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Robert Linhardt

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

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Kemp Melissa M; Kumar Ashavani; Mousa Shaymaa; Dyskin Evgeny; Yalcin Murat; Ajayan Pulickel; Linhardt Robert J; Mousa Shaker A
Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties.
Zhang Zhenqing; Li Boyangzi; Suwan Jiraporn; Zhang Fuming; Wang Zhenyu; Liu Haiying; Mulloy Barbara; Linhardt Robert J
Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE.
Guerrini Marco; Zhang Zhenqing; Shriver Zachary; Naggi Annamaria; Masuko Sayaka; Langer Robert; Casu Benito; Linhardt Robert J; Torri Giangiacomo; Sasisekharan Ram
Orthogonal analytical approaches to detect potential contaminants in heparin.

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All Publications

2009: Kemp Melissa M; Kumar Ashavani; Mousa Shaymaa; Dyskin Evgeny; Yalcin Murat; Ajayan Pulickel; Linhardt Robert J; Mousa Shaker A
Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties.
Nanotechnology 2009;20(45):455104.
2009: Zhang Zhenqing; Li Boyangzi; Suwan Jiraporn; Zhang Fuming; Wang Zhenyu; Liu Haiying; Mulloy Barbara; Linhardt Robert J
Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE.
Journal of pharmaceutical sciences 2009;98(11):4017-26.
2009: Guerrini Marco; Zhang Zhenqing; Shriver Zachary; Naggi Annamaria; Masuko Sayaka; Langer Robert; Casu Benito; Linhardt Robert J; Torri Giangiacomo; Sasisekharan Ram
Orthogonal analytical approaches to detect potential contaminants in heparin.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):16956-61.
2009: Ra Hyun-Jeong; Harju-Baker Susanna; Zhang Fuming; Linhardt Robert J; Wilson Carole L; Parks William C
Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans.
The Journal of biological chemistry 2009;284(41):27924-32.
2009: Burana-osot Jankana; Hosoyama Saori; Nagamoto Yuzu; Suzuki Sho; Linhardt Robert J; Toida Toshihiko
Photolytic depolymerization of alginate.
Carbohydrate research 2009;344(15):2023-7.
2009: Zhang Fuming; Zhang Zhenqing; Lin Xinfu; Beenken Andrew; Eliseenkova Anna V; Mohammadi Moosa; Linhardt Robert J
Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexes.
Biochemistry 2009;48(35):8379-86.
2009: Martin Jeffrey G; Gupta Megha; Xu Yongmei; Akella Srinivas; Liu Jian; Dordick Jonathan S; Linhardt Robert J
Toward an artificial Golgi: redesigning the biological activities of heparan sulfate on a digital microfluidic chip.
Journal of the American Chemical Society 2009;131(31):11041-8.
2009: Li Boyangzi; Suwan Jiraporn; Martin Jeffrey G; Zhang Fuming; Zhang Zhenqing; Hoppensteadt Debra; Clark Melanie; Fareed Jawed; Linhardt Robert J
Oversulfated chondroitin sulfate interaction with heparin-binding proteins: new insights into adverse reactions from contaminated heparins.
Biochemical pharmacology 2009;78(3):292-300.
2009: Mora-Pale Mauricio; Weïwer Michel; Yu Jingjing; Linhardt Robert J; Dordick Jonathan S
Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols.
Bioorganic & medicinal chemistry 2009;17(14):5146-52.
2009: Suwan Jiraporn; Zhang Zhenqing; Li Boyangzi; Vongchan Preeyanat; Meepowpan Puttinan; Zhang Fuming; Mousa Shaker A; Mousa Shaymaa; Premanode Bhusana; Kongtawelert Prachya; Linhardt Robert J
Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity.
Carbohydrate research 2009;344(10):1190-6.
2009: Sava Irina G; Zhang Fuming; Toma Ioana; Theilacker Christian; Li Boyangzhi; Baumert Thomas F; Holst Otto; Linhardt Robert J; Huebner Johannes
Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells.
The Journal of biological chemistry 2009;284(27):18194-201.
2009: Kemp Melissa M; Kumar Ashavani; Clement Dylan; Ajayan Pulickel; Mousa Shaker; Linhardt Robert J
Hyaluronan- and heparin-reduced silver nanoparticles with antimicrobial properties.
Nanomedicine (London, England) 2009;4(4):421-9.
2009: Zhang Zhenqing; Xie Jin; Liu Haiying; Liu Jian; Linhardt Robert J
Quantification of heparan sulfate disaccharides using ion-pairing reversed-phase microflow high-performance liquid chromatography with electrospray ionization trap mass spectrometry.
Analytical chemistry 2009;81(11):4349-55.
2009: Toida Toshihiko; Sato Kenji; Sakamoto Noriko; Sakai Shinobu; Hosoyama Saori; Linhardt Robert J
Solvolytic depolymerization of chondroitin and dermatan sulfates.
Carbohydrate research 2009;344(7):888-93.
2009: Volpi Nicola; Maccari Francesca; Linhardt Robert J
Quantitative capillary electrophoresis determination of oversulfated chondroitin sulfate as a contaminant in heparin preparations.
Analytical biochemistry 2009;388(1):140-5.
2009: Simmons Trevor J; Bult Justin; Hashim Daniel P; Linhardt Robert J; Ajayan Pulickel M
Noncovalent functionalization as an alternative to oxidative acid treatment of single wall carbon nanotubes with applications for polymer composites.
ACS nano 2009;3(4):865-70.
2009: Lee Sang Hyun; Doherty Thomas V; Linhardt Robert J; Dordick Jonathan S
Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis.
Biotechnology and bioengineering 2009;102(5):1368-76.
2009: Liu Haiying; Zhang Zhenqing; Linhardt Robert J
Lessons learned from the contamination of heparin.
Natural product reports 2009;26(3):313-21.
2009: Kemp Melissa M; Kumar Ashavani; Mousa Shaymaa; Park Tae-Joon; Ajayan Pulickel; Kubotera Natsuki; Mousa Shaker A; Linhardt Robert J
Synthesis of gold and silver nanoparticles stabilized with glycosaminoglycans having distinctive biological activities.
Biomacromolecules 2009;10(3):589-95.
2009: Zhang Zhenqing; Park Youmie; Kemp Melissa M; Zhao Wenjing; Im A-Rang; Shaya David; Cygler Miroslaw; Kim Yeong Shik; Linhardt Robert J
Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern.
Analytical biochemistry 2009;385(1):57-64.
2009: Zhang Fuming; Zhang Zhenqing; Thistle Robert; McKeen Lindsey; Hosoyama Saori; Toida Toshihiko; Linhardt Robert J; Page-McCaw Patrick
Structural characterization of glycosaminoglycans from zebrafish in different ages.
Glycoconjugate journal 2009;26(2):211-8.
2009: Han Juying; Zhang Fuming; Xie Jin; Linhardt Robert J; Hiebert Linda M
Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin.
Cardiovascular diabetology 2009;8():46.
2009: Wolff Jeremy J; Laremore Tatiana N; Leach Ii Franklin E; Linhardt Robert J; Amster I Jonathan
Electron capture dissociation, electron detachment dissociation and infrared multiphoton dissociation of sucrose octasulfate.
European journal of mass spectrometry (Chichester, England) 2009;15(2):275-81.
2008: Park Tae-Joon; Lee Moo-Yeal; Dordick Jonathan S; Linhardt Robert J
Signal amplification of target protein on heparin glycan microarray.
Analytical biochemistry 2008;383(1):116-21.
2008: Park Youmie; Zhang Zhenqing; Laremore Tatiana N; Li Boyangzi; Sim Joon-Soo; Im A-Rang; Ahn Mi Young; Kim Yeong Shik; Linhardt Robert J
Variation of acharan sulfate and monosaccharide composition and analysis of neutral N-glycans in African giant snail (Achatina fulica).
Glycoconjugate journal 2008;25(9):863-77.
2008: Volpi Nicola; Zhang Zhenqing; Linhardt Robert J
Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers.
Rapid communications in mass spectrometry : RCM 2008;22(22):3526-30.
2008: Park Tae-Joon; Lee Sang-Hyun; Simmons Trevor J; Martin Jeffrey G; Mousa Shaker A; Snezhkova Elisaveta A; Sarnatskaya Veronika V; Nikolaev Vladimir G; Linhardt Robert J
Heparin-cellulose-charcoal composites for drug detoxification prepared using room temperature ionic liquids.
Chemical communications (Cambridge, England) 2008;(40):5022-4.
2008: Zhang Zhenqing; McCallum Scott A; Xie Jin; Nieto Lidia; Corzana Francisco; Jiménez-Barbero Jesús; Chen Miao; Liu Jian; Linhardt Robert J
Solution structures of chemoenzymatically synthesized heparin and its precursors.
Journal of the American Chemical Society 2008;130(39):12998-3007.
2008: Weïwer Michel; Sherwood Trevor; Green Dixy E; Chen Miao; DeAngelis Paul L; Liu Jian; Linhardt Robert J
Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin.
The Journal of organic chemistry 2008;73(19):7631-7.
2008: de Agostini Ariane I; Dong Ji-Cui; de Vantéry Arrighi Corinne; Ramus Marie-Andrée; Dentand-Quadri Isabelle; Thalmann Sébastien; Ventura Patricia; Ibecheole Victoria; Monge Felicia; Fischer Anne-Marie; HajMohammadi Sassan; Shworak Nicholas W; Zhang Lijuan; Zhang Zhenqing; Linhardt Robert J
Human follicular fluid heparan sulfate contains abundant 3-O-sulfated chains with anticoagulant activity.
The Journal of biological chemistry 2008;283(42):28115-24.
2008: Wolff Jeremy J; Laremore Tatiana N; Aslam Hammad; Linhardt Robert J; Amster I Jonathan
Electron-induced dissociation of glycosaminoglycan tetrasaccharides.
Journal of the American Society for Mass Spectrometry 2008;19(10):1449-58.
2008: Varki Ajit P; Baum Linda G; Bellis Susan L; Cummings Richard D; Esko Jeffrey D; Hart Gerald W; Linhardt Robert J; Lowe John B; McEver Rodger P; Srivastava Arun; Sarkar Rita
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
Glycobiology 2008;18(10):747-9.
2008: Zhang Zhenqing; Weïwer Michel; Li Boyangzi; Kemp Melissa M; Daman Tyler H; Linhardt Robert J
Oversulfated chondroitin sulfate: impact of a heparin impurity, associated with adverse clinical events, on low-molecular-weight heparin preparation.
Journal of medicinal chemistry 2008;51(18):5498-501.
2008: Vongchan Preeyanat; Nawarawong Weerasak; Linhardt Robert J
Modification of solid phase red cell adherence assay for the detection of platelet antibodies in patients with thrombocytopenia.
American journal of clinical pathology 2008;130(3):455-66.
2008: Garg Hari G; Mrabat Hicham; Yu Lunyin; Freeman Craig; Li Boyangzi; Zhang Fuming; Linhardt Robert J; Hales Charles A
Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells.
Carbohydrate research 2008;343(14):2406-10.
2008: Volpi Nicola; Maccari Francesca; Linhardt Robert J
Capillary electrophoresis of complex natural polysaccharides.
Electrophoresis 2008;29(15):3095-106.
2008: Nam Jong Hyun; Zhang Fuming; Ermonval Myriam; Linhardt Robert J; Sharfstein Susan T
The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.
Biotechnology and bioengineering 2008;100(6):1178-92.
2008: Park Youmie; Zhang Zhenqing; Linhardt Robert J; Lemosy Ellen K
Distinct heparan sulfate compositions in wild-type and pipe-mutant eggshell matrix.
Fly 2008;2(4):175-9.
2008: Yu Jingjing; Weïwer Michel; Linhardt Robert J; Dordick Jonathan S
The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases.
Current vascular pharmacology 2008;6(3):204-17.
2008: Warda Mohamad; Zhang Fuming; Radwan Moustafa; Zhang Zhenqing; Kim Nari; Kim Young Nam; Linhardt Robert J; Han Jin
Is human placenta proteoglycan remodeling involved in pre-eclampsia?
Glycoconjugate journal 2008;25(5):441-50.
2008: Wolff Jeremy J; Laremore Tatiana N; Busch Alexander M; Linhardt Robert J; Amster I Jonathan
Influence of charge state and sodium cationization on the electron detachment dissociation and infrared multiphoton dissociation of glycosaminoglycan oligosaccharides.
Journal of the American Society for Mass Spectrometry 2008;19(6):790-8.
2008: Guerrini Marco; Beccati Daniela; Shriver Zachary; Naggi Annamaria; Viswanathan Karthik; Bisio Antonella; Capila Ishan; Lansing Jonathan C; Guglieri Sara; Fraser Blair; Al-Hakim Ali; Gunay Nur Sibel; Zhang Zhenqing; Robinson Luke; Buhse Lucinda; Nasr Moheb; Woodcock Janet; Langer Robert; Venkataraman Ganesh; Linhardt Robert J; Casu Benito; Torri Giangiacomo; Sasisekharan Ram
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Nature biotechnology 2008;26(6):669-75.
2008: Copeland Ronald; Balasubramaniam Arun; Tiwari Vaibhav; Zhang Fuming; Bridges Arlene; Linhardt Robert J; Shukla Deepak; Liu Jian
Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1.
Biochemistry 2008;47(21):5774-83.
2008: Bhattacharyya Sumit; Gill Ravinder; Chen Mei Ling; Zhang Fuming; Linhardt Robert J; Dudeja Pradeep K; Tobacman Joanne K
Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells.
The Journal of biological chemistry 2008;283(16):10550-8.
2008: Chi Lianli; Wolff Jeremy J; Laremore Tatiana N; Restaino Odile F; Xie Jin; Schiraldi Chiara; Toida Toshihiko; Amster I Jonathan; Linhardt Robert J
Structural analysis of bikunin glycosaminoglycan.
Journal of the American Chemical Society 2008;130(8):2617-25.
2008: Wolff Jeremy J; Laremore Tatiana N; Busch Alexander M; Linhardt Robert J; Amster I Jonathan
Electron detachment dissociation of dermatan sulfate oligosaccharides.
Journal of the American Society for Mass Spectrometry 2008;19(2):294-304.
2008: Silipo Alba; Zhang Zhenqing; Cañada F Javier; Molinaro Antonio; Linhardt Robert J; Jiménez-Barbero Jesús
Conformational analysis of a dermatan sulfate-derived tetrasaccharide by NMR, molecular modeling, and residual dipolar couplings.
Chembiochem : a European journal of chemical biology 2008;9(2):240-52.
2008: Zhang Zhenqing; Xie Jin; Liu Jian; Linhardt Robert J
Tandem MS can distinguish hyaluronic acid from N-acetylheparosan.
Journal of the American Society for Mass Spectrometry 2008;19(1):82-90.
2008: Murugesan Saravanababu; Xie Jin; Linhardt Robert J
Immobilization of heparin: approaches and applications.
Current topics in medicinal chemistry 2008;8(2):80-100.
2007: Mousa Shaker A; Zhang Fuming; Aljada Ahmad; Chaturvedi Seema; Takieddin Majde; Zhang Haifeng; Chi Lianli; Castelli M Cristina; Friedman Kristen; Goldberg Michael M; Linhardt Robert J
Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects.
Journal of clinical pharmacology 2007;47(12):1508-20.
2007: Zhang Zhenqing; Xie Jin; Zhang Fuming; Linhardt Robert J
Thin-layer chromatography for the analysis of glycosaminoglycan oligosaccharides.
Analytical biochemistry 2007;371(1):118-20.
2007: Eker Bilge; Asuri Prashanth; Murugesan Saravanababu; Linhardt Robert J; Dordick Jonathan S
Enzyme-carbon nanotube conjugates in room-temperature ionic liquids.
Applied biochemistry and biotechnology 2007;143(2):153-63.
2007: Nairn Alison V; Kinoshita-Toyoda Akiko; Toyoda Hidenao; Xie Jin; Harris Kyle; Dalton Stephen; Kulik Michael; Pierce J Michael; Toida Toshihiko; Moremen Kelley W; Linhardt Robert J
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation.
Journal of proteome research 2007;6(11):4374-87.
2007: Vorup-Jensen Thomas; Chi Lianli; Gjelstrup Louise C; Jensen Uffe B; Jewett Craig A; Xie Can; Shimaoka Motomu; Linhardt Robert J; Springer Timothy A
Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin.
The Journal of biological chemistry 2007;282(42):30869-77.
2007: Linhardt Robert J; Kim Jin-Hwan
Combinatorial enzymatic synthesis of heparan sulfate.
Chemistry & biology 2007;14(9):972-3.
2007: Pushparaj Victor L; Shaijumon Manikoth M; Kumar Ashavani; Murugesan Saravanababu; Ci Lijie; Vajtai Robert; Linhardt Robert J; Nalamasu Omkaram; Ajayan Pulickel M
Flexible energy storage devices based on nanocomposite paper.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13574-7.
2007: Sinnis Photini; Coppi Alida; Toida Toshihiko; Toyoda Hidenao; Kinoshita-Toyoda Akiko; Xie Jin; Kemp Melissa M; Linhardt Robert J
Mosquito heparan sulfate and its potential role in malaria infection and transmission.
The Journal of biological chemistry 2007;282(35):25376-84.
2007: Linhardt Robert J; Dordick Jonathan S; Deangelis Paul L; Liu Jian
Enzymatic synthesis of glycosaminoglycan heparin.
Seminars in thrombosis and hemostasis 2007;33(5):453-65.
2007: Sakai Shinobu; Hirano Kana; Toyoda Hidenao; Linhardt Robert J; Toida Toshihiko
Matrix assisted laser desorption ionization-time of flight mass spectrometry analysis of hyaluronan oligosaccharides.
Analytica chimica acta 2007;593(2):207-13.
2007: Du Yuguo; Liu Jun; Linhardt Robert J
Facile synthesis of (+/-)-paeonilide.
The Journal of organic chemistry 2007;72(10):3952-4.
2007: Goetz Regina; Beenken Andrew; Ibrahimi Omar A; Kalinina Juliya; Olsen Shaun K; Eliseenkova Anna V; Xu ChongFeng; Neubert Thomas A; Zhang Fuming; Linhardt Robert J; Yu Xijie; White Kenneth E; Inagaki Takeshi; Kliewer Steven A; Yamamoto Masaya; Kurosu Hiroshi; Ogawa Yasushi; Kuro-o Makoto; Lanske Beate; Razzaque Mohammed S; Mohammadi Moosa
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Molecular and cellular biology 2007;27(9):3417-28.
2007: Yuan Xuejun; Ress Dino K; Linhardt Robert J
Synthesis of nor-C-linked neuraminic acid disaccharide: a versatile precursor of C-analogs of oligosialic acids and gangliosides.
The Journal of organic chemistry 2007;72(8):3085-8.
2007: Zhang Fuming; McLellan Jason S; Ayala Alondra M; Leahy Daniel J; Linhardt Robert J
Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.
Biochemistry 2007;46(13):3933-41.
2007: Murugesan Saravanababu; Mousa Shaker A; O'connor Laura J; Lincoln David W; Linhardt Robert J
Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis.
FEBS letters 2007;581(6):1157-60.
2007: Hrtska Sybil C Lang; Kemp Melissa M; Muñoz Eva M; Azizad Omaira; Banerjee Mani; Raposo Catarina; Kumaran Jyothi; Ghosh Partho; Linhardt Robert J
Investigation of the mechanism of binding between internalin B and heparin using surface plasmon resonance.
Biochemistry 2007;46(10):2697-706.
2007: Kumar Ashavani; Murugesan Saravanababu; Pushparaj Victor; Xie Jin; Soldano Caterina; John George; Nalamasu Omkaram; Ajayan Pulickel M; Linhardt Robert J
Conducting organic-metallic composite submicrometer rods based on ionic liquids.
Small (Weinheim an der Bergstrasse, Germany) 2007;3(3):429-33.
2007: Wolff Jeremy J; Chi Lianli; Linhardt Robert J; Amster I Jonathan
Distinguishing glucuronic from iduronic acid in glycosaminoglycan tetrasaccharides by using electron detachment dissociation.
Analytical chemistry 2007;79(5):2015-22.
2007: Laremore Tatiana N; Zhang Fuming; Linhardt Robert J
Ionic liquid matrix for direct UV-MALDI-TOF-MS analysis of dermatan sulfate and chondroitin sulfate oligosaccharides.
Analytical chemistry 2007;79(4):1604-10.
2007: Park Tae-Joon; Weïwer Michel; Yuan Xuejun; Baytas Sultan N; Munoz Eva M; Murugesan Saravanababu; Linhardt Robert J
Glycosylation in room temperature ionic liquid using unprotected and unactivated donors.
Carbohydrate research 2007;342(3-4):614-20.
2007: Krupa Joanne C; Shaya David; Chi Lianli; Linhardt Robert J; Cygler Miroslaw; Withers Stephen G; Mort John S
Quantitative continuous assay for hyaluronan synthase.
Analytical biochemistry 2007;361(2):218-25.
2007: Wolff Jeremy J; Amster I Jonathan; Chi Lianli; Linhardt Robert J
Electron detachment dissociation of glycosaminoglycan tetrasaccharides.
Journal of the American Society for Mass Spectrometry 2007;18(2):234-44.
2007: Vongchan Preeyanat; Linhardt Robert J
Expression of human liver HSPGs on acute myeloid leukemia.
Clinical immunology (Orlando, Fla.) 2007;122(2):194-206.
2007: Tracy Breca S; Avci Fikri Y; Linhardt Robert J; DeAngelis Paul L
Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans.
The Journal of biological chemistry 2007;282(1):337-44.
2007: Ma Qing; Cornelli Umberto; Hanin Israel; Jeske Walter P; Linhardt Robert J; Walenga Jeanine M; Fareed Jawed; Lee John M
Heparin oligosaccharides as potential therapeutic agents in senile dementia.
Current pharmaceutical design 2007;13(15):1607-16.
2007: Laremore Tatiana N; Linhardt Robert J
Improved matrix-assisted laser desorption/ionization mass spectrometric detection of glycosaminoglycan disaccharides as cesium salts.
Rapid communications in mass spectrometry : RCM 2007;21(7):1315-20.
2007: Ma Qing; Tobu Mahmut; Schultz Christopher; Jeske Walter; Hoppensteadt Debra; Walenga Jeanine; Cornelli Umberto; Lee John; Linhardt Robert; Hanin Israel; Fareed Jawed
Molecular weight dependent tissue factor pathway inhibitor release by heparin and heparin oligosaccharides.
Thrombosis research 2007;119(5):653-61.
2006: Mousa Shaker A; Linhardt Robert; Francis John L; Amirkhosravi Ali
Anti-metastatic effect of a non-anticoagulant low-molecular-weight heparin versus the standard low-molecular-weight heparin, enoxaparin.
Thrombosis and haemostasis 2006;96(6):816-21.
2006: Ha Young Wan; Na Yun-Cheol; Seo Jung-Ju; Kim Soo-Na; Linhardt Robert J; Kim Yeong Shik
Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry.
Journal of chromatography. A 2006;1135(1):27-35.
2006: Warda Mohamad; Toida Toshihiko; Zhang Fuming; Sun Peilong; Munoz Eva; Xie Jin; Linhardt Robert J
Isolation and characterization of heparan sulfate from various murine tissues.
Glycoconjugate journal 2006;23(7-8):555-63.
2006: Barth Heidi; Schnober Eva K; Zhang Fuming; Linhardt Robert J; Depla Erik; Boson Bertrand; Cosset Francois-Loic; Patel Arvind H; Blum Hubert E; Baumert Thomas F
Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction.
Journal of virology 2006;80(21):10579-90.
2006: Garg Hari G; Hales Charles A; Yu Lunyin; Butler Melissa; Islam Tasneem; Xie Jin; Linhardt Robert J
Increase in the growth inhibition of bovine pulmonary artery smooth muscle cells by an O-hexanoyl low-molecular-weight heparin derivative.
Carbohydrate research 2006;341(15):2607-12.
2006: Murugesan Saravanababu; Mousa Shaker; Vijayaraghavan Aravind; Ajayan Pulickel M; Linhardt Robert J
Ionic liquid-derived blood-compatible composite membranes for kidney dialysis.
Journal of biomedical materials research. Part B, Applied biomaterials 2006;79(2):298-304.
2006: Du Yuguo; Chen Qi; Linhardt Robert J
The first total synthesis of sporiolide A.
The Journal of organic chemistry 2006;71(22):8446-51.
2006: Kumar Ashavani; Pushparaj Victor L; Murugesan Saravanababu; Viswanathan Gunaranjan; Nalamasu Rohit; Linhardt Robert J; Nalamasu Omkaram; Ajayan Pulickel M
Synthesis of silica-gold nanocomposites and their porous nanoparticles by an in-situ approach.
Langmuir : the ACS journal of surfaces and colloids 2006;22(21):8631-4.
2006: Shao Chenghua; Zhang Fuming; Kemp Melissa M; Linhardt Robert J; Waisman David M; Head James F; Seaton Barbara A
Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
The Journal of biological chemistry 2006;281(42):31689-95.
2006: Turnbull Jeremy E; Linhardt Robert J
Synthetic sugars enhance the functional glycomics toolkit.
Nature chemical biology 2006;2(9):449-50.
2006: Sakai Shinobu; Akiyama Hiroshi; Sato Yuji; Yoshioka Yasuo; Linhardt Robert J; Goda Yukihiro; Maitani Tamio; Toida Toshihiko
Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice.
The Journal of biological chemistry 2006;281(29):19872-80.
2006: Zhang Fuming; Sun Peilong; Muñoz Eva; Chi Lianli; Sakai Shinobu; Toida Toshihiko; Zhang Haifeng; Mousa Shaker; Linhardt Robert J
Microscale isolation and analysis of heparin from plasma using an anion-exchange spin column.
Analytical biochemistry 2006;353(2):284-6.
2006: Daniels Bruce; Linhardt Robert J; Zhang Fuming; Mao Wenjun; Wice Sandra M; Hiebert Linda M
In vivo antithrombotic synergy of oral heparin and arginine: endothelial thromboresistance without changes in coagulation parameters.
Thrombosis and haemostasis 2006;95(5):865-72.
2006: Chi Lianli; Munoz Eva M; Choi Hyung Seok; Ha Young Wan; Kim Yeong Shik; Toida Toshihiko; Linhardt Robert J
Preparation and structural determination of large oligosaccharides derived from acharan sulfate.
Carbohydrate research 2006;341(7):864-9.
2006: Muñoz Eva; Xu Ding; Kemp Melissa; Zhang Fuming; Liu Jian; Linhardt Robert J
Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate.
Biochemistry 2006;45(16):5122-8.
2006: Murugesan Saravanababu; Park Tae-Joon; Yang Hoichang; Mousa Shaker; Linhardt Robert J
Blood compatible carbon nanotubes--nano-based neoproteoglycans.
Langmuir : the ACS journal of surfaces and colloids 2006;22(8):3461-3.
2006: Laremore Tatiana N; Murugesan Saravanababu; Park Tae-Joon; Avci Fikri Y; Zagorevski Dmitri V; Linhardt Robert J
Matrix-assisted laser desorption/ionization mass spectrometric analysis of uncomplexed highly sulfated oligosaccharides using ionic liquid matrices.
Analytical chemistry 2006;78(6):1774-9.
2006: Suk Ji Young; Zhang Fuming; Balch William E; Linhardt Robert J; Kelly Jeffery W
Heparin accelerates gelsolin amyloidogenesis.
Biochemistry 2006;45(7):2234-42.
2006: Viswanathan Gunaranjan; Murugesan Saravanababu; Pushparaj Victor; Nalamasu Omkaram; Ajayan Pulickel M; Linhardt Robert J
Preparation of biopolymer fibers by electrospinning from room temperature ionic liquids.
Biomacromolecules 2006;7(2):415-8.
2006: Du Yuguo; Liu Jun; Linhardt Robert J
Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B) from D-xylose.
The Journal of organic chemistry 2006;71(3):1251-3.
2006: Olsen Shaun K; Li James Y H; Bromleigh Carrie; Eliseenkova Anna V; Ibrahimi Omar A; Lao Zhimin; Zhang Fuming; Linhardt Robert J; Joyner Alexandra L; Mohammadi Moosa
Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
Genes & development 2006;20(2):185-98.
2006: Muñoz Eva; Xu Ding; Avci Fikri; Kemp Melissa; Liu Jian; Linhardt Robert J
Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions.
Biochemical and biophysical research communications 2006;339(2):597-602.
2006: Warda Mohammad; Linhardt Robert J
Dromedary glycosaminoglycans: molecular characterization of camel lung and liver heparan sulfate.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2006;143(1):37-43.
2006: Toida Toshihiko; Sakai Shinobu; Akiyama Hiroshi; Linhardt Robert J
Immunological activity of chondroitin sulfate.
Advances in pharmacology (San Diego, Calif.) 2006;53():403-15.
2006: Linhardt Robert J; Avci Fikri Y; Toida Toshihiko; Kim Yeong Shik; Cygler Miroslaw
CS lyases: structure, activity, and applications in analysis and the treatment of diseases.
Advances in pharmacology (San Diego, Calif.) 2006;53():187-215.
2005: Chen Jinghua; Avci Fikri Y; Muñoz Eva M; McDowell Lynda M; Chen Miao; Pedersen Lars C; Zhang Lijuan; Linhardt Robert J; Liu Jian
Enzymatic redesigning of biologically active heparan sulfate.
The Journal of biological chemistry 2005;280(52):42817-25.
2005: Yu Haining; Muñoz Eva M; Edens R Erik; Linhardt Robert J
Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance.
Biochimica et biophysica acta 2005;1726(2):168-76.
2005: Yu Xijie; Ibrahimi Omar A; Goetz Regina; Zhang Fuming; Davis Siobhan I; Garringer Holly J; Linhardt Robert J; Ornitz David M; Mohammadi Moosa; White Kenneth E
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.
Endocrinology 2005;146(11):4647-56.
2005: Hirano Kana; Sakai Shinobu; Ishikawa Tsutomu; Avci Fikri Y; Linhardt Robert J; Toida Toshihiko
Preparation of the methyl ester of hyaluronan and its enzymatic degradation.
Carbohydrate research 2005;340(14):2297-304.
2005: Ress Dino K; Baytas Sultan N; Wang Qun; Muñoz Eva M; Tokuzoki Kazuo; Tomiyama Hiroshi; Linhardt Robert J
Synthesis of double C-glycoside analogue of sTn.
The Journal of organic chemistry 2005;70(20):8197-200.
2005: Muñoz Eva M; Yu Haining; Hallock Jeannette; Edens R Erik; Linhardt Robert J
Poly(ethylene glycol)-based biosensor chip to study heparin-protein interactions.
Analytical biochemistry 2005;343(1):176-8.
2005: Sim Joon-Soo; Jun Gyungjin; Toida Toshihiko; Cho So Yean; Choi Don Woong; Chang Seung-Yeup; Linhardt Robert J; Kim Yeong Shik
Quantitative analysis of chondroitin sulfate in raw materials, ophthalmic solutions, soft capsules and liquid preparations.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;818(2):133-9.
2005: Ha Young Wan; Jeon Byong Tae; Moon Sang Ho; Toyoda Hidenao; Toida Toshihiko; Linhardt Robert J; Kim Yeong Shik
Characterization of heparan sulfate from the unossified antler of Cervus elaphus.
Carbohydrate research 2005;340(3):411-6.
2005: Vongchan Preeyanat; Warda Mohamad; Toyoda Hidenao; Toida Toshihiko; Marks Rory M; Linhardt Robert J
Structural characterization of human liver heparan sulfate.
Biochimica et biophysica acta 2005;1721(1-3):1-8.
2005: Ibrahimi Omar A; Yeh Brian K; Eliseenkova Anna V; Zhang Fuming; Olsen Shaun K; Igarashi Makoto; Aaronson Stuart A; Linhardt Robert J; Mohammadi Moosa
Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization.
Molecular and cellular biology 2005;25(2):671-84.
2005: Joo Eun Ji; ten Dam Gerdy B; van Kuppevelt Toin H; Toida Toshihiko; Linhardt Robert J; Kim Yeong Shik
Nucleolin: acharan sulfate-binding protein on the surface of cancer cells.
Glycobiology 2005;15(1):1-9.
2005: Yuan Xuejun; Linhardt Robert J
Recent advances in the synthesis of C-oligosaccharides.
Current topics in medicinal chemistry 2005;5(14):1393-430.
2004: Zhang Fuming; Bries Andrew D; Lang Sybil C; Wang Qun; Murhammer David W; Weiler John M; Linhardt Robert J
Metabolic alteration of the N-glycan structure of a protein from patients with a heterozygous protein deficiency.
Biochimica et biophysica acta 2004;1739(1):43-9.
2004: Baytas Sultan N; Wang Qun; Karst Nathalie A; Dordick Jonathan S; Linhardt Robert J
Solid-phase chemoenzymatic synthesis of C-sialosides.
The Journal of organic chemistry 2004;69(20):6900-3.
2004: Moon Andrea F; Edavettal Suzanne C; Krahn Joe M; Munoz Eva M; Negishi Masahiko; Linhardt Robert J; Liu Jian; Pedersen Lars C
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.
The Journal of biological chemistry 2004;279(43):45185-93.
2004: Ibrahimi Omar A; Zhang Fuming; Eliseenkova Anna V; Itoh Nobuyuki; Linhardt Robert J; Mohammadi Moosa
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.
Human molecular genetics 2004;13(19):2313-24.
2004: Muñoz Eva M; Linhardt Robert J
Heparin-binding domains in vascular biology.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1549-57.
2004: Gu Guofeng; Du Yuguo; Linhardt Robert J
Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.
The Journal of organic chemistry 2004;69(16):5497-500.
2004: Akiyama Hiroshi; Sakai Shinobu; Linhardt Robert J; Goda Yukihiro; Toida Toshihiko; Maitani Tamio
Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin.
The Biochemical journal 2004;382(Pt 1):269-78.
2004: Linhardt Robert J; Toida Toshihiko
Role of glycosaminoglycans in cellular communication.
Accounts of chemical research 2004;37(7):431-8.
2004: Zhang Fuming; Wu Yi; Ma Qing; Hoppensteadt Debra; Fareed Jawed; Linhardt Robert J
Studies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2004;10(3):249-57.
2004: Michel Gurvan; Pojasek Kevin; Li Yunge; Sulea Traian; Linhardt Robert J; Raman Rahul; Prabhakar Vikas; Sasisekharan Ram; Cygler Miroslaw
The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery.
The Journal of biological chemistry 2004;279(31):32882-96.
2004: Edavettal Suzanne C; Lee Karen A; Negishi Masahiko; Linhardt Robert J; Liu Jian; Pedersen Lars C
Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1.
The Journal of biological chemistry 2004;279(24):25789-97.
2004: Linhardt Robert J
Heparin-induced cancer cell death.
Chemistry & biology 2004;11(4):420-2.
2004: Ibrahimi Omar A; Zhang Fuming; Hrstka Sybil C Lang; Mohammadi Moosa; Linhardt Robert J
Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly.
Biochemistry 2004;43(16):4724-30.
2004: Zhang Fuming; Ronca Francesca; Linhardt Robert J; Margolis Richard U
Structural determinants of heparan sulfate interactions with Slit proteins.
Biochemical and biophysical research communications 2004;317(2):352-7.
2004: Du Yuguo; Wei Guohua; Linhardt Robert J
Total synthesis of quercetin 3-sophorotrioside.
The Journal of organic chemistry 2004;69(6):2206-9.
2004: Lunin Vladimir V; Li Yunge; Linhardt Robert J; Miyazono Hirofumi; Kyogashima Mamoru; Kaneko Takuji; Bell Alexander W; Cygler Miroslaw
High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism.
Journal of molecular biology 2004;337(2):367-86.
2004: Peterson Francis C; Elgin E Sonay; Nelson Timothy J; Zhang Fuming; Hoeger Theresa J; Linhardt Robert J; Volkman Brian F
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin.
The Journal of biological chemistry 2004;279(13):12598-604.
2004: Olsen Shaun K; Ibrahimi Omar A; Raucci Angela; Zhang Fuming; Eliseenkova Anna V; Yayon Avner; Basilico Claudio; Linhardt Robert J; Schlessinger Joseph; Mohammadi Moosa
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):935-40.
2004: Ibrahimi Omar A; Zhang Fuming; Eliseenkova Anna V; Linhardt Robert J; Mohammadi Moosa
Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity.
Human molecular genetics 2004;13(1):69-78.
2004: Thanawiroon Charuwan; Rice Kevin G; Toida Toshihiko; Linhardt Robert J
Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides.
The Journal of biological chemistry 2004;279(4):2608-15.
2004: Li Da-Wei; Lee In Sun; Sim Joon-Soo; Toida Toshihiko; Linhardt Robert J; Kim Yeong Shik
Long duration of anticoagulant activity and protective effects of acharan sulfate in vivo.
Thrombosis research 2004;113(1):67-73.
2003: Warda Mohamad; Gouda Eman M; Toida Toshihiko; Chi Lianli; Linhardt Robert J
Isolation and characterization of raw heparin from dromedary intestine: evaluation of a new source of pharmaceutical heparin.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2003;136(4):357-65.
2003: Cho So Yean; Sim Joon-Soo; Kang Sam Sik; Jeong Choon-Sik; Linhardt Robert J; Kim Yeong Shik
Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins.
Archives of pharmacal research 2003;26(12):1102-8.
2003: Karst Nathalie A; Islam Tasneem F; Linhardt Robert J
Sulfo-protected hexosamine monosaccharides: potentially versatile building blocks for glycosaminoglycan synthesis.
Organic letters 2003;5(25):4839-42.
2003: Garg Hari G; Yu Lunyin; Hales Charles A; Toida Toshihiko; Islam Tasneem; Linhardt Robert J
Sulfation patterns in heparin and heparan sulfate: effects on the proliferation of bovine pulmonary artery smooth muscle cells.
Biochimica et biophysica acta 2003;1639(3):225-31.
2003: Gunay Nur Sibel; Linhardt Robert J
Capillary electrophoretic separation of heparin oligosaccharides under conditions amenable to mass spectrometric detection.
Journal of chromatography. A 2003;1014(1-2):225-33.
2003: Thanawiroon Charuwan; Linhardt Robert J
Separation of a complex mixture of heparin-derived oligosaccharides using reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 2003;1014(1-2):215-23.
2003: Du Yuguo; Gu Guofeng; Wei Guohua; Hua Yuxia; Linhardt Robert J
Synthesis of saponins using partially protected glycosyl donors.
Organic letters 2003;5(20):3627-30.
2003: Rathore Dharmendar; Hrstka Sybil C L; Sacci John B; De la Vega Patricia; Linhardt Robert J; Kumar Sanjai; McCutchan Thomas F
Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein.
The Journal of biological chemistry 2003;278(42):40905-10.
2003: Karst Nathalie A; Linhardt Robert J
Recent chemical and enzymatic approaches to the synthesis of glycosaminoglycan oligosaccharides.
Current medicinal chemistry 2003;10(19):1993-2031.
2003: Barth Heidi; Schafer Christiane; Adah Mohammed I; Zhang Fuming; Linhardt Robert J; Toyoda Hidenao; Kinoshita-Toyoda Akiko; Toida Toshihiko; Van Kuppevelt Toin H; Depla Erik; Von Weizsacker Fritz; Blum Hubert E; Baumert Thomas F
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate.
The Journal of biological chemistry 2003;278(42):41003-12.
2003: Avci Fikri Y; Toida Toshihiko; Linhardt Robert J
Chondroitin O-methyl ester: an unusual substrate for chondroitin AC lyase.
Carbohydrate research 2003;338(20):2101-4.
2003: Gunay Nur Sibel; Tadano-Aritomi Keiko; Toida Toshihiko; Ishizuka Ineo; Linhardt Robert J
Evaluation of counterions for electrospray ionization mass spectral analysis of a highly sulfated carbohydrate, sucrose octasulfate.
Analytical chemistry 2003;75(13):3226-31.
2003: Linhardt Robert J
2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.
Journal of medicinal chemistry 2003;46(13):2551-64.
2003: Kuberan Balagurunathan; Sikkander Sulthan A; Tomiyama Hiroshi; Linhardt Robert J
Synthesis of a C-glycoside analogue of sTn: an HIV- and tumor-associated antigen.
Angewandte Chemie (International ed. in English) 2003;42(18):2073-5.
2003: Wang Qun; Dordick Jonathan S; Linhardt Robert J
Chemoenzymatic synthesis of neuraminic acid containing C-glycoside polymers.
Organic letters 2003;5(8):1187-9.
2003: Wang Qun; Linhardt Robert J
Synthesis of a serine-based neuraminic acid C-glycoside.
The Journal of organic chemistry 2003;68(7):2668-72.
2003: Lee Yeon Sil; Yang Hyun Ok; Shin Kuk Hyun; Choi Hyung Seok; Jung Sang Hoon; Kim Yong Man; Oh Deok Kun; Linhardt Robert J; Kim Yeong Shik
Suppression of tumor growth by a new glycosaminoglycan isolated from the African giant snail Achatina fulica.
European journal of pharmacology 2003;465(1-2):191-8.
2003: Polat Tülay; Linhardt Robert J
Zinc triflate-benzoyl bromide: a versatile reagent for the conversion of ether into benzoate protecting groups and ether glycosides into glycosyl bromides.
Carbohydrate research 2003;338(5):447-9.
2003: Warda Mohamad; Mao Wenjun; Toida Toshihiko; Linhardt Robert J
Turkey intestine as a commercial source of heparin? Comparative structural studies of intestinal avian and mammalian glycosaminoglycans.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;134(1):189-97.
2003: Avci Fikri Y; Karst Nathalie A; Linhardt Robert J
Synthetic oligosaccharides as heparin-mimetics displaying anticoagulant properties.
Current pharmaceutical design 2003;9(28):2323-35.
2003: Linhardt Robert J; Toida Toshihiko
Characterization of glycosaminoglycans by capillary electrophoresis.
Methods in molecular biology (Clifton, N.J.) 2003;213():131-44.
2002: Linhardt Robert J; Toida Toshihiko
Tech.Sight. Capillary electrophoresis. Ultra-high resolution separation comes of age.
Science (New York, N.Y.) 2002;298(5597):1441-2.
2002: Garg Hari G; Cindhuchao Naiyaratana; Quinn Deborah A; Hales Charles A; Thanawiroon Charuwan; Capila Ishan; Linhardt Robert J
Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferation.
Carbohydrate research 2002;337(21-23):2359-64.
2002: Islam Tasneem; Butler Melissa; Sikkander Sulthan A; Toida Toshihiko; Linhardt Robert J
Further evidence that periodate cleavage of heparin occurs primarily through the antithrombin binding site.
Carbohydrate research 2002;337(21-23):2239-43.
2002: Yu Guangli; Gunay Nur Sibel; Linhardt Robert J; Toida Toshihiko; Fareed Jawed; Hoppensteadt Debra A; Shadid Hazar; Ferro Vito; Li Caiping; Fewings Kym; Palermo Maria C; Podger Denis
Preparation and anticoagulant activity of the phosphosulfomannan PI-88.
European journal of medicinal chemistry 2002;37(10):783-91.
2002: Yeh Brian K; Eliseenkova Anna V; Plotnikov Alexander N; Green David; Pinnell Jared; Polat Tulay; Gritli-Linde Amel; Linhardt Robert J; Mohammadi Moosa
Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfate.
Molecular and cellular biology 2002;22(20):7184-92.
2002: DeAngelis Paul L; Gunay Nur Sibel; Toida Toshihiko; Mao Wen-jun; Linhardt Robert J
Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively.
Carbohydrate research 2002;337(17):1547-52.
2002: Bürgermeister Jutta; Paper Dietrich H; Vogl Horst; Linhardt Robert J; Franz Gerhard
LaPSvS1, a (1-->3)-beta-galactan sulfate and its effect on angiogenesis in vivo and in vitro.
Carbohydrate research 2002;337(16):1459-66.
2002: Liu Jian; Shriver Zach; Pope R Marshall; Thorp Suzanne C; Duncan Michael B; Copeland Ronald J; Raska Christina S; Yoshida Keiichi; Eisenberg Roselyn J; Cohen Gary; Linhardt Robert J; Sasisekharan Ram
Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D.
The Journal of biological chemistry 2002;277(36):33456-67.
2002: Chaidedgumjorn Amornrut; Suzuki Atsushi; Toyoda Hidenao; Toida Toshihiko; Imanari Toshio; Linhardt Robert J
Conductivity detection for molecular mass estimation of per-O-sulfonated glycosaminoglycans separated by high-performance size-exclusion chromatography.
Journal of chromatography. A 2002;959(1-2):95-102.
2002: Hiebert Linda M; Wice Sandra M; Ping Tidly; Hileman Ronald E; Polat Tfilay; Linhardt Robert J
Tissue distribution of [14C]sucrose octasulfate following oral administration to rats.
Pharmaceutical research 2002;19(6):838-44.
2002: Zhang Fuming; Murhammer David W; Linhardt Robert J
Enzyme kinetics and glycan structural characterization of secreted alkaline phosphatase prepared using the baculovirus expression vector system.
Applied biochemistry and biotechnology 2002;101(3):197-210.
2002: Hernaiz Maria J; LeBrun Laurie A; Wu Yi; Sen Jette W; Linhardt Robert J; Heegaard Niels H H
Characterization of heparin binding by a peptide from amyloid P component using capillary electrophoresis, surface plasmon resonance and isothermal titration calorimetry.
European journal of biochemistry / FEBS 2002;269(12):2860-7.
2002: Bazin Hélène G; Marques Marcos A; Owens Albert P; Linhardt Robert J; Crutcher Keith A
Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides.
Biochemistry 2002;41(25):8203-11.
2002: Capila Ishan; Wu Yi; Rethwisch David W; Matte Allan; Cygler Miroslaw; Linhardt Robert J
Role of arginine 292 in the catalytic activity of chondroitin AC lyase from Flavobacterium heparinum.
Biochimica et biophysica acta 2002;1597(2):260-70.
2002: Zhang Fuming; Fath Melissa; Marks Rory; Linhardt Robert J
A highly stable covalent conjugated heparin biochip for heparin-protein interaction studies.
Analytical biochemistry 2002;304(2):271-3.
2002: van de Westerlo Els M A; Smetsers Toon F C M; Dennissen Michel A B A; Linhardt Robert J; Veerkamp Jacques H; van Muijen Goos N P; van Kuppevelt Toin H
Human single chain antibodies against heparin: selection, characterization, and effect on coagulation.
Blood 2002;99(7):2427-33.
2002: Mao Wenjun; Thanawiroon Charuwan; Linhardt Robert J
Capillary electrophoresis for the analysis of glycosaminoglycans and glycosaminoglycan-derived oligosaccharides.
Biomedical chromatography : BMC 2002;16(2):77-94.
2002: Sakai Shinobu; Onose Jun-ichi; Nakamura Haruka; Toyoda Hidenao; Toida Toshihiko; Imanari Toshio; Linhardt Robert J
Pretreatment procedure for the microdetermination of chondroitin sulfate in plasma and urine.
Analytical biochemistry 2002;302(2):169-74.
2002: Yu Guangli; Guan Huashi; Ioanoviciu Alexandra S; Sikkander Sulthan A; Thanawiroon Charuwan; Tobacman Joanne K; Toida Toshihiko; Linhardt Robert J
Structural studies on kappa-carrageenan derived oligosaccharides.
Carbohydrate research 2002;337(5):433-40.
2002: Capila Ishan; Linhardt Robert J
Heparin-protein interactions.
Angewandte Chemie (International ed. in English) 2002;41(3):391-412.
2002: Ma Qing; Dudas Bertalan; Daud Asif; Iqbal Omer; Hoppensteadt Debra; Jeske Walter; Cornelli Umberto; Lee John; Lorens Stanley; Mervis Ronald; Hanin Israel; Capila Ishan; Linhardt Robert; Fareed Jawed
Molecular and biochemical profiling of a heparin-derived oligosaccharide, C3.
Thrombosis research 2002;105(4):303-9.
2002: Cho So Yean; Kim Jong Sik; Li Hong; Shim Changkoo; Linhardt Robert J; Kim Yeong Shik
Enhancement of paracellular transport of heparin disaccharide across Caco-2 cell monolayers.
Archives of pharmacal research 2002;25(1):86-92.
2002: Ferro Vito; Li Caiping; Fewings Kym; Palermo Maria C; Linhardt Robert J; Toida Toshihiko
Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.
Carbohydrate research 2002;337(2):139-46.
2002: Zhang Fuming; Saarinen Mark A; Itle Laura J; Lang Sybil C; Murhammer David W; Linhardt Robert J
The effect of dissolved oxygen (DO) concentration on the glycosylation of recombinant protein produced by the insect cell-baculovirus expression system.
Biotechnology and bioengineering 2002;77(2):219-24.
2001: Ye S; Luo Y; Lu W; Jones R B; Linhardt R J; Capila I; Toida T; Kan M; Pelletier H; McKeehan W L
Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry 2001;40(48):14429-39.
2001: Jeong J; Toida T; Muneta Y; Kosiishi I; Imanari T; Linhardt R J; Choi H S; Wu S J; Kim Y S
Localization and characterization of acharan sulfate in the body of the giant African snail Achatina fulica.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;130(4):513-9.
2001: Libeu C P; Lund-Katz S; Phillips M C; Wehrli S; Hernáiz M J; Capila I; Linhardt R J; Raffaï R L; Newhouse Y M; Zhou F; Weisgraber K H
New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.
The Journal of biological chemistry 2001;276(42):39138-44.
2001: Rathore D; McCutchan T F; Garboczi D N; Toida T; Hernáiz M J; LeBrun L A; Lang S C; Linhardt R J
Direct measurement of the interactions of glycosaminoglycans and a heparin decasaccharide with the malaria circumsporozoite protein.
Biochemistry 2001;40(38):11518-24.
2001: Wolff M W; Zhang F; Roberg J J; Caldwell E E; Kaul P R; Serrahn J N; Murhammer D W; Linhardt R J; Weiler J M
Expression of C1 esterase inhibitor by the baculovirus expression vector system: preparation, purification, and characterization.
Protein expression and purification 2001;22(3):414-21.
2001: Edens R E; LeBrun L A; Linhardt R J; Kaul P R; Weiler J M
Certain high molecular weight heparin chains have high affinity for vitronectin.
Archives of biochemistry and biophysics 2001;391(2):278-85.
2001: Marks R M; Lu H; Sundaresan R; Toida T; Suzuki A; Imanari T; Hernáiz M J; Linhardt R J
Probing the interaction of dengue virus envelope protein with heparin: assessment of glycosaminoglycan-derived inhibitors.
Journal of medicinal chemistry 2001;44(13):2178-87.
2001: Linhardt R J
Analysis of glycosaminoglycans with polysaccharide lyases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 17():Unit17.13B.
2001: Dong J; Peters-Libeu C A; Weisgraber K H; Segelke B W; Rupp B; Capila I; Hernáiz M J; LeBrun L A; Linhardt R J
Interaction of the N-terminal domain of apolipoprotein E4 with heparin.
Biochemistry 2001;40(9):2826-34.
2001: Huang W; Boju L; Tkalec L; Su H; Yang H O; Gunay N S; Linhardt R J; Kim Y S; Matte A; Cygler M
Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
Biochemistry 2001;40(8):2359-72.
2001: Zhang F; Wolff M W; Williams D; Busch K; Lang S C; Murhammer D W; Linhardt R J
Affinity purification of secreted alkaline phosphatase produced by baculovirus expression vector system.
Applied biochemistry and biotechnology 2001;90(2):125-36.
2001: Capila I; Hernáiz M J; Mo Y D; Mealy T R; Campos B; Dedman J R; Linhardt R J; Seaton B A
Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Structure (London, England : 1993) 2001;9(1):57-64.
2001: Koketsu M; Linhardt R J
X-ray diffraction and high-resolution NMR spectroscopic analysis of 2,4,7,8-tetra-O-acetyl-3-deoxy-alpha-D-manno-2-octulopyranosono-1,5-lactone.
Carbohydrate research 2001;330(1):145-7.
2001: Hernáiz M J; Linhardt R J
Degradation of chondroitin sulfate and dermatan sulfate with chondroitin lyases.
Methods in molecular biology (Clifton, N.J.) 2001;171():363-71.
2001: LeBrun L A; Linhardt R J
Degradation of heparan sulfate with heparin lyases.
Methods in molecular biology (Clifton, N.J.) 2001;171():353-61.
2000: Dasgupta F; Masada R I; Starr C M; Kuberan B; Yang H O; Linhardt R J
Chemoenzymatic preparation of dermatan sulfate oligosaccharides as arylsulfatase B and alpha-L-iduronidase substrates.
Glycoconjugate journal 2000;17(12):829-34.
2000: Yu G; LeBrun L; Gunay N S; Hoppensteadt D; Walenga J M; Fareed J; Linhardt R J
Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.
Thrombosis research 2000;100(6):549-56.
2000: Choe J; Zhang F; Wolff M W; Murhammer D W; Linhardt R J; Dordick J S
Separation of alpha-acid glycoprotein glycoforms using affinity-based reversed micellar extraction and separation.
Biotechnology and bioengineering 2000;70(5):484-90.
2000: Yang H O; Gunay N S; Toida T; Kuberan B; Yu G; Kim Y S; Linhardt R J
Preparation and structural determination of dermatan sulfate-derived oligosaccharides.
Glycobiology 2000;10(10):1033-9.
2000: Koketsu M; Kuberan B; Linhardt R J
Stereoselective synthesis of the alpha-glycoside of a KDO "C"-disaccharide.
Organic letters 2000;2(21):3361-3.
2000: Schlessinger J; Plotnikov A N; Ibrahimi O A; Eliseenkova A V; Yeh B K; Yayon A; Linhardt R J; Mohammadi M
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Molecular cell 2000;6(3):743-50.
2000: Hernaiz M; Liu J; Rosenberg R D; Linhardt R J
Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III.
Biochemical and biophysical research communications 2000;276(1):292-7.
2000: Koketsu M; Linhardt R J
Electrophoresis for the analysis of acidic oligosaccharides.
Analytical biochemistry 2000;283(2):136-45.
2000: Wang Q; Wolff M; Polat T; Du Y; Linhardt R J
Inhibition of neuraminidase with neuraminic acid C-glycosides.
Bioorganic & medicinal chemistry letters 2000;10(9):941-4.
2000: Kilpelainen I; Kaksonen M; Kinnunen T; Avikainen H; Fath M; Linhardt R J; Raulo E; Rauvala H
Heparin-binding growth-associated molecule contains two heparin-binding beta -sheet domains that are homologous to the thrombospondin type I repeat.
The Journal of biological chemistry 2000;275(18):13564-70.
2000: Hiebert L M; Wice S M; Ping T; Hileman R E; Capila I; Linhardt R J
Tissue distribution and antithrombotic activity of unlabeled or 14C-labeled porcine intestinal mucosal heparin following administration to rats by the oral route.
Canadian journal of physiology and pharmacology 2000;78(4):307-20.
1999: Wolff M W; Murhammer D W; Jarvis D L; Linhardt R J
Electrophoretic analysis of glycoprotein glycans produced by lepidopteran insect cells infected with an immediate early recombinant baculovirus encoding mammalian beta1,4-galactosyltransferase.
Glycoconjugate journal 1999;16(12):753-6.
1999: Huang W; Matte A; Li Y; Kim Y S; Linhardt R J; Su H; Cygler M
Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution.
Journal of molecular biology 1999;294(5):1257-69.
1999: Park Y; Yu G; Gunay N S; Linhardt R J
Purification and characterization of heparan sulphate proteoglycan from bovine brain.
The Biochemical journal 1999;344 Pt 3():723-30.
1999: Toida T; Maruyama T; Ogita Y; Suzuki A; Toyoda H; Imanari T; Linhardt R J
Preparation and anticoagulant activity of fully O-sulphonated glycosaminoglycans.
International journal of biological macromolecules 1999;26(4):233-41.
1999: Garg H G; Joseph P A; Thompson B T; Hales C A; Toida T; Imanari T; Capila I; Linhardt R J
Effect of fully sulfated glycosaminoglycans on pulmonary artery smooth muscle cell proliferation.
Archives of biochemistry and biophysics 1999;371(2):228-33.
1999: Amornrut C; Toida T; Imanari T; Woo E R; Park H; Linhardt R; Wu S J; Kim Y S
A new sulfated beta-galactan from clams with anti-HIV activity.
Carbohydrate research 1999;321(1-2):121-7.
1999: Fath M; VanderNoot V; Kilpeläinen I; Kinnunen T; Rauvala H; Linhardt R J
Interaction of soluble and surface-bound heparin binding growth-associated molecule with heparin.
FEBS letters 1999;454(1-2):105-8.
1999: Kuberan B; Gunay N S; Dordick J S; Linhardt R J
Preparation and isolation of neoglycoconjugates using biotin-streptavidin complexes.
Glycoconjugate journal 1999;16(6):271-81.
1999: Gunay N S; Linhardt R J
Heparinoids: structure, biological activities and therapeutic applications.
Planta medica 1999;65(4):301-6.
1999: Capila I; VanderNoot V A; Mealy T R; Seaton B A; Linhardt R J
Interaction of heparin with annexin V.
FEBS letters 1999;446(2-3):327-30.
1999: Wolff M W; Murhammer D W; Linhardt R J
Release and preparation of intact and unreduced N-linked oligosaccharides from Sf-9 insect cells.
Preparative biochemistry & biotechnology 1999;29(1):1-21.
1999: Caldwell E E; Andreasen A M; Blietz M A; Serrahn J N; VanderNoot V; Park Y; Yu G; Linhardt R J; Weiler J M
Heparin binding and augmentation of C1 inhibitor activity.
Archives of biochemistry and biophysics 1999;361(2):215-22.
1999: Linhardt R J; Gunay N S
Production and chemical processing of low molecular weight heparins.
Seminars in thrombosis and hemostasis 1999;25 Suppl 3():5-16.
1998: Wu S J; Chun M W; Shin K H; Toida T; Park Y; Linhardt R J; Kim Y S
Chemical sulfonation and anticoagulant activity of acharan sulfate.
Thrombosis research 1998;92(6):273-81.
1998: Hileman R E; Siegel M M; Tabei K; Balagurunathan K; Linhardt R J
Isolation and characterization of beta-cyclodextrin sulfates by preparative gradient polyacrylamide gel electrophoresis, capillary electrophoresis and electrospray ionization - mass spectrometry.
Electrophoresis 1998;19(15):2677-81.
1998: Wu X; Linhardt R J
Capillary affinity chromatography and affinity capillary electrophoresis of heparin binding proteins.
Electrophoresis 1998;19(15):2650-3.
1998: Hileman R E; Jennings R N; Linhardt R J
Thermodynamic analysis of the heparin interaction with a basic cyclic peptide using isothermal titration calorimetry.
Biochemistry 1998;37(43):15231-7.
1998: Kim Y S; Ahn M Y; Wu S J; Kim D H; Toida T; Teesch L M; Park Y; Yu G; Lin J; Linhardt R J
Determination of the structure of oligosaccharides prepared from acharan sulfate.
Glycobiology 1998;8(9):869-77.
1998: Bazin H G; Capila I; Linhardt R J
Conformational study of synthetic delta 4-uronate monosaccharides and glycosaminoglycan-derived disaccharides.
Carbohydrate research 1998;309(2):135-44.
1998: Ahn M Y; Shin K H; Kim D H; Jung E A; Toida T; Linhardt R J; Kim Y S
Characterization of a Bacteroides species from human intestine that degrades glycosaminoglycans.
Canadian journal of microbiology 1998;44(5):423-9.
1998: Fath M A; Wu X; Hileman R E; Linhardt R J; Kashem M A; Nelson R M; Wright C D; Abraham W M
Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma.
The Journal of biological chemistry 1998;273(22):13563-9.
1998: Wu X; Loganathan D; Linhardt R J
Sensitive method for the quantification of beta-glucuronidase activity in human urine using capillary electrophoresis with fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1998;708(1-2):61-6.
1998: VanderNoot V A; Hileman R E; Dordick J S; Linhardt R J
Affinity capillary electrophoresis employing immobilized glycosaminoglycan to resolve heparin-binding peptides.
Electrophoresis 1998;19(3):437-41.
1998: Hileman R E; Fromm J R; Weiler J M; Linhardt R J
Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(2):156-67.
1998: Maruyama T; Toida T; Imanari T; Yu G; Linhardt R J
Conformational changes and anticoagulant activity of chondroitin sulfate following its O-sulfonation.
Carbohydrate research 1998;306(1-2):35-43.
1997: Toida T; Shima M; Azumaya S; Maruyama T; Toyoda H; Imanari T; Linhardt R J
Detection of glycosaminoglycans as a copper(II) complex in high-performance liquid chromatography.
Journal of chromatography. A 1997;787(1-2):266-70.
1997: Fromm J R; Hileman R E; Weiler J M; Linhardt R J
Interaction of fibroblast growth factor-1 and related peptides with heparan sulfate and its oligosaccharides.
Archives of biochemistry and biophysics 1997;346(2):252-62.
1997: Toida T; Huang Y; Washio Y; Maruyama T; Toyoda H; Imanari T; Linhardt R J
Chemical microdetermination of heparin in plasma.
Analytical biochemistry 1997;251(2):219-26.
1997: Nadkarni V D; Linhardt R J
Directional immobilization of heparin onto the nonporous surface of polystyrene microplates.
BioTechniques 1997;23(3):382-5.
1997: Chen Y; Maguire T; Hileman R E; Fromm J R; Esko J D; Linhardt R J; Marks R M
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate.
Nature medicine 1997;3(8):866-71.
1997: Choe J; VanderNoot V A; Linhardt R J; Dordick J S
Parameters affecting the efficiency of affinity-based reversed micellar extraction and separation (ARMES) in glycoprotein purification.
Biotechnology progress 1997;13(4):440-5.
1997: Siegel M M; Tabei K; Kagan M Z; Vlahov I R; Hileman R E; Linhardt R J
Polysulfated carbohydrates analyzed as ion-paired complexes with basic peptides and proteins using electrospray negative ionization mass spectrometry.
Journal of mass spectrometry : JMS 1997;32(7):760-72.
1997: Fromm J R; Hileman R E; Caldwell E E; Weiler J M; Linhardt R J
Pattern and spacing of basic amino acids in heparin binding sites.
Archives of biochemistry and biophysics 1997;343(1):92-100.
1997: Wang H; Toida T; Kim Y S; Capila I; Hileman R E; Bernfield M; Linhardt R J
Glycosaminoglycans can influence fibroblast growth factor-2 mitogenicity without significant growth factor binding.
Biochemical and biophysical research communications 1997;235(2):369-73.
1997: Hileman R E; Smith A E; Toida T; Linhardt R J
Preparation and structure of heparin lyase-derived heparan sulfate oligosaccharides.
Glycobiology 1997;7(2):231-9.
1997: Toida T; Yoshida H; Toyoda H; Koshiishi I; Imanari T; Hileman R E; Fromm J R; Linhardt R J
Structural differences and the presence of unsubstituted amino groups in heparan sulphates from different tissues and species.
The Biochemical journal 1997;322 ( Pt 2)():499-506.
1997: Park Y; Cho S; Linhardt R J
Exploration of the action pattern of Streptomyces hyaluronate lyase using high-resolution capillary electrophoresis.
Biochimica et biophysica acta 1997;1337(2):217-26.
1997: Dougher A M; Wasserstrom H; Torley L; Shridaran L; Westdock P; Hileman R E; Fromm J R; Anderberg R; Lyman S; Linhardt R J; Kaplan J; Terman B I
Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor.
Growth factors (Chur, Switzerland) 1997;14(4):257-68.
1996: Toida T; Hileman R E; Smith A E; Vlahova P I; Linhardt R J
Enzymatic preparation of heparin oligosaccharides containing antithrombin III binding sites.
The Journal of biological chemistry 1996;271(50):32040-7.
1996: Nadkarni V D; Toida T; Van Gorp C L; Schubert R L; Weiler J M; Hansen K P; Caldwell E E; Linhardt R J
Preparation and biological activity of N-sulfonated chondroitin and dermatan sulfate derivatives.
Carbohydrate research 1996;290(1):87-96.
1996: Mikhailov D; Mayo K H; Vlahov I R; Toida T; Pervin A; Linhardt R J
NMR solution conformation of heparin-derived tetrasaccharide.
The Biochemical journal 1996;318 ( Pt 1)():93-102.
1996: Kim Y S; Jo Y Y; Chang I M; Toida T; Park Y; Linhardt R J
A new glycosaminoglycan from the giant African snail Achatina fulica.
The Journal of biological chemistry 1996;271(20):11750-5.
1996: Mikhailov D; Mayo K H; Pervin A; Linhardt R J
13C-NMR relation study of heparin-disaccharide interactions with tripeptides GRG and GKG.
The Biochemical journal 1996;315 ( Pt 2)():447-54.
1996: Toida T; Linhardt R J
Detection of glycosaminoglycans as a copper (II) complex in capillary electrophoresis.
Electrophoresis 1996;17(2):341-6.
1996: Caldwell E E; Nadkarni V D; Fromm J R; Linhardt R J; Weiler J M
Importance of specific amino acids in protein binding sites for heparin and heparan sulfate.
The international journal of biochemistry & cell biology 1996;28(2):203-16.
1996: Jandik K A; Kruep D; Cartier M; Linhardt R J
Accelerated stability studies of heparin.
Journal of pharmaceutical sciences 1996;85(1):45-51.
1996: Linhardt R J; Pervin A
Separation of negatively charged carbohydrates by capillary electrophoresis.
Journal of chromatography. A 1996;720(1-2):323-35.
1995: Liu J; Desai U R; Han X J; Toida T; Linhardt R J
Strategy for the sequence analysis of heparin.
Glycobiology 1995;5(8):765-74.
1995: Gu K; Linhardt R J; Laliberté M; Gu K; Zimmermann J
Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum.
The Biochemical journal 1995;312 ( Pt 2)():569-77.
1995: Fromm J R; Hileman R E; Caldwell E E; Weiler J M; Linhardt R J
Differences in the interaction of heparin with arginine and lysine and the importance of these basic amino acids in the binding of heparin to acidic fibroblast growth factor.
Archives of biochemistry and biophysics 1995;323(2):279-87.
1995: Griffin C C; Linhardt R J; Van Gorp C L; Toida T; Hileman R E; Schubert R L; Brown S E
Isolation and characterization of heparan sulfate from crude porcine intestinal mucosal peptidoglycan heparin.
Carbohydrate research 1995;276(1):183-97.
1995: Desai U R; Vlahov I R; Pervin A; Linhardt R J
Conformational analysis of sucrose octasulfate by high resolution nuclear magnetic resonance spectroscopy.
Carbohydrate research 1995;275(2):391-401.
1995: Kerns R J; Linhardt R J
Separation of hydroxyl protected heparin derived disaccharides using reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 1995;705(2):369-73.
1995: Linhardt R J; Han X J; Fromm J R
Lectin affinity electrophoresis.
Molecular biotechnology 1995;3(3):191-7.
1995: Linhardt R J; Hileman R E
Dermatan sulfate as a potential therapeutic agent.
General pharmacology 1995;26(3):443-51.
1995: Nadkarni V D; Linhardt R J
Modified assay for the measurement of biotin in the presence of heparin.
Analytical biochemistry 1995;227(2):402-4.
1995: Kim Y S; Liu J; Han X J; Pervin A; Linhardt R J
Analysis of fluorescently labeled sugars by reversed-phase ion-pairing high-performance liquid chromatography.
Journal of chromatographic science 1995;33(4):162-7.
1995: Edens R E; Fromm J R; Fromm S J; Linhardt R J; Weiler J M
Two-dimensional affinity resolution electrophoresis demonstrates that three distinct heparin populations interact with antithrombin III.
Biochemistry 1995;34(8):2400-7.
1995: Pervin A; Gallo C; Jandik K A; Han X J; Linhardt R J
Preparation and structural characterization of large heparin-derived oligosaccharides.
Glycobiology 1995;5(1):83-95.
1995: Desai U R; Linhardt R J
Molecular weight of heparin using 13C nuclear magnetic resonance spectroscopy.
Journal of pharmaceutical sciences 1995;84(2):212-5.
1995: Kerns R J; Vlahov I R; Linhardt R J
Capillary electrophoresis for monitoring chemical reactions: sulfation and synthetic manipulation of sulfated carbohydrates.
Carbohydrate research 1995;267(1):143-52.
1994: Nadkarni V D; Pervin A; Linhardt R J
Directional immobilization of heparin onto beaded supports.
Analytical biochemistry 1994;222(1):59-67.
1994: Pervin A; al-Hakim A; Linhardt R J
Separation of glycosaminoglycan-derived oligosaccharides by capillary electrophoresis using reverse polarity.
Analytical biochemistry 1994;221(1):182-8.
1994: Bae J; Desai U R; Pervin A; Caldwell E E; Weiler J M; Linhardt R J
Interaction of heparin with synthetic antithrombin III peptide analogues.
The Biochemical journal 1994;301 ( Pt 1)():121-9.
1994: Liu J; Pervin A; Gallo C M; Desai U R; Van Gorp C L; Linhardt R J
New approaches for the preparation of hydrophobic heparin derivatives.
Journal of pharmaceutical sciences 1994;83(7):1034-9.
1994: Jandik K A; Gu K; Linhardt R J
Action pattern of polysaccharide lyases on glycosaminoglycans.
Glycobiology 1994;4(3):289-96.
1994: Desai U R; Linhardt R J
Molecular weight of low molecular weight heparins by 13C nuclear magnetic resonance spectroscopy.
Carbohydrate research 1994;255():193-212.
1994: Linhardt R J; Desai U R; Liu J; Pervin A; Hoppensteadt D; Fareed J
Low molecular weight dermatan sulfate as an antithrombotic agent. Structure-activity relationship studies.
Biochemical pharmacology 1994;47(7):1241-52.
1994: Edens R E; Linhardt R J; Bell C S; Weiler J M
Heparin and derivatized heparin inhibit zymosan and cobra venom factor activation of complement in serum.
Immunopharmacology 1994;27(2):145-53.
1994: Linhardt R J
Capillary electrophoresis of oligosaccharides.
Methods in enzymology 1994;230():265-80.
1993: Desai U R; Wang H M; Linhardt R J
Substrate specificity of the heparin lyases from Flavobacterium heparinum.
Archives of biochemistry and biophysics 1993;306(2):461-8.
1993: Desai U R; Wang H M; Linhardt R J
Specificity studies on the heparin lyases from Flavobacterium heparinum.
Biochemistry 1993;32(32):8140-5.
1993: Desai U R; Wang H; Ampofo S A; Linhardt R J
Oligosaccharide composition of heparin and low-molecular-weight heparins by capillary electrophoresis.
Analytical biochemistry 1993;213(1):120-7.
1993: Gu K; Liu J; Pervin A; Linhardt R J
Comparison of the activity of two chondroitin AC lyases on dermatan sulfate.
Carbohydrate research 1993;244(2):369-77.
1993: Desai U R; Wang H M; Kelly T R; Linhardt R J
Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin.
Carbohydrate research 1993;241():249-59.
1993: Gu K; Edens R E; Jandik K A; Linhardt R J
Monoclonal antibodies prepared against heparin lyase I and their reactivity toward heparin lyase I, II and III.
The International journal of biochemistry 1993;25(3):331-6.
1993: Schmitt E A; Flanagan D R; Linhardt R J
Degradation and release properties of pellets fabricated from three commercial poly(D,L-lactide-co-glycolide) biodegradable polymers.
Journal of pharmaceutical sciences 1993;82(3):326-9.
1993: Pervin A; Gu K; Linhardt R J
Capillary electrophoresis to measure sulfoesterase activity on chondroitin sulfate and heparin derived disaccharides.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society 1993;3(6):297-303.
1992: Linhardt R J; Ampofo S A; Fareed J; Hoppensteadt D; Mulliken J B; Folkman J
Isolation and characterization of human heparin.
Biochemistry 1992;31(49):12441-5.
1992: Lohse D L; Linhardt R J
Purification and characterization of heparin lyases from Flavobacterium heparinum.
The Journal of biological chemistry 1992;267(34):24347-55.
1992: Lee K B; Desai U R; Palcic M M; Hindsgaul O; Linhardt R J
An electrophoresis-based assay for glycosyltransferase activity.
Analytical biochemistry 1992;205(1):108-14.
1992: Edens R E; al-Hakim A; Weiler J M; Rethwisch D G; Fareed J; Linhardt R J
Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular-weight heparin derivatives.
Journal of pharmaceutical sciences 1992;81(8):823-7.
1992: Lee K B; Kim Y S; Linhardt R J
Lectin affinity electrophoresis for the separation of fluorescently labeled sugar derivatives.
Analytical biochemistry 1992;203(2):206-10.
1992: Weiler J M; Edens R E; Linhardt R J; Kapelanski D P
Heparin and modified heparin inhibit complement activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3210-5.
1992: Linhardt R J; Wang H M; Loganathan D; Bae J H
Search for the heparin antithrombin III-binding site precursor.
The Journal of biological chemistry 1992;267(4):2380-7.
1992: Linhardt R J; Wang H M; Loganathan D; Lamb D J; Mallis L M
Analysis of glycosaminoglycan-derived oligosaccharides using fast-atom-bombardment mass-spectrometry.
Carbohydrate research 1992;225(1):137-45.
1992: Linhardt R J; Wang H M; Ampofo S A
New methodologies in heparin structure analysis and the generation of LMW heparins.
Advances in experimental medicine and biology 1992;313():37-47.
1991: Ampofo S A; Wang H M; Linhardt R J
Disaccharide compositional analysis of heparin and heparan sulfate using capillary zone electrophoresis.
Analytical biochemistry 1991;199(2):249-55.
1991: Linhardt R J; al-Hakim A; Liu J A; Hoppensteadt D; Mascellani G; Bianchini P; Fareed J
Structural features of dermatan sulfates and their relationship to anticoagulant and antithrombotic activities.
Biochemical pharmacology 1991;42(8):1609-19.
1991: Wang H M; Loganathan D; Linhardt R J
Determination of the pKa of glucuronic acid and the carboxy groups of heparin by 13C-nuclear-magnetic-resonance spectroscopy.
The Biochemical journal 1991;278 ( Pt 3)():689-95.
1991: Lee K B; Kim Y S; Linhardt R J
Capillary zone electrophoresis for the quantitation of oligosaccharides formed through the action of chitinase.
Electrophoresis 1991;12(9):636-40.
1991: Lee K B; al-Hakim A; Loganathan D; Linhardt R J
A new method for sequencing linear oligosaccharides on gels using charged, fluorescent conjugates.
Carbohydrate research 1991;214(1):155-68.
1991: al-Hakim A; Linhardt R J
Capillary electrophoresis for the analysis of chondroitin sulfate- and dermatan sulfate-derived disaccharides.
Analytical biochemistry 1991;195(1):68-73.
1991: Linhardt R J; al-Hakim A; Liu S Y; Kim Y S; Fareed J
Molecular profile and mapping of dermatan sulfates from different origins.
Seminars in thrombosis and hemostasis 1991;17 Suppl 1():15-22.
1991: al-Hakim A; Linhardt R J
Electrophoresis and detection of nanogram quantities of exogenous and endogenous glycosaminoglycans in biological fluids.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society 1991;1(6):305-12.
1990: Gordon D L; Linhardt R; Adams H P
Low-molecular-weight heparins and heparinoids and their use in acute or progressing ischemic stroke.
Clinical neuropharmacology 1990;13(6):522-43.
1990: Edens R E; Linhardt R J; Weiler J M
Immobilization of C3b with retention of functional activity.
Journal of immunological methods 1990;133(1):67-70.
1990: Linhardt R J; Loganathan D; al-Hakim A; Wang H M; Walenga J M; Hoppensteadt D; Fareed J
Oligosaccharide mapping of low molecular weight heparins: structure and activity differences.
Journal of medicinal chemistry 1990;33(6):1639-45.
1990: Loganathan D; Wang H M; Mallis L M; Linhardt R J
Structural variation in the antithrombin III binding site region and its occurrence in heparin from different sources.
Biochemistry 1990;29(18):4362-8.
1990: Linhardt R J; Turnbull J E; Wang H M; Loganathan D; Gallagher J T
Examination of the substrate specificity of heparin and heparan sulfate lyases.
Biochemistry 1990;29(10):2611-7.
1990: Linhardt R J; Baenziger N C; Ronsen B
Structure of amiprilose hydrochloride, a novel anti-inflammatory agent.
Journal of pharmaceutical sciences 1990;79(2):158-62.
1990: Lee K B; Loganathan D; Merchant Z M; Linhardt R J
Carbohydrate analysis of glycoproteins. A review.
Applied biochemistry and biotechnology 1990;23(1):53-80.
1990: al-Hakim A; Linhardt R J
Isolation and recovery of acidic oligosaccharides from polyacrylamide gels by semi-dry electrotransfer.
Electrophoresis 1990;11(1):23-8.
1990: Cohen D M; Linhardt R J
Randomness in the heparin polymer: computer simulations of alternative action patterns of heparin lyase.
Biopolymers 1990;30(7-8):733-41.
1989: Linhardt R J; Gu K N; Loganathan D; Carter S R
Analysis of glycosaminoglycan-derived oligosaccharides using reversed-phase ion-pairing and ion-exchange chromatography with suppressed conductivity detection.
Analytical biochemistry 1989;181(2):288-96.
1989: Rice K G; Linhardt R J
Study of structurally defined oligosaccharide substrates of heparin and heparan monosulfate lyases.
Carbohydrate research 1989;190(2):219-33.
1989: Linhardt R J; Cohen D M; Rice K G
Nonrandom structural features in the heparin polymer.
Biochemistry 1989;28(7):2888-94.
1989: Weiler J M; Linhardt R J
Comparison of the activity of polyanions and polycations on the classical and alternative pathways of complement.
Immunopharmacology 1989;17(2):65-72.
1989: Biller J; Massey E W; Marler J R; Adams H P; Davis J N; Bruno A; Henriksen R A; Linhardt R J; Goldstein L B; Alberts M
A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke.
Neurology 1989;39(2 Pt 1):262-5.
1989: Kim Y S; Linhardt R J
Structural features of heparin and their effect on heparin cofactor II mediated inhibition of thrombin.
Thrombosis research 1989;53(1):55-71.
1988: Linhardt R J; Rice K G; Kim Y S; Engelken J D; Weiler J M
Homogeneous, structurally defined heparin-oligosaccharides with low anticoagulant activity inhibit the generation of the amplification pathway C3 convertase in vitro.
The Journal of biological chemistry 1988;263(26):13090-6.
1988: Linhardt R J; Rice K G; Kim Y S; Lohse D L; Wang H M; Loganathan D
Mapping and quantification of the major oligosaccharide components of heparin.
The Biochemical journal 1988;254(3):781-7.
1988: Kim Y S; Lee K B; Linhardt R J
Microheterogeneity of plasma glycoproteins heparin cofactor II and antithrombin III and their carbohydrate analysis.
Thrombosis research 1988;51(1):97-104.
1987: Linhardt R J
Bioassays. Patents and literature.
Applied biochemistry and biotechnology 1987;15(3):279-95.
1987: Linhardt R J
Monoclonal antibodies and immobilized antibodies. Patents and literature.
Applied biochemistry and biotechnology 1987;15(1):53-80.
1987: Rice K G; Rottink M K; Linhardt R J
Fractionation of heparin-derived oligosaccharides by gradient polyacrylamide-gel electrophoresis.
The Biochemical journal 1987;244(3):515-22.
1987: Linhardt R J; Langer R
New approaches for anticoagulation in extracorporeal therapy.
Biomaterials, artificial cells, and artificial organs 1987;15(1):91-100.
1986: Linhardt R J; Rice K G; Merchant Z M; Kim Y S; Lohse D L
Structure and activity of a unique heparin-derived hexasaccharide.
The Journal of biological chemistry 1986;261(31):14448-54.
1985: Linhardt R J; Merchant Z M; Rice K G; Kim Y S; Fitzgerald G L; Grant A C; Langer R
Evidence of random structural features in the heparin polymer.
Biochemistry 1985;24(26):7805-10.
1985: Rice K G; Kim Y S; Grant A C; Merchant Z M; Linhardt R J
High-performance liquid chromatographic separation of heparin-derived oligosaccharides.
Analytical biochemistry 1985;150(2):325-31.
1985: Merchant Z M; Kim Y S; Rice K G; Linhardt R J
Structure of heparin-derived tetrasaccharides.
The Biochemical journal 1985;229(2):369-77.
1985: Sharath M D; Merchant Z M; Kim Y S; Rice K G; Linhardt R J; Weiler J M
Small heparin fragments regulate the amplification pathway of complement.
Immunopharmacology 1985;9(2):73-80.
1984: Grant A C; Linhardt R J; Fitzgerald G L; Park J J; Langer R
Metachromatic activity of heparin and heparin fragments.
Analytical biochemistry 1984;137(1):25-32.

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