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John Lipscomb

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TOP 3
M E Bette Meek; John C Lipscomb; Hugh A Barton; Jos G Bessems; Kannan Krishnan
Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment.
Weihsueh A Chiu; Glinda S Cooper; Rebecca C Dzubow; Marina V Evans; John F Fox; Kathryn Z Guyton; Maureen R Gwinn; Jennifer Jinot; Nagalakshmi Keshava; John C Lipscomb; Susan L Makris; John Schaum; Cheryl Siegel Scott; Ambuja S Bale; Stanley Barone; Jane C Caldwell
Human health effects of trichloroethylene: key findings and scientific issues.
Alan F Sasso; Paul M Schlosser; John E Snawder; Susan Rieth; Mary Beth Genter; Gregory L Kedderis; Zheng Li; John C Lipscomb
Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice.

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All Publications

2013: M E Bette Meek; John C Lipscomb; Hugh A Barton; Jos G Bessems; Kannan Krishnan
Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment.
Regulatory toxicology and pharmacology : RTP 2013;66(1):116-29.
2013: Weihsueh A Chiu; Glinda S Cooper; Rebecca C Dzubow; Marina V Evans; John F Fox; Kathryn Z Guyton; Maureen R Gwinn; Jennifer Jinot; Nagalakshmi Keshava; John C Lipscomb; Susan L Makris; John Schaum; Cheryl Siegel Scott; Ambuja S Bale; Stanley Barone; Jane C Caldwell
Human health effects of trichloroethylene: key findings and scientific issues.
Environmental health perspectives 2013;121(3):303-11.
2013: Alan F Sasso; Paul M Schlosser; John E Snawder; Susan Rieth; Mary Beth Genter; Gregory L Kedderis; Zheng Li; John C Lipscomb
Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(2):360-74.
2012: John C Lipscomb; Torka Poet; Sami Haddad; Kannan Krishnan
Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment.
Advances in experimental medicine and biology 2012;745():76-95.
2011: Joan Colman; Margaret Fransen; Richard C Hertzberg; E Sidney Hunter; John C Lipscomb; Mark Osier; Glenn E Rice; Jane Ellen Simmons; Linda K Teuschler; J Michael Wright; Michael G Narotsky
Identification of developmentally toxic drinking water disinfection byproducts and evaluation of data relevant to mode of action.
Toxicology and applied pharmacology 2011;254(2):100-26.
2008: Chad M Thompson; Babasaheb Sonawane; Hugh A Barton; Robert S DeWoskin; John C Lipscomb; Paul Schlosser; Weihsueh A Chiu; Kannan Krishnan
Approaches for applications of physiologically based pharmacokinetic models in risk assessment.
Journal of toxicology and environmental health. Part B, Critical reviews 2008;11(7):519-47.
2008: John C Lipscomb; Torka S Poet
In vitro measurements of metabolism for application in pharmacokinetic modeling.
Pharmacology & therapeutics 2008;118(1):82-103.
2007: Deirdre A Mahle; Jeffery M Gearhart; Claude C Grigsby; David R Mattie; Hugh A Barton; John C Lipscomb; Robert S Cook
Age-dependent partition coefficients for a mixture of volatile organic solvents in Sprague-Dawley rats and humans.
Journal of toxicology and environmental health. Part A 2007;70(20):1745-51.
2007: Christopher S Mazur; John F Kenneke; Caroline Tebes-Stevens; Miles S Okino; John C Lipscomb
In vitro metabolism of the fungicide and environmental contaminant trans-bromuconazole and implications for risk assessment.
Journal of toxicology and environmental health. Part A 2007;70(14):1241-50.
2007: Chester E Rodriguez; Deirdre A Mahle; Jeffery M Gearhart; David R Mattie; John C Lipscomb; Robert S Cook; Hugh A Barton
Predicting age-appropriate pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically based pharmacokinetic modeling.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):43-56.
2007: Weihsueh A Chiu; Hugh A Barton; Robert S DeWoskin; Paul Schlosser; Chad M Thompson; Babasaheb Sonawane; John C Lipscomb; Kannan Krishnan
Evaluation of physiologically based pharmacokinetic models for use in risk assessment.
Journal of applied toxicology : JAT 2007;27(3):218-37.
2006: Weihsueh A Chiu; Miles S Okino; John C Lipscomb; Marina V Evans
Issues in the pharmacokinetics of trichloroethylene and its metabolites.
Environmental health perspectives 2006;114(9):1450-6.
2004: Linda K Teuschler; Glenn E Rice; Charles R Wilkes; John C Lipscomb; Fred W Power
A feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures.
Journal of toxicology and environmental health. Part A 2004;67(8-10):755-77.
2004: John C Lipscomb; Hugh A Barton; Rogelio Tornero-Velez; Marina V Evans; Sattar Alcasey; John E Snawder; John Laskey
The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform.
Journal of toxicology and environmental health. Part A 2004;67(7):537-53.
2004: John C Lipscomb; M E Bette Meek; Kannan Krishnan; Gregory L Kedderis; Harvey Clewell; Lynne Haber
Incorporation of pharmacokinetic and pharmacodynamic data into risk assessments.
Toxicology mechanisms and methods 2004;14(3):145-58.
2003: John C Lipscomb; Linda K Teuschler; Jeff Swartout; Doug Popken; Tony Cox; Gregory L Kedderis
The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans.
Risk analysis : an official publication of the Society for Risk Analysis 2003;23(6):1221-38.
2003: CJ Moudgal; R Venkatapathy; Harlal Choudhury; RM Bruce; John C Lipscomb
Application of QSTRs in the selection of a surrogate toxicity value for a chemical of concern.
Environmental science & technology 2003;37(22):5228-35.
2003: John C Lipscomb; Linda K Teuschler; Jeff Swartout; Cynthia A F Striley; John E Snawder
Variance of Microsomal Protein and Cytochrome P450 2E1 and 3A Forms in Adult Human Liver.
Toxicology mechanisms and methods 2003;13(1):45-51.
2002: John C Lipscomb; Gregory L Kedderis
Incorporating human interindividual biotransformation variance in health risk assessment.
The Science of the total environment 2002;288(1-2):13-21.
2001: Janusz Byczkowski; John C Lipscomb
Physiologically based pharmacokinetic modeling of the lactational transfer of methylmercury.
Risk analysis : an official publication of the Society for Risk Analysis 2001;21(5):869-82.
2001: Gregory L Kedderis; John C Lipscomb
Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment.
Toxicology and industrial health 2001;17(5-10):315-21.
2000: John E Snawder; John C Lipscomb
Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment.
Regulatory toxicology and pharmacology : RTP 2000;32(2):200-9.
2000: CJ Moudgal; John C Lipscomb; RM Bruce
Potential health effects of drinking water disinfection by-products using quantitative structure toxicity relationship.
Toxicology 2000;147(2):109-31.
2000: Lawrence H Lash; Jeffrey W Fisher; John C Lipscomb; Jean C Parker
Metabolism of trichloroethylene.
Environmental health perspectives 2000;108 Suppl 2():177-200.
2000: Linda K Teuschler; Chris Gennings; WM Stiteler; Richard C Hertzberg; J T Colman; Arunthavarani Thiyagarajah; John C Lipscomb; William R Hartley; Jane Ellen Simmons
A multiple-purpose design approach to the evaluation of risks from mixtures of disinfection by-products.
Drug and chemical toxicology 2000;23(1):307-21.
1999: Lawrence H Lash; John C Lipscomb; David A Putt; Jean C Parker
Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):351-9.
1998: John C Lipscomb; Jeffrey W Fisher; P D Confer; Janusz Byczkowski
In vitro to in vivo extrapolation for trichloroethylene metabolism in humans.
Toxicology and applied pharmacology 1998;152(2):376-87.
1997: A P Moghaddam; R Abbas; Jeffrey W Fisher; John C Lipscomb
The role of mouse intestinal microflora in the metabolism of trichloroethylene, an in vivo study.
Human & experimental toxicology 1997;16(11):629-35.
1997: John C Lipscomb; G W Buttler; P D Confer
Chloral hydrate formation in the Japanese medaka minnow.
Annals of clinical and laboratory science 1997;27(2):157-62.
1997: John C Lipscomb; C M Garrett; John E Snawder
Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans.
Toxicology and applied pharmacology 1997;142(2):311-8.
1996: John C Lipscomb; D A Mahle; W T Brashear; C M Garrett
A species comparison of chloral hydrate metabolism in blood and liver.
Biochemical and biophysical research communications 1996;227(2):340-50.
1996: H A Barton; C D Flemming; John C Lipscomb
Evaluating human variability in chemical risk assessment: hazard identification and dose-response assessment for noncancer oral toxicity of trichloroethylene.
Toxicology 1996;111(1-3):271-87.
1995: John C Lipscomb; D A Mahle; W T Brashear; H A Barton
Dichloroacetic acid: metabolism in cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(11):1202-5.