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Joachim Lingner

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Saccharomyces cerevisiae

Concepts & Ideas

Molecular Sequence Data

Physiology

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DNA Damage

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Publications

TOP 3
Malika Makhlouf Brahmi; Cyril Portmann; Patrick Reichenbach; Gerardo Turcatti; Tom M Woods; Damiano Banfi; Emilie Baudat; Laeticia Da Silva; Danilo D'Ambrosio; Joachim Lingner; Karl Gademann
Telomerase inhibitors from cyanobacteria: isolation and synthesis of sulfoquinovosyl diacylglycerols from Microcystis aeruguinosa PCC 7806.
Anselm Sauerwald; Sjors H W Scheres; Gael Cristofari; Joachim Lingner; Sara Sandin; Daniela Rhodes
Structure of active dimeric human telomerase.
Amitabha Gupta; Joachim Lingner; Lisette Marjavaara; Anna Karin Nilsson; Patrick Reichenbach; Rodney Rothstein; Sushma Sharma; Andrei Chabes; Michael Chang
Telomere length homeostasis responds to changes in intracellular dNTP pools.

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All Publications

2013: Malika Makhlouf Brahmi; Cyril Portmann; Patrick Reichenbach; Gerardo Turcatti; Tom M Woods; Damiano Banfi; Emilie Baudat; Laeticia Da Silva; Danilo D'Ambrosio; Joachim Lingner; Karl Gademann
Telomerase inhibitors from cyanobacteria: isolation and synthesis of sulfoquinovosyl diacylglycerols from Microcystis aeruguinosa PCC 7806.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(14):4596-601.
2013: Anselm Sauerwald; Sjors H W Scheres; Gael Cristofari; Joachim Lingner; Sara Sandin; Daniela Rhodes
Structure of active dimeric human telomerase.
Nature structural & molecular biology 2013;20(4):454-60.
2013: Amitabha Gupta; Joachim Lingner; Lisette Marjavaara; Anna Karin Nilsson; Patrick Reichenbach; Rodney Rothstein; Sushma Sharma; Andrei Chabes; Michael Chang
Telomere length homeostasis responds to changes in intracellular dNTP pools.
Genetics 2013;193(4):1095-105.
2013: Verena Pfeiffer; Joachim Lingner
Replication of telomeres and the regulation of telomerase.
Cold Spring Harbor perspectives in biology 2013;5(5):.
2012: Liuh-Yow Chen; Sophie Redon; Joachim Lingner
The human CST complex is a terminator of telomerase activity.
Nature 2012;488(7412):540-4.
2012: Liuh-Yow Chen; Joachim Lingner
AUF1/HnRNP D RNA binding protein functions in telomere maintenance.
Molecular cell 2012;47(1):1-2.
2012: Danilo D'Ambrosio; Marco Franceschin; Emanuela Micheli; Patrick Reichenbach; Maria Savino; Antonello Alvino; Joachim Lingner
Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase.
Biochimie 2012;94(3):854-63.
2012: Verena Pfeiffer; Joachim Lingner
TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends.
PLoS genetics 2012;8(6):e1002747.
2011: Nahid Iglesias; Sophie Redon; Verena Pfeiffer; Martina Dees; Joachim Lingner; Brian Luke
Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast.
EMBO reports 2011;12(6):587-93.
2010: Antonio Porro; Sascha Feuerhahn; Patrick Reichenbach; Joachim Lingner
Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways.
Molecular and cellular biology 2010;30(20):4808-17.
2010: Sascha Feuerhahn; Nahid Iglesias; Andrea Panza; Antonio Porro; Joachim Lingner
TERRA biogenesis, turnover and implications for function.
FEBS letters 2010;584(17):3812-8.
2010: Sophie Redon; Patrick Reichenbach; Joachim Lingner
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase.
Nucleic acids research 2010;38(17):5797-806.
2010: Eladio Abreu; Elena Aritonovska; Patrick Reichenbach; Gaël Cristofari; Brad Culp; Rebecca M Terns; Joachim Lingner; Michael P Terns
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Molecular and cellular biology 2010;30(12):2971-82.
2009: Michael Chang; Brian Luke; Claudine Kraft; Zhijian Li; Matthias Peter; Joachim Lingner; Rodney Rothstein
Telomerase is essential to alleviate pif1-induced replication stress at telomeres.
Genetics 2009;183(3):779-91.
2009: Brian Luke; Joachim Lingner
TERRA: telomeric repeat-containing RNA.
The EMBO journal 2009;28(17):2503-10.
2009: Nahid Iglesias; Joachim Lingner
Related mechanisms for end processing at telomeres and DNA double-strand breaks.
Molecular cell 2009;35(2):137-8.
2008: Brian Luke; Andrea Panza; Sophie Redon; Nahid Iglesias; Zhijian Li; Joachim Lingner
The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae.
Molecular cell 2008;32(4):465-77.
2008: Claus M Azzalin; Joachim Lingner
Telomeres: the silence is broken.
Cell cycle (Georgetown, Tex.) 2008;7(9):1161-5.
2008: Michael Chang; Joachim Lingner
Cell signaling. Tel2 finally tells one story.
Science (New York, N.Y.) 2008;320(5872):60-1.
2008: Isabel Kurth; Gael Cristofari; Joachim Lingner
An affinity oligonucleotide displacement strategy to purify ribonucleoprotein complexes applied to human telomerase.
Methods in molecular biology (Clifton, N.J.) 2008;488():9-22.
2007: Claus M Azzalin; Patrick Reichenbach; Lela Khoriauli; Elena Giulotto; Joachim Lingner
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Science (New York, N.Y.) 2007;318(5851):798-801.
2007: Milica Arnerić; Joachim Lingner
Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.
EMBO reports 2007;8(11):1080-5.
2007: Anne DE CIAN; Gael Cristofari; Patrick Reichenbach; Elsa De Lemos; David Monchaud; Marie-Paule Teulade-Fichou; Kazuo Shin-Ya; Laurent Lacroix; Joachim Lingner; Jean-Louis Mergny
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17347-52.
2007: Michael Chang; Milica Arneric; Joachim Lingner
Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae.
Genes & development 2007;21(19):2485-94.
2007: Gael Cristofari; Patrick Reichenbach; Pierre-Olivier Regamey; Damiano Banfi; Marc Chambon; Gerardo Turcatti; Joachim Lingner
Low- to high-throughput analysis of telomerase modulators with Telospot.
Nature methods 2007;4(10):851-3.
2007: Gael Cristofari; Emem Adolf; Patrick Reichenbach; Katarzyna Sikora; Rebecca M Terns; Michael P Terns; Joachim Lingner
Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation.
Molecular cell 2007;27(6):882-9.
2007: Claus M Azzalin; Joachim Lingner
Molecular biology: damage control.
Nature 2007;448(7157):1001-2.
2007: Gael Cristofari; Katarzyna Sikora; Joachim Lingner
Telomerase unplugged.
ACS chemical biology 2007;2(3):155-8.
2007: Brian Luke; Claus M Azzalin; Nele Hug; Anna Deplazes; Matthias Peter; Joachim Lingner
Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.
Nucleic acids research 2007;35(22):7688-97.
2007: Sophie Redon; Patrick Reichenbach; Joachim Lingner
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase.
Nucleic acids research 2007;35(20):7011-22.
2006: Nele Hug; Joachim Lingner
Telomere length homeostasis.
Chromosoma 2006;115(6):413-25.
2006: Anne Eugster; Chiara Lanzuolo; Manon Bonneton; Pierre Luciano; Alessandra Pollice; John F Pulitzer; Emma Stegberg; Anne-Sophie Berthiau; Klaus Förstemann; Yves Corda; Joachim Lingner; Vincent Géli; Eric Gilson
The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.
Nature structural & molecular biology 2006;13(8):734-9.
2006: Claus M Azzalin; Joachim Lingner
The double life of UPF1 in RNA and DNA stability pathways.
Cell cycle (Georgetown, Tex.) 2006;5(14):1496-8.
2006: Claus M Azzalin; Joachim Lingner
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.
Current biology : CB 2006;16(4):433-9.
2006: Gael Cristofari; Joachim Lingner
Telomere length homeostasis requires that telomerase levels are limiting.
The EMBO journal 2006;25(3):565-74.
2005: Klaus Förstemann; Joachim Lingner
Telomerase limits the extent of base pairing between template RNA and telomeric DNA.
EMBO reports 2005;6(4):361-6.
2005: Colleen Kelleher; Isabel Kurth; Joachim Lingner
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro.
Molecular and cellular biology 2005;25(2):808-18.
2004: M Teresa Teixeira; Milica Arneric; Peter Sperisen; Joachim Lingner
Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.
Cell 2004;117(3):323-35.
2004: Claus M Azzalin; Joachim Lingner
Cell biology. Telomere wedding ends in divorce.
Science (New York, N.Y.) 2004;304(5667):60-2.
2003: Gael Cristofari; Joachim Lingner
Fingering the ends: how to make new telomeres.
Cell 2003;113(5):552-4.
2003: Patrick Reichenbach; Matthias Höss; Claus M Azzalin; Markus Nabholz; Philipp Bucher; Joachim Lingner
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed.
Current biology : CB 2003;13(7):568-74.
2003: Klaus Förstemann; Arthur J Zaug; Thomas R Cech; Joachim Lingner
Yeast telomerase is specialized for C/A-rich RNA templates.
Nucleic acids research 2003;31(6):1646-55.
2003: Henrietta Szutorisz; Joachim Lingner; Andrew P Cuthbert; Deborah A Trott; Robert F Newbold; Markus Nabholz
A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin.
Cancer research 2003;63(3):689-95.
2002: Colleen Kelleher; M Teresa Teixeira; Klaus Förstemann; Joachim Lingner
Telomerase: biochemical considerations for enzyme and substrate.
Trends in biochemical sciences 2002;27(11):572-9.
2002: Anne-Lyse Ducrest; Mario Amacker; Joachim Lingner; Markus Nabholz
Detection of promoter activity by flow cytometric analysis of GFP reporter expression.
Nucleic acids research 2002;30(14):e65.
2002: M Teresa Teixeira; Klaus Forstemann; Susan Gasser; Joachim Lingner
Intracellular trafficking of yeast telomerase components.
EMBO reports 2002;3(7):652-9.
2002: Emanuelle Pascolo; Christian Wenz; Joachim Lingner; Norbert H Hauel; Henning Priepke; Iris Kauffmann; Pilar Garin-Chesa; Wolfgang J Rettig; Klaus Damm; Andreas Schnapp
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.
The Journal of biological chemistry 2002;277(18):15566-72.
2002: Anne-Lyse Ducrest; Henrietta Szutorisz; Joachim Lingner; Markus Nabholz
Regulation of the human telomerase reverse transcriptase gene.
Oncogene 2002;21(4):541-52.
2001: Klaus Damm; U Hemmann; Pilar Garin-Chesa; Norbert H Hauel; I Kauffmann; Henning Priepke; C Niestroj; C Daiber; B Enenkel; B Guilliard; I Lauritsch; E Müller; E Pascolo; G Sauter; Milena Pantic; Uwe M Martens; Christian Wenz; Joachim Lingner; Norbert Kraut; Wolfgang J Rettig; Andreas Schnapp
A highly selective telomerase inhibitor limiting human cancer cell proliferation.
The EMBO journal 2001;20(24):6958-68.
2001: Klaus Förstemann; Joachim Lingner
Molecular basis for telomere repeat divergence in budding yeast.
Molecular and cellular biology 2001;21(21):7277-86.
2001: Anne-Lyse Ducrest; Mario Amacker; Y D Mathieu; Andrew P Cuthbert; Deborah A Trott; Robert F Newbold; Markus Nabholz; Joachim Lingner
Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.
Cancer research 2001;61(20):7594-602.
2001: Christian Wenz; B Enenkel; Mario Amacker; Colleen Kelleher; Klaus Damm; Joachim Lingner
Human telomerase contains two cooperating telomerase RNA molecules.
The EMBO journal 2001;20(13):3526-34.
2001: Henrietta Szutorisz; Richard Palmqvist; G Roos; Roger Stenling; D F Schorderet; R Reddel; Joachim Lingner; Markus Nabholz
Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas.
Oncogene 2001;20(20):2600-5.
2000: Klaus Förstemann; M Höss; Joachim Lingner
Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres.
Nucleic acids research 2000;28(14):2690-4.
1999: Kou-Juey Wu; Carla Grandori; Mario Amacker; N Simon-Vermot; Axel Polack; Joachim Lingner; Riccardo Dalla-Favera
Direct activation of TERT transcription by c-MYC.
Nature genetics 1999;21(2):220-4.
1998: Joachim Lingner; Thomas R Cech
Telomerase and chromosome end maintenance.
Current opinion in genetics & development 1998;8(2):226-32.