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Kenneth Lipson

Research Profile

Chemicals & Drugs

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Phosphorylation

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Xenograft Model Antitumor Assays

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Publications

TOP 3
Minglun Li; Amir Abdollahi; Hermann-Josef Gröne; Kenneth E Lipson; Claus Belka; Peter E Huber
Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model.
Carmen Timke; Heike Zieher; Alexandra Roth; Kai Hauser; Kenneth E Lipson; Klaus J Weber; Jürgen Debus; Amir Abdollahi; Peter E Huber
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
Stefanie Milker-Zabel; Angelika Zabel-du Bois; Gholamreza Ranai; Thuy Trinh; Andreas Unterberg; Jürgen Debus; Kenneth E Lipson; Amir Abdollahi; Peter E Huber
SU11657 enhances radiosensitivity of human meningioma cells.

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All Publications

2009: Minglun Li; Amir Abdollahi; Hermann-Josef Gröne; Kenneth E Lipson; Claus Belka; Peter E Huber
Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model.
Radiation oncology (London, England) 2009;4():66.
2008: Carmen Timke; Heike Zieher; Alexandra Roth; Kai Hauser; Kenneth E Lipson; Klaus J Weber; Jürgen Debus; Amir Abdollahi; Peter E Huber
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2210-9.
2008: Stefanie Milker-Zabel; Angelika Zabel-du Bois; Gholamreza Ranai; Thuy Trinh; Andreas Unterberg; Jürgen Debus; Kenneth E Lipson; Amir Abdollahi; Peter E Huber
SU11657 enhances radiosensitivity of human meningioma cells.
International journal of radiation oncology, biology, physics 2008;70(4):1213-8.
2006: Susanne Oertel; Robert Krempien; Katja Lindel; Angelika Zabel; Stefanie Milker-Zabel; Marc Bischof; Kenneth E Lipson; Peter Peschke; Jürgen Debus; Amir Abdollahi; Peter E Huber
Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec).
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2006;182(7):400-7.
2006: Asim N Cheema; Tony Hong; Nafiseh Nili; Amit Segev; John G Moffat; Kenneth E Lipson; Anthony R Howlett; David W Holdsworth; Michael J Cole; Beiping Qiang; Frank D Kolodgie; Renu Virmani; Duncan J Stewart; Bradley Strauss
Adventitial microvessel formation after coronary stenting and the effects of SU11218, a tyrosine kinase inhibitor.
Journal of the American College of Cardiology 2006;47(5):1067-75.
2006: Minglun Li; Gong Ping; Christian Plathow; Thuy Trinh; Kenneth E Lipson; Kai Hauser; Robert Krempien; Jürgen Debus; Amir Abdollahi; Peter E Huber
Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifies radiation response in fibroblasts and endothelial cells.
BMC cancer 2006;6():79.
2005: Amir Abdollahi; David W Griggs; Heike Zieher; Alexandra Roth; Kenneth E Lipson; Rainer Saffrich; Hermann-Josef Gröne; Dennis E Hallahan; Ralph A Reisfeld; Jürgen Debus; Andreas G Niethammer; Peter E Huber
Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6270-9.
2005: Peter E Huber; Marc Bischof; Jürgen W Jenne; Sabine Heiland; Peter Peschke; Rainer Saffrich; Hermann-Josef Gröne; Jürgen Debus; Kenneth E Lipson; Amir Abdollahi
Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy.
Cancer research 2005;65(9):3643-55.
2005: Amir Abdollahi; Minglun Li; Gong Ping; Christian Plathow; Sophie Domhan; Fabian Kiessling; Leslie B Lee; Gerald McMahon; Hermann-Josef Gröne; Kenneth E Lipson; Peter E Huber
Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis.
The Journal of experimental medicine 2005;201(6):925-35.
2004: Julie Litz; G Sakuntala Warshamana-Greene; Geoffrey Sulanke; Kenneth E Lipson; Geoffrey W Krystal
The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression.
Lung cancer (Amsterdam, Netherlands) 2004;46(3):283-91.
2004: Marc Bischof; Amir Abdollahi; Ping Gong; Clemens Stoffregen; Kenneth E Lipson; Jürgen Debus; Klaus-Josef Weber; Peter E Huber
Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells.
International journal of radiation oncology, biology, physics 2004;60(4):1220-32.
2004: Sylvie Berthou; Daniel M Aebersold; Laura S Schmidt; Deborah Stroka; Christine Heigl; Bruno Streit; Denise Stalder; Günther Gruber; Congxin Liang; Anthony R Howlett; Daniel Candinas; Richard H Greiner; Kenneth E Lipson; Yitzhak Zimmer
The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.
Oncogene 2004;23(31):5387-93.
2003: Amir Abdollahi; Kenneth E Lipson; Axel Sckell; Heike Zieher; Frank Michael Klenke; Daniel Poerschke; Alexandra Roth; Xiaohong Han; Martin Krix; Marc Bischof; Philip Hahnfeldt; Hermann-Josef Grone; Jürgen Debus; Lynn Hlatky; Peter E Huber
Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects.
Cancer research 2003;63(24):8890-8.
2003: Xueyan Wang; Phuong Le; Congxin Liang; Julie Chan; David Kiewlich; Todd Miller; Dave Harris; Li Sun; Audie Rice; Stefan Vasile; Robert Blake; Anthony R Howlett; Neela Patel; Gerald McMahon; Kenneth E Lipson
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
Molecular cancer therapeutics 2003;2(11):1085-92.
2003: James G Christensen; Randall E Schreck; Jon Burrows; Poonam Kuruganti; Emily Chan; Phuong Le; Jeffrey Chen; Xueyan Wang; Lany Ruslim; Robert Blake; Kenneth E Lipson; John Ramphal; Steven Do; Jingrong J Cui; Julie M Cherrington; Dirk B Mendel
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
Cancer research 2003;63(21):7345-55.
2003: Michel De Bandt; Meriem H Ben Mahdi; Véronique Ollivier; Maggy Grossin; Magali Dupuis; Murielle Gaudry; Peter Bohlen; Kenneth E Lipson; Audie Rice; Yan Wu; Marie-Anne Gougerot-Pocidalo; Catherine Pasquier
Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4853-9.
2003: Amir Abdollahi; Kenneth E Lipson; Xiaohong Han; Robert Krempien; Thuy Trinh; Klaus-Josef Weber; Philip Hahnfeldt; Lynn Hlatky; Jürgen Debus; Anthony R Howlett; Peter E Huber
SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.
Cancer research 2003;63(13):3755-63.
2003: Jean-Christophe Tille; Xueyan Wang; Kenneth E Lipson; Gerald McMahon; Napoleone Ferrara; Zhenping Zhu; Daniel J Hicklin; Jonathan P Sleeman; Ulf Eriksson; Kari Alitalo; Michael S Pepper
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro.
Experimental cell research 2003;285(2):286-98.
2003: Eva L Lund; Minna W B Olsen; Kenneth E Lipson; Gerald McMahon; Anthony R Howlett; Paul E.G. Kristjansen
Improved effect of an antiangiogenic tyrosine kinase inhibitor (SU5416) by combinations with fractionated radiotherapy or low molecular weight heparin.
Neoplasia (New York, N.Y.) 2003;5(2):155-60.
2003: Jocelyn H Wright; Xueyan Wang; Gerard Manning; Brandon J LaMere; Phuong Le; Shirley Zhu; Deepak Khatry; Peter M Flanagan; Sharon D Buckley; David B Whyte; Anthony R Howlett; James R Bischoff; Kenneth E Lipson; Bahija Jallal
The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.
Molecular and cellular biology 2003;23(6):2068-82.
2001: R Haddad; Kenneth E Lipson; Craig Webb
Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors.
Anticancer research 2001;21(6B):4243-52.
2001: Kyle A Furge; David Kiewlich; Phuong Le; M N Vo; M Faure; Anthony R Howlett; Kenneth E Lipson; George Vande Woude; Craig Webb
Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10722-7.
2001: M E Lane; B Yu; A Rice; Kenneth E Lipson; C Liang; L Sun; C Tang; Gerald McMahon; R G Pestell; S Wadler
A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.
Cancer research 2001;61(16):6170-7.
2001: Geoffrey W Krystal; S Honsawek; David Kiewlich; Congxin Liang; Stefan Vasile; Li Sun; Gerald McMahon; Kenneth E Lipson
Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.
Cancer research 2001;61(9):3660-8.
2001: Y Yamasaki; K Miyoshi; N Oda; M Watanabe; H Miyake; J Chan; X Wang; L Sun; C Tang; Gerald McMahon; Kenneth E Lipson
Weekly dosing with the platelet-derived growth factor receptor tyrosine kinase inhibitor SU9518 significantly inhibits arterial stenosis.
Circulation research 2001;88(6):630-6.
2000: Li Sun; N Tran; Congxin Liang; S Hubbard; F Tang; Kenneth E Lipson; Randall E Schreck; Y Zhou; Gerald McMahon; Cho Tang
Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.
Journal of medicinal chemistry 2000;43(14):2655-63.
1998: Kenneth E Lipson; L Pang; L J Huber; H Chen; J M Tsai; P Hirth; A Gazit; A Levitzki; Gerald McMahon
Inhibition of platelet-derived growth factor and epidermal growth factor receptor signaling events after treatment of cells with specific synthetic inhibitors of tyrosine kinase phosphorylation.
The Journal of pharmacology and experimental therapeutics 1998;285(2):844-52.