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William Lipscomb

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William N Lipscomb; Evan R Kantrowitz
Structure and mechanisms of Escherichia coli aspartate transcarbamoylase.
Qun Dang; Srinivas Rao Kasibhatla; K Raja Reddy; Tao Jiang; M Rami Reddy; Scott C Potter; James M Fujitaki; Paul D Van Poelje; Jingwei Huang; William N Lipscomb; Mark D Erion
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
Mark D Erion; Qun Dang; M Rami Reddy; Srinivas Rao Kasibhatla; Jingwei Huang; William N Lipscomb; Paul D Van Poelje
Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity.

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All Publications

2012: William N Lipscomb; Evan R Kantrowitz
Structure and mechanisms of Escherichia coli aspartate transcarbamoylase.
Accounts of chemical research 2012;45(3):444-53.
2007: Qun Dang; Srinivas Rao Kasibhatla; K Raja Reddy; Tao Jiang; M Rami Reddy; Scott C Potter; James M Fujitaki; Paul D Van Poelje; Jingwei Huang; William N Lipscomb; Mark D Erion
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
Journal of the American Chemical Society 2007;129(50):15491-502.
2007: Mark D Erion; Qun Dang; M Rami Reddy; Srinivas Rao Kasibhatla; Jingwei Huang; William N Lipscomb; Paul D Van Poelje
Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity.
Journal of the American Chemical Society 2007;129(50):15480-90.
2007: Hongzhi Li; Donghong Min; Sheldon G Shore; William N Lipscomb; Wei Yang
Nature of "hydrogen bond" in the diborane-benzene complex: covalent, electrostatic, or dispersive?
Inorganic chemistry 2007;46(10):3956-9.
2007: Silke Busch; Elke U Schwier; Krystyna Nahlik; Ozgür Bayram; Kerstin Helmstaedt; Oliver W Draht; Sven Krappmann; Oliver Valerius; William N Lipscomb; Gerhard H Braus
An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8089-94.
2006: Yifei Kong; Jianpeng Ma; Martin Karplus; William N Lipscomb
The allosteric mechanism of yeast chorismate mutase: a dynamic analysis.
Journal of molecular biology 2006;356(1):237-47.
2006: Jingwei Huang; William N Lipscomb
T-state active site of aspartate transcarbamylase: crystal structure of the carbamyl phosphate and L-alanosine ligated enzyme.
Biochemistry 2006;45(2):346-52.
2005: Kerstin Helmstaedt; Axel Strittmatter; William N Lipscomb; Gerhard H Braus
Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9784-9.
2005: Mark D Erion; Paul D Van Poelje; Qun Dang; Srinivas Rao Kasibhatla; Scott C Potter; M Rami Reddy; K Raja Reddy; Tao Jiang; William N Lipscomb
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7970-5.
2004: Jingwei Huang; William N Lipscomb
Products in the T-state of aspartate transcarbamylase: crystal structure of the phosphate and N-carbamyl-L-aspartate ligated enzyme.
Biochemistry 2004;43(21):6422-6.
2004: Jingwei Huang; William N Lipscomb
Aspartate transcarbamylase (ATCase) of Escherichia coli: a new crystalline R-state bound to PALA, or to product analogues citrate and phosphate.
Biochemistry 2004;43(21):6415-21.
2003: Hong Guo; Qiang Cui; William N Lipscomb; Martin Karplus
Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations.
Angewandte Chemie (International ed. in English) 2003;42(13):1508-11.
2003: Markus Hartmann; Thomas R Schneider; Andrea Pfeil; Gabriele Heinrich; William N Lipscomb; Gerhard H Braus
Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):862-7.
2002: Kerstin Helmstaedt; Gabriele Heinrich; William N Lipscomb; Gerhard H Braus
Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6631-6.
2001: Hua Guo; Qiang Cui; William N Lipscomb; Martin Karplus
Substrate conformational transitions in the active site of chorismate mutase: their role in the catalytic mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9032-7.
2001: K J Arrow; Julius Axelrod; franccesca villella; P Berg; John M Bishop; N Bloembergen; Herbert C Brown; J Cibelli; S Cohen; L N Cooper; E J Corey; J W Cronin; Robert F Curl; R Dulbecco; E H Fischer; V L Fitch; Robert W Fogel; J I Friedman; R F Furchgott; M Gell-Mann; W Gilbert; A Gilman; D Glaser; S L Glashow; R M Green; Paul Greengard; Roger Guillemin; L Hayflick; Herbert A Hauptman; J J Heckman; Alan J Heeger; Dudley R Herschbach; David H Hubel; R Hulse; Eric R Kandel; Jerome Karle; L R Klein; W Kohn; A Kornberg; Edwin G Krebs; R P Lanza; R Laughlin; L Lederman; D M Lee; E Lewis; William N Lipscomb; R A Marcus; D McFadden; RB Merrifield; R Merton; F Modigliani; M J Molina; F Murad; Marshall Nirenberg; D C North; George A Olah; D Osheroff; GE Palade; M Perl; N F Ramsey; B Richter; Richard J Roberts; P A Samuelson; M Schwartz; Phillip A Sharp; Richard E Smalley; Hamilton O Smith; R M Solow; H Stormer; H Taube; R Taylor; ED Thomas; J Tobin; Susumu Tonegawa; C Townes; James D Watson; S Weinberg; T H Weller; M D West; Eric Wieschaus; Torsten N Wiesel; R W Wilson
Nobel laureates' letter to President Bush.
Washington post (Washington, D.C. : 1974) 2001;():A02.
2000: Sven Krappmann; William N Lipscomb; Gerhard H Braus
Coevolution of transcriptional and allosteric regulation at the chorismate metabolic branch point of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13585-90.
1999: L Jin; Boguslaw Stec; William N Lipscomb; Evan R Kantrowitz
Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A.
Proteins 1999;37(4):729-42.
1999: Norbert Sträter; L Sun; Evan R Kantrowitz; William N Lipscomb
A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11151-5.
1998: Jianpeng Ma; X Zheng; G Schnappauf; Gerhard H Braus; Martin Karplus; William N Lipscomb
Yeast chorismate mutase in the R state: simulations of the active site.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14640-5.
1998: YuhMin Chook; William N Lipscomb; Hengming Ke
Detection and use of pseudo-translation in determination of protein structures.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):822-7.
1998: G Schnappauf; William N Lipscomb; Gerhard H Braus
Separation of inhibition and activation of the allosteric yeast chorismate mutase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2868-73.
1997: Norbert Sträter; G Schnappauf; Gerhard H Braus; William N Lipscomb
Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures.
Structure (London, England : 1993) 1997;5(11):1437-52.
1997: Michael Karpusas; M Nolte; C B Benton; W Meier; William N Lipscomb; Susan Goelz
The crystal structure of human interferon beta at 2.2-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11813-8.
1997: G Schnappauf; Norbert Sträter; William N Lipscomb; Gerhard H Braus
A glutamate residue in the catalytic center of the yeast chorismate mutase restricts enzyme activity to acidic conditions.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8491-6.
1996: N Strater; K Hakansson; G Schnappauf; Gerhard H Braus; William N Lipscomb
Crystal structure of the T state of allosteric yeast chorismate mutase and comparison with the R state.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3330-4.
1996: R Zhang; V Villeret; William N Lipscomb; Herbert J Fromm
Kinetics and mechanisms of activation and inhibition of porcine liver fructose-1,6-bisphosphatase by monovalent cations.
Biochemistry 1996;35(9):3038-43.
1995: Norbert Sträter; William N Lipscomb
Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography.
Biochemistry 1995;34(45):14792-800.
1995: Y Xue; William N Lipscomb
Location of the active site of allosteric chorismate mutase from Saccharomyces cerevisiae, and comments on the catalytic and regulatory mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10595-8.
1995: V Villeret; S Huang; Herbert J Fromm; William N Lipscomb
Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8916-20.
1995: Norbert Sträter; William N Lipscomb
Transition state analogue L-leucinephosphonic acid bound to bovine lens leucine aminopeptidase: X-ray structure at 1.65 A resolution in a new crystal form.
Biochemistry 1995;34(28):9200-10.
1995: K M Reinisch; L Chen; G L Verdine; William N Lipscomb
The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.
Cell 1995;82(1):143-53.
1995: V Villeret; S Huang; Y Zhang; William N Lipscomb
Structural aspects of the allosteric inhibition of fructose-1,6-bisphosphatase by AMP: the binding of both the substrate analogue 2,5-anhydro-D-glucitol 1,6-bisphosphate and catalytic metal ions monitored by X-ray crystallography.
Biochemistry 1995;34(13):4307-15.
1995: V Villeret; S Huang; Y Zhang; Y Xue; William N Lipscomb
Crystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 A resolution.
Biochemistry 1995;34(13):4299-306.
1994: Y Xue; S Huang; J Y Liang; Y Zhang; William N Lipscomb
Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 2,6-bisphosphate, AMP, and Zn2+ at 2.0-A resolution: aspects of synergism between inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12482-6.
1994: Y Zhang; J Y Liang; S Huang; William N Lipscomb
Toward a mechanism for the allosteric transition of pig kidney fructose-1,6-bisphosphatase.
Journal of molecular biology 1994;244(5):609-24.
1994: Y Xue; William N Lipscomb; R Graf; G Schnappauf; Gerhard H Braus
The crystal structure of allosteric chorismate mutase at 2.2-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10814-8.
1994: Y Xue; William N Lipscomb
The crystallization and preliminary X-ray analysis of allosteric chorismate mutase.
Journal of molecular biology 1994;241(2):273-4.
1994: YuhMin Chook; J V Gray; Hengming Ke; William N Lipscomb
The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction.
Journal of molecular biology 1994;240(5):476-500.
1994: K M Reinisch; L Chen; G L Verdine; William N Lipscomb
Crystallization and preliminary crystallographic analysis of a DNA (cytosine-5)-methyltransferase from Haemophilus aegyptius bound covalently to DNA.
Journal of molecular biology 1994;238(4):626-9.
1994: William N Lipscomb
Aspartate transcarbamylase from Escherichia coli: activity and regulation.
Advances in enzymology and related areas of molecular biology 1994;68():67-151.
1994: H Kim; William N Lipscomb
Structure and mechanism of bovine lens leucine aminopeptidase.
Advances in enzymology and related areas of molecular biology 1994;68():153-213.
1993: YuhMin Chook; Hengming Ke; William N Lipscomb
Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8600-3.
1993: H Kim; William N Lipscomb
X-ray crystallographic determination of the structure of bovine lens leucine aminopeptidase complexed with amastatin: formulation of a catalytic mechanism featuring a gem-diolate transition state.
Biochemistry 1993;32(33):8465-78.
1993: H Kim; William N Lipscomb
Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by x-ray crystallography.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5006-10.
1993: H Kim; S K Burley; William N Lipscomb
Re-refinement of the X-ray crystal structure of bovine lens leucine aminopeptidase complexed with bestatin.
Journal of molecular biology 1993;230(3):722-4.
1993: J Y Liang; Y Zhang; S Huang; William N Lipscomb
Allosteric transition of fructose-1,6-bisphosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2132-6.
1993: Y Zhang; J Y Liang; S Huang; Hengming Ke; William N Lipscomb
Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry 1993;32(7):1844-57.
1993: Y Zhang; J Y Liang; William N Lipscomb
Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase.
Biochemical and biophysical research communications 1993;190(3):1080-3.
1993: R P Kosman; James Eric Gouaux; William N Lipscomb
Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins 1993;15(2):147-76.
1992: J W Stebbins; D E Robertson; Mary F Roberts; R C Stevens; William N Lipscomb; Evan R Kantrowitz
Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study.
Protein science : a publication of the Protein Society 1992;1(11):1435-46.
1992: R C Stevens; William N Lipscomb
A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5281-5.
1992: J Y Liang; S Huang; Y Zhang; Hengming Ke; William N Lipscomb
Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2404-8.
1992: S K Burley; P R David; R M Sweet; A Taylor; William N Lipscomb
Structure determination and refinement of bovine lens leucine aminopeptidase and its complex with bestatin.
Journal of molecular biology 1992;224(1):113-40.
1991: H Kim; William N Lipscomb
Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography.
Biochemistry 1991;30(33):8171-80.
1991: S K Burley; P R David; William N Lipscomb
Leucine aminopeptidase: bestatin inhibition and a model for enzyme-catalyzed peptide hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):6916-20.
1991: R C Stevens; K M Reinisch; William N Lipscomb
Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6087-91.
1991: Hengming Ke; J Y Liang; Y P Zhang; William N Lipscomb
Conformational transition of fructose-1,6-bisphosphatase: structure comparison between the AMP complex (T form) and the fructose 6-phosphate complex (R form).
Biochemistry 1991;30(18):4412-20.
1991: Hengming Ke; Y P Zhang; J Y Liang; William N Lipscomb
Crystal structure of the neutral form of fructose-1,6-bisphosphatase complexed with the product fructose 6-phosphate at 2.1-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):2989-93.
1991: R C Stevens; YuhMin Chook; C Y Cho; William N Lipscomb; Evan R Kantrowitz
Escherichia coli aspartate carbamoyltransferase: the probing of crystal structure analysis via site-specific mutagenesis.
Protein engineering 1991;4(4):391-408.
1990: R C Stevens; William N Lipscomb
Allosteric control of quaternary states in E. coli aspartate transcarbamylase.
Biochemical and biophysical research communications 1990;171(3):1312-8.
1990: S K Burley; P R David; A Taylor; William N Lipscomb
Molecular structure of leucine aminopeptidase at 2.7-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6878-82.
1990: James Eric Gouaux; R C Stevens; William N Lipscomb
Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry 1990;29(33):7702-15.
1990: R C Stevens; James Eric Gouaux; William N Lipscomb
Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry 1990;29(33):7691-701.
1990: Hengming Ke; Y P Zhang; William N Lipscomb
Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5243-7.
1990: H Kim; William N Lipscomb
Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes.
Biochemistry 1990;29(23):5546-55.
1990: J Y Liang; William N Lipscomb
Binding of substrate CO2 to the active site of human carbonic anhydrase II: a molecular dynamics study.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3675-9.
1990: Hengming Ke; C M Thorpe; B a Seaton; William N Lipscomb; F Marcus
Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 A resolution.
Journal of molecular biology 1990;212(3):513-39.
1990: Evan R Kantrowitz; William N Lipscomb
Escherichia coli aspartate transcarbamoylase: the molecular basis for a concerted allosteric transition.
Trends in biochemical sciences 1990;15(2):53-9.
1990: James Eric Gouaux; William N Lipscomb
Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry 1990;29(2):389-402.
1989: Gil Shoham; S K Burley; William N Lipscomb
Structure of cyclo(-L-prolylglycyl-)2 trihydrate.
Acta crystallographica. Section C, Crystal structure communications 1989;45 ( Pt 12)():1944-8.
1989: J Liang; William N Lipscomb
Binding of sulfonamide and acetamide to the active-site Zn2+ in carbonic anhydrase: a theoretical study.
Biochemistry 1989;28(25):9724-33.
1989: James Eric Gouaux; R C Stevens; Hengming Ke; William N Lipscomb
Crystal structure of the Glu-239----Gln mutant of aspartate carbamoyltransferase at 3.1-A resolution: an intermediate quaternary structure.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8212-6.
1989: David W Christianson; S Mangani; Gil Shoham; William N Lipscomb
Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A.
The Journal of biological chemistry 1989;264(22):12849-53.
1989: Hengming Ke; C M Thorpe; B A Seaton; F Marcus; William N Lipscomb
Molecular structure of fructose-1,6-bisphosphatase at 2.8-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(5):1475-9.
1989: James Eric Gouaux; William N Lipscomb; S A Middleton; Evan R Kantrowitz
Structure of a single amino acid mutant of aspartate carbamoyltransferase at 2.5-A resolution: implications for the cooperative mechanism.
Biochemistry 1989;28(4):1798-803.
1989: James Eric Gouaux; William N Lipscomb
Structural transitions in crystals of native aspartate carbamoyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):845-8.
1988: Hengming Ke; William N Lipscomb; Y J Cho; Richard B Honzatko
Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms.
Journal of molecular biology 1988;204(3):725-47.
1988: J Y Liang; William N Lipscomb
Hydration of CO2 by carbonic anhydrase: intramolecular proton transfer between Zn2+-bound H2O and histidine 64 in human carbonic anhydrase II.
Biochemistry 1988;27(23):8676-82.
1988: E R Kantrowitz; William N Lipscomb
Escherichia coli aspartate transcarbamylase: the relation between structure and function.
Science (New York, N.Y.) 1988;241(4866):669-74.
1988: James Eric Gouaux; William N Lipscomb
Three-dimensional structure of carbamoyl phosphate and succinate bound to aspartate carbamoyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4205-8.
1987: J Y Liang; William N Lipscomb
Hydration of carbon dioxide by carbonic anhydrase: internal proton transfer of Zn2+-bound HCO3-.
Biochemistry 1987;26(17):5293-301.
1987: K H Kim; Z X Pan; Richard B Honzatko; Hengming Ke; William N Lipscomb
Structural asymmetry in the CTP-liganded form of aspartate carbamoyltransferase from Escherichia coli.
Journal of molecular biology 1987;196(4):853-75.
1987: D W Christianson; P R David; William N Lipscomb
Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(6):1512-5.
1987: James Eric Gouaux; K L Krause; William N Lipscomb
The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase: a molecular modelling study.
Biochemical and biophysical research communications 1987;142(3):893-7.
1987: K L Krause; Karl Volz; William N Lipscomb
2.5 A structure of aspartate carbamoyltransferase complexed with the bisubstrate analog N-(phosphonacetyl)-L-aspartate.
Journal of molecular biology 1987;193(3):527-53.
1986: D W Christianson; William N Lipscomb
X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(20):7568-72.
1986: Karl Volz; K L Krause; William N Lipscomb
The binding of N-(phosphonacetyl)-L-aspartate to aspartate carbamoyltransferase of Escherichia coli.
Biochemical and biophysical research communications 1986;136(2):822-6.
1985: D W Christianson; William N Lipscomb
Binding of a possible transition state analogue to the active site of carboxypeptidase A.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(20):6840-4.
1985: L C Kuo; W Herzberg; William N Lipscomb
Substrate specificity and protonation state of ornithine transcarbamoylase as determined by pH studies.
Biochemistry 1985;24(18):4754-61.
1985: J Foote; A M Lauritzen; William N Lipscomb
Substrate specificity of aspartate transcarbamylase. Interaction of the enzyme with analogs of aspartate and succinate.
The Journal of biological chemistry 1985;260(17):9624-9.
1985: K L Krause; Karl Volz; William N Lipscomb
Structure at 2.9-A resolution of aspartate carbamoyltransferase complexed with the bisubstrate analogue N-(phosphonacetyl)-L-aspartate.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(6):1643-7.
1984: A Taylor; Karl Volz; William N Lipscomb; L J Takemoto
Leucine aminopeptidase from bovine lens and hog kidney. Comparison using immunological techniques, electron microscopy, and X-ray diffraction.
The Journal of biological chemistry 1984;259(23):14757-61.
1984: G Shoham; D C Rees; William N Lipscomb
Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7767-71.
1984: Hengming Ke; Richard B Honzatko; William N Lipscomb
Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4037-40.
1983: D C Rees; William N Lipscomb
Crystallographic studies on apocarboxypeptidase A and the complex with glycyl-L-tyrosine.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(23):7151-4.
1983: D C Rees; M Lewis; William N Lipscomb
Refined crystal structure of carboxypeptidase A at 1.54 A resolution.
Journal of molecular biology 1983;168(2):367-87.
1983: T Wieland; C Götzendörfer; J Dabrowski; William N Lipscomb; G Shoham
Unexpected similarity of the structures of the weakly toxic amanitin (S)-sulfoxide and the highly toxic (R)-sulfoxide and sulfone as revealed by proton nuclear magnetic resonance and X-ray analysis.
Biochemistry 1983;22(5):1264-71.
1983: William N Lipscomb
Structure and catalysis of enzymes.
Annual review of biochemistry 1983;52():17-34.
1982: R B Honzatko; William N Lipscomb
Interactions of metal-nucleotide complexes with aspartate carbamoyltransferase in the crystalline state.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(23):7171-4.
1982: R B Altman; Jane E Ladner; William N Lipscomb
Quaternary structural changes in aspartate carbamoyltransferase of Escherichia coli at pH 8.3 and pH 5.8.
Biochemical and biophysical research communications 1982;108(2):592-5.
1982: D C Rees; William N Lipscomb
Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution.
Journal of molecular biology 1982;160(3):475-98.
1982: Richard B Honzatko; J L Crawford; H L Monaco; Jane E Ladner; B F Ewards; David R Evans; S G Warren; D C Wiley; R C Ladner; William N Lipscomb
Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli.
Journal of molecular biology 1982;160(2):219-63.
1982: R B Honzatko; William N Lipscomb
Interactions of phosphate ligands with Escherichia coli aspartate carbamoyltransferase in the crystalline state.
Journal of molecular biology 1982;160(2):265-86.
1982: Jane E Ladner; J P Kitchell; Richard B Honzatko; Hengming Ke; Karl Volz; A J Kalb; R C Ladner; William N Lipscomb
Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(10):3125-8.
1982: L C Kuo; William N Lipscomb; E R Kantrowitz
Zn(II)-induced cooperativity of Escherichia coli ornithine transcarbamoylase.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2250-4.
1982: A M Lauritzen; William N Lipscomb
Modification of three active site lysine residues in the catalytic subunit of aspartate transcarbamylase by D- and L-bromosuccinate.
The Journal of biological chemistry 1982;257(3):1312-9.
1981: J Foote; William N Lipscomb
Kinetics of aspartate transcarbamylase from Escherichia coli for the reverse direction of reaction.
The Journal of biological chemistry 1981;256(22):11428-33.
1981: D C Rees; William N Lipscomb
Binding of ligands to the active site of carboxypeptidase A.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5455-9.
1981: D C Rees; M Lewis; R B Honzatko; William N Lipscomb; K D Hardman
Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(6):3408-12.
1981: R B Honzatko; A M Lauritzen; William N Lipscomb
Metal cation influence on activity and regulation of aspartate carbamoyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):898-902.
1981: William N Lipscomb
A survey of x-ray diffraction studies of enzyme-other molecule interactions as possible models for receptor sites.
Annals of the New York Academy of Sciences 1981;367():326-39.
1980: A M Lauritzen; William N Lipscomb
Effect of pH on local and gross conformational changes in aspartate transcarbamylase.
Biochemical and biophysical research communications 1980;95(4):1425-30.
1980: D C Rees; William N Lipscomb
Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(8):4633-7.
1980: William N Lipscomb
Carboxypeptidase A mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):3875-8.
1980: D C Rees; R B Honzatko; William N Lipscomb
Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3288-91.
1980: A M Lauritzen; Scott M Landfear; William N Lipscomb
Inactivation of the catalytic subunit of aspartate transcarbamylase by nitration with tetranitromethane.
The Journal of biological chemistry 1980;255(2):602-7.
1980: D C Rees; William N Lipscomb
Structure of potato inhibitor complex of carboxypeptidase A at 5.5-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(1):277-80.
1979: D A Dixon; D L Lindner; B Branchaud; William N Lipscomb
Conformations and electronic structures of oxidized and reduced isoalloxazine.
Biochemistry 1979;18(26):5770-5.
1979: M H Baron; William N Lipscomb; David R Evans
The location and local environment of the active sites of aspartate transcarbamylase.
The Journal of biological chemistry 1979;254(21):10686-93.
1979: David R Evans; William N Lipscomb
The modification of the catalytic chain sulfhydryl group of aspartate transcarbamylase with mercurinitrophenols.
The Journal of biological chemistry 1979;254(21):10679-85.
1979: R B Honzatko; H L Monaco; William N Lipscomb
A 3.0-A resolution study of nucleotide complexes with aspartate carbamoyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):5105-9.
1978: H L Monaco; J L Crawford; William N Lipscomb
Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(11):5276-80.
1978: E C Kostansek; William N Lipscomb; R R Yocum; W E Thiessen
Conformation of the mushroom toxin beta-amanitin in the crystalline state.
Biochemistry 1978;17(18):3790-5.
1978: S C Pastra-Landis; David R Evans; William N Lipscomb
The effect of pH on the cooperative behavior of aspartate transcarbamylase from Escherichia coli.
The Journal of biological chemistry 1978;253(13):4624-30.
1978: Scott M Landfear; William N Lipscomb; David R Evans
Functional modifications of aspartate transcarbamylase induced by nitration with tetranitromethane.
The Journal of biological chemistry 1978;253(11):3988-96.
1978: Scott M Landfear; David R Evans; William N Lipscomb
Elimination of cooperativity in aspartate transcarbamylase by nitration of a single tyrosine residue.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(6):2654-8.
1977: Y Y Chiu; L D Brown; William N Lipscomb
Crystal and molecular structure of complex between cyclo(L-prolylglycyl)4 and RbSCN.
Journal of the American Chemical Society 1977;99(14):4799-4803.
1977: S Scheiner; William N Lipscomb
Molecular orbital studies of enzyme activity. 4. Hydrolysis of peptides by carboxypeptidase A.
Journal of the American Chemical Society 1977;99(10):3466-72.
1977: E R Kantrowitz; William N Lipscomb
Functionally important arginine residues of aspartate transcarbamylase.
The Journal of biological chemistry 1977;252(9):2873-80.
1977: E C Kostansek; William N Lipscomb; R R Yocum; W E Thiessen
The crystal structure of the mushroom toxin beta-amanitin.
Journal of the American Chemical Society 1977;99(4):1273-4.
1977: E R Kantrowitz; L B Jacobsberg; Scott M Landfear; William N Lipscomb
Interaction of tetraiodofluorescein with a modified form of aspartate transcarbamylase.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(1):111-4.
1977: William N Lipscomb
Intramolecular interactions, enzyme activity and models.
Ciba Foundation symposium 1977;(60):1-22.
1976: D A Dixon; William N Lipscomb
Electronic structure and bonding of the amino acids containing first row atoms.
The Journal of biological chemistry 1976;251(19):5992-6000.
1976: S Scheiner; William N Lipscomb; D A Kleier
Molecular orbital studies of enzyme activity. 2. Nucleophilic attack on carbonyl systems with comments on orbital steering.
Journal of the American Chemical Society 1976;98(16):4770-7.
1976: E R Kantrowitz; William N Lipscomb
An essential residue at the active site of aspartate transcarbamylase.
The Journal of biological chemistry 1976;251(9):2688-95.
1976: S Scheiner; William N Lipscomb
Molecular orbital studies of enzyme activity: catalytic mechanism of serine proteinases.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):432-6.
1975: L B Jacobsverg; E R Kantrowitz; William N Lipscomb
Interaction of tetraiodofluorescein with aspartate transcarbamylase and its isolated catalytic and regulatory subunits.
The Journal of biological chemistry 1975;250(24):9238-49.
1975: S Scheiner; D A Kleier; William N Lipscomb
Molecular orbital studies of enzyme activity: I: Charge relay system and tetrahedral intermediate in acylation of serine proteinases.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(7):2606-10.
1975: David R Evans; S C Pastra-Landis; William N Lipscomb
Isolation and properties of a species produced by the partial dissociation of aspartate transcarbamylase from Escherichia coli.
The Journal of biological chemistry 1975;250(10):3571-83.
1975: Y Y Chiu; William N Lipscomb
Molecular and crystal structure of streptonigrin.
Journal of the American Chemical Society 1975;97(9):2525-30.
1974: Brian F P Edwards; David R Evans; S G Warren; H L Monaco; Scott M Landfear; G Eisele; J L Crawford; D C Wiley; William N Lipscomb
Complex of aspartate carbamoyltransferase from Escherichia coli with its allosteric inhibitor, cytidine triphosphate: electron density at 5.9-angstroms resolution.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(11):4437-41.
1974: H S Wong; E I Tolpin; William N Lipscomb
Boron hydride derivatives for neutron capture therapy. Antibody approach.
Journal of medicinal chemistry 1974;17(8):785-91.
1974: E I Tolpin; H S Wong; William N Lipscomb
Binding studies of boron hydride derivatives to proteins for neutron capture therapy.
Journal of medicinal chemistry 1974;17(8):792-6.
1974: D A Kleier; J H Hall; T A Halgren; William N Lipscomb
Localized molecular orbital description of nitrogen lone pairs.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(6):2265-7.
1974: David R Evans; S C Pastra-Landis; William N Lipscomb
An intermediate complex in the dissociation of aspartate transcarbamylase.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(4):1351-5.
1974: William N Lipscomb; David R Evans; Brian F P Edwards; S G Warren; S Pastra-Landis; D C Wiley
Three-dimensional structures at 5.5 A resolution and regulatory processes in aspartate transcarbamylase from E. coli.
Journal of supramolecular structure 1974;2(2-4):82-98.
1973: L B Jacobsberg; E R Kantrowitz; C H McMurray; William N Lipscomb
The interaction of tetraiodofluorescein with aspartate transcarbamylase.
Biochemical and biophysical research communications 1973;55(4):1255-61.
1973: William N Lipscomb
Enzymatic activities of carobxypeptidase A's in solution and in crystals.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(12):3797-801.
1973: S G Warren; Brian F P Edwards; David R Evans; D C Wiley; William N Lipscomb
Aspartate transcarbamoylase from Escherichia coli: electron density at 5.5 A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(4):1117-21.
1973: David R Evans; S G Warren; Brian F P Edwards; C H McMurray; P H Bethge; D C Wiley; William N Lipscomb
Aqueous central cavity in aspartate transcarbamylase from Escherichia coli.
Science (New York, N.Y.) 1973;179(4074):683-5.
1973: J L Crawford; William N Lipscomb; C G Schellman
The reverse turn as a polypeptide conformation in globular proteins.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(2):538-42.
1972: David R Evans; C H McMurray; William N Lipscomb
The thiol group in the catalytic chains of aspartate transcarbamoylase.
Proceedings of the National Academy of Sciences of the United States of America 1972;69(12):3638-42.
1972: F A Quiocho; C H McMurray; William N Lipscomb
Similarities between the conformation of arsanilazotyrosine 248 of carboxypeptidase A in the crystalline state and in solution.
Proceedings of the National Academy of Sciences of the United States of America 1972;69(10):2850-4.
1972: T A Halgren; William N Lipscomb
Approximations to self-consistent field molecular wavefunctions.
Proceedings of the National Academy of Sciences of the United States of America 1972;69(3):652-6.
1972: F A Quiocho; P H Bethge; William N Lipscomb; J F Studebaker; R D Brown; S H Koenig
X-ray diffraction and nuclear magnetic resonance dispersion studies on derivatives of carboxypeptidase A.
Cold Spring Harbor symposia on quantitative biology 1972;36():561-7.
1972: D C Wiley; David R Evans; S G Warren; C H McMurray; Brian F P Edwards; W A Franks; William N Lipscomb
The 5.5 Angstrom resolution structure of the regulatory enzyme, asparate transcarbamylase.
Cold Spring Harbor symposia on quantitative biology 1972;36():285-90.
1971: F A Quiocho; G N Reeke; J W Becker; William N Lipscomb; Gerald M Edelman
Structure of soncanavalin A at 4 A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(8):1853-7.
1971: F A Quiocho; William N Lipscomb
Carboxypeptidase A: a protein and an enzyme.
Advances in protein chemistry 1971;25():1-78.
1970: William N Lipscomb; G N Reeke; J A Hartsuck; F A Quiocho; P H Bethge
The structure of carboxypeptidase A. 8. Atomic interpretation at 0.2 nm resolution, a new study of the complex of glycyl-L-tyrosine with CPA, and mechanistic deductions.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1970;257(813):177-214.
1969: D B Boyd; William N Lipscomb
Electronic structures for energy-rich phosphates.
Journal of theoretical biology 1969;25(3):403-20.
1969: William N Lipscomb; J A Hartsuck; F A Quiocho; G N Reeke
The structure of carboxypeptidase A. IX. The x-ray diffraction results in the light of the chemical sequence.
Proceedings of the National Academy of Sciences of the United States of America 1969;64(1):28-35.
1968: D C Wiley; William N Lipscomb
Crystallographic determination of symmetry of aspartate transcarbamylase.
Nature 1968;218(5147):1119-21.
1968: William N Lipscomb; J A Hartsuck; G N Reeke; F A Quiocho; P H Bethge; M L Ludwig; T A Steitz; H Muirhead; J C Coppola
The structure of carboxypeptidase A. VII. The 2.0-angstrom resolution studies of the enzyme and of its complex with glycyltyrosine, and mechanistic deductions.
Brookhaven symposia in biology 1968;21(1):24-90.
1967: G N Reeke; J A Hartsuck; M L Ludwig; F A Quiocho; T A Steitz; William N Lipscomb
The structure of carboxypeptidase a, vi. Some results at 2.0-a resolution, and the complex with glycyl-tyrosine at 2.8-a resolution.
Proceedings of the National Academy of Sciences of the United States of America 1967;58(6):2220-6.
1967: T A Steitz; D C Wiley; William N Lipscomb
The structure of aspartate transcarbamylase, I. A molecular twofold axis in the complex with cytidine triphosphate.
Proceedings of the National Academy of Sciences of the United States of America 1967;58(5):1859-61.
1967: T A Steitz; M L Ludwig; F A Quiocho; William N Lipscomb
The structure of carboxypepidase A. V. Studies of enzyme-substrate and enzyme-inhibitor complexes at 6 A resolution.
The Journal of biological chemistry 1967;242(20):4662-8.
1966: J A Potenza; William N Lipscomb
MOLECULAR STRUCTURE OF m-B(10)Cl(10)C(2)H(2).
Proceedings of the National Academy of Sciences of the United States of America 1966;56(6):1917-9.
1966: J W Moncrief; William N Lipscomb
Structure of leurocristine methiodide dihydrate by anomalous scattering methods; relation to leurocristine (vincristine) and vincaleukoblastine (vinblastine).
Acta crystallographica 1966;21(3):322-31.
1965: J W Moncrief; William N Lipscomb
Structures of leurocristine (vincristine) and vincaleukoblastine. X-ray analysis of leurocristine methiodide.
Journal of the American Chemical Society 1965;87(21):4963-4.
1965: M D Newton; F P Boer; W E Palke; William N Lipscomb
NONEMPIRICAL MOLECULAR ORBITAL THEORY FROM MOLECULAR HARTREE-FOCK THEORY.
Proceedings of the National Academy of Sciences of the United States of America 1965;53(5):1089-91.
1965: J A Hartsuck; M L Ludwig; H Muirhead; T A Steitz; William N Lipscomb
CARBOXYPEPTIDASE A, II. THE THREE-DIMENSIONAL ELECTRON DENSITY MAP AT 6 A RESOLUTION.
Proceedings of the National Academy of Sciences of the United States of America 1965;53(2):396-403.
1964: F P Boer; M D Newton; William N Lipscomb
EXTENDED HUCKEL THEORY AND MOLECULAR HARTREE-FOCK SCF THEORY.
Proceedings of the National Academy of Sciences of the United States of America 1964;52(4):890-3.
1963: M L LUDWIG; I C PAUL; G S PAWLEY; William N Lipscomb
THE STRUCTURE OF CARBOXYPEPTIDASE A, I. A TWO-DIMENSIONAL SUPERPOSITION FUNCTION.
Proceedings of the National Academy of Sciences of the United States of America 1963;50():282-5.
1962: P G Simpson; William N Lipscomb
MOLECULAR STRUCTURE OF B(18)H(22).
Proceedings of the National Academy of Sciences of the United States of America 1962;48(9):1490-1.
1962: W E Streib; William N Lipscomb
GROWTH, ORIENTATION, AND X-RAY DIFFRACTION OF SINGLE CRYSTALS NEAR LIQUID HELIUM TEMPERATURES.
Proceedings of the National Academy of Sciences of the United States of America 1962;48(6):911-3.
1962: A Kaczmarczyk; R D Dobrott; William N Lipscomb
REACTIONS OF B(10)H(10) ION.
Proceedings of the National Academy of Sciences of the United States of America 1962;48(5):729-33.
1962: R N Grimes; William N Lipscomb
DECABORANE (16): ITS REARRANGEMENT TO DECABORANE (14) AND CLEAVAGE.
Proceedings of the National Academy of Sciences of the United States of America 1962;48(4):496-9.
1961: William N Lipscomb; A Kaczmarczyk
INTERACTIONS OF BORANES AND THEIR IONS WITH PARAMAGNETIC S-STATE IONS.
Proceedings of the National Academy of Sciences of the United States of America 1961;47(11):1796-7.
1961: William N Lipscomb
EXTENSIONS OF THE VALENCE THEORY OF BORON COMPOUNDS.
Proceedings of the National Academy of Sciences of the United States of America 1961;47(11):1791-5.
1961: R Grimes; F E Wang; R Lewin; William N Lipscomb
A NEW TYPE OF BORON HYDRIDE, B(10)H(16).
Proceedings of the National Academy of Sciences of the United States of America 1961;47(7):996-9.