218(4):496-505.
2013: Allison M Lesher; Takashi Miwa; Sayaka Sato; Christina Skerka; Paul N Barlow; Hannes U Eberhardt; Damodar Gullipalli; Takayuki Hamano; Andrew Herbert; Yuko Kimura; Kenneth S Tung; Lin Zhou; Peter F Zipfel; Wen-Chao Song
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2013;24(1):53-65.
2012: Elisavet Makou; Ilias Matis; Haydyn D T Mertens; Christoph Q Schmidt; Dinesh C Soares; Dmitri I Svergun; Andrew Herbert; Mateusz Maciejewski; Paul N Barlow
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H.
Journal of molecular biology 2012;424(5):295-312.
2012: Timothy H J Goodship; Claire L Harris; Christine Hayes; Andrew Herbert; Kris Houlberg; Eva-Maria Hunze; David Kavanagh; Frances McCormick; Iain Moore; Isabel Y Pappworth; Christoph Q Schmidt; Scott J Staniforth; Lisa Strain; Tibor Toth; David Warland; Paul N Barlow; Danielle Paixão Cavalcante; Mark Denton; Kevin J Marchbank
Factor H autoantibodies in membranoproliferative glomerulonephritis.
Molecular immunology 2012;52(3-4):200-6.
2012: Dinesh C Soares; Malcolm D Walkinshaw; Martin A Wear; Juan Zou; Juri Rappsilber; Paul N Barlow; Elizabeth A Blackburn; Bettina Böttcher; Nicholas Bradshaw; Janice Bramham; Zhuo A Chen; Russell S Hamilton; Christopher K Kennaway; J Kirsty Millar; David J Porteous
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
The Journal of biological chemistry 2012;287(39):32381-93.
2012: Andrew Herbert; Conny Johansson; David Kavanagh; Hugh P Morgan; Paul N Barlow; Bärbel S Blaum; Jonathan P Hannan; Dusan Uhrín
Structural and functional characterization of the product of disease-related factor H gene conversion.
Biochemistry 2012;51(9):1874-84.
2012: Patience B Tetteh-Quarcoo; Wai-Hong Tham; John P Atkinson; Alan F Cowman; Richard Hauhart; Haydyn D T Mertens; Arthur Rowe; J Alexandra Rowe; Christoph Q Schmidt; Paul N Barlow
Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.
PloS one 2012;7(4):e34820.
2012: Hugh P Morgan; Christoph Q Schmidt; Dinesh C Soares; Dmitri I Svergun; Paul N Barlow; Mara Guariento; Andrew Herbert; Haydyn D T Mertens; Jonathan P Hannan
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH).
PloS one 2012;7(2):e32187.
2011: Isabell C Pechtl; David T F Dryden; Anita C Jones; Robert K Neely; Paul N Barlow
Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus).
Protein science : a publication of the Protein Society 2011;20(12):2102-12.
2011: Wai-Hong Tham; John P Atkinson; Paul N Barlow; Mara Guariento; Richard E Hauhart; Sash Lopaticki; Christoph Q Schmidt; Patience B Tetteh-Quarcoo; Alan F Cowman
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes.
Blood 2011;118(7):1923-33.
2011: Hugh P Morgan; Dusan Uhrin; Paul N Barlow; Andrew Herbert; Jingzi Jiang; David Kavanagh; Jonathan P Hannan
Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 7):593-600.
2011: Hugh P Morgan; Christoph Q Schmidt; Mara Guariento; Bärbel S Blaum; Dominic Gillespie; Andrew Herbert; David Kavanagh; Haydyn D T Mertens; Dmitri I Svergun; Conny M Johansson; Dusan Uhrín; Paul N Barlow; Jonathan P Hannan
Structural basis for engagement by complement factor H of C3b on a self surface.
Nature structural & molecular biology 2011;18(4):463-70.
2011: Isabell C Pechtl; David Kavanagh; Nicola McIntosh; Claire L Harris; Paul N Barlow
Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.
The Journal of biological chemistry 2011;286(13):11082-90.
2011: Christoph Q Schmidt; Fern C Slingsby; Anna Richards; Paul N Barlow
Production of biologically active complement factor H in therapeutically useful quantities.
Protein expression and purification 2011;76(2):254-63.
2010: Maria C Sanchez; Jonathan G Renshaw; Gareth Davies; Paul N Barlow; Martin Vogtherr
MDM4 binds ligands via a mechanism in which disordered regions become structured.
FEBS letters 2010;584(14):3035-41.
2010: Bärbel S Blaum; Jon A Deakin; Conny M Johansson; Andrew Herbert; Paul N Barlow; Malcolm Lyon; Dusan Uhrín
Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.
Journal of the American Chemical Society 2010;132(18):6374-81.
2010: Christoph Q Schmidt; Andrew Herbert; Haydyn D T Mertens; Mara Guariento; Dinesh C Soares; Dusan Uhrin; Arthur J Rowe; Dmitri I Svergun; Paul N Barlow
The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module.
Journal of molecular biology 2010;395(1):105-22.
2009: Marie M Phelan; Chuong-Thu Thai; Dinesh C Soares; Ronald T Ogata; Paul N Barlow; Janice Bramham
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.
The Journal of biological chemistry 2009;284(29):19637-49.
2009: Marie M Phelan; Chuong-Thu Thai; Andrew Herbert; Juraj Bella; Dusan Uhrín; Ronald T Ogata; Paul N Barlow; Janice Bramham
1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.
Biomolecular NMR assignments 2009;3(1):49-52.
2009: Viviana Ferreira; Andrew Herbert; Claudio Cortés; Kristi A McKee; Bärbel S Blaum; Stefan T Esswein; Dusan Uhrín; Paul N Barlow; Michael K Pangburn; David Kavanagh
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):7009-18.
2008: Kendra A Young; Andrew Herbert; Paul N Barlow; V Michael Holers; Jonathan P Hannan
Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.
Journal of virology 2008;82(22):11217-27.
2008: Christoph Q Schmidt; Andrew Herbert; David Kavanagh; Carina Gandy; Christopher J Fenton; Bärbel S Blaum; Malcolm Lyon; Dusan Uhrín; Paul N Barlow
A new map of glycosaminoglycan and C3b binding sites on factor H.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2610-9.
2008: Henry G Hocking; Andrew Herbert; David Kavanagh; Dinesh C Soares; Viviana Ferreira; Michael K Pangburn; Dusan Uhrín; Paul N Barlow
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
The Journal of biological chemistry 2008;283(14):9475-87.
2008: Paul N Barlow; Gregory S Hageman; Susan M Lea
Complement factor H: using atomic resolution structure to illuminate disease mechanisms.
Advances in experimental medicine and biology 2008;632():117-42.
2008: C Q Schmidt; Andrew Herbert; H G Hocking; Dusan Uhrín; Paul N Barlow
Translational mini-review series on complement factor H: structural and functional correlations for factor H.
Clinical and experimental immunology 2008;151(1):14-24.
2007: Beverly E Prosser; Steven Johnson; Pietro Roversi; Andrew Herbert; Bärbel S Blaum; Jess Tyrrell; Thomas A Jowitt; Simon J Clark; Edward Tarelli; Dusan Uhrín; Paul N Barlow; Robert B Sim; Anthony J Day; Susan M Lea
Structural basis for complement factor H linked age-related macular degeneration.
The Journal of experimental medicine 2007;204(10):2277-83.
2007: Andrew Herbert; Jon A Deakin; Christoph Q Schmidt; Bärbel S Blaum; Claire Egan; Viviana Ferreira; Michael K Pangburn; Malcolm Lyon; Dusan Uhrín; Paul N Barlow
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
The Journal of biological chemistry 2007;282(26):18960-8.
2007: Lisa A Kuttner-Kondo; Dennis E Hourcade; Vernon E Anderson; Nasima Muqim; Lynne Mitchell; Dinesh C Soares; Paul N Barlow; M Edward Medof
Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases.
The Journal of biological chemistry 2007;282(25):18552-62.
2007: Barbara Royer-Zemmour; Dinesh C Soares; Paul N Barlow; Ronald E Bontrop; Patrice Roll; Andrée Robaglia-Schlupp; Antoine Blancher; Anthony Levasseur; Pierre Cau; Pierre Pontarotti; Pierre Szepetowski
Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.
BMC genetics 2007;8():72.
2006: Viviana Ferreira; Andrew Herbert; Henry G Hocking; Paul N Barlow; Michael K Pangburn
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6308-16.
2006: Andrew Herbert; Dusan Uhrín; Malcolm Lyon; Michael K Pangburn; Paul N Barlow
Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure.
The Journal of biological chemistry 2006;281(24):16512-20.
2006: Huw Thomas Jenkins; Linda Mark; Graeme Ball; Jenny Persson; Gunnar Lindahl; Dusan Uhrin; Anna Blom; Paul N Barlow
Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor.
The Journal of biological chemistry 2006;281(6):3690-7.
2006: Andrew Herbert; Dinesh C Soares; Michael K Pangburn; Paul N Barlow
Disease-associated sequence variations in factor H: a structural biology approach.
Advances in experimental medicine and biology 2006;586():313-27.
2005: Eve Brook; Andrew Herbert; Huw Thomas Jenkins; Dinesh C Soares; Paul N Barlow
Opportunities for new therapies based on the natural regulators of complement activation.
Annals of the New York Academy of Sciences 2005;1056():176-88.
2005: Dinesh C Soares; Dietlind L. Gerloff; Neil R Syme; Andrew F W Coulson; John Parkinson; Paul N Barlow
Large-scale modelling as a route to multiple surface comparisons of the CCP module family.
Protein engineering, design & selection : PEDS 2005;18(8):379-88.
2005: Stanislava Uhrinova; Dusan Uhrin; Helen Powers; Kathryn Watt; Daniella I Zheleva; Peter Fischer; Campbell McInnes; Paul N Barlow
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.
Journal of molecular biology 2005;350(3):587-98.
2005: Janice Bramham; Chuong-Thu Thai; Dinesh C Soares; Dusan Uhrín; Ronald T Ogata; Paul N Barlow
Functional insights from the structure of the multifunctional C345C domain of C5 of complement.
The Journal of biological chemistry 2005;280(11):10636-45.
2005: Krystyna Bromek; Donghan Lee; Richard Hauhart; Malgorzata Krych-Goldberg; John P Atkinson; Paul N Barlow; Konstantin Pervushin
Polychromatic selective population inversion for TROSY experiments with large proteins.
Journal of the American Chemical Society 2005;127(1):405-11.
2004: Stanislas Blein; Rachel Ginham; Dusan Uhrin; Brian O Smith; Dinesh C Soares; Stefvan Veltel; R A Jeffrey McIlhinney; John H White; Paul N Barlow
Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded.
The Journal of biological chemistry 2004;279(46):48292-306.
2004: Gordon Black; Michael Wenzler; Xuefeng Wang; Malgorzata Krych-Goldberg; John P Atkinson; Paul N Barlow
1H, 15N and 13C resonance assignments of complement control protein module pair 2-3 from the C4b-binding site of complement receptor type 1.
Journal of biomolecular NMR 2004;30(2):227-8.
2004: Kirstine L Anderson; Jason Billington; David Pettigrew; Ernesto Cota; Pete Simpson; Pietro Roversi; Ho An Chen; Petri Urvil; Laurence du Merle; Paul N Barlow; M Edward Medof; Richard A G Smith; Bogdan Nowicki; Chantal Le Bouguénec; Susan M Lea; Stephen Matthews
An atomic resolution model for assembly, architecture, and function of the Dr adhesins.
Molecular cell 2004;15(4):647-57.
2004: Janice Bramham; Mark Rance; Chuong-Thu Thai; Dusan Uhrín; Nuria Assa-Munt; Ronald T Ogata; Paul N Barlow
1H, 15N and 13C resonance assignments of the C345C domain of the complement component C5.
Journal of biomolecular NMR 2004;29(2):217-8.
2004: Joanne M O'Leary; Krystyna Bromek; Gordon M Black; Stanislava Uhrinova; Christian Schmitz; Xuefeng Wang; Malgorzata Krych; John P Atkinson; Dusan Uhrin; Paul N Barlow
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces.
Protein science : a publication of the Protein Society 2004;13(5):1238-50.
2003: Dmitriy Alexeev; Paul N Barlow; Stella M Bury; Jean-Damien Charrier; Alan Cooper; David Hadfield; Craig Jamieson; Sharon M Kelly; Robert Layfield; R John Mayer; Helen McSparron; Nicholas C Price; Robert Ramage; Lindsay Sawyer; Bernard A Starkmann; Dusan Uhrin; Jill Wilken; Douglas W Young
Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core.
Chembiochem : a European journal of chemical biology 2003;4(9):894-6.
2003: Stanislava Uhrinova; Feng Lin; Graeme Ball; Krystyna Bromek; Dusan Uhrin; M Edward Medof; Paul N Barlow
Solution structure of a functionally active fragment of decay-accelerating factor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4718-23.
2002: Andrew Herbert; J O'leary; Malgorzata Krych-Goldberg; John P Atkinson; Paul N Barlow
Three-dimensional structure and flexibility of proteins of the RCA family - a progress report.
Biochemical Society transactions 2002;30(Pt 6):990-6.
2002: Scott Smith; Gunasekaran Krishnasamy; Krishna H M Murthy; Alan Cooper; Krystyna Bromek; Paul N Barlow; Girish J Kotwal
Vaccinia virus complement control protein is monomeric, and retains structural and functional integrity after exposure to adverse conditions.
Biochimica et biophysica acta 2002;1598(1-2):55-64.
2002: Stanislava Uhrínová; Feng Lin; Du Usan Uhrín; M Edward Medof; Paul N Barlow
Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor.
Journal of biomolecular NMR 2002;23(2):167-8.
2002: Stanislava Uhrínová; Feng Lin; Dusan Uhrín; M Edward Medof; Paul N Barlow
Resonance assignments of the central complement control protein module pair of human decay accelerating factor.
Journal of biomolecular NMR 2002;23(2):167-8.
2002: Brian O Smith; Rosie L Mallin; Malgorzata Krych-Goldberg; Xuefeng Wang; Richard Hauhart; Krystyna Bromek; Dusan Uhrin; John P Atkinson; Paul N Barlow
Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.
Cell 2002;108(6):769-80.
2002: Janice Bramham; Julie L Hodgkinson; Brian O Smith; Dusan Uhrín; Paul N Barlow; Steven J Winder
Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin.
Structure (London, England : 1993) 2002;10(2):249-58.
2001: MD Kirkitadze; Paul N Barlow
Structure and flexibility of the multiple domain proteins that regulate complement activation.
Immunological reviews 2001;180():146-61.
2001: C E Henderson; Krystyna Bromek; Nicholas P Mullin; Brian O Smith; Dusan Uhrín; Paul N Barlow
Solution structure and dynamics of the central CCP module pair of a poxvirus complement control protein.
Journal of molecular biology 2001;307(1):323-39.
2001: Stanislava Uhrínová; Dusan Uhrín; Jacqueline Nairn; Nicholas C Price; Linda A Fothergill-Gilmore; Paul N Barlow
Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe.
Journal of molecular biology 2001;306(2):275-90.
2001: Andrew Free; R I Wakefield; Brian O Smith; David T F Dryden; Paul N Barlow; Adrian P Bird
DNA recognition by the methyl-CpG binding domain of MeCP2.
The Journal of biological chemistry 2001;276(5):3353-60.
2001: Janice Bramham; Brian O Smith; Dusan Uhrín; Paul N Barlow; Steven J Winder
1H, 15N and 13C resonance assignments of the N-terminal region of calponin.
Journal of biomolecular NMR 2001;19(2):189-90.
2001: Krishna H M Murthy; Scott Smith; Vannakambadi K Ganesh; Ken W Judge; Nicholas P Mullin; Paul N Barlow; C M Ogata; Girish J Kotwal
Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans.
Cell 2001;104(2):301-11.
2000: Jacqueline Nairn; D Duncan; N E Price; Sharon M Kelly; Linda A Fothergill-Gilmore; Stanislava Uhrinova; Paul N Barlow; Daniel J Rigden; Nicholas C Price
Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase. Elucidation of the roles of amino acids involved in substrate binding and catalysis.
European journal of biochemistry / FEBS 2000;267(24):7065-74.
2000: M Kathryn Liszewski; Marilyn Leung; W Cui; VB Subramanian; John Parkinson; Paul N Barlow; Marianne Manchester; John P Atkinson
Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46).
The Journal of biological chemistry 2000;275(48):37692-701.
2000: Dusan Uhrín; Janice Bramham; Steven J Winder; Paul N Barlow
Simultaneous CT-13C and VT-15N chemical shift labelling: application to 3D NOESY-CH3NH and 3D 13C,15N HSQC-NOESY-CH3NH.
Journal of biomolecular NMR 2000;18(3):253-9.
2000: Scott Smith; Nicholas P Mullin; John Parkinson; Sergei N Shchelkunov; Alexei Totmenin; Vladimir N Loparev; Ratchapin Srisatjaluk; David N Reynolds; Kristen L Keeling; David E Justus; Paul N Barlow; Girish J Kotwal
Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: a novel mechanism for evasion of host defense.
Journal of virology 2000;74(12):5659-66.
2000: Stanislava Uhrínová; M H Smith; G B Jameson; Dusan Uhrín; Lindsay Sawyer; Paul N Barlow
Structural changes accompanying pH-induced dissociation of the beta-lactoglobulin dimer.
Biochemistry 2000;39(13):3565-74.
2000: Dusan Uhrín; Stanislava Uhrínová; C Leadbeater; Jacqueline Nairn; Nicholas C Price; Paul N Barlow
3D HCCH(3)-TOCSY for resonance assignment of methyl-containing side chains in (13)C-labeled proteins.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2000;142(2):288-93.
1999: MD Kirkitadze; C Henderson; Nicholas C Price; Sharon M Kelly; Nicholas P Mullin; John Parkinson; David T F Dryden; Paul N Barlow
Central modules of the vaccinia virus complement control protein are not in extensive contact.
The Biochemical journal 1999;344 Pt 1():167-75.
1999: MD Kirkitadze; David T F Dryden; Sharon M Kelly; Nicholas C Price; Xuefeng Wang; Malgorzata Krych; John P Atkinson; Paul N Barlow
Co-operativity between modules within a C3b-binding site of complement receptor type 1.
FEBS letters 1999;459(1):133-8.
1999: R I Wakefield; Brian O Smith; Xinsheng Nan; Andrew Free; A Soteriou; Dusan Uhrin; Adrian P Bird; Paul N Barlow
The solution structure of the domain from MeCP2 that binds to methylated DNA.
Journal of molecular biology 1999;291(5):1055-65.
1999: MD Kirkitadze; Malgorzata Krych; Dusan Uhrin; David T F Dryden; Brian O Smith; Alan Cooper; Xuefeng Wang; Richard Hauhart; John P Atkinson; Paul N Barlow
Independently melting modules and highly structured intermodular junctions within complement receptor type 1.
Biochemistry 1999;38(22):7019-31.
1998: MD Kirkitadze; Paul N Barlow; Nicholas C Price; Sharon M Kelly; C J Boutell; Frazer J Rixon; D A McClelland
The herpes simplex virus triplex protein, VP23, exists as a molten globule.
Journal of virology 1998;72(12):10066-72.
1998: H Denton; M Smith; Holger Husi; Dusan Uhrin; Paul N Barlow; Carl A Batt; Lindsay Sawyer
Isotopically labeled bovine beta-lactoglobulin for NMR studies expressed in Pichia pastoris.
Protein expression and purification 1998;14(1):97-103.
1998: Stanislava Uhrínová; Dusan Uhrín; H Denton; M Smith; Lindsay Sawyer; Paul N Barlow
Complete assignment of 1H, 13C and 15N chemical shifts for bovine beta-lactoglobulin: secondary structure and topology of the native state is retained in a partially unfolded form.
Journal of biomolecular NMR 1998;12(1):89-107.
1998: Dusan Uhrín; Gyula Batta; V J Hruby; Paul N Barlow; Katalin E Kövér
Sensitivity- and gradient-enhanced hetero (omega1) half-filtered TOCSY experiment for measuring long-range heteronuclear coupling constants.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1998;130(2):155-61.
1997: Stanislava Uhrínová; Dusan Uhrín; Jacqueline Nairn; Nicholas C Price; Linda A Fothergill-Gilmore; Paul N Barlow
Backbone assignment of double labelled 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe.
Journal of biomolecular NMR 1997;10(3):309-10.
1997: A P Wiles; G Shaw; J Bright; A Perczel; I D Campbell; Paul N Barlow
NMR studies of a viral protein that mimics the regulators of complement activation.
Journal of molecular biology 1997;272(2):253-65.
1994: Hans Hoppe; Paul N Barlow; Kenneth B M Reid
A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation.
FEBS letters 1994;344(2-3):191-5.
1994: Paul N Barlow; B Luisi; A Milner; M Elliott; R Everett
Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger.
Journal of molecular biology 1994;237(2):201-11.
1994: Paul N Barlow; Iain D Campbell
Strategy for studying modular proteins: application to complement modules.
Methods in enzymology 1994;239():464-85.
1993: Anthony J Day; Paul N Barlow; Alexander Steinkasserer; Iain D Campbell; Robert B Sim
Progress in determining module structures in C1r and C1s.
Behring Institute Mitteilungen 1993;(93):31-40.
1993: Paul N Barlow; Alexander Steinkasserer; David G Norman; B Kieffer; A P Wiles; Robert B Sim; Iain D Campbell
Solution structure of a pair of complement modules by nuclear magnetic resonance.
Journal of molecular biology 1993;232(1):268-84.
1992: Alexander Steinkasserer; Paul N Barlow; Antony C Willis; Z Kertesz; Iain D Campbell; Robert B Sim; David G Norman
Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I.
FEBS letters 1992;313(2):193-7.
1992: Paul N Barlow; David G Norman; Alexander Steinkasserer; T J Horne; J Pearce; Paul C Driscoll; Robert B Sim; Iain D Campbell
Solution structure of the fifth repeat of factor H: a second example of the complement control protein module.
Biochemistry 1992;31(14):3626-34.
1991: David G Norman; Paul N Barlow; M Baron; Anthony J Day; Robert B Sim; Iain D Campbell
Three-dimensional structure of a complement control protein module in solution.
Journal of molecular biology 1991;219(4):717-25.
1991: Paul N Barlow; M Baron; David G Norman; Anthony J Day; Antony C Willis; Robert B Sim; Iain D Campbell
Secondary structure of a complement control protein module by two-dimensional 1H NMR.
Biochemistry 1991;30(4):997-1004.
1989: Paul N Barlow; R J Appleyard; J O Wilson; J N Evans
Direct observation of the enzyme-intermediate complex of 5-enolpyruvylshikimate-3-phosphate synthase by 13C NMR spectroscopy.
Biochemistry 1989;28(20):7985-91.