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Mark Lindsay

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Hanna M Larner-Svensson; Andrew Williams; Eleni Tsitsiou; Mark M Perry; Xiaoying Jiang; Kian F Chung; Mark A Lindsay
Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle.
Mark M Perry; Andrew Williams; Eleni Tsitsiou; Hanna M Larner-Svensson; Mark A Lindsay
Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells.
Andrew Williams; Hanna Larner-Svensson; Mark M Perry; Gaynor A Campbell; Sarah E Herrick; Ian M Adcock; Jonas S Erjefalt; Kian Fan Chung; Mark A Lindsay
MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy.

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All Publications

2010: Hanna M Larner-Svensson; Andrew Williams; Eleni Tsitsiou; Mark M Perry; Xiaoying Jiang; Kian F Chung; Mark A Lindsay
Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle.
Respiratory research 2010;11():68.
2009: Mark M Perry; Andrew Williams; Eleni Tsitsiou; Hanna M Larner-Svensson; Mark A Lindsay
Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells.
FEBS letters 2009;583(20):3349-55.
2009: Andrew Williams; Hanna Larner-Svensson; Mark M Perry; Gaynor A Campbell; Sarah E Herrick; Ian M Adcock; Jonas S Erjefalt; Kian Fan Chung; Mark A Lindsay
MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy.
PloS one 2009;4(6):e5889.
2008: Andrew Williams; Mark M Perry; Sterghios A Moschos; Hanna M Larner-Svensson; Mark A Lindsay
Role of miRNA-146a in the regulation of the innate immune response and cancer.
Biochemical Society transactions 2008;36(Pt 6):1211-5.
2008: Mark A Lindsay
microRNAs and the immune response.
Trends in immunology 2008;29(7):343-51.
2008: Mark M Perry; Sterghios A Moschos; Andrew Williams; Neil J Shepherd; Hanna M Larner-Svensson; Mark A Lindsay
Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5689-98.
2007: Sterghios A Moschos; Simon W Jones; Mark M Perry; Andrew Williams; Jonas Sten Erjefalt; John J Turner; Peter J Barnes; Brian Stephen Sproat; Michael J Gait; Mark A Lindsay
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
Bioconjugate chemistry 2007;18(5):1450-9.
2007: Sterghios A Moschos; Andrew Williams; Mark A Lindsay
Cell-penetrating-peptide-mediated siRNA lung delivery.
Biochemical Society transactions 2007;35(Pt 4):807-10.
2007: Andrew Williams; Sterghios A Moschos; Mark M Perry; Peter J Barnes; Mark A Lindsay
Maternally imprinted microRNAs are differentially expressed during mouse and human lung development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(2):572-80.
2007: Sterghios A Moschos; Andrew Williams; Mark M Perry; Mark A Birrell; Maria G Belvisi; Mark A Lindsay
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids.
BMC genomics 2007;8():240.
2007: Andrew Williams; Mark M Perry; Sterghios A Moschos; Mark A Lindsay
microRNA expression in the aging mouse lung.
BMC genomics 2007;8():172.
2007: John J Turner; Simon W Jones; Sterghios A Moschos; Mark A Lindsay; Michael J Gait
MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity.
Molecular bioSystems 2007;3(1):43-50.
2005: Mark A Lindsay
Finding new drug targets in the 21st century.
Drug discovery today 2005;10(23-24):1683-7.
2005: Simon W Jones; Richard Christison; Ken Bundell; Catherine J Voyce; Sarah M V Brockbank; Peter Newham; Mark A Lindsay
Characterisation of cell-penetrating peptide-mediated peptide delivery.
British journal of pharmacology 2005;145(8):1093-102.
2005: Patricia M De Souza; Mark A Lindsay
Apoptosis as a therapeutic target for the treatment of lung disease.
Current opinion in pharmacology 2005;5(3):232-7.
2004: Simon W Jones; Mark A Lindsay
Overview of target validation and the impact of oligonucleotides.
Current opinion in molecular therapeutics 2004;6(5):546-50.
2004: Simon W Jones; Patricia M de Souza; Mark A Lindsay
siRNA for gene silencing: a route to drug target discovery.
Current opinion in pharmacology 2004;4(5):522-7.
2004: Patricia M De Souza; Mark A Lindsay
Mammalian Sterile20-like kinase 1 and the regulation of apoptosis.
Biochemical Society transactions 2004;32(Pt3):485-8.
2003: Xianzhi Zhang; Eeva Moilanen; Aleksi Lahti; Mari Hämäläinen; Mark A Giembycz; Peter J Barnes; Mark A Lindsay; Hannu Kankaanranta
Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.
The Journal of allergy and clinical immunology 2003;112(1):93-101.
2003: Isabelle Green; Richard Christison; Catherine J Voyce; Ken R Bundell; Mark A Lindsay
Protein transduction domains: are they delivering?
Trends in pharmacological sciences 2003;24(5):213-5.
2002: Xianzhi Zhang; Eeva Moilanen; Ian M Adcock; Mark A Lindsay; Hannu Kankaanranta
Divergent effect of mometasone on human eosinophil and neutrophil apoptosis.
Life sciences 2002;71(13):1523-34.
2002: Patricia M De Souza; Hannu Kankaanranta; Ashour Michael; Peter J Barnes; Mark A Giembycz; Mark A Lindsay
Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis.
Blood 2002;99(9):3432-8.
2002: Hannu Kankaanranta; Mark A Giembycz; Peter J Barnes; El-Bdaoui Haddad; Seppo Saarelainen; Xianzhi Zhang; Eeva Moilanen; Mark A Lindsay
Hydrogen peroxide reverses IL-5 afforded eosinophil survival and promotes constitutive human eosinophil apoptosis.
International archives of allergy and immunology 2002;127(1):73-8.
2001: OT Lynch; Mark A Giembycz; Peter J Barnes; Mark A Lindsay
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
British journal of pharmacology 2001;134(4):797-806.
2000: koremu meja; Paul M Seldon; Yasuyuki Nasuhara; Kazuhiro Ito; Peter J Barnes; Mark A Lindsay; Mark A Giembycz
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism.
British journal of pharmacology 2000;131(6):1143-53.
2000: A Koch; Yasuyuki Nasuhara; Peter J Barnes; Mark A Lindsay; Mark A Giembycz
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
British journal of pharmacology 2000;131(5):981-9.
2000: Robert Newton; Lisa M Cambridge; LA Hart; DA Stevens; Mark A Lindsay; Peter J Barnes
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
British journal of pharmacology 2000;130(6):1353-61.
2000: Hannu Kankaanranta; Mark A Lindsay; Mark A Giembycz; X Zhang; E Moilanen; Peter J Barnes
Delayed eosinophil apoptosis in asthma.
The Journal of allergy and clinical immunology 2000;106(1 Pt 1):77-83.
2000: OT Lynch; Mark A Giembycz; I Daniels; Peter J Barnes; Mark A Lindsay
Pleiotropic role of lyn kinase in leukotriene B(4)-induced eosinophil activation.
Blood 2000;95(11):3541-7.
2000: Hannu Kankaanranta; P M de Souza; Mark A Giembycz; Mark A Lindsay
Human eosinophil isolation and the measurement of apoptosis.
Methods in molecular medicine 2000;44():99-110.
2000: P M de Souza; Hannu Kankaanranta; Mark A Giembycz; Mark A Lindsay
MAP Kinase Expression in Eosinophils.
Methods in molecular medicine 2000;44():91-8.
2000: Mark A Giembycz; OT Lynch; Patricia M De Souza; Mark A Lindsay
Review: G-protein-coupled receptors on eosinophils.
Pulmonary pharmacology & therapeutics 2000;13(5):195-223.
1999: Mauro Teixeira; Mark A Lindsay; Mark A Giembycz; Paul G Hellewell
Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.
European journal of pharmacology 1999;384(2-3):183-90.
1999: OT Lynch; Mark A Giembycz; Peter J Barnes; Paul G Hellewell; Mark A Lindsay
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
British journal of pharmacology 1999;128(6):1149-58.
1999: D J Evans; Mark A Lindsay; BL Webb; Hannu Kankaanranta; Mark A Giembycz; Brian J O'connor; Peter J Barnes
Expression and activation of protein kinase C-zeta in eosinophils after allergen challenge.
The American journal of physiology 1999;277(2 Pt 1):L233-9.
1999: Hannu Kankaanranta; Patricia M De Souza; Peter J Barnes; Michael Salmon; Mark A Giembycz; Mark A Lindsay
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils.
The Journal of pharmacology and experimental therapeutics 1999;290(2):621-8.
1999: Mark A Giembycz; Mark A Lindsay
Pharmacology of the eosinophil.
Pharmacological reviews 1999;51(2):213-340.
1998: Mark A Lindsay; EB Haddad; J Rousell; Mauro Teixeira; Paul G Hellewell; Peter J Barnes; Mark A Giembycz
Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation.
Journal of leukocyte biology 1998;64(4):555-62.
1998: I Daniels; Mark A Lindsay; C I Keany; Richard Burden; J Fletcher; Andrew P Haynes
Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent.
Clinical and diagnostic laboratory immunology 1998;5(5):683-9.
1998: Mark A Lindsay; R S Perkins; Peter J Barnes; Mark A Giembycz
Leukotriene B4 activates the NADPH oxidase in eosinophils by a pertussis toxin-sensitive mechanism that is largely independent of arachidonic acid mobilization.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4526-34.
1997: J Rousell; Mark A Lindsay; Peter J Barnes
Regulation of m2 muscarinic receptor gene expression by platelet-derived growth factor: involvement of extracellular signal-regulated protein kinases in the down-regulation process.
Molecular pharmacology 1997;52(6):966-73.
1997: Mark A Lindsay; I Daniels; J Fletcher
Phospholipases and the activation and priming of neutrophils by peritoneal dialysis effluent.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1997;17(5):471-9.
1997: BL Webb; Mark A Lindsay; J Seybold; N J Brand; Magdi H Yacoub; EB Haddad; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level.
Biochemical pharmacology 1997;54(1):199-205.
1997: Mauro Teixeira; Mark A Giembycz; Mark A Lindsay; Paul G Hellewell
Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo.
Blood 1997;89(12):4566-73.
1997: BL Webb; Mark A Lindsay; Peter J Barnes; Mark A Giembycz
Protein kinase C isoenzymes in airway smooth muscle.
The Biochemical journal 1997;324 ( Pt 1)():167-75.
1997: Mark A Lindsay; Mark A Giembycz
Signal transduction and activation of the NADPH oxidase in eosinophils.
Memórias do Instituto Oswaldo Cruz 1997;92 Suppl 2():115-23.
1996: EB Haddad; J Rousell; Mark A Lindsay; Peter J Barnes
Synergy between tumor necrosis factor alpha and interleukin 1beta in inducing transcriptional down-regulation of muscarinic M2 receptor gene expression. Involvement of protein kinase A and ceramide pathways.
The Journal of biological chemistry 1996;271(51):32586-92.
1996: I Daniels; K S Bhatia; C J Porter; Mark A Lindsay; Anthony G Morgan; Richard Burden; J Fletcher
Hydrogen peroxide generation by polymorphonuclear leukocytes exposed to peritoneal dialysis effluent.
Clinical and diagnostic laboratory immunology 1996;3(6):682-8.
1996: D J Evans; Mark A Lindsay; Brian J O'connor; Peter J Barnes
Priming of circulating human eosinophils following late response to allergen challenge.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(4):703-8.
1996: Mark A Lindsay; I Daniels; J Fletcher
Investigation of the role of protein kinase C and tyrosine kinases during the rapid and sustained release of superoxide from adherent human neutrophils.
Biochemical Society transactions 1996;24(1):67S.
1995: R S Perkins; Mark A Lindsay; Peter J Barnes; Mark A Giembycz
Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.
The Biochemical journal 1995;310 ( Pt 3)():795-806.
1994: I Daniels; S P Crouch; Mark A Lindsay; Anthony G Morgan; Richard Burden; J Fletcher
Primary and secondary granule release by polymorphonuclear leukocytes exposed to peritoneal dialysis effluent.
Clinical and diagnostic laboratory immunology 1994;1(2):227-31.