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Christopher Lingle

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TOP 3
Yu Zhou; Xu-Hui Zeng; Christopher J Lingle
Barium ions selectively activate BK channels via the Ca2+-bowl site.
Vivian Gonzalez-Perez; Katie Henzler-Wildman; Xu-Hui Zeng; Christopher J Lingle
Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.
Chengtao Yang; Xu-Hui Zeng; Yu Zhou; Xiao-Ming Xia; Christopher J Lingle
LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.

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All Publications

2012: Yu Zhou; Xu-Hui Zeng; Christopher J Lingle
Barium ions selectively activate BK channels via the Ca2+-bowl site.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11413-8.
2012: Vivian Gonzalez-Perez; Katie Henzler-Wildman; Xu-Hui Zeng; Christopher J Lingle
Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.
Nature 2012;485(7396):133-6.
2011: Chengtao Yang; Xu-Hui Zeng; Yu Zhou; Xiao-Ming Xia; Christopher J Lingle
LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19419-24.
2011: Yu Zhou; Xiao-Ming Xia; Christopher J Lingle
Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):12161-6.
2011: Xu-Hui Zeng; Chengtao Yang; Sung Tae Kim; Christopher J Lingle; Xiao-Ming Xia
Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5879-84.
2010: Yu Zhou; Xiaoming Xia; Christopher J Lingle
Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.
Molecular pharmacology 2010;78(5):952-60.
2010: Yu Zhou; Qiong-Yao Tang; Xiao-Ming Xia; Christopher J Lingle
Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.
The Journal of general physiology 2010;135(5):481-94.
2010: Qiong-Yao Tang; Zhe Zhang; Xiao-Ming Xia; Christopher J Lingle
Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.
Channels (Austin, Tex.) 2010;4(1):22-41.
2009: Qiong-Yao Tang; Xu-Hui Zeng; Christopher J Lingle
Closed-channel block of BK potassium channels by bbTBA requires partial activation.
The Journal of general physiology 2009;134(5):409-36.
2009: Zhe Zhang; Xu-Hui Zeng; Xiao-Ming Xia; Christopher J Lingle
N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels.
The Journal of general physiology 2009;133(3):263-82.
2009: Cheng-Tao Yang; Xu-Hui Zeng; Xiao-Ming Xia; Christopher J Lingle
Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function.
PloS one 2009;4(7):e6135.
2008: Xuhui Zeng; Xiao-Ming Xia; Christopher J Lingle
Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits.
The Journal of general physiology 2008;132(1):115-29.
2007: Xu-Hui Zeng; G Richard Benzinger; Xiao-Ming Xia; Christopher J Lingle
BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(17):4707-15.
2007: Christopher J Lingle
Gating rings formed by RCK domains: keys to gate opening.
The Journal of general physiology 2007;129(2):101-7.
2006: Zhe Zhang; Yu Zhou; Jiu-Ping Ding; Xiao-Ming Xia; Christopher J Lingle
A limited access compartment between the pore domain and cytosolic domain of the BK channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):11833-43.
2006: Christopher J Lingle
Empirical considerations regarding the use of ensemble-variance analysis of macroscopic currents.
Journal of neuroscience methods 2006;158(1):121-32.
2006: Xue Zhang; Xuhui Zeng; Christopher J Lingle
Slo3 K+ channels: voltage and pH dependence of macroscopic currents.
The Journal of general physiology 2006;128(3):317-36.
2006: Xue Zhang; Xuhui Zeng; Xiao-Ming Xia; Christopher J Lingle
pH-regulated Slo3 K+ channels: properties of unitary currents.
The Journal of general physiology 2006;128(3):301-15.
2006: G Richard Benzinger; Xiao-Ming Xia; Christopher J Lingle
Direct observation of a preinactivated, open state in BK channels with beta2 subunits.
The Journal of general physiology 2006;127(2):119-31.
2005: Xiao-Ke Chen; Lie-Cheng Wang; Yang Zhou; Qian Cai; Murali Prakriya; Kailai Duan; Zu-Hang Sheng; Christopher J Lingle; Zhuan Zhou
Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC.
Nature neuroscience 2005;8(9):1160-8.
2005: Xu-Hui Zeng; Xiao-Ming Xia; Christopher J Lingle
Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.
The Journal of general physiology 2005;125(3):273-86.
2004: Xiao-Ming Xia; Xue Zhang; Christopher J Lingle
Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(24):5585-91.
2003: Xu-Hui Zeng; Xiao-Ming Xia; Christopher J Lingle
Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels.
Nature structural biology 2003;10(6):448-54.
2003: Xiao-Ming Xia; Jiu-Ping Ding; Christopher J Lingle
Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues.
The Journal of general physiology 2003;121(2):125-48.
2002: Christopher J Lingle
Setting the stage for molecular dissection of the regulatory components of BK channels.
The Journal of general physiology 2002;120(3):261-5.
2002: Xiao-Ming Xia; Xuhui Zeng; Christopher J Lingle
Multiple regulatory sites in large-conductance calcium-activated potassium channels.
Nature 2002;418(6900):880-4.
2002: Jiu-Ping Ding; Christopher J Lingle
Steady-state and closed-state inactivation properties of inactivating BK channels.
Biophysical journal 2002;82(5):2448-65.
2002: Ying-Wei Wang; Jiu-Ping Ding; Xiao-Ming Xia; Christopher J Lingle
Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1550-61.
2001: Xue Zhang; C R Solaro; Christopher J Lingle
Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site.
The Journal of general physiology 2001;118(5):607-36.
2001: Xu-Hui Zeng; Jiu-Ping Ding; Xiao-Ming Xia; Christopher J Lingle
Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini.
The Journal of general physiology 2001;117(6):607-28.
2001: Christopher J Lingle; Xu-Hui Zeng; Jiu-Ping Ding; Xiao-Ming Xia
Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.
The Journal of general physiology 2001;117(6):583-606.
2000: Murali Prakriya; Christopher J Lingle
Activation of BK channels in rat chromaffin cells requires summation of Ca(2+) influx from multiple Ca(2+) channels.
Journal of neurophysiology 2000;84(3):1123-35.
2000: Xiao-Ming Xia; Jiu-Ping Ding; Xu-Hui Zeng; K L Duan; Christopher J Lingle
Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(13):4890-903.
2000: Slobodan M Todorovic; Edward Perez-Reyes; Christopher J Lingle
Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants.
Molecular pharmacology 2000;58(1):98-108.
1999: Xiao-Ming Xia; Jiu-Ping Ding; Christopher J Lingle
Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(13):5255-64.
1999: YM Nakashima; A Pereverzev; Toni Schneider; Douglas F Covey; Christopher J Lingle
Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN.
Neuropharmacology 1999;38(6):843-55.
1999: Murali Prakriya; Christopher J Lingle
BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells.
Journal of neurophysiology 1999;81(5):2267-78.
1999: ZW Li; Jiu-Ping Ding; Vani Kalyanaraman; Christopher J Lingle
RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels.
Journal of neurophysiology 1999;81(2):611-24.
1998: Slobodan M Todorovic; Murali Prakriya; YM Nakashima; Kent R Nilsson; M Han; Charles F Zorumski; Douglas F Covey; Christopher J Lingle
Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity.
Molecular pharmacology 1998;54(5):918-27.
1998: YM Nakashima; Slobodan M Todorovic; Douglas F Covey; Christopher J Lingle
The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat.
Molecular pharmacology 1998;54(3):559-68.
1998: YM Nakashima; Slobodan M Todorovic; A Pereverzev; J Hescheler; Toni Schneider; Christopher J Lingle
Properties of Ba2+ currents arising from human alpha1E and alpha1Ebeta3 constructs expressed in HEK293 cells: physiology, pharmacology, and comparison to native T-type Ba2+ currents.
Neuropharmacology 1998;37(8):957-72.
1998: Jiu-Ping Ding; ZW Li; Christopher J Lingle
Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivating subunits.
Biophysical journal 1998;74(1):268-89.
1998: Slobodan M Todorovic; Christopher J Lingle
Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.
Journal of neurophysiology 1998;79(1):240-52.
1997: C R Solaro; Jiu-Ping Ding; ZW Li; Christopher J Lingle
The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers.
Biophysical journal 1997;73(2):819-30.
1997: M Saito; C Nelson; L Salkoff; Christopher J Lingle
A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells.
The Journal of biological chemistry 1997;272(18):11710-7.
1996: Murali Prakriya; C R Solaro; Christopher J Lingle
[Ca2+]i elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(14):4344-59.
1996: Christopher J Lingle; C R Solaro; Murali Prakriya; Jiu-Ping Ding
Calcium-activated potassium channels in adrenal chromaffin cells.
Ion channels 1996;4():261-301.
1995: D P McCobb; N L Fowler; T Featherstone; Christopher J Lingle; M Saito; J E Krause; Lawrence Salkoff
A human calcium-activated potassium channel gene expressed in vascular smooth muscle.
The American journal of physiology 1995;269(3 Pt 2):H767-77.
1995: C R Solaro; Murali Prakriya; Jiu-Ping Ding; Christopher J Lingle
Inactivating and noninactivating Ca(2+)- and voltage-dependent K+ current in rat adrenal chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(9):6110-23.
1995: J Herrington; C R Solaro; Alan Neely; Christopher J Lingle
The suppression of Ca(2+)- and voltage-dependent outward K+ current during mAChR activation in rat adrenal chromaffin cells.
The Journal of physiology 1995;485 ( Pt 2)():297-318.
1994: Aguan Wei; C Solaro; Christopher J Lingle; Lawrence Salkoff
Calcium sensitivity of BK-type KCa channels determined by a separable domain.
Neuron 1994;13(3):671-81.
1994: J Herrington; Christopher J Lingle
Multiple components of voltage-dependent potassium current in normal rat anterior pituitary cells.
Journal of neurophysiology 1994;72(2):719-29.
1993: J L Albert; Christopher J Lingle
Activation of nicotinic acetylcholine receptors on cultured Drosophila and other insect neurones.
The Journal of physiology 1993;463():605-30.
1992: C R Solaro; Christopher J Lingle
Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel.
Science (New York, N.Y.) 1992;257(5077):1694-8.
1992: J Herrington; Christopher J Lingle
Kinetic and pharmacological properties of low voltage-activated Ca2+ current in rat clonal (GH3) pituitary cells.
Journal of neurophysiology 1992;68(1):213-32.
1992: Christopher J Lingle; D Maconochie; Joe Henry Steinbach
Activation of skeletal muscle nicotinic acetylcholine receptors.
The Journal of membrane biology 1992;126(3):195-217.
1992: Alan Neely; Christopher J Lingle
Two components of calcium-activated potassium current in rat adrenal chromaffin cells.
The Journal of physiology 1992;453():97-131.
1992: Alan Neely; Christopher J Lingle
Effects of muscarine on single rat adrenal chromaffin cells.
The Journal of physiology 1992;453():133-66.
1991: R C Stern; J Herrington; Christopher J Lingle; A S Evers
The action of halothane on stimulus-secretion coupling in clonal (GH3) pituitary cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(7):2217-25.
1991: J Herrington; R C Stern; A S Evers; Christopher J Lingle
Halothane inhibits two components of calcium current in clonal (GH3) pituitary cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(7):2226-40.
1991: J Herrington; Christopher J Lingle
Halothane reduces calcium currents in clonal (GH3) pituitary cells.
Annals of the New York Academy of Sciences 1991;625():290-2.
1989: Christopher J Lingle
Anomalous voltage dependence of channel blockade at a crustacean glutamate-mediated synapse.
The Journal of physiology 1989;409():403-30.
1988: Christopher J Lingle; Joe Henry Steinbach
Neuromuscular blocking agents.
International anesthesiology clinics 1988;26(4):288-301.
1986: Alan Neely; Christopher J Lingle
Trapping of an open-channel blocker at the frog neuromuscular acetylcholine channel.
Biophysical journal 1986;50(5):981-6.