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Melissa Little

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TOP 3
Yu Leng Phua; Melissa H Little; Nick Martel; David J Pennisi; Lorine Wilkinson
Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.
Christina V Jones; Melissa H Little; Hayley Dickinson; Graham Jenkin; Bree A Rumballe; Samy Sakkal; Kenneth A Walker; Timothy M Williams; Sharon D Ricardo
M2 macrophage polarisation is associated with alveolar formation during postnatal lung development.
Han Sheng Chiu; Melissa H Little; Lorine Wilkinson; J Philippe York; Pumin Zhang; David J Pennisi
Production of a mouse line with a conditional Crim1 mutant allele.

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All Publications

2013: Yu Leng Phua; Melissa H Little; Nick Martel; David J Pennisi; Lorine Wilkinson
Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.
The Journal of pathology 2013;229(5):685-96.
2013: Christina V Jones; Melissa H Little; Hayley Dickinson; Graham Jenkin; Bree A Rumballe; Samy Sakkal; Kenneth A Walker; Timothy M Williams; Sharon D Ricardo
M2 macrophage polarisation is associated with alveolar formation during postnatal lung development.
Respiratory research 2013;14():41.
2012: Han Sheng Chiu; Melissa H Little; Lorine Wilkinson; J Philippe York; Pumin Zhang; David J Pennisi
Production of a mouse line with a conditional Crim1 mutant allele.
Genesis (New York, N.Y. : 2000) 2012;50(9):711-6.
2012: Lorine Wilkinson; Michael J Nguyen; Yu Leng Phua; Graham J Galloway; Hikaru Hashitani; Nyoman D Kurniawan; Richard J Lang; Joan Li; Melissa H Little
Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice.
The Journal of pathology 2012;227(4):499-510.
2012: Melissa H Little; Andrew P McMahon
Mammalian kidney development: principles, progress, and projections.
Cold Spring Harbor perspectives in biology 2012;4(5):.
2012: Jing Yu; Timothy Lawrence Bailey; Mary Duah; Diane Faria; Kylie Georgas; Paul A Gray; Sean M Grimmond; Jin-Jin Guo; Jennifer K Hansard; Jan P Junker; A Michaela Krautzberger; Melissa H Little; Qiufu Ma; Philip Machanick; Jill McMahon; Qun Ren; David H Rowitch; Bree Rumballe; Karl Staser; Charles D Stiles; Rathi D Thiagarajan; Michael T Valerius; Alexander van Oudenaarden; Joe Vaughan; Andrew P McMahon
Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.
Development (Cambridge, England) 2012;139(10):1863-73.
2012: David J Pennisi; D G Simmons; Lorine Wilkinson; H S Chiu; G Kinna; Melissa H Little
Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta.
Placenta 2012;33(3):175-82.
2012: Fiona Rae; Nadia Rosenthal; Esfir Slonimsky; Norseha Suhaimi; Joan Li; Tommaso Nastasi; Melissa H Little
Proximal tubule overexpression of a locally acting IGF isoform, Igf-1Ea, increases inflammation after ischemic injury.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2012;22(1):6-16.
2012: Carrie B Wiese; Jing Yu; M Todd Valerius; Jane Armstrong; Jane Brennan; Han Sheng Chiu; Nicole L Fleming; Kylie Georgas; Sara Ireland; Melissa H Little; Andrew P McMahon; E Michelle Southard-Smith
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Frontiers in neuroscience 2012;6():130.
2012: Huijun Chen; Hansheng Chiu; Marcel E Dinger; Sean M Grimmond; Peter Koopman; Emmanuelle Lesieur; Melissa H Little; James S Palmer; Alexandra Schulz; Cassy Spiller; Rathi D Thiagarajan; Dagmar Wilhelm
Identification of novel markers of mouse fetal ovary development.
PloS one 2012;7(7):e41683.
2012: Bree Rumballe; Han Sheng Chiu; Kylie Georgas; Melissa H Little
Use of in situ hybridization to examine gene expression in the embryonic, neonatal, and adult urogenital system.
Methods in molecular biology (Clifton, N.J.) 2012;886():223-39.
2012: Jamie Andrew Davies; Bernard Haggarty; Simon Harding; Derek Houghton; Melissa H Little; Sue Lloyd-MacGilp; Xinjun Piu; Yogmatee Roochun; Chris Armit; Jane Armstrong; Bruce Aronow; Jane Brennan; Duncan Davidson; Richard Baldock
Access and use of the GUDMAP database of genitourinary development.
Methods in molecular biology (Clifton, N.J.) 2012;886():185-201.
2012: Jamie Andrew Davies; Jessica Ineson; Michael Lusis; Mathieu Unbekandt; Melissa H Little
Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis.
Methods in molecular biology (Clifton, N.J.) 2012;886():135-46.
2012: Rebecca A Pelekanos; Alison M Rice; Janelle Scown; Norseha Suhaimi; Geoffrey W Osborne; Kerry Atkinson; Gary Brooke; Vashe Chandrakanthan; Melinda E Christensen; Tram Doan; Milena Gongora; Sean M Grimmond; Richard P Harvey; Joan Li; Melissa H Little
Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities.
Stem cell research 2012;8(1):58-73.
2011: Jessica Vanslambrouck; Joan Li; Melissa H Little
The renal papilla: an enigma in damage and repair.
Journal of the American Society of Nephrology : JASN 2011;22(12):2145-7.
2011: Bree Rumballe; Alexander N Combes; Kylie Georgas; Thierry Gilbert; Adler L Ju; Melissa H Little
Nephron formation adopts a novel spatial topology at cessation of nephrogenesis.
Developmental biology 2011;360(1):110-22.
2011: Maliha A Alikhan; Anthony Beckhouse; James A Deane; Anne L Fletcher; David A Hume; Christina V Jones; Michelle M Kett; Melissa H Little; Robert G Ramsay; Samy Sakkal; Chrishan S Samuel; Christine A Wells; Timothy M Williams; Sharon D Ricardo
Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses.
The American journal of pathology 2011;179(3):1243-56.
2011: Caroline Hendry; Karen Moritz; Bree Rumballe; Melissa H Little
Defining and redefining the nephron progenitor population.
Pediatric nephrology (Berlin, Germany) 2011;26(9):1395-406.
2011: Simon D Harding; Derek Houghton; Melissa H Little; Sue Lloyd-MacGilp; Andrew P McMahon; Cathy Mendelsohn; Xingjun Pi; steven potter; Yogmatee Roochun; Mehran Sharghi; E Michelle Southard-Smith; Christopher Tindal; Chris Armit; Jane Armstrong; Bruce J Aronow; Richard Baldock; Jane Brennan; Eric W Brunskill; Ying Cheng; Jamie Andrew Davies; Kylie Georgas; Brian Gottesman; Bernard Haggarty; Duncan Davidson
The GUDMAP database--an online resource for genitourinary research.
Development (Cambridge, England) 2011;138(13):2845-53.
2011: Kylie Georgas; H S Chiu; E Lesieur; Bree Rumballe; Melissa H Little
Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(6):1600-12.
2011: Eric W Brunskill; Kylie Georgas; Melissa H Little; Bree Rumballe; steven potter
Defining the molecular character of the developing and adult kidney podocyte.
PloS one 2011;6(9):e24640.
2011: Rathi D Thiagarajan; Shivangi Wani; Han S Chiu; Nicole Cloonan; brooke gardiner; Kylie Georgas; Gabriel Kolle; Keerthana Krishnan; Melissa H Little; John S Mattick; Tim R Mercer; Ehsan Nourbakhsh; Bree Rumballe; Jason A Steen; Dave Tang; Sean M Grimmond
Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling.
BMC genomics 2011;12():441.
2011: Rathi D Thiagarajan; Kylie Georgas; Bree Rumballe; Emmanuelle Lesieur; Han Sheng Chiu; Darrin Taylor; Dave Tang; Sean M Grimmond; Melissa H Little
Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
PloS one 2011;6(2):e17286.
2010: S Adelia Lin; Gabriel Kolle; Sean M Grimmond; Qi Zhou; Elizabeth Doust; Melissa H Little; Bruce Aronow; Sharon D Ricardo; Martin F Pera; John F Bertram; Andrew L Laslett
Subfractionation of differentiating human embryonic stem cell populations allows the isolation of a mesodermal population enriched for intermediate mesoderm and putative renal progenitors.
Stem cells and development 2010;19(10):1637-48.
2010: Han Sheng Chiu; John C Szucsik; Kylie Georgas; Julia L Jones; Bree Rumballe; Dave Tang; Sean M Grimmond; Alfor G Lewis; Bruce Aronow; James L Lessard; Melissa H Little
Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation.
Developmental biology 2010;344(2):1071-87.
2010: M Lusis; J Li; J Ineson; M E Christensen; A Rice; Melissa H Little
Isolation of clonogenic, long-term self renewing embryonic renal stem cells.
Stem cell research 2010;5(1):23-39.
2010: Timothy M Williams; Melissa H Little; Sharon D Ricardo
Macrophages in renal development, injury, and repair.
Seminars in nephrology 2010;30(3):255-67.
2010: Sunder Sims-Lucas; Richard J Young; Gemma Martinez; Darrin Taylor; Sean M Grimmond; Rohan Teasdale; Melissa H Little; John F Bertram; Georgina Caruana
Redirection of renal mesenchyme to stromal and chondrocytic fates in the presence of TGF-beta2.
Differentiation; research in biological diversity 2010;79(4-5):272-84.
2009: Lorine Wilkinson; Thierry Gilbert; Arnold Sipos; Ildiko Toma; David J Pennisi; Janos Peti-Peterdi; Melissa H Little
Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice.
Kidney international 2009;76(11):1161-71.
2009: Melissa H Little; John F Bertram
Is there such a thing as a renal stem cell?
Journal of the American Society of Nephrology : JASN 2009;20(10):2112-7.
2009: Melissa H Little; Fiona K Rae
Review article: Potential cellular therapies for renal disease: can we translate results from animal studies to the human condition?
Nephrology (Carlton, Vic.) 2009;14(6):544-53.
2009: Kylie Georgas; Bree Rumballe; Michael T Valerius; Han Sheng Chiu; Rathi D Thiagarajan; Emmanuelle Lesieur; Bruce Aronow; Eric W Brunskill; Alexander N Combes; Dave Tang; Darrin Taylor; Sean M Grimmond; steven potter; Andrew P McMahon; Melissa H Little
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Developmental biology 2009;332(2):273-86.
2009: Alexander N Combes; Emmanuelle Lesieur; Vincent R Harley; Andrew H Sinclair; Melissa H Little; Dagmar Wilhelm; Peter Koopman
Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(5):1033-41.
2008: Kylie Georgas; Bree Rumballe; Lorine Wilkinson; Han Sheng Chiu; Emmanuelle Lesieur; Thierry Gilbert; Melissa H Little
Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney.
Histochemistry and cell biology 2008;130(5):927-42.
2008: Melissa H Little
Tracing the life of the kidney tubule- re-establishing dogma and redirecting the options.
Cell stem cell 2008;2(3):191-2.
2008: Bree Rumballe; Kylie Georgas; Melissa H Little
High-throughput paraffin section in situ hybridization and dual immunohistochemistry on mouse tissues.
CSH protocols 2008;2008():pdb.prot5030.
2007: Fiona Rae; Kyra Woods; Tedjo Sasmono; Naomi Campanale; Darrin Taylor; Dmitry A Ovchinnikov; Sean M Grimmond; David A Hume; Sharon D Ricardo; Melissa H Little
Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
Developmental biology 2007;308(1):232-46.
2007: Lorine Wilkinson; Thierry Gilbert; Genevieve Kinna; Leah-Anne Ruta; David J Pennisi; Michelle M Kett; Melissa H Little
Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.
Journal of the American Society of Nephrology : JASN 2007;18(6):1697-708.
2007: Melissa H Little; Jane Brennan; Kylie Georgas; Jamie Andrew Davies; Duncan R Davidson; Richard Baldock; Annemiek Beverdam; John F Bertram; Blanche Capel; Han Sheng Chiu; Dave Clements; Luise A Cullen-McEwen; Jean Fleming; Thierry Gilbert; Doris Herzlinger; Derek Houghton; Matt H Kaufman; Elena Kleymenova; Peter Koopman; Alfor G Lewis; Andrew P McMahon; Cathy L Mendelsohn; Eleanor K L Mitchell; Bree Rumballe; Derina E Sweeney; Michael T Valerius; Gen Yamada; Yiya Yang; Jing Yu
A high-resolution anatomical ontology of the developing murine genitourinary tract.
Gene expression patterns : GEP 2007;7(6):680-99.
2007: David J Pennisi; Lorine Wilkinson; Gabriel Kolle; Michael L Sohaskey; Kevin Gillinder; Michael Piper; John W McAvoy; Frank J Lovicu; Melissa H Little
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(2):502-11.
2006: Georgina Caruana; Luise A Cullen-McEwen; Amy L Nelson; Xenia Kostoulias; Kyra Woods; brooke gardiner; Melissa J Davis; Darrin F Taylor; Rohan Teasdale; Sean M Grimmond; Melissa H Little; John F Bertram
Spatial gene expression in the T-stage mouse metanephros.
Gene expression patterns : GEP 2006;6(8):807-25.
2006: Melissa H Little
Regrow or repair: potential regenerative therapies for the kidney.
Journal of the American Society of Nephrology : JASN 2006;17(9):2390-401.
2006: Grant A Challen; Ivan Bertoncello; James A Deane; Sharon D Ricardo; Melissa H Little
Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity.
Journal of the American Society of Nephrology : JASN 2006;17(7):1896-912.
2006: Gemma Martinez; Kylie Georgas; Grant A Challen; Bree Rumballe; Melissa J Davis; Darrin Taylor; Rohan Teasdale; Sean M Grimmond; Melissa H Little
Definition and spatial annotation of the dynamic secretome during early kidney development.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(6):1709-19.
2006: Eleanor K L Mitchell; Darrin F Taylor; Kyra Woods; Melissa J Davis; Amy L Nelson; Rohan Teasdale; Sean M Grimmond; Melissa H Little; John F Bertram; Georgina Caruana
Differential gene expression in the developing mouse ureter.
Gene expression patterns : GEP 2006;6(5):519-38.
2006: Genevieve Kinna; Gabriel Kolle; Adrian Carter; Brian Key; Graham J Lieschke; Andrew Perkins; Melissa H Little
Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development.
Mechanisms of development 2006;123(4):277-87.
2006: Grant A Challen; Melissa H Little
A side order of stem cells: the SP phenotype.
Stem cells (Dayton, Ohio) 2006;24(1):3-12.
2005: Xiaobo Gao; Xing Chen; Mary E Taglienti; Bree Rumballe; Melissa H Little; Jordan A Kreidberg
Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa.
Development (Cambridge, England) 2005;132(24):5437-49.
2005: Anita L Cochrane; Michelle M Kett; Chrishan S Samuel; Naomi V Campanale; Warwick P Anderson; David A Hume; Melissa H Little; John F Bertram; Sharon D Ricardo
Renal structural and functional repair in a mouse model of reversal of ureteral obstruction.
Journal of the American Society of Nephrology : JASN 2005;16(12):3623-30.
2005: Shannon R Armstrong; Gordon R Campbell; Julie H Campbell; Melissa H Little
Establishment of metanephros transplantation in mice highlights contributions by both nephrectomy and pregnancy to developmental progression.
Nephron. Experimental nephrology 2005;101(4):e155-64.
2004: Grant A Challen; Gemma Martinez; Melissa J Davis; Darrin F Taylor; Mark Crowe; Rohan Teasdale; Sean M Grimmond; Melissa H Little
Identifying the molecular phenotype of renal progenitor cells.
Journal of the American Society of Nephrology : JASN 2004;15(9):2344-57.
2004: Fiona Rae; Gemma Martinez; Kevin Robert Gillinder; Aaron Smith; Gary Shooter; Alistair Forrest; Sean M Grimmond; Melissa H Little
Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1.
Oncogene 2004;23(17):3067-79.
2002: Emma Smith; Murray Hargrave; Toshiya Yamada; C Glenn Begley; Melissa H Little
Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;224(2):231-7.
2002: Edmund U-H Sim; Aaron Smith; Elida Szilagi; Fiona Rae; Panos Ioannou; Megan H Lindsay; Melissa H Little
Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.
Oncogene 2002;21(19):2948-60.
2001: Melissa H Little; Lorine Wilkinson; D L Brown; Michael Piper; T Yamada; Jennifer L Stow
Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein.
American journal of physiology. Cell physiology 2001;281(2):C486-95.
2000: Kylie Georgas; Josephine Bowles; Toshiya Yamada; Peter Koopman; Melissa H Little
Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;219(4):582-7.
2000: Frank J Lovicu; Gabriel Kolle; Toshiya Yamada; Melissa H Little; John W McAvoy
Expression of Crim1 during murine ocular development.
Mechanisms of development 2000;94(1-2):261-5.
2000: Gabriel Kolle; Kylie Georgas; GP Holmes; Melissa H Little; Toshiya Yamada
CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.
Mechanisms of development 2000;90(2):181-93.
1999: Kylie Georgas; Letitia Burridge; K Smith; GP Holmes; Georgia Chenevix-Trench; P A Ioannou; Melissa H Little
Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2.
Cytogenetics and cell genetics 1999;86(3-4):246-7.
1998: GP Holmes; K Negus; Letitia Burridge; S Raman; E Algar; Toshiya Yamada; Melissa H Little
Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.
Mechanisms of development 1998;79(1-2):57-72.
1996: Melissa H Little; G Holmes; L Pell; A Caricasole; A Duarte; M Law; Andrew Ward; Brandon J Wainwright
A novel target for the Wilms' tumour suppressor protein (WT1) is bound by a unique combination of zinc fingers.
Oncogene 1996;13(7):1461-9.
1996: K Negus; G H Holmes; Carol Wicking; Brandon J Wainwright; Melissa H Little
+P5 (D1S3309E), a novel target binding site for the Wilms' tumour suppressor 1 (WT1) gene, maps to human chromosome 1q21-->22.
Cytogenetics and cell genetics 1996;72(4):306-9.
1993: James A Byrne; Lisa A Simms; Melissa H Little; E M Algar; P J Smith
Three non-overlapping regions of chromosome arm 11p allele loss identified in infantile tumors of adrenal and liver.
Genes, chromosomes & cancer 1993;8(2):104-11.
1993: Melissa H Little; K A Williamson; marcel mannens; A Kelsey; C Gosden; Nicholas D Hastie; Veronica van Heyningen
Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.
Human molecular genetics 1993;2(3):259-64.
1992: Wendy A Bickmore; K Oghene; Melissa H Little; Anne Seawright; Veronica van Heyningen; Nicholas D Hastie
Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript.
Science (New York, N.Y.) 1992;257(5067):235-7.
1992: Melissa H Little; J Prosser; A Condie; P J Smith; Veronica van Heyningen; Nicholas D Hastie
Zinc finger point mutations within the WT1 gene in Wilms tumor patients.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4791-5.
1992: James A Byrne; Melissa H Little; P J Smith
The M1 subunit of ribonucleotide reductase refines mapping of genetic rearrangements at chromosome 11p15.
Cancer genetics and cytogenetics 1992;59(2):206-9.
1992: Melissa H Little; R Dunn; James A Byrne; Anne Seawright; P J Smith; K Pritchard-Jones; Veronica van Heyningen; Nicholas D Hastie
Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.
Oncogene 1992;7(4):635-41.
1992: Melissa H Little; J Clarke; J Byrne; R Dunn; P J Smith
Allelic loss on chromosome 11p is a less frequent event in bilateral than in unilateral Wilms' tumours.
European journal of cancer (Oxford, England : 1990) 1992;28A(11):1876-80.