FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Robert Linhardt

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Concepts & Ideas

Phenomena

Magnetic Resonance Spectroscopy

Procedures

Living Beings

Swine

Co-author Network

Publications

TOP 3
Anne Marie Hickey; Robert J Linhardt; Ujjwal Bhaskar; Jonathan S Dordick
Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5.
Chao Cai; Kristi Edgar; Jian Liu; Robert J Linhardt
Preparation and application of a 'clickable' acceptor for enzymatic synthesis of heparin oligosaccharides.
Nikos Karamanos; Robert J Linhardt
Special Issue: Proteoglycans: signaling, targeting and therapeutics: Introduction.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Robert Linhardt (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Anne Marie Hickey; Robert J Linhardt; Ujjwal Bhaskar; Jonathan S Dordick
Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5.
Journal of biotechnology 2013;165(3-4):175-7.
2013: Chao Cai; Kristi Edgar; Jian Liu; Robert J Linhardt
Preparation and application of a 'clickable' acceptor for enzymatic synthesis of heparin oligosaccharides.
Carbohydrate research 2013;372():30-4.
2013: Nikos Karamanos; Robert J Linhardt
Special Issue: Proteoglycans: signaling, targeting and therapeutics: Introduction.
The FEBS journal 2013;280(10):2119.
2013: Li Fu; Guoyun Li; Lingyun Li; Akihiro Onishi; Peilong Sun; Bo Yang; Fuming Zhang; Robert J Linhardt
Structural characterization of pharmaceutical heparins prepared from different animal tissues.
Journal of pharmaceutical sciences 2013;102(5):1447-57.
2013: Amanda Weyers; Bo Yang; Vienna Yee; Fuming Zhang; Lingyun Li; Kemal Solakyildirim; Robert J Linhardt
Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding.
The FEBS journal 2013;280(10):2285-93.
2013: Amanda Weyers; Robert J Linhardt
Neoproteoglycans in tissue engineering.
The FEBS journal 2013;280(10):2511-22.
2013: Xianxuan Zhou; Lingyun Li; Robert J Linhardt; Jian Liu
Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase.
The FEBS journal 2013;280(10):2523-32.
2013: Payel Datta; Robert J Linhardt; Susan T Sharfstein
An 'omics approach towards CHO cell engineering.
Biotechnology and bioengineering 2013;110(5):1255-71.
2013: Odile Francesca Restaino; Priscilla Paul; Ujjwal Bhaskar; Mario De Rosa; Jonathan S Dordick; Lingyun Li; Robert J Linhardt
High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production.
Applied microbiology and biotechnology 2013;97(9):3893-900.
2013: Muchena J Kailemia; Lingyun Li; Robert J Linhardt; Jian Liu; Yongmei Xu; I Jonathan Amster
Structurally informative tandem mass spectrometry of highly sulfated natural and chemoenzymatically synthesized heparin and heparan sulfate glycosaminoglycans.
Molecular & cellular proteomics : MCP 2013;12(4):979-90.
2013: Xue Zhao; Kyohei Higashi; Eun Ji Joo; Robert J Linhardt; Kemal Solakylidirim; Toshihiko Toida; Bo Yang; Lingyun Li
Sequence analysis and domain motifs in the porcine skin decorin glycosaminoglycan chain.
The Journal of biological chemistry 2013;288(13):9226-37.
2013: Xue Zhao; Payel Datta; Kathryn Linkens; Akihiro Onishi; Bo Yang; Fuming Zhang; Robert J Linhardt
Microscale separation of heparosan, heparan sulfate, and heparin.
Analytical biochemistry 2013;434(2):215-7.
2013: Brady F Cress; Zachary R Greene; Robert J Linhardt; Mattheos A G Koffas
Draft Genome Sequence of Escherichia coli Strain ATCC 23506 (Serovar O10:K5:H4).
Genome announcements 2013;1(2):e0004913.
2013: Brady F Cress; Robert J Linhardt; Mattheos A G Koffas
Draft Genome Sequence of Escherichia coli Strain Nissle 1917 (Serovar O6:K5:H1).
Genome announcements 2013;1(2):e0004713.
2013: Brady F Cress; Zachary R Greene; Robert J Linhardt; Mattheos A G Koffas
Draft Genome Sequence of Escherichia coli Strain ATCC 23502 (Serovar O5:K4:H4).
Genome announcements 2013;1(2):e0004613.
2013: Joshua J Ziarek; Fuming Zhang; John E Baker; Gabriella A Kartz; Xinle Liang; Robert J Linhardt; Nathan J Murray; Jidong Su; Christopher T Veldkamp; Brian F Volkman
Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus.
The Journal of biological chemistry 2013;288(1):737-46.
2013: Yuqing Chang; Amanda Weyers; Bo Yang; Robert J Linhardt
Capillary electrophoresis for the analysis of glycosaminoglycan-derived disaccharides.
Methods in molecular biology (Clifton, N.J.) 2013;984():67-77.
2012: Luciana Meli; Douglas S Clark; Eric T Jordan; Robert J Linhardt; Jonathan S Dordick
Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems.
Biomaterials 2012;33(35):9087-96.
2012: Seok Joon Kwon; Kyung-Bok Lee; Lingyun Li; Mellisa Ly; Sayaka Masuko; Kemal Solakyildirim; Fuming Zhang; Jonathan S Dordick; Robert J Linhardt
Signal amplification by glyco-qPCR for ultrasensitive detection of carbohydrates: applications in glycobiology.
Angewandte Chemie (International ed. in English) 2012;51(47):11800-4.
2012: Jiraporn Suwan; Amanda Torelli; Jonathan S Dordick; Akihiro Onishi; Robert J Linhardt
Addressing endotoxin issues in bioengineered heparin.
Biotechnology and applied biochemistry 2012;59(6):420-8.
2012: Lingyun Li; Joseph Zaia; Fuming Zhang; Robert J Linhardt
Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS.
Analytical chemistry 2012;84(20):8822-9.
2012: Franklin E Leach; Robert J Linhardt; Mellisa Ly; Jacob Perlow; Jeremy J Wolff; Tatiana N Laremore; I Jonathan Amster
Hexuronic acid stereochemistry determination in chondroitin sulfate glycosaminoglycan oligosaccharides by electron detachment dissociation.
Journal of the American Society for Mass Spectrometry 2012;23(9):1488-97.
2012: Fuming Zhang; Julie M Beaudet; David M Luedeke; Thomas B Thompson; Ryan G Walker; Robert J Linhardt
Analysis of the interaction between heparin and follistatin and heparin and follistatin-ligand complexes using surface plasmon resonance.
Biochemistry 2012;51(34):6797-803.
2012: Trevor J Simmons; Xiaobo Zhan; Pulickel M Ajayan; Mariela Bravo-Sanchez; Myung Gwan Hahm; Daniel P Hashim; Robert J Linhardt; Edgar López-Luna; Hugo Navarro-Contreras; Miguel A Vidal
Functionalization of nitrogen-doped carbon nanotubes with gallium to form Ga-CN(x)-multi-wall carbon nanotube hybrid materials.
Nanotechnology 2012;23(32):325601.
2012: Yuqing Chang; Bo Yang; Xue Zhao; Robert J Linhardt
Analysis of glycosaminoglycan-derived disaccharides by capillary electrophoresis using laser-induced fluorescence detection.
Analytical biochemistry 2012;427(1):91-8.
2012: Muchena J Kailemia; Lingyun Li; Robert J Linhardt; Mellisa Ly; I Jonathan Amster
Complete mass spectral characterization of a synthetic ultralow-molecular-weight heparin using collision-induced dissociation.
Analytical chemistry 2012;84(13):5475-8.
2012: Jong Youn Baik; Robert J Linhardt; Clifford L Wang; Bo Yang; Susan Sharfstein
Toward a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells.
Bioengineered 2012;3(4):227-31.
2012: Nicola Volpi; Francesca Maccari; Jiraporn Suwan; Robert J Linhardt
Electrophoresis for the analysis of heparin purity and quality.
Electrophoresis 2012;33(11):1531-7.
2012: Priscilla Paul; Jiraporn Suwan; Jonathan S Dordick; Jian Liu; Robert J Linhardt
Recent advances in sulfotransferase enzyme activity assays.
Analytical and bioanalytical chemistry 2012;403(6):1491-500.
2012: Lingyun Li; Mellisa Ly; Robert J Linhardt
Proteoglycan sequence.
Molecular bioSystems 2012;8(6):1613-25.
2012: Thangirala Sudha; Patricia Phillips; Lubor Borsig; Camille Kanaan; Robert J Linhardt; Shaker A Mousa
Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model.
Clinical & experimental metastasis 2012;29(5):431-9.
2012: Andrea F Moon; Joseph M Krahn; Robert J Linhardt; Jian Liu; Susan M Woody; Yongmei Xu; Lars C Pedersen
Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5265-70.
2012: Robert J Linhardt; Jian Liu
Synthetic heparin.
Current opinion in pharmacology 2012;12(2):217-9.
2012: Jianjun Miao; Shaker Mousa; Majde Takieddin; Fuming Zhang; Robert J Linhardt
Adsorption of doxorubicin on poly(methyl methacrylate)-chitosan-heparin-coated activated carbon beads.
Langmuir : the ACS journal of surfaces and colloids 2012;28(9):4396-403.
2012: Nigel J Otto; Martin E Tanner; Dixy E Green; Robert J Linhardt; Sayaka Masuko; Alain Mayer; Paul L DeAngelis
Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts.
The Journal of biological chemistry 2012;287(10):7203-12.
2012: Leyla Gasimli; Robert J Linhardt; Jonathan S Dordick
Proteoglycans in stem cells.
Biotechnology and applied biochemistry 2012;59(2):65-76.
2012: Jianjun Miao; Minoru Miyauchi; Jonathan S Dordick; Robert J Linhardt
Preparation and characterization of electrospun core sheath nanofibers from multi-walled carbon nanotubes and poly(vinyl pyrrolidone).
Journal of nanoscience and nanotechnology 2012;12(3):2387-93.
2012: Amanda Weyers; Bo Yang; Dae Sung Yoon; Fuming Zhang; Kyung-Bok Lee; Jong-Hwan Park; Robert J Linhardt
A structural analysis of glycosaminoglycans from lethal and nonlethal breast cancer tissues: toward a novel class of theragnostics for personalized medicine in oncology?
Omics : a journal of integrative biology 2012;16(3):79-89.
2012: Sayaka Masuko; Robert J Linhardt
Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics.
Future medicinal chemistry 2012;4(3):289-96.
2012: Jong Youn Baik; Payel Datta; Jeffrey D Esko; Leyla Gasimli; Charles A Glass; Robert J Linhardt; Bo Yang; Fuming Zhang; Susan T Sharfstein
Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin.
Metabolic engineering 2012;14(2):81-90.
2012: Mauricio Mora-Pale; Seok Joon Kwon; Robert J Linhardt; Jonathan S Dordick
Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase.
Free radical biology & medicine 2012;52(5):962-9.
2012: Bo Yang; Yuqing Chang; Eric Sterner; Amanda M Weyers; Robert J Linhardt
Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography-mass spectrometry.
Journal of chromatography. A 2012;1225():91-8.
2012: Wen Chen; Zhenming Du; Lingyun Li; Robert J Linhardt; Jiajing Liu; Kenneth V Mills; Julie N Reitter; Chunyu Wang
Intramolecular disulfide bond between catalytic cysteines in an intein precursor.
Journal of the American Chemical Society 2012;134(5):2500-3.
2012: Sayaka Masuko; Michel Weïwer; Jian Liu; Smritilekha Bera; Paul L DeAngelis; Dixy E Green; Robert J Linhardt
Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans.
The Journal of organic chemistry 2012;77(3):1449-56.
2012: Wenjing Zhao; Scott A McCallum; Zhongping Xiao; Fuming Zhang; Robert J Linhardt
Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides.
Bioscience reports 2012;32(1):71-81.
2011: Zhenyu Wang; Fuming Zhang; Onishi Akihiro; Ujjwal Bhaskar; Samantha Cheong; Jonathan S Dordick; Jennifer Li; Robert J Linhardt
Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin.
Journal of biotechnology 2011;156(3):188-96.
2011: Jianjun Miao; Ravindra C Pangule; Elena E Paskaleva; Elizabeth E Hwang; Ravi S Kane; Robert J Linhardt; Jonathan S Dordick
Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications.
Biomaterials 2011;32(36):9557-67.
2011: Hong Wu; Thomas V Doherty; Robert J Linhardt; Jianjun Miao; Mauricio Mora-Pale; Jonathan S Dordick
Facile pretreatment of lignocellulosic biomass at high loadings in room temperature ionic liquids.
Biotechnology and bioengineering 2011;108(12):2865-75.
2011: Mellisa Ly; Toshihiko Toida; I Jonathan Amster; Tatiana N Laremore; Franklin E Leach; Robert J Linhardt
The proteoglycan bikunin has a defined sequence.
Nature chemical biology 2011;7(11):827-33.
2011: Fuming Zhang; Julie M Beaudet; Jonathan S Dordick; Mellisa Ly; Kemal Solakyildirim; Amanda Y Torelli; Zhenyu Wang; Zhongping Xiao; Bo Yang; Robert J Linhardt
Structural characterization of heparins from different commercial sources.
Analytical and bioanalytical chemistry 2011;401(9):2793-803.
2011: Yongmei Xu; Juliana Jing; Robert J Linhardt; Renpeng Liu; Sayaka Masuko; Shaker A Mousa; Majde Takieddin; Haoming Xu; Jian Liu
Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins.
Science (New York, N.Y.) 2011;334(6055):498-501.
2011: Nigel J Otto; Kemal Solakyildirim; Robert J Linhardt; Paul L DeAngelis
Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog.
Glycobiology 2011;21(10):1331-40.
2011: Sayaka Masuko; Toshihiko Toida; Zhenyu Wang; Fuming Zhang; Ujjwal Bhaskar; Jonathan S Dordick; Anne Marie Hickey; Kyohei Higashi; Robert J Linhardt
Ozonolysis of the double bond of the unsaturated uronate residue in low-molecular-weight heparin and K5 heparosan.
Carbohydrate research 2011;346(13):1962-6.
2011: Hari G Garg; Charles A Hales; Boyangzi Li; Casey N Moore; Hicham Mrabat; Lunyin Yu; Fuming Zhang; Robert J Linhardt
Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells.
Glycoconjugate journal 2011;28(6):419-26.
2011: Bo Yang; Amanda Weyers; Jong Youn Baik; Eric Sterner; Susan Sharfstein; Shaker A Mousa; Fuming Zhang; Jonathan S Dordick; Robert J Linhardt
Ultra-performance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis.
Analytical biochemistry 2011;415(1):59-66.
2011: Julie M Beaudet; Shaker Mousa; Kemal Solakyildirim; Majde Takieddin; Amanda Weyers; Bo Yang; Fuming Zhang; Robert J Linhardt
Impact of autoclave sterilization on the activity and structure of formulated heparin.
Journal of pharmaceutical sciences 2011;100(8):3396-404.
2011: Zhenyu Wang; Bo Yang; Zhenqing Zhang; Jonathan S Dordick; Jian Liu; Mellisa Ly; Shaker Mousa; Majde Takieddin; Robert J Linhardt
Control of the heparosan N-deacetylation leads to an improved bioengineered heparin.
Applied microbiology and biotechnology 2011;91(1):91-9.
2011: Minoru Miyauchi; Zachary H Shriver; Trevor J Simmons; Jianjun Miao; Udayanath Aich; Jonathan S Dordick; Jennifer E Gagner; Robert J Linhardt
Electrospun polyvinylpyrrolidone fibers with high concentrations of ferromagnetic and superparamagnetic nanoparticles.
ACS applied materials & interfaces 2011;3(6):1958-64.
2011: Mauricio Mora-Pale; Luciana Meli; Thomas V Doherty; Robert J Linhardt; Jonathan S Dordick
Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass.
Biotechnology and bioengineering 2011;108(6):1229-45.
2011: Smritilekha Bera; Robert J Linhardt
Design and synthesis of unnatural heparosan and chondroitin building blocks.
The Journal of organic chemistry 2011;76(9):3181-93.
2011: Ashwani Khurana; Peng Liu; Pasquale Mellone; Laura Lorenzon; Bruno Vincenzi; Kaustubh Datta; Bo Yang; Robert J Linhardt; Wilma L Lingle; Jeremy Chien; Alfonso Baldi; Viji Shridhar
HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells.
Cancer research 2011;71(6):2152-61.
2011: Gaurav Anand; Fuming Zhang; Robert J Linhardt; Georges Belfort
Protein-associated water and secondary structure effect removal of blood proteins from metallic substrates.
Langmuir : the ACS journal of surfaces and colloids 2011;27(5):1830-6.
2011: Zhipeng Wang; Lindsay A Flax; Melissa M Kemp; Robert J Linhardt; Miriam J Baron
Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster.
Infection and immunity 2011;79(2):606-16.
2011: Zhongping Xiao; Britney R Tappen; Mellisa Ly; Wenjing Zhao; Lauren P Canova; Huashi Guan; Robert J Linhardt
Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin.
Journal of medicinal chemistry 2011;54(2):603-10.
2011: Franklin E Leach; Robert J Linhardt; Mellisa Ly; Andre Venot; Jeremy J Wolff; Zhongping Xiao; Kanar Al-Mafraji; Sailaja Arungundram; Gerardus Josephus Boons; Tatiana N Laremore; I Jonathan Amster
Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates.
European journal of mass spectrometry (Chichester, England) 2011;17(2):167-76.
2011: Zhenyu Wang; Jonathan S Dordick; Robert J Linhardt
Escherichia coli K5 heparosan fermentation and improvement by genetic engineering.
Bioengineered bugs 2011;2(1):63-7.
2011: Boyangzi Li; Haiying Liu; Zhenqing Zhang; Hope E Stansfield; Jonathan S Dordick; Robert J Linhardt
Analysis of glycosaminoglycans in stem cell glycomics.
Methods in molecular biology (Clifton, N.J.) 2011;690():285-300.
2011: Bo Yang; Kemal Solakyildirim; Yuqing Chang; Robert J Linhardt
Hyphenated techniques for the analysis of heparin and heparan sulfate.
Analytical and bioanalytical chemistry 2011;399(2):541-57.
2011: Zhenling Liu; Zhongping Xiao; Sayaka Masuko; Wenjing Zhao; Eric Sterner; Vinod Bansal; Jawed Fareed; Jonathan S Dordick; Fuming Zhang; Robert J Linhardt
Mass balance analysis of contaminated heparin product.
Analytical biochemistry 2011;408(1):147-56.
2011: Zhongping Xiao; Wenjing Zhao; Bo Yang; Zhenqing Zhang; Huashi Guan; Robert J Linhardt
Heparinase 1 selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-alpha-D-glucopyranose (1,4) 2-O-sulfo-alpha-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages.
Glycobiology 2011;21(1):13-22.
2011: Mellisa Ly; Zhenyu Wang; Tatiana N Laremore; Fuming Zhang; Weihong Zhong; Dennis Pu; Dmitri V Zagorevski; Jonathan S Dordick; Robert J Linhardt
Analysis of E. coli K5 capsular polysaccharide heparosan.
Analytical and bioanalytical chemistry 2011;399(2):737-45.
2010: Zhenyu Wang; Mellisa Ly; Fuming Zhang; Weihong Zhong; Amy Suen; Anne Marie Hickey; Jonathan S Dordick; Robert J Linhardt
E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor.
Biotechnology and bioengineering 2010;107(6):964-73.
2010: Zhenling Liu; Sayaka Masuko; Kemal Solakyildirim; Dennis Pu; Robert J Linhardt; Fuming Zhang
Glycosaminoglycans of the porcine central nervous system.
Biochemistry 2010;49(45):9839-47.
2010: Renpeng Liu; Yongmei Xu; Miao Chen; Michel Weïwer; Xianxuan Zhou; Arlene S Bridges; Paul L DeAngelis; Qisheng Zhang; Robert J Linhardt; Jian Liu
Chemoenzymatic design of heparan sulfate oligosaccharides.
The Journal of biological chemistry 2010;285(44):34240-9.
2010: Tatiana N Laremore; Mellisa Ly; Zhenqing Zhang; Kemal Solakyildirim; Scott McCallum; Richard T Owens; Robert J Linhardt
Domain structure elucidation of human decorin glycosaminoglycans.
The Biochemical journal 2010;431(2):199-205.
2010: Sumit Bhattacharyya; Haiying Liu; Zhenqing Zhang; Murielle Jam; Pradeep K Dudeja; Gurvan MICHEL; Robert J Linhardt; Joanne K Tobacman
Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds.
The Journal of nutritional biochemistry 2010;21(10):906-13.
2010: Minoru Miyauchi; Jianjun Miao; Trevor J Simmons; Jong-Won Lee; Thomas V Doherty; Jonathan S Dordick; Robert J Linhardt
Conductive cable fibers with insulating surface prepared by coaxial electrospinning of multiwalled nanotubes and cellulose.
Biomacromolecules 2010;11(9):2440-5.
2010: Jianjun Miao; Minoru Miyauchi; Trevor J Simmons; Jonathan S Dordick; Robert J Linhardt
Electrospinning of nanomaterials and applications in electronic components and devices.
Journal of nanoscience and nanotechnology 2010;10(9):5507-19.
2010: Chao Cai; Jun Liu; Yuguo Du; Robert J Linhardt
Stereoselective total synthesis of (-)-cleistenolide.
The Journal of organic chemistry 2010;75(16):5754-6.
2010: Eun Ji Joo; Hui Yang; Youmie Park; Nam Young Park; Toshihiko Toida; Robert J Linhardt; Yeong Shik Kim
Induction of nucleolin translocation by acharan sulfate in A549 human lung adenocarcinoma.
Journal of cellular biochemistry 2010;110(5):1272-8.
2010: Mellisa Ly; Tatiana N Laremore; Robert J Linhardt
Proteoglycomics: recent progress and future challenges.
Omics : a journal of integrative biology 2010;14(4):389-99.
2010: David Shaya; Wenjing Zhao; Marie-Line Garron; Zhongping Xiao; Qizhi Cui; Zhenqing Zhang; Traian Sulea; Robert J Linhardt; Miroslaw Cygler
Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate.
The Journal of biological chemistry 2010;285(26):20051-61.
2010: Jankana Burana-osot; Noppamas Soonthornchareonnon; Saori Hosoyama; Robert J Linhardt; Toshihiko Toida
Partial depolymerization of pectin by a photochemical reaction.
Carbohydrate research 2010;345(9):1205-10.
2010: Hari G Garg; Hicham Mrabat; Lunyin Yu; Craig Freeman; Boyangzi Li; Fuming Zhang; Robert J Linhardt; Charles A Hales
Effect of carboxyl-reduced heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells.
Carbohydrate research 2010;345(9):1084-7.
2010: Tatiana N Laremore; Mellisa Ly; Kemal Solakyildirim; Dmitri V Zagorevski; Robert J Linhardt
High-resolution preparative separation of glycosaminoglycan oligosaccharides by polyacrylamide gel electrophoresis.
Analytical biochemistry 2010;401(2):236-41.
2010: Nicola Volpi; Robert J Linhardt
High-performance liquid chromatography-mass spectrometry for mapping and sequencing glycosaminoglycan-derived oligosaccharides.
Nature protocols 2010;5(6):993-1004.
2010: Jeremy J Wolff; Franklin E Leach; Tatiana N Laremore; Desmond A Kaplan; Michael L Easterling; Robert J Linhardt; I Jonathan Amster
Negative electron transfer dissociation of glycosaminoglycans.
Analytical chemistry 2010;82(9):3460-6.
2010: Zhenyu Wang; Zhenqing Zhang; Scott McCallum; Robert J Linhardt
Nuclear magnetic resonance quantification for monitoring heparosan K5 capsular polysaccharide production.
Analytical biochemistry 2010;398(2):275-7.
2010: Lunyin Yu; Hari G Garg; Boyangzi Li; Robert J Linhardt; Charles A Hales
Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats.
Current cancer drug targets 2010;10(2):229-41.
2010: Seok Joon Kwon; Moon Il Kim; Bosung Ku; Lydie Coulombel; Jin-Hwan Kim; Joseph H Shawky; Robert J Linhardt; Jonathan S Dordick
Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells.
Chembiochem : a European journal of chemical biology 2010;11(4):573-80.
2010: A-Rang Im; Youmie Park; Joon-Soo Sim; Zhenqing Zhang; Zhenling Liu; Robert J Linhardt; Yeong Shik Kim
Glycosaminoglycans from earthworms (Eisenia andrei).
Glycoconjugate journal 2010;27(2):249-57.
2010: Kemal Solakyildirim; Zhenqing Zhang; Robert J Linhardt
Ultraperformance liquid chromatography with electrospray ionization ion trap mass spectrometry for chondroitin disaccharide analysis.
Analytical biochemistry 2010;397(1):24-8.
2010: Tatiana N Laremore; Franklin E Leach; Kemal Solakyildirim; I Jonathan Amster; Robert J Linhardt
Glycosaminoglycan characterization by electrospray ionization mass spectrometry including fourier transform mass spectrometry.
Methods in enzymology 2010;478():79-108.
2010: Jeffrey G Martin; Julie M Beaudet; Jonathan S Dordick; Robert J Linhardt
Artificial organelles: digital microfluidic platform for proteoglycan and glycoprotein biosynthesis.
TheScientificWorldJournal 2010;10():997-1000.
2010: Melissa M Kemp; Robert J Linhardt
Heparin-based nanoparticles.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2010;2(1):77-87.
2010: Sumit Bhattacharyya; Kemal Solakyildirim; Zhenqing Zhang; Mei-Ling Chen; Robert J Linhardt; Joanne K Tobacman
Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate.
American journal of respiratory cell and molecular biology 2010;42(1):51-61.
2009: Young-Hyun Han; Marie-Line Garron; Hye-Yeon Kim; Wan-Seok Kim; Zhenqing Zhang; Kyeong-Seok Ryu; David Shaya; Zhongping Xiao; Chaejoon Cheong; Yeong Shik Kim; Robert J Linhardt; Young Ho Jeon; Miroslaw Cygler
Structural snapshots of heparin depolymerization by heparin lyase I.
The Journal of biological chemistry 2009;284(49):34019-27.
2009: Tatiana N Laremore; Fuming Zhang; Jonathan S Dordick; Jian Liu; Robert J Linhardt
Recent progress and applications in glycosaminoglycan and heparin research.
Current opinion in chemical biology 2009;13(5-6):633-40.
2009: Melissa M Kemp; Ashavani Kumar; Shaymaa Mousa; Evgeny Dyskin; Murat Yalcin; Pulickel M Ajayan; Robert J Linhardt; Shaker A Mousa
Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties.
Nanotechnology 2009;20(45):455104.
2009: Zhenqing Zhang; Boyangzi Li; Jiraporn Suwan; Fuming Zhang; Zhenyu Wang; Haiying Liu; Barbara Mulloy; Robert J Linhardt
Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE.
Journal of pharmaceutical sciences 2009;98(11):4017-26.
2009: Jankana Burana-osot; Saori Hosoyama; Yuzu Nagamoto; Sho Suzuki; Robert J Linhardt; Toshihiko Toida
Photolytic depolymerization of alginate.
Carbohydrate research 2009;344(15):2023-7.
2009: Hyun-Jeong Ra; Susanna Harju-Baker; Fuming Zhang; Robert J Linhardt; Carole L Wilson; William C Parks
Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans.
The Journal of biological chemistry 2009;284(41):27924-32.
2009: marco Guerrini; Zhenqing Zhang; Zachary Shriver; Annamaria Naggi; Sayaka Masuko; Robert Langer; Benito Casu; Robert J Linhardt; Giangiacomo Torri; Ram Sasisekharan
Orthogonal analytical approaches to detect potential contaminants in heparin.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):16956-61.
2009: Fuming Zhang; Zhenqing Zhang; Xinfu Lin; Andrew Beenken; Anna V Eliseenkova; Moosa Mohammadi; Robert J Linhardt
Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexes.
Biochemistry 2009;48(35):8379-86.
2009: Jeffrey Martin; Megha Gupta; Yongmei Xu; Srinivas Akella; Jian Liu; Jonathan S Dordick; Robert J Linhardt
Toward an artificial Golgi: redesigning the biological activities of heparan sulfate on a digital microfluidic chip.
Journal of the American Chemical Society 2009;131(31):11041-8.
2009: Boyangzi Li; Jiraporn Suwan; Jeffrey Martin; Fuming Zhang; Zhenqing Zhang; Debra Hoppensteadt; Melanie Clark; Jawed Fareed; Robert J Linhardt
Oversulfated chondroitin sulfate interaction with heparin-binding proteins: new insights into adverse reactions from contaminated heparins.
Biochemical pharmacology 2009;78(3):292-300.
2009: Mauricio Mora-Pale; Michel Weïwer; Jingjing Yu; Robert J Linhardt; Jonathan S Dordick
Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols.
Bioorganic & medicinal chemistry 2009;17(14):5146-52.
2009: Jiraporn Suwan; Zhenqing Zhang; Boyangzi Li; Preeyanat Vongchan; Puttinan Meepowpan; Fuming Zhang; Shaker A Mousa; Shaymaa Mousa; Bhusana Premanode; Prachya Kongtawelert; Robert J Linhardt
Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity.
Carbohydrate research 2009;344(10):1190-6.
2009: Irina G Sava; Fuming Zhang; Ioana Toma; Christian Theilacker; Boyangzhi Li; Thomas F Baumert; Otto Holst; Robert J Linhardt; johannes huebner
Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells.
The Journal of biological chemistry 2009;284(27):18194-201.
2009: Melissa M Kemp; Ashavani Kumar; Dylan Clement; Pulickel Ajayan; Shaker Mousa; Robert J Linhardt
Hyaluronan- and heparin-reduced silver nanoparticles with antimicrobial properties.
Nanomedicine (London, England) 2009;4(4):421-9.
2009: Zhenqing Zhang; Jin Xie; Haiying Liu; Jian Liu; Robert J Linhardt
Quantification of heparan sulfate disaccharides using ion-pairing reversed-phase microflow high-performance liquid chromatography with electrospray ionization trap mass spectrometry.
Analytical chemistry 2009;81(11):4349-55.
2009: Toshihiko Toida; Kenji Sato; Noriko Sakamoto; Shinobu Sakai; Saori Hosoyama; Robert J Linhardt
Solvolytic depolymerization of chondroitin and dermatan sulfates.
Carbohydrate research 2009;344(7):888-93.
2009: Nicola Volpi; Francesca Maccari; Robert J Linhardt
Quantitative capillary electrophoresis determination of oversulfated chondroitin sulfate as a contaminant in heparin preparations.
Analytical biochemistry 2009;388(1):140-5.
2009: Trevor J Simmons; Justin Bult; Daniel P Hashim; Robert J Linhardt; Pulickel M Ajayan
Noncovalent functionalization as an alternative to oxidative acid treatment of single wall carbon nanotubes with applications for polymer composites.
ACS nano 2009;3(4):865-70.
2009: Sang Hyun Lee; Thomas V Doherty; Robert J Linhardt; Jonathan S Dordick
Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis.
Biotechnology and bioengineering 2009;102(5):1368-76.
2009: Melissa M Kemp; Ashavani Kumar; Shaymaa Mousa; Tae-Joon Park; Pulickel Ajayan; Natsuki Kubotera; Shaker A Mousa; Robert J Linhardt
Synthesis of gold and silver nanoparticles stabilized with glycosaminoglycans having distinctive biological activities.
Biomacromolecules 2009;10(3):589-95.
2009: Haiying Liu; Zhenqing Zhang; Robert J Linhardt
Lessons learned from the contamination of heparin.
Natural product reports 2009;26(3):313-21.
2009: Zhenqing Zhang; Youmie Park; Melissa M Kemp; Wenjing Zhao; A-Rang Im; David Shaya; Miroslaw Cygler; Yeong Shik Kim; Robert J Linhardt
Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern.
Analytical biochemistry 2009;385(1):57-64.
2009: Fuming Zhang; Zhenqing Zhang; Robert Thistle; Lindsey McKeen; Saori Hosoyama; Toshihiko Toida; Robert J Linhardt; Patrick Page-McCaw
Structural characterization of glycosaminoglycans from zebrafish in different ages.
Glycoconjugate journal 2009;26(2):211-8.
2009: Sumit Bhattacharyya; Kemal Solakyildirim; Zhenqing Zhang; Robert J Linhardt; Joanne K Tobacman
Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance.
Malaria journal 2009;8():303.
2009: Juying Han; Fuming Zhang; Jin Xie; Robert J Linhardt; Linda M Hiebert
Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin.
Cardiovascular diabetology 2009;8():46.
2009: Jeremy J Wolff; Tatiana N Laremore; Franklin E Leach Ii; Robert J Linhardt; I Jonathan Amster
Electron capture dissociation, electron detachment dissociation and infrared multiphoton dissociation of sucrose octasulfate.
European journal of mass spectrometry (Chichester, England) 2009;15(2):275-81.
2008: Jin-Hwan Kim; Fei Huang; Mellisa Ly; Robert J Linhardt
Stereoselective synthesis of a C-linked neuraminic acid disaccharide: potential building block for the synthesis of C-analogues of polysialic acids.
The Journal of organic chemistry 2008;73(23):9497-500.
2008: Tae-Joon Park; Moo-Yeal Lee; Jonathan S Dordick; Robert J Linhardt
Signal amplification of target protein on heparin glycan microarray.
Analytical biochemistry 2008;383(1):116-21.
2008: Youmie Park; Zhenqing Zhang; Tatiana N Laremore; Boyangzi Li; Joon-Soo Sim; A-Rang Im; Mi Young Ahn; Yeong Shik Kim; Robert J Linhardt
Variation of acharan sulfate and monosaccharide composition and analysis of neutral N-glycans in African giant snail (Achatina fulica).
Glycoconjugate journal 2008;25(9):863-77.
2008: Nicola Volpi; Zhenqing Zhang; Robert J Linhardt
Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers.
Rapid communications in mass spectrometry : RCM 2008;22(22):3526-30.
2008: Tae-Joon Park; Sang-Hyun Lee; Trevor J Simmons; Jeffrey Martin; Shaker A Mousa; Elisaveta A Snezhkova; Veronika V Sarnatskaya; Vladimir G Nikolaev; Robert J Linhardt
Heparin-cellulose-charcoal composites for drug detoxification prepared using room temperature ionic liquids.
Chemical communications (Cambridge, England) 2008;(40):5022-4.
2008: Ariane I de Agostini; Ji-Cui Dong; Corinne de Vantéry Arrighi; Marie-Andrée Ramus; Isabelle Dentand-Quadri; Sébastien Thalmann; Patricia Ventura; Victoria Ibecheole; Felicia Monge; Anne-Marie Fischer; Sassan HajMohammadi; Nicholas W Shworak; Lijuan Zhang; Zhenqing Zhang; Robert J Linhardt
Human follicular fluid heparan sulfate contains abundant 3-O-sulfated chains with anticoagulant activity.
The Journal of biological chemistry 2008;283(42):28115-24.
2008: Michel Weïwer; Trevor Sherwood; Dixy E Green; Miao Chen; Paul L DeAngelis; Jian Liu; Robert J Linhardt
Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin.
The Journal of organic chemistry 2008;73(19):7631-7.
2008: Zhenqing Zhang; Scott McCallum; Jin Xie; Lidia Nieto; Francisco Corzana; Jesús Jiménez-Barbero; Miao Chen; Jian Liu; Robert J Linhardt
Solution structures of chemoenzymatically synthesized heparin and its precursors.
Journal of the American Chemical Society 2008;130(39):12998-3007.
2008: Jeremy J Wolff; Tatiana N Laremore; Hammad Aslam; Robert J Linhardt; I Jonathan Amster
Electron-induced dissociation of glycosaminoglycan tetrasaccharides.
Journal of the American Society for Mass Spectrometry 2008;19(10):1449-58.
2008: Ajit Varki; Linda G Baum; Susan L Bellis; Richard D Cummings; Jeffrey D Esko; Gerald W Hart; Robert J Linhardt; John B Lowe; Rodger P McEver; Arun Srivastava; Rita Sarkar
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
Glycobiology 2008;18(10):747-9.
2008: Zhenqing Zhang; Michel Weïwer; Boyangzi Li; Melissa M Kemp; Tyler H Daman; Robert J Linhardt
Oversulfated chondroitin sulfate: impact of a heparin impurity, associated with adverse clinical events, on low-molecular-weight heparin preparation.
Journal of medicinal chemistry 2008;51(18):5498-501.
2008: Hari G Garg; Hicham Mrabat; Lunyin Yu; Craig Freeman; Boyangzi Li; Fuming Zhang; Robert J Linhardt; Charles A Hales
Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells.
Carbohydrate research 2008;343(14):2406-10.
2008: Preeyanat Vongchan; Weerasak Nawarawong; Robert J Linhardt
Modification of solid phase red cell adherence assay for the detection of platelet antibodies in patients with thrombocytopenia.
American journal of clinical pathology 2008;130(3):455-66.
2008: Jong Hyun Nam; Fuming Zhang; Myriam Ermonval; Robert J Linhardt; Susan T Sharfstein
The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.
Biotechnology and bioengineering 2008;100(6):1178-92.
2008: Nicola Volpi; Francesca Maccari; Robert J Linhardt
Capillary electrophoresis of complex natural polysaccharides.
Electrophoresis 2008;29(15):3095-106.
2008: Youmie Park; Zhenqing Zhang; Robert J Linhardt; Ellen LeMosy
Distinct heparan sulfate compositions in wild-type and pipe-mutant eggshell matrix.
Fly 2008;2(4):175-9.
2008: Jingjing Yu; Michel Weïwer; Robert J Linhardt; Jonathan S Dordick
The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases.
Current vascular pharmacology 2008;6(3):204-17.
2008: Mohamad Warda; Fuming Zhang; Moustafa Radwan; Zhenqing Zhang; Nari Kim; Young Nam Kim; Robert J Linhardt; Jin Han
Is human placenta proteoglycan remodeling involved in pre-eclampsia?
Glycoconjugate journal 2008;25(5):441-50.
2008: Jeremy J Wolff; Tatiana N Laremore; Alexander M Busch; Robert J Linhardt; I Jonathan Amster
Influence of charge state and sodium cationization on the electron detachment dissociation and infrared multiphoton dissociation of glycosaminoglycan oligosaccharides.
Journal of the American Society for Mass Spectrometry 2008;19(6):790-8.
2008: marco Guerrini; Daniela Beccati; Zachary Shriver; Annamaria Naggi; Karthik Viswanathan; Antonella Bisio; Ishan Capila; Jonathan C. Lansing; Sara Guglieri; Blair Fraser; Ali Al-Hakim; Nur Sibel Gunay; Zhenqing Zhang; Luke Robinson; Lucinda Buhse; Moheb Nasr; Janet Woodcock; Robert Langer; Ganesh Venkataraman; Robert J Linhardt; Benito Casu; Giangiacomo Torri; Ram Sasisekharan
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Nature biotechnology 2008;26(6):669-75.
2008: Ronald Copeland; Arun Balasubramaniam; Vaibhav Tiwari; Fuming Zhang; Arlene Bridges; Robert J Linhardt; Deepak Shukla; Jian Liu
Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1.
Biochemistry 2008;47(21):5774-83.
2008: Sumit Bhattacharyya; Ravinder K Gill; Mei-Ling Chen; Fuming Zhang; Robert J Linhardt; Pradeep K Dudeja; Joanne K Tobacman
Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells.
The Journal of biological chemistry 2008;283(16):10550-8.
2008: Lianli Chi; Jeremy J Wolff; Tatiana N Laremore; Odile F Restaino; Jin Xie; Chiara Schiraldi; Toshihiko Toida; I Jonathan Amster; Robert J Linhardt
Structural analysis of bikunin glycosaminoglycan.
Journal of the American Chemical Society 2008;130(8):2617-25.
2008: Jeremy J Wolff; Tatiana N Laremore; Alexander M Busch; Robert J Linhardt; I Jonathan Amster
Electron detachment dissociation of dermatan sulfate oligosaccharides.
Journal of the American Society for Mass Spectrometry 2008;19(2):294-304.
2008: alba silipo; Zhenqing Zhang; F Javier Cañada; Antonio Molinaro; Robert J Linhardt; Jesús Jiménez-Barbero
Conformational analysis of a dermatan sulfate-derived tetrasaccharide by NMR, molecular modeling, and residual dipolar couplings.
Chembiochem : a European journal of chemical biology 2008;9(2):240-52.
2008: Saravanababu Murugesan; Jin Xie; Robert J Linhardt
Immobilization of heparin: approaches and applications.
Current topics in medicinal chemistry 2008;8(2):80-100.
2008: Zhenqing Zhang; Jin Xie; Jian Liu; Robert J Linhardt
Tandem MS can distinguish hyaluronic acid from N-acetylheparosan.
Journal of the American Society for Mass Spectrometry 2008;19(1):82-90.
2007: Shaker A Mousa; Fuming Zhang; Ahmad Aljada; Seema Chaturvedi; Majde Takieddin; Haifeng Zhang; Lianli Chi; M Cristina Castelli; Kristen Friedman; Michael M Goldberg; Robert J Linhardt
Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects.
Journal of clinical pharmacology 2007;47(12):1508-20.
2007: Zhenqing Zhang; Jin Xie; Fuming Zhang; Robert J Linhardt
Thin-layer chromatography for the analysis of glycosaminoglycan oligosaccharides.
Analytical biochemistry 2007;371(1):118-20.
2007: Bilge Eker; Prashanth Asuri; Saravanababu Murugesan; Robert J Linhardt; Jonathan S Dordick
Enzyme-carbon nanotube conjugates in room-temperature ionic liquids.
Applied biochemistry and biotechnology 2007;143(2):153-63.
2007: Alison V Nairn; Akiko Kinoshita-Toyoda; Hidenao Toyoda; Jin Xie; Kyle Harris; Stephen Dalton; Michael Kulik; James Michael Pierce; Toshihiko Toida; Kelley W Moremen; Robert J Linhardt
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation.
Journal of proteome research 2007;6(11):4374-87.
2007: Thomas Vorup-Jensen; Lianli Chi; Louise C Gjelstrup; Uffe B Jensen; Craig A Jewett; Can Xie; Motomu Shimaoka; Robert J Linhardt; Timothy A Springer
Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin.
The Journal of biological chemistry 2007;282(42):30869-77.
2007: Robert J Linhardt; Jin-Hwan Kim
Combinatorial enzymatic synthesis of heparan sulfate.
Chemistry & biology 2007;14(9):972-3.
2007: Photini Sinnis; Alida Coppi; Toshihiko Toida; Hidenao Toyoda; Akiko Kinoshita-Toyoda; Jin Xie; Melissa M Kemp; Robert J Linhardt
Mosquito heparan sulfate and its potential role in malaria infection and transmission.
The Journal of biological chemistry 2007;282(35):25376-84.
2007: Victor L Pushparaj; Shaijumon Manikoth; Ashavani Kumar; Saravanababu Murugesan; Lijie Ci; Robert Vajtai; Robert J Linhardt; Omkaram Nalamasu; Pulickel M Ajayan
Flexible energy storage devices based on nanocomposite paper.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13574-7.
2007: Robert J Linhardt; Jonathan S Dordick; Paul L Deangelis; Jian Liu
Enzymatic synthesis of glycosaminoglycan heparin.
Seminars in thrombosis and hemostasis 2007;33(5):453-65.
2007: Shinobu Sakai; Kana Hirano; Hidenao Toyoda; Robert J Linhardt; Toshihiko Toida
Matrix assisted laser desorption ionization-time of flight mass spectrometry analysis of hyaluronan oligosaccharides.
Analytica chimica acta 2007;593(2):207-13.
2007: Yuguo Du; Jun Liu; Robert J Linhardt
Facile synthesis of (+/-)-paeonilide.
The Journal of organic chemistry 2007;72(10):3952-4.
2007: Regina Goetz; Andrew Beenken; Omar A Ibrahimi; Juliya Kalinina; Shaun K Olsen; Anna V Eliseenkova; ChongFeng Xu; Thomas A Neubert; Fuming Zhang; Robert J Linhardt; Xijie Yu; Kenneth E White; Takeshi Inagaki; Steven A Kliewer; Masaya Yamamoto; Hiroshi Kurosu; Yasushi Ogawa; Makoto Kuro-o; Beate Lanske; Mohammed S Razzaque; Moosa Mohammadi
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Molecular and cellular biology 2007;27(9):3417-28.
2007: Xuejun Yuan; Dino K Ress; Robert J Linhardt
Synthesis of nor-C-linked neuraminic acid disaccharide: a versatile precursor of C-analogs of oligosialic acids and gangliosides.
The Journal of organic chemistry 2007;72(8):3085-8.
2007: Fuming Zhang; Jason S McLellan; Alondra M Ayala; Daniel J Leahy; Robert J Linhardt
Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.
Biochemistry 2007;46(13):3933-41.
2007: Saravanababu Murugesan; Shaker A Mousa; Laura J O'connor; David W Lincoln; Robert J Linhardt
Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis.
FEBS letters 2007;581(6):1157-60.
2007: Sybil C Lang Hrtska; Melissa M Kemp; Eva M Muñoz; Omaira Azizad; Mani Banerjee; Catarina Raposo; Jyothi Kumaran; Partho Ghosh; Robert J Linhardt
Investigation of the mechanism of binding between internalin B and heparin using surface plasmon resonance.
Biochemistry 2007;46(10):2697-706.
2007: Ashavani Kumar; Saravanababu Murugesan; Victor L Pushparaj; Jin Xie; Caterina Soldano; George John; Omkaram Nalamasu; Pulickel M Ajayan; Robert J Linhardt
Conducting organic-metallic composite submicrometer rods based on ionic liquids.
Small (Weinheim an der Bergstrasse, Germany) 2007;3(3):429-33.
2007: Jeremy J Wolff; Lianli Chi; Robert J Linhardt; I Jonathan Amster
Distinguishing glucuronic from iduronic acid in glycosaminoglycan tetrasaccharides by using electron detachment dissociation.
Analytical chemistry 2007;79(5):2015-22.
2007: Tae-Joon Park; Michel Weïwer; Xuejun Yuan; Sultan N Baytas; Eva M Munoz; Saravanababu Murugesan; Robert J Linhardt
Glycosylation in room temperature ionic liquid using unprotected and unactivated donors.
Carbohydrate research 2007;342(3-4):614-20.
2007: Tatiana N Laremore; Fuming Zhang; Robert J Linhardt
Ionic liquid matrix for direct UV-MALDI-TOF-MS analysis of dermatan sulfate and chondroitin sulfate oligosaccharides.
Analytical chemistry 2007;79(4):1604-10.
2007: Joanne C Krupa; David Shaya; Lianli Chi; Robert J Linhardt; Miroslaw Cygler; Stephen G Withers; John S Mort
Quantitative continuous assay for hyaluronan synthase.
Analytical biochemistry 2007;361(2):218-25.
2007: Jeremy J Wolff; I Jonathan Amster; Lianli Chi; Robert J Linhardt
Electron detachment dissociation of glycosaminoglycan tetrasaccharides.
Journal of the American Society for Mass Spectrometry 2007;18(2):234-44.
2007: Preeyanat Vongchan; Robert J Linhardt
Expression of human liver HSPGs on acute myeloid leukemia.
Clinical immunology (Orlando, Fla.) 2007;122(2):194-206.
2007: Breca S Tracy; Fikri Y Avci; Robert J Linhardt; Paul L DeAngelis
Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans.
The Journal of biological chemistry 2007;282(1):337-44.
2007: Qing Ma; Umberto Cornelli; Israel Hanin; Walter P Jeske; Robert J Linhardt; Jeanine M Walenga; Jawed Fareed; John Lee
Heparin oligosaccharides as potential therapeutic agents in senile dementia.
Current pharmaceutical design 2007;13(15):1607-16.
2007: Tatiana N Laremore; Robert J Linhardt
Improved matrix-assisted laser desorption/ionization mass spectrometric detection of glycosaminoglycan disaccharides as cesium salts.
Rapid communications in mass spectrometry : RCM 2007;21(7):1315-20.
2007: Qing Ma; Mahmut Tobu; Christopher Schultz; Walter P Jeske; Debra Hoppensteadt; Jeanine M Walenga; Umberto Cornelli; John Lee; Robert J Linhardt; Israel Hanin; Jawed Fareed
Molecular weight dependent tissue factor pathway inhibitor release by heparin and heparin oligosaccharides.
Thrombosis research 2007;119(5):653-61.
2006: Shaker A Mousa; Robert J Linhardt; John L Francis; Ali Amirkhosravi
Anti-metastatic effect of a non-anticoagulant low-molecular-weight heparin versus the standard low-molecular-weight heparin, enoxaparin.
Thrombosis and haemostasis 2006;96(6):816-21.
2006: Young Wan Ha; Yun-Cheol Na; Jung-Ju Seo; Soo-Na Kim; Robert J Linhardt; Yeong Shik Kim
Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry.
Journal of chromatography. A 2006;1135(1):27-35.
2006: Hari G Garg; Charles A Hales; Lunyin Yu; Melissa Butler; Tasneem Islam; Jin Xie; Robert J Linhardt
Increase in the growth inhibition of bovine pulmonary artery smooth muscle cells by an O-hexanoyl low-molecular-weight heparin derivative.
Carbohydrate research 2006;341(15):2607-12.
2006: Mohamad Warda; Toshihiko Toida; Fuming Zhang; Peilong Sun; Eva M Munoz; Jin Xie; Robert J Linhardt
Isolation and characterization of heparan sulfate from various murine tissues.
Glycoconjugate journal 2006;23(7-8):555-63.
2006: Heidi Barth; Eva K Schnober; Fuming Zhang; Robert J Linhardt; Erik Depla; Bertrand Boson; François-Loïc Cosset; Arvind H Patel; Hubert E Blum; Thomas F Baumert
Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction.
Journal of virology 2006;80(21):10579-90.
2006: Saravanababu Murugesan; Shaker A Mousa; Aravind Vijayaraghavan; Pulickel M Ajayan; Robert J Linhardt
Ionic liquid-derived blood-compatible composite membranes for kidney dialysis.
Journal of biomedical materials research. Part B, Applied biomaterials 2006;79(2):298-304.
2006: Yuguo Du; Qi Chen; Robert J Linhardt
The first total synthesis of sporiolide A.
The Journal of organic chemistry 2006;71(22):8446-51.
2006: Chenghua Shao; Fuming Zhang; Melissa M Kemp; Robert J Linhardt; David M Waisman; James F Head; Barbara A Seaton
Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
The Journal of biological chemistry 2006;281(42):31689-95.
2006: Ashavani Kumar; Victor L Pushparaj; Saravanababu Murugesan; Gunaranjan Viswanathan; Rohit Nalamasu; Robert J Linhardt; Omkaram Nalamasu; Pulickel M Ajayan
Synthesis of silica-gold nanocomposites and their porous nanoparticles by an in-situ approach.
Langmuir : the ACS journal of surfaces and colloids 2006;22(21):8631-4.
2006: Jeremy E Turnbull; Robert J Linhardt
Synthetic sugars enhance the functional glycomics toolkit.
Nature chemical biology 2006;2(9):449-50.
2006: Shinobu Sakai; Hiroshi Akiyama; Yuji Sato; Yasuo Yoshioka; Robert J Linhardt; Yukihiro Goda; Tamio Maitani; Toshihiko Toida
Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice.
The Journal of biological chemistry 2006;281(29):19872-80.
2006: Fuming Zhang; Peilong Sun; Eva Muñoz; Lianli Chi; Shinobu Sakai; Toshihiko Toida; Haifeng Zhang; Shaker A Mousa; Robert J Linhardt
Microscale isolation and analysis of heparin from plasma using an anion-exchange spin column.
Analytical biochemistry 2006;353(2):284-6.
2006: Lianli Chi; Eva M Munoz; Hyung Seok Choi; Young Wan Ha; Yeong Shik Kim; Toshihiko Toida; Robert J Linhardt
Preparation and structural determination of large oligosaccharides derived from acharan sulfate.
Carbohydrate research 2006;341(7):864-9.
2006: Bruce Daniels; Robert J Linhardt; Fuming Zhang; Wenjun Mao; Sandra M Wice; Linda M Hiebert
In vivo antithrombotic synergy of oral heparin and arginine: endothelial thromboresistance without changes in coagulation parameters.
Thrombosis and haemostasis 2006;95(5):865-72.
2006: Eva Muñoz; Ding Xu; Melissa Kemp; Fuming Zhang; Jian Liu; Robert J Linhardt
Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate.
Biochemistry 2006;45(16):5122-8.
2006: Saravanababu Murugesan; Tae-Joon Park; Hoichang Yang; Shaker A Mousa; Robert J Linhardt
Blood compatible carbon nanotubes--nano-based neoproteoglycans.
Langmuir : the ACS journal of surfaces and colloids 2006;22(8):3461-3.
2006: Tatiana N Laremore; Saravanababu Murugesan; Tae-Joon Park; Fikri Y Avci; Dmitri V Zagorevski; Robert J Linhardt
Matrix-assisted laser desorption/ionization mass spectrometric analysis of uncomplexed highly sulfated oligosaccharides using ionic liquid matrices.
Analytical chemistry 2006;78(6):1774-9.
2006: Ji Young Suk; Fuming Zhang; William E Balch; Robert J Linhardt; Jeffery W Kelly
Heparin accelerates gelsolin amyloidogenesis.
Biochemistry 2006;45(7):2234-42.
2006: Yuguo Du; Jun Liu; Robert J Linhardt
Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B) from D-xylose.
The Journal of organic chemistry 2006;71(3):1251-3.
2006: Gunaranjan Viswanathan; Saravanababu Murugesan; Victor L Pushparaj; Omkaram Nalamasu; Pulickel M Ajayan; Robert J Linhardt
Preparation of biopolymer fibers by electrospinning from room temperature ionic liquids.
Biomacromolecules 2006;7(2):415-8.
2006: Shaun K Olsen; James Y H Li; Carrie Bromleigh; Anna V Eliseenkova; Omar A Ibrahimi; Zhimin Lao; Fuming Zhang; Robert J Linhardt; Alexandra L Joyner; Moosa Mohammadi
Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
Genes & development 2006;20(2):185-98.
2006: Eva Muñoz; Ding Xu; Fikri Y Avci; Melissa Kemp; Jian Liu; Robert J Linhardt
Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions.
Biochemical and biophysical research communications 2006;339(2):597-602.
2006: Toshihiko Toida; Shinobu Sakai; Hiroshi Akiyama; Robert J Linhardt
Immunological activity of chondroitin sulfate.
Advances in pharmacology (San Diego, Calif.) 2006;53():403-15.
2006: Robert J Linhardt; Fikri Y Avci; Toshihiko Toida; Yeong Shik Kim; Miroslaw Cygler
CS lyases: structure, activity, and applications in analysis and the treatment of diseases.
Advances in pharmacology (San Diego, Calif.) 2006;53():187-215.
2006: Mohamad Warda; Robert J Linhardt
Dromedary glycosaminoglycans: molecular characterization of camel lung and liver heparan sulfate.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2006;143(1):37-43.
2005: Jinghua Chen; Fikri Y Avci; Eva M Muñoz; Lynda M McDowell; Miao Chen; Lars C Pedersen; Lijuan Zhang; Robert J Linhardt; Jian Liu
Enzymatic redesigning of biologically active heparan sulfate.
The Journal of biological chemistry 2005;280(52):42817-25.
2005: Haining Yu; Eva M Muñoz; R Erik Edens; Robert J Linhardt
Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance.
Biochimica et biophysica acta 2005;1726(2):168-76.
2005: Xijie Yu; Omar A Ibrahimi; Regina Goetz; Fuming Zhang; Siobhan I Davis; Holly J Garringer; Robert J Linhardt; David M Ornitz; Moosa Mohammadi; Kenneth E White
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.
Endocrinology 2005;146(11):4647-56.
2005: Kana Hirano; Shinobu Sakai; Tsutomu Ishikawa; Fikri Y Avci; Robert J Linhardt; Toshihiko Toida
Preparation of the methyl ester of hyaluronan and its enzymatic degradation.
Carbohydrate research 2005;340(14):2297-304.
2005: Dino K Ress; Sultan N Baytas; Qun Wang; Eva M Muñoz; Kazuo Tokuzoki; Hiroshi Tomiyama; Robert J Linhardt
Synthesis of double C-glycoside analogue of sTn.
The Journal of organic chemistry 2005;70(20):8197-200.
2005: Eva M Muñoz; Haining Yu; Jeannette Hallock; R Erik Edens; Robert J Linhardt
Poly(ethylene glycol)-based biosensor chip to study heparin-protein interactions.
Analytical biochemistry 2005;343(1):176-8.
2005: Joon-Soo Sim; Gyungjin Jun; Toshihiko Toida; So Yean Cho; Don Woong Choi; Seung-Yeup Chang; Robert J Linhardt; Yeong Shik Kim
Quantitative analysis of chondroitin sulfate in raw materials, ophthalmic solutions, soft capsules and liquid preparations.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;818(2):133-9.
2005: Young Wan Ha; Byong-Tae Jeon; Sang Ho Moon; Hidenao Toyoda; Toshihiko Toida; Robert J Linhardt; Yeong Shik Kim
Characterization of heparan sulfate from the unossified antler of Cervus elaphus.
Carbohydrate research 2005;340(3):411-6.
2005: Preeyanat Vongchan; Mohamad Warda; Hidenao Toyoda; Toshihiko Toida; Rory M Marks; Robert J Linhardt
Structural characterization of human liver heparan sulfate.
Biochimica et biophysica acta 2005;1721(1-3):1-8.
2005: Xuejun Yuan; Robert J Linhardt
Recent advances in the synthesis of C-oligosaccharides.
Current topics in medicinal chemistry 2005;5(14):1393-430.
2005: Omar A Ibrahimi; Brian K Yeh; Anna V Eliseenkova; Fuming Zhang; Shaun K Olsen; Makoto Igarashi; Stuart A Aaronson; Robert J Linhardt; Moosa Mohammadi
Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization.
Molecular and cellular biology 2005;25(2):671-84.
2005: Eun Ji Joo; Gerdy B ten Dam; Toin H van Kuppevelt; Toshihiko Toida; Robert J Linhardt; Yeong Shik Kim
Nucleolin: acharan sulfate-binding protein on the surface of cancer cells.
Glycobiology 2005;15(1):1-9.
2004: Fuming Zhang; Andrew D Bries; Sybil C Lang; Qun Wang; David W Murhammer; John M Weiler; Robert J Linhardt
Metabolic alteration of the N-glycan structure of a protein from patients with a heterozygous protein deficiency.
Biochimica et biophysica acta 2004;1739(1):43-9.
2004: Andrea F Moon; Suzanne C Edavettal; Joseph M Krahn; Eva M Munoz; Masahiko Negishi; Robert J Linhardt; Jian Liu; Lars C Pedersen
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.
The Journal of biological chemistry 2004;279(43):45185-93.
2004: Sultan N Baytas; Qun Wang; Nathalie A Karst; Jonathan S Dordick; Robert J Linhardt
Solid-phase chemoenzymatic synthesis of C-sialosides.
The Journal of organic chemistry 2004;69(20):6900-3.
2004: Omar A Ibrahimi; Fuming Zhang; Anna V Eliseenkova; Nobuyuki Itoh; Robert J Linhardt; Moosa Mohammadi
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.
Human molecular genetics 2004;13(19):2313-24.
2004: Eva M Muñoz; Robert J Linhardt
Heparin-binding domains in vascular biology.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1549-57.
2004: Hiroshi Akiyama; Shinobu Sakai; Robert J Linhardt; Yukihiro Goda; Toshihiko Toida; Tamio Maitani
Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin.
The Biochemical journal 2004;382(Pt 1):269-78.
2004: GUOFENG GU; Yuguo Du; Robert J Linhardt
Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.
The Journal of organic chemistry 2004;69(16):5497-500.
2004: Gurvan MICHEL; Kevin Pojasek; Yunge Li; Traian Sulea; Robert J Linhardt; Rahul Raman; Vikas Prabhakar; Ram Sasisekharan; Miroslaw Cygler
The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery.
The Journal of biological chemistry 2004;279(31):32882-96.
2004: Robert J Linhardt; Toshihiko Toida
Role of glycosaminoglycans in cellular communication.
Accounts of chemical research 2004;37(7):431-8.
2004: Fuming Zhang; Yi Wu; Qing Ma; Debra Hoppensteadt; Jawed Fareed; Robert J Linhardt
Studies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2004;10(3):249-57.
2004: Suzanne C Edavettal; Karen A Lee; Masahiko Negishi; Robert J Linhardt; Jian Liu; Lars C Pedersen
Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1.
The Journal of biological chemistry 2004;279(24):25789-97.
2004: Fuming Zhang; Francesca Ronca; Robert J Linhardt; Richard U Margolis
Structural determinants of heparan sulfate interactions with Slit proteins.
Biochemical and biophysical research communications 2004;317(2):352-7.
2004: Omar A Ibrahimi; Fuming Zhang; Sybil C Lang Hrstka; Moosa Mohammadi; Robert J Linhardt
Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly.
Biochemistry 2004;43(16):4724-30.
2004: Robert J Linhardt
Heparin-induced cancer cell death.
Chemistry & biology 2004;11(4):420-2.
2004: Francis C Peterson; E Sonay Elgin; Timothy J Nelson; Fuming Zhang; Theresa J Hoeger; Robert J Linhardt; Brian F Volkman
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin.
The Journal of biological chemistry 2004;279(13):12598-604.
2004: Yuguo Du; Guohua Wei; Robert J Linhardt
Total synthesis of quercetin 3-sophorotrioside.
The Journal of organic chemistry 2004;69(6):2206-9.
2004: Vladimir V Lunin; Yunge Li; Robert J Linhardt; Hirofumi Miyazono; Mamoru Kyogashima; Takuji Kaneko; Alexander (Alex) Bell; Miroslaw Cygler
High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism.
Journal of molecular biology 2004;337(2):367-86.
2004: Shaun K Olsen; Omar A Ibrahimi; Angela Raucci; Fuming Zhang; Anna V Eliseenkova; Avner Yayon; Claudio Basilico; Robert J Linhardt; Joseph Schlessinger; Moosa Mohammadi
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):935-40.
2004: Charuwan Thanawiroon; Kevin G Rice; Toshihiko Toida; Robert J Linhardt
Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides.
The Journal of biological chemistry 2004;279(4):2608-15.
2004: Da Wei Li; In Sun Lee; Joon-Soo Sim; Toshihiko Toida; Robert J Linhardt; Yeong Shik Kim
Long duration of anticoagulant activity and protective effects of acharan sulfate in vivo.
Thrombosis research 2004;113(1):67-73.
2004: Omar A Ibrahimi; Fuming Zhang; Anna V Eliseenkova; Robert J Linhardt; Moosa Mohammadi
Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity.
Human molecular genetics 2004;13(1):69-78.
2003: Nathalie A Karst; Tasneem F Islam; Robert J Linhardt
Sulfo-protected hexosamine monosaccharides: potentially versatile building blocks for glycosaminoglycan synthesis.
Organic letters 2003;5(25):4839-42.
2003: Mohamad Warda; Eman M Gouda; Toshihiko Toida; Lianli Chi; Robert J Linhardt
Isolation and characterization of raw heparin from dromedary intestine: evaluation of a new source of pharmaceutical heparin.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2003;136(4):357-65.
2003: So Yean Cho; Joon-Soo Sim; Sam Sik Kang; Choon Sik Jeong; Robert J Linhardt; Yeong Shik Kim
Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins.
Archives of pharmacal research 2003;26(12):1102-8.
2003: Hari G Garg; Lunyin Yu; Charles A Hales; Toshihiko Toida; Tasneem Islam; Robert J Linhardt
Sulfation patterns in heparin and heparan sulfate: effects on the proliferation of bovine pulmonary artery smooth muscle cells.
Biochimica et biophysica acta 2003;1639(3):225-31.
2003: Dharmendar Rathore; Sybil C L Hrstka; John B Sacci; Patricia de la Vega; Robert J Linhardt; Sanjai Kumar; Thomas F McCutchan
Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein.
The Journal of biological chemistry 2003;278(42):40905-10.
2003: Heidi Barth; Christiane Schafer; Mohammed I Adah; Fuming Zhang; Robert J Linhardt; Hidenao Toyoda; Akiko Kinoshita-Toyoda; Toshihiko Toida; Toin H van Kuppevelt; Erik Depla; Fritz Von Weizsacker; Hubert E Blum; Thomas F Baumert
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate.
The Journal of biological chemistry 2003;278(42):41003-12.
2003: Nur Sibel Gunay; Robert J Linhardt
Capillary electrophoretic separation of heparin oligosaccharides under conditions amenable to mass spectrometric detection.
Journal of chromatography. A 2003;1014(1-2):225-33.
2003: Charuwan Thanawiroon; Robert J Linhardt
Separation of a complex mixture of heparin-derived oligosaccharides using reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 2003;1014(1-2):215-23.
2003: Yuguo Du; GUOFENG GU; Guohua Wei; Yuxia Hua; Robert J Linhardt
Synthesis of saponins using partially protected glycosyl donors.
Organic letters 2003;5(20):3627-30.
2003: Nathalie A Karst; Robert J Linhardt
Recent chemical and enzymatic approaches to the synthesis of glycosaminoglycan oligosaccharides.
Current medicinal chemistry 2003;10(19):1993-2031.
2003: Fikri Y Avci; Toshihiko Toida; Robert J Linhardt
Chondroitin O-methyl ester: an unusual substrate for chondroitin AC lyase.
Carbohydrate research 2003;338(20):2101-4.
2003: Nur Sibel Gunay; Keiko Tadano-Aritomi; Toshihiko Toida; Ineo Ishizuka; Robert J Linhardt
Evaluation of counterions for electrospray ionization mass spectral analysis of a highly sulfated carbohydrate, sucrose octasulfate.
Analytical chemistry 2003;75(13):3226-31.
2003: Robert J Linhardt
2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.
Journal of medicinal chemistry 2003;46(13):2551-64.
2003: Balagurunathan Kuberan; Sulthan A Sikkander; Hiroshi Tomiyama; Robert J Linhardt
Synthesis of a C-glycoside analogue of sTn: an HIV- and tumor-associated antigen.
Angewandte Chemie (International ed. in English) 2003;42(18):2073-5.
2003: Qun Wang; Jonathan S Dordick; Robert J Linhardt
Chemoenzymatic synthesis of neuraminic acid containing C-glycoside polymers.
Organic letters 2003;5(8):1187-9.
2003: Qun Wang; Robert J Linhardt
Synthesis of a serine-based neuraminic acid C-glycoside.
The Journal of organic chemistry 2003;68(7):2668-72.
2003: Yeon Sil Lee; Hyun Ok Yang; Kuk Hyun Shin; Hyung Seok Choi; Sang Hoon Jung; Yong Man Kim; Deok-Kun Oh; Robert J Linhardt; Yeong Shik Kim
Suppression of tumor growth by a new glycosaminoglycan isolated from the African giant snail Achatina fulica.
European journal of pharmacology 2003;465(1-2):191-8.
2003: Tülay Polat; Robert J Linhardt
Zinc triflate-benzoyl bromide: a versatile reagent for the conversion of ether into benzoate protecting groups and ether glycosides into glycosyl bromides.
Carbohydrate research 2003;338(5):447-9.
2003: Fikri Y Avci; Nathalie A Karst; Robert J Linhardt
Synthetic oligosaccharides as heparin-mimetics displaying anticoagulant properties.
Current pharmaceutical design 2003;9(28):2323-35.
2003: Robert J Linhardt; Toshihiko Toida
Characterization of glycosaminoglycans by capillary electrophoresis.
Methods in molecular biology (Clifton, N.J.) 2003;213():131-44.
2003: Mohamad Warda; Wenjun Mao; Toshihiko Toida; Robert J Linhardt
Turkey intestine as a commercial source of heparin? Comparative structural studies of intestinal avian and mammalian glycosaminoglycans.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;134(1):189-97.
2002: Hari G Garg; Naiyaratana Cindhuchao; Deborah A Quinn; Charles A Hales; Charuwan Thanawiroon; Ishan Capila; Robert J Linhardt
Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferation.
Carbohydrate research 2002;337(21-23):2359-64.
2002: Tasneem Islam; Melissa Butler; Sulthan A Sikkander; Toshihiko Toida; Robert J Linhardt
Further evidence that periodate cleavage of heparin occurs primarily through the antithrombin binding site.
Carbohydrate research 2002;337(21-23):2239-43.
2002: Robert J Linhardt; Toshihiko Toida
Tech.Sight. Capillary electrophoresis. Ultra-high resolution separation comes of age.
Science (New York, N.Y.) 2002;298(5597):1441-2.
2002: Guangli Yu; Nur Sibel Gunay; Robert J Linhardt; Toshihiko Toida; Jawed Fareed; Debra A Hoppensteadt; Hazar Shadid; Vito Ferro; Caiping Li; Kym Fewings; Maria C Palermo; Denis Podger
Preparation and anticoagulant activity of the phosphosulfomannan PI-88.
European journal of medicinal chemistry 2002;37(10):783-91.
2002: Brian K Yeh; Anna V Eliseenkova; Alexander N Plotnikov; David Green; Jared Pinnell; Tulay Polat; Amel Gritli-Linde; Robert J Linhardt; Moosa Mohammadi
Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfate.
Molecular and cellular biology 2002;22(20):7184-92.
2002: Paul L DeAngelis; Nur Sibel Gunay; Toshihiko Toida; Wen-jun Mao; Robert J Linhardt
Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively.
Carbohydrate research 2002;337(17):1547-52.
2002: Jutta Bürgermeister; Dietrich Paper; Horst Vogl; Robert J Linhardt; Gerhard Franz
LaPSvS1, a (1-->3)-beta-galactan sulfate and its effect on angiogenesis in vivo and in vitro.
Carbohydrate research 2002;337(16):1459-66.
2002: Jian Liu; Zach Shriver; Marshall pope; Suzanne C Thorp; Michael B Duncan; Ronald J Copeland; Christina S Raska; Keiichi Yoshida; Roselyn J Eisenberg; Gary Cohen; Robert J Linhardt; Ram Sasisekharan
Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D.
The Journal of biological chemistry 2002;277(36):33456-67.
2002: Hélène G Bazin; Marcos A Marques; Albert P Owens; Robert J Linhardt; keith crutcher
Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides.
Biochemistry 2002;41(25):8203-11.
2002: Amornrut Chaidedgumjorn; Atsushi Suzuki; Hidenao Toyoda; Toshihiko Toida; Toshio Imanari; Robert J Linhardt
Conductivity detection for molecular mass estimation of per-O-sulfonated glycosaminoglycans separated by high-performance size-exclusion chromatography.
Journal of chromatography. A 2002;959(1-2):95-102.
2002: Ishan Capila; Yi Wu; David W Rethwisch; Allan Matte; Miroslaw Cygler; Robert J Linhardt
Role of arginine 292 in the catalytic activity of chondroitin AC lyase from Flavobacterium heparinum.
Biochimica et biophysica acta 2002;1597(2):260-70.
2002: Linda M Hiebert; Sandra M Wice; Tilly Ping; Ronald E Hileman; Tfilay Polat; Robert J Linhardt
Tissue distribution of [14C]sucrose octasulfate following oral administration to rats.
Pharmaceutical research 2002;19(6):838-44.
2002: Fuming Zhang; David W Murhammer; Robert J Linhardt
Enzyme kinetics and glycan structural characterization of secreted alkaline phosphatase prepared using the baculovirus expression vector system.
Applied biochemistry and biotechnology 2002;101(3):197-210.
2002: Maria J Hernaiz; Laurie A LeBrun; Yi Wu; Jette W Sen; Robert J Linhardt; Niels H H Heegaard
Characterization of heparin binding by a peptide from amyloid P component using capillary electrophoresis, surface plasmon resonance and isothermal titration calorimetry.
European journal of biochemistry / FEBS 2002;269(12):2860-7.
2002: Fuming Zhang; Melissa A Fath; Rory M Marks; Robert J Linhardt
A highly stable covalent conjugated heparin biochip for heparin-protein interaction studies.
Analytical biochemistry 2002;304(2):271-3.
2002: Els M A van de Westerlo; Toon F C M Smetsers; Michel A B A Dennissen; Robert J Linhardt; Jacques H Veerkamp; Goos N P van Muijen; Toin H van Kuppevelt
Human single chain antibodies against heparin: selection, characterization, and effect on coagulation.
Blood 2002;99(7):2427-33.
2002: Wenjun Mao; Charuwan Thanawiroon; Robert J Linhardt
Capillary electrophoresis for the analysis of glycosaminoglycans and glycosaminoglycan-derived oligosaccharides.
Biomedical chromatography : BMC 2002;16(2):77-94.
2002: Shinobu Sakai; Jun-ichi Onose; Haruka Nakamura; Hidenao Toyoda; Toshihiko Toida; Toshio Imanari; Robert J Linhardt
Pretreatment procedure for the microdetermination of chondroitin sulfate in plasma and urine.
Analytical biochemistry 2002;302(2):169-74.
2002: Guangli Yu; Huashi Guan; Alexandra S Ioanoviciu; Sulthan A Sikkander; Charuwan Thanawiroon; Joanne K Tobacman; Toshihiko Toida; Robert J Linhardt
Structural studies on kappa-carrageenan derived oligosaccharides.
Carbohydrate research 2002;337(5):433-40.
2002: Qing Ma; Bertalan Dudas; Asif Daud; Omer Iqbal; Debra Hoppensteadt; Walter P Jeske; Umberto Cornelli; John Lee; Stanley Lorens; Ronald Mervis; Israel Hanin; Ishan Capila; Robert J Linhardt; Jawed Fareed
Molecular and biochemical profiling of a heparin-derived oligosaccharide, C3.
Thrombosis research 2002;105(4):303-9.
2002: Vito Ferro; Caiping Li; Kym Fewings; Maria C Palermo; Robert J Linhardt; Toshihiko Toida
Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.
Carbohydrate research 2002;337(2):139-46.
2002: Ishan Capila; Robert J Linhardt
Heparin-protein interactions.
Angewandte Chemie (International ed. in English) 2002;41(3):391-412.
2002: So Yean Cho; Jong Sik Kim; Hong Li; Changkoo Shim; Robert J Linhardt; Yeong Shik Kim
Enhancement of paracellular transport of heparin disaccharide across Caco-2 cell monolayers.
Archives of pharmacal research 2002;25(1):86-92.
2002: Fuming Zhang; Mark A Saarinen; Laura J Itle; Sybil C Lang; David W Murhammer; Robert J Linhardt
The effect of dissolved oxygen (DO) concentration on the glycosylation of recombinant protein produced by the insect cell-baculovirus expression system.
Biotechnology and bioengineering 2002;77(2):219-24.
2001: S Ye; Y Luo; W Lu; R B Jones; Robert J Linhardt; Ishan Capila; Toshihiko Toida; M Kan; H Pelletier; Wallace L McKeehan
Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry 2001;40(48):14429-39.
2001: J Jeong; T Toida; Y Muneta; I Kosiishi; T Imanari; Robert J Linhardt; H S Choi; SJ Wu; Yeong Shik Kim
Localization and characterization of acharan sulfate in the body of the giant African snail Achatina fulica.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;130(4):513-9.
2001: C P Libeu; Sissel Lund-Katz; Michael C Phillips; Suzanne Wehrli; MJ Hernáiz; Ishan Capila; Robert J Linhardt; Robert L Raffaï; Yvonne Newhouse; F Zhou; Karl H Weisgraber
New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.
The Journal of biological chemistry 2001;276(42):39138-44.
2001: Dharmendar Rathore; Thomas F McCutchan; D N Garboczi; T Toida; MJ Hernáiz; Laurie A LeBrun; S C Lang; Robert J Linhardt
Direct measurement of the interactions of glycosaminoglycans and a heparin decasaccharide with the malaria circumsporozoite protein.
Biochemistry 2001;40(38):11518-24.
2001: MW Wolff; Fuming Zhang; J J Roberg; EE Caldwell; P R Kaul; J N Serrahn; David W Murhammer; Robert J Linhardt; John M Weiler
Expression of C1 esterase inhibitor by the baculovirus expression vector system: preparation, purification, and characterization.
Protein expression and purification 2001;22(3):414-21.
2001: R Erik Edens; Laurie A LeBrun; Robert J Linhardt; P R Kaul; John M Weiler
Certain high molecular weight heparin chains have high affinity for vitronectin.
Archives of biochemistry and biophysics 2001;391(2):278-85.
2001: Rory M Marks; H Lu; R Sundaresan; T Toida; A Suzuki; T Imanari; MJ Hernáiz; Robert J Linhardt
Probing the interaction of dengue virus envelope protein with heparin: assessment of glycosaminoglycan-derived inhibitors.
Journal of medicinal chemistry 2001;44(13):2178-87.
2001: Robert J Linhardt
Analysis of glycosaminoglycans with polysaccharide lyases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 17():Unit17.13B.
2001: J Dong; Clare A Peters-Libeu; Karl H Weisgraber; Brent W Segelke; Bernhard Rupp; Ishan Capila; MJ Hernáiz; Laurie A LeBrun; Robert J Linhardt
Interaction of the N-terminal domain of apolipoprotein E4 with heparin.
Biochemistry 2001;40(9):2826-34.
2001: Weijun Huang; Lorena I Boju; L Tkalec; H Su; HO Yang; Nur Sibel Gunay; Robert J Linhardt; YS Kim; Allan Matte; Miroslaw Cygler
Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
Biochemistry 2001;40(8):2359-72.
2001: Fuming Zhang; MW Wolff; D Williams; K Busch; Sybil C Lang; David W Murhammer; Robert J Linhardt
Affinity purification of secreted alkaline phosphatase produced by baculovirus expression vector system.
Applied biochemistry and biotechnology 2001;90(2):125-36.
2001: M Koketsu; Robert J Linhardt
X-ray diffraction and high-resolution NMR spectroscopic analysis of 2,4,7,8-tetra-O-acetyl-3-deoxy-alpha-D-manno-2-octulopyranosono-1,5-lactone.
Carbohydrate research 2001;330(1):145-7.
2001: Ishan Capila; MJ Hernáiz; YD Mo; Tanya R Mealy; Begoña Campos; John R Dedman; Robert J Linhardt; Barbara A Seaton
Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Structure (London, England : 1993) 2001;9(1):57-64.
2001: MJ Hernáiz; Robert J Linhardt
Degradation of chondroitin sulfate and dermatan sulfate with chondroitin lyases.
Methods in molecular biology (Clifton, N.J.) 2001;171():363-71.
2001: Laurie A LeBrun; Robert J Linhardt
Degradation of heparan sulfate with heparin lyases.
Methods in molecular biology (Clifton, N.J.) 2001;171():353-61.
2000: Guangli Yu; Laurie A LeBrun; Nur Sibel Gunay; D Hoppensteadt; J M Walenga; Jawed Fareed; Robert J Linhardt
Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.
Thrombosis research 2000;100(6):549-56.
2000: J Choe; Fuming Zhang; MW Wolff; David W Murhammer; Robert J Linhardt; Jonathan S Dordick
Separation of alpha-acid glycoprotein glycoforms using affinity-based reversed micellar extraction and separation.
Biotechnology and bioengineering 2000;70(5):484-90.
2000: F Dasgupta; R I Masada; C M Starr; Balagurunathan Kuberan; HO Yang; Robert J Linhardt
Chemoenzymatic preparation of dermatan sulfate oligosaccharides as arylsulfatase B and alpha-L-iduronidase substrates.
Glycoconjugate journal 2000;17(12):829-34.
2000: M Koketsu; Balagurunathan Kuberan; Robert J Linhardt
Stereoselective synthesis of the alpha-glycoside of a KDO "C"-disaccharide.
Organic letters 2000;2(21):3361-3.
2000: HO Yang; Nur Sibel Gunay; Toshihiko Toida; Balagurunathan Kuberan; Guangli Yu; YS Kim; Robert J Linhardt
Preparation and structural determination of dermatan sulfate-derived oligosaccharides.
Glycobiology 2000;10(10):1033-9.
2000: M Hernaiz; Jian Liu; R D Rosenberg; Robert J Linhardt
Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III.
Biochemical and biophysical research communications 2000;276(1):292-7.
2000: Joseph Schlessinger; Alexander N Plotnikov; Omar A Ibrahimi; Anna V Eliseenkova; Brian K Yeh; Avner Yayon; Robert J Linhardt; Moosa Mohammadi
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Molecular cell 2000;6(3):743-50.
2000: M Koketsu; Robert J Linhardt
Electrophoresis for the analysis of acidic oligosaccharides.
Analytical biochemistry 2000;283(2):136-45.
2000: I Kilpelainen; Marko Kaksonen; Taru Kinnunen; H Avikainen; Melissa A Fath; Robert J Linhardt; Erkki Raulo; Heikki Rauvala
Heparin-binding growth-associated molecule contains two heparin-binding beta -sheet domains that are homologous to the thrombospondin type I repeat.
The Journal of biological chemistry 2000;275(18):13564-70.
2000: Qun Wang; M Wolff; T Polat; Y Du; Robert J Linhardt
Inhibition of neuraminidase with neuraminic acid C-glycosides.
Bioorganic & medicinal chemistry letters 2000;10(9):941-4.
2000: Linda M Hiebert; Sandra M Wice; Tilly Ping; Ronald E Hileman; Ishan Capila; Robert J Linhardt
Tissue distribution and antithrombotic activity of unlabeled or 14C-labeled porcine intestinal mucosal heparin following administration to rats by the oral route.
Canadian journal of physiology and pharmacology 2000;78(4):307-20.
1999: Weijun Huang; Allan Matte; Yunge Li; YS Kim; Robert J Linhardt; H Su; Miroslaw Cygler
Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution.
Journal of molecular biology 1999;294(5):1257-69.
1999: Y Park; Guangli Yu; Nur Sibel Gunay; Robert J Linhardt
Purification and characterization of heparan sulphate proteoglycan from bovine brain.
The Biochemical journal 1999;344 Pt 3():723-30.
1999: MW Wolff; David W Murhammer; Donald L Jarvis; Robert J Linhardt
Electrophoretic analysis of glycoprotein glycans produced by lepidopteran insect cells infected with an immediate early recombinant baculovirus encoding mammalian beta1,4-galactosyltransferase.
Glycoconjugate journal 1999;16(12):753-6.
1999: Toshihiko Toida; T Maruyama; Y Ogita; Atsushi Suzuki; Hidenao Toyoda; Toshio Imanari; Robert J Linhardt
Preparation and anticoagulant activity of fully O-sulphonated glycosaminoglycans.
International journal of biological macromolecules 1999;26(4):233-41.
1999: Hari G Garg; P A Joseph; B Taylor Thompson; Charles A Hales; Toshihiko Toida; T Imanari; Ishan Capila; Robert J Linhardt
Effect of fully sulfated glycosaminoglycans on pulmonary artery smooth muscle cell proliferation.
Archives of biochemistry and biophysics 1999;371(2):228-33.
1999: C Amornrut; Toshihiko Toida; Toshio Imanari; Eun-Rhan Woo; H Park; Robert J Linhardt; S J Wu; Yeong Shik Kim
A new sulfated beta-galactan from clams with anti-HIV activity.
Carbohydrate research 1999;321(1-2):121-7.
1999: Melissa A Fath; Victoria A VanderNoot; Ilkka Kilpeläinen; Taru Kinnunen; H Rauvala; Robert J Linhardt
Interaction of soluble and surface-bound heparin binding growth-associated molecule with heparin.
FEBS letters 1999;454(1-2):105-8.
1999: Balagurunathan Kuberan; Nur Sibel Gunay; Jonathan S Dordick; Robert J Linhardt
Preparation and isolation of neoglycoconjugates using biotin-streptavidin complexes.
Glycoconjugate journal 1999;16(6):271-81.
1999: Nur Sibel Gunay; Robert J Linhardt
Heparinoids: structure, biological activities and therapeutic applications.
Planta medica 1999;65(4):301-6.
1999: Ishan Capila; Victoria A VanderNoot; Tanya R Mealy; Barbara A Seaton; Robert J Linhardt
Interaction of heparin with annexin V.
FEBS letters 1999;446(2-3):327-30.
1999: MW Wolff; David W Murhammer; Robert J Linhardt
Release and preparation of intact and unreduced N-linked oligosaccharides from Sf-9 insect cells.
Preparative biochemistry & biotechnology 1999;29(1):1-21.
1999: EE Caldwell; A M Andreasen; M A Blietz; J N Serrahn; Victoria A VanderNoot; Y Park; G Yu; Robert J Linhardt; John M Weiler
Heparin binding and augmentation of C1 inhibitor activity.
Archives of biochemistry and biophysics 1999;361(2):215-22.
1999: Robert J Linhardt; Nur Sibel Gunay
Production and chemical processing of low molecular weight heparins.
Seminars in thrombosis and hemostasis 1999;25 Suppl 3():5-16.
1998: SJ Wu; M W Chun; Kuk Hyun Shin; T Toida; Y Park; Robert J Linhardt; Yeong Shik Kim
Chemical sulfonation and anticoagulant activity of acharan sulfate.
Thrombosis research 1998;92(6):273-81.
1998: Ronald E Hileman; Marshall M Siegel; Keiko Tabei; K Balagurunathan; Robert J Linhardt
Isolation and characterization of beta-cyclodextrin sulfates by preparative gradient polyacrylamide gel electrophoresis, capillary electrophoresis and electrospray ionization - mass spectrometry.
Electrophoresis 1998;19(15):2677-81.
1998: X Wu; Robert J Linhardt
Capillary affinity chromatography and affinity capillary electrophoresis of heparin binding proteins.
Electrophoresis 1998;19(15):2650-3.
1998: Ronald E Hileman; R N Jennings; Robert J Linhardt
Thermodynamic analysis of the heparin interaction with a basic cyclic peptide using isothermal titration calorimetry.
Biochemistry 1998;37(43):15231-7.
1998: Yeong Shik Kim; Mi Young Ahn; SJ Wu; D H Kim; T Toida; L M Teesch; Y Park; G Yu; J Lin; Robert J Linhardt
Determination of the structure of oligosaccharides prepared from acharan sulfate.
Glycobiology 1998;8(9):869-77.
1998: H G Bazin; Ishan Capila; Robert J Linhardt
Conformational study of synthetic delta 4-uronate monosaccharides and glycosaminoglycan-derived disaccharides.
Carbohydrate research 1998;309(2):135-44.
1998: Melissa A Fath; X Wu; Ronald E Hileman; Robert J Linhardt; Mohammed A Kashem; R M Nelson; CD Wright; William W Abraham
Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma.
The Journal of biological chemistry 1998;273(22):13563-9.
1998: Mi Young Ahn; K H Shin; D H Kim; E A Jung; T Toida; Robert J Linhardt; Yeong Shik Kim
Characterization of a Bacteroides species from human intestine that degrades glycosaminoglycans.
Canadian journal of microbiology 1998;44(5):423-9.
1998: X Wu; D Loganathan; Robert J Linhardt
Sensitive method for the quantification of beta-glucuronidase activity in human urine using capillary electrophoresis with fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1998;708(1-2):61-6.
1998: Victoria A VanderNoot; Ronald E Hileman; Jonathan S Dordick; Robert J Linhardt
Affinity capillary electrophoresis employing immobilized glycosaminoglycan to resolve heparin-binding peptides.
Electrophoresis 1998;19(3):437-41.
1998: Ronald E Hileman; JR Fromm; John M Weiler; Robert J Linhardt
Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(2):156-67.
1998: T Maruyama; Toshihiko Toida; Toshio Imanari; G Yu; Robert J Linhardt
Conformational changes and anticoagulant activity of chondroitin sulfate following its O-sulfonation.
Carbohydrate research 1998;306(1-2):35-43.
1997: Toshihiko Toida; M Shima; S Azumaya; T Maruyama; Hidenao Toyoda; Toshio Imanari; Robert J Linhardt
Detection of glycosaminoglycans as a copper(II) complex in high-performance liquid chromatography.
Journal of chromatography. A 1997;787(1-2):266-70.
1997: JR Fromm; Ronald E Hileman; John M Weiler; Robert J Linhardt
Interaction of fibroblast growth factor-1 and related peptides with heparan sulfate and its oligosaccharides.
Archives of biochemistry and biophysics 1997;346(2):252-62.
1997: Toshihiko Toida; Y Huang; Y Washio; T Maruyama; Hidenao Toyoda; Toshio Imanari; Robert J Linhardt
Chemical microdetermination of heparin in plasma.
Analytical biochemistry 1997;251(2):219-26.
1997: V D Nadkarni; Robert J Linhardt
Directional immobilization of heparin onto the nonporous surface of polystyrene microplates.
BioTechniques 1997;23(3):382-5.
1997: Y Chen; T Maguire; Ronald E Hileman; JR Fromm; J D Esko; Robert J Linhardt; Rory M Marks
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate.
Nature medicine 1997;3(8):866-71.
1997: J Choe; Victoria A VanderNoot; Robert J Linhardt; Jonathan S Dordick
Parameters affecting the efficiency of affinity-based reversed micellar extraction and separation (ARMES) in glycoprotein purification.
Biotechnology progress 1997;13(4):440-5.
1997: Marshall M Siegel; Keiko Tabei; M Z Kagan; I R Vlahov; Ronald E Hileman; Robert J Linhardt
Polysulfated carbohydrates analyzed as ion-paired complexes with basic peptides and proteins using electrospray negative ionization mass spectrometry.
Journal of mass spectrometry : JMS 1997;32(7):760-72.
1997: JR Fromm; Ronald E Hileman; EE Caldwell; John M Weiler; Robert J Linhardt
Pattern and spacing of basic amino acids in heparin binding sites.
Archives of biochemistry and biophysics 1997;343(1):92-100.
1997: H Wang; Toshihiko Toida; Y S Kim; Ishan Capila; Ronald E Hileman; Merton Bernfield; Robert J Linhardt
Glycosaminoglycans can influence fibroblast growth factor-2 mitogenicity without significant growth factor binding.
Biochemical and biophysical research communications 1997;235(2):369-73.
1997: Ronald E Hileman; A E Smith; Toshihiko Toida; Robert J Linhardt
Preparation and structure of heparin lyase-derived heparan sulfate oligosaccharides.
Glycobiology 1997;7(2):231-9.
1997: Toshihiko Toida; H Yoshida; Hidenao Toyoda; Ichiro Koshiishi; Toshio Imanari; Ronald E Hileman; JR Fromm; Robert J Linhardt
Structural differences and the presence of unsubstituted amino groups in heparan sulphates from different tissues and species.
The Biochemical journal 1997;322 ( Pt 2)():499-506.
1997: Y Park; S Cho; Robert J Linhardt
Exploration of the action pattern of Streptomyces hyaluronate lyase using high-resolution capillary electrophoresis.
Biochimica et biophysica acta 1997;1337(2):217-26.
1997: A M Dougher; H Wasserstrom; L Torley; L Shridaran; P Westdock; Ronald E Hileman; JR Fromm; R Anderberg; S Lyman; Robert J Linhardt; J Kaplan; B I Terman
Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor.
Growth factors (Chur, Switzerland) 1997;14(4):257-68.
1996: Toshihiko Toida; Ronald E Hileman; AE Smith; P I Vlahova; Robert J Linhardt
Enzymatic preparation of heparin oligosaccharides containing antithrombin III binding sites.
The Journal of biological chemistry 1996;271(50):32040-7.
1996: V D Nadkarni; Toshihiko Toida; C L Van Gorp; R L Schubert; John M Weiler; K P Hansen; EE Caldwell; Robert J Linhardt
Preparation and biological activity of N-sulfonated chondroitin and dermatan sulfate derivatives.
Carbohydrate research 1996;290(1):87-96.
1996: D Mikhailov; Kevin H Mayo; I R Vlahov; T Toida; A Pervin; Robert J Linhardt
NMR solution conformation of heparin-derived tetrasaccharide.
The Biochemical journal 1996;318 ( Pt 1)():93-102.
1996: Yeong Shik Kim; Y Y Jo; Il-Moo Chang; T Toida; Y Park; Robert J Linhardt
A new glycosaminoglycan from the giant African snail Achatina fulica.
The Journal of biological chemistry 1996;271(20):11750-5.
1996: D Mikhailov; Kevin H Mayo; A Pervin; Robert J Linhardt
13C-NMR relation study of heparin-disaccharide interactions with tripeptides GRG and GKG.
The Biochemical journal 1996;315 ( Pt 2)():447-54.
1996: T Toida; Robert J Linhardt
Detection of glycosaminoglycans as a copper (II) complex in capillary electrophoresis.
Electrophoresis 1996;17(2):341-6.
1996: EE Caldwell; V D Nadkarni; JR Fromm; Robert J Linhardt; John M Weiler
Importance of specific amino acids in protein binding sites for heparin and heparan sulfate.
The international journal of biochemistry & cell biology 1996;28(2):203-16.
1996: Robert J Linhardt; A Pervin
Separation of negatively charged carbohydrates by capillary electrophoresis.
Journal of chromatography. A 1996;720(1-2):323-35.
1996: K A Jandik; D Kruep; M Cartier; Robert J Linhardt
Accelerated stability studies of heparin.
Journal of pharmaceutical sciences 1996;85(1):45-51.
1995: Jian Liu; U R Desai; X J Han; Toshihiko Toida; Robert J Linhardt
Strategy for the sequence analysis of heparin.
Glycobiology 1995;5(8):765-74.
1995: K Gu; Robert J Linhardt; M Laliberté; K Gu; J Zimmermann
Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum.
The Biochemical journal 1995;312 ( Pt 2)():569-77.
1995: JR Fromm; Ronald E Hileman; EE Caldwell; John M Weiler; Robert J Linhardt
Differences in the interaction of heparin with arginine and lysine and the importance of these basic amino acids in the binding of heparin to acidic fibroblast growth factor.
Archives of biochemistry and biophysics 1995;323(2):279-87.
1995: C C Griffin; Robert J Linhardt; C L Van Gorp; Toshihiko Toida; Ronald E Hileman; R L Schubert; S E Brown
Isolation and characterization of heparan sulfate from crude porcine intestinal mucosal peptidoglycan heparin.
Carbohydrate research 1995;276(1):183-97.
1995: U R Desai; I R Vlahov; A Pervin; Robert J Linhardt
Conformational analysis of sucrose octasulfate by high resolution nuclear magnetic resonance spectroscopy.
Carbohydrate research 1995;275(2):391-401.
1995: R J Kerns; Robert J Linhardt
Separation of hydroxyl protected heparin derived disaccharides using reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 1995;705(2):369-73.
1995: Robert J Linhardt; X J Han; JR Fromm
Lectin affinity electrophoresis.
Molecular biotechnology 1995;3(3):191-7.
1995: V D Nadkarni; Robert J Linhardt
Modified assay for the measurement of biotin in the presence of heparin.
Analytical biochemistry 1995;227(2):402-4.
1995: Robert J Linhardt; Ronald E Hileman
Dermatan sulfate as a potential therapeutic agent.
General pharmacology 1995;26(3):443-51.
1995: Y S Kim; Jian Liu; X J Han; A Pervin; Robert J Linhardt
Analysis of fluorescently labeled sugars by reversed-phase ion-pairing high-performance liquid chromatography.
Journal of chromatographic science 1995;33(4):162-7.
1995: R E Edens; JR Fromm; S J Fromm; Robert J Linhardt; John M Weiler
Two-dimensional affinity resolution electrophoresis demonstrates that three distinct heparin populations interact with antithrombin III.
Biochemistry 1995;34(8):2400-7.
1995: A Pervin; C Gallo; K A Jandik; X J Han; Robert J Linhardt
Preparation and structural characterization of large heparin-derived oligosaccharides.
Glycobiology 1995;5(1):83-95.
1995: U R Desai; Robert J Linhardt
Molecular weight of heparin using 13C nuclear magnetic resonance spectroscopy.
Journal of pharmaceutical sciences 1995;84(2):212-5.
1995: R J Kerns; I R Vlahov; Robert J Linhardt
Capillary electrophoresis for monitoring chemical reactions: sulfation and synthetic manipulation of sulfated carbohydrates.
Carbohydrate research 1995;267(1):143-52.
1994: V D Nadkarni; A Pervin; Robert J Linhardt
Directional immobilization of heparin onto beaded supports.
Analytical biochemistry 1994;222(1):59-67.
1994: A Pervin; A al-Hakim; Robert J Linhardt
Separation of glycosaminoglycan-derived oligosaccharides by capillary electrophoresis using reverse polarity.
Analytical biochemistry 1994;221(1):182-8.
1994: J Bae; U R Desai; A Pervin; EE Caldwell; John M Weiler; Robert J Linhardt
Interaction of heparin with synthetic antithrombin III peptide analogues.
The Biochemical journal 1994;301 ( Pt 1)():121-9.
1994: Jian Liu; A Pervin; C M Gallo; U R Desai; C L Van Gorp; Robert J Linhardt
New approaches for the preparation of hydrophobic heparin derivatives.
Journal of pharmaceutical sciences 1994;83(7):1034-9.
1994: K A Jandik; K Gu; Robert J Linhardt
Action pattern of polysaccharide lyases on glycosaminoglycans.
Glycobiology 1994;4(3):289-96.
1994: Robert J Linhardt; U R Desai; Jian Liu; A Pervin; D Hoppensteadt; J Fareed
Low molecular weight dermatan sulfate as an antithrombotic agent. Structure-activity relationship studies.
Biochemical pharmacology 1994;47(7):1241-52.
1994: U R Desai; Robert J Linhardt
Molecular weight of low molecular weight heparins by 13C nuclear magnetic resonance spectroscopy.
Carbohydrate research 1994;255():193-212.
1994: R E Edens; Robert J Linhardt; C S Bell; John M Weiler
Heparin and derivatized heparin inhibit zymosan and cobra venom factor activation of complement in serum.
Immunopharmacology 1994;27(2):145-53.
1994: Robert J Linhardt
Capillary electrophoresis of oligosaccharides.
Methods in enzymology 1994;230():265-80.
1993: U R Desai; H M Wang; Robert J Linhardt
Substrate specificity of the heparin lyases from Flavobacterium heparinum.
Archives of biochemistry and biophysics 1993;306(2):461-8.
1993: U R Desai; H M Wang; Robert J Linhardt
Specificity studies on the heparin lyases from Flavobacterium heparinum.
Biochemistry 1993;32(32):8140-5.
1993: U R Desai; H Wang; S A Ampofo; Robert J Linhardt
Oligosaccharide composition of heparin and low-molecular-weight heparins by capillary electrophoresis.
Analytical biochemistry 1993;213(1):120-7.
1993: K Gu; Jian Liu; A Pervin; Robert J Linhardt
Comparison of the activity of two chondroitin AC lyases on dermatan sulfate.
Carbohydrate research 1993;244(2):369-77.
1993: U R Desai; H M Wang; T R Kelly; Robert J Linhardt
Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin.
Carbohydrate research 1993;241():249-59.
1993: K Gu; R E Edens; K A Jandik; Robert J Linhardt
Monoclonal antibodies prepared against heparin lyase I and their reactivity toward heparin lyase I, II and III.
The International journal of biochemistry 1993;25(3):331-6.
1993: E A Schmitt; Douglas R Flanagan; Robert J Linhardt
Degradation and release properties of pellets fabricated from three commercial poly(D,L-lactide-co-glycolide) biodegradable polymers.
Journal of pharmaceutical sciences 1993;82(3):326-9.
1993: A Pervin; K Gu; Robert J Linhardt
Capillary electrophoresis to measure sulfoesterase activity on chondroitin sulfate and heparin derived disaccharides.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society 1993;3(6):297-303.
1992: Robert J Linhardt; S A Ampofo; J Fareed; D Hoppensteadt; J B Mulliken; J Folkman
Isolation and characterization of human heparin.
Biochemistry 1992;31(49):12441-5.
1992: D L Lohse; Robert J Linhardt
Purification and characterization of heparin lyases from Flavobacterium heparinum.
The Journal of biological chemistry 1992;267(34):24347-55.
1992: K B Lee; U R Desai; Monica Palcic; O Hindsgaul; Robert J Linhardt
An electrophoresis-based assay for glycosyltransferase activity.
Analytical biochemistry 1992;205(1):108-14.
1992: R E Edens; A al-Hakim; John M Weiler; D G Rethwisch; J Fareed; Robert J Linhardt
Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular-weight heparin derivatives.
Journal of pharmaceutical sciences 1992;81(8):823-7.
1992: K B Lee; Y S Kim; Robert J Linhardt
Lectin affinity electrophoresis for the separation of fluorescently labeled sugar derivatives.
Analytical biochemistry 1992;203(2):206-10.
1992: John M Weiler; R E Edens; Robert J Linhardt; D P Kapelanski
Heparin and modified heparin inhibit complement activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3210-5.
1992: Robert J Linhardt; H M Wang; D Loganathan; D J Lamb; L M Mallis
Analysis of glycosaminoglycan-derived oligosaccharides using fast-atom-bombardment mass-spectrometry.
Carbohydrate research 1992;225(1):137-45.
1992: Robert J Linhardt; H M Wang; D Loganathan; J H Bae
Search for the heparin antithrombin III-binding site precursor.
The Journal of biological chemistry 1992;267(4):2380-7.
1992: Robert J Linhardt; H M Wang; S A Ampofo
New methodologies in heparin structure analysis and the generation of LMW heparins.
Advances in experimental medicine and biology 1992;313():37-47.
1991: S A Ampofo; H M Wang; Robert J Linhardt
Disaccharide compositional analysis of heparin and heparan sulfate using capillary zone electrophoresis.
Analytical biochemistry 1991;199(2):249-55.
1991: Robert J Linhardt; A al-Hakim; J A Liu; D Hoppensteadt; Giuseppe Mascellani; P Bianchini; J Fareed
Structural features of dermatan sulfates and their relationship to anticoagulant and antithrombotic activities.
Biochemical pharmacology 1991;42(8):1609-19.
1991: H M Wang; D Loganathan; Robert J Linhardt
Determination of the pKa of glucuronic acid and the carboxy groups of heparin by 13C-nuclear-magnetic-resonance spectroscopy.
The Biochemical journal 1991;278 ( Pt 3)():689-95.
1991: K B Lee; Y S Kim; Robert J Linhardt
Capillary zone electrophoresis for the quantitation of oligosaccharides formed through the action of chitinase.
Electrophoresis 1991;12(9):636-40.
1991: K B Lee; A al-Hakim; D Loganathan; Robert J Linhardt
A new method for sequencing linear oligosaccharides on gels using charged, fluorescent conjugates.
Carbohydrate research 1991;214(1):155-68.
1991: A al-Hakim; Robert J Linhardt
Capillary electrophoresis for the analysis of chondroitin sulfate- and dermatan sulfate-derived disaccharides.
Analytical biochemistry 1991;195(1):68-73.
1991: Robert J Linhardt; A al-Hakim; S Y Liu; Y S Kim; J Fareed
Molecular profile and mapping of dermatan sulfates from different origins.
Seminars in thrombosis and hemostasis 1991;17 Suppl 1():15-22.
1991: A al-Hakim; Robert J Linhardt
Electrophoresis and detection of nanogram quantities of exogenous and endogenous glycosaminoglycans in biological fluids.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society 1991;1(6):305-12.
1990: D L Gordon; Robert J Linhardt; Harold P Adams
Low-molecular-weight heparins and heparinoids and their use in acute or progressing ischemic stroke.
Clinical neuropharmacology 1990;13(6):522-43.
1990: R E Edens; Robert J Linhardt; John M Weiler
Immobilization of C3b with retention of functional activity.
Journal of immunological methods 1990;133(1):67-70.
1990: Robert J Linhardt; D Loganathan; A al-Hakim; H M Wang; J M Walenga; D Hoppensteadt; J Fareed
Oligosaccharide mapping of low molecular weight heparins: structure and activity differences.
Journal of medicinal chemistry 1990;33(6):1639-45.
1990: D Loganathan; H M Wang; L M Mallis; Robert J Linhardt
Structural variation in the antithrombin III binding site region and its occurrence in heparin from different sources.
Biochemistry 1990;29(18):4362-8.
1990: Robert J Linhardt; J E Turnbull; H M Wang; D Loganathan; J T Gallagher
Examination of the substrate specificity of heparin and heparan sulfate lyases.
Biochemistry 1990;29(10):2611-7.
1990: Robert J Linhardt; N C Baenziger; B Ronsen
Structure of amiprilose hydrochloride, a novel anti-inflammatory agent.
Journal of pharmaceutical sciences 1990;79(2):158-62.
1990: K B Lee; D Loganathan; Z M Merchant; Robert J Linhardt
Carbohydrate analysis of glycoproteins. A review.
Applied biochemistry and biotechnology 1990;23(1):53-80.
1990: D M Cohen; Robert J Linhardt
Randomness in the heparin polymer: computer simulations of alternative action patterns of heparin lyase.
Biopolymers 1990;30(7-8):733-41.
1990: A al-Hakim; Robert J Linhardt
Isolation and recovery of acidic oligosaccharides from polyacrylamide gels by semi-dry electrotransfer.
Electrophoresis 1990;11(1):23-8.
1989: Robert J Linhardt; K N Gu; D Loganathan; S R Carter
Analysis of glycosaminoglycan-derived oligosaccharides using reversed-phase ion-pairing and ion-exchange chromatography with suppressed conductivity detection.
Analytical biochemistry 1989;181(2):288-96.
1989: K G Rice; Robert J Linhardt
Study of structurally defined oligosaccharide substrates of heparin and heparan monosulfate lyases.
Carbohydrate research 1989;190(2):219-33.
1989: Robert J Linhardt; D M Cohen; K G Rice
Nonrandom structural features in the heparin polymer.
Biochemistry 1989;28(7):2888-94.
1989: John M Weiler; Robert J Linhardt
Comparison of the activity of polyanions and polycations on the classical and alternative pathways of complement.
Immunopharmacology 1989;17(2):65-72.
1989: José Biller; E W Massey; John R Marler; Harold P Adams; J N Davis; A Bruno; R A Henriksen; Robert J Linhardt; L B Goldstein; M Alberts
A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke.
Neurology 1989;39(2 Pt 1):262-5.
1989: Y S Kim; Robert J Linhardt
Structural features of heparin and their effect on heparin cofactor II mediated inhibition of thrombin.
Thrombosis research 1989;53(1):55-71.
1988: Robert J Linhardt; K G Rice; Y S Kim; J D Engelken; John M Weiler
Homogeneous, structurally defined heparin-oligosaccharides with low anticoagulant activity inhibit the generation of the amplification pathway C3 convertase in vitro.
The Journal of biological chemistry 1988;263(26):13090-6.
1988: Robert J Linhardt; K G Rice; Y S Kim; D L Lohse; H M Wang; D Loganathan
Mapping and quantification of the major oligosaccharide components of heparin.
The Biochemical journal 1988;254(3):781-7.
1988: Y S Kim; K B Lee; Robert J Linhardt
Microheterogeneity of plasma glycoproteins heparin cofactor II and antithrombin III and their carbohydrate analysis.
Thrombosis research 1988;51(1):97-104.
1987: Robert J Linhardt
Bioassays. Patents and literature.
Applied biochemistry and biotechnology 1987;15(3):279-95.
1987: K G Rice; M K Rottink; Robert J Linhardt
Fractionation of heparin-derived oligosaccharides by gradient polyacrylamide-gel electrophoresis.
The Biochemical journal 1987;244(3):515-22.
1987: Robert J Linhardt
Monoclonal antibodies and immobilized antibodies. Patents and literature.
Applied biochemistry and biotechnology 1987;15(1):53-80.
1987: Robert J Linhardt; R Langer
New approaches for anticoagulation in extracorporeal therapy.
Biomaterials, artificial cells, and artificial organs 1987;15(1):91-100.
1986: Robert J Linhardt; K G Rice; Z M Merchant; Y S Kim; D L Lohse
Structure and activity of a unique heparin-derived hexasaccharide.
The Journal of biological chemistry 1986;261(31):14448-54.
1985: Robert J Linhardt; Z M Merchant; K G Rice; Y S Kim; G L Fitzgerald; A C Grant; R Langer
Evidence of random structural features in the heparin polymer.
Biochemistry 1985;24(26):7805-10.
1985: K G Rice; Y S Kim; A C Grant; Z M Merchant; Robert J Linhardt
High-performance liquid chromatographic separation of heparin-derived oligosaccharides.
Analytical biochemistry 1985;150(2):325-31.
1985: Z M Merchant; Y S Kim; K G Rice; Robert J Linhardt
Structure of heparin-derived tetrasaccharides.
The Biochemical journal 1985;229(2):369-77.
1985: M D Sharath; Z M Merchant; Y S Kim; K G Rice; Robert J Linhardt; John M Weiler
Small heparin fragments regulate the amplification pathway of complement.
Immunopharmacology 1985;9(2):73-80.
1984: A C Grant; Robert J Linhardt; G L Fitzgerald; J J Park; R Langer
Metachromatic activity of heparin and heparin fragments.
Analytical biochemistry 1984;137(1):25-32.