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Dennis Liotta

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Andrew Brown; Dennis C Liotta; Clinton Maddox; Terry W Moore; Andrew Prussia; Qi Shi; Hyunsuk Shim; Younghyoun Yoon; James P Snyder
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
Terry W Moore; Michael G Natchus; John M Ndungu; Richard K Plemper; Manohar T Saindane; Kasinath Sana; James P Snyder; Dennis C Liotta; Mark A Lockwood; Pahk Thepchatri; Dan Yan; Aiming Sun
Asymmetric synthesis of host-directed inhibitors of myxoviruses.
Rose M Santangelo; Katie L Strong; Stephen F Traynelis; Sommer S Zimmerman; Timothy M Acker; Brooke M Katzman; Dennis C Liotta
Novel NMDA receptor modulators: an update.

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All Publications

2013: Andrew Brown; Dennis C Liotta; Clinton Maddox; Terry W Moore; Andrew Prussia; Qi Shi; Hyunsuk Shim; Younghyoun Yoon; James P Snyder
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
Journal of medicinal chemistry 2013;56(9):3456-66.
2013: Terry W Moore; Michael G Natchus; John M Ndungu; Richard K Plemper; Manohar T Saindane; Kasinath Sana; James P Snyder; Dennis C Liotta; Mark A Lockwood; Pahk Thepchatri; Dan Yan; Aiming Sun
Asymmetric synthesis of host-directed inhibitors of myxoviruses.
Beilstein journal of organic chemistry 2013;9():197-203.
2012: Rose M Santangelo; Katie L Strong; Stephen F Traynelis; Sommer S Zimmerman; Timothy M Acker; Brooke M Katzman; Dennis C Liotta
Novel NMDA receptor modulators: an update.
Expert opinion on therapeutic patents 2012;22(11):1337-52.
2012: Pieter B Burger; Hiro Furukawa; Matthew Geballe; Erkan Karakas; Dennis C Liotta; James P Snyder; Hongjie Yuan; Stephen F Traynelis
Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.
Molecular pharmacology 2012;82(2):344-59.
2012: J Maina Ndungu; Richard K Plemper; G Prabhakar Reddy; Manohar T Saindane; James P Snyder; Richard F Arrendale; Taylor Evers; Randy Howard; Stefanie A Krumm; Dennis C Liotta; Michael G Natchus; Dan Yan; Aiming Sun
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.
Journal of medicinal chemistry 2012;55(9):4220-30.
2012: Grant A Boyle; Christopher D Edlin; Yongfeng Li; Dennis C Liotta; Garreth L Morgans; Chitalu C Musonda
Enantioselective synthesis of the carbocyclic nucleoside (-)-abacavir.
Organic & biomolecular chemistry 2012;10(9):1870-6.
2012: Anlys Olivera; Andrew P Brown; Fang Hu; Dennis C Liotta; Adam I Marcus; Andrew H Miller; Terry W Moore; Hyunsuk Shim; James P Snyder; Aiming Sun; Younghyoun Yoon; Thaddeus W W Pace
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.
International immunopharmacology 2012;12(2):368-77.
2012: Zhongxing Liang; Songbai Lin; Dennis C Liotta; Jin Liu; Mauricio Rojas; Maiko Sasaki; Richard F Arrendale; Mark M Goodman; Hans E Grossniklaus; Jan-Michael A Klapproth; James P Snyder; Ronald J Voll; Jianguo Xu; Hua Yang; Younghyoun Yoon; C Chris Yun; Weiqiang Zhan; Aizhi Zhu; Hyunsuk Shim
Development of a unique small molecule modulator of CXCR4.
PloS one 2012;7(4):e34038.
2011: Weiqiang Zhan; Yi Jiang; Susan Bane; David G I Kingston; Dennis C Liotta; Peggy J Brodie; Shubhada Sharma; James P Snyder
C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(52):14792-804.
2011: Timothy M Acker; Pieter B Burger; Kasper B Hansen; Henrik S Jensen; Dennis C Liotta; Praseeda Mullasseril; Kevin K Ogden; James P Snyder; Katie M Vance; Hongjie Yuan; Stephen F Traynelis
Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.
Molecular pharmacology 2011;80(5):782-95.
2011: Holly Symolon; Anatoliy Bushnev; Qiong Peng; Harsha Ramaraju; Suzanne G Mays; Jeremy C Allegood; Sarah T Pruett; M Cameron Sullards; Dirck L Dillehay; Dennis C Liotta; Alfred H Merrill
Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.
Molecular cancer therapeutics 2011;10(4):648-57.
2011: Natalia Makarova; Chunxia Zhao; Yuanyuan Zhang; Sushma M Bhosle; Suganthi Suppiah; Jeanne M Rhea; Natalia Kozyr; Rebecca S Arnold; Hinh Ly; Ross J Molinaro; Tristam PARSLOW; Eric Hunter; Dennis C Liotta; John Petros; Jerry L Blackwell
Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model.
PloS one 2011;6(4):e18272.
2010: Aizhi Zhu; Weiqiang Zhan; Zhongxing Liang; Younghyoun Yoon; Hua Yang; Hans E Grossniklaus; Jianguo Xu; Mauricio Rojas; Mark Lockwood; James P Snyder; Dennis C Liotta; Hyunsuk Shim
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.
Journal of medicinal chemistry 2010;53(24):8556-68.
2010: Dean A Heathcote; Hetal Patel; Sebastian H B Kroll; Pascale Hazel; Manikandan Periyasamy; Mary Alikian; Seshu K Kanneganti; Ashutosh S Jogalekar; Bodo Scheiper; Marion Barbazanges; Andreas Blum; Jan Brackow; Alekasandra Siwicka; Robert D M Pace; Matthew J Fuchter; James P Snyder; Dennis C Liotta; Paul S Freemont; Eric O Aboagye; R Charles Coombes; Anthony G M Barrett; Simak Ali
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Journal of medicinal chemistry 2010;53(24):8508-22.
2010: Shala L Thomas; Jing Zhao; Zijian Li; Bin Lou; Yuhong Du; Jamie Purcell; James P Snyder; Fadlo R Khuri; Dennis C Liotta; Haian Fu
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy.
Biochemical pharmacology 2010;80(9):1309-16.
2010: Xin Tan; Neil Sidell; Alessandra Mancini; Ruo-Pan Huang; Ira R Horowitz; Dennis C Liotta; Robert N Taylor; Friedrich Wieser
Multiple anticancer activities of EF24, a novel curcumin analog, on human ovarian carcinoma cells.
Reproductive sciences (Thousand Oaks, Calif.) 2010;17(10):931-40.
2010: Cara A Mosley; Timothy M Acker; Kasper B Hansen; Praseeda Mullasseril; Karen T Andersen; Phuong Le; Kimberly M Vellano; Hans Bräuner-Osborne; Dennis C Liotta; Stephen F Traynelis
Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.
Journal of medicinal chemistry 2010;53(15):5476-90.
2010: Sushma M Bhosle; Suganthi Suppiah; Ross Molinaro; Yuying Liang; Rebecca Arnold; William Diehl; Natalia Makarova; Jerry Blackwell; John Petros; Dennis C Liotta; Eric Hunter; Hinh Ly
Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells.
Journal of virology 2010;84(13):6288-96.
2010: Rebecca S Arnold; Natalia V Makarova; Adeboye O Osunkoya; Suganthi Suppiah; Takara A Scott; Nicole A Johnson; Sushma M Bhosle; Dennis C Liotta; Eric Hunter; Fray F Marshall; Hinh Ly; Ross J Molinaro; Jerry L Blackwell; John Petros
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.
Urology 2010;75(4):755-61.
2010: Yongfeng Li; Priti B Soni; Lingfeng Liu; Xiao Zhang; Dennis C Liotta; Stefan Lutz
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
Bioorganic & medicinal chemistry letters 2010;20(3):841-3.
2010: Krishna K Pandey; James P Snyder; Dennis C Liotta; Djamaladdin G Musaev
Computational studies of transition metal selectivity of octapeptide repeat region of prion protein (PrP).
The journal of physical chemistry. B 2010;114(2):1127-35.
2010: Praseeda Mullasseril; Kasper B Hansen; Katie M Vance; Kevin K Ogden; Hongjie Yuan; Natalie L Kurtkaya; Rose Santangelo; Anna G Orr; Phuong Le; Kimberly M Vellano; Dennis C Liotta; Stephen F Traynelis
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
Nature communications 2010;1():90.
2009: Aiming Sun; Yang J Lu; Haipeng Hu; Mamoru Shoji; Dennis C Liotta; James P Snyder
Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.
Bioorganic & medicinal chemistry letters 2009;19(23):6627-31.
2009: Christopher J MacNevin; Fahim Atif; Iqbal Sayeed; Donald G Stein; Dennis C Liotta
Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury.
Journal of medicinal chemistry 2009;52(19):6012-23.
2009: Cara A Mosley; Scott J Myers; Ernest E Murray; Rose Santangelo; Yesim A Tahirovic; Natalie Kurtkaya; Praseeda Mullasseril; Hongjie Yuan; Polina Lyuboslavsky; Phuong Le; Lawrence J Wilson; Manuel Yepes; ray dingledine; Stephen F Traynelis; Dennis C Liotta
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Bioorganic & medicinal chemistry 2009;17(17):6463-80.
2009: Simak Ali; Dean A Heathcote; Sebastian H B Kroll; Ashutosh S Jogalekar; Bodo Scheiper; Hetal Patel; Jan Brackow; Alekasandra Siwicka; Matthew J Fuchter; Manikandan Periyasamy; Robert S Tolhurst; Seshu K Kanneganti; James P Snyder; Dennis C Liotta; Eric O Aboagye; Anthony G M Barrett; R Charles Coombes
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Cancer research 2009;69(15):6208-15.
2009: Lingfeng Liu; Yongfeng Li; Dennis C Liotta; Stefan Lutz
Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting.
Nucleic acids research 2009;37(13):4472-81.
2009: Pahk Thepchatri; Jaeki Min; Thota Ganesh; Yuhong Du; Iestyn Lewis; Serdar Kurtkaya; Andrew Prussia; Lian Li; Blossom Sneed; Richard K Plemper; Haian Fu; Dennis C Liotta; James P Snyder; ray dingledine; Aiming Sun
Cancer and virus leads by HTS, chemical design and SEA data mining.
Current topics in medicinal chemistry 2009;9(13):1159-71.
2009: Cara A Mosley; Lawrence J Wilson; John M Wiseman; Jason W Skudlarek; Dennis C Liotta
Recent patents regarding the discovery of small molecule CXCR4 antagonists.
Expert opinion on therapeutic patents 2009;19(1):23-38.
2008: Yesim A Tahirovic; Matthew Geballe; Ewa Gruszecka-Kowalik; Scott J Myers; Polina Lyuboslavsky; Phuong Le; Adam French; Hasan Irier; Woo-Baeg Choi; Keith Easterling; Hongjie Yuan; Lawrence J Wilson; Robert Kotloski; James O McNamara; ray dingledine; Dennis C Liotta; Stephen F Traynelis; James P Snyder
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.
Journal of medicinal chemistry 2008;51(18):5506-21.
2008: Andrea L Kasinski; Yuhong Du; Shala L Thomas; Jing Zhao; Shi-Yong Sun; Fadlo R Khuri; Cun-Yu Wang; Mamoru Shoji; Aiming Sun; James P Snyder; Dennis C Liotta; Haian Fu
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Molecular pharmacology 2008;74(3):654-61.
2008: Shala L Thomas; Diansheng Zhong; Wei Zhou; Sanna Malik; Dennis C Liotta; James P Snyder; Ernest Hamel; Paraskevi Giannakakou
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.
Cell cycle (Georgetown, Tex.) 2008;7(15):2409-17.
2008: Sarah T Pruett; Anatoliy Bushnev; Kerri Hagedorn; Madhura Adiga; Christopher A Haynes; M Cameron Sullards; Dennis C Liotta; Alfred H Merrill
Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.
Journal of lipid research 2008;49(8):1621-39.
2008: Thota Ganesh; Jaeki Min; Pahk Thepchatri; Yuhong Du; Lian Li; Iestyn Lewis; Larry Wilson; Haian Fu; Gabriela Chiosis; ray dingledine; Dennis C Liotta; James P Snyder; Aiming Sun
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
Bioorganic & medicinal chemistry 2008;16(14):6903-10.
2008: Weiqiang Zhan; Yi Jiang; Peggy J Brodie; David G I Kingston; Dennis C Liotta; James P Snyder
Design and synthesis of C6-C8 bridged epothilone A.
Organic letters 2008;10(8):1565-8.
2008: Mamoru Shoji; Aiming Sun; Walter Kisiel; Yang J Lu; Hyunsuk Shim; Bernard E McCarey; Christopher Nichols; Ernest T Parker; jan pohl; Cara A Mosley; Aaron R Alizadeh; Dennis C Liotta; James P Snyder
Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.
Journal of drug targeting 2008;16(3):185-97.
2008: Christopher J MacNevin; Rhonda L Moore; Dennis C Liotta
Stereoselective synthesis of quaternary center bearing azetines and their beta-amino acid derivatives.
The Journal of organic chemistry 2008;73(4):1264-9.
2007: Weiqiang Zhan; Zhongxing Liang; Aizhi Zhu; Serdar Kurtkaya; Hyunsuk Shim; James P Snyder; Dennis C Liotta
Discovery of small molecule CXCR4 antagonists.
Journal of medicinal chemistry 2007;50(23):5655-64.
2007: Yongfeng Li; Shuli Mao; Michael W Hager; Kimberlynne D Becnel; Ray F Schinazi; Dennis C Liotta
Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents.
Bioorganic & medicinal chemistry letters 2007;17(12):3398-401.
2007: Cara A Mosley; Dennis C Liotta; James P Snyder
Highly active anticancer curcumin analogues.
Advances in experimental medicine and biology 2007;595():77-103.
2006: Aiming Sun; Andrew Prussia; Weiqiang Zhan; Ernest E Murray; Joshua Doyle; Li-Ting Cheng; Jeong-Joong Yoon; Eugene V Radchenko; Vladimir A Palyulin; Richard W Compans; Dennis C Liotta; Richard K Plemper; James P Snyder
Nonpeptide inhibitors of measles virus entry.
Journal of medicinal chemistry 2006;49(17):5080-92.
2006: Aiming Sun; Mamoru Shoji; Yang J Lu; Dennis C Liotta; James P Snyder
Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system.
Journal of medicinal chemistry 2006;49(11):3153-8.
2006: Ann M Dougherty; Frank E McDonald; Dennis C Liotta; Steven J Moody; David C Pallas; Carrie D Pack; Alfred H Merrill
Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups.
Organic letters 2006;8(4):649-52.
2006: Joshua Doyle; Andrew Prussia; Laura K White; Aiming Sun; Dennis C Liotta; James P Snyder; Richard W Compans; Richard K Plemper
Two domains that control prefusion stability and transport competence of the measles virus fusion protein.
Journal of virology 2006;80(3):1524-36.
2005: Richard K Plemper; Joshua Doyle; Aiming Sun; Andrew Prussia; Li-Ting Cheng; Paul A Rota; Dennis C Liotta; James P Snyder; Richard W Compans
Design of a small-molecule entry inhibitor with activity against primary measles virus strains.
Antimicrobial agents and chemotherapy 2005;49(9):3755-61.
2005: John M Wiseman; Frank E McDonald; Dennis C Liotta
1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols.
Organic letters 2005;7(15):3155-7.
2005: Brenda I Hernandez-Santiago; Huachun Chen; Ghazia Asif; Thierry Beltran; Shuli Mao; Selwyn J Hurwitz; Jason Grier; Harold M McClure; Chung (David) K. Chu; Dennis C Liotta; Ray F Schinazi
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(7):2589-97.
2005: Brian K Adams; Jiyang Cai; Jeff Armstrong; Marike Herold; Yang J Lu; Aiming Sun; James P Snyder; Dennis C Liotta; Dean P Jones; Mamoru Shoji
EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.
Anti-cancer drugs 2005;16(3):263-75.
2004: Shuli Mao; Martin Bouygues; Christopher Welch; Mirlinda Biba; Jen Chilenski; Ray F Schinazi; Dennis C Liotta
Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent.
Bioorganic & medicinal chemistry letters 2004;14(19):4991-4.
2004: Brian K Adams; Eva M Ferstl; Matthew C Davis; Marike Herold; Serdar Kurtkaya; Richard F Camalier; Melinda G Hollingshead; Gurmeet Kaur; Edward A Sausville; Frederick R Rickles; James P Snyder; Dennis C Liotta; Mamoru Shoji
Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents.
Bioorganic & medicinal chemistry 2004;12(14):3871-83.
2004: Richard K Plemper; Karl J Erlandson; Ami S Lakdawala; Aiming Sun; Andrew Prussia; Jutatip Boonsombat; Esin Aki-Sener; Ismail Yalcin; Ilkay Yildiz; Ozlem Temiz-Arpaci; Betul Tekiner; Dennis C Liotta; James P Snyder; Richard W Compans
A target site for template-based design of measles virus entry inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5628-33.
2004: George R Painter; Merrick R Almond; Shuli Mao; Dennis C Liotta
Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.
Current topics in medicinal chemistry 2004;4(10):1035-44.
2003: David S Menaldino; Anatoliy Bushnev; Aiming Sun; Dennis C Liotta; Holly Symolon; Kena Desai; Dirck L Dillehay; Qiong Peng; Elaine Wang; Jeremy C Allegood; Sarah Trotman-Pruett; M Cameron Sullards; Alfred H Merrill
Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(5):373-81.
2003: Narendra B Ambhaikar; James P Snyder; Dennis C Liotta
Diastereoselective addition of chlorotitanium enolate of N-acyl thiazolidinethione to O-methyl oximes: a novel, stereoselective synthesis of alpha,beta-disubstituted beta-amino carbonyl compounds via chiral auxiliary mediated azetine formation.
Journal of the American Chemical Society 2003;125(13):3690-1.
2003: Yvan Guindon; William W Ogilvie; Josée Bordeleau; Wei Li Cui; Kathy Durkin; Vida Gorys; Hélène Juteau; René Lemieux; Dennis C Liotta; Bruno Simoneau; Christiane Yoakim
Opening of tartrate acetals using dialkylboron bromide: evidence for stereoselectivity downstream from ring fission.
Journal of the American Chemical Society 2003;125(2):428-36.
2002: Kena Desai; M Cameron Sullards; Jeremy C Allegood; Elaine Wang; Eva M. Schmelz; Michaela Hartl; Hans-Ulrich Humpf; Dennis C Liotta; Qiong Peng; Alfred H Merrill
Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.
Biochimica et biophysica acta 2002;1585(2-3):188-92.
2002: Ami S Lakdawala; David M Morgan; Dennis C Liotta; David G Lynn; James P Snyder
Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates.
Journal of the American Chemical Society 2002;124(51):15150-1.
2002: Ray F Schinazi; John Mellors; Holly Bazmi; Sharon Diamond; Sena Garber; Karen Gallagher; Romas Geleziunas; Ronald Klabe; James Michael Pierce; Marlene Rayner; Jing-Tao Wu; Hangchun Zhang; Jennifer Hammond; Lee Bacheler; Douglas J Manion; Michael J Otto; Lieven Stuyver; George L Trainor; Dennis C Liotta; Susan Erickson-Viitanen
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrobial agents and chemotherapy 2002;46(5):1394-401.
2001: Kyriacos C Nicolaou; Kenji Namoto; Andreas Ritzén; T Ulven; M Shoji; Jian Li; G D'Amico; Dennis C Liotta; Christopher French; Markus Wartmann; Karl-Heinz Altmann; Paraskevi Giannakakou
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.
Journal of the American Chemical Society 2001;123(38):9313-23.
2001: H Venkatesan; M C Davis; Y Altas; James P Snyder; Dennis C Liotta
Total synthesis of SR 121463 A, a highly potent and selective vasopressin v(2) receptor antagonist.
The Journal of organic chemistry 2001;66(11):3653-61.
2001: D A Judd; James Nettles; Neysa Nevins; James P Snyder; Dennis C Liotta; Jordan Tang; J Ermolieff; Ray F Schinazi; Craig L Hill
Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.
Journal of the American Chemical Society 2001;123(5):886-97.
2000: M Wang; Ben Cornett; James Nettles; Dennis C Liotta; James P Snyder
The oxetane ring in taxol.
The Journal of organic chemistry 2000;65(4):1059-68.
2000: Ray F Schinazi; Selwyn J Hurwitz; Irina Liberman; AS Juodawlkis; Phillip Tharnish; J Shi; Dennis C Liotta; J A Coderre; Jeffrey Olson
Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):725-30.
2000: Anatoliy Bushnev; Dennis C Liotta
Practical synthesis of N-palmitoylsphingomyelin and N-palmitoyldihydrosphingomyelin.
Methods in enzymology 2000;311():535-47.
2000: C Curfman; Dennis C Liotta
Synthesis of sphingosine and sphingoid bases.
Methods in enzymology 2000;311():391-440.
1999: lisa Ann warden; David S Menaldino; T Wilson; Dennis C Liotta; Elizabeth Smith; Alfred H Merrill
Identification of ammonium ion and 2,6-bis(omega-aminobutyl)- 3, 5-diiminopiperazine as endogenous factors that account for the "burst" of sphingosine upon changing the medium of J774 cells in culture.
The Journal of biological chemistry 1999;274(48):33875-80.
1999: Eva M. Schmelz; Anatoliy Bushnev; Dirck L Dillehay; M Cameron Sullards; Dennis C Liotta; Alfred H Merrill
Ceramide-beta-D-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis.
Cancer research 1999;59(22):5768-72.
1999: M Wang; X Xia; Y Kim; D Hwang; J M Jansen; M Botta; Dennis C Liotta; James P Snyder
A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone.
Organic letters 1999;1(1):43-6.
1999: J Shi; J J McAtee; S Schlueter Wirtz; Phillip Tharnish; AS Juodawlkis; Dennis C Liotta; Ray F Schinazi
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Journal of medicinal chemistry 1999;42(5):859-67.
1999: L Ma; Selwyn J Hurwitz; J Shi; J J Mcatee; Dennis C Liotta; Harold M McClure; Ray F Schinazi
Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1999;43(2):381-4.
1998: Hans-Ulrich Humpf; Eva M. Schmelz; Filmore I Meredith; H Vesper; T R Vales; Elaine Wang; David S Menaldino; Dennis C Liotta; Alfred H Merrill
Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.
The Journal of biological chemistry 1998;273(30):19060-4.
1998: Diane F Birt; Alfred H Merrill; T Barnett; B Enkvetchakul; Parviz M Pour; Dennis C Liotta; V Geisler; David S Menaldino; J Schwartzbauer
Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine.
Nutrition and cancer 1998;31(2):119-26.
1997: Mariana Nikolova-Karakashian; Edward T Morgan; C Alexander; Dennis C Liotta; Alfred H Merrill
Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.
The Journal of biological chemistry 1997;272(30):18718-24.
1997: Eva M. Schmelz; Anatoliy Bushnev; Dirck L Dillehay; Dennis C Liotta; Alfred H Merrill
Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones.
Nutrition and cancer 1997;28(1):81-5.
1996: Alfred H Merrill; Dennis C Liotta; Ronald T Riley
Fumonisins: fungal toxins that shed light on sphingolipid function.
Trends in cell biology 1996;6(6):218-23.
1996: Alfred H Merrill; Elaine Wang; T R Vales; Elizabeth Smith; J J Schroeder; David S Menaldino; C Alexander; H M Crane; J Xia; Dennis C Liotta; Filmore I Meredith; Ronald T Riley
Fumonisin toxicity and sphingolipid biosynthesis.
Advances in experimental medicine and biology 1996;392():297-306.
1995: H Xie; M Voronkov; Dennis C Liotta; B A Korba; Ray F Schinazi; Douglas D Richman; Karl Y Hostetler
Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
Antiviral research 1995;28(2):113-20.
1995: M Pushkareva; R Chao; Alicja Bielawska; Alfred H Merrill; H M Crane; B Lagu; Dennis C Liotta; Yusuf A Hannun
Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine.
Biochemistry 1995;34(6):1885-92.
1994: V R Jarugula; Ray F Schinazi; G Fulcrand; Y el Kattan; Dennis C Liotta; F Douglas Boudinot
Pharmacokinetics of 5-carboranyl-2'-deoxyuridine in rats.
Journal of pharmaceutical sciences 1994;83(12):1697-9.
1994: Ray F Schinazi; Gilles Gosselin; Abdesslem Faraj; B E Korba; Dennis C Liotta; Chung (David) K. Chu; Christophe Mathé; Jean-Louis Imbach; Jean-Pierre Sommadossi
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
Antimicrobial agents and chemotherapy 1994;38(9):2172-4.
1994: Ray F Schinazi; N M Goudgaon; G Fulcrand; Y el Kattan; Z Lesnikowski; G Ullas; J Moravek; Dennis C Liotta
Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine.
International journal of radiation oncology, biology, physics 1994;28(5):1113-20.
1994: J J Schroeder; H M Crane; J Xia; Dennis C Liotta; Alfred H Merrill
Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.
The Journal of biological chemistry 1994;269(5):3475-81.
1994: C V Abobo; L Ni; Ray F Schinazi; Dennis C Liotta; F Douglas Boudinot
Pharmacokinetics of 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats.
Journal of pharmaceutical sciences 1994;83(1):96-9.
1993: Alicja Bielawska; H M Crane; Dennis C Liotta; Lina M Obeid; Yusuf A Hannun
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.
The Journal of biological chemistry 1993;268(35):26226-32.
1993: L W Frick; L St John; L C Taylor; G R Painter; P A Furman; Dennis C Liotta; E S Furfine; D J Nelson
Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus.
Antimicrobial agents and chemotherapy 1993;37(11):2285-92.
1993: Dominique Mathez; Ray F Schinazi; Dennis C Liotta; Jacques Leibowitch
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro.
Antimicrobial agents and chemotherapy 1993;37(10):2206-11.
1993: Alicja Bielawska; D Menaldiv; Dennis C Liotta; Yusuf A Hannun
Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids.
The Biochemical journal 1993;294 ( Pt 3)():699-703.
1993: J E Wilson; J L Martin; K Borroto-Esoda; S Hopkins; G Painter; Dennis C Liotta; P A Furman
The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.
Antimicrobial agents and chemotherapy 1993;37(8):1720-2.
1993: Donna S Shewach; Dennis C Liotta; Ray F Schinazi
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase.
Biochemical pharmacology 1993;45(7):1540-3.
1993: Ray F Schinazi; R M Lloyd; M H Nguyen; D L Cannon; A McMillan; N Ilksoy; Chung (David) K. Chu; Dennis C Liotta; H Z Bazmi; J W Mellors
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
Antimicrobial agents and chemotherapy 1993;37(4):875-81.
1992: P A Furman; M Davis; Dennis C Liotta; M Paff; L W Frick; D J Nelson; R E Dornsife; J A Wurster; L J Wilson; J A Fyfe
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Antimicrobial agents and chemotherapy 1992;36(12):2686-92.
1992: Ray F Schinazi; F Douglas Boudinot; S S Ibrahim; C Manning; H M McClure; Dennis C Liotta
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1992;36(11):2432-8.
1992: C N Chang; S L Doong; J H Zhou; J Warren Beach; Lak Shin Jeong; Chung (David) K. Chu; C H Tsai; Yung-Chi Cheng; Dennis C Liotta; Ray F Schinazi
Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
The Journal of biological chemistry 1992;267(20):13938-42.
1992: B Enkvetchakul; T Barnett; Dennis C Liotta; V Geisler; David S Menaldino; Alfred H Merrill; Diane F Birt
Influences of sphingosine on two-stage skin tumorigenesis in Sencar mice.
Cancer letters 1992;62(1):35-42.
1991: S L Doong; C H Tsai; Ray F Schinazi; Dennis C Liotta; Yung-Chi Cheng
Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8495-9.
1991: Tzipora Goldkorn; K A Dressler; J Muindi; N S Radin; J Mendelsohn; D Menaldino; Dennis C Liotta; Richard Kolesnick
Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action.
The Journal of biological chemistry 1991;266(24):16092-7.
1990: P Greenberg; Alfred H Merrill; Dennis C Liotta; G A Grabowski
Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site.
Biochimica et biophysica acta 1990;1039(1):12-20.
1990: Victoria L Stevens; S Nimkar; W C Jamison; Dennis C Liotta; Alfred H Merrill
Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C.
Biochimica et biophysica acta 1990;1051(1):37-45.
1989: C W Slife; Elaine Wang; R Hunter; S Wang; C Burgess; Dennis C Liotta; Alfred H Merrill
Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum.
The Journal of biological chemistry 1989;264(18):10371-7.
1989: J M Rodriguez-Paris; M Shoji; S Yeola; Dennis C Liotta; W R Vogler; J F Kuo
Fluorimetric studies of protein kinase C interactions with phospholipids.
Biochemical and biophysical research communications 1989;159(2):495-500.
1988: E Wilson; Elaine Wang; R E Mullins; D J Uhlinger; Dennis C Liotta; David J. Lambeth; Alfred H Merrill
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
The Journal of biological chemistry 1988;263(19):9304-9.
1988: Alfred H Merrill; Elaine Wang; R E Mullins; W C Jamison; S Nimkar; Dennis C Liotta
Quantitation of free sphingosine in liver by high-performance liquid chromatography.
Analytical biochemistry 1988;171(2):373-81.