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Peter Barnes

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Yoshiki Kobayashi; Shin'ichiro Mikura; Christos Rossios; Dai Takagi; Hiroo Wada; Peter J Barnes; Hajime Goto; Manabu Higaki; Kazuhiro Ito
A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.
Kittipong Maneechotesuwan; Adisak Wongkajornsilp; Kanda Kasetsinsombat; Peter J Barnes
Decreased indoleamine 2,3-dioxygenase activity and IL-10/IL-17A ratio in patients with COPD.
Peter J Barnes
Development of New Drugs for COPD.

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2013: Yoshiki Kobayashi; Shin'ichiro Mikura; Christos Rossios; Dai Takagi; Hiroo Wada; Peter J Barnes; Hajime Goto; Manabu Higaki; Kazuhiro Ito
A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.
The Journal of pharmacology and experimental therapeutics 2013;345(1):76-84.
2013: Kittipong Maneechotesuwan; Adisak Wongkajornsilp; Kanda Kasetsinsombat; Peter J Barnes
Decreased indoleamine 2,3-dioxygenase activity and IL-10/IL-17A ratio in patients with COPD.
Thorax 2013;68(4):330-7.
2013: Peter J Barnes
Development of New Drugs for COPD.
Current medicinal chemistry 2013;20(12):1531-40.
2013: Peter J Barnes
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease.
The Journal of allergy and clinical immunology 2013;131(3):636-45.
2013: Stephanie M Brown; Akira Koarai; Andrew G Nicholson; Richard G Sturton; Peter J Barnes; Louise E Donnelly
A role for M2 and M3 muscarinic receptors in the contraction of rat and human small airways.
European journal of pharmacology 2013;702(1-3):109-15.
2013: Kittipong Maneechotesuwan; V Wamanuttajinda; Adisak Wongkajornsilp; K Kasetsinsombat; Peter J Barnes
Statins enhance the effects of corticosteroids on the balance between regulatory T cells and Th17 cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2013;43(2):212-22.
2013: Paolo Montuschi; Nadia Mores; Andrea Trové; Chiara Mondino; Peter J Barnes
The electronic nose in respiratory medicine.
Respiration; international review of thoracic diseases 2013;85(1):72-84.
2012: Peter J Barnes
New drugs for asthma.
Seminars in respiratory and critical care medicine 2012;33(6):685-94.
2012: Patrick Mallia; Simon D Message; Gregory Oleszkiewicz; Alberto Papi; Rosa Sotero; Luminita A Stanciu; Maria-Belen Trujillo-Torralbo; Tatiana Kebadze; Onn Min Kon; Ian M Adcock; Julia Aniscenko; Peter J Barnes; Marco Contoli; Sarah L Elkin; Joseph Footitt; Katrina Gray; Kazuhiro Ito; Annette Jepson; Malcolm Johnson; Sebastian L Johnston
Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2012;186(11):1117-24.
2012: Yoshiki Kobayashi; Nicolas Mercado; Anna Miller-Larsson; Peter J Barnes; Kazuhiro Ito
Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation.
Pulmonary pharmacology & therapeutics 2012;25(3):201-7.
2012: Masako To; Satoshi Yamamura; Kenichi Akashi; Peter J Barnes; Catherine E Charron; Kazuhiro Ito
Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7.
Chest 2012;141(5):1233-42.
2012: Louise E Donnelly; Peter J Barnes
Defective phagocytosis in airways disease.
Chest 2012;141(4):1055-62.
2012: Adam Antczak; Maciej Ciebiada; Pawel Gorski; Sergei A Kharitonov; Peter J Barnes
Inflammatory markers: exhaled nitric oxide and carbon monoxide during the ovarian cycle.
Inflammation 2012;35(2):554-9.
2012: Peter J Barnes; Andrea Bizzi; Gabriele Nicolini; Monica Spinola; Dave Singh
Do inhaled corticosteroid/long-acting beta2-agonist fixed combinations provide superior clinical benefits compared with separate inhalers? A literature reappraisal.
Allergy and asthma proceedings : the official journal of regional and state allergy societies 2012;33(2):140-4.
2012: Paolo Montuschi; Debora Paris; Valeria Raia; Peter J Barnes; Andrew Bush; Cecilia Calabrese; Giovanni Ciabattoni; Vincenzina Lucidi; Dominique Melck; Andrea Motta
NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis.
Thorax 2012;67(3):222-8.
2012: A Koarai; Andrew G Nicholson; Richard E K Russell; Suzanne L Traves; Peter J Barnes; S M Brown; K K Chana; Peter S Fenwick; Louise E Donnelly
Expression of muscarinic receptors by human macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;39(3):698-704.
2012: Omar S Usmani; Peter J Barnes
Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease.
Annals of medicine 2012;44(2):146-56.
2012: Nicolas Mercado; Omar S Usmani; Yoshiki Kobayashi; Sally Meah; Peter J Barnes; Kian Fan Chung; Amir Hakim; Kazuhiro Ito
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma.
PloS one 2012;7(7):e41582.
2012: Katsuyuki Tomita; Peter J Barnes; Gaetano Caramori; K Fan Chung; Borja Cosio; Kazuhiro Ito; Sam Lim; Timothy Oates; Hiroyuki Sano; Yuji Tohda; Ian M Adcock
STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.
Journal of inflammation (London, England) 2012;9():5.
2011: Paolo Montuschi; Peter J Barnes
New perspectives in pharmacological treatment of mild persistent asthma.
Drug discovery today 2011;16(23-24):1084-91.
2011: Nicholas Mercado; Yasuo To; Ian M Adcock; Peter J Barnes; Yoshiki Kobayashi; Kazuhiro Ito
p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma.
Molecular pharmacology 2011;80(6):1128-35.
2011: Sarah Essilfie-Quaye; Kazuhiro Ito; Misako Ito; Sergei A Kharitonov; Peter J Barnes
Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients.
Respiratory medicine 2011;105(12):1784-9.
2011: Reka Gajdocsi; Ildiko Horvath; Balazs Antus; Peter J Barnes; Andras Bikov; Sergei A Kharitonov
Assessment of reproducibility of exhaled hydrogen peroxide concentration and the effect of breathing pattern in healthy subjects.
Journal of aerosol medicine and pulmonary drug delivery 2011;24(6):271-5.
2011: Christos Rossios; Masako To; Yasuo To; Ian M Adcock; Peter J Barnes; Misako Ito; Malcolm Johnson; Kazuhiro Ito
Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells.
European journal of pharmacology 2011;670(1):244-51.
2011: Paul A Kirkham; Alberto A Papi; Mariona Pinart; Betty Shamji; Laurie Stevens; Kostas Triantaphyllopoulos; Michael Yeadon; Peter J Barnes; Gaetano Caramori; Paolo Casolari; Kian F Chung; Matt Edwards; Lucy Heinemann; Farhana Hussain; Younis Khan; Ian M Adcock
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2011;184(7):796-802.
2011: Peter J Barnes
Interview with Peter Barnes.
Future medicinal chemistry 2011;3(13):1575-9.
2011: Grant C Nicholson; Deborah Quinn; David Rodman; Andrew J Tan; Christoph Walker; John Westwick; Jens M Hohlfeld; Stipo Jurcevic; Harsha H Kariyawasam; Onn Min Kon; Norbert Krug; Peter J Barnes; Trevor T Hansel
The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge.
The Journal of allergy and clinical immunology 2011;128(4):800-807.e9.
2011: Peter J Barnes
Biochemical basis of asthma therapy.
The Journal of biological chemistry 2011;286(38):32899-905.
2011: Peter J Barnes
Pathophysiology of allergic inflammation.
Immunological reviews 2011;242(1):31-50.
2011: Masako To; Pilar M Ausin; Kazuhiro Ito; Sergei A Kharitonov; Peter J Barnes
Osteoprotegerin in sputum is a potential biomarker in COPD.
Chest 2011;140(1):76-83.
2011: Peter J Barnes
Triple inhalers for obstructive airways disease: will they be useful?
Expert review of respiratory medicine 2011;5(3):297-300.
2011: Gaetano Caramori; Ian M Adcock; Paolo Casolari; Kazuhiro Ito; Elen Jazrawi; Loukia Tsaprouni; Gino Villetti; Maurizio Civelli; Chiara Carnini; Kian Fan Chung; Peter J Barnes; Alberto Papi
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.
Thorax 2011;66(6):521-7.
2011: Carol Pridgeon; Laurence Bugeon; Louise Donnelly; Ursula Straschil; Susan J Tudhope; Peter Fenwick; Jonathan R Lamb; Peter J Barnes; Margaret J Dallman
Regulation of IL-17 in chronic inflammation in the human lung.
Clinical science (London, England : 1979) 2011;120(12):515-24.
2011: Nicolas Mercado; Yasuo To; Kazuhiro Ito; Peter J Barnes
Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ.
The Journal of pharmacology and experimental therapeutics 2011;337(2):465-70.
2011: Peter J Barnes
Glucocorticosteroids: current and future directions.
British journal of pharmacology 2011;163(1):29-43.
2011: Nicolas Mercado; Rajesh K Thimmulappa; Catherine M R Thomas; Peter S Fenwick; Kirandeep K Chana; Louise E Donnelly; Shyam Biswal; Kazuhiro Ito; Peter J Barnes
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Biochemical and biophysical research communications 2011;406(2):292-8.
2011: Gaetano Caramori; Angelo G Casalini; Paolo Casolari; Kian Fan Chung; Marco Contoli; Lisa Lasagna; Anna Padovani; Alberto Papi; Guido Rindi; Federica Tafuro; Ian M Adcock; Peter J Barnes; Giuseppina Bertorelli
Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy.
PloS one 2011;6(7):e22637.
2011: Adam Antczak; Maciej Ciebiada; Pawel Gorski; Jerzy Marczak; Wojciech Piotrowski; Peter J Barnes
Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate.
Disease markers 2011;30(5):213-20.
2011: Ian M Adcock; Gaetano Caramori; Peter J Barnes
Chronic obstructive pulmonary disease and lung cancer: new molecular insights.
Respiration; international review of thoracic diseases 2011;81(4):265-84.
2010: Peter J Barnes
Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.) 2010;330(6000):40-1.
2010: Kittipong Maneechotesuwan; Wuttichai Ekjiratrakul; Kanda Kasetsinsombat; Adisak Wongkajornsilp; Peter J Barnes
Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase.
The Journal of allergy and clinical immunology 2010;126(4):754-762.e1.
2010: Yasuo To; Kazuhiro Ito; Yasuo Kizawa; Marco Failla; Misako Ito; Tadashi Kusama; W Mark Elliott; James C Hogg; Ian M Adcock; Peter J Barnes
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2010;182(7):897-904.
2010: Tricia K Finney-Hayward; Mariana Oana Popa; Parmjit Bahra; Su Li; Christopher T Poll; Martin Gosling; Andrew G Nicholson; Richard E K Russell; Onn Min Kon; Gabor Jarai; John Westwick; Peter J Barnes; Louise E Donnelly
Expression of transient receptor potential C6 channels in human lung macrophages.
American journal of respiratory cell and molecular biology 2010;43(3):296-304.
2010: Peter J Barnes
New therapies for asthma: is there any progress?
Trends in pharmacological sciences 2010;31(7):335-43.
2010: Louise E Donnelly; S J Tudhope; P S Fenwick; Peter J Barnes
Effects of formoterol and salmeterol on cytokine release from monocyte-derived macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(1):178-86.
2010: Paul A Ford; Andrew L Durham; Richard E K Russell; Fabiana Gordon; Ian M Adcock; Peter J Barnes
Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD.
Chest 2010;137(6):1338-44.
2010: Peter J Barnes; Stuart J Pocock; Helgo Magnussen; Amir Iqbal; Benjamin Kramer; Mark Higgins; David Lawrence
Integrating indacaterol dose selection in a clinical study in COPD using an adaptive seamless design.
Pulmonary pharmacology & therapeutics 2010;23(3):165-71.
2010: Peter J Barnes
Mechanisms and resistance in glucocorticoid control of inflammation.
The Journal of steroid biochemistry and molecular biology 2010;120(2-3):76-85.
2010: A E Taylor; T K Finney-Hayward; J K Quint; C M R Thomas; S J Tudhope; Jadwiga A Wedzicha; Peter J Barnes; Louise E Donnelly
Defective macrophage phagocytosis of bacteria in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;35(5):1039-47.
2010: Paolo Montuschi; Marco Santonico; Chiara Mondino; Giorgio Pennazza; Giulia Mantini; Eugenio Martinelli; Rosamaria Capuano; Giovanni Ciabattoni; Roberto Paolesse; Corrado Di Natale; Peter J Barnes; Arnaldo D'Amico
Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma.
Chest 2010;137(4):790-6.
2010: Katia Varani; Gaetano Caramori; Fabrizio Vincenzi; Alice Tosi; Adam Barczyk; Marco Contoli; Paolo Casolari; Massimo Triggiani; Trevor Hansel; Edward Leung; Stephen Maclennan; Peter J Barnes; Kian Fan Chung; Ian Adcock; Alberto Papi; Pier Andrea Borea
Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(4):1192-204.
2010: Paolo Paredi; Michael Goldman; Almahdi Alamen; Pilar Ausin; Omar S Usmani; Neil B Pride; Peter J Barnes
Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease.
Thorax 2010;65(3):263-7.
2010: Peter J Barnes
Chronic obstructive pulmonary disease: effects beyond the lungs.
PLoS medicine 2010;7(3):e1000220.
2010: Peter J Barnes
New therapies for chronic obstructive pulmonary disease.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2010;19(5):330-8.
2010: Peter J Barnes
Inhaled corticosteroids in COPD: a controversy.
Respiration; international review of thoracic diseases 2010;80(2):89-95.
2010: Paolo Montuschi; Peter J Barnes; Giovanni Ciabattoni
Measurement of 8-isoprostane in exhaled breath condensate.
Methods in molecular biology (Clifton, N.J.) 2010;594():73-84.
2010: Caterina Brindicci; Sergei A Kharitonov; Misako Ito; Mark W Elliott; James C Hogg; Peter J Barnes; Kazuhiro Ito
Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2010;181(1):21-30.
2009: Catherine E Charron; Pai-Chien Chou; David J C Coutts; Vaibhav Kumar; Masako To; Kenichi Akashi; Liao Pinhu; Mark Griffiths; Ian M Adcock; Peter J Barnes; Kazuhiro Ito
Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription.
The Journal of biological chemistry 2009;284(52):36047-54.
2009: Peter J Barnes
Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2009;6(8):693-6.
2009: Peter J Barnes
The cytokine network in chronic obstructive pulmonary disease.
American journal of respiratory cell and molecular biology 2009;41(6):631-8.
2009: Eric D Bateman; S Rennard; Peter J Barnes; Peter V Dicpinigaitis; R Gosens; N J Gross; J A Nadel; M Pfeifer; K Racké; K F Rabe; B K Rubin; T Welte; I Wessler
Alternative mechanisms for tiotropium.
Pulmonary pharmacology & therapeutics 2009;22(6):533-42.
2009: Antonino Di Stefano; Gaetano Caramori; Isabelle Gnemmi; Marco Contoli; L Bristot; Armando Capelli; Fabio L M Ricciardolo; F Magno; S Ennio D'Anna; A Zanini; M Carbone; F Sabatini; C Usai; P Brun; K Fan Chung; Peter J Barnes; Alberto Papi; Ian M Adcock; Bruno Balbi
Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD.
Thorax 2009;64(11):968-75.
2009: Peter J Barnes
Histone deacetylase-2 and airway disease.
Therapeutic advances in respiratory disease 2009;3(5):235-43.
2009: Robert A Stockley; David Mannino; Peter J Barnes
Burden and pathogenesis of chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2009;6(6):524-6.
2009: Gaetano Caramori; Paolo Casolari; Carmela Di Gregorio; Marina Saetta; Simonetta Baraldo; Piera Boschetto; Kazuhiro Ito; Leonardo M Fabbri; Peter J Barnes; Ian M Adcock; Giorgio Cavallesco; Kian F Chung; Alberto Papi
MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.
Histopathology 2009;55(3):321-31.
2009: Yuji Nakamaru; Chaitanya Vuppusetty; Hiroo Wada; Jill C Milne; Misako Ito; Christos Rossios; Mark Elliot; James Hogg; Sergei A Kharitonov; Hajime Goto; Jean E Bemis; Peter Elliott; Peter J Barnes; Kazuhiro Ito
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):2810-9.
2009: Trevor T Hansel; Peter J Barnes
New drugs for exacerbations of chronic obstructive pulmonary disease.
Lancet 2009;374(9691):744-55.
2009: Sundeep S Salvi; Peter J Barnes
Chronic obstructive pulmonary disease in non-smokers.
Lancet 2009;374(9691):733-43.
2009: Antonino Di Stefano; Gaetano Caramori; Isabelle Gnemmi; M Contoli; C Vicari; Armando Capelli; F Magno; S E D'Anna; A Zanini; P Brun; P Casolari; K Fan Chung; Peter J Barnes; A Papi; Ian M Adcock; B Balbi
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.
Clinical and experimental immunology 2009;157(2):316-24.
2009: Peter J Barnes
Intrinsic asthma: not so different from allergic asthma but driven by superantigens?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(8):1145-51.
2009: Grace O Osoata; Satoshi Yamamura; Misako Ito; Chaitanya Vuppusetty; Ian M Adcock; Peter J Barnes; Kazuhiro Ito
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.
Biochemical and biophysical research communications 2009;384(3):366-71.
2009: S Suissa; Peter J Barnes
Inhaled corticosteroids in COPD: the case against.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;34(1):13-6.
2009: Mark Spears; I Donnelly; L Jolly; M Brannigan; K Ito; Charles P McSharry; J Lafferty; Rekha Chaudhuri; G Braganza; P Bareille; L Sweeney; I M Adcock; Peter J Barnes; S Wood; Neil C Thomson
Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma.
Clinical pharmacology and therapeutics 2009;86(1):49-53.
2009: Alberto Papi; Gaetano Caramori; Ian M Adcock; Peter J Barnes
Rescue treatment in asthma. More than as-needed bronchodilation.
Chest 2009;135(6):1628-33.
2009: Grace O Osoata; Toyoyuki Hanazawa; Caterina Brindicci; Misako Ito; Peter J Barnes; Sergei A Kharitonov; Kazuhiro Ito
Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine.
Chest 2009;135(6):1513-20.
2009: Peter J Barnes; Ian M Adcock
Glucocorticoid resistance in inflammatory diseases.
Lancet 2009;373(9678):1905-17.
2009: Kittipong Maneechotesuwan; Xin Yao; Kazuhiro Ito; Elen Jazrawi; Omar S Usmani; Ian M Adcock; Peter J Barnes
Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease.
PLoS medicine 2009;6(5):e1000076.
2009: Peter J Barnes; B R Celli
Systemic manifestations and comorbidities of COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1165-85.
2009: P Paredi; Peter J Barnes
The airway vasculature: recent advances and clinical implications.
Thorax 2009;64(5):444-50.
2009: Mark Spears; I Donnelly; L Jolly; M Brannigan; K Ito; Charles P McSharry; J Lafferty; Rekha Chaudhuri; G Braganza; I M Adcock; Peter J Barnes; S Wood; Neil C Thomson
Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1010-7.
2009: T K Finney-Hayward; P Bahra; S Li; C T Poll; Andrew G Nicholson; R E K Russell; P A Ford; John Westwick; P S Fenwick; Peter J Barnes; Louise E Donnelly
Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1105-12.
2009: B G Cosio; A Iglesias; A Rios; A Noguera; E Sala; K Ito; Peter J Barnes; A Agusti
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD.
Thorax 2009;64(5):424-9.
2009: John A Marwick; Gaetano Caramori; Christopher S Stevenson; Paolo Casolari; Elen Jazrawi; Peter J Barnes; Kazuhiro Ito; Ian M Adcock; Paul A Kirkham; Alberto Papi
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.
American journal of respiratory and critical care medicine 2009;179(7):542-8.
2009: Sally E Wenzel; Peter J Barnes; Eugene R Bleecker; Jean Bousquet; William Busse; Sven-Erik Dahlén; Stephen T Holgate; Deborah A Meyers; Klaus F Rabe; Adam Antczak; James Baker; Ildiko Horvath; Zsuzsanna Mark; David Bernstein; Edward Kerwin; Rozsa Schlenker-Herceg; Kim Hung Lo; Rosemary Watt; Elliot S Barnathan; Pascal Chanez
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma.
American journal of respiratory and critical care medicine 2009;179(7):549-58.
2009: Gaetano Caramori; Tim Oates; Andrew G Nicholson; Paolo Casolari; Kazuhiro Ito; Peter J Barnes; Alberto Papi; Ian M Adcock; Kian Fan Chung
Activation of NF-kappaB transcription factor in asthma death.
Histopathology 2009;54(4):507-9.
2009: Lars Pedersen; Thomas K Lund; Ellen Mølgaard; Sergei A Kharitonov; Peter J Barnes; Vibeke Backer
The acute effect of swimming on airway inflammation in adolescent elite swimmers.
The Journal of allergy and clinical immunology 2009;123(2):502-4.
2009: Caterina Brindicci; Kazuhiro Ito; Olga Torre; Peter J Barnes; Sergei A Kharitonov
Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients.
Chest 2009;135(2):353-67.
2009: Paul A Ford; Richard E K Russell; Peter J Barnes
ICS and COPD: time to clear the air.
International journal of chronic obstructive pulmonary disease 2009;4():289-90.
2009: Kazuhiro Ito; Peter J Barnes
COPD as a disease of accelerated lung aging.
Chest 2009;135(1):173-80.
2009: Kittipong Maneechotesuwan; Valla Wamanuttajinda; Kanda Kasetsinsombat; Sukit Huabprasert; Metha Yaikwawong; Peter J Barnes; Adisak Wongkajornsilp
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma.
The Journal of allergy and clinical immunology 2009;123(1):239-48.
2009: Peter J Barnes
Role of HDAC2 in the pathophysiology of COPD.
Annual review of physiology 2009;71():451-64.
2008: John A Marwick; Gillian Wallis; Koremu Meja; Bernhard Kuster; Tewis Bouwmeester; Probir Chakravarty; Danielle Fletcher; Paul A Whittaker; Peter J Barnes; Kazuhiro Ito; Ian M Adcock; Paul A Kirkham
Oxidative stress modulates theophylline effects on steroid responsiveness.
Biochemical and biophysical research communications 2008;377(3):797-802.
2008: Peter J Barnes
Emerging pharmacotherapies for COPD.
Chest 2008;134(6):1278-86.
2008: Peter J Barnes
Future treatments for chronic obstructive pulmonary disease and its comorbidities.
Proceedings of the American Thoracic Society 2008;5(8):857-64.
2008: Paul M O'Byrne; Ian P Naya; Anders Kallen; Dirkje S Postma; Peter J Barnes
Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control.
Chest 2008;134(6):1192-9.
2008: Peter J Barnes
The cytokine network in asthma and chronic obstructive pulmonary disease.
The Journal of clinical investigation 2008;118(11):3546-56.
2008: Kazuhiro Ito; Cristan Herbert; Jessica S Siegle; Chaitanya Vuppusetty; Nicole Hansbro; Paul S Thomas; Paul S Foster; Peter J Barnes; Rakesh K Kumar
Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma.
American journal of respiratory cell and molecular biology 2008;39(5):543-50.
2008: O Torre; Dario Olivieri; Peter J Barnes; Sergei A Kharitonov
Feasibility and interpretation of FE(NO) measurements in asthma patients in general practice.
Respiratory medicine 2008;102(10):1417-24.
2008: Edward M Erin; Angela Zacharasiewicz; Grant C Nicholson; Andrew J Tan; Helen Neighbour; Renate Engelstätter; Michael Hellwig; Onn Min Kon; Peter J Barnes; Trevor T Hansel
Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study.
Chest 2008;134(4):740-5.
2008: Peter J Barnes
Defective antioxidant gene regulation in COPD: a case for broccoli.
American journal of respiratory and critical care medicine 2008;178(6):552-4.
2008: Vincenzina Lucidi; Giovanni Ciabattoni; Sergio Bella; Peter J Barnes; Paolo Montuschi
Exhaled 8-isoprostane and prostaglandin E(2) in patients with stable and unstable cystic fibrosis.
Free radical biology & medicine 2008;45(6):913-9.
2008: Manminder Kaur; Neil S Holden; Sylvia M Wilson; Maria B Sukkar; Kian Fan Chung; Peter J Barnes; Robert Newton; Mark A Giembycz
Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.
American journal of physiology. Lung cellular and molecular physiology 2008;295(3):L505-14.
2008: Pankaj Bhavsar; Mark Hew; Nadia M Khorasani; Alfons Torrego; Peter J Barnes; Ian M Adcock; K Fan Chung
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma.
Thorax 2008;63(9):784-90.
2008: Peter J Barnes
Role of GATA-3 in allergic diseases.
Current molecular medicine 2008;8(5):330-4.
2008: Ian M Adcock; Peter J Barnes
Molecular mechanisms of corticosteroid resistance.
Chest 2008;134(2):394-401.
2008: Lars Pedersen; Thomas K Lund; Peter J Barnes; Sergei A Kharitonov; Vibeke Backer
Airway responsiveness and inflammation in adolescent elite swimmers.
The Journal of allergy and clinical immunology 2008;122(2):322-7, 327.e1.
2008: Graham Sturton; Carl Persson; Peter J Barnes
Small airways: an important but neglected target in the treatment of obstructive airway diseases.
Trends in pharmacological sciences 2008;29(7):340-5.
2008: Heli Perttunen; Eeva Moilanen; Xianzhi Zhang; Peter J Barnes; Hannu Kankaanranta
Beta2-agonists potentiate corticosteroid-induced neutrophil survival.
COPD 2008;5(3):163-9.
2008: Peter J Barnes
Frontrunners in novel pharmacotherapy of COPD.
Current opinion in pharmacology 2008;8(3):300-7.
2008: Brian R Leaker; B O'Connor; Trevor T Hansel; Peter J Barnes; Lixen Meng; Vandana Mathur; Hsiao D Lieu
Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2008;15(3):329-36.
2008: Tehireem Ahmad; Peter J Barnes; Ian M Adcock
Overcoming steroid insensitivity in smoking asthmatics.
Current opinion in investigational drugs (London, England : 2000) 2008;9(5):470-7.
2008: Peter J Barnes
A blood test for lung fibrosis.
PLoS medicine 2008;5(4):e98.
2008: Federico Lavorini; Antoine Magnan; Jean Christophe Dubus; Thomas Voshaar; Lorenzo Corbetta; Marielle Broeders; Richard Dekhuijzen; Joaquin Sanchis; Jose L Viejo; Peter J Barnes; Chris Corrigan; Mark Levy; Graham K Crompton
Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD.
Respiratory medicine 2008;102(4):593-604.
2008: Peter J Barnes
Immunology of asthma and chronic obstructive pulmonary disease.
Nature reviews. Immunology 2008;8(3):183-92.
2008: Mario Cazzola; W MacNee; Fernando J Martinez; K F Rabe; L G Franciosi; Peter J Barnes; Vito Brusasco; P S Burge; P M A Calverley; B R Celli; P W Jones; Donald A Mahler; Barry Make; Marc Miravitlles; C P Page; Paolo Palange; D Parr; M Pistolesi; S I Rennard; M P Rutten-van Mölken; R Stockley; S D Sullivan; J A Wedzicha; E F Wouters
Outcomes for COPD pharmacological trials: from lung function to biomarkers.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(2):416-69.
2008: Edward M Erin; Gavin R Jenkins; Onn Min Kon; Angela Zacharasiewicz; Grant C Nicholson; Helen Neighbour; Rachel C Tennant; Andrew J Tan; Brian R Leaker; Andrew Bush; Peter J Jose; Peter J Barnes; Trevor T Hansel
Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants.
American journal of respiratory and critical care medicine 2008;177(2):132-41.
2008: Eric D Bateman; Suzanne S Hurd; Peter J Barnes; Jean Bousquet; Jeffrey M Drazen; M FitzGerald; P Gibson; K Ohta; Paul M O'Byrne; Søren E Pedersen; Emilio Pizzichini; S D Sullivan; S E Wenzel; H J Zar
Global strategy for asthma management and prevention: GINA executive summary.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(1):143-78.
2008: Kittipong Maneechotesuwan; Sirinya Supawita; Kanda Kasetsinsombat; Adisak Wongkajornsilp; Peter J Barnes
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids.
The Journal of allergy and clinical immunology 2008;121(1):43-50.
2008: Claudia Costa; Rogério Rufino; Suzanne L Traves; José Roberto Lapa e Silva; Peter J Barnes; Louise E Donnelly
CXCR3 and CCR5 chemokines in induced sputum from patients with COPD.
Chest 2008;133(1):26-33.
2008: J Christian Virchow; Graham K Crompton; R Dal Negro; S Pedersen; A Magnan; J Seidenberg; Peter J Barnes
Importance of inhaler devices in the management of airway disease.
Respiratory medicine 2008;102(1):10-9.
2008: Susan J Tudhope; Tricia K Finney-Hayward; Andrew G Nicholson; Ruth J Mayer; Mary S Barnette; Peter J Barnes; Louise E Donnelly
Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage.
The Journal of pharmacology and experimental therapeutics 2008;324(1):306-12.
2008: Richard G Sturton; Alexandre Trifilieff; Andrew G Nicholson; Peter J Barnes
Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices.
The Journal of pharmacology and experimental therapeutics 2008;324(1):270-5.
2007: Paolo Montuschi; Chiara Mondino; Pierluigi Koch; Giovanni Ciabattoni; Peter J Barnes; Giuseppe Baviera
Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma.
Chest 2007;132(6):1876-81.
2007: Susan J Tudhope; Matthew C Catley; Peter S Fenwick; Richard E K Russell; William L Rumsey; Robert Newton; Peter J Barnes; Louise E Donnelly
The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6237-45.
2007: Maria P Foschino Barbaro; Giovanna E Carpagnano; Antonio Spanevello; Maria Grazia Cagnazzo; Peter J Barnes
Inflammation, oxidative stress and systemic effects in mild chronic obstructive pulmonary disease.
International journal of immunopathology and pharmacology 2007;20(4):753-63.
2007: Klaus F Rabe; Suzanne Hurd; Antonio Anzueto; Peter J Barnes; Sonia A Buist; Peter Calverley; Yoshinosuke Fukuchi; Christine Jenkins; Robert Rodriguez-Roisin; Chris van Weel; Jan Zielinski
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
American journal of respiratory and critical care medicine 2007;176(6):532-55.
2007: Peter J Barnes
Using a combination inhaler (budesonide plus formoterol) as rescue therapy improves asthma control.
BMJ (Clinical research ed.) 2007;335(7618):513.
2007: Sterghios A Moschos; Simon W Jones; Mark M Perry; Andrew Williams; Jonas Sten Erjefalt; John J Turner; Peter J Barnes; Brian Stephen Sproat; Michael J Gait; Mark A Lindsay
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
Bioconjugate chemistry 2007;18(5):1450-9.
2007: Peter J Barnes
Introducing expert review of respiratory medicine.
Expert review of respiratory medicine 2007;1(1):1-2.
2007: Caterina Brindicci; Kazuhiro Ito; Peter J Barnes; Sergei A Kharitonov
Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers.
Chest 2007;132(2):581-8.
2007: Kittipong Maneechotesuwan; Sarah Essilfie-Quaye; Sergei A Kharitonov; Ian M Adcock; Peter J Barnes
Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils.
Chest 2007;132(1):98-105.
2007: Bartolome R Celli; Peter J Barnes
Exacerbations of chronic obstructive pulmonary disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(6):1224-38.
2007: Peter J Barnes
Prevention of death in COPD.
The New England journal of medicine 2007;356(21):2211; author reply 2213-4.
2007: Peter J Barnes
Chronic obstructive pulmonary disease: a growing but neglected global epidemic.
PLoS medicine 2007;4(5):e112.
2007: Caterina Brindicci; Kazuhiro Ito; Peter J Barnes; Sergei A Kharitonov
Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity.
Chest 2007;131(5):1353-62.
2007: Peter J Barnes
Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2007;175(9):866-7.
2007: Peter J Barnes
New molecular targets for the treatment of neutrophilic diseases.
The Journal of allergy and clinical immunology 2007;119(5):1055-62; quiz 1063-4.
2007: Robert Newton; Neil S Holden; Matthew C Catley; Wale Oyelusi; Richard Leigh; David Proud; Peter J Barnes
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
The Journal of pharmacology and experimental therapeutics 2007;321(2):734-42.
2007: Paolo Paredi; Simon Ward; Derek Cramer; Peter J Barnes; Sergei A Kharitonov
Normal bronchial blood flow in COPD is unaffected by inhaled corticosteroids and correlates with exhaled nitric oxide.
Chest 2007;131(4):1075-81.
2007: Peter J Barnes
Scientific rationale for using a single inhaler for asthma control.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(3):587-95.
2007: Kittipong Maneechotesuwan; Yao Xin; Kazuhiro Ito; Elen Jazrawi; Kang-Yun Lee; Omar S Usmani; Peter J Barnes; Ian M Adcock
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2491-8.
2007: Andrew Williams; Sterghios A Moschos; Mark M Perry; Peter J Barnes; Mark A Lindsay
Maternally imprinted microRNAs are differentially expressed during mouse and human lung development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(2):572-80.
2007: Paul A Ford; Peter J Barnes; Omar S Usmani
Chronic cough and Holmes-Adie syndrome.
Lancet 2007;369(9558):342.
2007: Paolo Montuschi; Peter J Barnes; L Jackson Roberts
Insights into oxidative stress: the isoprostanes.
Current medicinal chemistry 2007;14(6):703-17.
2007: Peter J Barnes
The problem of cough and development of novel antitussives.
Pulmonary pharmacology & therapeutics 2007;20(4):416-22.
2007: Grant C Nicholson; Rachel C Tennant; Donald C Carpenter; Henry M Sarau; Onn Min Kon; Peter J Barnes; Michael Salmon; Rupert S Vessey; Ruth Tal-Singer; Trevor T Hansel
A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist.
Pulmonary pharmacology & therapeutics 2007;20(1):52-9.
2006: Silvana Morello; Kazuhiro Ito; Satoshi Yamamura; Kang-Yun Lee; Elen Jazrawi; Patricia Desouza; Peter J Barnes; Carla Cicala; Ian M Adcock
IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7173-83.
2006: Peter J Barnes
[Future therapies for chronic obstructive pulmonary disease].
Zhonghua yi xue za zhi 2006;86(41):2884-6.
2006: Sergei A Kharitonov; Peter J Barnes
Exhaled biomarkers.
Chest 2006;130(5):1541-6.
2006: Nisha Vasavda; Thomas Eichholtz; Atsushi Takahashi; Karen Affleck; John G Matthews; Peter J Barnes; Ian M Adcock
Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma.
The Journal of allergy and clinical immunology 2006;118(5):1090-6.
2006: Peter J Barnes
Treatment with (R)-albuterol has no advantage over racemic albuterol.
American journal of respiratory and critical care medicine 2006;174(9):969-72; discussion 972-4.
2006: Peter J Barnes
New therapies for asthma.
Trends in molecular medicine 2006;12(11):515-20.
2006: Susan J Smith; Peter S Fenwick; Andrew G Nicholson; F Kirschenbaum; T K Finney-Hayward; Linda S Higgins; Mark A Giembycz; Peter J Barnes; Louise E Donnelly
Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages.
British journal of pharmacology 2006;149(4):393-404.
2006: Louise E Donnelly; Peter J Barnes
Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease.
Trends in pharmacological sciences 2006;27(10):546-53.
2006: Edward M Erin; Brian R Leaker; Grant C Nicholson; Andrew J Tan; Linda M Green; Helen Neighbour; Angela Zacharasiewicz; Jackie Turner; Elliot S Barnathan; Onn Min Kon; Peter J Barnes; Trevor T Hansel
The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma.
American journal of respiratory and critical care medicine 2006;174(7):753-62.
2006: Peter J Barnes
Theophylline for COPD.
Thorax 2006;61(9):742-4.
2006: Peter J Barnes
Transcription factors in airway diseases.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):867-72.
2006: Graham K Crompton; Peter J Barnes; M Broeders; C Corrigan; L Corbetta; R Dekhuijzen; J C Dubus; A Magnan; F Massone; J Sanchis; J L Viejo; T Voshaar
The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement Team.
Respiratory medicine 2006;100(9):1479-94.
2006: Paolo Montuschi; Chiara Mondino; Pierluigi Koch; Peter J Barnes; Giovanni Ciabattoni
Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma.
The Journal of allergy and clinical immunology 2006;118(2):347-53.
2006: Peter J Barnes
Against the Dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases.
American journal of respiratory and critical care medicine 2006;174(3):240-3; discussion 243-4.
2006: Matthew C Catley; Maria B Sukkar; K Fan Chung; Bruce Jaffee; Sha-Mei Liao; Anthony J Coyle; El-Bdaoui Haddad; Peter J Barnes; Robert Newton
Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.
Molecular pharmacology 2006;70(2):697-705.
2006: Emmanouil Paraskakis; Caterina Brindicci; Louise Fleming; Renata Krol; Sergei A Kharitonov; Nicola M Wilson; Peter J Barnes; Andrew Bush
Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma.
American journal of respiratory and critical care medicine 2006;174(3):260-7.
2006: Peter J Barnes
ABC of chronic obstructive pulmonary disease. Future treatments.
BMJ (Clinical research ed.) 2006;333(7561):246-8.
2006: Mark Hew; Pankaj Bhavsar; Alfons Torrego; Sally Meah; Nadia M Khorasani; Peter J Barnes; Ian M Adcock; K Fan Chung
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.
American journal of respiratory and critical care medicine 2006;174(2):134-41.
2006: Peter J Barnes; Badrul A Chowdhury; Sergei A Kharitonov; Helgo Magnussen; Clive P Page; Dirkje Postma; Marina Saetta
Pulmonary biomarkers in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2006;174(1):6-14.
2006: Trevor T Hansel; Olivier Benezet; Henri Kafé; Hans-Hermann Ponitz; David Cheung; Renate Engelstätter; Peter J Barnes
A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma.
Clinical therapeutics 2006;28(6):906-20.
2006: Adam Barczyk; Władysław Pierzchała; Onn Min Kon; Borja Cosio; Ian M Adcock; Peter J Barnes
Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease.
The Journal of allergy and clinical immunology 2006;117(6):1484-92.
2006: Peter J Barnes
How corticosteroids control inflammation: Quintiles Prize Lecture 2005.
British journal of pharmacology 2006;148(3):245-54.
2006: Giovanni Invernizzi; Roberto Boffi; Ario Ruprecht; Peter J Barnes; Sergei A Kharitonov; Paolo Paredi
Real-time measurement of particulate matter deposition in the lung.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2006;11(3):221-32.
2006: Graham K Crompton; Peter J Barnes
Aerosol delivery devices.
Chest 2006;129(5):1388-9; author reply 1389.
2006: Peter J Barnes
Receptor heterodimerization: a new level of cross-talk.
The Journal of clinical investigation 2006;116(5):1210-2.
2006: Edward M Erin; Brian R Leaker; Angela Zacharasiewicz; Lorna A Higgins; Grant C Nicholson; M J Boyce; P de Boer; R C Jones; Stephen R Durham; Peter J Barnes; Trevor T Hansel
Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(4):458-64.
2006: Peter J Barnes
Corticosteroids: the drugs to beat.
European journal of pharmacology 2006;533(1-3):2-14.
2006: Katia Varani; Gaetano Caramori; Fabrizio Vincenzi; Ian Adcock; Paolo Casolari; Edward Leung; Stephen Maclennan; Stefania Gessi; Silvana Morello; Peter J Barnes; Kazuhiro Ito; K Fan Chung; Giorgio Cavallesco; Gianfranco Azzena; Alberto Papi; Pier Andrea Borea
Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2006;173(4):398-406.
2006: Peter J Barnes
Corticosteroid effects on cell signalling.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;27(2):413-26.
2006: Kazuhiro Ito; Satoshi Yamamura; Sarah Essilfie-Quaye; Borja Cosio; Misako Ito; Peter J Barnes; Ian M Adcock
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression.
The Journal of experimental medicine 2006;203(1):7-13.
2006: Martyn F Biddiscombe; Peter J Barnes; Omar S Usmani
Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2006;19(3):245-53.
2006: Laura Moreno; F Perez-Vizcaino; L Harrington; R Faro; Graham Sturton; Peter J Barnes; Jane A Mitchell
Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones.
Respiratory research 2006;7():111.
2006: Christiane Lex; Angela Zacharasiewicz; Donald N R Payne; Nicola M Wilson; Andrew G Nicholson; Sergei A Kharitonov; Peter J Barnes; Andrew Bush
Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study.
Respiratory research 2006;7():63.
2006: Duncan F Rogers; Peter J Barnes
Treatment of airway mucus hypersecretion.
Annals of medicine 2006;38(2):116-25.
2006: Ian M Adcock; Paul Ford; Kazuhiro Ito; Peter J Barnes
Epigenetics and airways disease.
Respiratory research 2006;7():21.
2006: Peter J Barnes
Reduced histone deacetylase in COPD: clinical implications.
Chest 2006;129(1):151-5.
2006: Peter J Barnes
Drugs for asthma.
British journal of pharmacology 2006;147 Suppl 1():S297-303.
2006: Kang-Yun Lee; Kazuhiro Ito; Ryuji Hayashi; Elen Jazrawi; Peter J Barnes; Ian M Adcock
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):603-15.
2006: Peter J Barnes
Novel signal transduction modulators for the treatment of airway diseases.
Pharmacology & therapeutics 2006;109(1-2):238-45.
2005: Omar S Usmani; Martyn F Biddiscombe; Peter J Barnes
Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size.
American journal of respiratory and critical care medicine 2005;172(12):1497-504.
2005: Peter J Barnes
Emerging targets for COPD therapy.
Current drug targets. Inflammation and allergy 2005;4(6):675-83.
2005: Ian M Adcock; Kazuhiro Ito; Peter J Barnes
Histone deacetylation: an important mechanism in inflammatory lung diseases.
COPD 2005;2(4):445-55.
2005: Edward M Erin; Angela Zacharasiewicz; Grant C Nicholson; Andrew J Tan; Lorna A Higgins; Timothy J Williams; R D Murdoch; Stephen R Durham; Peter J Barnes; Trevor T Hansel
Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(12):1608-14.
2005: Peter J Barnes
Targeting histone deacetylase 2 in chronic obstructive pulmonary disease treatment.
Expert opinion on therapeutic targets 2005;9(6):1111-21.
2005: Edward M Erin; Brian R Leaker; Angela Zacharasiewicz; Lorna A Higgins; Timothy J Williams; M J Boyce; P de Boer; Stephen R Durham; Peter J Barnes; Trevor T Hansel
Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge.
Allergy 2005;60(12):1524-9.
2005: Fabio L M Ricciardolo; Gaetano Caramori; Kazuhiro Ito; Armando Capelli; Paola Brun; Giovanni Abatangelo; Alberto Papi; K Fan Chung; Ian Adcock; Peter J Barnes; Claudio F Donner; Andrea Rossi; Antonino Di Stefano
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease.
The Journal of allergy and clinical immunology 2005;116(5):1028-35.
2005: Adam Antczak; Sergei A Kharitonov; Paolo Montuschi; Pawel Gorski; Peter J Barnes
Inflammatory response to sputum induction measured by exhaled markers.
Respiration; international review of thoracic diseases 2005;72(6):594-9.
2005: Trevor T Hansel; Helen Neighbour; Edward M Erin; Andrew J Tan; Rachel C Tennant; Joachim G Maus; Peter J Barnes
Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma.
Chest 2005;128(4):1974-9.
2005: Wojciech A Biernacki; Sergei A Kharitonov; Helen M Biernacka; Peter J Barnes
Effect of montelukast on exhaled leukotrienes and quality of life in asthmatic patients.
Chest 2005;128(4):1958-63.
2005: Kittipong Maneechotesuwan; Sarah Essilfie-Quaye; Sally Meah; Claire Kelly; Sergei A Kharitonov; Ian M Adcock; Peter J Barnes
Formoterol attenuates neutrophilic airway inflammation in asthma.
Chest 2005;128(4):1936-42.
2005: Ozen K Basoglu; Amir Pelleg; Sarah Essilfie-Quaye; Caterina Brindicci; Peter J Barnes; Sergei A Kharitonov
Effects of aerosolized adenosine 5'-triphosphate vs adenosine 5'-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma.
Chest 2005;128(4):1905-9.
2005: Paolo Montuschi; F Macagno; P Parente; S Valente; L Lauriola; Giuliano Ciappi; Sergei A Kharitonov; Peter J Barnes; Giovanni Ciabattoni
Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD.
Thorax 2005;60(10):827-33.
2005: Omar S Usmani; Kazuhiro Ito; Kittipong Maneechotesuwan; Misako Ito; Malcolm Johnson; Peter J Barnes; Ian M Adcock
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.
American journal of respiratory and critical care medicine 2005;172(6):704-12.
2005: Peter J Barnes
[How should clinical practice guidelines be implemented? Conclusion].
Revue de pneumologie clinique 2005;61(Spec no. 2):3S29-30.
2005: I Horváth; J Hunt; Peter J Barnes; K Alving; A Antczak; E Baraldi; G Becher; W J C van Beurden; M Corradi; R Dekhuijzen; raed dweik; T Dwyer; R Effros; S Erzurum; B Gaston; C Gessner; A Greening; L P Ho; J Hohlfeld; Q Jöbsis; D Laskowski; S Loukides; D Marlin; P Montuschi; A C Olin; A E Redington; P Reinhold; E L J van Rensen; I Rubinstein; P Silkoff; K Toren; G Vass; C Vogelberg; H Wirtz
Exhaled breath condensate: methodological recommendations and unresolved questions.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;26(3):523-48.
2005: Sergei A Kharitonov; Lynda Walker; Peter J Barnes
Repeatability of standardised nasal nitric oxide measurements in healthy and asthmatic adults and children.
Respiratory medicine 2005;99(9):1105-14.
2005: Rakesh Sharma; Aidan P Bolger; Mathias Rauchhaus; Stephan von Haehling; Wolfram Doehner; Ian M Adcock; Peter J Barnes; Philip A Poole-Wilson; Hans-Dieter Volk; Andrew J S Coats; Sam Lim; Stefan D Anker
Cellular endotoxin desensitization in patients with severe chronic heart failure.
European journal of heart failure 2005;7(5):865-8.
2005: Peter J Barnes
Molecular mechanisms and cellular effects of glucocorticosteroids.
Immunology and allergy clinics of North America 2005;25(3):451-68.
2005: Peter J Barnes
Will it be steroids for ever?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(7):843-5.
2005: Caterina Brindicci; Kazuhiro Ito; Onofrio Resta; Neil B Pride; Peter J Barnes; Sergei A Kharitonov
Exhaled nitric oxide from lung periphery is increased in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;26(1):52-9.
2005: Gaetano Caramori; M Fabbri; D Paioli; F Falcone; C Severino; G Felisatti; okan arar; I M Adcock; K Fan Chung; Peter J Barnes; Adalberto Ciaccia; Alberto Papi
Asthma is not a common cause of severe chronic respiratory failure in non-smokers: ALOT study.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 2005;63(2):84-7.
2005: Giovanna E Carpagnano; Maria P Foschino Barbaro; Onofrio Resta; Peter J Barnes
Oxidative stress and cardiovascular complications in sleep apnea.
Chest 2005;127(6):2294.
2005: Peter J Barnes; R A Stockley
COPD: current therapeutic interventions and future approaches.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(6):1084-106.
2005: Sarah V Culpitt; Duncan F Rogers; Suzanne L Traves; Peter J Barnes; Louise E Donnelly
Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma.
Respiratory medicine 2005;99(6):703-10.
2005: Hiroo Wada; Masahiko Kagoshima; Kazuhiro Ito; Peter J Barnes; Ian M Adcock
5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene.
Biochemical and biophysical research communications 2005;331(1):93-9.
2005: Kazuhiro Ito; Misako Ito; W Mark Elliott; Borja Cosio; Gaetano Caramori; Onn Min Kon; Adam Barczyk; Shizu Hayashi; Ian M Adcock; James C Hogg; Peter J Barnes
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
The New England journal of medicine 2005;352(19):1967-76.
2005: Rubaiyat A Haque; Omar S Usmani; Peter J Barnes
Chronic idiopathic cough: a discrete clinical entity?
Chest 2005;127(5):1710-3.
2005: Mark A Birrell; Kerryn McCluskie; Sissie Wong; Louise E Donnelly; Peter J Barnes; Maria G Belvisi
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):840-1.
2005: Matthew C Catley; Joanna E Chivers; Neil S Holden; Peter J Barnes; Robert Newton
Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells.
British journal of pharmacology 2005;145(1):114-22.
2005: Peter J Barnes; Ian M Adcock; Kazuhiro Ito
Histone acetylation and deacetylation: importance in inflammatory lung diseases.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(3):552-63.
2005: Omar S Usmani; Maria G Belvisi; Hema J Patel; Natascia Crispino; Mark A Birrell; Marta Korbonits; Dezso Korbonits; Peter J Barnes
Theobromine inhibits sensory nerve activation and cough.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):231-3.
2005: Peter J Barnes
A single inhaler for asthma?
American journal of respiratory and critical care medicine 2005;171(2):95-6.
2005: Peter J Barnes
Theophylline in chronic obstructive pulmonary disease: new horizons.
Proceedings of the American Thoracic Society 2005;2(4):334-9; discussion 340-1.
2005: Paolo Montuschi; Simona Martello; Marialinda Felli; Chiara Mondino; Peter J Barnes; Marcello Chiarotti
Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children.
Respiratory research 2005;6():119.
2005: Peter J Barnes
Achieving asthma control.
Current medical research and opinion 2005;21 Suppl 4():S5-9.
2005: Peter J Barnes
Introduction: how can we improve asthma management?
Current medical research and opinion 2005;21 Suppl 4():S1-3.
2005: Sukhbir K Shahid; Sergei A Kharitonov; Nicola M Wilson; Andrew Bush; Peter J Barnes
Exhaled 8-isoprostane in childhood asthma.
Respiratory research 2005;6():79.
2005: Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Correlation of exhaled breath temperature with bronchial blood flow in asthma.
Respiratory research 2005;6():15.
2005: Ian M Adcock; Borja Cosio; Loukia Tsaprouni; Peter J Barnes; Kazuhiro Ito
Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.
Antioxidants & redox signaling 2005;7(1-2):144-52.
2004: Peter J Barnes
The role of anticholinergics in chronic obstructive pulmonary disease.
The American journal of medicine 2004;117 Suppl 12A():24S-32S.
2004: Peter J Barnes
New drugs for asthma.
Discovery medicine 2004;4(24):421-6.
2004: Peter J Barnes
Mediators of chronic obstructive pulmonary disease.
Pharmacological reviews 2004;56(4):515-48.
2004: Paolo Montuschi; Peter J Barnes; L Jackson Roberts
Isoprostanes: markers and mediators of oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1791-800.
2004: Giovanna E Carpagnano; Sergei A Kharitonov; Maria P Foschino Barbaro; Onofrio Resta; Enzo Gramiccioni; Peter J Barnes
Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation.
Thorax 2004;59(12):1016-9.
2004: Susan J Smith; Lenora B Cieslinski; Robert Newton; Louise E Donnelly; Peter S Fenwick; Andrew G Nicholson; Peter J Barnes; Mary S Barnette; Mark A Giembycz
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.
Molecular pharmacology 2004;66(6):1679-89.
2004: Gaetano Caramori; C Di Gregorio; I Carlstedt; Paolo Casolari; I Guzzinati; Ian Adcock; Peter J Barnes; Adalberto Ciaccia; Giorgio Cavallesco; K Fan Chung; Alberto Papi
Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease.
Histopathology 2004;45(5):477-84.
2004: Peter J Barnes; Manuel G Cosio
Characterization of T lymphocytes in chronic obstructive pulmonary disease.
PLoS medicine 2004;1(1):e20.
2004: Peter J Barnes
The size of the problem of managing asthma.
Respiratory medicine 2004;98 Suppl B():S4-8.
2004: Peter J Barnes
Decision making in asthma therapy--what is important in clinical practice?
Respiratory medicine 2004;98 Suppl B():S1-3.
2004: Chiara Mondino; Giovanni Ciabattoni; Pierluigi Koch; Riccardo Pistelli; Andrea Trové; Peter J Barnes; Paolo Montuschi
Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children.
The Journal of allergy and clinical immunology 2004;114(4):761-7.
2004: Joanna E Chivers; Lisa M Cambridge; Matthew C Catley; Judith C W Mak; Louise E Donnelly; Peter J Barnes; Robert Newton
Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.
European journal of biochemistry / FEBS 2004;271(20):4042-52.
2004: Peter J Barnes
New drugs for asthma.
Nature reviews. Drug discovery 2004;3(10):831-44.
2004: Louise E Donnelly; Peter J Barnes
Acidic mammalian chitinase--a potential target for asthma therapy.
Trends in pharmacological sciences 2004;25(10):509-11.
2004: Louise E Donnelly; Robert Newton; Gina E Kennedy; Peter S Fenwick; Rachel H F Leung; Kazuhiro Ito; Richard E K Russell; Peter J Barnes
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L774-83.
2004: Peter J Barnes; Trevor T Hansel
Prospects for new drugs for chronic obstructive pulmonary disease.
Lancet 2004;364(9438):985-96.
2004: Borja Cosio; Loukia Tsaprouni; Kazuhiro Ito; Elen Jazrawi; Ian M Adcock; Peter J Barnes
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.
The Journal of experimental medicine 2004;200(5):689-95.
2004: Ildikó Horváth; Louise E Donnelly; András Kiss; Beata Balint; Sergei A Kharitonov; Peter J Barnes
Exhaled nitric oxide and hydrogen peroxide concentrations in asthmatic smokers.
Respiration; international review of thoracic diseases 2004;71(5):463-8.
2004: Masakazu Ichinose; Peter J Barnes
Cytokine-directed therapy in asthma.
Current drug targets. Inflammation and allergy 2004;3(3):263-9.
2004: Peter J Barnes; Sabine Kleinert
COPD--a neglected disease.
Lancet 2004;364(9434):564-5.
2004: Suzanne L Traves; Susan J Smith; Peter J Barnes; Louise E Donnelly
Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2.
Journal of leukocyte biology 2004;76(2):441-50.
2004: Borja G Cosío; Buphinder Mann; Kazuhiro Ito; Elen Jazrawi; Peter J Barnes; K Fan Chung; Ian M Adcock
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.
American journal of respiratory and critical care medicine 2004;170(2):141-7.
2004: D Bumbacea; D Campbell; L Nguyen; D Carr; Peter J Barnes; D Robinson; K F Chung
Parameters associated with persistent airflow obstruction in chronic severe asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(1):122-8.
2004: Antonino Di Stefano; Gaetano Caramori; Armando Capelli; Isabelle Gnemmi; Fabio L M Ricciardolo; Timothy Oates; Claudio F Donner; K Fan Chung; Peter J Barnes; Ian M Adcock
STAT4 activation in smokers and patients with chronic obstructive pulmonary disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(1):78-85.
2004: Enrica Bucchioni; Zsuzsanna Csoma; Luigi Allegra; K Fan Chung; Peter J Barnes; Sergei A Kharitonov
Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma.
Respiratory medicine 2004;98(7):651-5.
2004: Peter J Barnes
Small airways in COPD.
The New England journal of medicine 2004;350(26):2635-7.
2004: John G Matthews; Kazuhiro Ito; Peter J Barnes; Ian M Adcock
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients.
The Journal of allergy and clinical immunology 2004;113(6):1100-8.
2004: MJ Leckie; A H Gomma; I F Purcell; B Nyawo; A Dewar; D Okrongly; John F Burman; J Hooper; Peter J Barnes; JR Clague; Trevor T Hansel
Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia.
International journal of cardiology 2004;95(2-3):307-13.
2004: Luigi Atzori; Gaetano Caramori; Sam Lim; Elen Jazrawi; Louise Donnelly; Ian M Adcock; Peter J Barnes; K Fan Chung
Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages.
Respiratory medicine 2004;98(6):530-5.
2004: Giovanna E Carpagnano; Peter J Barnes; Jackie Francis; Nicola Wilson; Andrew Bush; Sergei A Kharitonov
Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation?
Chest 2004;125(6):2005-10.
2004: P Cáp; J Chládek; F Pehal; M Malý; V Petrů; Peter J Barnes; P Montuschi
Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients.
Thorax 2004;59(6):465-70.
2004: Peter J Barnes
COPD: is there light at the end of the tunnel?
Current opinion in pharmacology 2004;4(3):263-72.
2004: Sam Lim; Gaetano Caramori; Katsuyuki Tomita; Elen Jazrawi; Timothy Oates; K Fan Chung; Peter J Barnes; Ian M Adcock
Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages.
Allergy 2004;59(5):505-14.
2004: koremu meja; Matthew C Catley; Lisa M Cambridge; Peter J Barnes; Hazel Lum; Robert Newton; Mark A Giembycz
Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89.
The Journal of pharmacology and experimental therapeutics 2004;309(2):833-44.
2004: Matthew C Catley; Lisa M Cambridge; Yasuyuki Nasuhara; Kazuhiro Ito; Joanna E Chivers; Andrew Beaton; Neil S Holden; Martin W Bergmann; Peter J Barnes; Robert Newton
Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding.
The Journal of biological chemistry 2004;279(18):18457-66.
2004: Peter J Barnes
Alveolar macrophages as orchestrators of COPD.
COPD 2004;1(1):59-70.
2004: James D Crapo; Peter J Barnes; Leonardo Fabbri; Suzanne Hurd; Barry Make; Ronald C Balkissoon
Editorial: the Journal of COPD--new directions in disease understanding and management.
COPD 2004;1(1):1-3.
2004: Peter J Barnes
Asthma management: can we further improve compliance and outcomes?
Respiratory medicine 2004;98 Suppl A():S8-9.
2004: Peter J Barnes
Asthma guidelines: recommendations versus reality.
Respiratory medicine 2004;98 Suppl A():S1-7.
2004: Martin W Bergmann; Karl J Staples; Peter J Barnes; Robert Newton
Nuclear factor-kappaB does not mediate the inhibitory effects of dexamethasone on granulocyte-macrophage colony-stimulating factor expression.
Immunology 2004;111(4):430-4.
2004: Martin W Bergmann; Karl J Staples; Susan J Smith; Peter J Barnes; Robert Newton
Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0.
American journal of respiratory cell and molecular biology 2004;30(4):555-63.
2004: Hisamichi Yuda; Yukihiko Adachi; Osamu Taguchi; Esteban C Gabazza; Osamu Hataji; Hajime Fujimoto; Shigenori Tamaki; Kimiaki Nishikubo; Kenji Fukudome; Corina N D'Alessandro-Gabazza; Junko Maruyama; Masahiko Izumizaki; Michiko Iwase; Ikuo Homma; Ryo Inoue; Haruhiko Kamada; Tatsuya Hayashi; Michael Kasper; Bart N Lambrecht; Peter J Barnes; Koji Suzuki
Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice.
Blood 2004;103(6):2196-204.
2004: Andrea Koch; Mark Giembycz; Kazuhiro Ito; Sam Lim; Elen Jazrawi; Peter J Barnes; Ian M Adcock; Erland Erdmann; K Fan Chung
Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.
American journal of respiratory cell and molecular biology 2004;30(3):342-9.
2004: Peter J Barnes; Kazuhiro Ito; Ian M Adcock
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.
Lancet 2004;363(9410):731-3.
2004: Kazuhiro Ito; Toyoyuki Hanazawa; Katsuyuki Tomita; Peter J Barnes; Ian M Adcock
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
Biochemical and biophysical research communications 2004;315(1):240-5.
2004: Neil S Holden; Matthew C Catley; Lisa M Cambridge; Peter J Barnes; Robert Newton
ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK.
European journal of biochemistry / FEBS 2004;271(4):785-91.
2004: Peter J Barnes
Ceramide lances the lungs.
Nature medicine 2004;10(2):130-1.
2004: Russell P Bowler; Peter J Barnes; James D Crapo
The role of oxidative stress in chronic obstructive pulmonary disease.
COPD 2004;1(2):255-77.
2004: Peter J Barnes
Distribution of receptor targets in the lung.
Proceedings of the American Thoracic Society 2004;1(4):345-51.
2004: Peter J Barnes
Corticosteroid resistance in airway disease.
Proceedings of the American Thoracic Society 2004;1(3):264-8.
2004: Ian M Adcock; Kaz Ito; Peter J Barnes
Glucocorticoids: effects on gene transcription.
Proceedings of the American Thoracic Society 2004;1(3):247-54.
2004: Sergei A Kharitonov; Peter J Barnes
Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2004;1(3):191-9.
2004: Peter J Barnes
Alveolar macrophages in chronic obstructive pulmonary disease (COPD).
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50 Online Pub():OL627-37.
2004: Hannu Kankaanranta; Aarne Lahdensuo; Eeva Moilanen; Peter J Barnes
Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review.
Respiratory research 2004;5():17.
2004: Trevor T Hansel; Rachel C Tennant; Andrew J Tan; Lorna A Higgins; Helen Neighbour; Edward M Erin; Peter J Barnes
Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease.
Drugs of today (Barcelona, Spain : 1998) 2004;40(1):55-69.
2004: Omar S Usmani; Martyn F Biddiscombe; S Richard Underwood; Peter J Barnes
Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top aerosol generator.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(1):69-73.
2003: Enrica Bucchioni; Sergei A Kharitonov; Luigi Allegra; Peter J Barnes
High levels of interleukin-6 in the exhaled breath condensate of patients with COPD.
Respiratory medicine 2003;97(12):1299-302.
2003: Peter J Barnes
Cytokine-directed therapies for the treatment of chronic airway diseases.
Cytokine & growth factor reviews 2003;14(6):511-22.
2003: Sarah V Culpitt; Duncan F Rogers; Peter S Fenwick; Pallav Shah; C J S de Matos; Richard E K Russell; Peter J Barnes; Louise E Donnelly
Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD.
Thorax 2003;58(11):942-6.
2003: Maxine Allen; Andrea Heinzmann; Emiko Noguchi; Goncalo Abecasis; John Broxholme; Chris P Ponting; Sumit Bhattacharyya; Jon Tinsley; Youming Zhang; Richard Holt; E Yvonne Jones; Nicholas J Lench; Alisoun Carey; Helene Jones; Nicholas J Dickens; Claire Dimon; Rosie Nicholls; Crystal Baker; Luzheng Xue; Elizabeth Townsend; Michael Kabesch; Stephan K Weiland; David Carr; Erika von Mutius; Ian M Adcock; Peter J Barnes; G Mark Lathrop; Mark Edwards; Miriam F Moffatt; William O C M Cookson
Positional cloning of a novel gene influencing asthma from chromosome 2q14.
Nature genetics 2003;35(3):258-63.
2003: Omar S Usmani; Martyn F Biddiscombe; Julia A Nightingale; S Richard Underwood; Peter J Barnes
Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(5):2106-12.
2003: Peter J Barnes; S D Shapiro; Romain A Pauwels
Chronic obstructive pulmonary disease: molecular and cellular mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(4):672-88.
2003: Giovanna E Carpagnano; Sergei A Kharitonov; Onofrio Resta; Maria P Foschino Barbaro; Enzo Gramiccioni; Peter J Barnes
8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
Chest 2003;124(4):1386-92.
2003: Peter J Barnes; Ian M Adcock
How do corticosteroids work in asthma?
Annals of internal medicine 2003;139(5 Pt 1):359-70.
2003: Douglas S Robinson; D A Campbell; Stephen R Durham; J Pfeffer; Peter J Barnes; K Fan Chung
Systematic assessment of difficult-to-treat asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(3):478-83.
2003: Masakazu Ichinose; Hisatoshi Sugiura; Shunsuke Yamagata; Akira Koarai; Masafumi Tomaki; Hiromasa Ogawa; Yuichi Komaki; Peter J Barnes; Kunio Shirato; Toshio Hattori
Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(3):457-61.
2003: Hema J Patel; Mark A Birrell; Natascia Crispino; David J Hele; Priya Venkatesan; Peter J Barnes; Magdi H Yacoub; Maria G Belvisi
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.
British journal of pharmacology 2003;140(2):261-8.
2003: Peter J Barnes
Chronic obstructive pulmonary disease * 12: New treatments for COPD.
Thorax 2003;58(9):803-8.
2003: Stephan von Haehling; Sabine Genth-Zotz; Rakesh Sharma; Aidan P Bolger; Wolfram Doehner; Peter J Barnes; Andrew J S Coats; Stefan D Anker
The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure.
International journal of cardiology 2003;90(2-3):197-204.
2003: Zsuzsanna Csoma; Andrew Bush; Nicola M Wilson; Louise Donnelly; Beatrix Balint; Peter J Barnes; Sergei A Kharitonov
Nitric oxide metabolites are not reduced in exhaled breath condensate of patients with primary ciliary dyskinesia.
Chest 2003;124(2):633-8.
2003: Karl J Staples; Martin W Bergmann; Peter J Barnes; Robert Newton
Evidence for post-transcriptional regulation of interleukin-5 by dexamethasone.
Immunology 2003;109(4):527-35.
2003: Matthew C Catley; Joanna E Chivers; Lisa M Cambridge; Neil S Holden; Donna M Slater; Karl J Staples; Martin W Bergmann; Peter Loser; Peter J Barnes; Robert Newton
IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase.
FEBS letters 2003;547(1-3):75-9.
2003: Eugenio Baraldi; Laura Ghiro; Vania Piovan; Silvia Carraro; Giovanni Ciabattoni; Peter J Barnes; Paolo Montuschi
Increased exhaled 8-isoprostane in childhood asthma.
Chest 2003;124(1):25-31.
2003: Xianzhi Zhang; Eeva Moilanen; Aleksi Lahti; Mari Hämäläinen; Mark A Giembycz; Peter J Barnes; Mark A Lindsay; Hannu Kankaanranta
Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.
The Journal of allergy and clinical immunology 2003;112(1):93-101.
2003: Paolo Montuschi; Sergei A Kharitonov; Giovanni Ciabattoni; Peter J Barnes
Exhaled leukotrienes and prostaglandins in COPD.
Thorax 2003;58(7):585-8.
2003: Trevor T Hansel; Sergei A Kharitonov; Louise E Donnelly; Edward M Erin; Mark G Currie; William M Moore; Pamela T Manning; David P Recker; Peter J Barnes
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1298-300.
2003: Rachel C Tennant; Edward M Erin; Peter J Barnes; Trevor T Hansel
Long-acting beta 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified?
Current opinion in pharmacology 2003;3(3):270-6.
2003: Peter J Barnes
Anti-leukotrienes: here to stay?
Current opinion in pharmacology 2003;3(3):257-63.
2003: Youming Zhang; Nicholas I Leaves; Gavin G Anderson; Chris P Ponting; John Broxholme; Richard Holt; Pauline Edser; Sumit Bhattacharyya; Andy Dunham; Ian M Adcock; Louise Pulleyn; Peter J Barnes; John I Harper; Goncalo Abecasis; Lon Cardon; Melanie White; John Burton; Lucy Matthews; Richard Mott; Mark Ross; Roger Cox; Miriam F Moffatt; William O C M Cookson
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.
Nature genetics 2003;34(2):181-6.
2003: Elodie Nabeyrat; Gina E Jones; Peter S Fenwick; Peter J Barnes; Louise E Donnelly
Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2003;284(6):L1112-20.
2003: Giovanna E Carpagnano; Peter J Barnes; Duncan M Geddes; Margaret E Hodson; Sergei A Kharitonov
Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis.
American journal of respiratory and critical care medicine 2003;167(8):1109-12.
2003: Giovanna E Carpagnano; Sergei A Kharitonov; Maria P Foschino Barbaro; Onofrio Resta; Enzo Gramiccioni; Peter J Barnes
Increased inflammatory markers in the exhaled breath condensate of cigarette smokers.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(4):589-93.
2003: Kai Michael Beeh; Oliver Kornmann; Roland Buhl; Sarah V Culpitt; Mark A Giembycz; Peter J Barnes
Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4.
Chest 2003;123(4):1240-7.
2003: Gaetano Caramori; Micaela Romagnoli; Paolo Casolari; Cinzia M Bellettato; Gianluca Casoni; Piera Boschetto; K Fan Chung; Peter J Barnes; Ian Adcock; Adalberto Ciaccia; Leonardo M Fabbri; Alberto Papi
Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations.
Thorax 2003;58(4):348-51.
2003: Wojciech A Biernacki; Sergei A Kharitonov; Peter J Barnes
Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD.
Thorax 2003;58(4):294-8.
2003: Martyn F Biddiscombe; Omar S Usmani; Peter J Barnes
A system for the production and delivery of monodisperse salbutamol aerosols to the lungs.
International journal of pharmaceutics 2003;254(2):243-53.
2003: Peter J Barnes
Theophylline: new perspectives for an old drug.
American journal of respiratory and critical care medicine 2003;167(6):813-8.
2003: Giovanna E Carpagnano; Sergei A Kharitonov; A U Wells; P Pantelidis; R M Du Bois; Peter J Barnes
Increased vitronectin and endothelin-1 in the breath condensate of patients with fibrosing lung disease.
Respiration; international review of thoracic diseases 2003;70(2):154-60.
2003: Paolo Paredi; Gaetano Caramori; Derek Cramer; S Ward; Adalberto Ciaccia; Alberto Papi; Sergei A Kharitonov; Peter J Barnes
Slower rise of exhaled breath temperature in chronic obstructive pulmonary disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(3):439-43.
2003: Sergei A Kharitonov; F Gonio; C Kelly; Sally Meah; Peter J Barnes
Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(3):433-8.
2003: Sergei A Kharitonov; Peter J Barnes
Nitric oxide, nitrotyrosine, and nitric oxide modulators in asthma and chronic obstructive pulmonary disease.
Current allergy and asthma reports 2003;3(2):121-9.
2003: Katsuyuki Tomita; Peter J Barnes; Ian M Adcock
The effect of oxidative stress on histone acetylation and IL-8 release.
Biochemical and biophysical research communications 2003;301(2):572-7.
2003: Paolo Montuschi; Enzo Ragazzoni; S Valente; Giuseppe Corbo; Chiara Mondino; Giuliano Ciappi; Peter J Barnes; Giovanni Ciabattoni
Validation of leukotriene B4 measurements in exhaled breath condensate.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(2):69-73.
2003: Susan J Smith; Steven Brookes-Fazakerley; Louise E Donnelly; Peter J Barnes; Mary S Barnette; Mark A Giembycz
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.
American journal of physiology. Lung cellular and molecular physiology 2003;284(2):L279-89.
2003: Peter J Barnes
New treatments for chronic obstructive pulmonary disease.
Annali dell'Istituto superiore di sanità 2003;39(4):573-82.
2003: Jeffrey C Hoyt; Richard A Robbins; Michael Habib; David R Springall; Lee D K Buttery; Julia M Polak; Peter J Barnes
Cigarette smoke decreases inducible nitric oxide synthase in lung epithelial cells.
Experimental lung research 2003;29(1):17-28.
2003: Peter J Barnes
Update on asthma.
The Israel Medical Association journal : IMAJ 2003;5(1):68-72.
2003: P Paredi; Sergei A Kharitonov; Peter J Barnes
Exhaled carbon monoxide in lung disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(1):197; author reply 197-8.
2003: P Paredi; Sergei A Kharitonov; Peter J Barnes
Exhaled breath temperature in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(1):195; author reply 196.
2003: T Wodehouse; Sergei A Kharitonov; Ian S Mackay; Peter J Barnes; Robert Wilson; Peter J Cole
Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(1):43-7.
2003: Ildikó Horváth; S Loukides; T Wodehouse; Eszter Csiszér; Peter J Cole; Sergei A Kharitonov; Peter J Barnes
Comparison of exhaled and nasal nitric oxide and exhaled carbon monoxide levels in bronchiectatic patients with and without primary ciliary dyskinesia.
Thorax 2003;58(1):68-72.
2003: MJ Leckie; G R Jenkins; J Khan; S J Smith; C Walker; Peter J Barnes; Trevor T Hansel
Sputum T lymphocytes in asthma, COPD and healthy subjects have the phenotype of activated intraepithelial T cells (CD69+ CD103+).
Thorax 2003;58(1):23-9.
2003: Peter J Barnes
Therapy of chronic obstructive pulmonary disease.
Pharmacology & therapeutics 2003;97(1):87-94.
2003: Sarah V Culpitt; Duncan F Rogers; Pallav Shah; C J S de Matos; Richard E K Russell; Louise E Donnelly; Peter J Barnes
Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2003;167(1):24-31.
2003: Peter J Barnes
New concepts in chronic obstructive pulmonary disease.
Annual review of medicine 2003;54():113-29.
2002: Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Analysis of expired air for oxidation products.
American journal of respiratory and critical care medicine 2002;166(12 Pt 2):S31-7.
2002: Paolo Montuschi; Julia A Nightingale; Sergei A Kharitonov; Peter J Barnes
Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
Free radical biology & medicine 2002;33(10):1403-8.
2002: Zsuzsanna Csoma; Sergei A Kharitonov; Beatrix Balint; Andrew Bush; Nicola M Wilson; Peter J Barnes
Increased leukotrienes in exhaled breath condensate in childhood asthma.
American journal of respiratory and critical care medicine 2002;166(10):1345-9.
2002: Waldo Mattos; Sam Lim; Richard Russell; Anon Jatakanon; K Fan Chung; Peter J Barnes
Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids.
Chest 2002;122(5):1543-52.
2002: Giovanna E Carpagnano; Sergei A Kharitonov; Onofrio Resta; Maria P Foschino Barbaro; Enzo Gramiccioni; Peter J Barnes
Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients.
Chest 2002;122(4):1162-7.
2002: Sergei A Kharitonov; Louise E Donnelly; Paolo Montuschi; Massimo Corradi; J V Collins; Peter J Barnes
Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma.
Thorax 2002;57(10):889-96.
2002: Richard E K Russell; Andrew Thorley; Sarah V Culpitt; Sara Dodd; Louise E Donnelly; Carmen Demattos; Mary Fitzgerald; Peter J Barnes
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.
American journal of physiology. Lung cellular and molecular physiology 2002;283(4):L867-73.
2002: PAUL EYNOTT; David A Groneberg; Gaetano Caramori; Ian M Adcock; Louise E Donnelly; Sergei A Kharitonov; Peter J Barnes; K Fan Chung
Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness.
European journal of pharmacology 2002;452(1):123-33.
2002: Trevor T Hansel; Peter J Barnes
Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD.
Drugs of today (Barcelona, Spain : 1998) 2002;38(9):585-600.
2002: A Emelyanov; G Fedoseev; O Krasnoschekova; A Abulimity; T Trendeleva; Peter J Barnes
Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;20(3):596-600.
2002: Antonino Di Stefano; Gaetano Caramori; Timothy Oates; Armando Capelli; Mirco Lusuardi; Isabelle Gnemmi; F Ioli; K Fan Chung; Claudio F Donner; Peter J Barnes; Ian M Adcock
Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;20(3):556-63.
2002: Katsuyuki Tomita; Gaetano Caramori; Sam Lim; Kazuhiro Ito; Toyoyuki Hanazawa; Timothy Oates; Irena Chiselita; Elen Jazrawi; K Fan Chung; Peter J Barnes; Ian M Adcock
Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers.
American journal of respiratory and critical care medicine 2002;166(5):724-31.
2002: K Fan Chung; Elizabeth L J van Rennen; Robert G Stirling; Peter J Barnes
Duplicate publication.
American journal of respiratory and critical care medicine 2002;166(4):625.
2002: Kazuhiro Ito; Gaetano Caramori; Sam Lim; Timothy Oates; K Fan Chung; Peter J Barnes; Ian M Adcock
Expression and activity of histone deacetylases in human asthmatic airways.
American journal of respiratory and critical care medicine 2002;166(3):392-6.
2002: Adam Antczak; Paolo Montuschi; Sergei A Kharitonov; Pawel Gorski; Peter J Barnes
Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma.
American journal of respiratory and critical care medicine 2002;166(3):301-6.
2002: K F Chung; E van Rensen; R Stirling; Peter J Barnes
IL-5 in asthma.
Thorax 2002;57(8):751.
2002: Suzanne L Traves; Sarah V Culpitt; Richard E K Russell; Peter J Barnes; Louise E Donnelly
Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD.
Thorax 2002;57(7):590-5.
2002: Kazuhiro Ito; Sam Lim; Gaetano Caramori; Borja Cosio; K Fan Chung; Ian M Adcock; Peter J Barnes
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8921-6.
2002: Shannon A Bryan; Peter J Jose; Joanna R Topping; Robert Wilhelm; Carol Soderberg; Denis Kertesz; Peter J Barnes; Timothy J Williams; Trevor T Hansel; Ian Sabroe
Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.
American journal of respiratory and critical care medicine 2002;165(12):1602-9.
2002: Edward M Erin; Timothy J Williams; Peter J Barnes; Trevor T Hansel
Eotaxin receptor (CCR3) antagonism in asthma and allergic disease.
Current drug targets. Inflammation and allergy 2002;1(2):201-14.
2002: Peter J Barnes
New treatments for COPD.
Nature reviews. Drug discovery 2002;1(6):437-46.
2002: Mark A Birrell; Natascia Crispino; David J Hele; Hema J Patel; Magdi H Yacoub; Peter J Barnes; Maria G Belvisi
Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD.
British journal of pharmacology 2002;136(4):620-8.
2002: Sarah V Culpitt; C J S de Matos; Richard E K Russell; Louise E Donnelly; Duncan F Rogers; Peter J Barnes
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2002;165(10):1371-6.
2002: Paolo Montuschi; Peter J Barnes
Analysis of exhaled breath condensate for monitoring airway inflammation.
Trends in pharmacological sciences 2002;23(5):232-7.
2002: Julia A Nightingale; Duncan F Rogers; Peter J Barnes
Comparison of the effects of salmeterol and formoterol in patients with severe asthma.
Chest 2002;121(5):1401-6.
2002: Edward M Erin; Peter J Barnes; Trevor T Hansel
Optimizing sputum methodology.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(5):653-7.
2002: Sukhbir K Shahid; Sergei A Kharitonov; Nicola M Wilson; Andrew Bush; Peter J Barnes
Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma.
American journal of respiratory and critical care medicine 2002;165(9):1290-3.
2002: Richard E K Russell; Sarah V Culpitt; Carmen DeMatos; Louise Donnelly; Michael Smith; John Wiggins; Peter J Barnes
Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease.
American journal of respiratory cell and molecular biology 2002;26(5):602-9.
2002: Patricia M De Souza; Hannu Kankaanranta; Ashour Michael; Peter J Barnes; Mark A Giembycz; Mark A Lindsay
Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis.
Blood 2002;99(9):3432-8.
2002: Elvis Irusen; John G Matthews; Atsushi Takahashi; Peter J Barnes; K Fan Chung; Ian M Adcock
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma.
The Journal of allergy and clinical immunology 2002;109(4):649-57.
2002: Paolo Montuschi; Peter J Barnes
Exhaled leukotrienes and prostaglandins in asthma.
The Journal of allergy and clinical immunology 2002;109(4):615-20.
2002: Franco Ravenna; Gaetano Caramori; G L Panella; Alberto Papi; G Benea; Ian Adcock; Peter J Barnes; Adalberto Ciaccia
An unusual case of congenital short trachea with very long bronchi mimicking bronchial asthma.
Thorax 2002;57(4):372-3.
2002: Alison A Hislop; Judith C W Mak; David Kelly; Jayne A Reader; Peter J Barnes; Sheila G Haworth
Postnatal changes in beta-adrenoceptors in the lung and the effect of hypoxia induced pulmonary hypertension of the newborn.
British journal of pharmacology 2002;135(6):1415-24.
2002: Trevor T Hansel; Peter J Sterk; Stephen T Holgate; Peter J Barnes
The trials and tribulations of anti-IL-5 em leader.
The Journal of allergy and clinical immunology 2002;109(3):575-6.
2002: Katsuyuki Tomita; Sam Lim; Toyoyuki Hanazawa; Omar S Usmani; Robert G Stirling; K Fan Chung; Peter J Barnes; Ian M Adcock
Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma.
Clinical immunology (Orlando, Fla.) 2002;102(3):258-66.
2002: Judith C W Mak; Tsu Tshen Chuang; Carol A Harris; Peter J Barnes
Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung.
European journal of pharmacology 2002;436(3):165-72.
2002: Trevor T Hansel; Edward M Erin; Peter J Barnes
The allergen challenge.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(2):162-7.
2002: Judith C W Mak; Takeshi Hisada; Michael Salmon; Peter J Barnes; K Fan Chung
Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases.
British journal of pharmacology 2002;135(4):987-96.
2002: Peter J Barnes
The role of inflammation and anti-inflammatory medication in asthma.
Respiratory medicine 2002;96 Suppl A():S9-15.
2002: Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Faster rise of exhaled breath temperature in asthma: a novel marker of airway inflammation?
American journal of respiratory and critical care medicine 2002;165(2):181-4.
2002: Peter J Barnes
Advances in chronic obstructive pulmonary disease.
Transactions of the Medical Society of London 2002;119():41-51.
2002: Peter J Barnes
Current and future therapies for airway mucus hypersecretion.
Novartis Foundation symposium 2002;248():237-49; discussion 249-53, 277-82.
2002: Peter J Barnes
Glucocorticoids and asthma.
Ernst Schering Research Foundation workshop 2002;(40):1-23.
2002: Sergei A Kharitonov; Peter J Barnes
Biomarkers of some pulmonary diseases in exhaled breath.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2002;7(1):1-32.
2002: Hannu Kankaanranta; Mark A Giembycz; Peter J Barnes; El-Bdaoui Haddad; Seppo Saarelainen; Xianzhi Zhang; Eeva Moilanen; Mark A Lindsay
Hydrogen peroxide reverses IL-5 afforded eosinophil survival and promotes constitutive human eosinophil apoptosis.
International archives of allergy and immunology 2002;127(1):73-8.
2002: Peter J Barnes
Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(1):182-91.
2002: David A Groneberg; PAUL EYNOTT; F Döring; Q Thai Dinh; Timothy Oates; Peter J Barnes; K Fan Chung; Hannelore Daniel; A Fischer
Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung.
Thorax 2002;57(1):55-60.
2002: Peter J Barnes
Cytokine modulators as novel therapies for asthma.
Annual review of pharmacology and toxicology 2002;42():81-98.
2002: Louise E Donnelly; Peter J Barnes
Expression and regulation of inducible nitric oxide synthase from human primary airway epithelial cells.
American journal of respiratory cell and molecular biology 2002;26(1):144-51.
2001: Peter J Barnes
Cytokine modulators as novel therapies for airway disease.
The European respiratory journal. Supplement 2001;34():67s-77s.
2001: Peter J Barnes
Cytokine modulators for allergic diseases.
Current opinion in allergy and clinical immunology 2001;1(6):555-60.
2001: Peter J Barnes
Molecular mechanisms of atopy.
Mediators of inflammation 2001;10(6):285-8.
2001: L J Pulleyn; R Newton; I M Adcock; Peter J Barnes
TGFbeta1 allele association with asthma severity.
Human genetics 2001;109(6):623-7.
2001: Wojciech A Biernacki; Sergei A Kharitonov; Peter J Barnes
Exhaled carbon monoxide in patients with lower respiratory tract infection.
Respiratory medicine 2001;95(12):1003-5.
2001: E L van Rensen; Robert G Stirling; J Scheerens; Karl J Staples; P J Sterk; Peter J Barnes; K Fan Chung
Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma.
Thorax 2001;56(12):935-40.
2001: B Oliver; K Tomita; A Keller; Gaetano Caramori; I Adcock; K F Chung; Peter J Barnes; S Lim
Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages.
Allergy 2001;56(11):1087-90.
2001: Masahiko Kagoshima; T Wilcke; Kazuhiro Ito; Loukia Tsaprouni; Peter J Barnes; Neville A Punchard; Ian M Adcock
Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation.
European journal of pharmacology 2001;429(1-3):327-34.
2001: Robert G Stirling; E L van Rensen; Peter J Barnes; K Fan Chung
Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma.
American journal of respiratory and critical care medicine 2001;164(8 Pt 1):1403-9.
2001: Paul M O'Byrne; Peter J Barnes; R Rodriguez-Roisin; E Runnerstrom; T Sandstrom; Klas Svensson; Anne E Tattersfield
Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial.
American journal of respiratory and critical care medicine 2001;164(8 Pt 1):1392-7.
2001: OT Lynch; Mark A Giembycz; Peter J Barnes; Mark A Lindsay
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
British journal of pharmacology 2001;134(4):797-806.
2001: A Emelyanov; G Fedoseev; A Abulimity; K Rudinski; A Fedoulov; A Karabanov; Peter J Barnes
Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients.
Chest 2001;120(4):1136-9.
2001: Peter J Barnes
Molecular mechanisms of corticosteroids in allergic diseases.
Allergy 2001;56(10):928-36.
2001: Robert Newton; Karl J Staples; L Hart; Peter J Barnes; Martin W Bergmann
GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms.
Biochemical and biophysical research communications 2001;287(1):249-53.
2001: Gaetano Caramori; Sam Lim; Kazuhiro Ito; Katsuyuki Tomita; Timothy Oates; Elen Jazrawi; K Fan Chung; Peter J Barnes; Ian M Adcock
Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(3):466-73.
2001: Sergei A Kharitonov; Peter J Barnes
Does exhaled nitric oxide reflect asthma control? Yes, it does!
American journal of respiratory and critical care medicine 2001;164(5):727-8.
2001: Karl J Staples; M Bergmann; K Tomita; Miles D Houslay; I McPhee; Peter J Barnes; Mark A Giembycz; Robert Newton
Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2074-80.
2001: Kazuhiro Ito; Elen Jazrawi; Borja Cosio; Peter J Barnes; Ian M Adcock
p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex.
The Journal of biological chemistry 2001;276(32):30208-15.
2001: Peter J Barnes
Clinical outcome of adding long-acting beta-agonists to inhaled corticosteroids.
Respiratory medicine 2001;95 Suppl B():S12-6.
2001: Ildikó Horváth; W MacNee; Frank Kelly; P N Dekhuijzen; M Phillips; G Döring; A M Choi; M Yamaya; F H Bach; D Willis; Louise E Donnelly; K F Chung; Peter J Barnes
"Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(2):420-30.
2001: Paolo Montuschi; Sergei A Kharitonov; Peter J Barnes
Exhaled carbon monoxide and nitric oxide in COPD.
Chest 2001;120(2):496-501.
2001: Peter J Barnes
Cytokine-directed therapies for asthma.
The Journal of allergy and clinical immunology 2001;108(2 Suppl):S72-6.
2001: Lucia Spicuzza; Maria G Belvisi; Mark A Birrell; Peter J Barnes; David J Hele; Mark A Giembycz
Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase.
British journal of pharmacology 2001;133(8):1201-12.
2001: A J Fox; Hema J Patel; Peter J Barnes; M G Belvisi
Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases.
European journal of pharmacology 2001;424(2):159-62.
2001: Sam Lim; Katsuyuki Tomita; Gaetano Caramori; Anon Jatakanon; B Oliver; A Keller; Ian M Adcock; K Fan Chung; Peter J Barnes; G Carramori
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma.
American journal of respiratory and critical care medicine 2001;164(2):273-6.
2001: Douglas S Robinson; D Campbell; Peter J Barnes
Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial.
Lancet 2001;357(9273):2007-11.
2001: Sergei A Kharitonov; Peter J Barnes
Exhaled markers of inflammation.
Current opinion in allergy and clinical immunology 2001;1(3):217-24.
2001: Peter J Barnes
New treatments for chronic obstructive pulmonary disease.
Current opinion in pharmacology 2001;1(3):217-22.
2001: B Balint; Sergei A Kharitonov; Toyoyuki Hanazawa; Louise E Donnelly; Pallav L Shah; Margaret E Hodson; Peter J Barnes
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(6):1201-7.
2001: Antonino Di Stefano; Armando Capelli; Mirco Lusuardi; Gaetano Caramori; P Balbo; F Ioli; S Sacco; Isabelle Gnemmi; P Brun; Ian M Adcock; Bruno Balbi; Peter J Barnes; K Fan Chung; Claudio F Donner
Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(6):893-902.
2001: Fredrik L Andersson; E Stahl; Peter J Barnes; Claes-Göran AH Löfdahl; Paul M O'Byrne; Romain A Pauwels; Dirkje S Postma; Anne E Tattersfield; Anders Ullman
Adding formoterol to budesonide in moderate asthma--health economic results from the FACET study.
Respiratory medicine 2001;95(6):505-12.
2001: Sergei A Kharitonov; Peter J Barnes
Exhaled markers of pulmonary disease.
American journal of respiratory and critical care medicine 2001;163(7):1693-722.
2001: B Balint; Louise E Donnelly; Toyoyuki Hanazawa; Sergei A Kharitonov; Peter J Barnes
Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke.
Thorax 2001;56(6):456-61.
2001: Peter J Barnes
IL-10: a key regulator of allergic disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(5):667-9.
2001: K Fujita; Soji Kasayama; J Hashimoto; Y Nagasaka; N Nakano; Y Morimoto; Peter J Barnes; Akihiko Miyatake
Inhaled corticosteroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):782-7.
2001: Kazuhiro Ito; Sam Lim; Gaetano Caramori; K Fan Chung; Peter J Barnes; Ian M Adcock
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1110-2.
2001: Peter J Barnes
Tiotropium bromide.
Expert opinion on investigational drugs 2001;10(4):733-40.
2001: Lucia Spicuzza; Peter J Barnes; Giuseppe U Di Maria; Maria G Belvisi
Effect of 8-iso-prostaglandin F(2 alpha) on acetylcholine release from parasympathetic nerves in guinea pig airways.
European journal of pharmacology 2001;416(3):231-4.
2001: Trevor T Hansel; Peter J Barnes
Novel drugs for treating asthma.
Current allergy and asthma reports 2001;1(2):164-73.
2001: JL Pype; Haiyan Xu; Marleen Schuermans; Lieven J Dupont; Wim A Wuyts; JC Mak; Peter J Barnes; Maurits G Demedts; Geert M Verleden
Mechanisms of interleukin 1beta-induced human airway smooth muscle hyporesponsiveness to histamine. Involvement of p38 MAPK NF-kappaB.
American journal of respiratory and critical care medicine 2001;163(4):1010-7.
2001: Massimo Corradi; Paolo Montuschi; Louise E Donnelly; Alberto Pesci; Sergei A Kharitonov; Peter J Barnes
Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases.
American journal of respiratory and critical care medicine 2001;163(4):854-8.
2001: PA Finney; Louise E Donnelly; Maria G Belvisi; Tsu Tshen Chuang; Mark A Birrell; A Harris; Judith C W Mak; CA Scorer; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha).
British journal of pharmacology 2001;132(6):1261-70.
2001: Louise E Donnelly; Peter J Barnes
Expression of heme oxygenase in human airway epithelial cells.
American journal of respiratory cell and molecular biology 2001;24(3):295-303.
2001: Peter J Barnes
Neurogenic inflammation in the airways.
Respiration physiology 2001;125(1-2):145-54.
2001: Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Direct methods for the measurement of nitric oxide.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 2001;56(1):88-90.
2001: Peter J Barnes
Corticosteroids, IgE, and atopy.
The Journal of clinical investigation 2001;107(3):265-6.
2001: Shannon A Bryan; MJ Leckie; G Jenkins; Peter J Barnes; Timothy J Williams; Ian Sabroe; Trevor T Hansel
Measurement of granulocyte pharmacodynamics in whole blood by flow cytometry.
Methods in molecular medicine 2001;56():345-55.
2001: Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Measurement of exhaled hydrocarbons.
Methods in molecular medicine 2001;56():109-18.
2001: Peter J Barnes
Future Advances in COPD Therapy.
Respiration; international review of thoracic diseases 2001;68(5):441-8.
2001: Peter J Barnes
Th2 cytokines and asthma: an introduction.
Respiratory research 2001;2(2):64-5.
2001: Peter J Barnes
Histamine and serotonin.
Pulmonary pharmacology & therapeutics 2001;14(5):329-39.
2001: Peter J Barnes
Potential novel therapies for chronic obstructive pulmonary disease.
Novartis Foundation symposium 2001;234():255-67; discussion 267-72.
2001: Paolo Paredi; Sergei A Kharitonov; Toyoyuki Hanazawa; Peter J Barnes
Local vasodilator response to mobile phones.
The Laryngoscope 2001;111(1):159-62.
2001: Peter J Barnes; C Page
Mediators of asthma: a new series.
Pulmonary pharmacology & therapeutics 2001;14(1):1-2.
2000: Shannon A Bryan; Brian J O'connor; S Matti; MJ Leckie; Varsha Kanabar; J Khan; Steve Warrington; L Renzetti; A Rames; J A Bock; Malcolm Boyce; Trevor T Hansel; Stephen T Holgate; Peter J Barnes
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000;356(9248):2149-53.
2000: MJ Leckie; A ten Brinke; J Khan; Z Diamant; Brian J O'connor; C M Walls; A K Mathur; H C Cowley; K Fan Chung; R Djukanovic; Trevor T Hansel; Stephen T Holgate; P J Sterk; Peter J Barnes
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000;356(9248):2144-8.
2000: Judith C W Mak; J Rousell; EB Haddad; Peter J Barnes
Transforming growth factor-beta1 inhibits beta2-adrenoceptor gene transcription.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(6):520-5.
2000: Robert Newton; L Hart; K F Chung; Peter J Barnes
Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB.
Biochemical and biophysical research communications 2000;277(3):675-9.
2000: H S Sandhu; Peter J Barnes; Paul Hernandez
Hydroxyurea-induced hypersensitivity pneumonitis: A case report and literature review.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2000;7(6):491-5.
2000: Peter J Barnes
Anti-IgE therapy in asthma: rationale and therapeutic potential.
International archives of allergy and immunology 2000;123(3):196-204.
2000: koremu meja; Paul M Seldon; Yasuyuki Nasuhara; Kazuhiro Ito; Peter J Barnes; Mark A Lindsay; Mark A Giembycz
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism.
British journal of pharmacology 2000;131(6):1143-53.
2000: Sam Lim; David A Groneberg; A Fischer; Timothy Oates; Gaetano Caramori; Waldo Mattos; Ian M Adcock; Peter J Barnes; K Fan Chung
Expression of heme oxygenase isoenzymes 1 and 2 in normal and asthmatic airways: effect of inhaled corticosteroids.
American journal of respiratory and critical care medicine 2000;162(5):1912-8.
2000: A Koch; Yasuyuki Nasuhara; Peter J Barnes; Mark A Lindsay; Mark A Giembycz
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
British journal of pharmacology 2000;131(5):981-9.
2000: Sergei A Kharitonov; Peter J Barnes
Clinical aspects of exhaled nitric oxide.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(4):781-92.
2000: Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Elevation of exhaled ethane concentration in asthma.
American journal of respiratory and critical care medicine 2000;162(4 Pt 1):1450-4.
2000: Sam Lim; Nicolas Roche; Brian G Oliver; Waldo Mattos; Peter J Barnes; K Fan Chung
Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10.
American journal of respiratory and critical care medicine 2000;162(4 Pt 1):1355-60.
2000: Toyoyuki Hanazawa; Sergei A Kharitonov; Peter J Barnes
Increased nitrotyrosine in exhaled breath condensate of patients with asthma.
American journal of respiratory and critical care medicine 2000;162(4 Pt 1):1273-6.
2000: Sam Lim; A Jatakanon; D Gordon; C Macdonald; K Fan Chung; Peter J Barnes
Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice.
Thorax 2000;55(10):837-41.
2000: Paolo Montuschi; J V Collins; Giovanni Ciabattoni; N Lazzeri; Massimo Corradi; Sergei A Kharitonov; Peter J Barnes
Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers.
American journal of respiratory and critical care medicine 2000;162(3 Pt 1):1175-7.
2000: Kazuhiro Ito; Peter J Barnes; Ian M Adcock
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.
Molecular and cellular biology 2000;20(18):6891-903.
2000: C Byrnes; S Shrewsbury; Peter J Barnes; A Bush
Salmeterol in paediatric asthma.
Thorax 2000;55(9):780-4.
2000: Paolo Paredi; Sergei A Kharitonov; D Leak; Simon Ward; Derek Cramer; Peter J Barnes
Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):369-73.
2000: Lucia Spicuzza; EB Haddad; Mark A Birrell; A Ling; D Clarke; P Venkatesan; Peter J Barnes; Maria G Belvisi
Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves.
British journal of pharmacology 2000;130(7):1720-6.
2000: Peter J Barnes
Chronic obstructive pulmonary disease.
The New England journal of medicine 2000;343(4):269-80.
2000: Karl J Staples; M Bergmann; Peter J Barnes; Robert Newton
Stimulus-specific inhibition of IL-5 by cAMP-elevating agents and IL-10 reveals differential mechanisms of action.
Biochemical and biophysical research communications 2000;273(3):811-5.
2000: Robert Newton; Lisa M Cambridge; LA Hart; DA Stevens; Mark A Lindsay; Peter J Barnes
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
British journal of pharmacology 2000;130(6):1353-61.
2000: Julia A Nightingale; R Maggs; P Cullinan; Louise E Donnelly; Duncan F Rogers; R Kinnersley; K Fan Chung; Peter J Barnes; M Ashmore; A Newman-Taylor
Airway inflammation after controlled exposure to diesel exhaust particulates.
American journal of respiratory and critical care medicine 2000;162(1):161-6.
2000: Toshio Katsunuma; K Fujita; Judith C W Mak; Peter J Barnes; K Ueno; Yoji Iikura
Beta-adrenergic agonists and bronchial hyperreactivity: role of beta2-adrenergic and tachykinin neurokinin-2 receptors.
The Journal of allergy and clinical immunology 2000;106(1 Pt 2):S104-8.
2000: Hannu Kankaanranta; Mark A Lindsay; Mark A Giembycz; X Zhang; E Moilanen; Peter J Barnes
Delayed eosinophil apoptosis in asthma.
The Journal of allergy and clinical immunology 2000;106(1 Pt 1):77-83.
2000: Peter J Barnes
New directions in allergic diseases: mechanism-based anti-inflammatory therapies.
The Journal of allergy and clinical immunology 2000;106(1 Pt 1):5-16.
2000: PA Finney; Maria G Belvisi; Louise E Donnelly; Tsu Tshen Chuang; Judith C W Mak; CA Scorer; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo.
The Journal of clinical investigation 2000;106(1):125-35.
2000: Hardeep K Ranu; Judith C W Mak; Peter J Barnes; Sian E Harding
G(i)-dependent suppression of beta(1)-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1807-14.
2000: OT Lynch; Mark A Giembycz; I Daniels; Peter J Barnes; Mark A Lindsay
Pleiotropic role of lyn kinase in leukotriene B(4)-induced eosinophil activation.
Blood 2000;95(11):3541-7.
2000: EB Haddad; Alison J Fox; J Rousell; G Burgess; P McIntyre; Peter J Barnes; K Fan Chung
Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone.
Molecular pharmacology 2000;57(6):1123-31.
2000: MJ Leckie; Shannon A Bryan; J Khan; A Dewar; S L Aikman; J McGrath; D A Okrongly; John F Burman; Peter J Barnes; Trevor T Hansel
Automated quantitation of circulating neutrophil and eosinophil activation in asthmatic patients.
Thorax 2000;55(6):471-7.
2000: S M Dennis; S J Sharp; Margaret Rose Vickers; C D Frost; G K Crompton; Peter J Barnes; T H Lee
Regular inhaled salbutamol and asthma control: the TRUST randomised trial. Therapy Working Group of the National Asthma Task Force and the MRC General Practice Research Framework.
Lancet 2000;355(9216):1675-9.
2000: Sam Lim; M John; J Seybold; D Taylor; C Witt; Peter J Barnes; K Fan Chung
Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma.
Allergy 2000;55(5):489-95.
2000: M Bergmann; Peter J Barnes; R Newton
Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1beta, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms.
American journal of respiratory cell and molecular biology 2000;22(5):582-9.
2000: Judith C W Mak; AF Roffel; Toshio Katsunuma; Carolina R S Elzinga; Johan Zaagsma; Peter J Barnes
Up-regulation of airway smooth muscle histamine H(1) receptor mRNA, protein, and function by beta(2)-adrenoceptor activation.
Molecular pharmacology 2000;57(5):857-64.
2000: S R Thomas; Sergei A Kharitonov; SF Scott; Margaret E Hodson; Peter J Barnes
Nasal and exhaled nitric oxide is reduced in adult patients with cystic fibrosis and does not correlate with cystic fibrosis genotype.
Chest 2000;117(4):1085-9.
2000: Paolo Paredi; Sergei A Kharitonov; D Leak; Pallav L Shah; Derek Cramer; Margaret E Hodson; Peter J Barnes
Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction.
American journal of respiratory and critical care medicine 2000;161(4 Pt 1):1247-51.
2000: Peter J Barnes
Nonantimicrobial aspects of therapy.
Seminars in respiratory infections 2000;15(1):52-8.
2000: Peter J Barnes
Endogenous inhibitory mechanisms in asthma.
American journal of respiratory and critical care medicine 2000;161(3 Pt 2):S176-81.
2000: Paolo Montuschi; Sergei A Kharitonov; Giovanni Ciabattoni; Massimo Corradi; L van Rensen; D M Geddes; M E Hodson; Peter J Barnes
Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
Thorax 2000;55(3):205-9.
2000: Sam Lim; Anon Jatakanon; S Meah; Timothy Oates; K Fan Chung; Peter J Barnes
Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma.
Thorax 2000;55(3):184-8.
2000: Peter J Barnes
The pharmacological properties of tiotropium.
Chest 2000;117(2 Suppl):63S-6S.
2000: Peter J Barnes
Mechanisms in COPD: differences from asthma.
Chest 2000;117(2 Suppl):10S-4S.
2000: Rame Taha; Ron Olivenstein; T Utsumi; Pierre Ernst; Peter J Barnes; Ian W Rodger; Adel Giaid
Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):636-40.
2000: Julia A Nightingale; Duncan F Rogers; K Fan Chung; Peter J Barnes
No effect of inhaled budesonide on the response to inhaled ozone in normal subjects.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):479-86.
2000: Peter J Barnes
Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):342-4; discussioin 344.
2000: J D Antuni; Sergei A Kharitonov; D Hughes; Margaret E Hodson; Peter J Barnes
Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis.
Thorax 2000;55(2):138-42.
2000: Peter J Barnes
Molecular basis for corticosteroid action in asthma.
Chemical immunology 2000;78():72-80.
2000: Shannon A Bryan; MJ Leckie; Trevor T Hansel; Peter J Barnes
Novel therapy for asthma.
Expert opinion on investigational drugs 2000;9(1):25-42.
2000: MJ Leckie; Shannon A Bryan; Trevor T Hansel; Peter J Barnes
Novel therapy for COPD.
Expert opinion on investigational drugs 2000;9(1):3-23.
2000: Toyoyuki Hanazawa; J D Antuni; Sergei A Kharitonov; Peter J Barnes
Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis.
The Journal of allergy and clinical immunology 2000;105(1 Pt 1):58-64.
2000: L Hart; Sam Lim; Ian M Adcock; Peter J Barnes; K Fan Chung
Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma.
American journal of respiratory and critical care medicine 2000;161(1):224-31.
2000: Anon Jatakanon; Sam Lim; Peter J Barnes
Changes in sputum eosinophils predict loss of asthma control.
American journal of respiratory and critical care medicine 2000;161(1):64-72.
1999: Peter J Barnes
Anti-IgE antibody therapy for asthma.
The New England journal of medicine 1999;341(26):2006-8.
1999: Julia A Nightingale; Duncan F Rogers; Peter J Barnes
Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects.
Thorax 1999;54(12):1061-9.
1999: Peter J Barnes
Therapeutic strategies for allergic diseases.
Nature 1999;402(6760 Suppl):B31-8.
1999: Elizabeth F Juniper; Klas Svensson; Paul M O'Byrne; Peter J Barnes; C A Bauer; Claes-Göran AH Löfdahl; Dirkje S Postma; Romain A Pauwels; Anne E Tattersfield; Anders Ullman
Asthma quality of life during 1 year of treatment with budesonide with or without formoterol.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(5):1038-43.
1999: Sergei A Kharitonov; M M Sapienza; K Fan Chung; Peter J Barnes
Prostaglandins mediate bradykinin-induced reduction of exhaled nitric oxide in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(5):1023-7.
1999: OT Lynch; Mark A Giembycz; Peter J Barnes; Paul G Hellewell; Mark A Lindsay
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
British journal of pharmacology 1999;128(6):1149-58.
1999: Peter J Barnes
Novel approaches and targets for treatment of chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1999;160(5 Pt 2):S72-9.
1999: Sarah V Culpitt; Wasim Maziak; S Loukidis; Julia A Nightingale; J L Matthews; Peter J Barnes
Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1635-9.
1999: Anon Jatakanon; CG Uasuf; Wasim Maziak; Sam Lim; K Fan Chung; Peter J Barnes
Neutrophilic inflammation in severe persistent asthma.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1532-9.
1999: CG Uasuf; Anon Jatakanon; A James; Sergei A Kharitonov; Nicola M Wilson; Peter J Barnes
Exhaled carbon monoxide in childhood asthma.
The Journal of pediatrics 1999;135(5):569-74.
1999: T Flüge; Wolf-Georg Forssmann; G Kunkel; B Schneider; P Mentz; Kristin Forssmann; Peter J Barnes; M Meyer
Bronchodilation using combined urodilatin - albuterol administration in asthma: a randomized, double-blind, placebo-controlled trial.
European journal of medical research 1999;4(10):411-5.
1999: Paolo Paredi; Wojciech A Biernacki; Giovanni Invernizzi; Sergei A Kharitonov; Peter J Barnes
Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood: a new test for monitoring the disease?
Chest 1999;116(4):1007-11.
1999: Paolo Paredi; Pallav L Shah; Paolo Montuschi; P Sullivan; Margaret E Hodson; Sergei A Kharitonov; Peter J Barnes
Increased carbon monoxide in exhaled air of patients with cystic fibrosis.
Thorax 1999;54(10):917-20.
1999: Michael Salmon; D A Walsh; H Koto; Peter J Barnes; K Fan Chung
Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(3):633-41.
1999: Duncan F Rogers; Peter J Barnes
COPD: new developments and therapeutic opportunities.
Trends in pharmacological sciences 1999;20(9):352-4.
1999: M M Bernareggi; Maria G Belvisi; H Patel; Peter J Barnes; Mark A Giembycz
Anti-spasmogenic activity of isoenzyme-selective phosphodiesterase inhibitors in guinea-pig trachealis.
British journal of pharmacology 1999;128(2):327-36.
1999: I Horváth; Peter J Barnes
Exhaled monoxides in asymptomatic atopic subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(9):1276-80.
1999: Toshio Katsunuma; AF Roffel; Carolina R S Elzinga; Johan Zaagsma; Peter J Barnes; Judith C W Mak
beta(2)-adrenoceptor agonist-induced upregulation of tachykinin NK(2) receptor expression and function in airway smooth muscle.
American journal of respiratory cell and molecular biology 1999;21(3):409-17.
1999: K Fan Chung; Peter J Barnes
Cytokines in asthma.
Thorax 1999;54(9):825-57.
1999: Peter J Barnes
Effect of beta-agonists on inflammatory cells.
The Journal of allergy and clinical immunology 1999;104(2 Pt 2):S10-7.
1999: D J Evans; Mark A Lindsay; BL Webb; Hannu Kankaanranta; Mark A Giembycz; Brian J O'connor; Peter J Barnes
Expression and activation of protein kinase C-zeta in eosinophils after allergen challenge.
The American journal of physiology 1999;277(2 Pt 1):L233-9.
1999: Anne E Tattersfield; Dirkje S Postma; Peter J Barnes; Klas Svensson; C A Bauer; Paul M O'Byrne; Claes-Göran AH Löfdahl; Romain A Pauwels; Anders Ullman
Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group.
American journal of respiratory and critical care medicine 1999;160(2):594-9.
1999: Hannu Kankaanranta; Patricia M De Souza; Peter J Barnes; Michael Salmon; Mark A Giembycz; Mark A Lindsay
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils.
The Journal of pharmacology and experimental therapeutics 1999;290(2):621-8.
1999: Takeshi Hisada; Ian M Adcock; Yasuyuki Nasuhara; Michael Salmon; Tung-Jung Huang; Peter J Barnes; K Fan Chung
Inhibition of ozone-induced lung neutrophilia and nuclear factor-kappaB binding activity by vitamin A in rat.
European journal of pharmacology 1999;377(1):63-8.
1999: Yasuyuki Nasuhara; Ian M Adcock; Matthew C Catley; Peter J Barnes; Robert Newton
Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription.
The Journal of biological chemistry 1999;274(28):19965-72.
1999: Michael Salmon; D A Walsh; Tung-Jung Huang; Peter J Barnes; T B Leonard; Douglas W P Hay; K Fan Chung
Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats.
British journal of pharmacology 1999;127(5):1151-8.
1999: DA Taylor; Marianne W Jensen; Varsha Kanabar; Renate Engelstätter; VW Steinijans; Peter J Barnes; Brian J O'connor
A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5'-monophosphate in asthmatic patients.
American journal of respiratory and critical care medicine 1999;160(1):237-43.
1999: Paolo Montuschi; Massimo Corradi; Giovanni Ciabattoni; Julia A Nightingale; Sergei A Kharitonov; Peter J Barnes
Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients.
American journal of respiratory and critical care medicine 1999;160(1):216-20.
1999: Hema J Patel; P Venkatesan; J Halfpenny; Magdi H Yacoub; A Fox; Peter J Barnes; Maria G Belvisi
Modulation of acetylcholine release from parasympathetic nerves innervating guinea-pig and human trachea by endomorphin-1 and -2.
European journal of pharmacology 1999;374(1):21-4.
1999: Ian M Adcock; Y Nasuhara; D A Stevens; Peter J Barnes
Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.
British journal of pharmacology 1999;127(4):1003-11.
1999: Paul S Thomas; Deborah H Yates; Peter J Barnes
Sputum induction as a method of analyzing pulmonary cells: reproducibility and acceptability.
The Journal of asthma : official journal of the Association for the Care of Asthma 1999;36(4):335-41.
1999: Julia A Nightingale; Duncan F Rogers; Peter J Barnes
Differential effect of formoterol on adenosine monophosphate and histamine reactivity in asthma.
American journal of respiratory and critical care medicine 1999;159(6):1786-90.
1999: Robert J Hancox; D A Stevens; I M Adcock; Peter J Barnes; D Robin Taylor
Effects of inhaled beta agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthma.
Thorax 1999;54(6):488-92.
1999: K Fan Chung; P Godard; E Adelroth; J Ayres; N Barnes; Peter J Barnes; E Bel; Peter Burney; P Chanez; G Connett; C Corrigan; J de Blic; L Fabbri; Stephen T Holgate; Philip W Ind; G Joos; Huib A M Kerstjens; P Leuenberger; C G Lofdahl; S McKenzie; Helgo Magnussen; Dirkje S Postma; Marina Saetta; S Salmeron; P Sterk
Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(5):1198-208.
1999: EB Haddad; H Patel; J E Keeling; Magdi H Yacoub; Peter J Barnes; Maria G Belvisi
Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea-pig airways.
British journal of pharmacology 1999;127(2):413-20.
1999: Paolo Paredi; Sergei A Kharitonov; S Loukides; P Pantelidis; Roland M Du Bois; Peter J Barnes
Exhaled nitric oxide is increased in active fibrosing alveolitis.
Chest 1999;115(5):1352-6.
1999: Paul S Thomas; Duncan M Geddes; Peter J Barnes
Pseudo-steroid resistant asthma.
Thorax 1999;54(4):352-6.
1999: Peter J Barnes
Genetics and pulmonary medicine. 9. Molecular genetics of chronic obstructive pulmonary disease.
Thorax 1999;54(3):245-52.
1999: Anon Jatakanon; U G Lalloo; Sam Lim; K Fan Chung; Peter J Barnes
Increased neutrophils and cytokines, TNF-alpha and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough.
Thorax 1999;54(3):234-7.
1999: MA Saunders; M G Belvisi; G Cirino; Peter J Barnes; T D Warner; Jane A Mitchell
Mechanisms of prostaglandin E2 release by intact cells expressing cyclooxygenase-2: evidence for a 'two-component' model.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1101-6.
1999: Anon Jatakanon; Sergei A Kharitonov; Sam Lim; Peter J Barnes
Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma.
Thorax 1999;54(2):108-14.
1999: M Fuhrmann; Hans-Ulrich Jahn; Joachim Seybold; C Neurohr; Peter J Barnes; Stefan Hippenstiel; H J Kraemer; Norbert Suttorp
Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells.
American journal of respiratory cell and molecular biology 1999;20(2):292-302.
1999: Paolo Paredi; MJ Leckie; I Horvath; Luigi Allegra; Sergei A Kharitonov; Peter J Barnes
Changes in exhaled carbon monoxide and nitric oxide levels following allergen challenge in patients with asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(1):48-52.
1999: A Emelyanov; G Fedoseev; Peter J Barnes
Reduced intracellular magnesium concentrations in asthmatic patients.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(1):38-40.
1999: Hema J Patel; GJ Douglas; CM Herd; Domenico Spina; Mark A Giembycz; Peter J Barnes; Maria G Belvisi; Clive P Page
Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M(2)-receptor dysfunction.
Pulmonary pharmacology & therapeutics 1999;12(4):245-55.
1999: Peter J Barnes
Strategies for novel COPD therapies.
Pulmonary pharmacology & therapeutics 1999;12(2):67-71.
1999: S E Hall; Sam Lim; Ian R Witherden; Teresa D Tetley; Peter J Barnes; Ahmad M Kamal; SF Smith
Lung type II cell and macrophage annexin I release: differential effects of two glucocorticoids.
The American journal of physiology 1999;276(1 Pt 1):L114-21.
1999: Sam Lim; Anon Jatakanon; M John; T Gilbey; Brian J O'connor; K Fan Chung; Peter J Barnes
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma.
American journal of respiratory and critical care medicine 1999;159(1):22-30.
1998: SJ Lane; I M Adcock; David Richards; Catherine M Hawrylowicz; Peter J Barnes; Tak H Lee
Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes.
The Journal of clinical investigation 1998;102(12):2156-64.
1998: R G Stirling; Sergei A Kharitonov; D Campbell; D S Robinson; Stephen R Durham; K Fan Chung; Peter J Barnes
Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids. Asthma and Allergy Group.
Thorax 1998;53(12):1030-4.
1998: JL Pype; JC Mak; Lieven J Dupont; Geert M Verleden; Peter J Barnes
Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle.
British journal of pharmacology 1998;125(7):1477-84.
1998: Peter J Barnes; K F Chung; C P Page
Inflammatory mediators of asthma: an update.
Pharmacological reviews 1998;50(4):515-96.
1998: RB Dowling; Robert Newton; A Robichaud; Peter J Cole; Peter J Barnes; Robert Wilson
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro.
American journal of respiratory cell and molecular biology 1998;19(6):950-8.
1998: Robert Newton; J Seybold; LM Kuitert; M Bergmann; Peter J Barnes
Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA.
The Journal of biological chemistry 1998;273(48):32312-21.
1998: Peter J Barnes; A J Woolcock
Difficult asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(5):1209-18.
1998: Anon Jatakanon; Sam Lim; K Fan Chung; Peter J Barnes
An inhaled steroid improves markers of airway inflammation in patients with mild asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(5):1084-8.
1998: Peter J Barnes
Pharmacology of airway smooth muscle.
American journal of respiratory and critical care medicine 1998;158(5 Pt 3):S123-32.
1998: LA Hart; V L Krishnan; Ian M Adcock; Peter J Barnes; K Fan Chung
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1585-92.
1998: Paolo Montuschi; Giovanni Ciabattoni; Paolo Paredi; P Pantelidis; Roland M Du Bois; Sergei A Kharitonov; Peter J Barnes
8-Isoprostane as a biomarker of oxidative stress in interstitial lung diseases.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1524-7.
1998: Sergei A Kharitonov; M A Sapienza; Peter J Barnes; K Fan Chung
Prostaglandins E2 and F2alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1374-8.
1998: Alison A Hislop; J C Mak; Jayne A Reader; Peter J Barnes; Sheila G Haworth
Muscarinic receptor subtypes in the porcine lung during postnatal development.
European journal of pharmacology 1998;359(2-3):211-21.
1998: I Horvath; S Loukides; T Wodehouse; Sergei A Kharitonov; Peter J Cole; Peter J Barnes
Increased levels of exhaled carbon monoxide in bronchiectasis: a new marker of oxidative stress.
Thorax 1998;53(10):867-70.
1998: Federico P Gómez; Joan A Barberà; Josep Roca; Raquel Iglesia; J Ribas; Peter J Barnes; Robert Rodriguez-Roisin
Effect of nitric oxide synthesis inhibition with nebulized L-NAME on ventilation-perfusion distributions in bronchial asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(4):865-71.
1998: Peter J Barnes
Chronic obstructive pulmonary disease: new opportunities for drug development.
Trends in pharmacological sciences 1998;19(10):415-23.
1998: Peter J Barnes
Efficacy of inhaled corticosteroids in asthma.
The Journal of allergy and clinical immunology 1998;102(4 Pt 1):531-8.
1998: Peter J Barnes; S Lim
Inhibitory cytokines in asthma.
Molecular medicine today 1998;4(10):452-8.
1998: Ildikó Horváth; Louise E Donnelly; A Kiss; Sergei A Kharitonov; Sam Lim; K Fan Chung; Peter J Barnes
Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma.
American journal of respiratory and critical care medicine 1998;158(4):1042-6.
1998: Mark A Lindsay; EB Haddad; J Rousell; Mauro Teixeira; Paul G Hellewell; Peter J Barnes; Mark A Giembycz
Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation.
Journal of leukocyte biology 1998;64(4):555-62.
1998: L C Wright; J Seybold; A Robichaud; Ian M Adcock; Peter J Barnes
Phosphodiesterase expression in human epithelial cells.
The American journal of physiology 1998;275(4 Pt 1):L694-700.
1998: Paolo Paredi; S Loukides; Simon Ward; Derek Cramer; M Spicer; Sergei A Kharitonov; Peter J Barnes
Exhalation flow and pressure-controlled reservoir collection of exhaled nitric oxide for remote and delayed analysis.
Thorax 1998;53(9):775-9.
1998: S Loukides; I Horvath; T Wodehouse; Peter J Cole; Peter J Barnes
Elevated levels of expired breath hydrogen peroxide in bronchiectasis.
American journal of respiratory and critical care medicine 1998;158(3):991-4.
1998: J Seybold; Robert Newton; L Wright; PA Finney; N Suttorp; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.
The Journal of biological chemistry 1998;273(32):20575-88.
1998: Ildikó Horváth; Louise E Donnelly; A Kiss; Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress.
Thorax 1998;53(8):668-72.
1998: Ian M Adcock; Y Nasuhari; Peter J Barnes
Role of CBP in glucocorticoid-induced gene repression.
Biochemical Society transactions 1998;26(3):S255.
1998: S Loukides; Sergei A Kharitonov; T Wodehouse; Peter J Cole; Peter J Barnes
Effect of arginine on mucociliary function in primary ciliary dyskinesia.
Lancet 1998;352(9125):371-2.
1998: D Saleh; Pierre Ernst; S Lim; Peter J Barnes; Adel Giaid
Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(11):929-37.
1998: Hema J Patel; Mark A Giembycz; J E Keeling; Peter J Barnes; Maria G Belvisi
Inhibition of cholinergic neurotransmission in guinea pig trachea by NS1619, a putative activator of large-conductance, calcium-activated potassium channels.
The Journal of pharmacology and experimental therapeutics 1998;286(2):952-8.
1998: S Lim; E Crawley; P Woo; Peter J Barnes
Haplotype associated with low interleukin-10 production in patients with severe asthma.
Lancet 1998;352(9122):113.
1998: Julia A Nightingale; Duncan F Rogers; LA Hart; Sergei A Kharitonov; K Fan Chung; Peter J Barnes
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects.
Thorax 1998;53(7):563-71.
1998: L A Adisesh; Sergei A Kharitonov; Deborah H Yates; D C Snashell; A J Newman-Taylor; Peter J Barnes
Exhaled and nasal nitric oxide is increased in laboratory animal allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(7):876-80.
1998: Peter J Barnes; Ian M Adcock
Transcription factors and asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(1):221-34.
1998: DA Taylor; J L McGrath; Brian J O'connor; Peter J Barnes
Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide.
American journal of respiratory and critical care medicine 1998;158(1):99-106.
1998: Peter J Barnes
Anti-inflammatory actions of glucocorticoids: molecular mechanisms.
Clinical science (London, England : 1979) 1998;94(6):557-72.
1998: DA Taylor; J L McGrath; L M Orr; Peter J Barnes; Brian J O'connor
Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'-monophosphate in asthma.
Thorax 1998;53(6):483-9.
1998: Robert Newton; LA Hart; DA Stevens; M Bergmann; Louise E Donnelly; Ian M Adcock; Peter J Barnes
Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells.
European journal of biochemistry / FEBS 1998;254(1):81-9.
1998: Peter J Barnes
Anti-leukotrienes: a new treatment for asthma.
The Practitioner 1998;242(1586):395-9.
1998: J Efthimiou; Peter J Barnes
Effect of inhaled corticosteroids on bones and growth.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;11(5):1167-77.
1998: J J Kelly; Peter J Barnes; Mark A Giembycz
Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors.
British journal of pharmacology 1998;124(1):129-40.
1998: Mark A Lindsay; R S Perkins; Peter J Barnes; Mark A Giembycz
Leukotriene B4 activates the NADPH oxidase in eosinophils by a pertussis toxin-sensitive mechanism that is largely independent of arachidonic acid mobilization.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4526-34.
1998: K F Chung; Peter J Barnes
Zafirlukast (Accolate).
Drugs of today (Barcelona, Spain : 1998) 1998;34(4):375-88.
1998: Jon G Ayres; JF Miles; Peter J Barnes
Brittle asthma.
Thorax 1998;53(4):315-21.
1998: Peter J Barnes
Current issues for establishing inhaled corticosteroids as the antiinflammatory agents of choice in asthma.
The Journal of allergy and clinical immunology 1998;101(4 Pt 2):S427-33.
1998: M Bergmann; L Hart; M Lindsay; Peter J Barnes; Robert Newton
IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway.
The Journal of biological chemistry 1998;273(12):6607-10.
1998: M A Sapienza; Sergei A Kharitonov; I Horvath; K Fan Chung; Peter J Barnes
Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects.
Thorax 1998;53(3):172-5.
1998: U G Lalloo; Sam Lim; R DuBois; Peter J Barnes; K Fan Chung
Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;11(3):702-5.
1998: Lucia Spicuzza; Mark A Giembycz; Peter J Barnes; Maria G Belvisi
Prostaglandin E2 suppression of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by interacting with prostanoid receptors of the EP3-subtype.
British journal of pharmacology 1998;123(6):1246-52.
1998: JL Pype; Lieven J Dupont; JC Mak; Peter J Barnes; Geert M Verleden
Regulation of H1-receptor coupling and H1-receptor mRNA by histamine in bovine tracheal smooth muscle.
British journal of pharmacology 1998;123(5):984-90.
1998: Peter J Barnes; S Pedersen; W W Busse
Efficacy and safety of inhaled corticosteroids. New developments.
American journal of respiratory and critical care medicine 1998;157(3 Pt 2):S1-53.
1998: Wasim Maziak; S Loukides; Sarah V Culpitt; P Sullivan; Sergei A Kharitonov; Peter J Barnes
Exhaled nitric oxide in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1998;157(3 Pt 1):998-1002.
1998: Michael Salmon; H Koto; OT Lynch; EB Haddad; Nicholas J Lamb; Gregory J Quinlan; Peter J Barnes; K Fan Chung
Proliferation of airway epithelium after ozone exposure: effect of apocynin and dexamethasone.
American journal of respiratory and critical care medicine 1998;157(3 Pt 1):970-7.
1998: Paul M Seldon; D A Stevens; Ian M Adcock; Brian J O'connor; Peter J Barnes; Mark A Giembycz
Albuterol does not antagonize the inhibitory effect of dexamethasone on monocyte cytokine release.
American journal of respiratory and critical care medicine 1998;157(3 Pt 1):803-9.
1998: Toshio Katsunuma; Judith C W Mak; Peter J Barnes
Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle.
European journal of pharmacology 1998;344(1):99-106.
1998: Peter J Barnes
New therapies for chronic obstructive pulmonary disease.
Thorax 1998;53(2):137-47.
1998: Deborah H Yates; M Worsdell; Peter J Barnes
Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle beta 2 adrenergic tolerance in mild asthma.
Thorax 1998;53(2):110-3.
1998: Anon Jatakanon; Sam Lim; Sergei A Kharitonov; K Fan Chung; Peter J Barnes
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.
Thorax 1998;53(2):91-5.
1998: Julia A Nightingale; Duncan F Rogers; Peter J Barnes
Effect of repeated sputum induction on cell counts in normal volunteers.
Thorax 1998;53(2):87-90.
1998: Paul M Seldon; Peter J Barnes; Mark A Giembycz
Interleukin-10 does not mediate the inhibitory effect of PDE-4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumors necrosis factor-alpha generation from human peripheral blood monocytes.
Cell biochemistry and biophysics 1998;29(1-2):179-201.
1998: Matthias John; BT Au; Peter J Jose; Sam Lim; M Saunders; Peter J Barnes; Jane A Mitchell; Maria G Belvisi; K Fan Chung
Expression and release of interleukin-8 by human airway smooth muscle cells: inhibition by Th-2 cytokines and corticosteroids.
American journal of respiratory cell and molecular biology 1998;18(1):84-90.
1998: M John; Sam Lim; J Seybold; P Jose; A Robichaud; B O'Connor; Peter J Barnes; K Fan Chung
Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma.
American journal of respiratory and critical care medicine 1998;157(1):256-62.
1997: Sergei A Kharitonov; JB Cailes; Carol M Black; Roland M Du Bois; Peter J Barnes
Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension.
Thorax 1997;52(12):1051-5.
1997: J Rousell; Mark A Lindsay; Peter J Barnes
Regulation of m2 muscarinic receptor gene expression by platelet-derived growth factor: involvement of extracellular signal-regulated protein kinases in the down-regulation process.
Molecular pharmacology 1997;52(6):966-73.
1997: DA Taylor; Marianne W Jensen; S L Aikman; J G Harris; Peter J Barnes; Brian J O'connor
Comparison of salmeterol and albuterol-induced bronchoprotection against adenosine monophosphate and histamine in mild asthma.
American journal of respiratory and critical care medicine 1997;156(6):1731-7.
1997: Robert Newton; DA Stevens; LA Hart; M Lindsay; Ian M Adcock; Peter J Barnes
Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation.
FEBS letters 1997;418(1-2):135-8.
1997: D J Evans; D A Taylor; O Zetterstrom; K Fan Chung; Brian J O'connor; Peter J Barnes
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma.
The New England journal of medicine 1997;337(20):1412-8.
1997: Romain A Pauwels; Claes-Göran AH Löfdahl; Dirkje S Postma; Anne E Tattersfield; Paul M O'Byrne; Peter J Barnes; Anders Ullman
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.
The New England journal of medicine 1997;337(20):1405-11.
1997: M Bergmann; Peter J Barnes
[Molecular biologic aspects of chronic inflammation reaction in bronchial asthma: incentive for new therapeutic concepts?].
Pneumologie (Stuttgart, Germany) 1997;51(11):1071-8.
1997: CA Byrnes; S Dinarevic; Elliot A Shinebourne; Peter J Barnes; Andrew Bush
Exhaled nitric oxide measurements in normal and asthmatic children.
Pediatric pulmonology 1997;24(5):312-8.
1997: Deborah H Yates; M Worsdell; Peter J Barnes
Effect of regular salmeterol treatment on albuterol-induced bronchoprotection in mild asthma.
American journal of respiratory and critical care medicine 1997;156(3 Pt 1):988-91.
1997: koremu meja; Peter J Barnes; Mark A Giembycz
Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation.
British journal of pharmacology 1997;122(1):149-57.
1997: Robert Newton; LM Kuitert; M Bergmann; Ian M Adcock; Peter J Barnes
Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta.
Biochemical and biophysical research communications 1997;237(1):28-32.
1997: R A Stone; Peter J Barnes; K Fan Chung
Effect of 5-HT1A receptor agonist, 8-OH-DPAT, on cough responses in the conscious guinea pig.
European journal of pharmacology 1997;332(2):201-7.
1997: Shu Liu; EB Haddad; Ian M Adcock; Michael Salmon; H Koto; T Gilbey; Peter J Barnes; K Fan Chung
Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung.
British journal of pharmacology 1997;121(7):1241-6.
1997: BL Webb; Mark A Lindsay; J Seybold; N J Brand; Magdi H Yacoub; EB Haddad; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level.
Biochemical pharmacology 1997;54(1):199-205.
1997: D J Evans; Peter J Barnes; M Cluzel; B J O'Connor
Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses.
American journal of respiratory and critical care medicine 1997;156(1):11-6.
1997: Sergei A Kharitonov; K Alving; Peter J Barnes
Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(7):1683-93.
1997: D H Yates; Sergei A Kharitonov; Peter J Barnes
Effect of short- and long-acting inhaled beta2-agonists on exhaled nitric oxide in asthmatic patients.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(7):1483-8.
1997: Peter J Barnes
Nuclear factor-kappa B.
The international journal of biochemistry & cell biology 1997;29(6):867-70.
1997: Sergei A Kharitonov; Peter J Barnes
Nasal contribution to exhaled nitric oxide during exhalation against resistance or during breath holding.
Thorax 1997;52(6):540-4.
1997: Angela Haczku; Paul A MacAry; Tung-Jung Huang; H Tsukagoshi; Peter J Barnes; A Barry Kay; David M Kemeny; K F Chung; R Moqbel
Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in brown-Norway rats.
Immunology 1997;91(2):176-85.
1997: Jane A Mitchell; M Saunders; Peter J Barnes; R Newton; Maria G Belvisi
Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid.
Molecular pharmacology 1997;51(6):907-12.
1997: BL Webb; Mark A Lindsay; Peter J Barnes; Mark A Giembycz
Protein kinase C isoenzymes in airway smooth muscle.
The Biochemical journal 1997;324 ( Pt 1)():167-75.
1997: Robert Newton; J Seybold; Shu Liu; Peter J Barnes
Alternate COX-2 transcripts are differentially regulated: implications for post-transcriptional control.
Biochemical and biophysical research communications 1997;234(1):85-9.
1997: Ian M Adcock; R Newton; Peter J Barnes
NF-kappa B involvement in IL-1 beta-induction of GM-CSF and COX-2: inhibition by glucocorticoids does not require I-kappa B.
Biochemical Society transactions 1997;25(2):154S.
1997: VM Keatings; Brian J O'connor; L G Wright; David P Huston; Christopher J Corrigan; Peter J Barnes
Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum.
The Journal of allergy and clinical immunology 1997;99(5):693-8.
1997: D Saleh; Peter J Barnes; Adel Giaid
Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 1997;155(5):1763-9.
1997: T Takahashi; Peter J Barnes; I Kawikova; Magdi H Yacoub; Timothy D Warner; Maria G Belvisi
Contraction of human airway smooth muscle by endothelin-1 and IRL 1620: effect of bosentan.
European journal of pharmacology 1997;324(2-3):219-22.
1997: Peter J Barnes; Michael Karin
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
The New England journal of medicine 1997;336(15):1066-71.
1997: VM Keatings; D J Evans; Brian J O'connor; Peter J Barnes
Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid.
Thorax 1997;52(4):372-4.
1997: M G Belvisi; MA Saunders; S J Hirst; Magdi H Yacoub; Peter J Barnes; Jane A Mitchell
Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type.
British journal of pharmacology 1997;120(5):910-6.
1997: Hema J Patel; Mark A Giembycz; Lucia Spicuzza; Peter J Barnes; Maria G Belvisi
Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin.
British journal of pharmacology 1997;120(5):735-6.
1997: Shu Liu; Peter J Barnes; Timothy W Evans
Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo.
Critical care medicine 1997;25(3):512-8.
1997: M Bernareggi; Jane A Mitchell; Peter J Barnes; Maria G Belvisi
Dual action of nitric oxide on airway plasma leakage.
American journal of respiratory and critical care medicine 1997;155(3):869-74.
1997: M John; Stuart J Hirst; P J Jose; A Robichaud; N Berkman; C Witt; Charles H C Twort; Peter J Barnes; K Fan Chung
Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1841-7.
1997: Peter J Barnes; I M Adcock
NF-kappa B: a pivotal role in asthma and a new target for therapy.
Trends in pharmacological sciences 1997;18(2):46-50.
1997: MA Saunders; Jane A Mitchell; Paul M Seldon; Magdi H Yacoub; Peter J Barnes; Mark A Giembycz; M G Belvisi
Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone.
British journal of pharmacology 1997;120(4):545-6.
1997: Peter J Barnes
Current therapies for asthma. Promise and limitations.
Chest 1997;111(2 Suppl):17S-26S.
1997: James N Baraniuk; Mushtaq Ali; D Brody; J Maniscalco; E Gaumond; TK Fitzgerald; G Wong; Atsushi Yuta; J C Mak; Peter J Barnes; Rebecca Bascom; Thomas R Troost
Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa.
American journal of respiratory and critical care medicine 1997;155(2):704-10.
1997: VM Keatings; Anon Jatakanon; Y M Worsdell; Peter J Barnes
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD.
American journal of respiratory and critical care medicine 1997;155(2):542-8.
1997: VM Keatings; Peter J Barnes
Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects.
American journal of respiratory and critical care medicine 1997;155(2):449-53.
1997: D Saleh; K Furukawa; Ming Tsao; Azzam A Maghazachi; B Corrin; M Yanagisawa; Peter J Barnes; Adel Giaid
Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines.
American journal of respiratory cell and molecular biology 1997;16(2):187-93.
1997: A J Fox; Peter J Barnes; P Venkatesan; Maria G Belvisi
Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig.
The Journal of clinical investigation 1997;99(3):513-9.
1997: Peter J Barnes
Neural mechanisms in asthma: new developments.
Pediatric pulmonology. Supplement 1997;16():82-3.
1997: Peter J Barnes
Molecular mechanisms of glucocorticoid action in asthma.
Pulmonary pharmacology & therapeutics 1997;10(1):3-19.
1997: Judith C W Mak; Peter J Barnes
In situ hybridization.
Methods in molecular biology (Clifton, N.J.) 1997;83():81-9.
1997: Peter J Barnes; EB Haddad; J Rousell
Regulation of muscarinic M2 receptors.
Life sciences 1997;60(13-14):1015-21.
1997: Sergei A Kharitonov; K Rajakulasingam; B O'Connor; S R Durham; Peter J Barnes
Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids.
The Journal of allergy and clinical immunology 1997;99(1 Pt 1):58-64.
1997: Robert Newton; LM Kuitert; Donna M Slater; Ian M Adcock; Peter J Barnes
Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells.
Life sciences 1997;60(1):67-78.
1996: M Nishikawa; Judith C W Mak; Peter J Barnes
Effect of short- and long-acting beta 2-adrenoceptor agonists on pulmonary beta 2-adrenoceptor expression in human lung.
European journal of pharmacology 1996;318(1):123-9.
1996: EB Haddad; J Rousell; Mark A Lindsay; Peter J Barnes
Synergy between tumor necrosis factor alpha and interleukin 1beta in inducing transcriptional down-regulation of muscarinic M2 receptor gene expression. Involvement of protein kinase A and ceramide pathways.
The Journal of biological chemistry 1996;271(51):32586-92.
1996: Sergei A Kharitonov; Peter J Barnes
Nitric oxide in exhaled air is a new marker of airway inflammation.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1996;51(6):533-7.
1996: L M Kuitert; Robert Newton; N C Barnes; Ian M Adcock; Peter J Barnes
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Thorax 1996;51(12):1223-8.
1996: D J Evans; Peter J Barnes; SM Spaethe; E L van Alstyne; M I Mitchell; Brian J O'connor
Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma.
Thorax 1996;51(12):1178-84.
1996: N Berkman; V L Krishnan; T Gilbey; R Newton; B O'Connor; Peter J Barnes; K Fan Chung
Expression of RANTES mRNA and protein in airways of patients with mild asthma.
American journal of respiratory and critical care medicine 1996;154(6 Pt 1):1804-11.
1996: Deborah H Yates; Sergei A Kharitonov; Peter J Barnes
An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta 2-agonist.
American journal of respiratory and critical care medicine 1996;154(6 Pt 1):1603-7.
1996: N Berkman; A Robichaud; R A Robbins; G Roesems; EB Haddad; Peter J Barnes; K Fan Chung
Inhibition of inducible nitric oxide synthase expression by interleukin-4 and interleukin-13 in human lung epithelial cells.
Immunology 1996;89(3):363-7.
1996: U G Lalloo; Peter J Barnes; K Fan Chung
Pathophysiology and clinical presentations of cough.
The Journal of allergy and clinical immunology 1996;98(5 Pt 2):S91-6; discussion S96-7.
1996: Peter J Barnes
Neuroeffector mechanisms: the interface between inflammation and neuronal responses.
The Journal of allergy and clinical immunology 1996;98(5 Pt 2):S73-81; discussion S81-3.
1996: Peter J Barnes
Is there a role for immunotherapy in the treatment of asthma? No.
American journal of respiratory and critical care medicine 1996;154(5):1227-8.
1996: H Koto; Judith C W Mak; EB Haddad; W B Xu; Michael Salmon; Peter J Barnes; K Fan Chung
Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat.
The Journal of clinical investigation 1996;98(8):1780-7.
1996: B J O'Connor; L J Towse; Peter J Barnes
Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma.
American journal of respiratory and critical care medicine 1996;154(4 Pt 1):876-80.
1996: N Berkman; M John; G Roesems; P Jose; Peter J Barnes; K Fan Chung
Interleukin 13 inhibits macrophage inflammatory protein-1 alpha production from human alveolar macrophages and monocytes.
American journal of respiratory cell and molecular biology 1996;15(3):382-9.
1996: Ian M Adcock; T Gilbey; C M Gelder; K Fan Chung; Peter J Barnes
Glucocorticoid receptor localization in normal and asthmatic lung.
American journal of respiratory and critical care medicine 1996;154(3 Pt 1):771-82.
1996: J J Kelly; Peter J Barnes; Mark A Giembycz
Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [3H]R-(-)-rolipram binding by selective inhibitors.
The Biochemical journal 1996;318 ( Pt 2)():425-36.
1996: Ian M Adcock; C R Brown; Peter J Barnes
Tumour necrosis factor alpha causes retention of activated glucocorticoid receptor within the cytoplasm of A549 cells.
Biochemical and biophysical research communications 1996;225(2):545-50.
1996: V Steinkraus; J C Mak; Uwe Pichlmeier; H Mensing; J Ring; Peter J Barnes
Autoradiographic mapping of beta-adrenoceptors in human skin.
Archives of dermatological research 1996;288(9):549-53.
1996: Peter J Barnes
Immunomodulation as asthma therapy: where do we stand?
The European respiratory journal. Supplement 1996;22():154s-159s.
1996: Mark A Giembycz; C J Corrigan; J Seybold; Robert Newton; Peter J Barnes
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2.
British journal of pharmacology 1996;118(8):1945-58.
1996: Peter J Barnes
Inhaled glucocorticoids: new developments relevant to updating of the asthma management guidelines.
Respiratory medicine 1996;90(7):379-84.
1996: G B Marks; D H Yates; M Sist; B Ceyhan; M De Campos; D M Scott; Peter J Barnes
Respiratory sensation during bronchial challenge testing with methacholine, sodium metabisulphite, and adenosine monophosphate.
Thorax 1996;51(8):793-8.
1996: Peter J Barnes
Mechanisms of action of glucocorticoids in asthma.
American journal of respiratory and critical care medicine 1996;154(2 Pt 2):S21-6; discussion S26-7.
1996: Peter J Barnes
New drugs for asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(7):738-45.
1996: Peter J Barnes
Pathophysiology of asthma.
British journal of clinical pharmacology 1996;42(1):3-10.
1996: Deborah H Yates; Sergei A Kharitonov; Paul S Thomas; Peter J Barnes
Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase.
American journal of respiratory and critical care medicine 1996;154(1):247-50.
1996: Shu Liu; Ian M Adcock; R W Old; Peter J Barnes; Timothy W Evans
Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysaccharide treatment in vivo in the rat.
Critical care medicine 1996;24(7):1219-25.
1996: A J Fox; U G Lalloo; Maria G Belvisi; M Bernareggi; K Fan Chung; Peter J Barnes
Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough.
Nature medicine 1996;2(7):814-7.
1996: Peter J Barnes
Transcription factors and inflammatory disease.
Hospital practice (1995) 1996;31(6):93-100, 105-6.
1996: Deborah H Yates; Sergei A Kharitonov; R A Robbins; Paul S Thomas; Peter J Barnes
The effect of alcohol ingestion on exhaled nitric oxide.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(6):1130-3.
1996: S I Ramnarine; AM Khawaja; Peter J Barnes; Duncan F Rogers
Nitric oxide inhibition of basal and neurogenic mucus secretion in ferret trachea in vitro.
British journal of pharmacology 1996;118(4):998-1002.
1996: EB Haddad; Judith C W Mak; Maria G Belvisi; M Nishikawa; J Rousell; Peter J Barnes
Muscarinic and beta-adrenergic receptor expression in peripheral lung from normal and asthmatic patients.
The American journal of physiology 1996;270(6 Pt 1):L947-53.
1996: Sergei A Kharitonov; K Fan Chung; D Evans; Brian J O'connor; Peter J Barnes
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract.
American journal of respiratory and critical care medicine 1996;153(6 Pt 1):1773-80.
1996: Peter J Barnes
What is the role of nerves in chronic asthma and symptoms?
American journal of respiratory and critical care medicine 1996;153(6 Pt 2):S5-8.
1996: Peter J Barnes; F W Liew
Why does asthma become persistent?
American journal of respiratory and critical care medicine 1996;153(6 Pt 2):S23-5.
1996: C M Gelder; J F Morrison; K Fan Chung; Peter J Barnes; Ian M Adcock
T cell receptor repertoire in peripheral blood and bronchial biopsies from normal and asthmatic subjects.
Biochemical Society transactions 1996;24(2):316S.
1996: C M Gelder; Peter J Barnes; Brian J O'connor; K Fan Chung; Ian M Adcock
Cytokine mRNA profiles of normal and asthmatic peripheral blood cells and endobronchial biopsies.
Biochemical Society transactions 1996;24(2):315S.
1996: Ian M Adcock; Peter J Barnes
Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation.
Biochemical Society transactions 1996;24(2):267S.
1996: EB Haddad; J Rousell; Judith C W Mak; Peter J Barnes
Transforming growth factor-beta 1 induces transcriptional down-regulation of m2 muscarinic receptor gene expression.
Molecular pharmacology 1996;49(5):781-7.
1996: Judith C W Mak; M Nishikawa; EB Haddad; O J Kwon; Stuart J Hirst; Charles H C Twort; Peter J Barnes
Localisation and expression of beta-adrenoceptor subtype mRNAs in human lung.
European journal of pharmacology 1996;302(1-3):215-21.
1996: Shu Liu; Robert Newton; Timothy W Evans; Peter J Barnes
Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in vivo in the rat.
Clinical science (London, England : 1979) 1996;90(4):301-6.
1996: Maria G Belvisi; Hema J Patel; T Takahashi; Peter J Barnes; Mark A Giembycz
Paradoxical facilitation of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by isoprenaline.
British journal of pharmacology 1996;117(7):1413-20.
1996: D J Evans; Mark A Lindsay; Brian J O'connor; Peter J Barnes
Priming of circulating human eosinophils following late response to allergen challenge.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(4):703-8.
1996: Peter J Barnes; B Jonsson; J B Klim
The costs of asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(4):636-42.
1996: N Berkman; A Robichaud; V L Krishnan; G Roesems; R Robbins; Peter J Jose; Peter J Barnes; K Fan Chung
Expression of RANTES in human airway epithelial cells: effect of corticosteroids and interleukin-4, -10 and -13.
Immunology 1996;87(4):599-603.
1996: J Rousell; EB Haddad; Judith C W Mak; BL Webb; Mark A Giembycz; Peter J Barnes
Beta-Adrenoceptor-medicated down-regulation of M2 muscarinic receptors: role of cyclic adenosine 5'-monophosphate-dependent protein kinase and protein kinase C.
Molecular pharmacology 1996;49(4):629-35.
1996: Peter J Barnes; Sergei A Kharitonov
Exhaled nitric oxide: a new lung function test.
Thorax 1996;51(3):233-7.
1996: T Sakamoto; Peter J Barnes; K Fan Chung
Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(3):123-6.
1996: Stuart J Hirst; Peter J Barnes; Charles H C Twort
PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells.
The American journal of physiology 1996;270(3 Pt 1):L415-28.
1996: Peter J Barnes
Is immunotherapy for asthma worthwhile?
The New England journal of medicine 1996;334(8):531-2.
1996: EB Haddad; Michael Salmon; H Koto; Peter J Barnes; Ian M Adcock; K Fan Chung
Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids.
FEBS letters 1996;379(3):265-8.
1996: Y H Lei; Peter J Barnes; Duncan F Rogers
Involvement of hydroxyl radicals in neurogenic airway plasma exudation and bronchoconstriction in guinea-pigs in vivo.
British journal of pharmacology 1996;117(3):449-454.
1996: Sergei A Kharitonov; Deborah H Yates; K Fan Chung; Peter J Barnes
Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(2):196-201.
1996: Peter J Barnes
NO or no NO in asthma?
Thorax 1996;51(2):218-20.
1996: I Kawikova; Peter J Barnes; T Takahashi; S Tadjkarimi; M H Yacoub; Maria G Belvisi
8-Epi-PGF2 alpha, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro.
American journal of respiratory and critical care medicine 1996;153(2):590-6.
1996: VM Keatings; PD Collins; D M Scott; Peter J Barnes
Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.
American journal of respiratory and critical care medicine 1996;153(2):530-4.
1996: J C Kidney; J O Lotvall; Y Lei; K Fan Chung; Peter J Barnes
The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs.
European journal of pharmacology 1996;296(1):81-7.
1996: Robert Newton; Ian M Adcock; Peter J Barnes
Superinduction of NF-kappa B by actinomycin D and cycloheximide in epithelial cells.
Biochemical and biophysical research communications 1996;218(2):518-23.
1996: Peter J Barnes
Asthma therapy with aerosols: clinical relevance for the next decade.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 1996;9(1):131-41.
1996: Judith C W Mak; M Astolfi; X L Zhang; S Evangelista; S Manzini; Peter J Barnes
Autoradiographic mapping of pulmonary NK1 and NK2 tachykinin receptors and changes after repeated antigen challenge in guinea pigs.
Peptides 1996;17(8):1389-95.
1996: Ian M Adcock; D A Stevens; Peter J Barnes
Interactions of glucocorticoids and beta 2-agonists.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(1):160-8.
1996: M P Hallsworth; M A Giembycz; Peter J Barnes; Tak H Lee
Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF.
British journal of pharmacology 1996;117(1):79-86.
1996: Peter J Barnes
Molecular mechanisms of steroid action in asthma.
The Journal of allergy and clinical immunology 1996;97(1 Pt 2):159-68.
1996: Sergei A Kharitonov; Deborah H Yates; Peter J Barnes
Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.
American journal of respiratory and critical care medicine 1996;153(1):454-7.
1995: A D Cambrey; O J Kwon; A J Gray; N K Harrison; M Yacoub; Peter J Barnes; Geoffrey J Laurent; K Fan Chung
Insulin-like growth factor I is a major fibroblast mitogen produced by primary cultures of human airway epithelial cells.
Clinical science (London, England : 1979) 1995;89(6):611-7.
1995: Deborah H Yates; Brian J O'connor; G Yilmaz; S Aikman; M Worsdell; Peter J Barnes; K Fan Chung
Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma.
American journal of respiratory and critical care medicine 1995;152(6 Pt 1):2173-5.
1995: Ian M Adcock; S J Lane; C R Brown; Tak H Lee; Peter J Barnes
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.
The Journal of experimental medicine 1995;182(6):1951-8.
1995: Peter J Barnes; A P Greening; G K Crompton
Glucocorticoid resistance in asthma.
American journal of respiratory and critical care medicine 1995;152(6 Pt 2):S125-40.
1995: Peter J Barnes
Nitric oxide and asthma.
Research in immunology 1995;146(9):698-702.
1995: Peter J Barnes
Anti-inflammatory mechanisms of glucocorticoids.
Biochemical Society transactions 1995;23(4):940-5.
1995: Deborah H Yates; M J Peters; V Keatings; Paul S Thomas; Peter J Barnes
Reduced dose salbutamol in comparison with standard dosage for symptom relief in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(11):1847-51.
1995: Peter J Barnes; I M Adcock
Transcription factors.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25 Suppl 2():46-9.
1995: W B Xu; EB Haddad; H Tsukagoshi; Ian M Adcock; Peter J Barnes; K Fan Chung
Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung.
Thorax 1995;50(11):1136-40.
1995: N Berkman; M John; G Roesems; Peter J Jose; Peter J Barnes; K Fan Chung
Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4412-8.
1995: EB Haddad; Shu Liu; Michael Salmon; A Robichaud; Peter J Barnes; K Fan Chung
Expression of inducible nitric oxide synthase mRNA in Brown Norway rats exposed to ozone: effect of dexamethasone.
European journal of pharmacology 1995;293(3):287-90.
1995: EB Haddad; J Rousell; Judith C W Mak; Peter J Barnes
Long-term carbachol treatment-induced down-regulation of muscarinic M2-receptors but not m2 receptor mRNA in a human lung cell line.
British journal of pharmacology 1995;116(3):2027-32.
1995: U G Lalloo; A J Fox; Maria G Belvisi; K Fan Chung; Peter J Barnes
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;79(4):1082-7.
1995: Peter J Barnes
Molecular mechanisms of antiasthma therapy.
Annals of medicine 1995;27(5):531-5.
1995: Deborah H Yates; H S Sussman; M J Shaw; Peter J Barnes; K Fan Chung
Regular formoterol treatment in mild asthma. Effect on bronchial responsiveness during and after treatment.
American journal of respiratory and critical care medicine 1995;152(4 Pt 1):1170-4.
1995: C M Gelder; Paul S Thomas; Deborah H Yates; Ian M Adcock; J F Morrison; Peter J Barnes
Cytokine expression in normal, atopic, and asthmatic subjects using the combination of sputum induction and the polymerase chain reaction.
Thorax 1995;50(10):1033-7.
1995: N Berkman; Peter J Jose; Timothy J Williams; T J Schall; Peter J Barnes; K Fan Chung
Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages.
The American journal of physiology 1995;269(4 Pt 1):L443-52.
1995: Paul M Seldon; Peter J Barnes; K Meja; Mark A Giembycz
Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.
Molecular pharmacology 1995;48(4):747-57.
1995: R S Perkins; Mark A Lindsay; Peter J Barnes; Mark A Giembycz
Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.
The Biochemical journal 1995;310 ( Pt 3)():795-806.
1995: Maria G Belvisi; Peter J Barnes; S Larkin; M Yacoub; S Tadjkarimi; T J Williams; J A Mitchell
Nitric oxide synthase activity is elevated in inflammatory lung disease in humans.
European journal of pharmacology 1995;283(1-3):255-8.
1995: James N Baraniuk; K Ohkubo; O J Kwon; J Mak; M Ali; R Davies; Charles H C Twort; M Kaliner; M Letarte; Peter J Barnes
Localization of neutral endopeptidase (NEP) mRNA in human bronchi.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(9):1458-64.
1995: Deborah H Yates; Sergei A Kharitonov; R A Robbins; Paul S Thomas; Peter J Barnes
Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide.
American journal of respiratory and critical care medicine 1995;152(3):892-6.
1995: Hema J Patel; Peter J Barnes; T Takahashi; S Tadjkarimi; M H Yacoub; Maria G Belvisi
Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea.
American journal of respiratory and critical care medicine 1995;152(3):872-8.
1995: Peter J Barnes
Beta-adrenergic receptors and their regulation.
American journal of respiratory and critical care medicine 1995;152(3):838-60.
1995: EB Haddad; J Rousell; Peter J Barnes
Muscarinic M2 receptor synthesis: study of receptor turnover with propylbenzilylcholine mustard.
European journal of pharmacology 1995;290(3):201-5.
1995: Peter J Barnes
Overview of neural mechanisms in asthma.
Pulmonary pharmacology 1995;8(4-5):151-9.
1995: A J Fox; L Urban; Peter J Barnes; A Dray
Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig.
Neuroscience 1995;67(3):741-52.
1995: Peter J Barnes; S T Holgate; L A Laitinen; R Pauwels
Asthma mechanisms, determinants of severity and treatment: the role of nedocromil sodium. Report of a workshop held in Whistler, British Columbia, Canada, 18-19 May 1995.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(8):771-87.
1995: Angela Haczku; K Fan Chung; J Sun; Peter J Barnes; A Barry Kay; Redwan Moqbel
Airway hyperresponsiveness, elevation of serum-specific IgE and activation of T cells following allergen exposure in sensitized Brown-Norway rats.
Immunology 1995;85(4):598-603.
1995: Angela Haczku; Redwan Moqbel; M Jacobson; A Barry Kay; Peter J Barnes; K Fan Chung
T-cells subsets and activation in bronchial mucosa of sensitized Brown-Norway rats after single allergen exposure.
Immunology 1995;85(4):591-7.
1995: Sergei A Kharitonov; R A Robbins; D Yates; VM Keatings; Peter J Barnes
Acute and chronic effects of cigarette smoking on exhaled nitric oxide.
American journal of respiratory and critical care medicine 1995;152(2):609-12.
1995: J K Ward; Peter J Barnes; David R Springall; luigi abelli; S Tadjkarimi; M H Yacoub; Julia M Polak; Maria G Belvisi
Distribution of human i-NANC bronchodilator and nitric oxide-immunoreactive nerves.
American journal of respiratory cell and molecular biology 1995;13(2):175-84.
1995: Peter J Barnes; I M Adcock
Steroid resistance in asthma.
QJM : monthly journal of the Association of Physicians 1995;88(7):455-68.
1995: Judith C W Mak; M Nishikawa; H Shirasaki; K Miyayasu; Peter J Barnes
Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo.
The Journal of clinical investigation 1995;96(1):99-106.
1995: Paul S Thomas; Deborah H Yates; Peter J Barnes
Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects.
American journal of respiratory and critical care medicine 1995;152(1):76-80.
1995: T Takahashi; J K Ward; S Tadjkarimi; M H Yacoub; Peter J Barnes; Maria G Belvisi
5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways.
American journal of respiratory and critical care medicine 1995;152(1):377-80.
1995: Peter J Barnes
Air pollution and asthma: molecular mechanisms.
Molecular medicine today 1995;1(3):149-55.
1995: H Tsukagoshi; EB Haddad; Peter J Barnes; K Fan Chung
Bradykinin receptor subtypes in rat lung: effect of interleukin-1 beta.
The Journal of pharmacology and experimental therapeutics 1995;273(3):1257-63.
1995: J Kidney; M Dominguez; P M Taylor; M Rose; K Fan Chung; Peter J Barnes
Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.
American journal of respiratory and critical care medicine 1995;151(6):1907-14.
1995: Sergei A Kharitonov; Brian J O'connor; D J Evans; Peter J Barnes
Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.
American journal of respiratory and critical care medicine 1995;151(6):1894-9.
1995: Sergei A Kharitonov; A U Wells; Brian J O'connor; Peter J Cole; David Hansell; R B Logan-Sinclair; Peter J Barnes
Elevated levels of exhaled nitric oxide in bronchiectasis.
American journal of respiratory and critical care medicine 1995;151(6):1889-93.
1995: Y H Lei; Peter J Barnes; Duncan F Rogers
Mechanisms and modulation of airway plasma exudation after direct inhalation of cigarette smoke.
American journal of respiratory and critical care medicine 1995;151(6):1752-62.
1995: Peter J Barnes
Nitric oxide and airway disease.
Annals of medicine 1995;27(3):389-93.
1995: L M Kuitert; R M Angus; N C Barnes; Peter J Barnes; M F Bone; K F Chung; A J Fairfax; T W Higenbotham; B J O'Connor; B Piotrowska
Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma.
American journal of respiratory and critical care medicine 1995;151(5):1331-5.
1995: Ian M Adcock; M J Peters; C R Brown; D A Stevens; Peter J Barnes
High concentrations of beta-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro.
Biochemical Society transactions 1995;23(2):217S.
1995: O J Kwon; Peter J Jose; R A Robbins; T J Schall; Timothy J Williams; Peter J Barnes
Glucocorticoid inhibition of RANTES expression in human lung epithelial cells.
American journal of respiratory cell and molecular biology 1995;12(5):488-96.
1995: M J Peters; Ian M Adcock; C R Brown; Peter J Barnes
Beta-adrenoceptor agonists interfere with glucocorticoid receptor DNA binding in rat lung.
European journal of pharmacology 1995;289(2):275-81.
1995: EB Haddad; Michael Salmon; J Sun; Shu Liu; A Das; Ian M Adcock; Peter J Barnes; K Fan Chung
Dexamethasone inhibits ozone-induced gene expression of macrophage inflammatory protein-2 in rat lung.
FEBS letters 1995;363(3):285-8.
1995: Ian M Adcock; S J Lane; C R Brown; M J Peters; Tak H Lee; Peter J Barnes
Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3500-5.
1995: Peter J Barnes; Brian J O'connor
Use of a fixed combination beta 2-agonist and steroid dry powder inhaler in asthma.
American journal of respiratory and critical care medicine 1995;151(4):1053-7.
1995: J Rousell; EB Haddad; Judith C W Mak; Peter J Barnes
Transcriptional down-regulation of m2 muscarinic receptor gene expression in human embryonic lung (HEL 299) cells by protein kinase C.
The Journal of biological chemistry 1995;270(13):7213-8.
1995: Peter J Barnes
Inhaled glucocorticoids for asthma.
The New England journal of medicine 1995;332(13):868-75.
1995: Peter J Barnes
Is asthma a nervous disease? The Parker B. Francis Lectureship.
Chest 1995;107(3 Suppl):119S-125S.
1995: Peter J Barnes
Cyclic nucleotides and phosphodiesterases and airway function.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(3):457-62.
1995: M Aubier; Peter J Barnes
Theophylline and phosphodiesterase inhibitors.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(3):347-8.
1995: Peter J Barnes; Shu Liu
Regulation of pulmonary vascular tone.
Pharmacological reviews 1995;47(1):87-131.
1995: H Tsukagoshi; J Sun; O Kwon; Peter J Barnes; K Fan Chung
Role of neutral endopeptidase in bronchial hyperresponsiveness to bradykinin induced by IL-1 beta.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):921-7.
1995: H Tsukagoshi; EB Haddad; J Sun; Peter J Barnes; K Fan Chung
Ozone-induced airway hyperresponsiveness: role of superoxide anions, NEP, and BK receptors.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):1015-22.
1995: J K Ward; Peter J Barnes; S Tadjkarimi; M H Yacoub; Maria G Belvisi
Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea.
The Journal of physiology 1995;483 ( Pt 2)():525-36.
1995: Peter J Barnes; F Y Liew
Nitric oxide and asthmatic inflammation.
Immunology today 1995;16(3):128-30.
1995: Sergei A Kharitonov; D Yates; David R Springall; Lee D K Buttery; J Polak; R A Robbins; Peter J Barnes
Exhaled nitric oxide is increased in asthma.
Chest 1995;107(3 Suppl):156S-157S.
1995: Stuart J Hirst; BL Webb; Mark A Giembycz; Peter J Barnes; Charles H C Twort
Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase.
American journal of respiratory cell and molecular biology 1995;12(2):149-61.
1995: Ian M Adcock; C R Brown; C M Gelder; H Shirasaki; M J Peters; Peter J Barnes
Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
The American journal of physiology 1995;268(2 Pt 1):C331-8.
1995: Sergei A Kharitonov; G Lubec; B Lubec; M Hjelm; Peter J Barnes
L-arginine increases exhaled nitric oxide in normal human subjects.
Clinical science (London, England : 1979) 1995;88(2):135-9.
1995: W Elwood; J Sun; Peter J Barnes; Mark A Giembycz; K Fan Chung
Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in brown-Norway rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44(2):83-6.
1995: Sergei A Kharitonov; D Yates; Peter J Barnes
Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(2):295-7.
1995: N K Harrison; K E Dawes; O J Kwon; Peter J Barnes; Geoffrey J Laurent; K Fan Chung
Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis.
The American journal of physiology 1995;268(2 Pt 1):L278-83.
1995: J P Hayes; H P Kuo; J A Rohde; A J Newman Taylor; Peter J Barnes; K Fan Chung; Duncan F Rogers
Neurogenic goblet cell secretion and bronchoconstriction in guinea pigs sensitised to trimellitic anhydride.
European journal of pharmacology 1995;292(2):127-34.
1995: Peter J Barnes; Maria G Belvisi; Judith C W Mak; EB Haddad; B O'Connor
Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease.
Life sciences 1995;56(11-12):853-9.
1995: Judith C W Mak; M Nishikawa; Peter J Barnes
Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung.
The American journal of physiology 1995;268(1 Pt 1):L41-6.
1995: A J Fox; Peter J Barnes; A Dray
Stimulation of guinea-pig tracheal afferent fibres by non-isosmotic and low-chloride stimuli and the effect of frusemide.
The Journal of physiology 1995;482 ( Pt 1)():179-87.
1995: Maria G Belvisi; J K Ward; J A Mitchell; Peter J Barnes
Nitric oxide as a neurotransmitter in human airways.
Archives internationales de pharmacodynamie et de thérapie 1995;329(1):97-110.
1995: Peter J Barnes
From pathophysiological mechanisms to pharmacological treatment of childhood asthma.
Pediatric pulmonology. Supplement 1995;11():40-1.
1995: X L Zhang; Judith C W Mak; Peter J Barnes
Characterization and autoradiographic mapping of [3H]CP96,345, a nonpeptide selective NK1 receptor antagonist in guinea pig lung.
Peptides 1995;16(5):867-72.
1994: G Dent; Mark A Giembycz; P M Evans; K F Rabe; Peter J Barnes
Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1167-74.
1994: T Takahashi; Maria G Belvisi; H Patel; J K Ward; S Tadjkarimi; M H Yacoub; Peter J Barnes
Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways.
American journal of respiratory and critical care medicine 1994;150(6 Pt 1):1640-5.
1994: S I Ramnarine; Y Hirayama; Peter J Barnes; Duncan F Rogers
'Sensory-efferent' neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro.
British journal of pharmacology 1994;113(4):1183-90.
1994: Ian M Adcock; C R Brown; H Shirasaki; Peter J Barnes
Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(12):2117-23.
1994: Peter J Barnes
Cytokines as mediators of chronic asthma.
American journal of respiratory and critical care medicine 1994;150(5 Pt 2):S42-9.
1994: C Kroegel; Mark A Giembycz; H Matthys; John Westwick; Peter J Barnes
Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation.
American journal of respiratory cell and molecular biology 1994;11(5):593-9.
1994: Jane A Mitchell; M G Belvisi; Pravit Akarasereenont; R A Robbins; O J Kwon; Jamie Croxtall; Peter J Barnes; JR Vane
Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone.
British journal of pharmacology 1994;113(3):1008-14.
1994: Brian J O'connor; C T Yeo; Y M Chen-Worsdell; Peter J Barnes; K Fan Chung
Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma.
Thorax 1994;49(11):1096-8.
1994: O J Kwon; B T Au; PD Collins; Ian M Adcock; Judith C W Mak; R R Robbins; K Fan Chung; Peter J Barnes
Tumor necrosis factor-induced interleukin-8 expression in cultured human airway epithelial cells.
The American journal of physiology 1994;267(4 Pt 1):L398-405.
1994: H Tsukagoshi; R A Robbins; Peter J Barnes; K Fan Chung
Role of nitric oxide and superoxide anions in interleukin-1 beta-induced airway hyperresponsiveness to bradykinin.
American journal of respiratory and critical care medicine 1994;150(4):1019-25.
1994: Judith C W Mak; B Grandordy; Peter J Barnes
High affinity [3H]formoterol binding sites in lung: characterization and autoradiographic mapping.
European journal of pharmacology 1994;269(1):35-41.
1994: Peter J Barnes
Endothelins and pulmonary diseases.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;77(3):1051-9.
1994: R A Robbins; Peter J Barnes; David R Springall; John Bowen Warren; O J Kwon; Lee D K Buttery; A J Wilson; D A Geller; Julia M Polak
Expression of inducible nitric oxide in human lung epithelial cells.
Biochemical and biophysical research communications 1994;203(1):209-18.
1994: Brian J O'connor; R W Fuller; Peter J Barnes
Nonbronchodilator effects of inhaled beta 2 agonists. Greater protection against adenosine monophosphate- than methacholine-induced bronchoconstriction in asthma.
American journal of respiratory and critical care medicine 1994;150(2):381-7.
1994: James N Baraniuk; P B Silver; M A Kaliner; Peter J Barnes
Effects of ipratropium bromide on bradykinin nasal provocation in chronic allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1994;24(8):724-9.
1994: M A Spiteri; R A Knight; J Y Jeremy; Peter J Barnes; K F Chung
Alveolar macrophage-induced suppression of peripheral blood mononuclear cell responsiveness is reversed by in vitro allergen exposure in bronchial asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(8):1431-8.
1994: H Shirasaki; Ian M Adcock; O J Kwon; M Nishikawa; Judith C W Mak; Peter J Barnes
Agonist-induced up-regulation of platelet-activating factor receptor messenger RNA in human monocytes.
European journal of pharmacology 1994;268(2):263-6.
1994: Brian J O'connor; S Uden; T J Carty; James D Eskra; Peter J Barnes; K Fan Chung
Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans.
American journal of respiratory and critical care medicine 1994;150(1):35-40.
1994: Angela Haczku; Redwan Moqbel; W Elwood; J Sun; A Barry Kay; Peter J Barnes; K Fan Chung
Effects of prolonged repeated exposure to ovalbumin in sensitized brown Norway rats.
American journal of respiratory and critical care medicine 1994;150(1):23-7.
1994: J Sun; W Elwood; Angela Haczku; Peter J Barnes; P G Hellewell; K Fan Chung
Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised brown-Norway rats.
International archives of allergy and immunology 1994;104(3):291-5.
1994: EB Haddad; Judith C W Mak; Alison A Hislop; Sheila G Haworth; Peter J Barnes
Characterization of muscarinic receptor subtypes in pig airways: radioligand binding and northern blotting studies.
The American journal of physiology 1994;266(6 Pt 1):L642-8.
1994: Peter J Barnes
Blunted perception and death from asthma.
The New England journal of medicine 1994;330(19):1383-4.
1994: EB Haddad; Judith C W Mak; Peter J Barnes
Characterization of [3H]Ba 679 BR, a slowly dissociating muscarinic antagonist, in human lung: radioligand binding and autoradiographic mapping.
Molecular pharmacology 1994;45(5):899-907.
1994: G Dent; Mark A Giembycz; K F Rabe; B Wolf; Peter J Barnes; H Magnussen
Theophylline suppresses human alveolar macrophage respiratory burst through phosphodiesterase inhibition.
American journal of respiratory cell and molecular biology 1994;10(5):565-72.
1994: H Shirasaki; M Nishikawa; Ian M Adcock; Judith C W Mak; T Sakamoto; T Shimizu; Peter J Barnes
Expression of platelet-activating factor receptor mRNA in human and guinea pig lung.
American journal of respiratory cell and molecular biology 1994;10(5):533-7.
1994: Peter J Barnes
"Epithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle".
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(5):1841-2.
1994: Peter J Barnes
Air pollution and asthma.
Postgraduate medical journal 1994;70(823):319-25.
1994: Ian M Adcock; C R Brown; Peter J Barnes
Dexamethasone action on c-fos and c-jun mRNA and protein in human lung.
Biochemical Society transactions 1994;22(2):187S.
1994: Ian M Adcock; Shu Liu; C R Brown; Timothy W Evans; Peter J Barnes
Endotoxin and steroid effects of nitric oxide synthase mRNA expression in rat lung and other tissues.
Biochemical Society transactions 1994;22(2):188S.
1994: Ian M Adcock; C R Brown; O Kwon; Peter J Barnes
Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in the human epithelial cell line A549.
Biochemical Society transactions 1994;22(2):186S.
1994: Brian J O'connor; Peter J Barnes; K Fan Chung
Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products.
Thorax 1994;49(4):307-11.
1994: Peter J Barnes
The fate of respiratory physiology.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(4):635-6.
1994: J K Ward; A J Fox; Peter J Barnes; Maria G Belvisi
Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor.
British journal of pharmacology 1994;111(4):1095-102.
1994: T Takahashi; Maria G Belvisi; Peter J Barnes
Modulation of neurotransmission in guinea-pig airways by galanin and the effect of a new antagonist galantide.
Neuropeptides 1994;26(4):245-51.
1994: Ian M Adcock; C R Brown; O Kwon; Peter J Barnes
Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells.
Biochemical and biophysical research communications 1994;199(3):1518-24.
1994: O J Kwon; B T Au; PD Collins; James N Baraniuk; Ian M Adcock; K Fan Chung; Peter J Barnes
Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells.
Immunology 1994;81(3):389-94.
1994: Peter J Barnes; R A Pauwels
Theophylline in the management of asthma: time for reappraisal?
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(3):579-91.
1994: Shu Liu; H P Kuo; M N Sheppard; Peter J Barnes; Timothy W Evans
Vagal stimulation induces increased pulmonary vascular permeability in guinea pig.
American journal of respiratory and critical care medicine 1994;149(3 Pt 1):744-50.
1994: T Sakamoto; H Tsukagoshi; Peter J Barnes; K Fan Chung
Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects.
American journal of respiratory and critical care medicine 1994;149(2 Pt 1):387-91.
1994: H Tsukagoshi; T Sakamoto; W Xu; Peter J Barnes; K Fan Chung
Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats.
The Journal of allergy and clinical immunology 1994;93(2):464-9.
1994: K F Rabe; R S Perkins; G Dent; H Gustmann; Peter J Barnes
Inhibitory effects of sulfonated shale oil fractions on the oxidative burst and Ca++ mobilization in stimulated macrophages.
Arzneimittel-Forschung 1994;44(2):166-70.
1994: Sergei A Kharitonov; D Yates; R A Robbins; R Logan-Sinclair; Elliot A Shinebourne; Peter J Barnes
Increased nitric oxide in exhaled air of asthmatic patients.
Lancet 1994;343(8890):133-5.
1994: T Sakamoto; J Sun; Peter J Barnes; K Fan Chung
Effect of a bradykinin receptor antagonist, HOE 140, against bradykinin- and vagal stimulation-induced airway responses in the guinea-pig.
European journal of pharmacology 1994;251(2-3):137-42.
1994: James N Baraniuk; P B Silver; M A Kaliner; Peter J Barnes
Perennial rhinitis subjects have altered vascular, glandular, and neural responses to bradykinin nasal provocation.
International archives of allergy and immunology 1994;103(2):202-8.
1994: M Nishikawa; Judith C W Mak; H Shirasaki; S E Harding; Peter J Barnes
Long-term exposure to norepinephrine results in down-regulation and reduced mRNA expression of pulmonary beta-adrenergic receptors in guinea pigs.
American journal of respiratory cell and molecular biology 1994;10(1):91-9.
1994: W Elwood; T Sakamoto; Peter J Barnes; K Fan Chung
Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat.
International archives of allergy and immunology 1994;103(1):67-72.
1994: Ian M Adcock; H Shirasaki; C M Gelder; M J Peters; C R Brown; Peter J Barnes
The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung.
Life sciences 1994;55(14):1147-53.
1994: B M Grandordy; Judith C W Mak; Peter J Barnes
Modulation of airway smooth muscle beta-adrenoceptor function by a muscarinic agonist.
Life sciences 1994;54(3):185-91.
1994: M G Belvisi; Riccardo Patacchini; Peter J Barnes; Carlo Alberto Maggi
Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.
British journal of pharmacology 1994;111(1):103-10.
1994: M Miura; M G Belvisi; Peter J Barnes
Modulation of nonadrenergic noncholinergic neural bronchoconstriction by bradykinin in anesthetized guinea pigs in vivo.
The Journal of pharmacology and experimental therapeutics 1994;268(1):482-6.
1993: Peter J Barnes; Ian M Adcock
Anti-inflammatory actions of steroids: molecular mechanisms.
Trends in pharmacological sciences 1993;14(12):436-41.
1993: Shu Liu; Ian M Adcock; R W Old; Peter J Barnes; Timothy W Evans
Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA.
Biochemical and biophysical research communications 1993;196(3):1208-13.
1993: M Nishikawa; Judith C W Mak; H Shirasaki; Peter J Barnes
Differential down-regulation of pulmonary beta 1- and beta 2-adrenoceptor messenger RNA with prolonged in vivo infusion of isoprenaline.
European journal of pharmacology 1993;247(2):131-8.
1993: Peter J Barnes
Asthma: what is there left to find out?
BMJ (Clinical research ed.) 1993;307(6908):814-5.
1993: F Njuki; Claire Nicholl; Alison Howard; J C Mak; Peter J Barnes; S I Girgis; Stephen Legon
A new calcitonin-receptor-like sequence in rat pulmonary blood vessels.
Clinical science (London, England : 1979) 1993;85(4):385-8.
1993: Peter J Barnes; S Pedersen
Efficacy and safety of inhaled corticosteroids in asthma. Report of a workshop held in Eze, France, October 1992.
The American review of respiratory disease 1993;148(4 Pt 2):S1-26.
1993: Peter J Barnes; M G Belvisi
Nitric oxide and lung disease.
Thorax 1993;48(10):1034-43.
1993: J Sun; W Elwood; Peter J Barnes; K Fan Chung
Effect of thiazide diuretics against neurally mediated contraction of guinea pig airways. Contribution of carbonic anhydrase.
The American review of respiratory disease 1993;148(4 Pt 1):902-8.
1993: J P Hayes; Peter J Barnes; A J Taylor; K Fan Chung
Effect of a topical corticosteroid on airway hyperresponsiveness and eosinophilic inflammation induced by trimellitic anhydride exposure in sensitized guinea pigs.
The Journal of allergy and clinical immunology 1993;92(3):450-6.
1993: A J Fox; Peter J Barnes; L Urban; A Dray
An in vitro study of the properties of single vagal afferents innervating guinea-pig airways.
The Journal of physiology 1993;469():21-35.
1993: T Sakamoto; Peter J Barnes; K Fan Chung
Effect of beta 2-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
Agents and actions 1993;40(1-2):50-6.
1993: K Miyayasu; Judith C W Mak; M Nishikawa; Peter J Barnes
Characterization of guinea pig pulmonary neurokinin type 1 receptors using a novel antagonist ligand, [3H]FK888.
Molecular pharmacology 1993;44(3):539-44.
1993: Y H Lei; Peter J Barnes; Duncan F Rogers
Inhibition of neurogenic plasma exudation and bronchoconstriction by a K+ channel activator, BRL 38227, in guinea pig airways in vivo.
European journal of pharmacology 1993;239(1-3):257-9.
1993: J K Ward; Maria G Belvisi; A J Fox; M Miura; S Tadjkarimi; M H Yacoub; Peter J Barnes
Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro.
The Journal of clinical investigation 1993;92(2):736-42.
1993: Ian M Adcock; M Peters; C Gelder; H Shirasaki; C R Brown; Peter J Barnes
Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids.
Journal of molecular endocrinology 1993;11(1):1-7.
1993: Ian M Adcock; M J Peters; C R Brown; C M Gelder; Peter J Barnes
Transcription factor interactions in human lung.
Biochemical Society transactions 1993;21 ( Pt 3)(3):277S.
1993: Peter J Barnes
Effect of nedocromil sodium on microvascular leakage.
The Journal of allergy and clinical immunology 1993;92(1 Pt 2):197-9.
1993: Peter J Barnes
Effect of nedocromil sodium on platelet-activating factor-induced airway responses.
The Journal of allergy and clinical immunology 1993;92(1 Pt 2):187-9.
1993: Peter J Barnes
Effect of nedocromil sodium on airway sensory nerves.
The Journal of allergy and clinical immunology 1993;92(1 Pt 2):182-6.
1993: W Elwood; T Sakamoto; Peter J Barnes; K Fan Chung
Allergen-induced airway hyperresponsiveness in Brown-Norway rat: role of parasympathetic mechanisms.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(1):279-84.
1993: T Sakamoto; H Tsukagoshi; Peter J Barnes; K Fan Chung
Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs.
Agents and actions 1993;39(3-4):111-7.
1993: N Watson; J Maclagan; Peter J Barnes
Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea.
British journal of pharmacology 1993;109(3):751-9.
1993: R A Stone; Peter J Barnes; K Fan Chung
Effect of frusemide on cough responses to chloride-deficient solution in normal and mild asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(6):862-7.
1993: D G McCormack; R G Rees; D Crawley; Peter J Barnes; Timothy W Evans
Sensory neuropeptides and hypoxic pulmonary vasoconstriction in the rat.
Thorax 1993;48(5):554-7.
1993: N Watson; J Maclagan; Peter J Barnes
Vagal control of guinea pig tracheal smooth muscle: lack of involvement of VIP or nitric oxide.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):1964-71.
1993: C Kroegel; A Dewar; T Yukawa; P Venge; Peter J Barnes; K Fan Chung
Ultrastructural characterization of platelet-activating factor-stimulated human eosinophils from patients with asthma.
Clinical science (London, England : 1979) 1993;84(4):391-9.
1993: Peter J Barnes
Diuretics and asthma.
Thorax 1993;48(3):195-6.
1993: T Sakamoto; W Elwood; Peter J Barnes; K Fan Chung
Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(3):1117-22.
1993: Peter J Barnes
Muscarinic receptor subtypes in airways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(3):328-31.
1993: M Miura; Maria G Belvisi; J K Ward; S Tadjkarimi; M H Yacoub; Peter J Barnes
Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro.
British journal of clinical pharmacology 1993;35(3):318-20.
1993: Peter J Barnes
Beta-adrenoceptors and asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1993;23(3):165-7.
1993: G M Verleden; Maria G Belvisi; K F Rabe; M Miura; Peter J Barnes
Beta 2-adrenoceptor agonists inhibit NANC neural bronchoconstrictor responses in vitro.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(3):1195-9.
1993: Y Hirayama; Y H Lei; Peter J Barnes; Duncan F Rogers
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
British journal of pharmacology 1993;108(3):844-51.
1993: W Elwood; J O Lötvall; Peter J Barnes; K Fan Chung
Airway hyperresponsiveness to acetylcholine and to tachykinins after respiratory virus infection in the guinea pig.
Annals of allergy 1993;70(3):231-6.
1993: M Kato; Kenichi Tokuyama; A Morikawa; T Kuroume; Peter J Barnes
Platelet-activating factor-induced enhancement of superoxide anion generation in guinea-pigs.
European journal of pharmacology 1993;232(1):7-12.
1993: K F Rabe; Mark A Giembycz; G Dent; R S Perkins; P Evans; Peter J Barnes
Salmeterol is a competitive antagonist at beta-adrenoceptors mediating inhibition of respiratory burst in guinea-pig eosinophils.
European journal of pharmacology 1993;231(2):305-8.
1993: J C Kidney; R W Fuller; Y M Worsdell; E A Lavender; K Fan Chung; Peter J Barnes
Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol.
Thorax 1993;48(2):130-3.
1993: P M Evans; B J O'Connor; R W Fuller; Peter J Barnes; K Fan Chung
Effect of inhaled corticosteroids on peripheral blood eosinophil counts and density profiles in asthma.
The Journal of allergy and clinical immunology 1993;91(2):643-50.
1993: P C Ring; Paul M Seldon; Peter J Barnes; Mark A Giembycz
Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation.
Molecular pharmacology 1993;43(2):302-12.
1993: Peter J Barnes
Nitric oxide and airways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(2):163-5.
1993: Maria G Belvisi; M Miura; D Stretton; Peter J Barnes
Endogenous vasoactive intestinal peptide and nitric oxide modulate cholinergic neurotransmission in guinea-pig trachea.
European journal of pharmacology 1993;231(1):97-102.
1993: T Sakamoto; Peter J Barnes; K Fan Chung
Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
European journal of pharmacology 1993;231(1):31-8.
1993: Peter J Barnes
Anti-inflammatory therapy for asthma.
Annual review of medicine 1993;44():229-42.
1993: Brian J O'connor; J M Lecomte; Peter J Barnes
Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma.
British journal of clinical pharmacology 1993;35(1):55-7.
1993: R A Stone; Y M Worsdell; R W Fuller; Peter J Barnes
Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(1):396-401.
1993: James N Baraniuk; K Ohkubo; O J Kwon; J Mak; J Rohde; M A Kaliner; S R Durham; Peter J Barnes
Identification of neutral endopeptidase mRNA in human nasal mucosa.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(1):272-9.
1993: Peter J Barnes
Muscarinic receptor subtypes in airways.
Life sciences 1993;52(5-6):521-7.
1993: J C Kidney; S M Ridge; K Fan Chung; Peter J Barnes
Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219.
The American review of respiratory disease 1993;147(1):215-7.
1993: Judith C W Mak; EB Haddad; N J Buckley; Peter J Barnes
Visualization of muscarinic m4 mRNA and M4 receptor subtype in rabbit lung.
Life sciences 1993;53(19):1501-8.
1993: Peter J Barnes
Beta-adrenoceptors on smooth muscle, nerves and inflammatory cells.
Life sciences 1993;52(26):2101-9.
1993: G Dent; Peter J Barnes
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Life sciences 1993;52(20):1633-40.
1993: Peter J Barnes
Muscarinic receptor subtypes: implications for therapy.
Agents and actions. Supplements 1993;43():243-52.
1993: Duncan F Rogers; Eric W F W Alton; A Dewar; M I Lethem; Peter J Barnes
Impaired stimulus-evoked mucus secretion in cystic fibrosis bronchi.
Experimental lung research 1993;19(1):37-53.
1993: Kenichi Tokuyama; T Yokoyama; A Morikawa; Hiroyuki Mochizuki; T Kuroume; Peter J Barnes
Attenuation of tachykinin-induced airflow obstruction and microvascular leakage in immature airways.
British journal of pharmacology 1993;108(1):23-9.
1993: Y H Lei; Peter J Barnes; Duncan F Rogers
Regulation of NANC neural bronchoconstriction in vivo in the guinea-pig: involvement of nitric oxide, vasoactive intestinal peptide and soluble guanylyl cyclase.
British journal of pharmacology 1993;108(1):228-35.
1992: Eric W F W Alton; Duncan F Rogers; R Logan-Sinclair; M Yacoub; Peter J Barnes; Duncan M Geddes
Bioelectric properties of cystic fibrosis airways obtained at heart-lung transplantation.
Thorax 1992;47(12):1010-4.
1992: Stuart J Hirst; Peter J Barnes; Charles H C Twort
Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor.
American journal of respiratory cell and molecular biology 1992;7(6):574-81.
1992: Peter J Barnes; T H Lee
Recent advances in asthma.
Postgraduate medical journal 1992;68(806):942-53.
1992: Maria G Belvisi; C D Stretton; M Miura; G M Verleden; S Tadjkarimi; M H Yacoub; Peter J Barnes
Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(6):2505-10.
1992: A E Tattersfield; Peter J Barnes
Beta 2-agonists and corticosteroids: new developments and controversies. Report of a meeting in November 1990.
The American review of respiratory disease 1992;146(6):1637-41.
1992: C T Yeo; Brian J O'connor; M Chen-Worsdell; Peter J Barnes; K F Chung
Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(10):1184-8.
1992: Peter J Barnes
Bradykinin and asthma.
Thorax 1992;47(11):979-83.
1992: J P Hayes; R Daniel; RD Tee; Peter J Barnes; A J Taylor; K Fan Chung
Bronchial hyperreactivity after inhalation of trimellitic anhydride dust in guinea pigs after intradermal sensitization to the free hapten.
The American review of respiratory disease 1992;146(5 Pt 1):1311-4.
1992: J P Hayes; J O Lotvall; James N Baraniuk; R Daniel; Peter J Barnes; A J Taylor; K Fan Chung
Bronchoconstriction and airway microvascular leakage in guinea pigs sensitized with trimellitic anhydride.
The American review of respiratory disease 1992;146(5 Pt 1):1306-10.
1992: J P Hayes; K F Chung; Peter J Barnes
Attenuation of platelet-activating factor induced bronchoconstriction by nedocromil sodium.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(10):1193-6.
1992: Shu Liu; D E Crawley; J A Rohde; Timothy W Evans; Peter J Barnes
Role of nitric oxide and guanosine 3',5'-cyclic monophosphate in mediating nonadrenergic, noncholinergic relaxation in guinea-pig pulmonary arteries.
British journal of pharmacology 1992;107(3):861-6.
1992: James N Baraniuk; P B Silver; M A Kaliner; Peter J Barnes
Neuropeptide Y is a vasoconstrictor in human nasal mucosa.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(5):1867-72.
1992: Brian J O'connor; S L Aikman; Peter J Barnes
Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma.
The New England journal of medicine 1992;327(17):1204-8.
1992: H P Kuo; Shu Liu; Peter J Barnes
The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways.
European journal of pharmacology 1992;221(2-3):385-8.
1992: K P Hui; J Lötvall; Duncan F Rogers; Peter J Barnes; F K Chung
Ovalbumin aerosol challenge in actively sensitized guinea pigs: relationship between airway microvascular leakage and airflow obstruction.
Allergy 1992;47(5):527-31.
1992: Peter J Barnes
New drugs for asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(9):1126-36.
1992: R A Stone; Peter J Barnes; R W Fuller
The low-chloride cough response is not inhibited by a single, high dose of aspirin.
British journal of clinical pharmacology 1992;34(4):370-2.
1992: M Miura; Maria G Belvisi; Peter J Barnes
Effect of bradykinin on airway neural responses in vitro.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(4):1537-41.
1992: T Sakamoto; W Elwood; Peter J Barnes; K Fan Chung
Pharmacological modulation of inhaled sodium metabisulphite-induced airway microvascular leakage and bronchoconstriction in the guinea-pig.
British journal of pharmacology 1992;107(2):481-7.
1992: Judith C W Mak; James N Baraniuk; Peter J Barnes
Localization of muscarinic receptor subtype mRNAs in human lung.
American journal of respiratory cell and molecular biology 1992;7(3):344-8.
1992: Brian J O'connor; S M Ridge; Peter J Barnes; R W Fuller
Greater effect of inhaled budesonide on adenosine 5'-monophosphate-induced than on sodium-metabisulfite-induced bronchoconstriction in asthma.
The American review of respiratory disease 1992;146(3):560-4.
1992: D E Crawley; L Zhao; Mark A Giembycz; Shu Liu; Peter J Barnes; R J Winter; Timothy W Evans
Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat.
The American journal of physiology 1992;263(3 Pt 1):L325-32.
1992: M Miura; Maria G Belvisi; C D Stretton; M H Yacoub; Peter J Barnes
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
The Journal of physiology 1992;455():1-15.
1992: H P Kuo; J A Rohde; Peter J Barnes; Duncan F Rogers
Cigarette smoke-induced airway goblet cell secretion: dose-dependent differential nerve activation.
The American journal of physiology 1992;263(2 Pt 1):L161-7.
1992: R Stone; Peter J Barnes; R W Fuller
Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(2):649-53.
1992: J P Hayes; J O Lotvall; Peter J Barnes; A J Newman Taylor; K Fan Chung
Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs.
British journal of pharmacology 1992;106(4):828-32.
1992: A J Woolcock; M R Sears; Peter J Barnes
Beta-agonists and death from asthma.
The New England journal of medicine 1992;327(5):354; author reply 356-7.
1992: J P Hayes; R Daniel; RD Tee; Peter J Barnes; K Fan Chung; Anthony Newman Taylor
Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(7):694-700.
1992: M Miura; Maria G Belvisi; C D Stretton; M H Yacoub; Peter J Barnes
Role of potassium channels in bronchodilator responses in human airways.
The American review of respiratory disease 1992;146(1):132-6.
1992: Peter J Barnes
Modulation of neurotransmission in airways.
Physiological reviews 1992;72(3):699-729.
1992: R S Perkins; G Dent; K Fan Chung; Peter J Barnes
The effect of anion transport inhibitors and extracellular Cl- concentration on eosinophil respiratory burst activity.
Biochemical pharmacology 1992;43(11):2480-3.
1992: W Elwood; J O Lötvall; Peter J Barnes; K Fan Chung
Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown-Norway rats.
The American review of respiratory disease 1992;145(6):1289-94.
1992: Peter J Barnes
PAF, eosinophils and asthma.
Journal of lipid mediators 1992;5(2):155-8.
1992: Peter J Barnes
Poorly perceived asthma.
Thorax 1992;47(6):408-9.
1992: Shu Liu; Alison A Hislop; Sheila G Haworth; Peter J Barnes
Developmental changes in endothelium-dependent pulmonary vasodilatation in pigs.
British journal of pharmacology 1992;106(2):324-30.
1992: J Lötvall; W Elwood; K Tokuyama; T Sakamoto; Peter J Barnes; K Fan Chung
A thromboxane mimetic, U-46619, produces plasma exudation in airways of the guinea pig.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(6):2415-9.
1992: T R Bai; J C Mak; Peter J Barnes
A comparison of beta-adrenergic receptors and in vitro relaxant responses to isoproterenol in asthmatic airway smooth muscle.
American journal of respiratory cell and molecular biology 1992;6(6):647-51.
1992: Maria G Belvisi; M Miura; D Stretton; Peter J Barnes
Capsazepine as a selective antagonist of capsaicin-induced activation of C-fibres in guinea-pig bronchi.
European journal of pharmacology 1992;215(2-3):341-4.
1992: H P Kuo; J A Rohde; Peter J Barnes; Duncan F Rogers
K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea.
European journal of pharmacology 1992;215(2-3):297-9.
1992: Peter J Barnes
New aspects of asthma.
Journal of internal medicine 1992;231(5):453-61.
1992: R P Daniele; Peter J Barnes; E J Goetzl; J Nadel; S O'Dorisio; J Kiley; T Jacobs
NHLBI workshop summaries. Neuroimmune interactions in the lung.
The American review of respiratory disease 1992;145(5):1230-5.
1992: James N Baraniuk; P B Silver; M A Kaliner; Peter J Barnes
Ibuprofen augments bradykinin-induced glycoconjugate secretion by human nasal mucosa in vivo.
The Journal of allergy and clinical immunology 1992;89(5):1032-9.
1992: P G Ventresca; G M Nichol; Peter J Barnes; K Fan Chung
Effect of frusemide on the induction and potentiation of cough induced by prostaglandin F2 alpha.
British journal of clinical pharmacology 1992;33(5):514-6.
1992: K P Hui; P Ventresca; A C Brown; Peter J Barnes; K Fan Chung
Modulation of neurally mediated airway microvascular leakage in guinea-pig airways by beta 2-adrenoceptor agonists.
Agents and actions 1992;36(1-2):29-32.
1992: Peter J Barnes
Molecular biology of receptors.
The Quarterly journal of medicine 1992;83(301):339-53.
1992: Hirokazu Arakawa; Kenichi Tokuyama; T Yokoyama; Hiroyuki Mochizuki; A Morikawa; T Kuroume; Peter J Barnes
Effect of maturation on histamine-induced airflow obstruction and airway microvascular leakage in guinea pig airways.
European journal of pharmacology 1992;215(1):51-6.
1992: D E Crawley; Shu Liu; Peter J Barnes; Timothy W Evans
Endothelin-3 is a potent pulmonary vasodilator in the rat.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(4):1425-31.
1992: T Sakamoto; W Elwood; Peter J Barnes; K Fan Chung
Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.
European journal of pharmacology 1992;213(3):367-73.
1992: B P Madden; Margaret E Hodson; M H Yacoub; E W Alton; Peter J Barnes; D M Denison; A B Kay; Anthony Newman Taylor; Duncan M Geddes
Heart-lung transplantation for cystic fibrosis.
BMJ (Clinical research ed.) 1992;304(6830):835-6.
1992: Shu Liu; A Dewar; D E Crawley; Peter J Barnes; Timothy W Evans
Effect of tumor necrosis factor on hypoxic pulmonary vasoconstriction.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(3):1044-9.
1992: G H Parsons; G M Nichol; Peter J Barnes; K Fan Chung
Peptide mediator effects on bronchial blood velocity and lung resistance in conscious sheep.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(3):1118-22.
1992: D G McCormack; D E Crawley; Peter J Barnes; Timothy W Evans
Bleomycin-induced lung injury in rats selectively abolishes hypoxic pulmonary vasoconstriction: evidence against a role for platelet-activating factor.
Clinical science (London, England : 1979) 1992;82(3):259-64.
1992: Maria G Belvisi; C D Stretton; G M Verleden; S J Ledingham; M H Yacoub; Peter J Barnes
Inhibition of cholinergic neurotransmission in human airways by opioids.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(3):1096-100.
1992: P M Henson; Peter J Barnes; S P Banks-Schlegel
NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities.
The American review of respiratory disease 1992;145(3):726-31.
1992: D Stretton; Maria G Belvisi; Peter J Barnes
The effect of sensory nerve depletion on cholinergic neurotransmission in guinea pig airways.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1073-80.
1992: D Stretton; M Miura; Maria G Belvisi; Peter J Barnes
Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1325-9.
1992: Shu Liu; D E Crawley; Timothy W Evans; Peter J Barnes
Endothelium-dependent nonadrenergic, noncholinergic neural relaxation in guinea pig pulmonary artery.
The Journal of pharmacology and experimental therapeutics 1992;260(2):541-8.
1992: Piera Boschetto; F G Musajo; L Tognetto; M Boscaro; Cristina E Mapp; Peter J Barnes; Leonardo M Fabbri
Increase in vascular permeability produced in rat airways by PAF: potentiation by adrenalectomy.
British journal of pharmacology 1992;105(2):388-92.
1992: H P Kuo; J A Rohde; Peter J Barnes; Duncan F Rogers
Differential inhibitory effects of opioids on cigarette smoke, capsaicin and electrically-induced goblet cell secretion in guinea-pig trachea.
British journal of pharmacology 1992;105(2):361-6.
1992: Y H Lei; Peter J Barnes; Duncan F Rogers
Inhibition of neurogenic plasma exudation in guinea-pig airways by CP-96,345, a new non-peptide NK1 receptor antagonist.
British journal of pharmacology 1992;105(2):261-2.
1992: J W Lammers; Peter J Barnes; K F Chung
Nonadrenergic, noncholinergic airway inhibitory nerves.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(2):239-46.
1992: Maria G Belvisi; C D Stretton; M Yacoub; Peter J Barnes
Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans.
European journal of pharmacology 1992;210(2):221-2.
1992: James N Baraniuk; P B Silver; J D Lundgren; P Cole; M A Kaliner; Peter J Barnes
Bombesin stimulates human nasal mucous and serous cell secretion in vivo.
The American journal of physiology 1992;262(1 Pt 1):L48-52.
1992: K Fan Chung; Peter J Barnes
Role of inflammatory mediators in asthma.
British medical bulletin 1992;48(1):135-48.
1992: N Watson; Peter J Barnes; J Maclagan
Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro.
British journal of pharmacology 1992;105(1):107-12.
1992: J Lötvall; K Rabe; K Tokuyama; Claes-Göran AH Löfdahl; Peter J Barnes; K Fan Chung
Neutrophil influx into guinea-pig airway lumen during cholinergic and non-cholinergic bronchoconstriction.
Acta physiologica Scandinavica 1992;144(1):101-6.
1992: K Fan Chung; Peter J Barnes
Loop diuretics and asthma.
Pulmonary pharmacology 1992;5(1):1-7.
1992: W Elwood; Peter J Barnes; K Fan Chung
Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic brown-Norway rats.
International archives of allergy and immunology 1992;99(1):91-7.
1992: Peter J Barnes
Effect of bradykinin on airway function.
Agents and actions. Supplements 1992;38 ( Pt 3)():432-8.
1992: G M Nichol; Brian J O'connor; J M Lecomte; K Fan Chung; Peter J Barnes
Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects.
European journal of clinical pharmacology 1992;42(5):491-4.
1992: Peter J Barnes
Asthma. New therapeutic approaches.
British medical bulletin 1992;48(1):231-47.
1992: Peter J Barnes
Neural mechanisms in asthma.
British medical bulletin 1992;48(1):149-68.
1992: Peter J Barnes
Neurogenic inflammation and asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma 1992;29(3):165-80.
1992: Peter J Barnes; K F Chung
Questions about inhaled beta 2-adrenoceptor agonists in asthma.
Trends in pharmacological sciences 1992;13(1):20-3.
1992: K F Rabe; Mark A Giembycz; G Dent; Peter J Barnes
Activation of guinea pig eosinophil respiratory burst by leukotriene B4: role of protein kinase C.
Fundamental & clinical pharmacology 1992;6(8-9):353-8.
1991: K Fan Chung; Peter J Barnes
Role for platelet-activating factor in asthma.
Lipids 1991;26(12):1277-9.
1991: W Elwood; J O Lötvall; Peter J Barnes; K Fan Chung
Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized brown-Norway rats.
The Journal of allergy and clinical immunology 1991;88(6):951-60.
1991: Peter J Barnes; James N Baraniuk; Maria G Belvisi
Neuropeptides in the respiratory tract. Part II.
The American review of respiratory disease 1991;144(6):1391-9.
1991: J O Lötvall; W Elwood; K Tokuyama; Peter J Barnes; K Fan Chung
Differential effects of phosphoramidon on neurokinin A- and substance P-induced airflow obstruction and airway microvascular leakage in guinea-pig.
British journal of pharmacology 1991;104(4):945-9.
1991: K Tokuyama; J O Lötvall; A Morikawa; Peter J Barnes; K Fan Chung
Role of thromboxane A2 in airway microvascular leakage induced by inhaled platelet-activating factor.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(5):1729-34.
1991: Q Hamid; Maria G Belvisi; D Stretton; J Rohde; A J Harmar; Peter J Barnes
Localization of beta pre-protachykinin mRNA in nodose ganglion.
Neuropeptides 1991;20(3):145-50.
1991: Peter J Barnes; James N Baraniuk; Maria G Belvisi
Neuropeptides in the respiratory tract. Part I.
The American review of respiratory disease 1991;144(5):1187-98.
1991: A Shock; K F Rabe; G Dent; Rachel C Chambers; A J Gray; K Fan Chung; Peter J Barnes; Geoffrey J Laurent
Eosinophils adhere to and stimulate replication of lung fibroblasts 'in vitro'.
Clinical and experimental immunology 1991;86(1):185-90.
1991: Peter J Barnes
Biochemistry of asthma.
Trends in biochemical sciences 1991;16(10):365-9.
1991: Shu Liu; D E Crawley; Timothy W Evans; Peter J Barnes
Endogenous nitric oxide modulates adrenergic neural vasoconstriction in guinea-pig pulmonary artery.
British journal of pharmacology 1991;104(2):565-9.
1991: J M Morgan; D G McCormack; M J Griffiths; C J Morgan; Peter J Barnes; T W Evans
Adenosine as a vasodilator in primary pulmonary hypertension.
Circulation 1991;84(3):1145-9.
1991: Peter J Barnes
Preventative therapy in adults with asthma.
Respiratory medicine 1991;85(5):355-7.
1991: J O Lötvall; K Tokuyama; Peter J Barnes; K Fan Chung
Bradykinin-induced airway microvascular leakage is potentiated by captopril and phosphoramidon.
European journal of pharmacology 1991;200(2-3):211-7.
1991: Mark A Giembycz; Peter J Barnes
Selective inhibition of a high affinity type IV cyclic AMP phosphodiesterase in bovine trachealis by AH 21-132. Relevance to the spasmolytic and anti-spasmogenic actions of AH 21-132 in the intact tissue.
Biochemical pharmacology 1991;42(3):663-77.
1991: Maria G Belvisi; C D Stretton; Peter J Barnes
Bombesin-induced bronchoconstriction in the guinea pig: mode of action.
The Journal of pharmacology and experimental therapeutics 1991;258(1):36-41.
1991: J P Hayes; S M Ridge; S Griffith; Peter J Barnes; K Fan Chung
Inhibition of cutaneous and platelet responses to platelet-activating factor by oral WEB 2086 in man.
The Journal of allergy and clinical immunology 1991;88(1):83-8.
1991: C Kroegel; E R Chilvers; Mark A Giembycz; R A Challiss; Peter J Barnes
Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: relationship to calcium mobilization and degranulation.
The Journal of allergy and clinical immunology 1991;88(1):114-24.
1991: Maria G Belvisi; D Stretton; Peter J Barnes
Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways.
European journal of pharmacology 1991;198(2-3):219-21.
1991: K Tokuyama; J O Lötvall; Peter J Barnes; K Fan Chung
Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage.
The American review of respiratory disease 1991;143(6):1345-9.
1991: W Elwood; J O Lötvall; Peter J Barnes; K Fan Chung
Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways.
The American review of respiratory disease 1991;143(6):1340-4.
1991: Brian J O'connor; K Fan Chung; Y M Chen-Worsdell; R W Fuller; Peter J Barnes
Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects.
The American review of respiratory disease 1991;143(6):1329-33.
1991: Jan Lötvall; K Tokuyama; Claes-Göran AH Löfdahl; A Ullman; Peter J Barnes; K Fan Chung
Peptidase modulation of noncholinergic vagal bronchoconstriction and airway microvascular leakage.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(6):2730-5.
1991: G Dent; Mark A Giembycz; K F Rabe; Peter J Barnes
Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors.
British journal of pharmacology 1991;103(2):1339-46.
1991: K P Hui; J Lötvall; K Fan Chung; Peter J Barnes
Attenuation of inhaled allergen-induced airway microvascular leakage and airflow obstruction in guinea pigs by a 5-lipoxygenase inhibitor (A-63162).
The American review of respiratory disease 1991;143(5 Pt 1):1015-9.
1991: Edwin R Chilvers; I H Batty; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle.
The Biochemical journal 1991;275 ( Pt 2)():373-9.
1991: P Boschetto; Duncan F Rogers; L M Fabbri; Peter J Barnes
Corticosteroid inhibition of airway microvascular leakage.
The American review of respiratory disease 1991;143(3):605-9.
1991: K P Hui; I K Taylor; G W Taylor; P Rubin; J Kesterson; N C Barnes; Peter J Barnes
Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients.
Thorax 1991;46(3):184-9.
1991: J O Lötvall; W Elwood; K Tokuyama; Peter J Barnes; K Fan Chung
Plasma exudation into airways induced by inhaled platelet-activating factor: effect of peptidase inhibition.
Clinical science (London, England : 1979) 1991;80(3):241-7.
1991: K Fan Chung; M R Podgorski; N J Goulding; J L Godolphin; P R Sharland; B O'Connor; Roderick J Flower; Peter J Barnes
Circulating autoantibodies to recombinant lipocortin-1 in asthma.
Respiratory medicine 1991;85(2):121-4.
1991: C D Stretton; Maria G Belvisi; Peter J Barnes
Modulation of neural bronchoconstrictor responses in the guinea pig respiratory tract by vasoactive intestinal peptide.
Neuropeptides 1991;18(3):149-57.
1991: Peter J Barnes
Neuropeptides and asthma.
The American review of respiratory disease 1991;143(3 Pt 2):S28-32.
1991: Judith C W Mak; Peter J Barnes
Autoradiographic visualization of bradykinin receptors in human and guinea pig lung.
European journal of pharmacology 1991;194(1):37-43.
1991: Q A Hamid; J C Mak; M N Sheppard; B Corrin; J C Venter; Peter J Barnes
Localization of beta 2-adrenoceptor messenger RNA in human and rat lung using in situ hybridization: correlation with receptor autoradiography.
European journal of pharmacology 1991;206(2):133-8.
1991: J O Lötvall; K P Hui; Claes-Göran AH Löfdahl; Peter J Barnes; K Fan Chung
Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig.
Allergy 1991;46(2):105-8.
1991: K Tokuyama; J O Lötvall; Claes-Göran AH Löfdahl; Peter J Barnes; K Fan Chung
Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage.
European journal of pharmacology 1991;193(1):35-9.
1991: Peter J Barnes
Molecular biology. Inflammatory activities.
Nature 1991;349(6307):284-5.
1991: Shu Liu; D E Crawley; Peter J Barnes; Timothy W Evans
Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats.
The American review of respiratory disease 1991;143(1):32-7.
1991: Peter J Barnes
Sensory nerves, neuropeptides, and asthma.
Annals of the New York Academy of Sciences 1991;629():359-70.
1991: Peter J Barnes
Neurogenic inflammation in airways.
International archives of allergy and applied immunology 1991;94(1-4):303-9.