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Melvyn Little

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Raksha Khusal; Stefan Knackmuss; Melvyn Little; Kiashanee Moodley; Clement Penny; Uwe Reusch; Bianca Da Costa Dias; Stefan F T Weiss
In vitro inhibition of angiogenesis by antibodies directed against the 37kDa/67kDa laminin receptor.
Aadilah Omar; Uwe Reusch; Stefan Knackmuss; Melvyn Little; Stefan F T Weiss
Anti-LRP/LR-specific antibody IgG1-iS18 significantly reduces adhesion and invasion of metastatic lung, cervix, colon and prostate cancer cells.
Matthias Eder; Stefan Knackmuss; Fabrice Le Gall; Uwe Reusch; Vladimir Rybin; Melvyn Little; Uwe Haberkorn; Walter Mier; Michael Eisenhut
68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours.

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All Publications

2013: Raksha Khusal; Stefan Knackmuss; Melvyn Little; Kiashanee Moodley; Clement Penny; Uwe Reusch; Bianca Da Costa Dias; Stefan F T Weiss
In vitro inhibition of angiogenesis by antibodies directed against the 37kDa/67kDa laminin receptor.
PloS one 2013;8(3):e58888.
2012: Aadilah Omar; Uwe Reusch; Stefan Knackmuss; Melvyn Little; Stefan F T Weiss
Anti-LRP/LR-specific antibody IgG1-iS18 significantly reduces adhesion and invasion of metastatic lung, cervix, colon and prostate cancer cells.
Journal of molecular biology 2012;419(1-2):102-9.
2010: Matthias Eder; Stefan Knackmuss; Fabrice Le Gall; Uwe Reusch; Vladimir Rybin; Melvyn Little; Uwe Haberkorn; Walter Mier; Michael Eisenhut
68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours.
European journal of nuclear medicine and molecular imaging 2010;37(7):1397-407.
2008: Matthias Eder; Björn Wängler; Stefan Knackmuss; Fabrice LeGall; Melvyn Little; Uwe Haberkorn; Walter Mier; Michael Eisenhut
Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies.
European journal of nuclear medicine and molecular imaging 2008;35(10):1878-86.
2008: Chantal Zuber; Gerda Mitteregger; Natascha Schuhmann; Clémence Rey; Stefan Knackmuss; Wolfgang Rupprecht; Uwe Reusch; Claudia Pace; Melvyn Little; Hans A Kretzschmar; Michael Hallek; Hildegard Büning; Stefan Weiss
Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy.
The Journal of general virology 2008;89(Pt 8):2055-61.
2008: Chantal Zuber; Stefan Knackmuss; Georgeta Zemora; Uwe Reusch; Ekaterina Vlasova; Daniela Diehl; Vera Mick; Karin Hoffmann; Daphne Nikles; Thomas Fröhlich; Georg J Arnold; Bertram Brenig; Eckhard Wolf; Harald Lahm; Melvyn Little; Stefan Weiss
Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor.
Journal of molecular biology 2008;378(3):530-9.
2008: Chantal Zuber; Stefan Knackmuss; Clémence Rey; Uwe Reusch; Peter Röttgen; Thomas Fröhlich; Georg J Arnold; Claudia Pace; Gerda Mitteregger; Hans A Kretzschmar; Melvyn Little; Stefan Weiss
Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases.
Molecular immunology 2008;45(1):144-51.
2004: Uwe Reusch; Fabrice Le Gall; Manfred Hensel; Gerhard Moldenhauer; Anthony D Ho; Melvyn Little; Sergey M Kipriyanov
Effect of tetravalent bispecific CD19xCD3 recombinant antibody construct and CD28 costimulation on lysis of malignant B cells from patients with chronic lymphocytic leukemia by autologous T cells.
International journal of cancer. Journal international du cancer 2004;112(3):509-18.
2004: Meike Schwarz; Peter Röttgen; Yoshiazuku Takada; Fabrice Le Gall; Stefan Knackmuss; Nicole Bassler; Claudia Büttner; Melvyn Little; Christoph Bode; Karlheinz Peter
Single-chain antibodies for the conformation-specific blockade of activated platelet integrin alphaIIbbeta3 designed by subtractive selection from naive human phage libraries.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1704-6.
2004: Jana Schlenzka; Thomas Moehler; Sergey M Kipriyanov; Martin Kornacker; Axel Benner; Alexandra Bähre; Marike J J G Stassar; Holger J Schäfer; Melvyn Little; Hartmut Goldschmidt; Björn Cochlovius
Combined effect of recombinant CD19 x CD16 diabody and thalidomide in a preclinical model of human B cell lymphoma.
Anti-cancer drugs 2004;15(9):915-9.
2004: Fabrice Le Gall; Uwe Reusch; Melvyn Little; Sergey M Kipriyanov
Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody.
Protein engineering, design & selection : PEDS 2004;17(4):357-66.
2004: Fabrice Le Gall; Uwe Reusch; Gerhard Moldenhauer; Melvyn Little; Sergey M Kipriyanov
Immunosuppressive properties of anti-CD3 single-chain Fv and diabody.
Journal of immunological methods 2004;285(1):111-27.
2003: Marie-Josée Jacobin; R Robert; O Pouns; Jeanny Laroche-Traineau; Alan Nurden; K Peter; Melvyn Little; Gisèle Clofent-Sanchez
Improving selection of alphaIIbbeta3-binding phage antibodies with increased reactivity derived from immunized donors.
Clinical immunology (Orlando, Fla.) 2003;108(3):199-210.
2003: Sergey M Kipriyanov; Gerhard Moldenhauer; Michael Braunagel; Uwe Reusch; Björn Cochlovius; Fabrice Le Gall; Olga A Kouprianova; Claus-W von der Lieth; Melvyn Little
Effect of domain order on the activity of bacterially produced bispecific single-chain Fv antibodies.
Journal of molecular biology 2003;330(1):99-111.
2002: Sergey M Kipriyanov; Björn Cochlovius; Holger J Schäfer; Gerhard Moldenhauer; Alexandra Bähre; Fabrice Le Gall; Stefan Knackmuss; Melvyn Little
Synergistic antitumor effect of bispecific CD19 x CD3 and CD19 x CD16 diabodies in a preclinical model of non-Hodgkin's lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):137-44.
2002: Marie-Josée Jacobin; Jeanny Laroche-Traineau; Melvyn Little; Armin Keller; Karlheinz Peter; Martin Welschof; Alan Nurden; Gisèle Clofent-Sanchez
Human IgG monoclonal anti-alpha(IIb)beta(3)-binding fragments derived from immunized donors using phage display.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):2035-45.
2002: Ingrid Choi; Wolfgang E Schmitt; Alexandra Bähre; Melvyn Little; Björn Cochlovius
Recombinant chimeric OKT3/IgM antibodies for immune suppression: evaluation in a human CD3 transgenic mouse model.
Immunology letters 2002;80(2):125-8.
2001: W E Schmitt; Marike J J G Stassar; Wolfgang E Schmitt; Melvyn Little; Björn Cochlovius
In vitro induction of a bladder cancer-specific T-cell response by mRNA-transfected dendritic cells.
Journal of cancer research and clinical oncology 2001;127(3):203-6.
2001: I Choi; C De Ines; T Kürschner; Björn Cochlovius; V Sörensen; T Olafsen; Inger Sandlie; Melvyn Little
Recombinant chimeric OKT3 scFv IgM antibodies mediate immune suppression while reducing T cell activation in vitro.
European journal of immunology 2001;31(1):94-106.
2000: C de Inés; Björn Cochlovius; S Schmidt; Melvyn Little
A cell surface-displayed anti-c-myc single-chain antibody: new perspectives for the genetic improvement of cellular tumor vaccines.
Cancer gene therapy 2000;7(9):1257-62.
2000: Björn Cochlovius; Sergey M Kipriyanov; Marike J J G Stassar; Jochen Schuhmacher; Axel Benner; Gerhard Moldenhauer; Melvyn Little
Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation.
Cancer research 2000;60(16):4336-41.
2000: Melvyn Little; Sergey M Kipriyanov; Fabrice Le Gall; Gerhard Moldenhauer
Of mice and men: hybridoma and recombinant antibodies.
Immunology today 2000;21(8):364-70.
2000: Björn Cochlovius; Sergey M Kipriyanov; Marike J J G Stassar; Oliver Christ; Jochen Schuhmacher; Gudrun Strauss; Gerhard Moldenhauer; Melvyn Little
Treatment of human B cell lymphoma xenografts with a CD3 x CD19 diabody and T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):888-95.
1999: Melvyn Little; Martin Welschof; Michael Braunagel; I Hermes; Christiane Christ; Armin Keller; P Rohrbach; T Kürschner; S Schmidt; Christian Kleist; Peter Terness
Generation of a large complex antibody library from multiple donors.
Journal of immunological methods 1999;231(1-2):3-9.
1999: Michaela A E Arndt; Jürgen Krauss; Sergey M Kipriyanov; Michael Pfreundschuh; Melvyn Little
A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin's tumors.
Blood 1999;94(8):2562-8.
1999: Sergey M Kipriyanov; Gerhard Moldenhauer; Jochen Schuhmacher; Björn Cochlovius; Claus-W von der Lieth; E R Matys; Melvyn Little
Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics.
Journal of molecular biology 1999;293(1):41-56.
1999: C de Inés; Björn Cochlovius; S Schmidt; Sergey M Kipriyanov; H J Rode; Melvyn Little
Apoptosis of a human melanoma cell line specifically induced by membrane-bound single-chain antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3948-56.
1999: Sergey M Kipriyanov; Melvyn Little
Generation of recombinant antibodies.
Molecular biotechnology 1999;12(2):173-201.
1999: Fabrice Le Gall; Sergey M Kipriyanov; Gerhard Moldenhauer; Melvyn Little
Di-, tri- and tetrameric single chain Fv antibody fragments against human CD19: effect of valency on cell binding.
FEBS letters 1999;453(1-2):164-8.
1999: H J Rode; U Moebius; Melvyn Little
T cell activation by monoclonal antibodies bound to tumor cells by a cell surface displayed single-chain antibody.
Journal of immunological methods 1999;224(1-2):151-60.
1999: Martin Welschof; Ulrich Reineke; Christian Kleist; Sergey M Kipriyanov; Melvyn Little; Rudolf Volkmer-Engert; Jens Schneider-Mergener; Gerhard Opelz; Peter Terness
The antigen binding domain of non-idiotypic human anti-F(ab')2 autoantibodies: study of their interaction with IgG hinge region epitopes.
Human immunology 1999;60(4):282-90.
1999: S Schmidt; Michael Braunagel; T Kürschner; Melvyn Little
Selection of an anti-CD20, single-chain antibody by phage ELISA on fixed cells.
BioTechniques 1999;26(4):697-702.
1998: M Mersmann; A Schmidt; M Tesar; A Schöneberg; Martin Welschof; Sergey M Kipriyanov; Peter Terness; Melvyn Little; Klaus Pfizenmaier; Dieter Moosmayer
Monitoring of scFv selected by phage display using detection of scFv-pIII fusion proteins in a microtiter scale assay.
Journal of immunological methods 1998;220(1-2):51-8.
1998: Sergey M Kipriyanov; Gerhard Moldenhauer; Gudrun Strauss; Melvyn Little
Bispecific CD3 x CD19 diabody for T cell-mediated lysis of malignant human B cells.
International journal of cancer. Journal international du cancer 1998;77(5):763-72.
1998: S Rondot; KG Anthony; Stefan Dübel; N Ida; Stefan Wiemann; Konrad Beyreuther; Laura S Frost; Melvyn Little; Frank Breitling
Epitopes fused to F-pilin are incorporated into functional recombinant pili.
Journal of molecular biology 1998;279(3):589-603.
1998: Melvyn Little; Stefan Dübel; Sergey M Kipriyanov; Frank Breitling
Recent developments in antibody engineering.
Methods in molecular medicine 1998;13():555-80.
1997: Michael Braunagel; Melvyn Little
Construction of a semisynthetic antibody library using trinucleotide oligos.
Nucleic acids research 1997;25(22):4690-1.
1997: B Brocks; H J Rode; M Klein; Elke Gerlach; S Dübel; Melvyn Little; Klaus Pfizenmaier; Dieter Moosmayer
A TNF receptor antagonistic scFv, which is not secreted in mammalian cells, is expressed as a soluble mono- and bivalent scFv derivative in insect cells.
Immunotechnology : an international journal of immunological engineering 1997;3(3):173-84.
1997: H Dörsam; P Rohrbach; T Kürschner; Sergey M Kipriyanov; S Renner; Michael Braunagel; Martin Welschof; Melvyn Little
Antibodies to steroids from a small human naive IgM library.
FEBS letters 1997;414(1):7-13.
1997: Peter Terness; Martin Welschof; Gerhard Moldenhauer; M Jung; L Moroder; Frank Kirchhoff; Sergey M Kipriyanov; Melvyn Little; Gerhard Opelz
Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells.
Human immunology 1997;56(1-2):17-27.
1997: M Zewe; Susanna M Rybak; Stefan Dübel; Johannes F Coy; Martin Welschof; Dianne L Newton; Melvyn Little
Cloning and cytotoxicity of a human pancreatic RNase immunofusion.
Immunotechnology : an international journal of immunological engineering 1997;3(2):127-36.
1997: P Fuchs; Frank Breitling; Melvyn Little; Stefan Dübel
Primary structure and functional scFv antibody expression of an antibody against the human protooncogen c-myc.
Hybridoma 1997;16(3):227-33.
1997: Sergey M Kipriyanov; Gerhard Moldenhauer; A C Martin; O A Kupriyanova; Melvyn Little
Two amino acid mutations in an anti-human CD3 single chain Fv antibody fragment that affect the yield on bacterial secretion but not the affinity.
Protein engineering 1997;10(4):445-53.
1997: Martin Welschof; Peter Terness; Sergey M Kipriyanov; D Stanescu; Frank Breitling; H Dörsam; Stefan Dübel; Melvyn Little; Gerhard Opelz
The antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1902-7.
1997: Sergey M Kipriyanov; Gerhard Moldenhauer; Melvyn Little
High level production of soluble single chain antibodies in small-scale Escherichia coli cultures.
Journal of immunological methods 1997;200(1-2):69-77.
1997: Sergey M Kipriyanov; Melvyn Little
Affinity purification of tagged recombinant proteins using immobilized single chain Fv fragments.
Analytical biochemistry 1997;244(1):189-91.
1996: H J Rode; Melvyn Little; P Fuchs; H Dörsam; H Schooltink; C de Inés; Stefan Dübel; Frank Breitling
Cell surface display of a single-chain antibody for attaching polypeptides.
BioTechniques 1996;21(4):650, 652-3, 655-6, 658.
1996: Sergey M Kipriyanov; O A Kupriyanova; Melvyn Little; Gerhard Moldenhauer
Rapid detection of recombinant antibody fragments directed against cell-surface antigens by flow cytometry.
Journal of immunological methods 1996;196(1):51-62.
1996: P Fuchs; W Weichel; Stefan Dübel; Frank Breitling; Melvyn Little
Separation of E. coli expressing functional cell-wall bound antibody fragments by FACS.
Immunotechnology : an international journal of immunological engineering 1996;2(2):97-102.
1996: Sergey M Kipriyanov; Melvyn Little; H Kropshofer; Frank Breitling; S Gotter; Stefan Dübel
Affinity enhancement of a recombinant antibody: formation of complexes with multiple valency by a single-chain Fv fragment-core streptavidin fusion.
Protein engineering 1996;9(2):203-11.
1995: Melvyn Little; Frank Breitling; Stefan Dübel; P Fuchs; Michael Braunagel
Human antibody libraries in Escherichia coli.
Journal of biotechnology 1995;41(2-3):187-95.
1995: N Hayashi; Sergey M Kipriyanov; P Fuchs; Martin Welschof; H Dörsam; Melvyn Little
A single expression system for the display, purification and conjugation of single-chain antibodies.
Gene 1995;160(1):129-30.
1995: Sergey M Kipriyanov; Stefan Dübel; Frank Breitling; Roland Kontermann; Stephan Heymann; Melvyn Little
Bacterial expression and refolding of single-chain Fv fragments with C-terminal cysteines.
Cell biophysics 1995;26(3):187-204.
1995: Dieter Moosmayer; Stefan Dübel; B Brocks; H Watzka; C Hampp; Peter Scheurich; Melvyn Little; Klaus Pfizenmaier
A single-chain TNF receptor antagonist is an effective inhibitor of TNF mediated cytotoxicity.
Therapeutic immunology 1995;2(1):31-40.
1995: Stefan Dübel; Frank Breitling; Roland Kontermann; T Schmidt; A Skerra; Melvyn Little
Bifunctional and multimeric complexes of streptavidin fused to single chain antibodies (scFv).
Journal of immunological methods 1995;178(2):201-9.
1995: Sergey M Kipriyanov; Frank Breitling; Melvyn Little; Stefan Dübel
Single-chain antibody streptavidin fusions: tetrameric bifunctional scFv-complexes with biotin binding activity and enhanced affinity to antigen.
Human antibodies and hybridomas 1995;6(3):93-101.
1994: Sergey M Kipriyanov; Stefan Dübel; Frank Breitling; Roland Kontermann; Melvyn Little
Recombinant single-chain Fv fragments carrying C-terminal cysteine residues: production of bivalent and biotinylated miniantibodies.
Molecular immunology 1994;31(14):1047-58.
1994: Stefan Dübel; Frank Breitling; P Fuchs; M Zewe; S Gotter; Martin Welschof; Gerhard Moldenhauer; Melvyn Little
Isolation of IgG antibody Fv-DNA from various mouse and rat hybridoma cell lines using the polymerase chain reaction with a simple set of primers.
Journal of immunological methods 1994;175(1):89-95.
1994: N Hayashi; Martin Welschof; M Zewe; Michael Braunagel; Stefan Dübel; Frank Breitling; Melvyn Little
Simultaneous mutagenesis of antibody CDR regions by overlap extension and PCR.
BioTechniques 1994;17(2):310, 312, 314-5.
1994: Burkhard Micheel; Stephan Heymann; G Scharte; V Böttger; F Vogel; Stefan Dübel; Frank Breitling; Melvyn Little; Olaf Behrsing
Production of monoclonal antibodies against epitopes of the main coat protein of filamentous fd phages.
Journal of immunological methods 1994;171(1):103-9.
1994: Melvyn Little; Frank Breitling; Burkhard Micheel; Stefan Dübel
Surface display of antibodies.
Biotechnology advances 1994;12(3):539-55.
1993: Stefan Dübel; Frank Breitling; P Fuchs; Michael Braunagel; I Klewinghaus; Melvyn Little
A family of vectors for surface display and production of antibodies.
Gene 1993;128(1):97-101.
1993: Melvyn Little; Frank Breitling; Stefan Dübel; P Fuchs; Michael Braunagel; T Seehaus; I Klewinghaus
Universal antibody libraries on phage and bacteria.
The Year in immunology 1993;7():50-5.
1993: Melvyn Little; P Fuchs; Frank Breitling; Stefan Dübel
Bacterial surface presentation of proteins and peptides: an alternative to phage technology?
Trends in biotechnology 1993;11(1):3-5.
1992: P Fuchs; Stefan Dübel; Frank Breitling; Michael Braunagel; I Klewinghaus; Melvyn Little
Recombinant human monoclonal antibodies. Basic principles of the immune system transferred to E. coli.
Cell biophysics 1992;21(1-3):81-91.
1992: Stefan Dübel; Frank Breitling; I Klewinghaus; Melvyn Little
Regulated secretion and purification of recombinant antibodies in E. coli.
Cell biophysics 1992;21(1-3):69-79.
1992: T Seehaus; Frank Breitling; Stefan Dübel; I Klewinghaus; Melvyn Little
A vector for the removal of deletion mutants from antibody libraries.
Gene 1992;114(2):235-7.
1991: P Fuchs; Frank Breitling; Stefan Dübel; T Seehaus; Melvyn Little
Targeting recombinant antibodies to the surface of Escherichia coli: fusion to a peptidoglycan associated lipoprotein.
Bio/technology (Nature Publishing Company) 1991;9(12):1369-72.
1991: Frank Breitling; Stefan Dübel; T Seehaus; I Klewinghaus; Melvyn Little
A surface expression vector for antibody screening.
Gene 1991;104(2):147-53.
1988: Melvyn Little; T Seehaus
Comparative analysis of tubulin sequences.
Comparative biochemistry and physiology. B, Comparative biochemistry 1988;90(4):655-70.