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Stan Lipkowitz

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Chemicals & Drugs

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Stephen C Kales; Philip E Ryan; Stan Lipkowitz
Cbl exposes its RING finger.
Philip E Ryan; Rajgopal Yadavalli; Han Zhang; Stephen C Kales; Marion M Nau; Stan Lipkowitz
Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.
Sireesha V Garimella; Andrea Rocca; Stan Lipkowitz
WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.

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All Publications

2012: Stephen C Kales; Philip E Ryan; Stan Lipkowitz
Cbl exposes its RING finger.
Nature structural & molecular biology 2012;19(2):131-3.
2012: Philip E Ryan; Rajgopal Yadavalli; Han Zhang; Stephen C Kales; Marion M Nau; Stan Lipkowitz
Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.
PloS one 2012;7(11):e49428.
2012: Sireesha V Garimella; Andrea Rocca; Stan Lipkowitz
WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.
Molecular cancer research : MCR 2012;10(1):75-85.
2011: Hye-Young Yoon; Stephen C Kales; RuiBai Luo; Stan Lipkowitz; Paul A Randazzo
ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.
Biology of the cell / under the auspices of the European Cell Biology Organization 2011;103(4):171-84.
2010: Philip E Ryan; Nina Sivadasan-Nair; Marion M Nau; Sarah Nicholas; Stan Lipkowitz
The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.
The Journal of biological chemistry 2010;285(31):23687-98.
2010: Lyndsay M Murrow; Sireesha V Garimella; Tamara L Jones; Natasha J Caplen; Stan Lipkowitz
Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome.
Breast cancer research and treatment 2010;122(2):347-57.
2010: Stephen C Kales; Philip E Ryan; Marion M Nau; Stan Lipkowitz
Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.
Cancer research 2010;70(12):4789-94.
2010: Kathryn J Chavez; Sireesha V Garimella; Stan Lipkowitz
Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.
Breast disease 2010;32(1-2):35-48.
2009: Monzur Rahman; Sean R Davis; Janet G Pumphrey; Jing Bao; Marion M Nau; Paul S Meltzer; Stan Lipkowitz
TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.
Breast cancer research and treatment 2009;113(2):217-30.
2007: Stan Lipkowitz; Phillip A Dennis
PPARgamma agonists follow an unknown TRAIL in lung cancer.
Cancer biology & therapy 2007;6(1):107-9.
2007: Anil Sadarangani; Sumie Kato; Natalia Espinoza; Soledad Lange; Carmen Llados; Marisol Espinosa; Manuel Villalón; Stan Lipkowitz; Mauricio Cuello; Gareth Owen
TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract.
Apoptosis : an international journal on programmed cell death 2007;12(1):73-85.
2006: Gareth C Davies; Philip E Ryan; Lambratu Rahman; Maria Zajac-Kaye; Stan Lipkowitz
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.
Oncogene 2006;25(49):6497-509.
2006: Philip E Ryan; Gareth C Davies; Marion M Nau; Stan Lipkowitz
Regulating the regulator: negative regulation of Cbl ubiquitin ligases.
Trends in biochemical sciences 2006;31(2):79-88.
2006: Nicholas W Choong; Sascha Dietrich; Tanguy Seiwert; Maria Tretiakova; Vidya Nallasura; Gareth C Davies; Stan Lipkowitz; Aliya N Husain; Ravi Salgia; Patrick C Ma
Gefitinib response of erlotinib-refractory lung cancer involving meninges--role of EGFR mutation.
Nature clinical practice. Oncology 2006;3(1):50-7; quiz 1 p following 57.
2005: Kathleen A Calzone; Sheila A Prindiville; Oxana Jourkiv; Jean Jenkins; Maria DeCarvalho; Dawn B Wallerstedt; David J Liewehr; Seth M Steinberg; Peter Soballe; Stan Lipkowitz; Pamela Klein; Ilan R Kirsch
Randomized comparison of group versus individual genetic education and counseling for familial breast and/or ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(15):3455-64.
2004: Gareth C Davies; Seth A Ettenberg; Ashley O Coats; Mark Mussante; Sarangan Ravichandran; Jack Collins; Marion M Nau; Stan Lipkowitz
Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.
Oncogene 2004;23(42):7104-15.
2004: Antoinette R Tan; Xiaowei Yang; Stephen M Hewitt; Arlene Berman; Erin R Lepper; Alex Sparreboom; Allyson L Parr; William D Figg; Catherine Chow; Seth M Steinberg; Stephen L Bacharach; Millie Whatley; Jorge Carrasquillo; Jaime Brahim; Seth A Ettenberg; Stan Lipkowitz; Sandra M Swain
Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(15):3080-90.
2004: Mauricio Cuello; A O Coats; I Darko; Seth A Ettenberg; Ginger J Gardner; Marion M Nau; J Rebecca Liu; Michael J Birrer; Stan Lipkowitz
N-(4-hydroxyphenyl) retinamide (4HPR) enhances TRAIL-mediated apoptosis through enhancement of a mitochondrial-dependent amplification loop in ovarian cancer cell lines.
Cell death and differentiation 2004;11(5):527-41.
2004: Lambratu Rahman; Donna Voeller; Monzur Rahman; Stan Lipkowitz; Carmen J Allegra; J Carl Barrett; Frederic J Kaye; Maria Zajac-Kaye
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.
Cancer cell 2004;5(4):341-51.
2003: Emily K Griffiths; Otto H Sanchez; Pleasantine Mill; Connie M Krawczyk; Carlo V Hojilla; Evelyn Rubin; Marion M Nau; Rama Khokha; Stan Lipkowitz; Chi-Chung Hui; Josef M Penninger
Cbl-3-deficient mice exhibit normal epithelial development.
Molecular and cellular biology 2003;23(21):7708-18.
2003: Alessandra Magnifico; Seth A Ettenberg; Cuihong Yang; Jennifer Mariano; Swati Tiwari; Shengyun Fang; Stan Lipkowitz; Allan M Weissman
WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation.
The Journal of biological chemistry 2003;278(44):43169-77.
2003: Marion M Nau; Stan Lipkowitz
Comparative genomic organization of the cbl genes.
Gene 2003;308():103-13.
2003: Stan Lipkowitz
The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer.
Breast cancer research : BCR 2003;5(1):8-15.
2002: Mauricio Cuello; Marion Nau; Stan Lipkowitz
Apoptosis and the treatment of breast cancer.
Breast disease 2002;15():71-82.
2001: Pamela Klein; E Glaser; Liam Grogan; M Keane; Stan Lipkowitz; Peter Soballe; L Brooks; Jean Jenkins; Seth M Steinberg; D M DeMarini; Ilan Kirsch
Biomarker assays in nipple aspirate fluid.
The breast journal 2001;7(6):378-87.
2001: Seth A Ettenberg; A Magnifico; Mauricio Cuello; Marion M Nau; Yaffa R Rubinstein; Yosef Yarden; Allan M Weissman; Stan Lipkowitz
Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.
The Journal of biological chemistry 2001;276(29):27677-84.
2001: Mauricio Cuello; Seth A Ettenberg; Amy S Clark; MM Keane; R H Posner; Marion M Nau; Phillip A Dennis; Stan Lipkowitz
Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.
Cancer research 2001;61(12):4892-900.
2001: Mauricio Cuello; Seth A Ettenberg; Marion M Nau; Stan Lipkowitz
Synergistic induction of apoptosis by the combination of trail and chemotherapy in chemoresistant ovarian cancer cells.
Gynecologic oncology 2001;81(3):380-90.
2000: MM Keane; Yaffa R Rubinstein; Mauricio Cuello; Seth A Ettenberg; P Banerjee; Marion M Nau; Stan Lipkowitz
Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines.
Breast cancer research and treatment 2000;64(2):211-9.
2000: Yong Lin; Anne Devin; A Cook; MM Keane; Michelle A Kelliher; Stan Lipkowitz; Zheng-gang Liu
The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.
Molecular and cellular biology 2000;20(18):6638-45.
2000: Kurt Bachmaier; Connie M Krawczyk; Ivona Kozieradzki; Young-Yun Kong; Takehiko Sasaki; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; Andrew Wakeham; Annick Itie; J Le; Pamela S Ohashi; Ildiko Sarosi; Hiroshi Nishina; Stan Lipkowitz; Josef M Penninger
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Nature 2000;403(6766):211-6.
1999: Gil Levkowitz; Hadassa Waterman; Seth A Ettenberg; Menachem Katz; Alexander Y Tsygankov; Iris Alroy; Sara Lavi; K Iwai; Yuval Reiss; Aaron Ciechanover; Stan Lipkowitz; Yosef Yarden
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
Molecular cell 1999;4(6):1029-40.
1999: Seth A Ettenberg; Yaffa R Rubinstein; P Banerjee; Marion M Nau; MM Keane; Stan Lipkowitz
cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors.
Molecular cell biology research communications : MCBRC 1999;2(2):111-8.
1999: MM Keane; Seth A Ettenberg; Marion M Nau; P Banerjee; Mauricio Cuello; Josef M Penninger; Stan Lipkowitz
cbl-3: a new mammalian cbl family protein.
Oncogene 1999;18(22):3365-75.
1999: WD Chen; Joseph Geradts; MM Keane; Stan Lipkowitz; Maria Zajac-Kaye; Frederic J Kaye
The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells.
Molecular cell biology research communications : MCBRC 1999;1(3):216-20.
1999: Seth A Ettenberg; MM Keane; Marion M Nau; M Frankel; Ling Mei Wang; JH Pierce; Stan Lipkowitz
cbl-b inhibits epidermal growth factor receptor signaling.
Oncogene 1999;18(10):1855-66.
1999: MM Keane; Seth A Ettenberg; Marion M Nau; EK Russell; Stan Lipkowitz
Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.
Cancer research 1999;59(3):734-41.
1997: WD Chen; GA Otterson; Stan Lipkowitz; Samir N Khleif; Angela Coxon; Frederic J Kaye
Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding.
Oncogene 1997;14(10):1243-8.
1996: MM Keane; Seth A Ettenberg; G A Lowrey; E K Russell; Stan Lipkowitz
Fas expression and function in normal and malignant breast cell lines.
Cancer research 1996;56(20):4791-8.
1996: MM Keane; G A Lowrey; Seth A Ettenberg; M A Dayton; Stan Lipkowitz
The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells.
Cancer research 1996;56(18):4236-43.
1995: MM Keane; O M Rivero-Lezcano; J A Mitchell; K C Robbins; Stan Lipkowitz
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.
Oncogene 1995;10(12):2367-77.
1994: Ilan R Kirsch; J M Abdallah; VL Bertness; Martha Hale; Stan Lipkowitz; F Lista; D P Lombardi
Lymphocyte-specific genetic instability and cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():287-95.
1993: M Varterasian; Stan Lipkowitz; I Karsch-Mizrachi; B Paterson; I Kirsch
Two new Drosophila genes related to human hematopoietic and neurogenic transcription factors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(11):885-9.
1992: Stan Lipkowitz; V Göbel; M L Varterasian; K Nakahara; K Tchorz; Ilan R Kirsch
A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system.
The Journal of biological chemistry 1992;267(29):21065-71.
1992: Ilan R Kirsch; Stan Lipkowitz
A measure of genomic instability and its relevance to lymphomagenesis.
Cancer research 1992;52(19 Suppl):5545s-5546s.
1992: Stan Lipkowitz; V F Garry; Ilan R Kirsch
Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5301-5.
1992: V Göbel; Stan Lipkowitz; C A Kozak; Ilan R Kirsch
NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(3):143-8.
1992: C Glenn Begley; Stan Lipkowitz; V Göbel; Kathleen A Mahon; VL Bertness; Anthony R Green; N M Gough; Ilan R Kirsch
Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):38-42.
1992: N M Gough; Stan Lipkowitz; Ilan R Kirsch; C Glenn Begley
Localization of murine HLH gene NSCL to chromosome 1 by use of recombinant inbred strains.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(3):182-3.
1990: Stan Lipkowitz; Marc-Henri Stern; Ilan R Kirsch
Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes.
The Journal of experimental medicine 1990;172(2):409-18.
1989: Marc-Henri Stern; Stan Lipkowitz; A Aurias; C Griscelli; G Thomas; Ilan R Kirsch
Inversion of chromosome 7 in ataxia telangiectasia is generated by a rearrangement between T-cell receptor beta and T-cell receptor gamma genes.
Blood 1989;74(6):2076-80.