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Xian Lin

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Xian Lin; Guoxiang Liu; Cai-Xia Long; David Lovinger; Jing Luo; Yolanda Mateo; Loukia Parisiadou; Carmelo Sgobio; Hoon Shim; Patricia H Sullivan; Lixin Sun; Ling-Gang Wu; Jia Yu; Jinhui Ding; David S Goldstein; Xing-Long Gu; Huaibin Cai
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.
Xian Lin; Loukia Parisiadou; Xing-Long Gu; Lizhen Wang; Hoon Shim; Lixin Sun; Chengsong Xie; Cai-Xia Long; Wan-Jou Yang; Jinhui Ding; Zsu Zsu Chen; Paul E Gallant; Jung-Hwa Tao-Cheng; Gay Rudow; Juan C Troncoso; Zhihua Liu; Zheng Li; Huaibin Cai
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Loukia Parisiadou; Chengsong Xie; Hyun Jin Cho; Xian Lin; Xing-Long Gu; Cai-Xia Long; Evy Lobbestael; Veerle Baekelandt; Jean-Marc Taymans; Lixin Sun; Huaibin Cai
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

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All Publications

2012: Xian Lin; Guoxiang Liu; Cai-Xia Long; David Lovinger; Jing Luo; Yolanda Mateo; Loukia Parisiadou; Carmelo Sgobio; Hoon Shim; Patricia H Sullivan; Lixin Sun; Ling-Gang Wu; Jia Yu; Jinhui Ding; David S Goldstein; Xing-Long Gu; Huaibin Cai
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(27):9248-64.
2009: Xian Lin; Loukia Parisiadou; Xing-Long Gu; Lizhen Wang; Hoon Shim; Lixin Sun; Chengsong Xie; Cai-Xia Long; Wan-Jou Yang; Jinhui Ding; Zsu Zsu Chen; Paul E Gallant; Jung-Hwa Tao-Cheng; Gay Rudow; Juan C Troncoso; Zhihua Liu; Zheng Li; Huaibin Cai
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Neuron 2009;64(6):807-27.
2009: Loukia Parisiadou; Chengsong Xie; Hyun Jin Cho; Xian Lin; Xing-Long Gu; Cai-Xia Long; Evy Lobbestael; Veerle Baekelandt; Jean-Marc Taymans; Lixin Sun; Huaibin Cai
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(44):13971-80.
2008: Lizhen Wang; Chengsong Xie; Elisa Greggio; Loukia Parisiadou; Hoon Shim; Lixin Sun; Jayanth Chandran; Xian Lin; Chen Lai; Wan-Jou Yang; Darren J Moore; Ted M Dawson; Valina Dawson; Gabriela Chiosis; Mark Cookson; Huaibin Cai
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(13):3384-91.
2008: Jayanth S Chandran; Xian Lin; Agustin Zapata; Ahmet Höke; Mika Shimoji; Shonagh O'Leary Moore; matthew galloway; Fiona M Laird; Philip C Wong; Donald L Price; Kathleen R Bailey; Jacqueline N Crawley; Toni Shippenberg; Huaibin Cai
Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.
Neurobiology of disease 2008;29(3):505-14.
2008: Huaibin Cai; Hoon Shim; Chen Lai; Chengsong Xie; Xian Lin; Wan Jou Yang; Jayanth Chandran
ALS2/alsin knockout mice and motor neuron diseases.
Neuro-degenerative diseases 2008;5(6):359-66.
2007: Chen Lai; Xian Lin; Jayanth Chandran; Hoon Shim; Wan-Jou Yang; Huaibin Cai
The G59S mutation in p150(glued) causes dysfunction of dynactin in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(51):13982-90.
2007: Xian Lin; Hoon Shim; Huaibin Cai
Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.
Neurobiology of aging 2007;28(10):1628-30.
2007: Joyce van de Leemput; Jayanth Chandran; Melanie A Knight; Lynne A Holtzclaw; Sonja Scholz; Mark Cookson; Henry Houlden; Katrina Gwinn-Hardy; Hon-Chung Fung; Xian Lin; Dena Hernandez; Javier Simon-Sanchez; Nicholas W Wood; Paola Giunti; Ian Rafferty; John Hardy; Elsdon Storey; R J McKinlay Gardner; Susan M Forrest; Elizabeth M C Fisher; James T Russell; Huaibin Cai; Andrew Singleton
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.
PLoS genetics 2007;3(6):e108.
2006: Chen Lai; Chengsong Xie; Stefanie G McCormack; Hsueh-Cheng Chiang; Marta K Michalak; Xian Lin; Jayanth Chandran; Hoon Shim; Mika Shimoji; Mark Cookson; Richard Huganir; Jeffrey rothstein; Donald L Price; Philip C Wong; Lee J Martin; J Julius Zhu; Huaibin Cai
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(45):11798-806.
2005: Huaibin Cai; Xian Lin; Chengsong Xie; Fiona M Laird; Chen Lai; Hongjin Wen; Hsueh-Cheng Chiang; Hoon Shim; Mohamed H Farah; Ahmet Hoke; Donald L Price; Philip C Wong
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(33):7567-74.