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David Linden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Anatomy

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Electrophysiology

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Co-Publications
Name
7
Huganir, Richard
7
Routtenberg, Aryeh
6
Hansel, Christian
6
Worley, Paul
5
Aizenman, Carlos
5
Connor, John
5
Shen, Ying
4
Parent, Angèle
3
SHIN, JUNG
3
Zhang, Wei
3
Steinberg, Jordan
3
De Zeeuw, Chris
3
Kim, Sang Jeong
2
Ginty, David
2
Lonart, György

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Publications

TOP 3
Kim Yu Shin; Shin Jung Hoon; Hall F Scott; Linden David J
Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.
Cohen Kadosh Roi; Cohen Kadosh Kathrin; Henik Avishai; Linden David E J
Processing conflicting information: facilitation, interference, and functional connectivity.
Linden David J
Warm, fuzzy feeling.

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All Publications

2009: Kim Yu Shin; Shin Jung Hoon; Hall F Scott; Linden David J
Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(26):8530-8.
2008: Cohen Kadosh Roi; Cohen Kadosh Kathrin; Henik Avishai; Linden David E J
Processing conflicting information: facilitation, interference, and functional connectivity.
Neuropsychologia 2008;46(12):2872-9.
2008: Linden David J
Warm, fuzzy feeling.
Journal of neurophysiology 2008;100(1):1.
2008: Park Sungjin; Park Joo Min; Kim Sangmok; Kim Jin-Ah; Shepherd Jason D; Smith-Hicks Constance L; Chowdhury Shoaib; Kaufmann Walter; Kuhl Dietmar; Ryazanov Alexey G; Huganir Richard L; Linden David J; Worley Paul F
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.
Neuron 2008;59(1):70-83.
2008: Takamiya Kogo; Mao Lifang; Huganir Richard L; Linden David J
The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(22):5752-5.
2008: Kim Sang Jeong; Jin Yunju; Kim Jun; Shin Jung Hoon; Worley Paul F; Linden David J
Transient upregulation of postsynaptic IP3-gated Ca release underlies short-term potentiation of metabotropic glutamate receptor 1 signaling in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(17):4350-5.
2008: Cho Richard W; Park Joo Min; Wolff Steffen B E; Xu Desheng; Hopf Carsten; Kim Jin-Ah; Reddy Radhika C; Petralia Ronald S; Perin Mark S; Linden David J; Worley Paul F
mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.
Neuron 2008;57(6):858-71.
2008: Wibral Michael; Turi Georg; Linden David E J; Kaiser Jochen; Bledowski Christoph
Decomposition of working memory-related scalp ERPs: crossvalidation of fMRI-constrained source analysis and ICA.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology 2008;67(3):200-11.
2008: Shin Jung Hoon; Kim Yu Shin; Linden David J
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):746-50.
2008: Sireteanu Ruxandra; Oertel Viola; Mohr Harald; Linden David; Singer Wolf
Graphical illustration and functional neuroimaging of visual hallucinations during prolonged blindfolding: a comparison to visual imagery.
Perception 2008;37(12):1805-21.
2007: Kim Sang Jeong; Linden David J
Ubiquitous plasticity and memory storage.
Neuron 2007;56(4):582-92.
2007: Nishiyama Hiroshi; Fukaya Masahiro; Watanabe Masahiko; Linden David J
Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum.
Neuron 2007;56(3):472-87.
2007: Jin Yunju; Kim Sang Jeong; Kim Jun; Worley Paul F; Linden David J
Long-term depression of mGluR1 signaling.
Neuron 2007;55(2):277-87.
2007: Nishiyama Hiroshi; Linden David J
Pure spillover transmission between neurons.
Nature neuroscience 2007;10(6):675-7.
2007: Sdrulla Andrei D; Linden David J
Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells.
Nature neuroscience 2007;10(5):546-8.
2007: Shen Ying; Kishimoto Koji; Linden David J; Sapirstein Adam
Cytosolic phospholipase A(2) alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):6078-83.
2006: Wagner Karen Dineen; Kowatch Robert A; Emslie Graham J; Findling Robert L; Wilens Timothy E; McCague Kevin; D'Souza Joseph; Wamil Artur; Lehman Robert B; Berv Douglas; Linden David
A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents.
The American journal of psychiatry 2006;163(7):1179-86.
2006: Zhang Wei; Linden David J
Long-term depression at the mossy fiber-deep cerebellar nucleus synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(26):6935-44.
2006: Steinberg Jordan P; Takamiya Kogo; Shen Ying; Xia Jun; Rubio Maria E; Yu Sandy; Jin Wenying; Thomas Gareth M; Linden David J; Huganir Richard L
Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression.
Neuron 2006;49(6):845-60.
2006: Sdrulla Andrei D; Linden David J
Dynamic imaging of cerebellar Purkinje cells reveals a population of filopodia which cross-link dendrites during early postnatal development.
Cerebellum (London, England) 2006;5(2):105-15.
2005: Shin Jung Hoon; Linden David J
An NMDA receptor/nitric oxide cascade is involved in cerebellar LTD but is not localized to the parallel fiber terminal.
Journal of neurophysiology 2005;94(6):4281-9.
2005: Shen Ying; Linden David J
Long-term potentiation of neuronal glutamate transporters.
Neuron 2005;46(5):715-22.
2005: Ramanan Narendrakumar; Shen Ying; Sarsfield Sarah; Lemberger Thomas; Schütz Günther; Linden David J; Ginty David D
SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability.
Nature neuroscience 2005;8(6):759-67.
2004: Steinberg Jordan P; Huganir Richard L; Linden David J
N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18212-6.
2004: Simsek-Duran Fatma; Linden David J; Lonart György
Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum.
Nature neuroscience 2004;7(12):1296-8.
2004: Zhang Wei; Shin Jung Hoon; Linden David J
Persistent changes in the intrinsic excitability of rat deep cerebellar nuclear neurones induced by EPSP or IPSP bursts.
The Journal of physiology 2004;561(Pt 3):703-19.
2004: Leitges Michael; Kovac Judit; Plomann Markus; Linden David J
A unique PDZ ligand in PKCalpha confers induction of cerebellar long-term synaptic depression.
Neuron 2004;44(4):585-94.
2004: Nishiyama Hiroshi; Linden David J
Differential maturation of climbing fiber innervation in cerebellar vermis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(16):3926-32.
2003: Kim Sang Jeong; Kim Yu Shin; Yuan Joseph P; Petralia Ronald S; Worley Paul F; Linden David J
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.
Nature 2003;426(6964):285-91.
2003: Zhang Wei; Linden David J
The other side of the engram: experience-driven changes in neuronal intrinsic excitability.
Nature reviews. Neuroscience 2003;4(11):885-900.
2003: Lonart György; Schoch Susanne; Kaeser Pascal S; Larkin C Jenny; Südhof Thomas C; Linden David J
Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses.
Cell 2003;115(1):49-60.
2003: Linden David J
Neuroscience. From molecules to memory in the cerebellum.
Science (New York, N.Y.) 2003;301(5640):1682-5.
2003: Chung Hee Jung; Steinberg Jordan P; Huganir Richard L; Linden David J
Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression.
Science (New York, N.Y.) 2003;300(5626):1751-5.
2003: Aizenman Carlos D; Huang Eric J; Linden David J
Morphological correlates of intrinsic electrical excitability in neurons of the deep cerebellar nuclei.
Journal of neurophysiology 2003;89(4):1738-47.
2003: Coesmans Michiel; Smitt Peter A Sillevis; Linden David J; Shigemoto Ryuichi; Hirano Tomoo; Yamakawa Yoshinori; van Alphen Adriaan M; Luo Chongde; van der Geest Josef N; Kros Johan M; Gaillard Carlo A; Frens Maarten A; de Zeeuw Chris I
Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies.
Annals of neurology 2003;53(3):325-36.
2003: Weber John T; De Zeeuw Chris I; Linden David J; Hansel Christian
Long-term depression of climbing fiber-evoked calcium transients in Purkinje cell dendrites.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2878-83.
2002: Eto Masumi; Bock Roland; Brautigan David L; Linden David J
Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor.
Neuron 2002;36(6):1145-58.
2002: Shen Ying; Hansel Christian; Linden David J
Glutamate release during LTD at cerebellar climbing fiber-Purkinje cell synapses.
Nature neuroscience 2002;5(8):725-6.
2001: Linden D J
The expression of cerebellar LTD in culture is not associated with changes in AMPA-receptor kinetics, agonist affinity, or unitary conductance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14066-71.
2001: Hansel C; Linden D J; D'Angelo E
Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum.
Nature neuroscience 2001;4(5):467-75.
2000: Xia J; Chung H J; Wihler C; Huganir R L; Linden D J
Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins.
Neuron 2000;28(2):499-510.
2000: Ho N; Liauw J A; Blaeser F; Wei F; Hanissian S; Muglia L M; Wozniak D F; Nardi A; Arvin K L; Holtzman D M; Linden D J; Zhuo M; Muglia L J; Chatila T A
Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6459-72.
2000: Hansel C; Linden D J
Long-term depression of the cerebellar climbing fiber--Purkinje neuron synapse.
Neuron 2000;26(2):473-82.
2000: Mothet J P; Parent A T; Wolosker H; Brady R O; Linden D J; Ferris C D; Rogawski M A; Snyder S H
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4926-31.
2000: Wang Y T; Linden D J
Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis.
Neuron 2000;25(3):635-47.
2000: Takahashi K A; Linden D J
Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells.
Journal of neurophysiology 2000;83(3):1167-80.
2000: Aizenman C D; Linden D J
Rapid, synaptically driven increases in the intrinsic excitability of cerebellar deep nuclear neurons.
Nature neuroscience 2000;3(2):109-11.
2000: Aizenman C D; Huang E J; Manis P B; Linden D J
Use-dependent changes in synaptic strength at the Purkinje cell to deep nuclear synapse.
Progress in brain research 2000;124():257-73.
1999: Linden D J; Ahn S
Activation of presynaptic cAMP-dependent protein kinase is required for induction of cerebellar long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(23):10221-7.
1999: Aizenman C D; Linden D J
Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum.
Journal of neurophysiology 1999;82(4):1697-709.
1999: Ahn S; Ginty D D; Linden D J
A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB.
Neuron 1999;23(3):559-68.
1999: Linden D J
The return of the spike: postsynaptic action potentials and the induction of LTP and LTD.
Neuron 1999;22(4):661-6.
1999: Parent A; Linden D J; Sisodia S S; Borchelt D R
Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
Neurobiology of disease 1999;6(1):56-62.
1998: Narasimhan K; Pessah I N; Linden D J
Inositol-1,4,5-trisphosphate receptor-mediated Ca mobilization is not required for cerebellar long-term depression in reduced preparations.
Journal of neurophysiology 1998;80(6):2963-74.
1998: Aizenman C D; Manis P B; Linden D J
Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse.
Neuron 1998;21(4):827-35.
1998: Tu J C; Xiao B; Yuan J P; Lanahan A A; Leoffert K; Li M; Linden D J; Worley P F
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.
Neuron 1998;21(4):717-26.
1998: Storm D R; Hansel C; Hacker B; Parent A; Linden D J
Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice.
Neuron 1998;20(6):1199-210.
1998: Parent A; Schrader K; Munger S D; Reed R R; Linden D J; Ronnett G V
Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse.
Journal of neurophysiology 1998;79(6):3295-301.
1998: Linden D J
Synaptically evoked glutamate transport currents may be used to detect the expression of long-term potentiation in cerebellar culture.
Journal of neurophysiology 1998;79(6):3151-6.
1998: De Zeeuw C I; Hansel C; Bian F; Koekkoek S K; van Alphen A M; Linden D J; Oberdick J
Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex.
Neuron 1998;20(3):495-508.
1997: Zuo J; De Jager P L; Takahashi K A; Jiang W; Linden D J; Heintz N
Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene.
Nature 1997;388(6644):769-73.
1997: Linden D J
Long-term potentiation of glial synaptic currents in cerebellar culture.
Neuron 1997;18(6):983-94.
1996: Jeromin A; Huganir R L; Linden D J
Suppression of the glutamate receptor delta 2 subunit produces a specific impairment in cerebellar long-term depression.
Journal of neurophysiology 1996;76(5):3578-83.
1996: Linden D J
A protein synthesis-dependent late phase of cerebellar long-term depression.
Neuron 1996;17(3):483-90.
1996: Narasimhan K; Linden D J
Defining a minimal computational unit for cerebellar long-term depression.
Neuron 1996;17(2):333-41.
1996: Kaplin A I; Snyder S H; Linden D J
Reduced nicotinamide adenine dinucleotide-selective stimulation of inositol 1,4,5-trisphosphate receptors mediates hypoxic mobilization of calcium.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(6):2002-11.
1995: Linden D J
Phospholipase A2 controls the induction of short-term versus long-term depression in the cerebellar Purkinje neuron in culture.
Neuron 1995;15(6):1393-401.
1995: Linden D J; Dawson T M; Dawson V L
An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(7 Pt 2):5098-105.
1995: Linden D J; Connor J A
Long-term synaptic depression.
Annual review of neuroscience 1995;18():319-57.
1994: Linden D J
Input-specific induction of cerebellar long-term depression does not require presynaptic alteration.
Learning & memory (Cold Spring Harbor, N.Y.) 1994;1(2):121-8.
1994: Linden D J; Smeyne M; Connor J A
Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
Journal of neurophysiology 1994;71(5):1992-8.
1994: Linden D J
Long-term synaptic depression in the mammalian brain.
Neuron 1994;12(3):457-72.
1993: Linden D J; Narasimhan K; Gurfel D
Protoporphyrins modulate voltage-gated Ca current in AtT-20 pituitary cells.
Journal of neurophysiology 1993;70(6):2673-7.
1993: Linden D J; Smeyne M; Connor J A
Induction of cerebellar long-term depression in culture requires postsynaptic action of sodium ions.
Neuron 1993;11(6):1093-100.
1993: Linden D J; Connor J A
Cellular mechanisms of long-term depression in the cerebellum.
Current opinion in neurobiology 1993;3(3):401-6.
1992: Linden D J; Smeyne M; Sun S C; Connor J A
An electrophysiological correlate of protein kinase C isozyme distribution in cultured cerebellar neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(9):3601-8.
1991: Linden D J; Connor J A
Participation of postsynaptic PKC in cerebellar long-term depression in culture.
Science (New York, N.Y.) 1991;254(5038):1656-9.
1991: Linden D J; Dickinson M H; Smeyne M; Connor J A
A long-term depression of AMPA currents in cultured cerebellar Purkinje neurons.
Neuron 1991;7(1):81-9.
1989: Linden D J; Routtenberg A
cis-Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells.
The Journal of physiology 1989;419():95-119.
1989: Nelson R B; Linden D J; Routtenberg A
Phosphoproteins localized to presynaptic terminal linked to persistence of long-term potentiation (LTP): quantitative analysis of two-dimensional gels.
Brain research 1989;497(1):30-42.
1989: Linden D J; Routtenberg A
The role of protein kinase C in long-term potentiation: a testable model.
Brain research. Brain research reviews 1989;14(3):279-96.
1989: Nelson R B; Linden D J; Hyman C; Pfenninger K H; Routtenberg A
The two major phosphoproteins in growth cones are probably identical to two protein kinase C substrates correlated with persistence of long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(2):381-9.
1988: Linden D J; Wong K L; Sheu F S; Routtenberg A
NMDA receptor blockade prevents the increase in protein kinase C substrate (protein F1) phosphorylation produced by long-term potentiation.
Brain research 1988;458(1):142-6.
1988: Barnes C A; Mizumori S J; Lovinger D M; Sheu F S; Murakami K; Chan S Y; Linden D J; Nelson R B; Routtenberg A
Selective decline in protein F1 phosphorylation in hippocampus of senescent rats.
Neurobiology of aging 1988;9(4):393-8.
1987: Linden D J; Sheu F S; Murakami K; Routtenberg A
Enhancement of long-term potentiation by cis-unsaturated fatty acid: relation to protein kinase C and phospholipase A2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(11):3783-92.
1986: Linden D J; Murakami K; Routtenberg A
A newly discovered protein kinase C activator (oleic acid) enhances long-term potentiation in the intact hippocampus.
Brain research 1986;379(2):358-63.
1986: Routtenberg A; Colley P; Linden D; Lovinger D; Murakami K; Sheu F S
Phorbol ester promotes growth of synaptic plasticity.
Brain research 1986;378(2):374-8.
1986: Linden D; Martinez J L
Leu-enkephalin impairs memory of an appetitive maze response in mice.
Behavioral neuroscience 1986;100(1):33-8.
1986: Akers R F; Lovinger D M; Colley P A; Linden D J; Routtenberg A
Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.
Science (New York, N.Y.) 1986;231(4738):587-9.

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