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Stephen Lippard

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Procedures

X-Ray Crystallography

Living Beings

Methylococcus capsulatus

Genes & Molecular Sequences

Molecular Structure

Phenomena

Anatomy

Hela Cells

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Co-Publications
Name
14
Friesner, Richard
13
Nolan, Elizabeth
12
Spingler, Bernhard
12
Essigmann, John
11
Sazinsky, Matthew
10
Lee, Dongwhan
9
Baik, Mu-Hyun
9
Lim, Mi Hee
8
Jaworski, Jacek
7
Burdette, Shawn
7
Sheng, Morgan
7
Whittington, Douglas
6
Zamble, Deborah
6
Cohen, Seth
6
Gherman, Benjamin

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Publications

TOP 3
Do Loi H; Lippard Stephen J
2-Phenoxypyridyl dinucleating ligands for assembly of diiron(II) complexes: efficient reactivity with O(2) to form (mu-Oxo)diiron(III) units.
Ang Wee Han; Lippard Stephen J
Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site.
Dhar Shanta; Daniel Weston L; Giljohann David A; Mirkin Chad A; Lippard Stephen J
Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.

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All Publications

2009: Do Loi H; Lippard Stephen J
2-Phenoxypyridyl dinucleating ligands for assembly of diiron(II) complexes: efficient reactivity with O(2) to form (mu-Oxo)diiron(III) units.
Inorganic chemistry 2009;48(22):10708-19.
2009: Ang Wee Han; Lippard Stephen J
Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site.
Chemical communications (Cambridge, England) 2009;(39):5820-2.
2009: Dhar Shanta; Daniel Weston L; Giljohann David A; Mirkin Chad A; Lippard Stephen J
Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.
Journal of the American Chemical Society 2009;131(41):14652-3.
2009: Friedle Simone; Kodanko Jeremy J; Morys Anna J; Hayashi Takahiro; Moënne-Loccoz Pierre; Lippard Stephen J
Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization, and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV.
Journal of the American Chemical Society 2009;131(40):14508-20.
2009: Wong Brian A; Friedle Simone; Lippard Stephen J
Subtle modification of 2,2-dipicolylamine lowers the affinity and improves the turn-on of Zn(II)-selective fluorescent sensors.
Inorganic chemistry 2009;48(15):7009-11.
2009: Tonzetich Zachary J; Do Loi H; Lippard Stephen J
Dinitrosyl iron complexes relevant to Rieske cluster nitrosylation.
Journal of the American Chemical Society 2009;131(23):7964-5.
2009: Zhu Guangyu; Lippard Stephen J
Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links.
Biochemistry 2009;48(22):4916-25.
2009: Wong Brian A; Friedle Simone; Lippard Stephen J
Solution and fluorescence properties of symmetric dipicolylamine-containing dichlorofluorescein-based Zn2+ sensors.
Journal of the American Chemical Society 2009;131(20):7142-52.
2009: Song Woon Ju; Behan Rachel K; Naik Sunil G; Huynh Boi Hanh; Lippard Stephen J
Characterization of a peroxodiiron(III) intermediate in the T201S variant of toluene/o-xylene monooxygenase hydroxylase from Pseudomonas sp. OX1.
Journal of the American Chemical Society 2009;131(17):6074-5.
2009: Ang Wee Han; Brown William Wesley; Lippard Stephen J
Preparation of Mammalian Expression Vectors Incorporating Site-Specifically Platinated-DNA Lesions.
Bioconjugate chemistry 2009;20(5):1058-63.
2009: Guggenheim Evan R; Xu Dong; Zhang Christiana X; Chang Pamela V; Lippard Stephen J
Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA.
Chembiochem : a European journal of chemical biology 2009;10(1):141-57.
2009: Nolan Elizabeth M; Lippard Stephen J
Small-molecule fluorescent sensors for investigating zinc metalloneurochemistry.
Accounts of chemical research 2009;42(1):193-203.
2008: Guggenheim Evan R; Ondrus Alison E; Movassaghi Mohammad; Lippard Stephen J
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA.
Bioorganic & medicinal chemistry 2008;16(23):10121-8.
2008: Dhar Shanta; Gu Frank X; Langer Robert; Farokhzad Omid C; Lippard Stephen J
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17356-61.
2008: Zhang Xiao-an; Hayes Dugan; Smith Sarah J; Friedle Simone; Lippard Stephen J
New strategy for quantifying biological zinc by a modified zinpyr fluorescence sensor.
Journal of the American Chemical Society 2008;130(47):15788-9.
2008: Tomat Elisa; Nolan Elizabeth M; Jaworski Jacek; Lippard Stephen J
Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells.
Journal of the American Chemical Society 2008;130(47):15776-7.
2008: Harrop Todd C; Tonzetich Zachary J; Reisner Erwin; Lippard Stephen J
Reactions of synthetic [2Fe-2S] and [4Fe-4S] clusters with nitric oxide and nitrosothiols.
Journal of the American Chemical Society 2008;130(46):15602-10.
2008: Tennyson Andrew G; Dhar Shanta; Lippard Stephen J
Synthesis and characterization of {Ni(NO)}10 and {Co(NO)2}10 complexes supported by thiolate ligands.
Journal of the American Chemical Society 2008;130(45):15087-98.
2008: Nolan Elizabeth M; Lippard Stephen J
Tools and tactics for the optical detection of mercuric ion.
Chemical reviews 2008;108(9):3443-80.
2008: Dhar Shanta; Liu Zhuang; Thomale Jürgen; Dai Hongjie; Lippard Stephen J
Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device.
Journal of the American Chemical Society 2008;130(34):11467-76.
2008: Lovejoy Katherine S; Todd Ryan C; Zhang Shuzhong; McCormick Michael S; D'Aquino J Alejandro; Reardon Joyce T; Sancar Aziz; Giacomini Kathleen M; Lippard Stephen J
cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):8902-7.
2008: Gusarov Ivan; Starodubtseva Marina; Wang Zhi-Qiang; McQuade Lindsey; Lippard Stephen J; Stuehr Dennis J; Nudler Evgeny
Bacterial nitric-oxide synthases operate without a dedicated redox partner.
The Journal of biological chemistry 2008;283(19):13140-7.
2008: Zhao Min; Helms Brett; Slonkina Elena; Friedle Simone; Lee Dongwhan; Dubois Jennifer; Hedman Britt; Hodgson Keith O; Fréchet Jean M J; Lippard Stephen J
Iron complexes of dendrimer-appended carboxylates for activating dioxygen and oxidizing hydrocarbons.
Journal of the American Chemical Society 2008;130(13):4352-63.
2008: Ober Matthias; Lippard Stephen J
A 1,2-d(GpG) cisplatin intrastrand cross-link influences the rotational and translational setting of DNA in nucleosomes.
Journal of the American Chemical Society 2008;130(9):2851-61.
2008: Shatalin Konstantin; Gusarov Ivan; Avetissova Ekaterina; Shatalina Yelena; McQuade Lindsey E; Lippard Stephen J; Nudler Evgeny
Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):1009-13.
2008: Zhang Xiao-an; Song Datong; Lippard Stephen J
A reversible pH-dependent intramolecular pyridine-aldehyde cyclization.
The Journal of organic chemistry 2008;73(2):734-7.
2008: Mukhopadhyay Sumitra; Barnés Carmen M; Haskel Ariel; Short Sarah M; Barnes Katie R; Lippard Stephen J
Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.
Bioconjugate chemistry 2008;19(1):39-49.
2007: Murray Leslie J; García-Serres Ricardo; McCormick Michael S; Davydov Roman; Naik Sunil G; Kim Sun-Hee; Hoffman Brian M; Huynh Boi Hanh; Lippard Stephen J
Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase.
Biochemistry 2007;46(51):14795-809.
2007: Reisner Erwin; Telser Joshua; Lippard Stephen J
A planar carboxylate-rich tetraironII complex and its conversion to linear triironII and paddlewheel diironII complexes.
Inorganic chemistry 2007;46(25):10754-70.
2007: Reisner Erwin; Abikoff Tanya C; Lippard Stephen J
Influence of steric hindrance on the core geometry and sulfoxidation chemistry of carboxylate-rich diiron(II) complexes.
Inorganic chemistry 2007;46(24):10229-40.
2007: Murray Leslie J; Naik Sunil G; Ortillo Danilo O; García-Serres Ricardo; Lee Jessica K; Huynh Boi Hanh; Lippard Stephen J
Characterization of the arene-oxidizing intermediate in ToMOH as a diiron(III) species.
Journal of the American Chemical Society 2007;129(46):14500-10.
2007: Harrop Todd C; Song Datong; Lippard Stephen J
Reactivity pathways for nitric oxide and nitrosonium with iron complexes in biologically relevant sulfur coordination spheres.
Journal of inorganic biochemistry 2007;101(11-12):1730-8.
2007: Conradie Jeanet; Quarless Duncan A; Hsu Hua-Fen; Harrop Todd C; Lippard Stephen J; Koch Stephen A; Ghosh Abhik
Electronic structure and FeNO conformation of nonheme iron-thiolate-NO complexes: an experimental and DFT study.
Journal of the American Chemical Society 2007;129(34):10446-56.
2007: Kim YooJin; Feng Xudong; Lippard Stephen J
Synthesis, structure, and properties of a mixed-valent triiron complex of tetramethyl reductic acid, an ascorbic acid analogue, and its relationship to a functional non-heme iron oxidation catalyst system.
Inorganic chemistry 2007;46(15):6099-107.
2007: Feazell Rodney P; Nakayama-Ratchford Nozomi; Dai Hongjie; Lippard Stephen J
Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design.
Journal of the American Chemical Society 2007;129(27):8438-9.
2007: Murray Leslie J; Lippard Stephen J
Substrate trafficking and dioxygen activation in bacterial multicomponent monooxygenases.
Accounts of chemical research 2007;40(7):466-74.
2007: Zhang Xiao-An; Lovejoy Katherine S; Jasanoff Alan; Lippard Stephen J
Water-soluble porphyrins as a dual-function molecular imaging platform for MRI and fluorescence zinc sensing.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10780-5.
2007: Todd Ryan C; Lovejoy Katherine S; Lippard Stephen J
Understanding the effect of carbonate ion on cisplatin binding to DNA.
Journal of the American Chemical Society 2007;129(20):6370-1.
2007: Jung Yongwon; Lippard Stephen J
Direct cellular responses to platinum-induced DNA damage.
Chemical reviews 2007;107(5):1387-407.
2007: Ober Matthias; Lippard Stephen J
Cisplatin damage overrides the predefined rotational setting of positioned nucleosomes.
Journal of the American Chemical Society 2007;129(19):6278-86.
2007: Nolan Elizabeth M; Lippard Stephen J
Turn-on and ratiometric mercury sensing in water with a red-emitting probe.
Journal of the American Chemical Society 2007;129(18):5910-8.
2007: Lippard Stephen J
Obituary: Frank Albert Cotton (1930-2007).
Nature 2007;446(7136):626.
2007: Mantri Yogita; Lippard Stephen J; Baik Mu-Hyun
Bifunctional binding of cisplatin to DNA: why does cisplatin form 1,2-intrastrand cross-links with ag but not with GA?
Journal of the American Chemical Society 2007;129(16):5023-30.
2007: Rinaldo David; Philipp Dean M; Lippard Stephen J; Friesner Richard A
Intermediates in dioxygen activation by methane monooxygenase: a QM/MM study.
Journal of the American Chemical Society 2007;129(11):3135-47.
2007: Newcomb Martin; Lansakara-P Dharmika S P; Kim Hye-Yeong; Chandrasena R Esala P; Lippard Stephen J; Beauvais Laurance G; Murray Leslie J; Izzo Viviana; Hollenberg Paul F; Coon Minor J
Products from enzyme-catalyzed oxidations of norcarenes.
The Journal of organic chemistry 2007;72(4):1128-33.
2007: Newcomb Martin; Chandrasena R Esala P; Lansakara-P Dharmika S P; Kim Hye-Yeong; Lippard Stephen J; Beauvais Laurance G; Murray Leslie J; Izzo Viviana; Hollenberg Paul F; Coon Minor J
Desaturase reactions complicate the use of norcarane as a mechanistic probe. Unraveling the mixture of twenty-plus products formed in enzyme-catalyzed oxidations of norcarane.
The Journal of organic chemistry 2007;72(4):1121-7.
2007: Lim Mi Hee; Lippard Stephen J
Metal-based turn-on fluorescent probes for sensing nitric oxide.
Accounts of chemical research 2007;40(1):41-51.
2006: Sazinsky Matthew H; Dunten Pete W; McCormick Michael S; DiDonato Alberto; Lippard Stephen J
X-ray structure of a hydroxylase-regulatory protein complex from a hydrocarbon-oxidizing multicomponent monooxygenase, Pseudomonas sp. OX1 phenol hydroxylase.
Biochemistry 2006;45(51):15392-404.
2006: Nolan Elizabeth M; Ryu Jubin W; Jaworski Jacek; Feazell Rodney P; Sheng Morgan; Lippard Stephen J
Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization.
Journal of the American Chemical Society 2006;128(48):15517-28.
2006: McCormick Michael S; Sazinsky Matthew H; Condon Karen L; Lippard Stephen J
X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
Journal of the American Chemical Society 2006;128(47):15108-10.
2006: Nolan Elizabeth M; Jaworski Jacek; Racine Maryann E; Sheng Morgan; Lippard Stephen J
Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: syntheses, characterization, and biological imaging applications.
Inorganic chemistry 2006;45(24):9748-57.
2006: Smith Rhett C; Tennyson Andrew G; Won Annie C; Lippard Stephen J
Conjugated metallopolymers for fluorescent turn-on detection of nitric oxide.
Inorganic chemistry 2006;45(23):9367-73.
2006: Lim Mi Hee; Wong Brian A; Pitcock William H; Mokshagundam Deepa; Baik Mu-Hyun; Lippard Stephen J
Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes.
Journal of the American Chemical Society 2006;128(44):14364-73.
2006: Do Loi; Smith Rhett C; Tennyson Andrew G; Lippard Stephen J
Luminescent properties of water-soluble conjugated metallopolymers and their application to fluorescent nitric oxide detection.
Inorganic chemistry 2006;45(22):8998-9005.
2006: Lim Mi Hee; Lippard Stephen J
Fluorescent nitric oxide detection by copper complexes bearing anthracenyl and dansyl fluorophore ligands.
Inorganic chemistry 2006;45(22):8980-9.
2006: Lieberman Raquel L; Kondapalli Kalyan C; Shrestha Deepak B; Hakemian Amanda S; Smith Stephen M; Telser Joshua; Kuzelka Jane; Gupta Rajeev; Borovik A S; Lippard Stephen J; Hoffman Brian M; Rosenzweig Amy C; Stemmler Timothy L
Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy.
Inorganic chemistry 2006;45(20):8372-81.
2006: Lippard Stephen J
The inorganic side of chemical biology.
Nature chemical biology 2006;2(10):504-7.
2006: Lim Mi Hee; Kuang Chaoyuan; Lippard Stephen J
Nitric oxide-induced fluorescence enhancement by displacement of dansylated ligands from cobalt.
Chembiochem : a European journal of chemical biology 2006;7(10):1571-6.
2006: Zhang Shuzhong; Lovejoy Katherine S; Shima James E; Lagpacan Leah L; Shu Yan; Lapuk Anna; Chen Ying; Komori Takafumi; Gray Joe W; Chen Xin; Lippard Stephen J; Giacomini Kathleen M
Organic cation transporters are determinants of oxaliplatin cytotoxicity.
Cancer research 2006;66(17):8847-57.
2006: Sazinsky Matthew H; Lippard Stephen J
Correlating structure with function in bacterial multicomponent monooxygenases and related diiron proteins.
Accounts of chemical research 2006;39(8):558-66.
2006: Goldsmith Christian R; Lippard Stephen J
Analogues of Zinpyr-1 provide insight into the mechanism of zinc sensing.
Inorganic chemistry 2006;45(16):6474-8.
2006: Zhao Min; Song Datong; Lippard Stephen J
Water induces a structural conversion and accelerates the oxygenation of carboxylate-bridged non-heme diiron enzyme synthetic analogues.
Inorganic chemistry 2006;45(16):6323-30.
2006: Smith Rhett C; Tennyson Andrew G; Lippard Stephen J
Polymer-bound dirhodium tetracarboxylate films for fluorescent detection of nitric oxide.
Inorganic chemistry 2006;45(16):6222-6.
2006: Yoon Sungho; Lippard Stephen J
Mechanistic studies of the oxidative N-dealkylation of a substrate tethered to carboxylate-bridged diiron(II) complexes, [Fe2(mu-O2CAr(Tol))2(O2CAr(Tol))2(N,N-Bn2en)2].
Inorganic chemistry 2006;45(14):5438-46.
2006: Lim Mi Hee; Xu Dong; Lippard Stephen J
Visualization of nitric oxide in living cells by a copper-based fluorescent probe.
Nature chemical biology 2006;2(7):375-80.
2006: Murray Leslie J; García-Serres Ricardo; Naik Sunil; Huynh Boi Hanh; Lippard Stephen J
Dioxygen activation at non-heme diiron centers: characterization of intermediates in a mutant form of toluene/o-xylene monooxygenase hydroxylase.
Journal of the American Chemical Society 2006;128(23):7458-9.
2006: Carson Emily C; Lippard Stephen J
Synthesis and oxidation of carboxylate-bridged diiron(II) complexes with substrates tethered to primary alkyl amine ligands.
Journal of inorganic biochemistry 2006;100(5-6):1109-17.
2006: Harrop Todd C; Song Datong; Lippard Stephen J
Interaction of nitric oxide with tetrathiolato iron(II) complexes: relevance to the reaction pathways of iron nitrosyls in sulfur-rich biological coordination environments.
Journal of the American Chemical Society 2006;128(11):3528-9.
2006: Nolan Elizabeth M; Racine Maryann E; Lippard Stephen J
Selective Hg(II) detection in aqueous solution with thiol derivatized fluoresceins.
Inorganic chemistry 2006;45(6):2742-9.
2006: Giblin Leonard J; Chang Christopher J; Bentley Anthony F; Frederickson Cathleen; Lippard Stephen J; Frederickson Christopher J
Zinc-secreting Paneth cells studied by ZP fluorescence.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006;54(3):311-6.
2006: Carson Emily C; Lippard Stephen J
Dioxygen-initiated oxidation of heteroatomic substrates incorporated into ancillary pyridine ligands of carboxylate-rich diiron(II) complexes.
Inorganic chemistry 2006;45(2):837-48.
2006: Carson Emily C; Lippard Stephen J
Synthesis, characterization, and preliminary oxygenation studies of benzyl- and ethyl-substituted pyridine ligands of carboxylate-rich diiron(II) complexes.
Inorganic chemistry 2006;45(2):828-36.
2006: Goldsmith Christian R; Lippard Stephen J
6-methylpyridyl for pyridyl substitution tunes the properties of fluorescent zinc sensors of the Zinpyr family.
Inorganic chemistry 2006;45(2):555-61.
2006: Goldsmith Christian R; Jaworski Jacek; Sheng Morgan; Lippard Stephen J
Selective labeling of extracellular proteins containing polyhistidine sequences by a fluorescein-nitrilotriacetic acid conjugate.
Journal of the American Chemical Society 2006;128(2):418-9.
2006: Jung Yongwon; Lippard Stephen J
RNA polymerase II blockage by cisplatin-damaged DNA. Stability and polyubiquitylation of stalled polymerase.
The Journal of biological chemistry 2006;281(3):1361-70.
2005: Blazyk Jessica L; Gassner George T; Lippard Stephen J
Intermolecular electron-transfer reactions in soluble methane monooxygenase: a role for hysteresis in protein function.
Journal of the American Chemical Society 2005;127(49):17364-76.
2005: Nolan Elizabeth M; Jaworski Jacek; Okamoto Ken-ichi; Hayashi Yasunori; Sheng Morgan; Lippard Stephen J
QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II).
Journal of the American Chemical Society 2005;127(48):16812-23.
2005: Beauvais Laurance G; Lippard Stephen J
Reactions of the diiron(IV) intermediate Q in soluble methane monooxygenase with fluoromethanes.
Biochemical and biophysical research communications 2005;338(1):262-6.
2005: Kodanko Jeremy J; Xu Dong; Song Datong; Lippard Stephen J
Iron substitution for sodium in a carboxylate-bridged, heterodinuclear sodium-iron complex.
Journal of the American Chemical Society 2005;127(46):16004-5.
2005: Kodanko Jeremy J; Morys Anna J; Lippard Stephen J
Synthesis of diethynyltriptycene-linked dipyridyl ligands.
Organic letters 2005;7(21):4585-8.
2005: Lim Mi Hee; Lippard Stephen J
Copper complexes for fluorescence-based NO detection in aqueous solution.
Journal of the American Chemical Society 2005;127(35):12170-1.
2005: Danford Andrew J; Wang Dong; Wang Qun; Tullius Thomas D; Lippard Stephen J
Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12311-6.
2005: Smith Rhett C; Tennyson Andrew G; Lim Mi Hee; Lippard Stephen J
Conjugated polymer-based fluorescence turn-on sensor for nitric oxide.
Organic letters 2005;7(16):3573-5.
2005: Rudd Deanne Jackson; Sazinsky Matthew H; Lippard Stephen J; Hedman Britt; Hodgson Keith O
X-ray absorption spectroscopic study of the reduced hydroxylases of methane monooxygenase and toluene/o-xylene monooxygenase: differences in active site structure and effects of the coupling proteins MMOB and ToMOD.
Inorganic chemistry 2005;44(13):4546-54.
2005: Yoon Sungho; Lippard Stephen J
Water affects the stereochemistry and dioxygen reactivity of carboxylate-rich diiron(II) models for the diiron centers in dioxygen-dependent non-heme enzymes.
Journal of the American Chemical Society 2005;127(23):8386-97.
2005: Beauvais Laurance G; Lippard Stephen J
Reactions of the peroxo intermediate of soluble methane monooxygenase hydroxylase with ethers.
Journal of the American Chemical Society 2005;127(20):7370-8.
2005: Woodroofe Carolyn C; Won Annie C; Lippard Stephen J
Esterase-activated two-fluorophore system for ratiometric sensing of biological zinc(II).
Inorganic chemistry 2005;44(9):3112-20.
2005: Lippard Stephen J
Hydroxylation of C-H bonds at carboxylate-bridged diiron centres.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2005;363(1829):861-77; discussion 1035-40.
2005: Sazinsky Matthew H; Lippard Stephen J
Product bound structures of the soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): protein motion in the alpha-subunit.
Journal of the American Chemical Society 2005;127(16):5814-25.
2005: Wang Dong; Lippard Stephen J
Cellular processing of platinum anticancer drugs.
Nature reviews. Drug discovery 2005;4(4):307-20.
2005: Lu Shen; Sazinsky Matthew H; Whittaker James W; Lippard Stephen J; Moënne-Loccoz Pierre
Fourier transform infrared characterization of the azido complex of methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath).
Journal of the American Chemical Society 2005;127(12):4148-9.
2005: Gherman Benjamin F; Lippard Stephen J; Friesner Richard A
Substrate hydroxylation in methane monooxygenase: quantitative modeling via mixed quantum mechanics/molecular mechanics techniques.
Journal of the American Chemical Society 2005;127(3):1025-37.
2004: Yoon Sungho; Lippard Stephen J
Water-dependent reactions of diiron(II) carboxylate complexes.
Journal of the American Chemical Society 2004;126(51):16692-3.
2004: Woodroofe Carolyn C; Masalha Rafik; Barnes Katie R; Frederickson Christopher J; Lippard Stephen J
Membrane-permeable and -impermeable sensors of the Zinpyr family and their application to imaging of hippocampal zinc in vivo.
Chemistry & biology 2004;11(12):1659-66.
2004: Sazinsky Matthew H; Merkx Maarten; Cadieux Elisabeth; Tang Sonya; Lippard Stephen J
Preparation and X-ray structures of metal-free, dicobalt and dimanganese forms of soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath).
Biochemistry 2004;43(51):16263-76.
2004: Nolan Elizabeth M; Lippard Stephen J
The zinspy family of fluorescent zinc sensors: syntheses and spectroscopic investigations.
Inorganic chemistry 2004;43(26):8310-7.
2004: Chang Christopher J; Nolan Elizabeth M; Jaworski Jacek; Okamoto Ken-ichi; Hayashi Yasunori; Sheng Morgan; Lippard Stephen J
ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy.
Inorganic chemistry 2004;43(21):6774-9.
2004: Lim Mi Hee; Lippard Stephen J
Fluorescence-based nitric oxide detection by ruthenium porphyrin fluorophore complexes.
Inorganic chemistry 2004;43(20):6366-70.
2004: Frederickson Christopher J; Burdette Shawn C; Frederickson Cathy J; Sensi Stefano L; Weiss John H; Yin Hong Z; Balaji Rengarajan V; Truong-Tran Ai Q; Bedell Eric; Prough Donald S; Lippard Stephen J
Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor.
Journal of neuroscience methods 2004;139(1):79-89.
2004: Chatwood Lisa L; Müller Jens; Gross John D; Wagner Gerhard; Lippard Stephen J
NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath).
Biochemistry 2004;43(38):11983-91.
2004: Hilderbrand Scott A; Lippard Stephen J
Nitric oxide reactivity of fluorophore coordinated carboxylate-bridged diiron(II) and dicobalt(II) complexes.
Inorganic chemistry 2004;43(17):5294-301.
2004: Hilderbrand Scott A; Lippard Stephen J
Cobalt chemistry with mixed aminotroponiminate salicylaldiminate ligands: synthesis, characterization, and nitric oxide reactivity.
Inorganic chemistry 2004;43(15):4674-82.
2004: Rudd Deanne Jackson; Sazinsky Matthew H; Merkx Maarten; Lippard Stephen J; Hedman Britt; Hodgson Keith O
Determination by X-ray absorption spectroscopy of the Fe-Fe separation in the oxidized form of the hydroxylase of methane monooxygenase alone and in the presence of MMOD.
Inorganic chemistry 2004;43(15):4579-89.
2004: Moreira Rayane F; Tshuva Edit Y; Lippard Stephen J
Catalytic oxidative ring opening of THF promoted by a carboxylate-bridged diiron complex, triarylphosphines, and dioxygen.
Inorganic chemistry 2004;43(14):4427-34.
2004: Sazinsky Matthew H; Bard Joel; Di Donato Alberto; Lippard Stephen J
Crystal structure of the toluene/o-xylene monooxygenase hydroxylase from Pseudomonas stutzeri OX1. Insight into the substrate specificity, substrate channeling, and active site tuning of multicomponent monooxygenases.
The Journal of biological chemistry 2004;279(29):30600-10.
2004: Zhang Christiana Xin; Chang Pamela V; Lippard Stephen J
Identification of nuclear proteins that interact with platinum-modified DNA by photoaffinity labeling.
Journal of the American Chemical Society 2004;126(21):6536-7.
2004: Wang Dong; Lippard Stephen J
Cisplatin-induced post-translational modification of histones H3 and H4.
The Journal of biological chemistry 2004;279(20):20622-5.
2004: Barnes Katie R; Kutikov Alexander; Lippard Stephen J
Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes.
Chemistry & biology 2004;11(4):557-64.
2004: Hilderbrand Scott A; Lim Mi Hee; Lippard Stephen J
Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors.
Journal of the American Chemical Society 2004;126(15):4972-8.
2004: Nolan Elizabeth M; Burdette Shawn C; Harvey Jessica H; Hilderbrand Scott A; Lippard Stephen J
Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform.
Inorganic chemistry 2004;43(8):2624-35.
2004: Carson Emily C; Lippard Stephen J
Oxidation of sulfide, phosphine, and benzyl substrates tethered to N-donor pyridine ligands in carboxylate-bridged diiron(II) complexes.
Journal of the American Chemical Society 2004;126(11):3412-3.
2004: Gherman Benjamin F; Baik Mu-Hyun; Lippard Stephen J; Friesner Richard A
Dioxygen activation in methane monooxygenase: a theoretical study.
Journal of the American Chemical Society 2004;126(9):2978-90.
2004: Yoon Sungho; Lippard Stephen J
Synthesis and characterization of carboxylate-rich complexes having the [Fe2(mu-OH)2(mu-O2CR)]3+ and [Fe2(mu-O)(mu-O2CR)]3+ cores of O2-dependent diiron enzymes.
Journal of the American Chemical Society 2004;126(9):2666-7.
2004: Kuzelka Jane; Mukhopadhyay Sumitra; Spingler Bernhard; Lippard Stephen J
Synthesis and characterization of Cu(2)(I,I), Cu(2)(I,II), and Cu(2)(II,II) compounds supported by two phthalazine-based ligands: influence of a hydrophobic pocket.
Inorganic chemistry 2004;43(5):1751-61.
2004: Chang Christopher J; Nolan Elizabeth M; Jaworski Jacek; Burdette Shawn C; Sheng Morgan; Lippard Stephen J
Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc.
Chemistry & biology 2004;11(2):203-10.
2004: Tshuva Edit Y; Lippard Stephen J
Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics.
Chemical reviews 2004;104(2):987-1012.
2004: Chang Christopher J; Jaworski Jacek; Nolan Elizabeth M; Sheng Morgan; Lippard Stephen J
A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1129-34.
2004: Blazyk Jessica L; Lippard Stephen J
Domain engineering of the reductase component of soluble methane monooxygenase from Methylococcus capsulatus (Bath).
The Journal of biological chemistry 2004;279(7):5630-40.
2004: Barnes Katie R; Lippard Stephen J
Cisplatin and related anticancer drugs: recent advances and insights.
Metal ions in biological systems 2004;42():143-77.
2003: Kuzelka Jane; Farrell Joshua R; Lippard Stephen J
Modeling the syn disposition of nitrogen donors at the active sites of carboxylate-bridged diiron enzymes. Enforcing dinuclearity and kinetic stability with a 1,2-diethynylbenzene-based ligand.
Inorganic chemistry 2003;42(26):8652-62.
2003: Baik Mu-Hyun; Friesner Richard A; Lippard Stephen J
cis-[Pt(NH3)2(L)]2+/+ (L = Cl, H2O, NH3) binding to purines and CO: does pi-back-donation play a role?
Inorganic chemistry 2003;42(26):8615-7.
2003: Yoon Sungho; Lippard Stephen J
Synthesis, characterization, and dioxygen reactivity of tetracarboxylate-bridged Diiron(II) complexes with coordinated substrates.
Inorganic chemistry 2003;42(26):8606-8.
2003: Jung Yongwon; Lippard Stephen J
Multiple states of stalled T7 RNA polymerase at DNA lesions generated by platinum anticancer agents.
The Journal of biological chemistry 2003;278(52):52084-92.
2003: Nolan Elizabeth M; Lippard Stephen J
A "turn-on" fluorescent sensor for the selective detection of mercuric ion in aqueous media.
Journal of the American Chemical Society 2003;125(47):14270-1.
2003: Baik Mu-Hyun; Friesner Richard A; Lippard Stephen J
Theoretical study of cisplatin binding to purine bases: why does cisplatin prefer guanine over adenine?
Journal of the American Chemical Society 2003;125(46):14082-92.
2003: Kuzelka Jane; Mukhopadhyay Sumitra; Spingler Bernhard; Lippard Stephen J
Modeling features of the non-heme diiron cores in O2-activating enzymes through the synthesis, characterization, and oxidation of 1,8-naphthyridine-based complexes.
Inorganic chemistry 2003;42(20):6447-57.
2003: Muthusamy Mylrajan; Ambundo Edna A; George Simon J; Lippard Stephen J; Thorneley Roger N F
Stopped-flow Fourier transform infrared spectroscopy of nitromethane oxidation by the diiron(IV) intermediate of methane monooxygenase.
Journal of the American Chemical Society 2003;125(37):11150-1.
2003: Woodroofe Carolyn C; Lippard Stephen J
A novel two-fluorophore approach to ratiometric sensing of Zn(2+).
Journal of the American Chemical Society 2003;125(38):11458-9.
2003: Zhang Christiana Xin; Lippard Stephen J
New metal complexes as potential therapeutics.
Current opinion in chemical biology 2003;7(4):481-9.
2003: Baik Mu-Hyun; Newcomb Martin; Friesner Richard A; Lippard Stephen J
Mechanistic studies on the hydroxylation of methane by methane monooxygenase.
Chemical reviews 2003;103(6):2385-419.
2003: Clark Matthew A; Duffy Kathryn; Tibrewala Jyoti; Lippard Stephen J
Synthesis and metal-binding properties of chelating fluorescein derivatives.
Organic letters 2003;5(12):2051-4.
2003: Wang Dong; Hara Ryujiro; Singh Gitanjali; Sancar Aziz; Lippard Stephen J
Nucleotide excision repair from site-specifically platinum-modified nucleosomes.
Biochemistry 2003;42(22):6747-53.
2003: Guallar Victor; Baik Mu-Hyun; Lippard Stephen J; Friesner Richard A
Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):6998-7002.
2003: Kopp Daniel A; Berg Eric A; Costello Catherine E; Lippard Stephen J
Structural features of covalently cross-linked hydroxylase and reductase proteins of soluble methane monooxygenase as revealed by mass spectrometric analysis.
The Journal of biological chemistry 2003;278(23):20939-45.
2003: Wirstam Maria; Lippard Stephen J; Friesner Richard A
Reversible dioxygen binding to hemerythrin.
Journal of the American Chemical Society 2003;125(13):3980-7.
2003: Burdette Shawn C; Lippard Stephen J
Meeting of the minds: metalloneurochemistry.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3605-10.
2003: Jung Yongwon; Lippard Stephen J
Nature of full-length HMGB1 binding to cisplatin-modified DNA.
Biochemistry 2003;42(9):2664-71.
2003: Boerzel Heidi; Koeckert Margery; Bu Weiming; Spingler Bernhard; Lippard Stephen J
Zinc-bound thiolate-disulfide exchange: a strategy for inhibiting metallo-beta-lactamases.
Inorganic chemistry 2003;42(5):1604-15.
2003: Burdette Shawn C; Frederickson Christopher J; Bu Weiming; Lippard Stephen J
ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family.
Journal of the American Chemical Society 2003;125(7):1778-87.
2003: Wei Min; Burenkova Olga; Lippard Stephen J
Cisplatin sensitivity in Hmbg1-/- and Hmbg1+/+ mouse cells.
The Journal of biological chemistry 2003;278(3):1769-73.
2002: Blazyk Jessica L; Lippard Stephen J
Expression and characterization of ferredoxin and flavin adenine dinucleotide binding domains of the reductase component of soluble methane monooxygenase from Methylococcus capsulatus (Bath).
Biochemistry 2002;41(52):15780-94.
2002: Burdette Shawn C; Lippard Stephen J
The rhodafluor family. An initial study of potential ratiometric fluorescent sensors for Zn2+.
Inorganic chemistry 2002;41(25):6816-23.
2002: Baik Mu-Hyun; Gherman Benjamin F; Friesner Richard A; Lippard Stephen J
Hydroxylation of methane by non-heme diiron enzymes: molecular orbital analysis of C-H bond activation by reactive intermediate Q.
Journal of the American Chemical Society 2002;124(49):14608-15.
2002: Silverman Adam P; Bu Weiming; Cohen Seth M; Lippard Stephen J
2.4-A crystal structure of the asymmetric platinum complex [Pt(ammine)(cyclohexylamine)]2+ bound to a dodecamer DNA duplex.
The Journal of biological chemistry 2002;277(51):49743-9.
2002: MacArthur Ryan; Sazinsky Matthew H; Kühne Henriette; Whittington Douglas A; Lippard Stephen J; Brudvig Gary W
Component B binding to the soluble methane monooxygenase hydroxylase by saturation-recovery EPR spectroscopy of spin-labeled MMOB.
Journal of the American Chemical Society 2002;124(45):13392-3.
2002: Kopp Daniel A; Lippard Stephen J
Soluble methane monooxygenase: activation of dioxygen and methane.
Current opinion in chemical biology 2002;6(5):568-76.
2002: Zamble Deborah B; Mikata Yuji; Eng Christina H; Sandman Karen E; Lippard Stephen J
Testis-specific HMG-domain protein alters the responses of cells to cisplatin.
Journal of inorganic biochemistry 2002;91(3):451-62.
2002: Ambundo Edna A; Friesner Richard A; Lippard Stephen J
Reactions of methane monooxygenase intermediate Q with derivatized methanes.
Journal of the American Chemical Society 2002;124(30):8770-1.
2002: Newcomb Martin; Shen Runnan; Lu Yun; Coon Minor J; Hollenberg Paul F; Kopp Daniel A; Lippard Stephen J
Evaluation of norcarane as a probe for radicals in cytochome p450- and soluble methane monooxygenase-catalyzed hydroxylation reactions.
Journal of the American Chemical Society 2002;124(24):6879-86.
2002: Lee Dongwhan; DuBois Jennifer L; Pierce Brad; Hedman Britt; Hodgson Keith O; Hendrich Michael P; Lippard Stephen J
Structural and spectroscopic studies of valence-delocalized diiron(II,III) complexes dupported by carboxylate-only bridging ligands.
Inorganic chemistry 2002;41(12):3172-82.
2002: Lee Dongwhan; Lippard Stephen J
Modeling dioxygen-activating centers in non-heme diiron enzymes: carboxylate shifts in diiron(II) complexes supported by sterically hindered carboxylate ligands.
Inorganic chemistry 2002;41(10):2704-19.
2002: Bino Avi; Ardon Michael; Lee Dongwhan; Spingler Bernhard; Lippard Stephen J
Synthesis and structure of [Fe(13)O(4)F(24)(OMe)(12)](5-): the first open-shell Keggin ion.
Journal of the American Chemical Society 2002;124(17):4578-9.
2002: Guallar Victor; Gherman Benjamin F; Lippard Stephen J; Friesner Richard A
Quantum chemical studies of methane monooxygenase: comparision with P450.
Current opinion in chemical biology 2002;6(2):236-42.
2002: Baik Mu-Hyun; Friesner Richard A; Lippard Stephen J
Theoretical study on the stability of N-glycosyl bonds: why does N7-platination not promote depurination?
Journal of the American Chemical Society 2002;124(16):4495-503.
2002: Lippard Stephen J
Chemical synthesis: the art of chemistry.
Nature 2002;416(6881):587.
2002: Lee Dongwhan; Pierce Brad; Krebs Carsten; Hendrich Michael P; Huynh Boi Hanh; Lippard Stephen J
Functional mimic of dioxygen-activating centers in non-heme diiron enzymes: mechanistic implications of paramagnetic intermediates in the reactions between diiron(II) complexes and dioxygen.
Journal of the American Chemical Society 2002;124(15):3993-4007.
2002: Guallar Victor; Gherman Benjamin F; Miller William H; Lippard Stephen J; Friesner Richard A
Dynamics of alkane hydroxylation at the non-heme diiron center in methane monooxygenase.
Journal of the American Chemical Society 2002;124(13):3377-84.
2002: Lee Keng-Boon; Wang Dong; Lippard Stephen J; Sharp Phillip A
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4239-44.
2002: Smoukov Stoyan K; Kopp Daniel A; Valentine Ann M; Davydov Roman; Lippard Stephen J; Hoffman Brian M
Product binding to the diiron(III) and mixed-valence diiron centers of methane monooxygenase hydroxylase studied by (1,2)H and (19)F ENDOR spectroscopy.
Journal of the American Chemical Society 2002;124(11):2657-63.
2002: Tshuva Edit Y; Lee Dongwhan; Bu Weiming; Lippard Stephen J
Catalytic oxidation by a carboxylate-bridged non-heme diiron complex.
Journal of the American Chemical Society 2002;124(11):2416-7.
2002: Lee Dongwhan; Lippard Stephen J
Synthetic analogue of the [Fe(2)(mu-OH)(2)(mu-O(2)CR)](3+) core of soluble methane monooxygenase hydroxylase via synthesis and dioxygen reactivity of carboxylate-bridged diiron(II) complexes.
Inorganic chemistry 2002;41(4):827-37.
2002: Lee Dongwhan; Hung Pei-Lin; Spingler Bernhard; Lippard Stephen J
Sterically hindered carboxylate ligands support water-bridged dimetallic centers that model features of metallohydrolase active sites.
Inorganic chemistry 2002;41(3):521-31.
2002: Merkx Maarten; Lippard Stephen J
Why OrfY? Characterization of MMOD, a long overlooked component of the soluble methane monooxygenase from Methylococcus capsulatus (Bath).
The Journal of biological chemistry 2002;277(8):5858-65.
2002: Müller Jens; Lugovskoy Alexey A; Wagner Gerhard; Lippard Stephen J
NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase.
Biochemistry 2002;41(1):42-51.
2001: Lee D; Sorace L; Caneschi A; Lippard S J
Hydroxo-bridged Cubane-type tetrairon(II) clusters supported by sterically-hindered carboxylate ligands.
Inorganic chemistry 2001;40(26):6774-81.
2001: Kopp D A; Gassner G T; Blazyk J L; Lippard S J
Electron-transfer reactions of the reductase component of soluble methane monooxygenase from Methylococcus capsulatus (Bath).
Biochemistry 2001;40(49):14932-41.
2001: Jung Y; Mikata Y; Lippard S J
Kinetic studies of the TATA-binding protein interaction with cisplatin-modified DNA.
The Journal of biological chemistry 2001;276(47):43589-96.
2001: Spingler B; Whittington D A; Lippard S J
2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.
Inorganic chemistry 2001;40(22):5596-602.
2001: Wei M; Cohen S M; Silverman A P; Lippard S J
Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins.
The Journal of biological chemistry 2001;276(42):38774-80.
2001: Mizoguchi T J; Kuzelka J; Spingler B; DuBois J L; Davydov R M; Hedman B; Hodgson K O; Lippard S J
Synthesis and spectroscopic studies of non-heme diiron(III) species with a terminal hydroperoxide ligand: models for hemerythrin.
Inorganic chemistry 2001;40(18):4662-73.
2001: Mareque Rivas J C; Schwalbe H; Lippard S J
Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9478-83.
2001: Burdette S C; Walkup G K; Spingler B; Tsien R Y; Lippard S J
Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution.
Journal of the American Chemical Society 2001;123(32):7831-41.
2001: Franz K J; Doerrer L H; Spingler B; Lippard S J
Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds.
Inorganic chemistry 2001;40(15):3774-80.
2001: Kaminskaia N V; Spingler B; Lippard S J
Intermediate in beta-lactam hydrolysis catalyzed by a dinuclear zinc(II) complex: relevance to the mechanism of metallo-beta-lactamase.
Journal of the American Chemical Society 2001;123(27):6555-63.
2001: Yarnell A T; Oh S; Reinberg D; Lippard S J
Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin.
The Journal of biological chemistry 2001;276(28):25736-41.
2001: Mikata Y; He Q; Lippard S J
Laser-induced photo-cross-linking of cisplatin-modified DNA to HMG-domain proteins.
Biochemistry 2001;40(25):7533-41.
2001: Lee D; Lippard S J
Oxidative N-dealkylation of a carboxylate-bridged diiron(II) precursor complex by reaction with O2 affords the elusive [Fe2(mu-OH)2(mu-O2CR)](3+) core of soluble methane monooxygenase hydroxylase.
Journal of the American Chemical Society 2001;123(19):4611-2.
2001: Gherman B F; Dunietz B D; Whittington D A; Lippard S J; Friesner R A
Activation of the C-H bond of methane by intermediate Q of methane monooxygenase: a theoretical study.
Journal of the American Chemical Society 2001;123(16):3836-7.
2001: Barrios A M; Lippard S J
Decomposition of alkyl-substituted urea molecules at a hydroxide-bridged dinickel center.
Inorganic chemistry 2001;40(6):1250-5.
2001: Whittington D A; Rosenzweig A C; Frederick C A; Lippard S J
Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase.
Biochemistry 2001;40(12):3476-82.
2001: He C; Lippard S J
Synthesis and electrochemical studies of diiron complexes of 1,8-naphthyridine-based dinucleating ligands to model features of the active sites of non-heme diiron enzymes.
Inorganic chemistry 2001;40(7):1414-20.
2001: Whittington D A; Sazinsky M H; Lippard S J
X-ray crystal structure of alcohol products bound at the active site of soluble methane monooxygenase hydroxylase.
Journal of the American Chemical Society 2001;123(8):1794-5.
2001: Whittington D A; Lippard S J
Crystal structures of the soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath) demonstrating geometrical variability at the dinuclear iron active site.
Journal of the American Chemical Society 2001;123(5):827-38.
2001: Barrios A M; Lippard S J
Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites.
Inorganic chemistry 2001;40(5):1060-4.
2001: Stahl S S; Francisco W A; Merkx M; Klinman J P; Lippard S J
Oxygen kinetic isotope effects in soluble methane monooxygenase.
The Journal of biological chemistry 2001;276(7):4549-53.
2001: Cohen S M; Lippard S J
Cisplatin: from DNA damage to cancer chemotherapy.
Progress in nucleic acid research and molecular biology 2001;67():93-130.
2000: Ziegler C J; Silverman A P; Lippard S J
High-throughput synthesis and screening of platinum drug candidates.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(6):774-83.
2000: He C; Lippard S J
Synthesis and characterization of several dicopper(I) complexes and a spin-delocalized dicopper(I,II) mixed-valence complex using a 1,8-naphthyridine-based dinucleating ligand.
Inorganic chemistry 2000;39(23):5225-31.
2000: He Q; Ohndorf U M; Lippard S J
Intercalating residues determine the mode of HMG1 domains A and B binding to cisplatin-modified DNA.
Biochemistry 2000;39(47):14426-35.
2000: Burstyn J N; Heiger-Bernays W J; Cohen S M; Lippard S J
Formation of cis-diamminedichloroplatinum(II) 1,2-intrastrand cross-links on DNA is flanking-sequence independent.
Nucleic acids research 2000;28(21):4237-43.
2000: Franz K J; Singh N; Spingler B; Lippard S J
Aminotroponiminates as ligands for potential metal-based nitric oxide sensors.
Inorganic chemistry 2000;39(18):4081-92.
2000: He C; Gomez V; Spingler B; Lippard S J
Monodentate-bridged phosphodiester and sulfate complexes: structural insights into the biological activation of phosphodiesters, sulfate, and sulfate esters.
Inorganic chemistry 2000;39(19):4188-9.
2000: Cohen S M; Mikata Y; He Q; Lippard S J
HMG-domain protein recognition of cisplatin 1,2-intrastrand d(GpG) cross-links in purine-rich sequence contexts.
Biochemistry 2000;39(38):11771-6.
2000: Franz K J; Lippard S J
Nitrosyl transfer from manganese to iron in tropocoronand complexes.
Inorganic chemistry 2000;39(16):3722-3.
2000: Zhang X X; Lippard S J
Synthesis of PDK, a novel porphyrin-linked dicarboxylate ligand.
The Journal of organic chemistry 2000;65(17):5298-305.
2000: Kaminskaia N V; He C; Lippard S J
Reactivity of mu-hydroxodizinc(II) centers in enzymatic catalysis through model studies.
Inorganic chemistry 2000;39(15):3365-73.
2000: Jamieson E R; Lippard S J
Stopped-flow fluorescence studies of HMG-domain protein binding to cisplatin-modified DNA.
Biochemistry 2000;39(29):8426-38.
2000: Cohen S M; Jamieson E R; Lippard S J
Enhanced binding of the TATA-binding protein to TATA boxes containing flanking cisplatin 1,2-cross-links.
Biochemistry 2000;39(28):8259-65.
2000: He Q; Liang C H; Lippard S J
Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5768-72.
2000: Coufal D E; Blazyk J L; Whittington D A; Wu W W; Rosenzweig A C; Lippard S J
Sequencing and analysis of the Mmethylococcus capsulatus (Bath) solublemethane monooxygenase genes.
European journal of biochemistry / FEBS 2000;267(8):2174-85.
1999: Gassner G T; Lippard S J
Component interactions in the soluble methane monooxygenase system from Methylococcus capsulatus (Bath).
Biochemistry 1999;38(39):12768-85.
1999: Ziegler C J; Sandman K E; Liang C H; Lippard S J
Toxicity of platinum(II) amino acid (N,O) complexes parallels their binding to DNA as measured in a new solid phase assay involving a fluorescent HMG1 protein construct readout.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(4):402-11.
1999: Sandman K E; Marla S S; Zlokarnik G; Lippard S J
Rapid fluorescence-based reporter-gene assays to evaluate the cytotoxicity and antitumor drug potential of platinum complexes.
Chemistry & biology 1999;6(8):541-51.
1999: Brandstetter H; Whittington D A; Lippard S J; Frederick C A
Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath).
Chemistry & biology 1999;6(7):441-9.
1999: Ohndorf U M; Rould M A; He Q; Pabo C O; Lippard S J
Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins.
Nature 1999;399(6737):708-12.
1999: LeCloux D D; Barrios A M; Lippard S J
The reactivity of well defined diiron(III) peroxo complexes toward substrates: addition to electrophiles and hydrocarbon oxidation.
Bioorganic & medicinal chemistry 1999;7(5):763-72.
1999: Lippard S J
Free copper ions in the cell?
Science (New York, N.Y.) 1999;284(5415):748-9.
1999: Jamieson E R; Jacobson M P; Barnes C M; Chow C S; Lippard S J
Structural and kinetic studies of a cisplatin-modified DNA icosamer binding to HMG1 domain B.
The Journal of biological chemistry 1999;274(18):12346-54.
1999: Valentine A M; LeTadic-Biadatti M H; Toy P H; Newcomb M; Lippard S J
Oxidation of ultrafast radical clock substrate probes by the soluble methane monooxygenase from Methylococcus capsulatus (Bath).
The Journal of biological chemistry 1999;274(16):10771-6.
1999: Coufal D E; Tavares P; Pereira A S; Hyunh B H; Lippard S J
Reactions of nitric oxide with the reduced non-heme diiron center of the soluble methane monooxygenase hydroxylase.
Biochemistry 1999;38(14):4504-13.
1999: Davydov R; Valentine A M; Komar-Panicucci S; Hoffman B M; Lippard S J
An EPR study of the dinuclear iron site in the soluble methane monooxygenase from Methylococcus capsulatus (Bath) reduced by one electron at 77 K: the effects of component interactions and the binding of small molecules to the diiron(III) center.
Biochemistry 1999;38(13):4188-97.
1998: Gelasco A; Lippard S J
NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin.
Biochemistry 1998;37(26):9230-9.
1998: Zamble D B; Jacks T; Lippard S J
p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6163-8.
1998: Ishibashi T; Lippard S J
Telomere loss in cells treated with cisplatin.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4219-23.
1998: Trimmer E E; Zamble D B; Lippard S J; Essigmann J M
Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities.
Biochemistry 1998;37(1):352-62.
1997: Ohndorf U M; Whitehead J P; Raju N L; Lippard S J
Binding of tsHMG, a mouse testis-specific HMG-domain protein, to cisplatin-DNA adducts.
Biochemistry 1997;36(48):14807-15.
1997: Rosenzweig A C; Brandstetter H; Whittington D A; Nordlund P; Lippard S J; Frederick C A
Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Proteins 1997;29(2):141-52.
1997: Dunham S U; Lippard S J
DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA.
Biochemistry 1997;36(38):11428-36.
1996: Zamble D B; Mu D; Reardon J T; Sancar A; Lippard S J
Repair of cisplatin--DNA adducts by the mammalian excision nuclease.
Biochemistry 1996;35(31):10004-13.
1996: McA'Nulty M M; Whitehead J P; Lippard S J
Binding of Ixr1, a yeast HMG-domain protein, to cisplatin-DNA adducts in vitro and in vivo.
Biochemistry 1996;35(19):6089-99.
1996: Kane S A; Lippard S J
Photoreactivity of platinum(II) in cisplatin-modified DNA affords specific cross-links to HMG domain proteins.
Biochemistry 1996;35(7):2180-8.
1996: McA'Nulty M M; Lippard S J
The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast.
Mutation research 1996;362(1):75-86.
1996: Whitehead J P; Lippard S J
Proteins that bind to and mediate the biological activity of platinum anticancer drug-DNA adducts.
Metal ions in biological systems 1996;32():687-726.
1995: Mello J A; Lippard S J; Essigmann J M
DNA adducts of cis-diamminedichloroplatinum(II) and its trans isomer inhibit RNA polymerase II differentially in vivo.
Biochemistry 1995;34(45):14783-91.
1995: Zamble D B; Lippard S J
Cisplatin and DNA repair in cancer chemotherapy.
Trends in biochemical sciences 1995;20(10):435-9.
1995: Takahara P M; Rosenzweig A C; Frederick C A; Lippard S J
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.
Nature 1995;377(6550):649-52.
1995: Yarema K J; Lippard S J; Essigmann J M
Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).
Nucleic acids research 1995;23(20):4066-72.
1995: Rosenzweig A C; Nordlund P; Takahara P M; Frederick C A; Lippard S J
Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states.
Chemistry & biology 1995;2(9):409-18.
1995: Rosenzweig A C; Nordlund P; Takahara P M; Frederick C A; Lippard S J
Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states.
Chemistry & biology 1995;2(6):409-18.
1995: Lippard S J
At last--the crystal structure of urease.
Science (New York, N.Y.) 1995;268(5213):996-7.
1995: Chow C S; Barnes C M; Lippard S J
A single HMG domain in high-mobility group 1 protein binds to DNAs as small as 20 base pairs containing the major cisplatin adduct.
Biochemistry 1995;34(9):2956-64.
1994: Chow C S; Whitehead J P; Lippard S J
HMG domain proteins induce sharp bends in cisplatin-modified DNA.
Biochemistry 1994;33(50):15124-30.
1994: Huang J C; Zamble D B; Reardon J T; Lippard S J; Sancar A
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10394-8.
1994: Yarema K J; Wilson J M; Lippard S J; Essigmann J M
Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.
Journal of molecular biology 1994;236(4):1034-48.
1993: Rosenzweig A C; Frederick C A; Lippard S J; Nordlund P
Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane.
Nature 1993;366(6455):537-43.
1993: Pil P M; Chow C S; Lippard S J
High-mobility-group 1 protein mediates DNA bending as determined by ring closures.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9465-9.
1993: Lippard S J
Bioinorganic chemistry: a maturing frontier.
Science (New York, N.Y.) 1993;261(5122):699-700.
1993: Brown S J; Kellett P J; Lippard S J
Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin.
Science (New York, N.Y.) 1993;261(5121):603-5.
1993: Bruhn S L; Housman D E; Lippard S J
Isolation and characterization of cDNA clones encoding the Drosophila homolog of the HMG-box SSRP family that recognizes specific DNA structures.
Nucleic acids research 1993;21(7):1643-6.
1993: Taft K L; Papaefthymiou G C; Lippard S J
A mixed-valent polyiron oxo complex that models the biomineralization of the ferritin core.
Science (New York, N.Y.) 1993;259(5099):1302-5.
1993: Bradley L J; Yarema K J; Lippard S J; Essigmann J M
Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II).
Biochemistry 1993;32(3):982-8.
1992: Szymkowski D E; Yarema K; Essigmann J M; Lippard S J; Wood R D
An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10772-6.
1992: Rosenzweig A C; Frederick C A; Lippard S J
Crystallization and preliminary X-ray analysis of the methane monooxygenase hydroxylase protein from Methylococcus capsulatus (Bath).
Journal of molecular biology 1992;227(2):583-5.
1992: Pil P M; Lippard S J
Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin.
Science (New York, N.Y.) 1992;256(5054):234-7.
1992: Comess K M; Burstyn J N; Essigmann J M; Lippard S J
Replication inhibition and translesion synthesis on templates containing site-specifically placed cis-diamminedichloroplatinum(II) DNA adducts.
Biochemistry 1992;31(16):3975-90.
1992: Bruhn S L; Pil P M; Essigmann J M; Housman D E; Lippard S J
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2307-11.
1991: Bellon S F; Coleman J H; Lippard S J
DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II).
Biochemistry 1991;30(32):8026-35.
1991: Liu K E; Lippard S J
Redox properties of the hydroxylase component of methane monooxygenase from Methylococcus capsulatus (Bath). Effects of protein B, reductase, and substrate.
The Journal of biological chemistry 1991;266(20):12836-9.
1991: Hollis L S; Sundquist W I; Burstyn J N; Heiger-Bernays W J; Bellon S F; Ahmed K J; Amundsen A R; Stern E W; Lippard S J
Mechanistic studies of a novel class of trisubstituted platinum(II) antitumor agents.
Cancer research 1991;51(7):1866-75.
1990: Heiger-Bernays W J; Essigmann J M; Lippard S J
Effect of the antitumor drug cis-diamminedichloroplatinum(II) and related platinum complexes on eukaryotic DNA replication.
Biochemistry 1990;29(36):8461-6.
1990: Donahue B A; Augot M; Bellon S F; Treiber D K; Toney J H; Lippard S J; Essigmann J M
Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin.
Biochemistry 1990;29(24):5872-80.
1990: Bellon S F; Lippard S J
Bending studies of DNA site-specifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-[Pt(NH3)2(N3-cytosine)Cl]+.
Biophysical chemistry 1990;35(2-3):179-88.
1990: Comess K M; Costello C E; Lippard S J
Identification and characterization of a novel linkage isomerization in the reaction of trans-diamminedichloroplatinum(II) with 5'-d(TCTACGCGTTCT).
Biochemistry 1990;29(8):2102-10.
1990: Lepre C A; Chassot L; Costello C E; Lippard S J
Synthesis and characterization of trans-[Pt(NH3)2Cl2] adducts of d(CCTCGAGTCTCC).d(GGAGACTCGAGG).
Biochemistry 1990;29(3):811-23.
1989: Toney J H; Donahue B A; Kellett P J; Bruhn S L; Essigmann J M; Lippard S J
Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8328-32.
1988: Rice J A; Crothers D M; Pinto A L; Lippard S J
The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4158-61.
1988: Naser L J; Pinto A L; Lippard S J; Essigmann J M
Chemical and biological studies of the major DNA adduct of cis-diamminedichloroplatinum(II), cis-[Pt(NH3)2(d(GpG]], built into a specific site in a viral genome.
Biochemistry 1988;27(12):4357-67.
1987: Sundquist W I; Lippard S J; Stollar B D
Monoclonal antibodies to DNA modified with cis- or trans-diamminedichloroplatinum(II).
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8225-9.
1987: Lepre C A; Strothkamp K G; Lippard S J
Synthesis and 1H NMR spectroscopic characterization of trans-[Pt(NH3)2[d(ApGpGpCpCpT)-N7-A(1),N7-G(3)]].
Biochemistry 1987;26(18):5651-7.
1987: O'Halloran T V; Lippard S J; Richmond T J; Klug A
Multiple heavy-atom reagents for macromolecular X-ray structure determination. Application to the nucleosome core particle.
Journal of molecular biology 1987;194(4):705-12.
1986: Sundquist W I; Lippard S J; Stollar B D
Binding of cis- and trans-diamminedichloroplatinum(II) to deoxyribonucleic acid exposes nucleosides as measured immunochemically with anti-nucleoside antibodies.
Biochemistry 1986;25(7):1520-4.
1985: Pinto A L; Lippard S J
Sequence-dependent termination of in vitro DNA synthesis by cis- and trans-diamminedichloroplatinum (II).
Proceedings of the National Academy of Sciences of the United States of America 1985;82(14):4616-9.
1985: Pinto A L; Lippard S J
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
Biochimica et biophysica acta 1985;780(3):167-80.

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