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Troy Littleton

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Chemicals & Drugs

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Publications

TOP 3
Jan E Melom; J Troy Littleton
Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility.
Jihye Lee; Yulia Akbergenova; Zhuo Guan; J Troy Littleton
Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.
Lauren K Buhl; Sarah Huntwork-Rodriguez; Ramon A Jorquera; Yulia Akbergenova; Dina Volfson; J Troy Littleton
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.

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All Publications

2013: Jan E Melom; J Troy Littleton
Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(3):1169-78.
2013: Jihye Lee; Yulia Akbergenova; Zhuo Guan; J Troy Littleton
Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(1):187-200.
2013: Lauren K Buhl; Sarah Huntwork-Rodriguez; Ramon A Jorquera; Yulia Akbergenova; Dina Volfson; J Troy Littleton
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.
Molecular and cellular neurosciences 2013;52():161-72.
2012: Ramon A Jorquera; Yulia Akbergenova; Richard W Cho; Sarah Huntwork-Rodriguez; J Troy Littleton
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(50):18234-45.
2012: Robin J Stevens; Yulia Akbergenova; Ramon A Jorquera; J Troy Littleton
Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(50):18054-67, 18067a.
2012: Kurt R Weiss; Yoko Kimura; Wyan-Ching Mimi Lee; J Troy Littleton
Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.
Genetics 2012;190(2):581-600.
2011: Kathryn P Harris; J Troy Littleton
Vesicle trafficking: a Rab family profile.
Current biology : CB 2011;21(20):R841-3.
2011: Jan Elizabeth Melom; J Troy Littleton
Synapse development in health and disease.
Current opinion in genetics & development 2011;21(3):256-61.
2011: Robin J Stevens; J Troy Littleton
Synaptic growth: dancing with adducin.
Current biology : CB 2011;21(10):R402-5.
2011: Avital A Rodal; Aline D Blunk; Yulia Akbergenova; Ramon A Jorquera; Lauren K Buhl; J Troy Littleton
A presynaptic endosomal trafficking pathway controls synaptic growth signaling.
The Journal of cell biology 2011;193(1):201-17.
2011: Joost Schulte; Katharine J Sepp; Chaohong Wu; Pengyu Hong; J Troy Littleton
High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.
PloS one 2011;6(8):e23841.
2011: Zhuo Guan; Lauren K Buhl; William G Quinn; J Troy Littleton
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.
Learning & memory (Cold Spring Harbor, N.Y.) 2011;18(4):191-206.
2010: Richard W Cho; Yun Song; J Troy Littleton
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.
Molecular and cellular neurosciences 2010;45(4):389-97.
2010: Motojiro Yoshihara; Zhuo Guan; J Troy Littleton
Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14869-74.
2010: Chaohong Wu; Joost Schulte; Katharine J Sepp; J Troy Littleton; Pengyu Hong
Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening.
Neuroinformatics 2010;8(2):83-100.
2010: Joost Schulte; Katharine J Sepp; Ramon A Jorquera; Chaohong Wu; Yun Song; Pengyu Hong; J Troy Littleton
DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(15):5189-203.
2009: Cynthia F Barber; Ramon A Jorquera; Jan E Melom; J Troy Littleton
Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.
The Journal of cell biology 2009;187(2):295-310.
2009: Sheng Zhang; Mel B Feany; Sudipta Saraswati; J Troy Littleton; Norbert Perrimon
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.
Disease models & mechanisms 2009;2(5-6):247-66.
2008: Avital A Rodal; Rebecca N Motola-Barnes; J Troy Littleton
Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(33):8316-25.
2008: Avital A Rodal; J Troy Littleton
Synaptic endocytosis: illuminating the role of clathrin assembly.
Current biology : CB 2008;18(6):R259-61.
2007: Sarah Huntwork; J Troy Littleton
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth.
Nature neuroscience 2007;10(10):1235-7.
2007: Mark D Mattaliano; Enrico S Montana; Katherine M Parisky; J Troy Littleton; Leslie C Griffith
The Drosophila ARC homolog regulates behavioral responses to starvation.
Molecular and cellular neurosciences 2007;36(2):211-21.
2007: Sudipta Saraswati; Bill Adolfsen; J Troy Littleton
Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14122-7.
2007: Yoko Kimura; Wyan-Ching Mimi Lee; J Troy Littleton
Therapeutic prospects for the prevention of neurodegeneration in Huntington's disease and the polyglutamine repeat disorders.
Mini reviews in medicinal chemistry 2007;7(1):99-106.
2006: Geoff E Stilwell; Sudipta Saraswati; J Troy Littleton; Scott W Chouinard
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
The European journal of neuroscience 2006;24(8):2211-22.
2006: J Troy Littleton
Mixing and matching during synaptic vesicle endocytosis.
Neuron 2006;51(2):149-51.
2006: Enrico S Montana; J Troy Littleton
Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response.
The Journal of biological chemistry 2006;281(12):8100-9.
2005: Motojiro Yoshihara; Bill Adolfsen; Kathleen T Galle; J Troy Littleton
Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.
Science (New York, N.Y.) 2005;310(5749):858-63.
2005: Zhuo Guan; Sudipta Saraswati; Bill Adolfsen; J Troy Littleton
Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system.
Neuron 2005;48(1):91-107.
2004: Bill Adolfsen; Sudipta Saraswati; Motojiro Yoshihara; J Troy Littleton
Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment.
The Journal of cell biology 2004;166(2):249-60.
2004: Ping Wang; Sudipta Saraswati; Zhuo Guan; Carol J Watkins; Richard J Wurtman; J Troy Littleton
A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4518-29.
2004: Enrico S Montana; J Troy Littleton
Characterization of a hypercontraction-induced myopathy in Drosophila caused by mutations in Mhc.
The Journal of cell biology 2004;164(7):1045-54.
2004: Wyan-Ching Mimi Lee; Motojiro Yoshihara; J Troy Littleton
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3224-9.
2004: Ian P Coyle; Young-Ho Koh; Wyan-Ching Mimi Lee; Jessica Slind; Tim Fergestad; J Troy Littleton; Barry Ganetzky
Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila.
Neuron 2004;41(4):521-34.
2003: Gabrielle E Rieckhof; Motojiro Yoshihara; Zhuo Guan; J Troy Littleton
Presynaptic N-type calcium channels regulate synaptic growth.
The Journal of biological chemistry 2003;278(42):41099-108.
2003: J Troy Littleton; Morgan Sheng
Neurobiology: synapses unplugged.
Nature 2003;423(6943):931-2.
2003: Motojiro Yoshihara; Bill Adolfsen; J Troy Littleton
Is synaptotagmin the calcium sensor?
Current opinion in neurobiology 2003;13(3):315-23.
2002: Motojiro Yoshihara; J Troy Littleton
Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.
Neuron 2002;36(5):897-908.
2001: J Troy Littleton; R J Barnard; Steven A Titus; J Slind; Edwin R Chapman; Barry Ganetzky
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12233-8.
2001: M Yoshihara; A W Ensminger; J Troy Littleton
Neurobiology and the Drosophila genome.
Functional & integrative genomics 2001;1(4):235-40.
2001: Bill Adolfsen; J Troy Littleton
Genetic and molecular analysis of the synaptotagmin family.
Cellular and molecular life sciences : CMLS 2001;58(3):393-402.
2001: J Troy Littleton; J Bai; B Vyas; R Desai; A E Baltus; MB Garment; SD Carlson; Barry Ganetzky; Edwin R Chapman
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1421-33.
2000: R C Desai; B Vyas; Cynthia A Earles; J Troy Littleton; J A Kowalchyck; Thomas F J Martin; Edwin R Chapman
The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis.
The Journal of cell biology 2000;150(5):1125-36.
2000: J Troy Littleton
A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila.
The Journal of cell biology 2000;150(2):F77-82.
2000: J Troy Littleton; Barry Ganetzky
Ion channels and synaptic organization: analysis of the Drosophila genome.
Neuron 2000;26(1):35-43.
2000: G M Rubin; M D Yandell; Jennifer Wortman; G L Gabor Miklos; C R Nelson; I K Hariharan; M E Fortini; P W Li; R Apweiler; W Fleischmann; J M Cherry; S Henikoff; M P Skupski; S Misra; Michael Ashburner; E Birney; M S Boguski; Thomas Brody; P Brokstein; S E Celniker; S A Chervitz; D Coates; A Cravchik; A Gabrielian; R F Galle; W M Gelbart; R A George; L S Goldstein; F Gong; P Guan; N L Harris; B A Hay; R A Hoskins; J Li; Z Li; R O Hynes; S J Jones; P M Kuehl; B Lemaitre; J Troy Littleton; D K Morrison; C Mungall; P H O'Farrell; Oxana Pickeral; C Shue; L B Vosshall; J Zhang; Q Zhao; X H Zheng; S Lewis
Comparative genomics of the eukaryotes.
Science (New York, N.Y.) 2000;287(5461):2204-15.
1999: J Troy Littleton; T L Serano; G M Rubin; Barry Ganetzky; Edwin R Chapman
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV.
Nature 1999;400(6746):757-60.
1999: J Troy Littleton; L Pallanck; Barry Ganetzky
Mechanisms of neurotransmitter release.
International review of neurobiology 1999;43():139-61.
1998: J Troy Littleton; Edwin R Chapman; Robert Kreber; MB Garment; SD Carlson; Barry Ganetzky
Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.
Neuron 1998;21(2):401-13.
1998: Mark Wu; J Troy Littleton; Manzoor Bhat; A Prokop; Hugo J Bellen
ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner.
The EMBO journal 1998;17(1):127-39.
1997: J Troy Littleton; Manzoor Bhat; Hugo J Bellen
Deciphering the function of neurexins at cellular junctions.
The Journal of cell biology 1997;137(4):793-6.
1996: Stefan Baumgartner; J Troy Littleton; Kendal Broadie; Manzoor Bhat; R Harbecke; Judith A Lengyel; Ruth Chiquet-Ehrismann; A Prokop; Hugo J Bellen
A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function.
Cell 1996;87(6):1059-68.
1995: J Troy Littleton; L Upton; A Kania
Immunocytochemical analysis of axonal outgrowth in synaptotagmin mutations.
Journal of neurochemistry 1995;65(1):32-40.
1995: J Troy Littleton; Hugo J Bellen
Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent manner.
Trends in neurosciences 1995;18(4):177-83.
1995: J Troy Littleton; Hugo J Bellen
Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis.
Invertebrate neuroscience : IN 1995;1(1):3-13.
1994: J Troy Littleton; M Stern; M Perin; Hugo J Bellen
Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10888-92.
1994: K L Schulze; J Troy Littleton; A Salzberg; N Halachmi; M Stern; Z Lev; Hugo J Bellen
rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo.
Neuron 1994;13(5):1099-108.
1994: Kendal Broadie; Hugo J Bellen; Aaron DiAntonio; J Troy Littleton; Thomas L Schwarz
Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10727-31.
1994: J Troy Littleton; Hugo J Bellen
Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila.
Genetics 1994;138(1):111-23.
1993: J Troy Littleton; M Stern; K Schulze; M Perin; Hugo J Bellen
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.
Cell 1993;74(6):1125-34.
1993: J Troy Littleton; Hugo J Bellen; M S Perin
Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse.
Development (Cambridge, England) 1993;118(4):1077-88.