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Darwin Linthicum

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
5
Bolger, Michael
4
Khare, Sangeeta
4
Gokulan, Kuppan
4
Pledger, David
3
Guddat, Luke
3
Ioerger, Thomas
3
Anchin, JM
3
Burgess, Kevin
3
Edmundson, Allen
3
Shan, Lin
3
Modiano, Jaime
1
Smith, Roger
1
Sotriffer, CA
1
Thanavala, Yasmin
1
Varga, JM

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Publications

TOP 3
Frazer-Abel Ashley A; Baksh Shairaz; Fosmire Susan P; Willis Derall; Pierce Angela M; Meylemans Heather; Linthicum Darwin S; Burakoff Steven J; Coons Teresa; Bellgrau Donald; Modiano Jaime F
Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.
Khare Sangeeta; Banai Yona; Gokulan Kuppan; Smith Roger; Linthicum Darwin S; Modiano Jaime F
Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs.
Linthicum D S; Tetin S Y; Anchin J M; Ioerger T R
Antibody-ligand interactions: computational modeling and correlation with biophysical measurements.

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All Publications

2004: Frazer-Abel Ashley A; Baksh Shairaz; Fosmire Susan P; Willis Derall; Pierce Angela M; Meylemans Heather; Linthicum Darwin S; Burakoff Steven J; Coons Teresa; Bellgrau Donald; Modiano Jaime F
Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.
The Journal of pharmacology and experimental therapeutics 2004;311(2):758-69.
2003: Khare Sangeeta; Banai Yona; Gokulan Kuppan; Smith Roger; Linthicum Darwin S; Modiano Jaime F
Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs.
European journal of pharmacology 2003;465(1-2):23-30.
2001: Linthicum D S; Tetin S Y; Anchin J M; Ioerger T R
Antibody-ligand interactions: computational modeling and correlation with biophysical measurements.
Combinatorial chemistry & high throughput screening 2001;4(5):439-49.
2001: Linthicum D S; Patel J; Cairns N
Antibody-based fluorescence polarization assay to screen combinatorial libraries for sweet taste compounds.
Combinatorial chemistry & high throughput screening 2001;4(5):431-8.
2001: Zhang A J; Khare S; Gokulan K; Linthicum D S; Burgess K
Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC.
Bioorganic & medicinal chemistry letters 2001;11(2):207-10.
2001: Khare S; Gokulan K; Linthicum D S
Cellular responses of NG108-15 and SK-N-MC lines to sweet and bitter tastants as measured by extracellular acidification rates.
Journal of neuroscience research 2001;63(1):64-71.
2000: Modiano J F; Mayor J; Ball C; Fuentes M K; Linthicum D S
CDK4 expression and activity are required for cytokine responsiveness in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6693-702.
2000: Hofle M; Linthicum D S; Ioerger T
Analysis of diversity of nucleotide and amino acid distributions in the VD and DJ joining regions in Ig heavy chains.
Molecular immunology 2000;37(14):827-35.
2000: Guddat L W; Shan L; Broomell C; Ramsland P A; Fan Z; Anchin J M; Linthicum D S; Edmundson A B
The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins.
Journal of molecular biology 2000;302(4):853-72.
2000: Khare S; Gokulan K; Linthicum D S
Vasoactive amine responses in murine cerebrovascular endothelial cells as measured by extracellular acidification rates.
Journal of neuroscience research 2000;60(3):356-61.
1999: Pledger D W; Brodnicki T C; Graham B L; Tetin S; Kranz D M; Linthicum D S
Construction and characterization of two anti-sweetener single chain antibodies using radioligand binding, fluorescence and circular dichroism spectroscopy.
Journal of molecular recognition : JMR 1999;12(4):258-66.
1999: Ioerger T R; Du C; Linthicum D S
Conservation of cys-cys trp structural triads and their geometry in the protein domains of immunoglobulin superfamily members.
Molecular immunology 1999;36(6):373-86.
1998: Lim K; Owens S M; Arnold L; Sacchettini J C; Linthicum D S
Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine.
The Journal of biological chemistry 1998;273(44):28576-82.
1998: Feng Y; Burgess K; Pledger D; Cairns N; Linthicum D S
A labeled guanidine ligand for studying sweet taste.
Bioorganic & medicinal chemistry letters 1998;8(7):881-4.
1997: Yong T; Zheng M Q; Linthicum D S
Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse.
Journal of neuroimmunology 1997;80(1-2):158-64.
1997: Yong T; Zheng M Q; Linthicum D S
Local histamine release increases leukocyte rolling in the cerebral microcirculation of the mouse.
Brain injury : [BI] 1997;11(10):765-74.
1997: Anchin J M; Nagarajan S; Carter J; Kellogg M S; DuBois G E; Linthicum D S
Recognition of superpotent sweetener ligands by a library of monoclonal antibodies.
Journal of molecular recognition : JMR 1997;10(5):235-42.
1997: Burgess K; Li W; Linthicum D S; Ni Q; Pledger D; Rothman R B; Shitangkoon A
Libraries of opiate and anti-opiate peptidomimetics containing 2,3-methanoleucine.
Bioorganic & medicinal chemistry 1997;5(9):1867-71.
1996: Viswanathan M; Subramaniam S; Pledger D W; Tetin S Y; Linthicum D S
Modeling the structure of the combining site of an antisweet taste ligand monoclonal antibody NC10.14.
Biopolymers 1996;39(3):395-406.
1996: Bebo B F; Yong T; Orr E L; Linthicum D S
Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis.
Journal of neuroscience research 1996;45(4):340-8.
1996: Bebo B F; Lee C H; Orr E L; Linthicum D S
Mast cell-derived histamine and tumour necrosis factor: differences between SJL/J and BALB/c inbred strains of mice.
Immunology and cell biology 1996;74(3):225-30.
1996: Yong T; Linthicum D S
Microvascular leakage in mouse pial venules induced by bradykinin.
Brain injury : [BI] 1996;10(5):385-93.
1996: Mandal C; Kingery B D; Anchin J M; Subramaniam S; Linthicum D S
ABGEN: a knowledge-based automated approach for antibody structure modeling.
Nature biotechnology 1996;14(3):323-8.
1996: Carpenter R; Anchin J M; Linthicum D S
Molecular probes for sweeteners: immunorecognition of superpotent guanidinium compounds.
Hybridoma 1996;15(1):17-21.
1996: Sotriffer C A; Liedl K R; Winger R H; Gamper A M; Kroemer R T; Linthicum D S; Rode B M; Varga J M
Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking.
Molecular immunology 1996;33(2):129-44.
1996: Tetin S Y; Linthicum D S
Circular dichroism spectroscopy of monoclonal antibodies that bind a superpotent guanidinium sweetener ligand.
Biochemistry 1996;35(4):1258-64.
1995: Bebo B F; Linthicum D S
Expression of mRNA for 55-kDa and 75-kDa tumor necrosis factor (TNF) receptors in mouse cerebrovascular endothelium: effects of interleukin-1 beta, interferon-gamma and TNF-alpha on cultured cells.
Journal of neuroimmunology 1995;62(2):161-7.
1995: Viswanathan M; Anchin J M; Droupadi P R; Mandal C; Linthicum D S; Subramaniam S
Structural predictions of the binding site architecture for monoclonal antibody NC6.8 using computer-aided molecular modeling, ligand binding, and spectroscopy.
Biophysical journal 1995;69(3):741-53.
1995: Droupadi P R; Linthicum D S
Absorption spectroscopy of the complexation between superpotent guanidinium sweeteners and specific monoclonal antibodies.
The international journal of biochemistry & cell biology 1995;27(4):351-7.
1995: Guddat L W; Shan L; Fan Z C; Andersen K N; Rosauer R; Linthicum D S; Edmundson A B
Intramolecular signaling upon complexation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(1):101-6.
1994: Anchin J M; Mandal C; Culberson C; Subramaniam S; Linthicum D S
Computer-aided molecular modeling of the binding site architecture for eight monoclonal antibodies that bind a high potency guanidinium sweetener.
Journal of molecular graphics 1994;12(4):257-66, 289-90.
1994: Anchin J M; Droupadi P R; DuBois G E; Kellogg M S; Nagarajan S; Carter J S; Linthicum D S
Identification of residues in monoclonal antibody NC10.8 that bind to the sweetener N-(p-cyanophenyl)-N'-(diphenylmethyl)guanidinoacetic acid by using radioligand binding, absorption and fluorescence spectroscopy, computer-aided molecular modeling, and site-directed mutagenesis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3059-69.
1994: Droupadi P R; Varga J M; Linthicum D S
Mechanism of allergenic cross-reactions--IV. Evidence for participation of aromatic residues in the ligand binding site of two multi-specific IgE monoclonal antibodies.
Molecular immunology 1994;31(7):537-48.
1994: Droupadi P R; Meyers E A; Linthicum D S
Spectroscopic evidence for charge-transfer complexation in monoclonal antibodies that bind opiates.
Journal of protein chemistry 1994;13(3):297-306.
1994: Yong T; Bebo B F; Sapatino B V; Welsh C J; Orr E L; Linthicum D S
Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice.
Journal of neurotrauma 1994;11(2):161-71.
1994: Guddat L W; Shan L; Anchin J M; Linthicum D S; Edmundson A B
Local and transmitted conformational changes on complexation of an anti-sweetener Fab.
Journal of molecular biology 1994;236(1):247-74.
1994: Bebo B F; Linthicum D S
Nucleotide sequence of the TNF type I receptor from a mouse endothelioma cell line.
Immunogenetics 1994;39(6):450-1.
1993: Sapatino B V; Welsh C J; Smith C A; Bebo B F; Linthicum D S
Cloned mouse cerebrovascular endothelial cells that maintain their differentiation markers for factor VIII, low density lipoprotein, and angiotensin-converting enzyme.
In vitro cellular & developmental biology. Animal 1993;29A(12):923-8.
1993: Anchin J M; Linthicum D S
Variable region sequence and characterization of monoclonal antibodies to a N,N',N"-trisubstituted guanidine high potency sweetener.
Molecular immunology 1993;30(16):1463-71.
1993: Yong T; Meininger G A; Linthicum D S
Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not BALB/c mice.
Journal of neuroimmunology 1993;45(1-2):47-52.
1993: Bodani U C; Anchin J M; Linthicum D S
Monoclonal antibodies to sweet taste proteins: II. Development of two different immunoassays for thaumatin and monellin.
Hybridoma 1993;12(2):177-83.
1992: Pride M W; Shi H; Anchin J M; Linthicum D S; LoVerde P T; Thakur A; Thanavala Y
Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):11900-4.
1992: Droupadi P R; Anchin J M; Meyers E A; Linthicum D S
Spectrofluorimetric study of the intermolecular complexation of monoclonal antibodies with the high potency sweetener N-(p-cyanophenyl)-N'-(diphenylmethyl) guanidineacetic acid.
Journal of molecular recognition : JMR 1992;5(4):173-9.
1992: Gabler D; Mandal C; Harrington C; Adamczyk M; Linthicum D S
Kinetic and energetic parameters of imipramine binding to monoclonal antibodies as measured by fluorescence spectroscopy.
Hybridoma 1992;11(3):301-10.
1992: Mandal C; Mandal C; Harrington C; Adamczyk M; Linthicum D S
Kinetics of haloperidol binding to monoclonal antibodies as measured by direct fluorescence quenching.
Biochemical pharmacology 1992;43(4):855-63.
1991: Mandal C; Shirley F; Anchin J M; Mandal C; Linthicum D S
Monoclonal antibodies to sweet taste proteins. I. Analysis of antigenic epitopes on thaumatin by competitive inhibition assays.
Hybridoma 1991;10(4):459-66.
1991: Kussie P H; Anchin J M; Subramaniam S; Glasel J A; Linthicum D S
Analysis of the binding site architecture of monoclonal antibodies to morphine by using competitive ligand binding and molecular modeling.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4248-57.
1991: Anchin J M; Subramaniam S; Linthicum D S
Binding of the neuroleptic drug haloperidol to a monoclonal antibody: refinement of the binding site molecular model using canonical structures.
Journal of molecular recognition : JMR 1991;4(1):7-15.
1989: Simmons R D; Buzbee T M; Linthicum D S
Methysergide, a serotonin antagonist, does not inhibit the expression of autoimmune encephalomyelitis in the rabbit.
Journal of neuroimmunology 1989;22(1):77-9.
1989: Kussie P H; Albright G; Linthicum D S
Production and characterization of monoclonal idiotypes and anti-idiotypes for small ligands.
Methods in enzymology 1989;178():49-63.
1989: Kussie P H; Sherman M A; Marchetti D; Linthicum D S
Molecular analysis of monoclonal idiotypes and anti-idiotypes.
Methods in enzymology 1989;178():91-107.
1988: Linthicum D S; Bolger M B; Kussie P H; Albright G M; Linton T A; Combs S; Marchetti D
Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand.
Clinical chemistry 1988;34(9):1676-80.
1988: Simmons R D; Buzbee T M; Linthicum D S
An immunohistological study of autoimmune encephalomyelitis and neuritis in the rabbit. Observations in the dorsal root ganglion using the freeze-dried paraffin-embedded tissue technique.
Journal of the neurological sciences 1988;83(2-3):293-304.
1987: Simmons R D; Buzbee T M; Linthicum D S
A freeze-dried paraffin-embedded tissue technique for immunohistochemical studies requiring unfixed tissue from the nervous system.
Journal of neuroscience methods 1987;22(2):91-6.
1987: Simmons R D; Buzbee T M; Linthicum D S; Mandy W J; Chen G; Wang C
Simultaneous visualization of vascular permeability change and leukocyte egress in the central nervous system during autoimmune encephalomyelitis.
Acta neuropathologica 1987;74(2):191-3.
1986: Sherman M A; Linthicum D S; Bolger M B
Haloperidol binding to monoclonal antibodies: conformational analysis and relationships to D-2 receptor binding.
Molecular pharmacology 1986;29(6):589-98.
1986: Simmons R D; Linthicum D S
A simple 'free 3H-ligand' assay for rapid screening of hybridoma monoclonal antibodies against neurotransmitter analogs and anti-idiotype antibodies.
Journal of neuroimmunology 1986;11(3):245-9.
1985: Bolger M B; Flurkey K; Simmons R D; Linthicum D S; Laduron P; Michiels M
Preparation and characterization of antisera and monoclonal antibodies to haloperidol.
Immunological investigations 1985;14(6):523-40.
1985: Linthicum D S; Bolger M B
Using molecular mimicry to produce anti-receptor antibodies.
BioEssays : news and reviews in molecular, cellular and developmental biology 1985;3(5):213-7.
1985: Flurkey K; Bolger M B; Linthicum D S
Preparation and characterization of antisera and monoclonal antibodies to serotonergic and dopaminergic ligands.
Journal of neuroimmunology 1985;8(2-3):115-27.

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