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Mark Little

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Gerry M Kendall; Mark P Little; J R Meara; J C H Miles; Tim Vincent; R Wakeford; KJ Bunch; M F G Murphy
A record-based case-control study of natural background radiation and the incidence of childhood leukaemia and other cancers in Great Britain during 1980-2006.
Swatee P Patel; Juha Pekkanen; Anneli Pouta; Alina Rodriguez; Dexter Canoy; Paul Elliott; Terttu Harju; Anna-Liisa Hartikainen; Jaana Laitinen; Mark P Little; Marjo-Riitta Järvelin
Associations between pre-pregnancy obesity and asthma symptoms in adolescents.
Martin Walker; Boakye A Boatin; Mark P Little; Edoh W Soumbey-Alley; Karen S Wagner; María-Gloria Basáñez
Density-dependent mortality of the human host in onchocerciasis: relationships between microfilarial load and excess mortality.

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All Publications

2013: Gerry M Kendall; Mark P Little; J R Meara; J C H Miles; Tim Vincent; R Wakeford; KJ Bunch; M F G Murphy
A record-based case-control study of natural background radiation and the incidence of childhood leukaemia and other cancers in Great Britain during 1980-2006.
Leukemia 2013;27(1):3-9.
2012: Swatee P Patel; Juha Pekkanen; Anneli Pouta; Alina Rodriguez; Dexter Canoy; Paul Elliott; Terttu Harju; Anna-Liisa Hartikainen; Jaana Laitinen; Mark P Little; Marjo-Riitta Järvelin
Associations between pre-pregnancy obesity and asthma symptoms in adolescents.
Journal of epidemiology and community health 2012;66(9):809-14.
2012: Martin Walker; Boakye A Boatin; Mark P Little; Edoh W Soumbey-Alley; Karen S Wagner; María-Gloria Basáñez
Density-dependent mortality of the human host in onchocerciasis: relationships between microfilarial load and excess mortality.
PLoS neglected tropical diseases 2012;6(3):e1578.
2011: Gerald Kendall; Mark P Little; Richard Wakeford
Numbers and proportions of leukemias in young people and adults induced by radiation of natural origin.
Leukemia research 2011;35(8):1039-43.
2010: Aliki J Taylor; Mark P Little; David L Winter; Elaine Sugden; David W Ellison; Charles A Stiller; Marilyn Stovall; Clare Frobisher; Emma R Lancashire; Raoul C Reulen; Mike M Hawkins
Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(36):5287-93.
2010: Mark P Little; Richard Wakeford; J H Lubin; G M Kendall
The statistical power of epidemiological studies analyzing the relationship between exposure to ionizing radiation and cancer, with special reference to childhood leukemia and natural background radiation.
Radiation research 2010;174(3):387-402.
2010: Mark P Little
Do non-targeted effects increase or decrease low dose risk in relation to the linear-non-threshold (LNT) model?
Mutation research 2010;687(1-2):17-27.
2010: Mark P Little; E Janet Tawn; Ioanna Tzoulaki; Richard Wakeford; G Hildebrandt; F Paris; S Tapio; Paul Elliott
Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms.
Radiation and environmental biophysics 2010;49(2):139-53.
2010: Mark P Little
Cancer models, genomic instability and somatic cellular Darwinian evolution.
Biology direct 2010;5():19; discussion 19.
2010: Mark P Little; Wolfgang F Heidenreich; Guangquan Li
Parameter identifiability and redundancy: theoretical considerations.
PloS one 2010;5(1):e8915.
2009: Mark P Little; Richard Wakeford; Gerald M Kendall
Updated estimates of the proportion of childhood leukaemia incidence in Great Britain that may be caused by natural background ionising radiation.
Journal of radiological protection : official journal of the Society for Radiological Protection 2009;29(4):467-82.
2009: Richard Wakeford; Gerald M Kendall; Mark P Little
The risk of cancer from natural background ionizing radiation.
Health physics 2009;97(6):637-8; author reply 638.
2009: Mark P Little; Anna Gola; Ioanna Tzoulaki
A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure.
PLoS computational biology 2009;5(10):e1000539.
2009: Mark P Little
Heterogeneity of variation of relative risk by age at exposure in the Japanese atomic bomb survivors.
Radiation and environmental biophysics 2009;48(3):253-62.
2009: Mark P Little
Cancer and non-cancer effects in Japanese atomic bomb survivors.
Journal of radiological protection : official journal of the Society for Radiological Protection 2009;29(2A):A43-59.
2009: Mark P Little; Richard Wakeford; E Janet Tawn; Simon D Bouffler; Amy Berrington de Gonzalez
Risks associated with low doses and low dose rates of ionizing radiation: why linearity may be (almost) the best we can do.
Radiology 2009;251(1):6-12.
2009: Mark P Little; Wolfgang F Heidenreich; Guangquan Li
Parameter identifiability and redundancy in a general class of stochastic carcinogenesis models.
PloS one 2009;4(12):e8520.
2009: Ioanna Tzoulaki; Mariam Molokhia; Vasa Curcin; Mark P Little; Christopher J Millett; Anthea Ng; Robert I Hughes; Kamlesh Khunti; Martin R Wilkins; Azeem Majeed; Paul Elliott
Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.
BMJ (Clinical research ed.) 2009;339():b4731.
2008: Mark P Little; Paolo Vineis; Guangquan Li
A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data.
Journal of theoretical biology 2008;254(2):229-38.
2008: Mark P Little; Richard Wakeford
Systematic review of epidemiological studies of exposure to tritium.
Journal of radiological protection : official journal of the Society for Radiological Protection 2008;28(1):9-32.
2008: Mark P Little; Wolfgang F Heidenreich; Suresh H Moolgavkar; H Schöllnberger; D C Thomas
Systems biological and mechanistic modelling of radiation-induced cancer.
Radiation and environmental biophysics 2008;47(1):39-47.
2008: Mark P Little; B E Lambert
Systematic review of experimental studies on the relative biological effectiveness of tritium.
Radiation and environmental biophysics 2008;47(1):71-93.
2008: Mark P Little
Leukaemia following childhood radiation exposure in the Japanese atomic bomb survivors and in medically exposed groups.
Radiation protection dosimetry 2008;132(2):156-65.
2008: Mark P Little; EJ Tawn; I Tzoulaki; Richard Wakeford; Guido Hildebrandt; F Paris; S Tapio; P Elliott
A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms.
Radiation research 2008;169(1):99-109.
2007: Mark P Little; Per Hall; Monty W Charles
Are cancer risks associated with exposures to ionising radiation from internal emitters greater than those in the Japanese A-bomb survivors?
Radiation and environmental biophysics 2007;46(4):299-310.
2007: Paul Elliott; Lesley L Walker; Mark P Little; John Blair-West; Robert E Shade; D Rick Lee; Pierre Rouquet; Eric M Leroy; Xavier Jeunemaitre; Raymond Ardaillou; Francoise Paillard; Pierre Meneton; Derek A Denton
Change in salt intake affects blood pressure of chimpanzees: implications for human populations.
Circulation 2007;116(14):1563-8.
2007: Mark P Little
A multi-compartment cell repopulation model allowing for inter-compartmental migration following radiation exposure, applied to leukaemia.
Journal of theoretical biology 2007;245(1):83-97.
2007: Mark P Little; M-R Järvelin; D E Neasham; T Lissauer; Philip J Steer
Factors associated with fall in neonatal intubation rates in the United Kingdom--prospective study.
BJOG : an international journal of obstetrics and gynaecology 2007;114(2):156-64.
2007: Mark P Little; Guangquan Li
Stochastic modelling of colon cancer: is there a role for genomic instability?
Carcinogenesis 2007;28(2):479-87.
2006: María-Gloria Basáñez; S D S Pion; Thomas S Churcher; Lutz Breitling; Mark P Little; Michel Boussinesq
River blindness: a success story under threat?
PLoS medicine 2006;3(9):e371.
2005: João A N Filipe; Michel Boussinesq; Alfons Renz; Richard C Collins; Sarai Vivas-Martinez; Maria E Grillet; Mark P Little; María-Gloria Basáñez
Human infection patterns and heterogeneous exposure in river blindness.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15265-70.
2005: Mark P Little; Pauline Brocard; Paul Elliott; Philip J Steer
Hemoglobin concentration in pregnancy and perinatal mortality: a London-based cohort study.
American journal of obstetrics and gynecology 2005;193(1):220-6.
2005: Mark P Little; João A N Filipe; Kevin Prise; Melvyn Folkard; Oleg V Belyakov
A model for radiation-induced bystander effects, with allowance for spatial position and the effects of cell turnover.
Journal of theoretical biology 2005;232(3):329-38.
2004: Philip J Steer; Mark P Little; Tina Kold-Jensen; Jean Chapple; Paul Elliott
Maternal blood pressure in pregnancy, birth weight, and perinatal mortality in first births: prospective study.
BMJ (Clinical research ed.) 2004;329(7478):1312.
2004: James Bennett; Mark P Little; Sylvia Richardson
Flexible dose-response models for Japanese atomic bomb survivor data: Bayesian estimation and prediction of cancer risk.
Radiation and environmental biophysics 2004;43(4):233-45.
2004: Mark P Little
The bystander effect model of Brenner and Sachs fitted to lung cancer data in 11 cohorts of underground miners, and equivalence of fit of a linear relative risk model with adjustment for attained age and age at exposure.
Journal of radiological protection : official journal of the Society for Radiological Protection 2004;24(3):243-55.
2004: Mark P Little; Maria Blettner; John D Boice; Bryn A Bridges; Elisabeth Cardis; Monty W Charles; Florent de Vathaire; Richard Doll; Kenzo Fujimoto; Dudley T Goodhead; Bernd Grosche; Per Hall; Wolfgang F Heidenreich; Peter Jacob; Suresh H Moolgavkar; Colin R Muirhead; Ohtsura Niwa; Herwig G Paretzke; Richard Richardson; Jonathan M Samet; Yasuhito Sasaki; Roy E Shore; Tore Straume; Richard Wakeford
Funding crisis at the Radiation Effects Research Foundation.
Journal of radiological protection : official journal of the Society for Radiological Protection 2004;24(3):195-7.
2004: Mark P Little; Maria Blettner; John D Boice; Bryn A Bridges; Elisabeth Cardis; Monty W Charles; Florent de Vathaire; Richard Doll; Kenzo Fujimoto; Dudley T Goodhead; Bernd Grosche; Per Hall; Wolfgang F Heidenreich; Peter Jacob; Suresh H Moolgavkar; Colin R Muirhead; Ohtsura Niwa; Herwig G Paretzke; Richard Richardson; Jonathan M Samet; Yasuhito Sasaki; Roy E Shore; Tore Straume; Richard Wakeford
Potential funding crisis for the Radiation Effects Research Foundation.
Lancet 2004;364(9434):557-8.
2004: Mark P Little
Threshold and other departures from linear-quadratic curvature in the non-cancer mortality dose-response curve in the Japanese atomic bomb survivors.
Radiation and environmental biophysics 2004;43(2):67-75.
2004: Mark P Little; Maria-Gloria Basanez; Lutz Breitling; Boakye A Boatin; Edoh S Alley
Incidence of blindness during the Onchocerciasis control programme in western Africa, 1971-2002.
The Journal of infectious diseases 2004;189(10):1932-41.
2004: Mark P Little; Lutz Breitling; María-Gloria Basáñez; Edoh S Alley; Boakye A Boatin
Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study.
Lancet 2004;363(9420):1514-21.
2003: Tom Sorahan; R G E Haylock; Colin R Muirhead; KJ Bunch; LJ Kinlen; Mark P Little; Gerald Draper; Gerry M Kendall; Robert J Lancashire; MA English
Cancer in the offspring of radiation workers: an investigation of employment timing and a reanalysis using updated dose information.
British journal of cancer 2003;89(7):1215-20.
2003: Richard Wakeford; Mark P Little
Risk coefficients for childhood cancer after intrauterine irradiation: a review.
International journal of radiation biology 2003;79(5):293-309.
2003: Mark P Little
Risks associated with ionizing radiation.
British medical bulletin 2003;68():259-75.
2003: Mark P Little; EJ Tawn
Comments on 'Estimation of X ray overexposure in a childhood leukaemia cluster by means of chromosome aberration analysis'.
Radiation protection dosimetry 2003;103(1):77-9; author reply 79-81.
2002: María-Gloria Basáñez; Richard C Collins; Charles H Porter; Mark P Little; David Brandling-Bennett
Transmission intensity and the patterns of Onchocerca volvulus infection in human communities.
The American journal of tropical medicine and hygiene 2002;67(6):669-79.
2002: Mark P Little
Absence of evidence for differences in the dose-response for cancer and non-cancer endpoints by acute injury status in the Japanese atomic-bomb survivors.
International journal of radiation biology 2002;78(11):1001-10.
2002: Richard Wakeford; Mark P Little
Childhood cancer after low-level intrauterine exposure to radiation.
Journal of radiological protection : official journal of the Society for Radiological Protection 2002;22(3A):A123-7.
2002: Mark P Little; Richard Wakeford
The bystander effect in experimental systems and compatibility with radon-induced lung cancer in humans.
Journal of radiological protection : official journal of the Society for Radiological Protection 2002;22(3A):A27-31.
2002: Mark P Little
The proportion of thyroid cancers in the Japanese atomic bomb survivors associated with natural background radiation.
Journal of radiological protection : official journal of the Society for Radiological Protection 2002;22(3):279-91.
2002: Mark P Little
Comparisons of lung tumour mortality risk in the Japanese A-bomb survivors and in the Colorado Plateau uranium miners: support for the ICRP lung model.
International journal of radiation biology 2002;78(3):145-63.
2002: Mark P Little; R G E Haylock; Colin R Muirhead
Modelling lung tumour risk in radon-exposed uranium miners using generalizations of the two-mutation model of Moolgavkar, Venzon and Knudson.
International journal of radiation biology 2002;78(1):49-68.
2001: Mark P Little; Richard Wakeford
The bystander effect in C3H 10T cells and radon-induced lung cancer.
Radiation research 2001;156(6):695-9.
2001: Mark P Little
Comparison of the risks of cancer incidence and mortality following radiation therapy for benign and malignant disease with the cancer risks observed in the Japanese A-bomb survivors.
International journal of radiation biology 2001;77(4):431-64.
2000: Wolfgang F Heidenreich; M J P Brugmans; Mark P Little; Henk P Leenhouts; Herwig G Paretzke; M Morin; J Lafuma
Analysis of lung tumour risk in radon-exposed rats: an intercomparison of multi-step modelling.
Radiation and environmental biophysics 2000;39(4):253-64.
2000: Mark P Little; I Deltour; Sylvia Richardson
Projection of cancer risks from the Japanese atomic bomb survivors to the England and Wales population taking into account uncertainty in risk parameters.
Radiation and environmental biophysics 2000;39(4):241-52.
2000: Mark P Little
A comparison of the degree of curvature in the cancer incidence dose-response in Japanese atomic bomb survivors with that in chromosome aberrations measured in vitro.
International journal of radiation biology 2000;76(10):1365-75.
2000: Mark P Little; Colin R Muirhead
Derivation of low-dose extrapolation factors from analysis of curvature in the cancer incidence dose response in Japanese atomic bomb survivors.
International journal of radiation biology 2000;76(7):939-53.
1999: Mark P Little; Colin R Muirhead; R G E Haylock; J M Thomas
Relative risks of radiation-associated cancer: comparison of second cancer in therapeutically irradiated populations with the Japanese atomic bomb survivors.
Radiation and environmental biophysics 1999;38(4):267-83.
1999: Mark P Little
A comparison of the risk of stillbirth associated with paternal pre-conception irradiation in the Sellafield workforce with that of stillbirth and untoward pregnancy outcome among Japanese atomic bomb survivors.
Journal of radiological protection : official journal of the Society for Radiological Protection 1999;19(4):361-73.
1999: Mark P Little; H A Weiss; J D Boice; Sarah C Darby; Nicholas E Day; Colin R Muirhead
Risks of leukemia in Japanese atomic bomb survivors, in women treated for cervical cancer, and in patients treated for ankylosing spondylitis.
Radiation research 1999;152(3):280-92.
1999: Mark P Little; Monty W Charles
Tumor induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239.
British journal of cancer 1999;80(3-4):627-8.
1999: Colin R Muirhead; A A Goodill; R G E Haylock; J Vokes; Mark P Little; D A Jackson; JA O'Hagan; J M Thomas; Gerry M Kendall; T J Silk; D Bingham; G L C Berridge
Occupational radiation exposure and mortality: second analysis of the National Registry for Radiation Workers.
Journal of radiological protection : official journal of the Society for Radiological Protection 1999;19(1):3-26.
1999: Mark P Little; J D Boice
Comparison of breast cancer incidence in the Massachusetts tuberculosis fluoroscopy cohort and in the Japanese atomic bomb survivors.
Radiation research 1999;151(2):218-24.
1999: Mark P Little; Colin R Muirhead; Monty W Charles
Describing time and age variations in the risk of radiation-induced solid tumour incidence in the Japanese atomic bomb survivors using generalized relative and absolute risk models.
Statistics in medicine 1999;18(1):17-33.
1998: Mark P Little; Florent de Vathaire; Akthar Shamsaldin; Odile Oberlin; Sarah Campbell; Emmanuel Grimaud; Jean Chavaudra; R G E Haylock; Colin R Muirhead
Risks of brain tumour following treatment for cancer in childhood: modification by genetic factors, radiotherapy and chemotherapy.
International journal of cancer. Journal international du cancer 1998;78(3):269-75.
1998: Mark P Little; Colin R Muirhead
Curvature in the cancer mortality dose response in Japanese atomic bomb survivors: absence of evidence of threshold.
International journal of radiation biology 1998;74(4):471-80.
1998: Mark P Little; Florent de Vathaire; Monty W Charles; Michael M Hawkins; Colin R Muirhead
Variations with time and age in the risks of solid cancer incidence after radiation exposure in childhood.
Statistics in medicine 1998;17(12):1341-55.
1997: Mark P Little; Colin R Muirhead
Curvilinearity in the dose-response curve for cancer in Japanese atomic bomb survivors.
Environmental health perspectives 1997;105 Suppl 6():1505-9.
1997: Mark P Little
Estimates of neutron relative biological effectiveness derived from the Japanese atomic bomb survivors.
International journal of radiation biology 1997;72(6):715-26.
1997: Gerald Draper; Mark P Little; Tom Sorahan; LJ Kinlen; KJ Bunch; A J Conquest; Gerry M Kendall; G W Kneale; Robert J Lancashire; Colin R Muirhead; C M O'Connor; Tim Vincent
Cancer in the offspring of radiation workers: a record linkage study.
BMJ (Clinical research ed.) 1997;315(7117):1181-8.
1997: Mark P Little; Monty W Charles
The risk of non-melanoma skin cancer incidence in the Japanese atomic bomb survivors.
International journal of radiation biology 1997;71(5):589-602.
1996: Mark P Little; Colin R Muirhead
Evidence for curvilinearity in the cancer incidence dose-response in the Japanese atomic bomb survivors.
International journal of radiation biology 1996;70(1):83-94.
1996: Mark P Little; Colin R Muirhead; C A Stiller
Modelling lymphocytic leukaemia incidence in England and Wales using generalizations of the two-mutation model of carcinogenesis of Moolgavkar, Venzon and Knudson.
Statistics in medicine 1996;15(10):1003-22.
1995: Mark P Little
Are two mutations sufficient to cause cancer? Some generalizations of the two-mutation model of carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the multistage model of Armitage and Doll.
Biometrics 1995;51(4):1278-91.
1995: Mark P Little; Monty W Charles; R Wakeford
A review of the risks of leukemia in relation to parental pre-conception exposure to radiation.
Health physics 1995;68(3):299-310.
1994: Mark P Little; M M Hawkins; Monty W Charles; N G Hildreth
Corrections to the paper "Fitting the Armitage-Doll model to radiation-exposed cohorts and implications for population cancer risks.
Radiation research 1994;137(1):124-8.
1992: Mark P Little; M M Hawkins; Monty W Charles; N G Hildreth
Fitting the Armitage-Doll model to radiation-exposed cohorts and implications for population cancer risks.
Radiation research 1992;132(2):207-21.
1991: Mark P Little; Monty W Charles
Absence of risk associated with exposure to radiation before conception in Japan.
BMJ (Clinical research ed.) 1991;302(6789):1404.
1991: Mark P Little; M M Hawkins; Roy E Shore; Monty W Charles; N G Hildreth
Time variations in the risk of cancer following irradiation in childhood.
Radiation research 1991;126(3):304-16.
1991: Mark P Little; Monty W Charles
Selection effects in the Japanese bomb survivors.
International journal of radiation biology 1991;59(6):1483, 1485-6.
1990: Mark P Little; Monty W Charles
Bomb survivor selection and consequences for estimates of population cancer risks.
Health physics 1990;59(6):765-75.