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Daniel Link

Research Profile

Chemicals & Drugs

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Hematopoietic Stem Cell Mobilization

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TOP 3
Adam Greenbaum; Yen-Michael S Hsu; Joshua N Borgerding; Matthew J Christopher; Ryan B Day; Takashi Nagasawa; Laura G Schuettpelz; Daniel C Link
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.
Daniel C Link
Osteocytes link bone maintenance to blood homeostasis.
Daniel C Link
Molecular genetics of AML.

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All Publications

2013: Adam Greenbaum; Yen-Michael S Hsu; Joshua N Borgerding; Matthew J Christopher; Ryan B Day; Takashi Nagasawa; Laura G Schuettpelz; Daniel C Link
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.
Nature 2013;495(7440):227-30.
2013: Daniel C Link
Osteocytes link bone maintenance to blood homeostasis.
Blood 2013;121(6):867-8.
2012: Daniel C Link
Molecular genetics of AML.
Best practice & research. Clinical haematology 2012;25(4):409-14.
2012: Laura G Schuettpelz; Ronald van Os; Felipe O Giuste; Priya K Gopalan; Molly P Romine; Daniel C Link
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood 2012;120(15):2981-9.
2012: Adam M Greenbaum; Leila D Revollo; Jill R Woloszynek; Roberto Civitelli; Daniel C Link
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.
Blood 2012;120(2):295-302.
2012: Ryan B Day; Daniel C Link
Regulation of neutrophil trafficking from the bone marrow.
Cellular and molecular life sciences : CMLS 2012;69(9):1415-23.
2012: Matthew J Walter; Peter Westervelt; Richard K Wilson; Sarah Witowski; Rachel Abbott; Ken Chen; Li Ding; John F DiPersio; David Dooling; William Eades; Xian Fan; John L Frater; Robert Fulton; Marcus Grillot; Sharon Heath; Joelle Kalicki-Veizer; Daniel C Koboldt; David E Larson; Timothy J Ley; Daniel C Link; vincent magrini; Elaine R Mardis; Michael D McLellan; Michelle O'Laughlin; Heather Schmidt; Jin Shao; Dong Shen; Michael H Tomasson; Timothy A Graubert
Clonal architecture of secondary acute myeloid leukemia.
The New England journal of medicine 2012;366(12):1090-8.
2011: Ghada Kunter; Jill R Woloszynek; Daniel C Link
A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice.
Experimental hematology 2011;39(12):1136-43.
2011: John S Welch; Peter Westervelt; Li Ding; David E Larson; Jeffery M Klco; Shashikant Kulkarni; John Wallis; Ken Chen; Jacqueline E Payton; Robert S Fulton; Joelle Veizer; Heather Schmidt; Tammi L Vickery; Sharon Heath; Mark A Watson; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Timothy J Ley; Richard K Wilson
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.
JAMA : the journal of the American Medical Association 2011;305(15):1577-84.
2011: Matthew J Christopher; Mahil Rao; Fulu Liu; Jill R Woloszynek; Daniel C Link
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.
The Journal of experimental medicine 2011;208(2):251-60.
2011: A M Greenbaum; Daniel C Link
Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization.
Leukemia 2011;25(2):211-7.
2010: Giridharan Ramsingh; Daniel C Koboldt; Maria Trissal; Katherine B Chiappinelli; Todd Wylie; Sunita Koul; Li-Wei Chang; Rakesh Nagarajan; Todd A Fehniger; Paul Goodfellow; vincent magrini; Richard K Wilson; Li Ding; Timothy J Ley; Elaine R Mardis; Daniel C Link
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Blood 2010;116(24):5316-26.
2010: Todd A Fehniger; Todd Wylie; Elizabeth Germino; Jeffrey W Leong; vincent magrini; Sunita Koul; Catherine R Keppel; Stephanie E Schneider; Daniel C Koboldt; Ryan P Sullivan; Michael E Heinz; Seth D Crosby; Rakesh Nagarajan; Giridharan Ramsingh; Daniel C Link; Timothy J Ley; Elaine R Mardis
Next-generation sequencing identifies the natural killer cell microRNA transcriptome.
Genome research 2010;20(11):1590-604.
2010: Kyle J Eash; Adam M Greenbaum; Priya K Gopalan; Daniel C Link
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow.
The Journal of clinical investigation 2010;120(7):2423-31.
2010: Philip S Rosenberg; Cornelia Zeidler; Audrey Anna Bolyard; BLANCHE ALTER; Mary Ann Bonilla; Laurence A Boxer; Yigal Dror; Sally Kinsey; Daniel C Link; Peter E Newburger; Akiko Shimamura; Karl Welte; David C Dale
Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy.
British journal of haematology 2010;150(2):196-9.
2010: Alyssa D Gregory; Benjamin J Capoccia; Jill R Woloszynek; Daniel C Link
Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes.
Journal of leukocyte biology 2010;88(1):123-31.
2009: Jun Xia; Audrey Anna Bolyard; Elin Rodger; Steve Stein; Andrew A Aprikyan; David C Dale; Daniel C Link
Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia.
British journal of haematology 2009;147(4):535-42.
2009: Matthew J Christopher; Fulu Liu; Matthew J Hilton; Fanxin Long; Daniel C Link
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.
Blood 2009;114(7):1331-9.
2009: Matthew J Walter; Jacqueline E Payton; Rhonda E Ries; William D Shannon; Hrishikesh Deshmukh; Yu Zhao; Jack Baty; Sharon Heath; Peter Westervelt; Mark A Watson; Michael H Tomasson; Rakesh Nagarajan; Brian P O'Gara; Clara D Bloomfield; Krzysztof Mrózek; Rebecca R Selzer; Richmond Todd; Jacob Kitzman; Joel Geoghegan; Peggy S Eis; Rachel Maupin; Robert S Fulton; Michael D McLellan; Richard K Wilson; Elaine R Mardis; Daniel C Link; Timothy A Graubert; John F DiPersio; Timothy J Ley
Acquired copy number alterations in adult acute myeloid leukemia genomes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12950-5.
2009: Mike G Martin; Jacqueline E Payton; Daniel C Link
Dicer and outcomes in patients with acute myeloid leukemia (AML).
Leukemia research 2009;33(8):e127.
2009: Jacqueline E Payton; Nicole R Grieselhuber; Li-Wei Chang; Mark Murakami; Gary K Geiss; Daniel C Link; Rakesh Nagarajan; Mark A Watson; Timothy J Ley
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.
The Journal of clinical investigation 2009;119(6):1714-26.
2009: Benjamin J Capoccia; Debra L Robson; Krysta D Levac; Dustin J Maxwell; Sarah A Hohm; Marian J Neelamkavil; Gillian I Bell; Anargyros Xenocostas; Daniel C Link; David Piwnica-Worms; Jan A Nolta; David A Hess
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.
Blood 2009;113(21):5340-51.
2008: Zhifu Xiang; Zhifu Xiang; Richard Walgren; Yu Zhao; Yumi Kasai; Tracie Miner; Rhonda E Ries; Olga Lubman; daved fremont; Michael D McLellan; Jacqueline E Payton; Peter Westervelt; John F DiPersio; Daniel C Link; Matthew J Walter; Timothy A Graubert; Mark Watson; Jack Baty; Sharon Heath; William D Shannon; Rakesh Nagarajan; Clara D Bloomfield; Elaine R Mardis; Richard K Wilson; Timothy J Ley
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Blood 2008;111(9):4797-808.
2008: Zhifu Xiang; Yu Zhao; Vesselin Mitaksov; daved fremont; Yumi Kasai; AnnaLynn Molitoris; Rhonda E Ries; Tracie L Miner; Michael D McLellan; John F DiPersio; Daniel C Link; Jacqueline E Payton; Timothy A Graubert; Mark Watson; William Shannon; Sharon E Heath; Rakesh Nagarajan; Elaine R Mardis; Richard K Wilson; Timothy J Ley; Zhifu Xiang
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
Blood 2008;111(9):4809-12.
2008: Fulu Liu; Ghada Kunter; Maxwell M Krem; William C Eades; Jennifer A Cain; Michael H Tomasson; Lothar Hennighausen; Daniel C Link
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.
The Journal of clinical investigation 2008;118(3):946-55.
2008: Jun Xia; Daniel C Link
Severe congenital neutropenia and the unfolded protein response.
Current opinion in hematology 2008;15(1):1-7.
2008: Philip S Rosenberg; BLANCHE ALTER; Daniel C Link; Steven Stein; Elin Rodger; Audrey Anna Bolyard; Andrew A G Aprikyan; Mary Ann Bonilla; Yigal Dror; George Kannourakis; Peter E Newburger; Laurence A Boxer; David C Dale
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia.
British journal of haematology 2008;140(2):210-3.
2007: David S Grenda; Mark Murakami; Jhuma Ghatak; Jun Xia; Laurence A Boxer; David Dale; Mary C Dinauer; Daniel C Link
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.
Blood 2007;110(13):4179-87.
2007: Amy S Rawls; Alyssa D Gregory; Jill R Woloszynek; Fulu Liu; Daniel C Link
Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential.
Blood 2007;110(7):2414-22.
2007: Daniel C Link; Ghada Kunter; Yumi Kasai; Yu Zhao; Tracie Miner; Michael D McLellan; Rhonda E Ries; Deepak Kapur; Rakesh Nagarajan; David C Dale; Audrey Anna Bolyard; Laurence A Boxer; Karl Welte; Cornelia Zeidler; jean donadieu; Christine Bellanné-Chantelot; James W Vardiman; Michael A Caligiuri; Clara D Bloomfield; John F DiPersio; Michael H Tomasson; Timothy A Graubert; Peter Westervelt; Mark Watson; William D Shannon; Jack Baty; Elaine R Mardis; Richard K Wilson; Timothy J Ley
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.
Blood 2007;110(5):1648-55.
2007: Alyssa D Gregory; Lisa A Hogue; Thomas Ferkol; Daniel C Link
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
Blood 2007;109(8):3235-43.
2007: Wenlin Yuan; Jacqueline E Payton; Matthew S Holt; Daniel C Link; Mark A Watson; John F DiPersio; Timothy J Ley
Commonly dysregulated genes in murine APL cells.
Blood 2007;109(3):961-70.
2007: Matthew J Christopher; Daniel C Link
Regulation of neutrophil homeostasis.
Current opinion in hematology 2007;14(1):3-8.
2006: Rebecca M Shepherd; Benjamin J Capoccia; Steven M Devine; John Dipersio; Kathryn Trinkaus; David Ingram; Daniel C Link
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100.
Blood 2006;108(12):3662-7.
2006: Hasan Güven; Rebecca M Shepherd; Richard G Bach; Benjamin J Capoccia; Daniel C Link
The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease.
Journal of the American College of Cardiology 2006;48(8):1579-87.
2006: Bruno Nervi; Daniel C Link; John F DiPersio
Cytokines and hematopoietic stem cell mobilization.
Journal of cellular biochemistry 2006;99(3):690-705.
2006: Craig H Mermel; Morgan L McLemore; Fulu Liu; Shalini Pereira; Jill R Woloszynek; Clifford A Lowell; Daniel C Link
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.
Blood 2006;108(8):2562-8.
2006: Benjamin J Capoccia; Rebecca M Shepherd; Daniel C Link
G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism.
Blood 2006;108(7):2438-45.
2006: Arati Khanna-Gupta; Hong Sun; Theresa Zibello; Larissa Lozovatsky; Prabhat K Ghosh; Daniel C Link; Morgan L McLemore; Nancy Berliner
p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation.
Journal of leukocyte biology 2006;79(5):1011-21.
2006: David S Grenda; Daniel C Link
5. Mechanisms of disordered granulopoiesis in congenital neutropenia.
Current topics in developmental biology 2006;74():133-76.
2005: Craig L Semerad; Matthew J Christopher; Fulu Liu; Brenton Short; Paul J Simmons; Ingrid Winkler; Jean-Pierre Levesque; Jean Chappel; F Patrick Ross; Daniel C Link
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.
Blood 2005;106(9):3020-7.
2005: Daniel C Link
Neutrophil homeostasis: a new role for stromal cell-derived factor-1.
Immunologic research 2005;32(1-3):169-78.
2005: David S Grenda; Daniel C Link
Neutrophil differentiation.
Haematologica 2005;90(1):2.
2004: Jill R Woloszynek; Robert J Rothbaum; Amy S Rawls; Patrick J Minx; Richard K Wilson; Philip Mason; Monica Bessler; Daniel C Link
Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome.
Blood 2004;104(12):3588-90.
2004: Jean-Pierre Levesque; Fulu Liu; Paul J Simmons; Tomoko Betsuyaku; Robert M Senior; Christine Pham; Daniel C Link
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Blood 2004;104(1):65-72.
2004: Bing Han; Jacqueline Unsinger; Fulu Liu; Daniel C Link; Monica Bessler
G-CSF induced progenitor mobilization in mice with PIGA- blood cells.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(4):347-52.
2003: Timothy J Ley; Patrick J Minx; Matthew J Walter; Rhonda E Ries; Hui Sun; Michael D McLellan; John F DiPersio; Daniel C Link; Michael H Tomasson; Timothy A Graubert; howard mcleod; Hanna Khoury; Mark Watson; William D Shannon; Kathryn Trinkaus; Sharon Heath; James W Vardiman; Michael A Caligiuri; Clara D Bloomfield; Jeffrey D Milbrandt; Elaine R Mardis; Richard K Wilson
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14275-80.
2003: Michael K Richards; Fulu Liu; Hiromi Iwasaki; Koichi Akashi; Daniel C Link
Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway.
Blood 2003;102(10):3562-8.
2003: James W Watters; Ellen F Kloss; Daniel C Link; Timothy A Graubert; howard mcleod
A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(4):1352-60.
2002: David S Grenda; Sonja E Johnson; Jill R Mayer; Morgan L McLemore; Kathleen F Benson; Marshall Horwitz; Daniel C Link
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.
Blood 2002;100(9):3221-8.
2002: Craig L Semerad; Fulu Liu; Alyssa D Gregory; Katherine Stumpf; Daniel C Link
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood.
Immunity 2002;17(4):413-23.
2002: John Thomas; Fulu Liu; Daniel C Link
Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor.
Current opinion in hematology 2002;9(3):183-9.
2001: Morgan L McLemore; S Grewal; Fulu Liu; A Archambault; J Poursine-Laurent; JS Haug; Daniel C Link
STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation.
Immunity 2001;14(2):193-204.
2000: Fulu Liu; J Poursine-Laurent; Daniel C Link
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF.
Blood 2000;95(10):3025-31.
2000: Daniel C Link
Mechanisms of granulocyte colony-stimulating factor-induced hematopoietic progenitor-cell mobilization.
Seminars in hematology 2000;37(1 Suppl 2):25-32.
1999: Craig L Semerad; J Poursine-Laurent; Fulu Liu; Daniel C Link
A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.
Immunity 1999;11(2):153-61.
1999: Tomoko Betsuyaku; Fulu Liu; Robert M Senior; JS Haug; E J Brown; S L Jones; K Matsushima; Daniel C Link
A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation.
The Journal of clinical investigation 1999;103(6):825-32.
1998: Morgan L McLemore; J Poursine-Laurent; Daniel C Link
Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.
The Journal of clinical investigation 1998;102(3):483-92.
1998: J Jacob; JS Haug; S Raptis; Daniel C Link
Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF-dependent granulocytic differentiation.
Blood 1998;92(2):353-61.
1997: Fulu Liu; J Poursine-Laurent; H Y Wu; Daniel C Link
Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.
Blood 1997;90(7):2583-90.
1997: Fulu Liu; J Poursine-Laurent; Daniel C Link
The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand.
Blood 1997;90(7):2522-8.
1996: Fulu Liu; H Y Wu; Robin Wesselschmidt; T Kornaga; Daniel C Link
Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice.
Immunity 1996;5(5):491-501.