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John Lindon
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181
Nicholson, Jeremy
79
Holmes, Elaine
53
Wilson, Ian
23
Farrant, Duncan
21
Spraul, Manfred
16
Wang, Yulan
15
Nicholls, Andrew
14
Cloarec, Olivier
13
Kochhar, Sunil
13
Keun, Hector
12
Tang, Huiru
12
Ebbels, Timothy
11
Coen, Muireann
11
Lenz, Eva
10
Shockcor, John
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All Publications
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2009: Coen Muireann; Want Elizabeth J; Clayton T Andrew; Rhode Cynthia M; Hong Young Shick; Keun Hector C; Cantor Glenn H; Metz Alan L; Robertson Donald G; Reily Michael D; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.
Journal of proteome research 2009;8(11):5175-87.
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2009: Clayton T Andrew; Baker David; Lindon John C; Everett Jeremy R; Nicholson Jeremy K
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14728-33.
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2009: Warne M A; Nicholson J K; Lindon J C; Guiney P D; Gartland K P R
A QSAR investigation of dermal and respiratory chemical sensitizers based on computational chemistry properties.
SAR and QSAR in environmental research 2009;20(5):429-51.
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2009: Martin Francois-Pierre J; Wang Yulan; Yap Ivan K S; Sprenger Norbert; Lindon John C; Rezzi Serge; Kochhar Sunil; Holmes Elaine; Nicholson Jeremy K
Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity.
Journal of proteome research 2009;8(7):3464-74.
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2009: Berry Neil G; Iddon Lisa; Iqbal Mazhar; Meng Xiaoli; Jayapal Prabha; Johnson Caroline H; Nicholson Jeremy K; Lindon John C; Harding John R; Wilson Ian D; Stachulski Andrew V
Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1beta-O-acyl glucuronides.
Organic & biomolecular chemistry 2009;7(12):2525-33.
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2009: Smith Leon M; Maher Anthony D; Want Elizabeth J; Elliott Paul; Stamler Jeremiah; Hawkes Geoffrey E; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation.
Analytical chemistry 2009;81(12):4847-56.
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2009: Martin Francois-Pierre J; Sprenger Norbert; Yap Ivan K S; Wang Yulan; Bibiloni Rodrigo; Rochat Florence; Rezzi Serge; Cherbut Christine; Kochhar Sunil; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Panorganismal gut microbiome-host metabolic crosstalk.
Journal of proteome research 2009;8(4):2090-105.
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2009: Duarte Iola F; Legido-Quigley Cristina; Parker David A; Swann Jonathan R; Spraul Manfred; Braumann Ulrich; Gil Ana M; Holmes Elaine; Nicholson Jeremy K; Murphy Gerard M; Vilca-Melendez Hector; Heaton Nigel; Lindon John C
Identification of metabolites in human hepatic bile using 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS.
Molecular bioSystems 2009;5(2):180-90.
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2009: Maher Anthony D; Cloarec Olivier; Patki Prasad; Craggs Michael; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy.
Analytical chemistry 2009;81(1):288-95.
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2009: Veselkov Kirill A; Lindon John C; Ebbels Timothy M D; Crockford Derek; Volynkin Vladimir V; Holmes Elaine; Davies David B; Nicholson Jeremy K
Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery.
Analytical chemistry 2009;81(1):56-66.
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2008: Maher Anthony D; Patki Prasad; Lindon John C; Want Elizabeth J; Holmes Elaine; Craggs Michael; Nicholson Jeremy K
Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma.
Clinical chemistry 2008;54(12):2063-6.
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2008: Nicholson Jeremy K; Lindon John C
Systems biology: Metabonomics.
Nature 2008;455(7216):1054-6.
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2008: Maher Anthony D; Crockford Derek; Toft Henrik; Malmodin Daniel; Faber Johan H; McCarthy Mark I; Barrett Amy; Allen Maxine; Walker Mark; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes.
Analytical chemistry 2008;80(19):7354-62.
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2008: Bohus Eszter; Coen Muireann; Keun Hector C; Ebbels Timothy M D; Beckonert Olaf; Lindon John C; Holmes Elaine; Noszál Béla; Nicholson Jeremy K
Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis.
Journal of proteome research 2008;7(10):4435-45.
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2008: Pearce Jake T M; Athersuch Toby J; Ebbels Timothy M D; Lindon John C; Nicholson Jeremy K; Keun Hector C
Robust algorithms for automated chemical shift calibration of 1D 1H NMR spectra of blood serum.
Analytical chemistry 2008;80(18):7158-62.
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2008: Richards Selena E; Wang Yulan; Lawler Dennis; Kochhar Sunil; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs.
Analytical chemistry 2008;80(13):4876-85.
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2008: Johnson Caroline H; Athersuch Toby J; Wilson Ian D; Iddon Lisa; Meng Xiaoli; Stachulski Andrew V; Lindon John C; Nicholson Jeremy K
Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.
Analytical chemistry 2008;80(13):4886-95.
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2008: Lauridsen Michael; Maher Anthony D; Keun Hector; Lindon John C; Nicholson Jeremy K; Nyberg Nils T; Hansen Steen H; Cornett Claus; Jaroszewski Jerzy W
Application of the FLIPSY pulse sequence for increased sensitivity in 1H NMR-based metabolic profiling studies.
Analytical chemistry 2008;80(9):3365-71.
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2008: Keun Hector C; Athersuch Toby J; Beckonert Olaf; Wang Yulan; Saric Jasmina; Shockcor John P; Lindon John C; Wilson Ian D; Holmes Elaine; Nicholson Jeremy K
Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation.
Analytical chemistry 2008;80(4):1073-9.
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2008: Wang Yulan; Cloarec Olivier; Tang Huiru; Lindon John C; Holmes Elaine; Kochhar Sunil; Nicholson Jeremy K
Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies.
Analytical chemistry 2008;80(4):1058-66.
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2008: Coen Muireann; Holmes Elaine; Lindon John C; Nicholson Jeremy K
NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology.
Chemical research in toxicology 2008;21(1):9-27.
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2008: Saric Jasmina; Wang Yulan; Li Jia; Coen Muireann; Utzinger Jürg; Marchesi Julian R; Keiser Jennifer; Veselkov Kirill; Lindon John C; Nicholson Jeremy K; Holmes Elaine
Species variation in the fecal metabolome gives insight into differential gastrointestinal function.
Journal of proteome research 2008;7(1):352-60.
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2008: Martin Francois-Pierre J; Wang Yulan; Sprenger Norbert; Yap Ivan K S; Rezzi Serge; Ramadan Ziad; Peré-Trepat Emma; Rochat Florence; Cherbut Christine; van Bladeren Peter; Fay Laurent B; Kochhar Sunil; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.
Molecular systems biology 2008;4():205.
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2008: Martin Francois-Pierre J; Wang Yulan; Sprenger Norbert; Yap Ivan K S; Lundstedt Torbjörn; Lek Per; Rezzi Serge; Ramadan Ziad; van Bladeren Peter; Fay Laurent B; Kochhar Sunil; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.
Molecular systems biology 2008;4():157.
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2007: Duckett C J; Wilson I D; Douce D S; Walker H J; Abou-Shakra F R; Lindon J C; Nicholson J K
Metabolism of 2-fluoro-4-iodoaniline in earthworm Eisenia veneta using (19)F-NMR spectroscopy, HPLC-MS, and HPLC-ICPMS ((127)I).
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(12):1378-93.
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2007: Coen Muireann; Hong Young-Shick; Cloarec Olivier; Rhode Cindy M; Reily Michael D; Robertson Donald G; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.
Analytical chemistry 2007;79(23):8956-66.
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2007: Johnson Caroline H; Wilson Ian D; Harding John R; Stachulski Andrew V; Iddon Lisa; Nicholson Jeremy K; Lindon John C
NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues.
Analytical chemistry 2007;79(22):8720-7.
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2007: Rezzi Serge; Ramadan Ziad; Martin François-Pierre J; Fay Laurent B; van Bladeren Peter; Lindon John C; Nicholson Jeremy K; Kochhar Sunil
Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals.
Journal of proteome research 2007;6(11):4469-77.
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2007: Ebbels Timothy M D; Keun Hector C; Beckonert Olaf P; Bollard Mary E; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach.
Journal of proteome research 2007;6(11):4407-22.
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2007: Wang Yulan; Holmes Elaine; Comelli Elena M; Fotopoulos Grigorios; Dorta Gian; Tang Huiru; Rantalainen Mattias J; Lindon John C; Corthésy-Theulaz Irène E; Fay Laurent B; Kochhar Sunil; Nicholson Jeremy K
Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy.
Journal of proteome research 2007;6(10):3944-51.
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2007: Li Jia; Wang Yulan; Fenwick Alan; Clayton T Andrew; Lau Yu Y K; Legido-Quigley Cristina; Lindon John C; Utzinger Jürg; Holmes Elaine
A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets.
Journal of pharmaceutical and biomedical analysis 2007;45(2):263-7.
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2007: Smith Leon M; Maher Anthony D; Cloarec Olivier; Rantalainen Mattias; Tang Huiru; Elliott Paul; Stamler Jeremiah; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples.
Analytical chemistry 2007;79(15):5682-9.
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2007: Coen M; Hong Y S; Clayton T A; Rohde C M; Pearce J T; Reily M D; Robertson D G; Holmes E; Lindon J C; Nicholson J K
The mechanism of galactosamine toxicity revisited; a metabonomic study.
Journal of proteome research 2007;6(7):2711-9.
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2007: Teague Claire R; Dhabhar Firdaus S; Barton Richard H; Beckwith-Hall Bridgette; Powell Jonathan; Cobain Mark; Singer Burton; McEwen Bruce S; Lindon John C; Nicholson Jeremy K; Holmes Elaine
Metabonomic studies on the physiological effects of acute and chronic psychological stress in Sprague-Dawley rats.
Journal of proteome research 2007;6(6):2080-93.
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2007: Holmes Elaine; Loo Ruey Leng; Cloarec Olivier; Coen Muireann; Tang Huiru; Maibaum Elaine; Bruce Stephen; Chan Queenie; Elliott Paul; Stamler Jeremiah; Wilson Ian D; Lindon John C; Nicholson Jeremy K
Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.
Analytical chemistry 2007;79(7):2629-40.
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2007: Martin Francois-Pierre J; Wang Yulan; Sprenger Norbert; Holmes Elaine; Lindon John C; Kochhar Sunil; Nicholson Jeremy K
Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy.
Journal of proteome research 2007;6(4):1471-81.
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2007: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics in pharmaceutical R&D.
The FEBS journal 2007;274(5):1140-51.
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2007: Clayton T Andrew; Lindon John C; Everett Jeremy R; Charuel Claude; Hanton Gilles; Le Net Jean-Loic; Provost Jean-Pierre; Nicholson Jeremy K
Hepatotoxin-induced hypertyrosinemia and its toxicological significance.
Archives of toxicology 2007;81(3):201-10.
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2007: Beckonert Olaf; Keun Hector C; Ebbels Timothy M D; Bundy Jacob; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.
Nature protocols 2007;2(11):2692-703.
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2007: Martin François-Pierre J; Dumas Marc-Emmanuel; Wang Yulan; Legido-Quigley Cristina; Yap Ivan K S; Tang Huiru; Zirah Séverine; Murphy Gerard M; Cloarec Olivier; Lindon John C; Sprenger Norbert; Fay Laurent B; Kochhar Sunil; van Bladeren Peter; Holmes Elaine; Nicholson Jeremy K
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Molecular systems biology 2007;3():112.
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2006: Stachulski Andrew V; Harding John R; Lindon John C; Maggs James L; Park B Kevin; Wilson Ian D
Acyl glucuronides: biological activity, chemical reactivity, and chemical synthesis.
Journal of medicinal chemistry 2006;49(24):6931-45.
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2006: Stella Cinzia; Beckwith-Hall Bridgette; Cloarec Olivier; Holmes Elaine; Lindon John C; Powell Jonathan; van der Ouderaa Frans; Bingham Sheila; Cross Amanda J; Nicholson Jeremy K
Susceptibility of human metabolic phenotypes to dietary modulation.
Journal of proteome research 2006;5(10):2780-8.
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2006: Yap Ivan K S; Clayton T Andrew; Tang Huiru; Everett Jeremy R; Hanton Gilles; Provost Jean-Pierre; Le Net Jean-Loic; Charuel Claude; Lindon John C; Nicholson Jeremy K
An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate.
Journal of proteome research 2006;5(10):2675-84.
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2006: Martin Francois-Pierre J; Verdu Elena F; Wang Yulan; Dumas Marc-Emmanuel; Yap Ivan K S; Cloarec Olivier; Bergonzelli Gabriela E; Corthesy-Theulaz Irene; Kochhar Sunil; Holmes Elaine; Lindon John C; Collins Stephen M; Nicholson Jeremy K
Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.
Journal of proteome research 2006;5(9):2185-93.
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2006: Dumas Marc-Emmanuel; Barton Richard H; Toye Ayo; Cloarec Olivier; Blancher Christine; Rothwell Alice; Fearnside Jane; Tatoud Roger; Blanc Véronique; Lindon John C; Mitchell Steve C; Holmes Elaine; McCarthy Mark I; Scott James; Gauguier Dominique; Nicholson Jeremy K
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12511-6.
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2006: Wang Yulan; Holmes Elaine; Tang Huiru; Lindon John C; Sprenger Norbert; Turini Marco E; Bergonzelli Gabriela; Fay Laurent B; Kochhar Sunil; Nicholson Jeremy K
Experimental metabonomic model of dietary variation and stress interactions.
Journal of proteome research 2006;5(7):1535-42.
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2006: Crockford Derek J; Lindon John C; Cloarec Olivier; Plumb Robert S; Bruce Stephen J; Zirah Severine; Rainville Paul; Stumpf Chris L; Johnson Kelly; Holmes Elaine; Nicholson Jeremy K
Statistical search space reduction and two-dimensional data display approaches for UPLC-MS in biomarker discovery and pathway analysis.
Analytical chemistry 2006;78(13):4398-408.
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2006: Castle Arthur L; Fiehn Oliver; Kaddurah-Daouk Rima; Lindon John C
Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results.
Briefings in bioinformatics 2006;7(2):159-65.
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2006: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics techniques and applications to pharmaceutical research & development.
Pharmaceutical research 2006;23(6):1075-88.
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2006: Vanderhoeven Stephen J; Lindon John C; Troke Jeff; Nicholson Jeremy K; Wilson Ian D
NMR spectroscopic studies of the transacylation reactivity of ibuprofen 1-beta-O-acyl glucuronide.
Journal of pharmaceutical and biomedical analysis 2006;41(3):1002-6.
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2006: Clayton T Andrew; Lindon John C; Cloarec Olivier; Antti Henrik; Charuel Claude; Hanton Gilles; Provost Jean-Pierre; Le Net Jean-Loïc; Baker David; Walley Rosalind J; Everett Jeremy R; Nicholson Jeremy K
Pharmaco-metabonomic phenotyping and personalized drug treatment.
Nature 2006;440(7087):1073-7.
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2006: Craig Andrew; Cloarec Olivier; Holmes Elaine; Nicholson Jeremy K; Lindon John C
Scaling and normalization effects in NMR spectroscopic metabonomic data sets.
Analytical chemistry 2006;78(7):2262-7.
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2006: Dumas Marc-Emmanuel; Maibaum Elaine C; Teague Claire; Ueshima Hirotsugu; Zhou Beifan; Lindon John C; Nicholson Jeremy K; Stamler Jeremiah; Elliott Paul; Chan Queenie; Holmes Elaine
Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study.
Analytical chemistry 2006;78(7):2199-208.
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2006: Duckett C J; Lindon J C; Walker H; Abou-Shakra F; Wilson I D; Nicholson J K
Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(1):59-77.
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2006: Crockford Derek J; Holmes Elaine; Lindon John C; Plumb Robert S; Zirah Severine; Bruce Stephen J; Rainville Paul; Stumpf Chris L; Nicholson Jeremy K
Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies.
Analytical chemistry 2006;78(2):363-71.
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2005: Lindon John C; Keun Hector C; Ebbels Timothy Md; Pearce Jake Mt; Holmes Elaine; Nicholson Jeremy K
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements.
Pharmacogenomics 2005;6(7):691-9.
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2005: Duarte Iola F; Stanley Elizabeth G; Holmes Elaine; Lindon John C; Gil Ana M; Tang Huiru; Ferdinand Roxanne; McKee Claire Gavaghan; Nicholson Jeremy K; Vilca-Melendez Hector; Heaton Nigel; Murphy Gerard M
Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopy.
Analytical chemistry 2005;77(17):5570-8.
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2005: Skordi E; Wilson I D; Lindon J C; Nicholson J K
Kinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(7):715-25.
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2005: Wang Yulan; Tang Huiru; Holmes Elaine; Lindon John C; Turini Marco E; Sprenger Norbert; Bergonzelli Gabriela; Fay Laurent B; Kochhar Sunil; Nicholson Jeremy K
Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis.
Journal of proteome research 2005;4(4):1324-9.
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2005: Bollard Mary E; Stanley Elizabeth G; Lindon John C; Nicholson Jeremy K; Holmes Elaine
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition.
NMR in biomedicine 2005;18(3):143-62.
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2005: Bollard Mary E; Keun Hector C; Beckonert Olaf; Ebbels Tim M D; Antti Henrik; Nicholls Andrew W; Shockcor John P; Cantor Glenn H; Stevens Greg; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Comparative metabonomics of differential hydrazine toxicity in the rat and mouse.
Toxicology and applied pharmacology 2005;204(2):135-51.
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2005: Cloarec Olivier; Dumas Marc-Emmanuel; Craig Andrew; Barton Richard H; Trygg Johan; Hudson Jane; Blancher Christine; Gauguier Dominique; Lindon John C; Holmes Elaine; Nicholson Jeremy
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
Analytical chemistry 2005;77(5):1282-9.
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2005: Cloarec Olivier; Dumas Marc E; Trygg Johan; Craig Andrew; Barton Richard H; Lindon John C; Nicholson Jeremy K; Holmes Elaine
Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies.
Analytical chemistry 2005;77(2):517-26.
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2004: Skordi E; Wilson I D; Lindon J C; Nicholson J K
Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(11-12):1075-89.
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2004: Bundy Jacob G; Spurgeon David J; Svendsen Claus; Hankard Peter K; Weeks Jason M; Osborn Daniel; Lindon John C; Nicholson Jeremy K
Environmental metabonomics: applying combination biomarker analysis in earthworms at a metal contaminated site.
Ecotoxicology (London, England) 2004;13(8):797-806.
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2004: Ebbels Timothy M D; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Evaluation of metabolic variation in normal rat strains from a statistical analysis of 1H NMR spectra of urine.
Journal of pharmaceutical and biomedical analysis 2004;36(4):823-33.
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2004: Vanderhoeven S J; Troke J; Tranter G E; Wilson I D; Nicholson J K; Lindon J C
Nuclear magnetic resonance (NMR) and quantitative structure-activity relationship (QSAR) studies on the transacylation reactivity of model 1beta-O-acyl glucuronides. II: QSAR modelling of the reaction using both computational and experimental NMR parameters.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(10):889-900.
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2004: Nicholson Jeremy K; Holmes Elaine; Lindon John C; Wilson Ian D
The challenges of modeling mammalian biocomplexity.
Nature biotechnology 2004;22(10):1268-74.
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2004: Stoyanova Radka; Nicholls Andrew W; Nicholson Jeremy K; Lindon John C; Brown Truman R
Automatic alignment of individual peaks in large high-resolution spectral data sets.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;170(2):329-35.
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2004: Stoyanova Radka; Nicholson Jeremy K; Lindon John C; Brown Truman R
Sample classification based on Bayesian spectral decomposition of metabonomic NMR data sets.
Analytical chemistry 2004;76(13):3666-74.
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2004: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics: systems biology in pharmaceutical research and development.
Current opinion in molecular therapeutics 2004;6(3):265-72.
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2004: Coen Muireann; Wilson Ian D; Nicholson Jeremy K; Tang Huiru; Lindon John C
Probing molecular dynamics in chromatographic systems using high-resolution 1H magic-angle-spinning NMR spectroscopy: interaction between p-Xylene and C18-bonded silica.
Analytical chemistry 2004;76(11):3023-8.
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2004: Keun Hector C; Ebbels Timothy M D; Bollard Mary E; Beckonert Olaf; Antti Henrik; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles.
Chemical research in toxicology 2004;17(5):579-87.
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2004: Coen Muireann; Ruepp Stefan U; Lindon John C; Nicholson Jeremy K; Pognan François; Lenz Eva M; Wilson Ian D
Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse.
Journal of pharmaceutical and biomedical analysis 2004;35(1):93-105.
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2004: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics and its role in drug development and disease diagnosis.
Expert review of molecular diagnostics 2004;4(2):189-99.
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2004: Tang Huiru; Wang Yulan; Nicholson Jeremy K; Lindon John C
Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma.
Analytical biochemistry 2004;325(2):260-72.
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2004: Clayton T Andrew; Lindon John C; Everett Jeremy R; Charuel Claude; Hanton Gilles; Le Net Jean-Loic; Provost Jean-Pierre; Nicholson Jeremy K
Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status.
Archives of toxicology 2004;78(2):86-96.
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2004: Vanderhoeven S J; Lindon J C; Troke J; Tranter G E; Wilson I D; Nicholson J K
NMR and QSAR studies on the transacylation reactivity of model 1beta-O-acyl glucuronides. I: design, synthesis and degradation rate measurement.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(1):73-85.
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2004: Lindon John C; Holmes Elaine; Bollard Mary E; Stanley Elizabeth G; Nicholson Jeremy K
Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2004;9(1):1-31.
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2003: Wang Yulan; Bollard Mary E; Keun Hector; Antti Henrik; Beckonert Olaf; Ebbels Timothy M; Lindon John C; Holmes Elaine; Tang Huiru; Nicholson Jeremy K
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues.
Analytical biochemistry 2003;323(1):26-32.
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2003: Lindon John C
HPLC-NMR-MS: past, present and future.
Drug discovery today 2003;8(22):1021-2.
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2003: Lindon John C; Holmes Elaine; Nicholson Jeremy K
So what's the deal with metabonomics?
Analytical chemistry 2003;75(17):384A-391A.
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2003: Beckwith-Hall Bridgette M; Thompson Nicholas A; Nicholson Jeremy K; Lindon John C; Holmes Elaine
A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum.
The Analyst 2003;128(7):814-8.
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2003: Solanky Kirty S; Bailey Nigel J C; Holmes Elaine; Lindon John C; Davis Adrienne L; Mulder Theo P J; Van Duynhoven John P M; Nicholson Jeremy K
NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat.
Journal of agricultural and food chemistry 2003;51(14):4139-45.
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2003: Clayton T Andrew; Lindon John C; Everett Jeremy R; Charuel Claude; Hanton Gilles; Le Net Jean-Loic; Provost Jean-Pierre; Nicholson Jeremy K
An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria.
Archives of toxicology 2003;77(4):208-17.
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2003: Lindon John C; Nicholson Jeremy K; Holmes Elaine; Antti Henrik; Bollard Mary E; Keun Hector; Beckonert Olaf; Ebbels Timothy M; Reily Michael D; Robertson Donald; Stevens Gregory J; Luke Peter; Breau Alan P; Cantor Glenn H; Bible Roy H; Niederhauser Urs; Senn Hans; Schlotterbeck Goetz; Sidelmann Ulla G; Laursen Steen M; Tymiak Adrienne; Car Bruce D; Lehman-McKeeman Lois; Colet Jean Marie; Loukaci Ali; Thomas Craig
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
Toxicology and applied pharmacology 2003;187(3):137-46.
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2003: Coen Muireann; Lenz Eva M; Nicholson Jeremy K; Wilson Ian D; Pognan Francois; Lindon John C
An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy.
Chemical research in toxicology 2003;16(3):295-303.
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2003: Lenz E M; Lindon J C; Nicholson J K; Weeks J M; Osborn D
19F NMR spectroscopic investigation into the absorption and metabolism of 3-trifluoromethylaniline in Eisenia veneta.
Ecotoxicology and environmental safety 2003;54(2):157-68.
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2003: Tugnait M; Lenz E M; Hofmann M; Spraul M; Wilson I D; Lindon J C; Nicholson J K
The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy.
Journal of pharmaceutical and biomedical analysis 2003;30(5):1561-74.
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2003: Duckett Catherine J; Wilson Ian D; Walker Heather; Abou-Shakra Fadi; Lindon John C; Nicholson Jeremy K
High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4-iodoaniline.
Rapid communications in mass spectrometry : RCM 2003;17(16):1855-8.
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2002: Keun Hector C; Ebbels Timothy M D; Antti Henrik; Bollard Mary E; Beckonert Olaf; Schlotterbeck Götz; Senn Hans; Niederhauser Urs; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Analytical reproducibility in (1)H NMR-based metabonomic urinalysis.
Chemical research in toxicology 2002;15(11):1380-6.
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2002: Keun Hector C; Beckonert Olaf; Griffin Julian L; Richter Christian; Moskau Detlef; Lindon John C; Nicholson Jeremy K
Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies.
Analytical chemistry 2002;74(17):4588-93.
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2002: Beckwith-Hall Bridgette M; Holmes Elaine; Lindon John C; Gounarides John; Vickers Alison; Shapiro Michael; Nicholson Jeremy K
NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat.
Chemical research in toxicology 2002;15(9):1136-41.
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2002: Bundy Jacob G; Lenz Eva M; Bailey Nigel J; Gavaghan Claire L; Svendsen Claus; Spurgeon David; Hankard Peter K; Osborn Daniel; Weeks Jason M; Trauger Sunia A; Speir Paul; Sanders Ian; Lindon John C; Nicholson Jeremy K; Tang Huiru
Metabonomic assessment of toxicity of 4-fluoroaniline, 3,5-difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta (Rosa): identification of new endogenous biomarkers.
Environmental toxicology and chemistry / SETAC 2002;21(9):1966-72.
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2002: Lenz E M; Lindon J C; Nicholson J K; Weeks J M; Osborn D
19F-NMR and directly coupled 19F/1H-HPLC-NMR spectroscopic investigations of the metabolism of the model ecotoxin 3-trifluoromethylaniline in the earthworm species Eisenia veneta.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(6):535-46.
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2002: Bundy J G; Lenz E M; Osborn D; Weeks J M; Lindon J C; Nicholson J K
Metabolism of 4-fluoroaniline and 4-fluorobiphenyl in the earthworm Eisenia veneta characterized by high-resolution NMR spectroscopy with directly coupled HPLC-NMR and HPLC-MS.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(6):479-90.
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2002: Bundy Jacob G; Spurgeon David J; Svendsen Claus; Hankard Peter K; Osborn Daniel; Lindon John C; Nicholson Jeremy K
Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling.
FEBS letters 2002;521(1-3):115-20.
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2002: Tugnait M; Lenz E M; Phillips P; Hofmann M; Spraul M; Lindon J C; Nicholson J K; Wilson I D
The metabolism of 4-trifluoromethoxyaniline and [13C]-4-trifluoromethoxyacetanilide in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC-NMR.
Journal of pharmaceutical and biomedical analysis 2002;28(5):875-85.
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2002: Daykin Clare A; Foxall Peta J D; Connor Susan C; Lindon John C; Nicholson Jeremy K
The comparison of plasma deproteinization methods for the detection of low-molecular-weight metabolites by (1)H nuclear magnetic resonance spectroscopy.
Analytical biochemistry 2002;304(2):220-30.
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2002: Scarfe G B; Nicholson J K; Lindon J C; Wilson I D; Taylor S; Clayton E; Wright B
Identification of the urinary metabolites of 4-bromoaniline and 4-bromo-[carbonyl-13C]-acetanilide in rat.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):325-37.
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2002: Scarfe G B; Wilson I D; Warne M A; Holmes E; Nicholson J K; Lindon J C
Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):267-77.
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2002: Lenz E M; Wilson I D; Wright B; Partridge E A; Rodgers C T; Haycock P R; Lindon J C; Nicholson J K
A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat.
Journal of pharmaceutical and biomedical analysis 2002;28(1):31-43.
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2002: Nicholson Jeremy K; Connelly John; Lindon John C; Holmes Elaine
Metabonomics: a platform for studying drug toxicity and gene function.
Nature reviews. Drug discovery 2002;1(2):153-61.
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2002: Duckett Catherine J; Bailey Nigel J C; Walker Heather; Abou-Shakra Fadi; Wilson Ian D; Lindon John C; Nicholson Jeremy K
Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry investigated using diclofenac and chlorpromazine.
Rapid communications in mass spectrometry : RCM 2002;16(4):245-7.
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2001: Corcoran O; Lindon J C; Hall R; Ismail I M; Nicholson J K
The potential of 19F NMR spectroscopy for rapid screening of cell cultures for models of mammalian drug metabolism.
The Analyst 2001;126(12):2103-6.
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2001: Nicholls A W; Holmes E; Lindon J C; Shockcor J P; Farrant R D; Haselden J N; Damment S J; Waterfield C J; Nicholson J K
Metabonomic investigations into hydrazine toxicity in the rat.
Chemical research in toxicology 2001;14(8):975-87.
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2001: Bollard M E; Holmes E; Lindon J C; Mitchell S C; Branstetter D; Zhang W; Nicholson J K
Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition.
Analytical biochemistry 2001;295(2):194-202.
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2001: Bundy J G; Osborn D; Weeks J M; Lindon J C; Nicholson J K
An NMR-based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress.
FEBS letters 2001;500(1-2):31-5.
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2001: Coen M; Lindon J C; Gavaghan C; Holmes E; Humpfer E; Wilson I D; Stanley P D; Nicholson J K
Investigation of water environments in a C18 bonded silica phase using 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy.
The Analyst 2001;126(5):548-50.
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2001: Nicholson J K; Lindon J C; Scarfe G B; Wilson I D; Abou-Shakra F; Sage A B; Castro-Perez J
High-performance liquid chromatography linked to inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the simultaneous detection and identification of metabolites of 2-bromo-4-trifluoromethyl.
Analytical chemistry 2001;73(7):1491-4.
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2001: Tate A R; Damment S J; Lindon J C
Investigation of the metabolite variation in control rat urine using (1)H NMR spectroscopy.
Analytical biochemistry 2001;291(1):17-26.
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2001: Mortensen R W; Corcoran O; Cornett C; Sidelmann U G; Lindon J C; Nicholson J K; Hansen S H
S-naproxen-beta-1-O-acyl glucuronide degradation kinetic studies by stopped-flow high-performance liquid chromatography-1H NMR and high-performance liquid chromatography-UV.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 1):375-80.
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2001: Daykin C A; Corcoran O; Hansen S H; Bjørnsdottir I; Cornett C; Connor S C; Lindon J C; Nicholson J K
Application of directly coupled HPLC NMR to separation and characterization of lipoproteins from human serum.
Analytical chemistry 2001;73(6):1084-90.
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2001: Sidelmann U G; Bjørnsdottir I; Shockcor J P; Hansen S H; Lindon J C; Nicholson J K
Directly coupled HPLC-NMR and HPLC-MS approaches for the rapid characterisation of drug metabolites in urine: application to the human metabolism of naproxen.
Journal of pharmaceutical and biomedical analysis 2001;24(4):569-79.
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2001: Mortensen R W; Corcoran O; Cornett C; Sidelmann U G; Troke J; Lindon J C; Nicholson J K; Hansen S H
LC-1H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems.
Journal of pharmaceutical and biomedical analysis 2001;24(3):477-85.
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2000: Griffin J L; Troke J; Walker L A; Shore R F; Lindon J C; Nicholson J K
The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy.
FEBS letters 2000;486(3):225-9.
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2000: Shockcor J P; Unger S E; Savina P; Nicholson J K; Lindon J C
Application of directly coupled LC-NMR-MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):269-79.
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2000: Lindon J C; Nicholson J K; Wilson I D
Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):233-58.
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2000: Bollard M E; Garrod S; Holmes E; Lindon J C; Humpfer E; Spraul M; Nicholson J K
High-resolution (1)H and (1)H-(13)C magic angle spinning NMR spectroscopy of rat liver.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(2):201-7.
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2000: Scarfe G B; Lindon J C; Nicholson J K; Martin P; Wright B; Taylor S; Lenz E; Wilson I D
Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(7):717-29.
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2000: Waters N J; Garrod S; Farrant R D; Haselden J N; Connor S C; Connelly J; Lindon J C; Holmes E; Nicholson J K
High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition.
Analytical biochemistry 2000;282(1):16-23.
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2000: Holmes E; Nicholls A W; Lindon J C; Connor S C; Connelly J C; Haselden J N; Damment S J; Spraul M; Neidig P; Nicholson J K
Chemometric models for toxicity classification based on NMR spectra of biofluids.
Chemical research in toxicology 2000;13(6):471-8.
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2000: Tate A R; Foxall P J; Holmes E; Moka D; Spraul M; Nicholson J K; Lindon J C
Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of (1)H magic angle spinning (MAS) NMR spectra.
NMR in biomedicine 2000;13(2):64-71.
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2000: Nicholson J K; Lindon J C; Scarfe G; Wilson I D; Abou-Shakra F; Castro-Perez J; Eaton A; Preece S
High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline.
The Analyst 2000;125(2):235-6.
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2000: Bailey N J; Cooper P; Hadfield S T; Lenz E M; Lindon J C; Nicholson J K; Stanley P D; Wilson I D; Wright B; Taylor S D
Application of directly coupled HPLC-NMR-MS/MS to the identification of metabolites of 5-trifluoromethylpyridone (2-hydroxy-5-trifluoromethylpyridine) in hydroponically grown plants.
Journal of agricultural and food chemistry 2000;48(1):42-6.
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2000: Bailey N J; Stanley P D; Hadfield S T; Lindon J C; Nicholson J K
Mass spectrometrically detected directly coupled high performance liquid chromatography/nuclear magnetic resonance spectroscopy/mass spectrometry for the identification of xenobiotic metabolites in maize plants.
Rapid communications in mass spectrometry : RCM 2000;14(8):679-84.
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1999: Nicholson J K; Lindon J C; Holmes E
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(11):1181-9.
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1999: Scarfe G B; Lindon J C; Nicholson J K; Wright B; Clayton E; Wilson I D
Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(10):1171-8.
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1999: Nicholls A W; Lindon J C; Farrant R D; Shockcor J P; Wilson I D; Nicholson J K
Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat.
Journal of pharmaceutical and biomedical analysis 1999;20(6):865-73.
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1999: Warne M A; Osborn D; Lindon J C; Nicholson J K
Quantitative structure-toxicity relationships for halogenated substituted-benzenes to Vibrio fischeri, using atom-based semi-empirical molecular-orbital descriptors.
Chemosphere 1999;38(14):3357-82.
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1999: Garrod S; Humpfer E; Spraul M; Connor S C; Polley S; Connelly J; Lindon J C; Nicholson J K; Holmes E
High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(6):1108-18.
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1999: Abel C B; Lindon J C; Noble D; Rudd B A; Sidebottom P J; Nicholson J K
Characterization of metabolites in intact Streptomyces citricolor culture supernatants using high-resolution nuclear magnetic resonance and directly coupled high-pressure liquid chromatography-nuclear magnetic resonance spectroscopy.
Analytical biochemistry 1999;270(2):220-30.
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1999: Mistry N; Ismail I M; Farrant R D; Liu M; Nicholson J K; Lindon J C
Impurity profiling in bulk pharmaceutical batches using 19F NMR spectroscopy and distinction between monomeric and dimeric impurities by NMR-based diffusion measurements.
Journal of pharmaceutical and biomedical analysis 1999;19(3-4):511-7.
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1999: Scarfe G B; Wright B; Clayton E; Taylor S; Wilson I D; Lindon J C; Nicholson J K
Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):77-91.
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1999: Cupid B C; Holmes E; Wilson I D; Lindon J C; Nicholson J K
Quantitative structure-metabolism relationships (QSMR) using computational chemistry: pattern recognition analysis and statistical prediction of phase II conjugation reactions of substituted benzoic acids in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):27-42.
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1999: Warne M A; Boyd E M; Meharg A A; Osborn D; Killham K; Lindon J C; Nicholson J K
Quantitative structure-toxicity relationships for chlorophenols to bioluminescent lux-marked bacteria using atom-based semi-empirical molecular-orbital descriptors.
SAR and QSAR in environmental research 1999;10(5):473-95.
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1998: Schewitz J; Gfrörer P; Pusecker K; Tseng L H; Albert K; Bayer E; Wilson I D; Bailey N J; Scarfe G B; Nicholson J K; Lindon J C
Directly coupled CZE-NMR and CEC-NMR spectroscopy for metabolite analysis: paracetamol metabolites in human urine.
The Analyst 1998;123(12):2835-7.
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1998: Holmes E; Nicholls A W; Lindon J C; Ramos S; Spraul M; Neidig P; Connor S C; Connelly J; Damment S J; Haselden J; Nicholson J K
Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition.
NMR in biomedicine 1998;11(4-5):235-44.
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1998: Moka D; Vorreuther R; Schicha H; Spraul M; Humpfer E; Lipinski M; Foxall P J; Nicholson J K; Lindon J C
Biochemical classification of kidney carcinoma biopsy samples using magic-angle-spinning 1H nuclear magnetic resonance spectroscopy.
Journal of pharmaceutical and biomedical analysis 1998;17(1):125-32.
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1998: Scarfe G B; Wright B; Clayton E; Taylor S; Wilson I D; Lindon J C; Nicholson J K
19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(4):373-88.
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1998: Beckwith-Hall B M; Nicholson J K; Nicholls A W; Foxall P J; Lindon J C; Connor S C; Abdi M; Connelly J; Holmes E
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins.
Chemical research in toxicology 1998;11(4):260-72.
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1997: Corcoran O; Spraul M; Hofmann M; Ismail I M; Lindon J C; Nicholson J K
750 MHz HPLC-NMR spectroscopic identification of rat microsomal metabolites of phenoxypyridines.
Journal of pharmaceutical and biomedical analysis 1997;16(3):481-9.
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1997: Nicholls A W; Lindon J C; Caddick S; Farrant R D; Wilson I D; Nicholson J K
NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(11):1175-86.
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1997: Farrant R D; Cupid B C; Nicholson J K; Lindon J C
Investigation of the feasibility of directly-coupled HPLC-NMR with 2H detection with application to the metabolism of N-dimethylformamide-d7.
Journal of pharmaceutical and biomedical analysis 1997;16(1):1-5.
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1997: Lindon J C; Nicholson J K; Sidelmann U G; Wilson I D
Directly coupled HPLC-NMR and its application to drug metabolism.
Drug metabolism reviews 1997;29(3):705-46.
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1997: Humpfer E; Spraul M; Nicholls A W; Nicholson J K; Lindon J C
Direct observation of resolved intracellular and extracellular water signals in intact human red blood cells using 1H MAS NMR spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1997;38(2):334-6.
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1997: Holmes E; Foxall P J; Spraul M; Farrant R D; Nicholson J K; Lindon J C
750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease.
Journal of pharmaceutical and biomedical analysis 1997;15(11):1647-59.
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1997: Nicholls A W; Farrant R D; Shockcor J P; Unger S E; Wilson I D; Lindon J C; Nicholson J K
NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man.
Journal of pharmaceutical and biomedical analysis 1997;15(7):901-10.
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1997: Liu M; Nicholson J K; Parkinson J A; Lindon J C
Measurement of biomolecular diffusion coefficients in blood plasma using two-dimensional 1H-1H diffusion-edited total-correlation NMR spectroscopy.
Analytical chemistry 1997;69(8):1504-9.
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1996: Shockcor J P; Unger S E; Wilson I D; Foxall P J; Nicholson J K; Lindon J C
Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine.
Analytical chemistry 1996;68(24):4431-5.
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1996: Nicholls A W; Akira K; Lindon J C; Farrant R D; Wilson I D; Harding J; Killick D A; Nicholson J K
NMR spectroscopic and theoretical chemistry studies on the internal acyl migration reactions of the 1-O-acyl-beta-D-glucopyranuronate conjugates of 2-, 3-, and 4-(trifluoromethyl) benzoic acids.
Chemical research in toxicology 1996;9(8):1414-24.
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1996: Sidelmann U; Hansen S H; Gavaghan C; Nicholls A W; Carless H A; Lindon J C; Wilson I D; Nicholson J K
Development of a simple liquid chromatographic method for the separation of mixtures of positional isomers and anomers of synthetic 2-, 3- and 4-fluorobenzoic acid glucuronides formed via acyl migration reactions.
Journal of chromatography. B, Biomedical applications 1996;685(1):113-22.
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1996: Liu M; Nicholson J K; Lindon J C
High-resolution diffusion and relaxation edited one- and two-dimensional 1H NMR spectroscopy of biological fluids.
Analytical chemistry 1996;68(19):3370-6.
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1996: Lenz E M; Greatbanks D; Wilson I D; Spraul M; Hofmann M; Troke J; Lindon J C; Nicholson J K
Direct characterization of drug glucuronide isomers in human urine by HPLC-NMR spectroscopy: application to the positional isomers of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide.
Analytical chemistry 1996;68(17):2832-7.
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1996: Foxall P J; Lenz E M; Lindon J C; Neild G H; Wilson I D; Nicholson J K
Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide.
Therapeutic drug monitoring 1996;18(4):498-505.
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1996: Bollard M E; Holmes E; Blackledge C A; Lindon J C; Wilson I D; Nicholson J K
1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(3):255-73.
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1996: Shockcor J P; Wurm R M; Frick L W; Sanderson P N; Farrant R D; Sweatman B C; Lindon J C
Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV).
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):189-99.
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1996: Cupid B C; Beddell C R; Lindon J C; Wilson I D; Nicholson J K
Quantitative structure-metabolism relationships for substituted benzoic acids in the rabbit: prediction of urinary excretion of glycine and glucuronide conjugates.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):157-76.
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1996: Shockcor J P; Silver I S; Wurm R M; Sanderson P N; Farrant R D; Sweatman B C; Lindon J C
Characterization of in vitro metabolites from human liver microsomes using directly coupled hplc-nmr: application to a phenoxathiin monoamine oxidase-A inhibitor.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(1):41-8.
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1996: Sidelmann U G; Lenz E M; Spraul M; Hofmann M; Troke J; Sanderson P N; Lindon J C; Wilson I D; Nicholson J K
750 MHz HPLC-NMR spectroscopic studies on the separation and characterization of the positional isomers of the glucuronides of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid.
Analytical chemistry 1996;68(1):106-10.
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1995: Holmes E; Sweatman B C; Bollard M E; Blackledge C A; Beddell C R; Wilson I D; Lindon J C; Nicholson J K
Prediction of urinary sulphate and glucuronide conjugate excretion for substituted phenols in the rat using quantitative structure-metabolism relationships.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(12):1269-81.
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1995: Farrant R D; Spraul M; Wilson I D; Nicholls A W; Nicholson J K; Lindon J C
Assignment of the 750 MHz 1H NMR resonances from a mixture of transacylated ester glucuronic acid conjugates with the aid of oversampling and digital filtering during acquisition.
Journal of pharmaceutical and biomedical analysis 1995;13(8):971-7.
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1995: Holmes E; Caddick S; Lindon J C; Wilson I D; Kryvawych S; Nicholson J K
1H and 2H NMR spectroscopic studies on the metabolism and biochemical effects of 2-bromoethanamine in the rat.
Biochemical pharmacology 1995;49(10):1349-59.
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1995: Nicholls A W; Caddick S; Wilson I D; Farrant R D; Lindon J C; Nicholson J K
High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat.
Biochemical pharmacology 1995;49(8):1155-64.
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1995: Nicholson J K; Foxall P J; Spraul M; Farrant R D; Lindon J C
750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma.
Analytical chemistry 1995;67(5):793-811.
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1995: Anthony M L; Rose V S; Nicholson J K; Lindon J C
Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network.
Journal of pharmaceutical and biomedical analysis 1995;13(3):205-11.
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1994: Spraul M; Hofmann M; Lindon J C; Farrant R D; Seddon M J; Nicholson J K; Wilson I D
Evaluation of liquid chromatography coupled with high-field 1H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile.
NMR in biomedicine 1994;7(7):295-303.
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1994: Akira K; Farrant R D; Lindon J C; Caddick S T; Nicholls A W; Nicholson J K
High-field deuterium nuclear magnetic resonance spectroscopic monitoring of the pharmacokinetics of selectively deuterated benzoic acid in man.
Analytical biochemistry 1994;221(2):297-302.
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1994: Holmes E; Foxall P J; Nicholson J K; Neild G H; Brown S M; Beddell C R; Sweatman B C; Rahr E; Lindon J C; Spraul M
Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states.
Analytical biochemistry 1994;220(2):284-96.
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1994: Farrant R D; Lindon J C; Nicholson J K
Internal temperature calibration for 1H NMR spectroscopy studies of blood plasma and other biofluids.
NMR in biomedicine 1994;7(5):243-7.
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1994: Anthony M L; Sweatman B C; Beddell C R; Lindon J C; Nicholson J K
Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine.
Molecular pharmacology 1994;46(1):199-211.
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1994: Spraul M; Nicholson J K; Lynch M J; Lindon J C
Application of the one-dimensional TOCSY pulse sequence in 750 MHz 1H-NMR spectroscopy for assignment of endogenous metabolite resonances in biofluids.
Journal of pharmaceutical and biomedical analysis 1994;12(5):613-8.
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1994: Seddon M J; Spraul M; Wilson I D; Nicholson J K; Lindon J C
Improvement in the characterization of minor drug metabolites from HPLC-NMR studies through the use of quantified maximum entropy processing of NMR spectra.
Journal of pharmaceutical and biomedical analysis 1994;12(3):419-24.
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1994: Lynch M J; Masters J; Pryor J P; Lindon J C; Spraul M; Foxall P J; Nicholson J K
Ultra high field NMR spectroscopic studies on human seminal fluid, seminal vesicle and prostatic secretions.
Journal of pharmaceutical and biomedical analysis 1994;12(1):5-19.
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1994: Anthony M L; Gartland K P; Beddell C R; Lindon J C; Nicholson J K
Studies of the biochemical toxicology of uranyl nitrate in the rat.
Archives of toxicology 1994;68(1):43-53.
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1994: Anthony M L; Beddell C R; Lindon J C; Nicholson J K
Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat.
Archives of toxicology 1994;69(2):99-110.
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1993: Anthony M L; Beddell C R; Lindon J C; Nicholson J K
Raised transaminase activity of blood plasma from rats with experimentally-induced kidney damage detected by spin-echo 1H-NMR spectroscopy.
Journal of pharmaceutical and biomedical analysis 1993;11(10):897-902.
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1993: Farrant R D; Salman S R; Lindon J C; Cupid B C; Nicholson J K
Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide.
Journal of pharmaceutical and biomedical analysis 1993;11(8):687-92.
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1993: Sweatman B C; Farrant R D; Holmes E; Ghauri F Y; Nicholson J K; Lindon J C
600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances.
Journal of pharmaceutical and biomedical analysis 1993;11(8):651-64.
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1993: Ghauri F Y; Nicholson J K; Sweatman B C; Wood J; Beddell C R; Lindon J C; Cairns N J
NMR spectroscopy of human post mortem cerebrospinal fluid: distinction of Alzheimer's disease from control using pattern recognition and statistics.
NMR in biomedicine 1993;6(2):163-7.
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1993: Sweatman B C; Farrant R D; Lindon J C
NMR of biofluids: detection of 2H-acetate and 2H-formate in urine as an indicator of microbiological contamination.
Journal of pharmaceutical and biomedical analysis 1993;11(2):169-72.
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1993: Foxall P J; Parkinson J A; Sadler I H; Lindon J C; Nicholson J K
Analysis of biological fluids using 600 MHz proton NMR spectroscopy: application of homonuclear two-dimensional J-resolved spectroscopy to urine and blood plasma for spectral simplification and assignment.
Journal of pharmaceutical and biomedical analysis 1993;11(1):21-31.
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1993: Foxall P J; Mellotte G J; Bending M R; Lindon J C; Nicholson J K
NMR spectroscopy as a novel approach to the monitoring of renal transplant function.
Kidney international 1993;43(1):234-45.
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1993: Anthony M L; Beddell C R; Lindon J C; Nicholson J K
Studies on the effects of L(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat.
Archives of toxicology 1993;67(10):696-705.
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1992: Holmes E; Nicholson J K; Bonner F W; Sweatman B C; Beddell C R; Lindon J C; Rahr E
Mapping the biochemical trajectory of nephrotoxicity by pattern recognition of NMR urinanalysis.
NMR in biomedicine 1992;5(6):368-72.
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1992: Ghauri F Y; Blackledge C A; Glen R C; Sweatman B C; Lindon J C; Beddell C R; Wilson I D; Nicholson J K
Quantitative structure-metabolism relationships for substituted benzoic acids in the rat. Computational chemistry, NMR spectroscopy and pattern recognition studies.
Biochemical pharmacology 1992;44(10):1935-46.
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1992: Holmes E; Bonner F W; Sweatman B C; Lindon J C; Beddell C R; Rahr E; Nicholson J K
Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine.
Molecular pharmacology 1992;42(5):922-30.
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1992: Aulabaugh A E; Crouch R C; Martin G E; Ragouzeos A; Shockcor J P; Spitzer T D; Farrant R D; Hudson B D; Lindon J C
The conformational behaviour of the cardiac glycoside digoxin as indicated by NMR spectroscopy and molecular dynamics calculations.
Carbohydrate research 1992;230(2):201-12.
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1992: Farrant R D; Lindon J C; Rahr E; Sweatman B C
An automatic data reduction and transfer method to aid pattern recognition analysis and classification of NMR spectra.
Journal of pharmaceutical and biomedical analysis 1992;10(2-3):141-4.
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1992: Anthony M L; Gartland K P; Beddell C R; Lindon J C; Nicholson J K
Cephaloridine-induced nephrotoxicity in the Fischer 344 rat: proton NMR spectroscopic studies of urine and plasma in relation to conventional clinical chemical and histopathological assessments of nephronal damage.
Archives of toxicology 1992;66(8):525-37.
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1991: Gartland K P; Beddell C R; Lindon J C; Nicholson J K
Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine.
Molecular pharmacology 1991;39(5):629-42.
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1991: Carpenter T A; Hodgson R J; Herrod N J; Hall L D; Lindon J C; Honey A C; Martin J F
Magnetic resonance imaging in a model of atherosclerosis: use of a collar around the rabbit carotid artery.
Magnetic resonance imaging 1991;9(3):365-71.
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1990: Gartland K P; Sanins S M; Nicholson J K; Sweatman B C; Beddell C R; Lindon J C
Pattern recognition analysis of high resolution 1H NMR spectra of urine. A nonlinear mapping approach to the classification of toxicological data.
NMR in biomedicine 1990;3(4):166-72.
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1990: Booth R F; Honey A C; Martin J F; Lindon J C; Farrant R D; Carpenter T A; Hall L D
Lipid characterization in an animal model of atherosclerosis using NMR spectroscopy and imaging.
NMR in biomedicine 1990;3(2):95-100.
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1990: Gartland K P; Anthony M L; Beddell C R; Lindon J C; Nicholson J K
Proton NMR studies on the effects of uranyl nitrate on the biochemical composition of rat urine and plasma.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):951-4.
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1990: Gartland K P; Beddell C R; Lindon J C; Nicholson J K
A pattern recognition approach to the comparison of PMR and clinical chemical data for classification of nephrotoxicity.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):963-8.
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