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Stig Linder

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Jenny Felth; Mårten Fryknäs; Joachim Gullbo; Caroline Haglund; Rolf Larsson; Karolina Lesiak-Mieczkowska; Stig Linder; Lars Bohlin; Padraig D'Arcy; Linda Rickardson
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.
Qing Cheng; Jonas Grafström; Katarina Johansson; Stig Linder; Li Lu; Margaretha Olofsson; Erik Samén; Hanna-Stina Ahlzén; Elias S J Arnér; Jan-Olov Thorell; Sharon Stone-Elander
Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death.
Malin Jarvius; Pädraig D'Arcy; Mårten Fryknäs; Joachim Gullbo; Caroline Haglund; Stig Linder; Peter Nygren; Linda Rickardson; Chao Sun; Rolf Larsson
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.

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2013: Jenny Felth; Mårten Fryknäs; Joachim Gullbo; Caroline Haglund; Rolf Larsson; Karolina Lesiak-Mieczkowska; Stig Linder; Lars Bohlin; Padraig D'Arcy; Linda Rickardson
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.
Investigational new drugs 2013;31(3):587-98.
2013: Qing Cheng; Jonas Grafström; Katarina Johansson; Stig Linder; Li Lu; Margaretha Olofsson; Erik Samén; Hanna-Stina Ahlzén; Elias S J Arnér; Jan-Olov Thorell; Sharon Stone-Elander
Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death.
Biochimica et biophysica acta 2013;1830(3):2562-73.
2013: Malin Jarvius; Pädraig D'Arcy; Mårten Fryknäs; Joachim Gullbo; Caroline Haglund; Stig Linder; Peter Nygren; Linda Rickardson; Chao Sun; Rolf Larsson
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.
Biochemical and biophysical research communications 2013;431(2):117-23.
2012: Pádraig D'Arcy; Stig Linder
Proteasome deubiquitinases as novel targets for cancer therapy.
The international journal of biochemistry & cell biology 2012;44(11):1729-38.
2012: Emma Hernlund; Rolf Larsson; Karolina Lesiak-Mieczkowska; Slavica Brnjic; Padraig D'Arcy; Walid Fayad; Mårten Fryknäs; Margaretha Olofsson; Vivien Schmidt; Tobias Sjöblom; Xiaonan Zhang; Angelo De Milito; Stig Linder
The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.
European journal of cancer (Oxford, England : 1990) 2012;48(3):396-406.
2012: Qing Cheng; Jonas Grafström; Katarina Johansson; Stig Linder; Li Lu; Margaretha Olofsson; Erik Samén; Sharon Stone-Elander; Jan-Olov Thorell; Hanna-Stina Ahlzén; Elias Arnér
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.
PloS one 2012;7(8):e42151.
2011: Pádraig D'Arcy; Michelandrea De Cesare; Mårten Fryknäs; Moustapha Hassan; Rolf Larsson; Kristina Lindsten; Margaretha Olofsson; Paola Perego; Behnam Sadeghi; Slavica Brnjic; Stig Linder
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
Nature medicine 2011;17(12):1636-40.
2011: Saadia Hassan; Rolf Larsson; Daniel Laryea; Stig Linder; Haile Mahteme; Walid Fayad; Jenny Felth; Mårten Fryknäs; Bengt Glimelius; Wilhelm Graf; Joachim Gullbo; Lars Påhlman; Linda Rickardson; Peter Nygren
Novel activity of acriflavine against colorectal cancer tumor cells.
Cancer science 2011;102(12):2206-13.
2011: Stig Linder
Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) - the need for correct terminology.
Journal of hepatology 2011;55(6):1467.
2011: Walid Fayad; Padraig D'Arcy; Caroline Haglund; Rolf Larsson; Stig Linder; Margaretha Olofsson; Linda Rickardson; Mårten Fryknäs
Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties.
Chemical biology & drug design 2011;78(4):547-57.
2011: Luigi De Petris; Eva Brandén; Richard Herrmann; Betzabe Chavez Sanchez; Hirsh Koyi; Barbro Linderholm; Rolf Lewensohn; Stig Linder; Janne Lehtiö
Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer.
European journal of cancer (Oxford, England : 1990) 2011;47(1):131-7.
2010: Slavica Brnjic; Margaretha Olofsson; Aleksandra Mandic Havelka; Stig Linder
Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis.
Molecular bioSystems 2010;6(5):767-74.
2010: Stig Linder; Maria Hägg Olofsson; Richard Herrmann; Engin Ulukaya
Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.
Expert review of molecular diagnostics 2010;10(3):353-9.
2009: Walid Fayad; Slavica Brnjic; Daniel Berglind; Susanna Blixt; Maria C Shoshan; Maria Berndtsson; Margaretha Olofsson; Stig Linder
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.
International journal of cancer. Journal international du cancer 2009;125(10):2450-5.
2009: Emma Hernlund; Ozgur Kutuk; Huveyda Basaga; Stig Linder; Theocharis Panaretakis; Maria Shoshan
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation.
Free radical biology & medicine 2009;46(12):1607-13.
2009: Maria Berndtsson; Emma Hernlund; Maria C Shoshan; Stig Linder
Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.
Journal of chemical biology 2009;2(2):81-7.
2009: Maria Berndtsson; Melanie Beaujouin; Linda Rickardson; Aleksandra Mandic Havelka; Rolf Larsson; Jacob Westman; Emmanuelle Liaudet-Coopman; Stig Linder
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.
International journal of cancer. Journal international du cancer 2009;124(6):1463-9.
2009: Stig Linder; Ayodele Alaiya
Serum efficacy biomarkers for oncology.
Biomarkers in medicine 2009;3(1):47-54.
2009: Walid Fayad; Mårten Fryknäs; Slavica Brnjic; Margaretha Olofsson; Rolf Larsson; Stig Linder
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
PloS one 2009;4(10):e7238.
2009: Margaretha Olofsson; Jeffrey L Cummings; Jeff Cummings; S Brnjic; R Herrmann; Maria Berndtsson; C Hodgkinson; E Dean; R Odedra; R W Wilkinson; K E Mundt; M Busk; C Dive; Stig Linder
Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.
Cancer biomarkers : section A of Disease markers 2009;5(3):117-25.
2008: Emma Hernlund; Linda Strandberg Ihrlund; Omar Khan; Yildiz Ozlem Ates; Stig Linder; Theocharis Panaretakis; Maria C Shoshan
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.
International journal of cancer. Journal international du cancer 2008;123(2):476-83.
2008: Maria C Shoshan; Stig Linder
Target specificity and off-target effects as determinants of cancer drug efficacy.
Expert opinion on drug metabolism & toxicology 2008;4(3):273-80.
2008: Takayuki Ueno; Göran Elmberger; Timothy E Weaver; Masakazu Toi; Stig Linder
The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity.
Laboratory investigation; a journal of technical methods and pathology 2008;88(3):256-63.
2008: Maria Hägg Olofsson; Aleksandra Mandic Havelka; Slavica Brnjic; Maria C Shoshan; Stig Linder
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.
BMC chemical biology 2008;8():2.
2008: Richard Herrmann; Walid Fayad; Stephan Schwarz; Maria Berndtsson; Stig Linder
Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids.
Journal of biomolecular screening 2008;13(1):1-8.
2007: Aleksandra Mandic Havelka; Maria Berndtsson; Maria Hägg Olofsson; Maria C Shoshan; Stig Linder
Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?
Mini reviews in medicinal chemistry 2007;7(10):1035-9.
2007: Maria Hägg Olofsson; Takayuki Ueno; Yang Pan; Ren Xu; Feng Cai; Heiko van der Kuip; Thomas E Muerdter; Maike Sonnenberg; Walter Aulitzky; Stephan Schwarz; Elina Andersson; Maria C Shoshan; Aleksandra Mandic Havelka; Masakazu Toi; Stig Linder
Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3198-206.
2007: Sofia Bengtsson; Morten Krogh; Cristina Al-Khalili Szigyarto; Mathias Uhlen; Kjell Schedvins; Claes Silfverswärd; Stig Linder; Gert Auer; Ayodele A Alaiya; Peter James
Large-scale proteomics analysis of human ovarian cancer for biomarkers.
Journal of proteome research 2007;6(4):1440-50.
2007: Stig Linder
Cytokeratin markers come of age.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2007;28(4):189-95.
2007: Maria Berndtsson; Maria Hägg; Theocharis Panaretakis; Aleksandra Mandic Havelka; Maria C Shoshan; Stig Linder
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.
International journal of cancer. Journal international du cancer 2007;120(1):175-80.
2006: Maria C Shoshan; Frank Neumann; Associate Professor Principal Investigator Aleksandra Mandic Havelka; Stig Linder
Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.
Expert opinion on drug discovery 2006;1(6):585-94.
2006: G Kramer; S Schwarz; Maria Hägg; A Mandic Havelka; Stig Linder
Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles.
British journal of cancer 2006;94(11):1592-8.
2006: Linda Strandberg Ihrlund; Emma Hernlund; Kristina Viktorsson; Theocharis Panaretakis; Gabor Barna; Kanaga Sabapathy; Stig Linder; Maria C Shoshan
Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.
Experimental cell research 2006;312(9):1581-9.
2006: Stig Linder; Maria C Shoshan
Is translational research compatible with preclinical publication strategies?
Radiation oncology (London, England) 2006;1():4.
2005: Ayodele A Alaiya; Mai Al-Mohanna; Stig Linder
Clinical cancer proteomics: promises and pitfalls.
Journal of proteome research 2005;4(4):1213-22.
2005: Maria Berndtsson; Yoshiyuki Konishi; Azad Bonni; Maria Hägg; Maria C Shoshan; Stig Linder; Aleksandra Mandic Havelka
Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis.
FEBS letters 2005;579(14):3090-4.
2005: Hamdiye Erdal; Maria Berndtsson; Juan Castro; Ulf Brunk; Maria C Shoshan; Stig Linder
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):192-7.
2004: Stig Linder; Aleksandra Mandic Havelka; Takayuki Ueno; Maria C Shoshan
Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.
Cancer letters 2004;214(1):1-9.
2004: Takayuki Ueno; Stig Linder; Cheng-Lun Na; Ward R Rice; Jan Johansson; Timothy E Weaver
Processing of pulmonary surfactant protein B by napsin and cathepsin H.
The Journal of biological chemistry 2004;279(16):16178-84.
2004: Maria Hägg; Maria Berndtsson; Aleksandra Mandic; Rong Zhou; Maria C Shoshan; Stig Linder
Induction of endoplasmic reticulum stress by ellipticine plant alkaloids.
Molecular cancer therapeutics 2004;3(4):489-97.
2004: Gero Kramer; Hamdiye Erdal; Helena J M M Mertens; Marius Nap; Julian Mauermann; Georg Steiner; Michael Marberger; Kenneth Bivén; Maria C Shoshan; Stig Linder
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.
Cancer research 2004;64(5):1751-6.
2003: Kristina Viktorsson; Jessica Ekedahl; Maria C Lindebro; Rolf Lewensohn; Boris Zhivotovsky; Stig Linder; Maria C Shoshan
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line.
Experimental cell research 2003;289(2):256-64.
2003: Kenneth Bivén; Hamdiye Erdal; Maria Hägg; T Ueno; R Zhou; M Lynch; B Rowley; J Wood; C Zhang; M Toi; Maria C Shoshan; Stig Linder
A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera.
Apoptosis : an international journal on programmed cell death 2003;8(3):263-8.
2003: T Ueno; Stig Linder; G Elmberger
Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.
British journal of cancer 2003;88(8):1229-33.
2003: T Ueno; M Toi; Kenneth Bivén; H Bando; T Ogawa; Stig Linder
Measurement of an apoptotic product in the sera of breast cancer patients.
European journal of cancer (Oxford, England : 1990) 2003;39(6):769-74.
2003: Aleksandra Mandic; Johan Hansson; Stig Linder; Maria C Shoshan
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling.
The Journal of biological chemistry 2003;278(11):9100-6.
2002: Maria Hägg; Kenneth Bivén; Takayuki Ueno; Lars Rydlander; Peter Björklund; Klas G Wiman; Maria C Shoshan; Stig Linder
A novel high-through-put assay for screening of pro-apoptotic drugs.
Investigational new drugs 2002;20(3):253-9.
2002: Maria Seddighzadeh; Gunnar Steineck; Per Larsson; Hans Wijkström; Ulf Norming; Erik Onelöv; Stig Linder
Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms.
International journal of cancer. Journal international du cancer 2002;99(5):721-6.
2002: Aleksandra Mandic; Kristina Viktorsson; Linda Strandberg; Thomas Heiden; Johan Hansson; Stig Linder; Maria C Shoshan
Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis.
Molecular and cellular biology 2002;22(9):3003-13.
2002: Ayodele A Alaiya; Bo Franzén; Anders Hagman; Bjarte Dysvik; Uwe J Roblick; Susanne Becker; Birgitta Moberger; Gert Auer; Stig Linder
Molecular classification of borderline ovarian tumors using hierarchical cluster analysis of protein expression profiles.
International journal of cancer. Journal international du cancer 2002;98(6):895-9.
2001: Margareta Sten-Linder; M Seddighzadeh; G Engel; L E Rutqvist; Stig Linder; L Skoog; B Wima
Prognostic importance of the uPa/PAI-1 complex in breast cancer.
Anticancer research 2001;21(4B):2861-5.
2001: Aleksandra Mandic; Kristina Viktorsson; Magnus Molin; Göran Akusjärvi; H Eguchi; S I Hayashi; M Toi; Johan Hansson; Stig Linder; Maria C Shoshan
Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner.
Molecular and cellular biology 2001;21(11):3684-91.
2001: Maria Seddighzadeh; Gunnar Steineck; OT Jansson; Per Larsson; Hans Wijkström; Jan Adolfsson; N Portwood; J Hansson; Stig Linder
Low interleukin-1alpha messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma.
British journal of cancer 2001;84(3):329-34.
2001: Ayodele A Alaiya; M Oppermann; J Langridge; Uwe J Roblick; Lars Egevad; S Brindstedt; M Hellström; Stig Linder; Tomas Bergman; Hans Jörnvall; Gert Auer
Identification of proteins in human prostate tumor material by two-dimensional gel electrophoresis and mass spectrometry.
Cellular and molecular life sciences : CMLS 2001;58(2):307-11.
2001: Sushma Nordemar; Ulrike Kronenwett; Gert Auer; Anders Högmo; Johan Lindholm; S Edström; K Tryggvasson; Stig Linder; Eva Munck-Wikland
Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx.
Anticancer research 2001;21(1B):509-12.
2000: Kristina Viktorsson; Thomas Heiden; Magnus Molin; Göran Akusjärvi; Stig Linder; Maria C Shoshan
Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin.
Apoptosis : an international journal on programmed cell death 2000;5(4):355-67.
2000: M Seddighzadeh; Stig Linder; Maria C Shoshan; Gert Auer; Ayodele A Alaiya
Inhibition of extracellular signal-regulated kinase 1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression.
Electrophoresis 2000;21(13):2737-43.
2000: Ayodele A Alaiya; Bo Franzén; A Hagman; Claes Silfverswärd; Birgitta Moberger; Stig Linder; Gert Auer
Classification of human ovarian tumors using multivariate data analysis of polypeptide expression patterns.
International journal of cancer. Journal international du cancer 2000;86(5):731-6.
2000: Ayodele A Alaiya; Bo Franzén; Gert Auer; Stig Linder
Cancer proteomics: from identification of novel markers to creation of artifical learning models for tumor classification.
Electrophoresis 2000;21(6):1210-7.
2000: Ann-Charlotte Bergman; T Benjamin; Ayodele A Alaiya; Mark Waltham; K Sakaguchi; Bo Franzén; Stig Linder; Tomas Bergman; Gert Auer; Ettore Appella; PJ Wirth; Hans Jörnvall
Identification of gel-separated tumor marker proteins by mass spectrometry.
Electrophoresis 2000;21(3):679-86.
2000: Ayodele A Alaiya; Uwe J Roblick; Lars Egevad; A Carlsson; Bo Franzén; D Volz; Sören Huwendiek; Stig Linder; Gert Auer
Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 2000;21(1):1-9.
1999: Yutaka Chuman; A Bergman; T Ueno; S Saito; K Sakaguchi; Ayodele A Alaiya; Bo Franzén; Tomas Bergman; D Arnott; Gert Auer; Ettore Appella; Hans Jörnvall; Stig Linder
Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.
FEBS letters 1999;462(1-2):129-34.
1999: Margareta Sten-Linder; C Linder; Hans Strander; Eva Munck-Wikland; Peter Wersäll; Stig Linder; Björn Wiman
Angiostatin fragments in urine from patients with malignant disease.
Anticancer research 1999;19(4C):3409-14.
1999: Ayodele A Alaiya; Bo Franzén; Birgitta Moberger; Claes Silfverswärd; Stig Linder; Gert Auer
Two-dimensional gel analysis of protein expression in ovarian tumors shows a low degree of intratumoral heterogeneity.
Electrophoresis 1999;20(4-5):1039-46.
1999: Ann-Charlotte Bergman; Ayodele A Alaiya; W Wendler; B Binetruy; Maria C Shoshan; K Sakaguchi; Tomas Bergman; Ulrike Kronenwett; Gert Auer; Ettore Appella; Hans Jörnvall; Stig Linder
Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts.
Cellular and molecular life sciences : CMLS 1999;55(3):467-71.
1999: M Seddighzadeh; J N Zhou; Ulrike Kronenwett; Maria C Shoshan; Gert Auer; Margareta Sten-Linder; Björn Wiman; Stig Linder
ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation.
Clinical & experimental metastasis 1999;17(8):649-54.
1998: J N Zhou; J Hashemi; Khalil Helou; A Zhang; Dan Röhme; A Zetterberg; Göran Levan; Stig Linder
Analysis of mechanisms and frequency of CDKN2A/B gene loss during progression of RAS-transformed rat embryo fibroblast clones.
Somatic cell and molecular genetics 1998;24(6):327-39.
1998: Z Zhou; J Wang; X Han; J Zhou; Stig Linder
Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors.
International journal of cancer. Journal international du cancer 1998;78(1):95-9.
1998: J N Zhou; Stig Linder; Bo Franzén; G Auer; D F Hochstrasser; M A Persson
Rapid isolation of phage displayed antibodies to beta-actin eluted from two-dimensional electrophoresis gel.
Electrophoresis 1998;19(10):1808-10.
1998: S Ljungdahl; Stig Linder; Bo Franzén; B Binétruy; Gert Auer; Maria C Shoshan
Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):565-73.
1998: C Linder; Stig Linder; Eva Munck-Wikland; Hans Strander
Independent expression of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with carcinoma and sarcoma.
Anticancer research 1998;18(3B):2063-8.
1998: J N Zhou; S Ljungdahl; Maria C Shoshan; J Swedenborg; Stig Linder
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Molecular carcinogenesis 1998;21(4):234-43.
1998: C Linder; P Byström; G Engel; Gert Auer; Ulla Aspenblad; Hans Strander; Stig Linder
Correlation between basic fibroblast growth factor immunostaining of stromal cells and stromelysin-3 mRNA expression in human breast carcinoma.
British journal of cancer 1998;77(6):941-5.
1998: C Linder; Stig Linder; Eva Munck-Wikland; Gert Auer; Ulla Aspenblad; Hans Strander
Evaluation of tissue and serum VEGF in patients with head and neck carcinoma.
Angiogenesis 1998;2(4):365-72.
1997: Ayodele A Alaiya; Bo Franzén; K Fujioka; Birgitta Moberger; K Schedvins; C Silfversvärd; Stig Linder; Gert Auer
Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors.
International journal of cancer. Journal international du cancer 1997;73(5):678-83.
1997: Ann-Charlotte Bergman; C Linder; K Sakaguchi; Margareta Sten-Linder; Ayodele A Alaiya; Bo Franzén; Maria C Shoshan; Tomas Bergman; Björn Wiman; Gert Auer; Ettore Appella; Hans Jörnvall; Stig Linder
Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen.
FEBS letters 1997;417(1):17-20.
1997: S Ljungdahl; Stig Linder; K Sollerbrant; C Svensson; Maria C Shoshan
Signal transduction in fibroblasts stably transformed by [Val12]Ras--the activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated.
European journal of biochemistry / FEBS 1997;249(3):648-56.
1997: J N Zhou; S Ljungdahl; Dan Röhme; Göran Levan; Maria C Shoshan; Stig Linder
Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines.
Genes, chromosomes & cancer 1997;20(1):82-9.
1997: T Fokstuen; Y B Rabo; J N Zhou; J Karlson; A Platz; Maria C Shoshan; J Hansson; Stig Linder
The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line.
Anticancer research 1997;17(4A):2347-52.
1997: Bo Franzén; Stig Linder; Ayodele A Alaiya; E Eriksson; K Fujioka; Ann-Charlotte Bergman; Hans Jörnvall; Gert Auer
Analysis of polypeptide expression in benign and malignant human breast lesions.
Electrophoresis 1997;18(3-4):582-7.
1997: C Linder; G Engel; Gert Auer; Hans Strander; Stig Linder
Distribution of stromelysin-3 mRNA transcripts and microvessels in human breast carcinomas.
Breast cancer research and treatment 1997;42(3):207-13.
1997: S Ljungdahl; Maria C Shoshan; Stig Linder
Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-kappa B.
Anti-cancer drugs 1997;8(1):62-6.
1996: Bo Franzén; Stig Linder; Ayodele A Alaiya; E Eriksson; K Uruy; Takashi Hirano; K Okuzawa; Gert Auer
Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins.
British journal of cancer 1996;74(10):1632-8.
1996: Bo Franzén; Gert Auer; Ayodele A Alaiya; E Eriksson; K Uryu; Takashi Hirano; K Okuzawa; Harubumi Kato; Stig Linder
Assessment of homogeneity in polypeptide expression in breast carcinomas shows widely variable expression in highly malignant tumors.
International journal of cancer. Journal international du cancer 1996;69(5):408-14.
1996: J Karlson; A K Borg-Karlson; R Unelius; Maria C Shoshan; N Wilking; U Ringborg; Stig Linder
Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.
Anti-cancer drugs 1996;7(4):422-9.
1996: Bo Franzén; Stig Linder; K Uryu; Ayodele A Alaiya; Takashi Hirano; Harubumi Kato; Gert Auer
Expression of tropomyosin isoforms in benign and malignant human breast lesions.
British journal of cancer 1996;73(7):909-13.
1996: Y B Rabo; Maria C Shoshan; Stig Linder; Johan Hansson
Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light.
International journal of cancer. Journal international du cancer 1996;65(6):821-6.
1996: Maria C Shoshan; S Ljungdahl; Stig Linder
H-89 inhibits collagenase induction by phorbol ester through a mechanism that does not involve protein kinase A.
Cellular signalling 1996;8(3):191-5.
1995: R Zhao; Y B Rabo; Suzanne Egyházi; A Andersson; M R Edgren; Stig Linder; Johan Hansson
Apoptosis and c-jun induction by cisplatin in a human melanoma cell line and a drug-resistant daughter cell line.
Anti-cancer drugs 1995;6(5):657-68.
1995: Bo Franzén; T Hirano; K Okuzawa; K Uryu; Ayodele A Alaiya; Stig Linder; Gert Auer
Sample preparation of human tumors prior to two-dimensional electrophoresis of proteins.
Electrophoresis 1995;16(7):1087-9.
1995: K Sollerbrant; Göran Akusjärvi; Stig Linder; C Svensson
The DNA binding domains of the yeast Gal4 and human c-Jun transcription factors interact through the zinc-finger and bZIP motifs.
Nucleic acids research 1995;23(4):588-94.
1994: H Marshall-Heyman; G Engel; S Ljungdahl; Maria C Shoshan; C Svensson; B Wasylyk; Stig Linder
Tumorigenic and metastatic properties of two ras-oncogene transfected rat fibrosarcoma cell lines defective in c-jun.
Oncogene 1994;9(12):3655-63.
1994: G Engel; K Heselmeyer; Gert Auer; Martin Bäckdahl; E Eriksson; Stig Linder
Correlation between stromelysin-3 mRNA level and outcome of human breast cancer.
International journal of cancer. Journal international du cancer 1994;58(6):830-5.
1994: Maria C Shoshan; Stig Linder
Induction of the collagenase phorbol ester response element by staurosporine.
Journal of cellular biochemistry 1994;55(4):496-502.
1994: K Okuzawa; Bo Franzén; J Lindholm; Stig Linder; T Hirano; T Bergman; Y Ebihara; Harubumi Kato; Gert Auer
Characterization of gene expression in clinical lung cancer materials by two-dimensional polyacrylamide gel electrophoresis.
Electrophoresis 1994;15(3-4):382-90.
1993: Bo Franzén; Stig Linder; K Okuzawa; Harubumi Kato; Gert Auer
Nonenzymatic extraction of cells from clinical tumor material for analysis of gene expression by two-dimensional polyacrylamide gel electrophoresis.
Electrophoresis 1993;14(10):1045-53.
1993: H Marshall; P Popowicz; G Engel; I Martens; Stig Linder
Lack of c-jun expression in a transformed cell line isolated by glucocorticoid promotion of ras-transfected rat embryo fibroblasts.
Oncogene 1993;8(5):1303-9.
1993: P Popowicz; G Engel; H Marshall; Stig Linder
Repression of stromelysin metalloprotease expression in rat fibrosarcoma cells by dimethylsulfoxide.
Clinical & experimental metastasis 1993;11(1):77-82.
1992: M Bondesson; C Svensson; Stig Linder; Göran Akusjärvi
The carboxy-terminal exon of the adenovirus E1A protein is required for E4F-dependent transcription activation.
The EMBO journal 1992;11(9):3347-54.
1992: G Engel; P Popowicz; H Marshall; G Norling; C Svensson; G Auer; Göran Akusjärvi; Stig Linder
Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras.
International journal of cancer. Journal international du cancer 1992;51(5):761-6.
1992: Stig Linder
Nobel seminar: Molecular medicine--cell biology in disease. Cancer and HIV: from viral genes to therapy?
Journal of internal medicine 1992;232(1):3-9.
1992: Stig Linder; P Popowicz; C Svensson; H Marshall; M Bondesson; Göran Akusjärvi
Enhanced invasive properties of rat embryo fibroblasts transformed by adenovirus E1A mutants with deletions in the carboxy-terminal exon.
Oncogene 1992;7(3):439-43.
1991: C Svensson; M Bondesson; E Nyberg; Stig Linder; N Jones; Göran Akusjärvi
Independent transformation activity by adenovirus-5 E1A-conserved regions 1 or 2 mutants.
Virology 1991;182(2):553-61.
1991: H Marshall; I Martens; C Svensson; G Akusjärvi; Stig Linder
Glucocorticoid hormones may partially substitute for adenovirus E1A in cooperation with ras.
Experimental cell research 1991;194(1):35-41.
1990: Stig Linder; H Marshall
Immortalization of primary cells by DNA tumor viruses.
Experimental cell research 1990;191(1):1-7.
1990: Stig Linder; Mats Nilsson; I Martens; Göran Magnusson
A viable mouse polyomavirus mutant without immortalizing or transforming activities.
Virology 1990;179(1):78-86.
1990: I Martens; T Ramqvist; T Dalianis; Stig Linder
Complete transformation of embryonal rat fibroblasts by polyomavirus occurs during passage in vitro.
Experimental cell research 1990;187(1):143-9.
1989: I Martens; S A Nilsson; Stig Linder; Göran Magnusson
Mutational analysis of polyomavirus small-T-antigen functions in productive infection and in transformation.
Journal of virology 1989;63(5):2126-33.
1988: I Martens; Mats Nilsson; Göran Magnusson; Stig Linder
Glucocorticoids facilitate the stable transformation of embryonal rat fibroblasts by a polyomavirus large tumor antigen-deficient mutant.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5571-5.
1987: P J Ulfendahl; Stig Linder; Jan-Peter Kreivi; Katarina Nordqvist; C Sevensson; H Hultberg; Göran Akusjärvi
A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties.
The EMBO journal 1987;6(7):2037-44.