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Dan Littman

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Gretchen E Diehl; Carolina Galan; Beatrice Breart; Adolfo Cuesta; Randy S Longman; Susan R Schwab; Jing-Xin Zhang; Dan R Littman
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.
Maria Ciofani; Carolina Galan; Alex Greenfield; Wendy Huang; Preti Jain; Francis K Kirigin; Ashish Agarwal; Carmen Birchmeier; Richard Bonneau; Kieran Mace; Aviv Madar; Sarah Meadows; Michael Muratet; Kenneth M Murphy; Richard M Myers; Kim M Newberry; Christopher N Parkurst; Florencia Pauli; MacLean Sellars; Erwin F Wagner; Yi Yang; Dan R Littman
A validated regulatory network for Th17 cell specification.
Jose U Scher; Carles Ubeda; Agnes Viale; Gerald Weissmann; Mukundan Attur; Walter A Bretz; Yvonne Buischi; Michele Equinda; Raya Khanin; Lauren Lipuma; Dan R Littman; Eric G Pamer; Michael H Pillinger; Steven B Abramson
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.

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All Publications

2013: Gretchen E Diehl; Carolina Galan; Beatrice Breart; Adolfo Cuesta; Randy S Longman; Susan R Schwab; Jing-Xin Zhang; Dan R Littman
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.
Nature 2013;494(7435):116-20.
2012: Maria Ciofani; Carolina Galan; Alex Greenfield; Wendy Huang; Preti Jain; Francis K Kirigin; Ashish Agarwal; Carmen Birchmeier; Richard Bonneau; Kieran Mace; Aviv Madar; Sarah Meadows; Michael Muratet; Kenneth M Murphy; Richard M Myers; Kim M Newberry; Christopher N Parkurst; Florencia Pauli; MacLean Sellars; Erwin F Wagner; Yi Yang; Dan R Littman
A validated regulatory network for Th17 cell specification.
Cell 2012;151(2):289-303.
2012: Jose U Scher; Carles Ubeda; Agnes Viale; Gerald Weissmann; Mukundan Attur; Walter A Bretz; Yvonne Buischi; Michele Equinda; Raya Khanin; Lauren Lipuma; Dan R Littman; Eric G Pamer; Michael H Pillinger; Steven B Abramson
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.
Arthritis and rheumatism 2012;64(10):3083-94.
2012: Jonathan M Weiss; Huizhong Xiong; Yi Yang; Ming O Li; Dan R Littman; Rachel E Niec; Soyoung Oh; Christopher N Parkhurst; Alexander Y Rudensky; Maria Grazia Ruocco; Angelina M Bilate; Maria A Curotto de Lafaille; Yi Ding; Jayashree Dolpady; Michael L Dustin; Stefan Floess; Alan B Frey; Michael Gobert; Jochen Huehn; Juan J Lafaille
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
The Journal of experimental medicine 2012;209(10):1723-42, S1.
2012: Jun R Huh; Dan R Littman
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
European journal of immunology 2012;42(9):2232-7.
2012: Monica Teta; Gabrielle Wong; Thomas Andl; Yeon Sook Choi; Mark M W Chong; Dan R Littman; Andras Nagy; Tishina Okegbe; John T Seykora; Oliver H Tam; Sarah E Millar
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.
Development (Cambridge, England) 2012;139(8):1405-16.
2012: Francis F Kirigin; Kenneth Lindstedt; Dan R Littman; Siao Li Low; Richard M Myers; Florencia Pauli; MacLean Sellars; Fiona Bell; Richard Bonneau; Maria Ciofani; Lachlan Jones; Mark M W Chong
Dynamic microRNA gene transcription and processing during T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):3257-67.
2012: Melissa A Kinnebrew; Ingrid Leiner; Dan R Littman; Charlie G Buffie; Gretchen E Diehl; Richard A Flavell; Tobias M Hohl; Lauren A Zenewicz; Eric G Pamer
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Immunity 2012;36(2):276-87.
2012: Randy S Longman; Roger K Moreira; Peter H R Green; Dan R Littman; Amrita Sethi
A rare intestinal infection with systemic effects.
Gastroenterology & hepatology 2012;8(1):60-3.
2012: Manolis Gialitakis; MacLean Sellars; Dan R Littman
The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.
Current topics in microbiology and immunology 2012;356():165-88.
2011: Dan R Littman; Eric G Pamer
Role of the commensal microbiota in normal and pathogenic host immune responses.
Cell host & microbe 2011;10(4):311-23.
2011: Nicolas Manel; Dan R Littman
Hiding in plain sight: how HIV evades innate immune responses.
Cell 2011;147(2):271-4.
2011: Olga Zhdanova; Shekhar Srivastava; Leila Tchelebi; Jiri Zavadil; Laura Barisoni; Mark M Chong; Lie Di; Sara Dworkin; Lawrence B Holzman; Duncan B Johnstone; Zhai Li; Dan R Littman; Edward Y Skolnik
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.
Kidney international 2011;80(7):719-30.
2011: Andrew Sczesnak; Nicola Segata; Dirk Gevers; Curtis Huttenhower; Dan R Littman; Joseph F Petrosino; Xiang Qin; Ivaylo I Ivanov
The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment.
Cell host & microbe 2011;10(3):260-72.
2011: Takeshi Egawa; Dan R Littman
Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14873-8.
2011: Tomohisa Sujino; Hiromasa Takaishi; Akihiko Yoshimura; Tomomitsu Doi; Atsushi Hayashi; Tadakazu Hisamatsu; Takanori Kanai; Dan R Littman; Katsuyoshi Matsuoka; Yohei Mikami; Haruhiko Ogata; Yuichi Ono; Toshifumi Hibi
Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells.
Gastroenterology 2011;141(3):1014-23.
2011: Jun R Huh; Monica W L Leung; Pengxiang Huang; Daniel A Ryan; Michael R Krout; Raghu R V Malapaka; Jonathan Chow; Nicolas Manel; Maria Ciofani; Sangwon V Kim; Adolfo Cuesta; Fabio R Santori; Juan J Lafaille; H Eric Xu; David Y Gin; Fraydoon Rastinejad; Dan R Littman
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
Nature 2011;472(7344):486-90.
2011: Amélie Collins; Susannah L Hewitt; Julie Chaumeil; MacLean Sellars; Mariann Micsinai; Jeanne Allinne; Fabio Parisi; Ephege Nora; Dan J Bolland; Anne E Corcoran; Yuval Kluger; Remy Bosselut; Wilfried Ellmeier; Mark M W Chong; Dan R Littman; Jane A Skok
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.
Immunity 2011;34(3):303-14.
2011: Hiroki Kaneko; Sami Dridi; Valeria Tarallo; Bradley D Gelfand; Benjamin J Fowler; Won Gil Cho; Mark E Kleinman; Steven L Ponicsan; William W Hauswirth; Vince A Chiodo; Katalin Karikó; Jae Wook Yoo; Dong-ki Lee; Majda Hadziahmetovic; Ying Song; Smita Misra; Gautam Chaudhuri; Frank W Buaas; Robert E Braun; David R Hinton; Qing Zhang; Hans E Grossniklaus; Jan M Provis; Michele C Madigan; Ann H Milam; Nikki L Justice; Romulo J C Albuquerque; Alexander D Blandford; Sasha Bogdanovich; Yoshio Hirano; Jassir Witta; Elaine Fuchs; Dan R Littman; Balamurali K Ambati; Charles Rudin; Mark M W Chong; Patrick Provost; Jennifer F Kugel; James A Goodrich; Joshua L Dunaief; Judit Z Baffi; Jayakrishna Ambati
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Nature 2011;471(7338):325-30.
2011: Zaruhi Hovhannisyan; Jacquelyn Treatman; Dan R Littman; Lloyd Mayer
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.
Gastroenterology 2011;140(3):957-65.
2011: Lillian Cruz-Orengo; David W Holman; Denise Dorsey; Liang Zhou; Penglie Zhang; Melissa Wright; Erin E McCandless; Jigisha R Patel; Gary D Luker; Dan R Littman; John H Russell; Robyn S Klein
CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity.
The Journal of experimental medicine 2011;208(2):327-39.
2011: Ivaylo I Ivanov; Dan R Littman
Modulation of immune homeostasis by commensal bacteria.
Current opinion in microbiology 2011;14(1):106-14.
2010: Nicolas Manel; Brandon Hogstad; Yaming Wang; David E Levy; Derya Unutmaz; Dan R Littman
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.
Nature 2010;467(7312):214-7.
2010: Mark M W Chong; Guoan Zhang; Sihem Cheloufi; Thomas A Neubert; Gregory J Hannon; Dan R Littman
Canonical and alternate functions of the microRNA biogenesis machinery.
Genes & development 2010;24(17):1951-60.
2010: Hsin-Jung Wu; Ivaylo I Ivanov; Jaime Darce; Kimie Hattori; Tatsuichiro Shima; Yoshinori Umesaki; Dan R Littman; Christophe Benoist; Diane Mathis
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.
Immunity 2010;32(6):815-27.
2010: Ivaylo I Ivanov; Dan R Littman
Segmented filamentous bacteria take the stage.
Mucosal immunology 2010;3(3):209-12.
2010: Sofia Buonocore; Philip P Ahern; HH Uhlig; Ivaylo I Ivanov; Dan R Littman; Kevin J Maloy; Fiona Powrie
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Nature 2010;464(7293):1371-5.
2010: Mark M W Chong; Natalie Simpson; Maria Ciofani; Grace Chen; Amélie Collins; Dan R Littman
Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.
Genes & development 2010;24(7):659-69.
2010: Dan R Littman; Alexander Y Rudensky
Th17 and regulatory T cells in mediating and restraining inflammation.
Cell 2010;140(6):845-58.
2010: KyeongEun Lee; Zandrea Ambrose; Thomas D Martin; Ilker Oztop; Alok Mulky; John G Julias; Nick Vandegraaff; Joerg G Baumann; Rui Wang; Wendy Yuen; Taichiro Takemura; Kenneth Shelton; Ichiro Taniuchi; Yuan Li; Joseph Sodroski; Dan R Littman; John M Coffin; Stephen H Hughes; Derya Unutmaz; Alan Engelman; Vineet N KewalRamani
Flexible use of nuclear import pathways by HIV-1.
Cell host & microbe 2010;7(3):221-33.
2010: Aimee El Hed; Alka Khaitan; Lina Kozhaya; Nicolas Manel; Demetre Daskalakis; William Borkowsky; Fred Valentine; Dan R Littman; Derya Unutmaz
Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.
The Journal of infectious diseases 2010;201(6):843-54.
2010: Bindya Jacob; Motomi Osato; Namiko Yamashita; Chelsia Qiuxia Wang; Ichiro Taniuchi; Dan R Littman; Norio Asou; Yoshiaki Ito
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
Blood 2010;115(8):1610-20.
2010: Paul Trampont; Annie-Carole Tosello-Trampont; Yuelei Shen; Amanda K Duley; Ann E Sutherland; Timothy P Bender; Dan R Littman; Kodi S Ravichandran
CXCR4 acts as a costimulator during thymic beta-selection.
Nature immunology 2010;11(2):162-70.
2009: Sven Klunker; Mark M W Chong; Pierre-Yves Mantel; Oscar Palomares; Claudio Bassin; Mario Ziegler; Beate Rückert; Flurina Meiler; Mübeccel Akdis; Dan R Littman; Cezmi A. Akdis
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells.
The Journal of experimental medicine 2009;206(12):2701-15.
2009: Dipayan Rudra; Takeshi Egawa; Mark M W Chong; piper meigs treuting; Dan R Littman; Alexander Y Rudensky
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells.
Nature immunology 2009;10(11):1170-7.
2009: Ivaylo I Ivanov; Koji Atarashi; Nicolas Manel; Eoin L Brodie; Tatsuichiro Shima; Ulas Karaoz; Dongguang Wei; Katherine C Goldfarb; Clark A Santee; Susan V Lynch; Takeshi Tanoue; Akemi Imaoka; Kikuji Itoh; Kiyoshi Takeda; Yoshinori Umesaki; Kenya Honda; Dan R Littman
Induction of intestinal Th17 cells by segmented filamentous bacteria.
Cell 2009;139(3):485-98.
2009: Markus Feuerer; Yuelei Shen; Dan R Littman; Christophe Benoist; Diane Mathis
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.
Immunity 2009;31(4):654-64.
2009: Liang Zhou; Mark M W Chong; Dan R Littman
Plasticity of CD4+ T cell lineage differentiation.
Immunity 2009;30(5):646-55.
2009: Liang Zhou; Dan R Littman
Transcriptional regulatory networks in Th17 cell differentiation.
Current opinion in immunology 2009;21(2):146-52.
2009: Kui Shin Voo; Yui-Hsi Wang; Fabio R Santori; Cesar Boggiano; Yui-Hsi Wang; Kazuhiko Arima; Laura Bover; Shino Hanabuchi; Jahan Khalili; Ekaterina Marinova; B Zheng; Dan R Littman; Yong-Jun Liu
Identification of IL-17-producing FOXP3+ regulatory T cells in humans.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4793-8.
2009: Edward P Browne; Dan R Littman
Myd88 is required for an antibody response to retroviral infection.
PLoS pathogens 2009;5(2):e1000298.
2009: Amélie Collins; Dan R Littman; Ichiro Taniuchi
RUNX proteins in transcription factor networks that regulate T-cell lineage choice.
Nature reviews. Immunology 2009;9(2):106-15.
2009: Hiroaki Takatori; Yuka Kanno; Wendy T Watford; Cristina M Tato; Greta Weiss; Ivaylo I Ivanov; Dan R Littman; John O'Shea
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.
The Journal of experimental medicine 2009;206(1):35-41.
2009: Joong Kyu Kim; Mark Klinger; Jonathan Benjamin; Yuanyuan Xiao; David J Erle; Dan R Littman; Nigel Killeen
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking.
PloS one 2009;4(8):e6580.
2009: Nico Michel; Christine Goffinet; Kerstin Ganter; Ina Allespach; Vineet N KewalRamani; Mohammed Saifuddin; Dan R Littman; Warner Greene; Mark A Goldsmith; Oliver T Keppler
Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.
Retrovirology 2009;6():2.
2009: Carmelo Luci; Ana Reynders; Ivaylo I Ivanov; Celine Cognet; Laurent Chiche; Lionel Chasson; Jean Hardwigsen; Esperanza Anguiano; Jacques Banchereau; Damien Chaussabel; Marc Dalod; Dan R Littman; Eric Vivier; Elena Tomasello
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.
Nature immunology 2009;10(1):75-82.
2009: Moritz Leppkes; Christoph Becker; Ivaylo I Ivanov; Sebastian Hirth; Stefan Wirtz; Clemens Neufert; Sandrine Pouly; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Burkhard Becher; Dan R Littman; Markus F Neurath
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.
Gastroenterology 2009;136(1):257-67.
2008: Henry Kao; Joseph Lin; Dan R Littman; Andrey S Shaw; Paul M Allen
Regulated movement of CD4 in and out of the immunological synapse.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8248-57.
2008: Ilaria Tassi; Marina Cella; Rachel Presti; Angela Colucci; Susan Gilfillan; Dan R Littman; Marco COLONna
NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.
Blood 2008;112(10):4109-16.
2008: Ivaylo I Ivanov; Rosa de Llanos Frutos; Nicolas Manel; Keiji Yoshinaga; Daniel B Rifkin; Ryan Sartor; B Brett Finlay; Dan R Littman
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.
Cell host & microbe 2008;4(4):337-49.
2008: Ruslan Medzhitov; Dan R Littman
HIV immunology needs a new direction.
Nature 2008;455(7213):591.
2008: Takeshi Egawa; Dan R Littman
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage.
Nature immunology 2008;9(10):1131-9.
2008: Olaf Gross; Christina Grupp; Christian Steinberg; Stephanie Zimmermann; Dominikus Strasser; Nicole Hannesschläger; Wolfgang Reindl; Helena Jonsson; Hairong Huo; Dan R Littman; Christian Peschel; Wayne M Yokoyama; Anne Krug; Jürgen Ruland
Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
Blood 2008;112(6):2421-8.
2008: Mark M W Chong; Jeffrey P Rasmussen; Alexander Y Rudensky; Alexander Y Rundensky; Dan R Littman
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.
The Journal of experimental medicine 2008;205(9):2005-17.
2008: Sergio Quezada; Karl S Peggs; Tyler R Simpson; Yuelei Shen; Dan R Littman; James P Allison
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
The Journal of experimental medicine 2008;205(9):2125-38.
2008: Masayuki Tsuji; Keiichiro Suzuki; Hiroshi Kitamura; Mikako Maruya; Kazuo Kinoshita; Ivaylo I Ivanov; Kikuji Itoh; Dan R Littman; Sidonia Fagarasan
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.
Immunity 2008;29(2):261-71.
2008: Yanet Valdez; Gretchen E. Diehl; Bruce A Vallance; Guntram A Grassl; Julian A Guttman; Nat F Brown; Carrie M Rosenberger; Dan R Littman; Philippe Gros; B Brett Finlay
Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.
Cellular microbiology 2008;10(8):1646-61.
2008: Nicolas Manel; Derya Unutmaz; Dan R Littman
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat.
Nature immunology 2008;9(6):641-9.
2008: Elke Scandella; Beatrice Bolinger; Evelyn Lattmann; Simone Miller; Stéphanie Favre; Dan R Littman; Daniela Finke; Sanjiv A Luther; Tobias Junt; Burkhard Ludewig
Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone.
Nature immunology 2008;9(6):667-75.
2008: Liang Zhou; Jared E Lopes; Mark M W Chong; Ivaylo I Ivanov; Roy Min; Gabriel Victora; Yuelei Shen; Jianguang Du; Yuri P Rubtsov; Alexander Y Rudensky; Steven F Ziegler; Dan R Littman
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
Nature 2008;453(7192):236-40.
2008: Edward P Browne; Dan R Littman
Species-specific restriction of apobec3-mediated hypermutation.
Journal of virology 2008;82(3):1305-13.
2008: Jing-xin Zhang; Gretchen E. Diehl; Dan R Littman
Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.
PloS one 2008;3(4):e2035.
2008: Takeshi Egawa; Taras Kreslavsky; Dan R Littman; Harald von Boehmer
Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.
PloS one 2008;3(1):e1512.
2007: Ivaylo I Ivanov; Liang Zhou; Dan R Littman
Transcriptional regulation of Th17 cell differentiation.
Seminars in immunology 2007;19(6):409-17.
2007: Lena Motoda; Motomi Osato; Namiko Yamashita; Bindya Jacob; Lynnette Q Chen; Masatoshi Yanagida; Hiroshi Ida; Hee-Jun Wee; Alfred X Sun; Ichiro Taniuchi; Dan R Littman; Yoshiaki Ito
Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.
Stem cells (Dayton, Ohio) 2007;25(12):2976-86.
2007: Liang Zhou; Ivaylo I Ivanov; Rosanne Spolski; Roy Min; Kevin Shenderov; Takeshi Egawa; David E Levy; Warren J Leonard; Dan R Littman
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Nature immunology 2007;8(9):967-74.
2007: Takeshi Egawa; Robert E Tillman; Yoshinori Naoe; Ichiro Taniuchi; Dan R Littman
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.
The Journal of experimental medicine 2007;204(8):1945-57.
2007: Yoshinori Naoe; Ruka Setoguchi; Kaori Akiyama; Sawako Muroi; Masahiko Kuroda; Farah Hatam; Dan R Littman; Ichiro Taniuchi
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer.
The Journal of experimental medicine 2007;204(8):1749-55.
2007: Ravi S Misra; Jennifer Q Russell; Andreas Koenig; Jennifer A Hinshaw-Makepeace; Renren Wen; Demin Wang; Hairong Huo; Dan R Littman; Uta Ferch; Jürgen Ruland; Margot Thome; Ralph C Budd
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
The Journal of biological chemistry 2007;282(27):19365-74.
2007: Tasha Sims; Timothy J Soos; Harry S Xenias; Benjamin J Dubin-Thaler; Jake M Hofman; Janelle C Waite; Thomas O Cameron; V Kaye Thomas; Rajat Varma; Chris H Wiggins; Michael P Sheetz; Dan R Littman; Michael L Dustin
Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.
Cell 2007;129(4):773-85.
2007: Dan R Littman; Harinder Singh
Immunology. Asymmetry and immune memory.
Science (New York, N.Y.) 2007;315(5819):1673-4.
2007: Cesar Boggiano; Nicolas Manel; Dan R Littman
Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN.
Journal of virology 2007;81(5):2519-23.
2007: Cesar Boggiano; Dan R Littman
HIV's vagina travelogue.
Immunity 2007;26(2):145-7.
2006: Ivaylo I Ivanov; Brent S McKenzie; Liang Zhou; Carlos E Tadokoro; Alice Lepelley; Juan J Lafaille; Daniel J Cua; Dan R Littman
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Cell 2006;126(6):1121-33.
2006: Jennifer M Burns; Bretton C Summers; Yu Wang; Anita Melikian; Robert D Berahovich; Zhenhua Miao; Mark E T Penfold; Mary Jean Sunshine; Dan R Littman; Calvin J Kuo; Kevin Wei; Brian E McMaster; Kim Wright; Maureen C Howard; Thomas J Schall
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
The Journal of experimental medicine 2006;203(9):2201-13.
2006: Timothy J Soos; Tasha Sims; Laura Barisoni; K Lin; Dan R Littman; Michael L Dustin; Peter J Nelson
CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.
Kidney international 2006;70(3):591-6.
2006: Astrid E Cardona; Erik P Pioro; Margaret E Sasse; Volodymyr Kostenko; Sandra M Cardona; Ineke M Dijkstra; Deren Huang; Grahame J Kidd; Stephen Dombrowski; Ranjan Dutta; Jar-Chi Lee; Donald N Cook; Steffen Jung; sergio lira; Dan R Littman; Richard M Ransohoff
Control of microglial neurotoxicity by the fractalkine receptor.
Nature neuroscience 2006;9(7):917-24.
2006: DeRen Huang; Fu-Dong Shi; Steffen Jung; Gary C Pien; Jintang Wang; Thais P Salazar-Mather; Toby T He; Jennifer T Weaver; Hans-Gustaf Ljunggren; Christine A Biron; Dan R Littman; Richard M Ransohoff
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):896-905.
2006: Jinglin Sun; Timothy Soos; Vineet N KewalRamani; Kristin Osiecki; Jian Hua Zheng; Laurie Falkin; Laura Santambrogio; Dan R Littman; Harris Goldstein
CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate.
Journal of virology 2006;80(4):1850-62.
2006: Darin K Fogg; Claire Sibon; Chaouki Miled; Steffen Jung; Pierre Aucouturier; Dan R Littman; Ana Cumano; Frederic Geissmann
A clonogenic bone marrow progenitor specific for macrophages and dendritic cells.
Science (New York, N.Y.) 2006;311(5757):83-7.
2006: Ivaylo I Ivanov; Gretchen E. Diehl; Dan R Littman
Lymphoid tissue inducer cells in intestinal immunity.
Current topics in microbiology and immunology 2006;308():59-82.
2005: Veysel Odemis; Elke Lamp; Gita Pezeshki; Barbara Moepps; Karl Schilling; Peter Gierschik; Dan R Littman; Jürgen Engele
Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis.
Molecular and cellular neurosciences 2005;30(4):494-505.
2005: Tami Zaft; Anita Sapoznikov; Rita Krauthgamer; Dan R Littman; Steffen Jung
CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6428-35.
2005: Tim O Vilz; Barbara Moepps; Jürgen Engele; Sabine Molly; Dan R Littman; Karl Schilling
The SDF-1/CXCR4 pathway and the development of the cerebellar system.
The European journal of neuroscience 2005;22(8):1831-9.
2005: Baerbel Grueter; Michaela Petter; Takeshi Egawa; Kirsten Laule-Kilian; Christine J Aldrian; Andreas Wuerch; Yvonne Ludwig; Hidehiro Fukuyama; Hedda Wardemann; Ralph Waldschuetz; Tarik Möröy; Ichiro Taniuchi; Viktor Steimle; Dan R Littman; Marc Ehlers
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1694-705.
2005: Xiaoxia Wang; Chris S Blagden; Jihua Fan; Scott J Nowak; Ichiro Taniuchi; Dan R Littman; Steven J Burden
Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle.
Genes & development 2005;19(14):1715-22.
2005: Amélie Collins; Dan R Littman
Selection and lineage specification in the thymus: commitment 4-stalled.
Immunity 2005;23(1):4-5.
2005: Takeshi Egawa; Gérard Eberl; Ichiro Taniuchi; Kamel Benlagha; Frederic Geissmann; Lothar Hennighausen; Albert Bendelac; Dan R Littman
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors.
Immunity 2005;22(6):705-16.
2005: Dimitrios Davalos; Jaime Grutzendler; Guang Yang; Jiyun V Kim; Yi Zuo; Steffen Jung; Dan R Littman; Michael L Dustin; Wen-Biao Gan
ATP mediates rapid microglial response to local brain injury in vivo.
Nature neuroscience 2005;8(6):752-8.
2005: Frederic Geissmann; Thomas O Cameron; Stephane Sidobre; Natasha Manlongat; Mitchell Kronenberg; Michael J Briskin; Michael L Dustin; Dan R Littman
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids.
PLoS biology 2005;3(4):e113.
2005: Nicholas Feik; Ivan Bilic; Johanna Tinhofer; Bernd Unger; Dan R Littman; Wilfried Ellmeier
Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1513-24.
2005: Niess Jan; Stephan Brand; Xiubin Gu; Limor Landsman; Steffen Jung; Beth A McCormick; Jatin M Vyas; Marianne Boes; Hidde L Ploegh; James G Fox; Dan R Littman; Hans-Christian Reinecker
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
Science (New York, N.Y.) 2005;307(5707):254-8.
2005: Edward P Browne; Junjie Li; Mark Chong; Dan R Littman
Virus-host interactions: new insights from the small RNA world.
Genome biology 2005;6(11):238.
2005: Tohru Sato; Henrik Thorlacius; Brent Johnston; Tracy L Staton; Wenkai Xiang; Dan R Littman; Eugene C Butcher
Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):277-83.
2004: Yuko Kawakami; Hajime Nishimoto; Jiro Kitaura; Mari Maeda-Yamamoto; Roberta M Kato; Dan R Littman; Michael Leitges; David J Rawlings; Toshiaki Kawakami
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
The Journal of biological chemistry 2004;279(46):47720-5.
2004: Yuchun Nie; Janelle Waite; Faraha Brewer; Mary Jean Sunshine; Dan R Littman; Yong-Rui Zou
The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity.
The Journal of experimental medicine 2004;200(9):1145-56.
2004: Jörg G Baumann; Derya Unutmaz; Michael D Miller; Sabine K J Breun; Stacy M Grill; Jane Mirro; Dan R Littman; Alan Rein; Vineet N KewalRamani
Murine T cells potently restrict human immunodeficiency virus infection.
Journal of virology 2004;78(22):12537-47.
2004: Yu Li; Timothy J Soos; Xinghai Li; Jiong Wu; Matthew Degennaro; Xiao Jian Sun; Dan R Littman; Morris J Birnbaum; Roberto D Polakiewicz
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
The Journal of biological chemistry 2004;279(44):45304-7.
2004: Jason K Kim; Jonathan J Fillmore; Mary Jean Sunshine; Bjoern Albrecht; Takamasa Higashimori; Dong-Wook Kim; Zhen-Xiang Liu; Timothy J Soos; Gary W Cline; William R O'Brien; Dan R Littman; Gerald I Shulman
PKC-theta knockout mice are protected from fat-induced insulin resistance.
The Journal of clinical investigation 2004;114(6):823-7.
2004: Benjamin J Marsland; Timothy J Soos; Gerald Späth; Dan R Littman; Manfred Kopf
Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses.
The Journal of experimental medicine 2004;200(2):181-9.
2004: Gérard Eberl; Dan R Littman
Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells.
Science (New York, N.Y.) 2004;305(5681):248-51.
2004: Ichiro Taniuchi; Dan R Littman
Epigenetic gene silencing by Runx proteins.
Oncogene 2004;23(24):4341-5.
2004: Jean-François Fonteneau; Marie Larsson; Anne-Sophie Beignon; Kelli McKenna; Ida Dasilva; Ali Amara; Yong-Jun Liu; Jeffrey D Lifson; Dan R Littman; Nina Bhardwaj
Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells.
Journal of virology 2004;78(10):5223-32.
2004: Loui Madakamutil; Urs Christen; Christopher J Lena; Yiran Wang-Zhu; Antoine Attinger; Monisha Sundarrajan; Wilfried Ellmeier; Matthias G von Herrath; Peter Jensen; Dan R Littman; Hilde Cheroutre
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
Science (New York, N.Y.) 2004;304(5670):590-3.
2004: Nancy N Berg-Brown; Matthew A Gronski; Russell G Jones; Alisha R Elford; Elissa K Deenick; Bernhard Odermatt; Dan R Littman; Pamela S Ohashi
PKCtheta signals activation versus tolerance in vivo.
The Journal of experimental medicine 2004;199(6):743-52.
2004: Ichiro Taniuchi; Wilfried Ellmeier; Dan R Littman
The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development.
Advances in immunology 2004;83():55-89.
2004: Gérard Eberl; Shana Marmon; Mary Jean Sunshine; Paul D Rennert; Yongwon Choi; Dan R Littman
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.
Nature immunology 2004;5(1):64-73.
2003: Gérard Eberl; Dan R Littman
The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches.
Immunological reviews 2003;195():81-90.
2003: Kathleen Molyneaux; Hélène Zinszner; Prabhat S Kunwar; Kyle Schaible; Jürg Stebler; Mary Jean Sunshine; William O'Brien; erez raz; Dan R Littman; Chris Wylie; Ruth Lehmann
The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival.
Development (Cambridge, England) 2003;130(18):4279-86.
2003: Ali Amara; Dan R Littman
After Hrs with HIV.
The Journal of cell biology 2003;162(3):371-5.
2003: Takeshi Egawa; Björn Albrecht; Benoit Favier; Mary Jean Sunshine; Kanchan Mirchandani; William O'Brien; Margot Thome; Dan R Littman
Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation.
Current biology : CB 2003;13(14):1252-8.
2003: Frederic Geissmann; Steffen Jung; Dan R Littman
Blood monocytes consist of two principal subsets with distinct migratory properties.
Immunity 2003;19(1):71-82.
2003: Sreekanth H Chalasani; Frédéric Baribaud; Christine M Coughlan; Mary J Sunshine; Virginia M-Y Lee; Robert W Doms; Dan R Littman; Jonathan A Raper
The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4601-12.
2003: Sreekanth H Chalasani; Kimberly A Sabelko; Mary J Sunshine; Dan R Littman; Jonathan A Raper
A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(4):1360-71.
2003: Yuqing Huo; Andreas Schober; S Bradley Forlow; David F Smith; Matthew Craig Hyman; Steffen Jung; Dan R Littman; Christian Weber; Klaus Ley
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.
Nature medicine 2003;9(1):61-7.
2002: Ichiro Taniuchi; Motomi Osato; Takeshi Egawa; Mary Jean Sunshine; Suk-Chul Bae; Toshihisa Komori; Yoshiaki Ito; Dan R Littman
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.
Cell 2002;111(5):621-33.
2002: Ichiro Taniuchi; Mary Jean Sunshine; Richard Festenstein; Dan R Littman
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.
Molecular cell 2002;10(5):1083-96.
2002: Wiebke Ohlrogge; Friedrich Haag; Jürgen Löhler; Michel Seman; Dan R Littman; Nigel Killeen; Friedrich Koch-Nolte
Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
Molecular and cellular biology 2002;22(21):7535-42.
2002: Anil Bagri; Theresa Gurney; Xiaoping He; Yong-Rui Zou; Dan R Littman; Marc Tessier-Lavigne; Samuel J Pleasure
The chemokine SDF1 regulates migration of dentate granule cells.
Development (Cambridge, England) 2002;129(18):4249-60.
2002: Steffen Jung; Derya Unutmaz; Phillip Wong; Gen-Ichiro Sano; Kenia De los Santos; Tim D. Sparwasser; Shengji Wu; Srilatha Vuthoori; Kyung Ko; Fidel Zavala; Eric G Pamer; Dan R Littman; Richard Lang
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Immunity 2002;17(2):211-20.
2002: Tian H Chi; Mimi Wan; Keji Zhao; Ichiro Taniuchi; Lei Chen; Dan R Littman; Gerald R Crabtree
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
Nature 2002;418(6894):195-9.
2002: Takaharu Okada; Vu N Ngo; Eric H Ekland; Reinhold Förster; Martin Lipp; Dan R Littman; Jason G Cyster
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches.
The Journal of experimental medicine 2002;196(1):65-75.
2002: Christopher W Arendt; Björn Albrecht; Timothy J Soos; Dan R Littman
Protein kinase C-theta;: signaling from the center of the T-cell synapse.
Current opinion in immunology 2002;14(3):323-30.
2002: Wilfried Ellmeier; Mary Jean Sunshine; Romana Maschek; Dan R Littman
Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression.
Immunity 2002;16(5):623-34.
2002: Jian Guo; Abbas Hawwari; Hong Li; Zuoming Sun; Sanjeev K Mahanta; Dan R Littman; Michael S Krangel; You-Wen He
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.
Nature immunology 2002;3(5):469-76.
2002: Astar Winoto; Dan R Littman
Nuclear hormone receptors in T lymphocytes.
Cell 2002;109 Suppl():S57-66.
2002: Oliver T Keppler; Frank Welte; Tuan A Ngo; Peggy S Chin; Kathryn S Patton; Chia-Lin Tsou; Nancy W Abbey; Mark E Sharkey; Robert M Grant; Yun You; John D Scarborough; Wilfried Ellmeier; Dan R Littman; Mario Stevenson; Israel F Charo; Brian G Herndier; Roberto F Speck; Mark A Goldsmith
Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
The Journal of experimental medicine 2002;195(6):719-36.
2002: Allen G Harmsen; Kim Kusser; Louise Hartson; Michael Tighe; Mary Jean Sunshine; Jonathon D Sedgwick; Yongwon Choi; Dan R Littman; Troy D Randall
Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):986-90.
2002: Douglas S Kwon; G Glenn Gregorio; Natacha Bitton; Wayne A Hendrickson; Dan R Littman
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection.
Immunity 2002;16(1):135-44.
2001: Roger Palframan; S Jung; Guiying Cheng; Wolfgang Weninger; Yi Luo; Martin E Dorf; Dan R Littman; Barrett J Rollins; H Zweerink; A Rot; Ulrich H von Andrian
Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues.
The Journal of experimental medicine 2001;194(9):1361-73.
2001: Yuqing Huo; Christian Weber; S Bradley Forlow; Markus Sperandio; Jayant Thatte; M Mack; S Jung; Dan R Littman; Klaus Ley
The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium.
The Journal of clinical investigation 2001;108(9):1307-14.
2001: Yong-Rui Zou; Mary Jean Sunshine; Ichiro Taniuchi; Farah Hatam; N Killeen; Dan R Littman
Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage.
Nature genetics 2001;29(3):332-6.
2001: Frédéric Baribaud; Stefan Pöhlmann; Tim D. Sparwasser; M T Kimata; Y K Choi; Beth Haggarty; Navid Ahmad; Todd Macfarlan; Terri G Edwards; George J Leslie; J Arnason; T A Reinhart; J T Kimata; Dan R Littman; James A Hoxie; Robert W Doms
Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.
Journal of virology 2001;75(21):10281-9.
2001: Diana C Hargreaves; PL Hyman; Theresa T Lu; Vu N Ngo; Afshin Bidgol; G Suzuki; Y R Zou; Dan R Littman; Jason G Cyster
A coordinated change in chemokine responsiveness guides plasma cell movements.
The Journal of experimental medicine 2001;194(1):45-56.
2001: Anita Wolfer; Talitha Bakker; Anne Wilson; Michael Nicolas; Vassilios Ioannidis; Dan R Littman; P P Lee; C B Wilson; Werner Held; H Robson MacDonald; Freddy Radtke
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.
Nature immunology 2001;2(3):235-41.
2001: Catherine Browning; MJ Smith; Nina M Clark; Brian R Lane; C Parada; M Montano; V N KewalRamani; Dan R Littman; M Essex; R G Roeder; David M Markovitz
Human GLI-2 is a tat activation response element-independent Tat cofactor.
Journal of virology 2001;75(5):2314-23.
2001: Alessandra Pierani; L Moran-Rivard; Mary Jean Sunshine; Dan R Littman; Martyn Goulding; Thomas M Jessell
Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1.
Neuron 2001;29(2):367-84.
2001: Christopher W Arendt; Dan R Littman
HIV: master of the host cell.
Genome biology 2001;2(11):REVIEWS1030.
2000: Wilfried Ellmeier; S Jung; Mary Jean Sunshine; Farah Hatam; Y Xu; David Baltimore; H Mano; Dan R Littman
Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.
The Journal of experimental medicine 2000;192(11):1611-24.
2000: Derya Unutmaz; W Xiang; Mary Jean Sunshine; J Campbell; E Butcher; Dan R Littman
The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3284-92.
2000: C Gu; Yong-Chao Ma; J Benjamin; Dan R Littman; M V Chao; X Y Huang
Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway.
The Journal of biological chemistry 2000;275(27):20726-33.
2000: Z Sun; Derya Unutmaz; Yong-Rui Zou; Mary Jean Sunshine; Alessandra Pierani; Susan Brenner-Morton; R E Mebius; Dan R Littman
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
Science (New York, N.Y.) 2000;288(5475):2369-73.
2000: S Jung; Julio Aliberti; P Graemmel; Mary Jean Sunshine; G W Kreutzberg; A Sher; Dan R Littman
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.
Molecular and cellular biology 2000;20(11):4106-14.
2000: Z Sun; Christopher W Arendt; Wilfried Ellmeier; Edward M Schaeffer; Mary Jean Sunshine; L Gandhi; Justin P Annes; D Petrzilka; Abraham Kupfer; Pamela L Schwartzberg; Dan R Littman
PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes.
Nature 2000;404(6776):402-7.
2000: Teunis B H Geijtenbeek; D S Kwon; Ruurd Torensma; Sandra J van Vliet; Gerard van Duijnhoven; Jeena Middel; I L Cornelissen; Hans S L M Nottet; Vineet N KewalRamani; Dan R Littman; Carl G Figdor; Yvette van Kooyk
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
Cell 2000;100(5):587-97.
1999: K Vidal; C Daniel; M Hill; Dan R Littman; Paul M Allen
Differential requirements for CD4 in TCR-ligand interactions.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4811-8.
1999: DJ Fowell; Kanade Shinkai; X C Liao; Amy M Beebe; Robert L Coffman; Dan R Littman; Richard M Locksley
Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
Immunity 1999;11(4):399-409.
1999: Derya Unutmaz; Vineet N KewalRamani; Shana Marmon; Dan R Littman
Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes.
The Journal of experimental medicine 1999;189(11):1735-46.
1999: S Jung; Dan R Littman
Chemokine receptors in lymphoid organ homeostasis.
Current opinion in immunology 1999;11(3):319-25.
1999: P F Shelbourne; N Killeen; Robert Hevner; H M Johnston; Laurence H Tecott; M Lewandoski; M Ennis; Lucia Ramirez; Z Li; C Iannicola; Dan R Littman; Richard Myers
A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice.
Human molecular genetics 1999;8(5):763-74.
1999: EM Schaeffer; Jayanta Debnath; G Yap; Daniel W McVicar; X C Liao; Dan R Littman; Alan Sher; Harold Varmus; Michael J Lenardo; Pamela L Schwartzberg
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.) 1999;284(5414):638-41.
1999: Andreas Mörner; Asa Björndal; Jan Albert; V N Kewalramani; Dan R Littman; R Inoue; Rigmor Thorstensson; Eva Maria Fenyö; Ewa Björling
Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage.
Journal of virology 1999;73(3):2343-9.
1999: Jason T Kimata; John J Gosink; Vineet N KewalRamani; LM Rudensey; Dan R Littman; Julie Overbaugh
Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne.
Journal of virology 1999;73(2):1655-60.
1999: RA LaCasse; Kathryn E Follis; Meg Trahey; J D Scarborough; Dan R Littman; Jack H Nunberg
Fusion-competent vaccines: broad neutralization of primary isolates of HIV.
Science (New York, N.Y.) 1999;283(5400):357-62.
1999: Dan R Littman; Z Sun; Derya Unutmaz; Mary Jean Sunshine; H T Petrie; Yong-Rui Zou
Role of the nuclear hormone receptor ROR gamma in transcriptional regulation, thymocyte survival, and lymphoid organogenesis.
Cold Spring Harbor symposia on quantitative biology 1999;64():373-81.
1999: Wilfried Ellmeier; S Sawada; Dan R Littman
The regulation of CD4 and CD8 coreceptor gene expression during T cell development.
Annual review of immunology 1999;17():523-54.
1998: Mitchell E Garber; P Wei; V N KewalRamani; TP Mayall; Christine H Herrmann; Andrew P Rice; Dan R Littman; Katherine A Jones
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.
Genes & development 1998;12(22):3512-27.
1998: YJ Zhang; Tanya Dragic; Yunzhen Cao; Leondios G Kostrikis; D S Kwon; Dan R Littman; Vineet N KewalRamani; John P Moore
Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.
Journal of virology 1998;72(11):9337-44.
1998: Wilfried Ellmeier; Mary Jean Sunshine; Kasia Losos; Dan R Littman
Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.
Immunity 1998;9(4):485-96.
1998: CM Hill; D Kwon; M Jones; C B Davis; Shana Marmon; Bruce L Daugherty; Julie A DeMartino; Martin S Springer; Derya Unutmaz; Dan R Littman
The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins.
Virology 1998;248(2):357-71.
1998: Dayaraj Cecilia; Vineet N KewalRamani; J O'Leary; Barbara Volsky; Phillipe N Nyambi; Sherri Burda; S Xu; Dan R Littman; Susan Zolla-Pazner
Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usage.
Journal of virology 1998;72(9):6988-96.
1998: Isabelle Riviere; Mary Jean Sunshine; Dan R Littman
Regulation of IL-4 expression by activation of individual alleles.
Immunity 1998;9(2):217-28.
1998: A J Langlois; Ronald C Desrosiers; M G Lewis; V N KewalRamani; Dan R Littman; JY Zhou; Kelledy Manson; Michael S Wyand; Dani P Bolognesi; David C Montefiori
Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus.
Journal of virology 1998;72(8):6950-5.
1998: Hanna Yoko Irie; M S Mong; A Itano; M E Crooks; Dan R Littman; Steven J Burakoff; Ellen A Robey
The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):183-91.
1998: Nelson L Michael; Julie A E Nelson; Vineet N KewalRamani; G Chang; S J O'Brien; John R Mascola; Barbara Volsky; Mark K Louder; Gilbert C White; Dan R Littman; Ronald Swanstrom; Thomas R O'Brien
Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.
Journal of virology 1998;72(7):6040-7.
1998: Yong-Rui Zou; Andreas Kottmann; M Kuroda; Ichiro Taniuchi; Dan R Littman
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.
Nature 1998;393(6685):595-9.
1998: Derya Unutmaz; Vineet N KewalRamani; Dan R Littman
G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models.
Seminars in immunology 1998;10(3):225-36.
1998: Dan R Littman
Chemokine receptors: keys to AIDS pathogenesis?
Cell 1998;93(5):677-80.
1998: Alexandra Trkola; Thomas J Ketas; Vineet N KewalRamani; F Endorf; James M Binley; Hermann Katinger; J Robinson; Dan R Littman; John P Moore
Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage.
Journal of virology 1998;72(3):1876-85.
1998: C Tscherning; A Alaeus; R Fredriksson; Asa Björndal; H Deng; Dan R Littman; Eva Maria Fenyö; Jan Albert
Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.
Virology 1998;241(2):181-8.
1998: Edward A Berger; R W Doms; E M Fenyö; B T Korber; Dan R Littman; J P Moore; Quentin J Sattentau; H Schuitemaker; Joseph Sodroski; R A Weiss
A new classification for HIV-1.
Nature 1998;391(6664):240.
1997: X C Liao; Dan R Littman; Arthur Weiss
Itk and Fyn make independent contributions to T cell activation.
The Journal of experimental medicine 1997;186(12):2069-73.
1997: C B Davis; I Dikic; Derya Unutmaz; CM Hill; J Arthos; M A Siani; D A Thompson; J Schlessinger; Dan R Littman
Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.
The Journal of experimental medicine 1997;186(10):1793-8.
1997: Gabriella Scarlatti; Eleonora Tresoldi; Asa Björndal; R Fredriksson; C Colognesi; H K Deng; Mauro S Malnati; Alessandro Plebani; Antonio G Siccardi; Dan R Littman; Eva Maria Fenyö; Paolo Lusso
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.
Nature medicine 1997;3(11):1259-65.
1997: Wilfried Ellmeier; Mary Jean Sunshine; Kasia Losos; Farah Hatam; Dan R Littman
An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.
Immunity 1997;7(4):537-47.
1997: Asa Björndal; H Deng; Marianne Jansson; J R Fiore; C Colognesi; A Karlsson; Jan Albert; Gabriella Scarlatti; Dan R Littman; Eva Maria Fenyö
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
Journal of virology 1997;71(10):7478-87.
1997: Martin F Bachmann; Dan R Littman; X C Liao
Antiviral immune responses in Itk-deficient mice.
Journal of virology 1997;71(10):7253-7.
1997: Udaykumar Ranga; C Woffendin; ZY Yang; Li Xu; S Verma; Dan R Littman; Gary Nabel
Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene.
Journal of virology 1997;71(9):7020-9.
1997: CM Hill; H Deng; Derya Unutmaz; Vineet N KewalRamani; Lisa Lallos; Miroslaw K Gorny; Susan Zolla-Pazner; Dan R Littman
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
Journal of virology 1997;71(9):6296-304.
1997: X C Liao; S Fournier; Nigel Killeen; Arthur Weiss; James P Allison; Dan R Littman
Itk negatively regulates induction of T cell proliferation by CD28 costimulation.
The Journal of experimental medicine 1997;186(2):221-8.
1997: H K Deng; Derya Unutmaz; Vineet N KewalRamani; Dan R Littman
Expression cloning of new receptors used by simian and human immunodeficiency viruses.
Nature 1997;388(6639):296-300.
1997: Derya Unutmaz; Dan R Littman
Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1615-8.
1997: Soo-Jeet Teh; Nigel Killeen; Alexander Tarakhovsky; Dan R Littman; Hung-Sia Teh
CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.
Blood 1997;89(4):1308-18.
1996: R E Sutton; Dan R Littman
Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system.
Journal of virology 1996;70(10):7322-6.
1996: C M Hill; Dan R Littman
Natural resistance to HIV?
Nature 1996;382(6593):668-9.
1996: H Deng; R Liu; Wilfried Ellmeier; S Choe; Derya Unutmaz; M Burkhart; P Di Marzio; S Marmon; R E Sutton; C M Hill; C B Davis; Stephen Peiper; T J Schall; Dan R Littman; Nathaniel R Landau
Identification of a major co-receptor for primary isolates of HIV-1.
Nature 1996;381(6584):661-6.
1996: C D Weiss; Susan W Barnett; N Cacalano; Nigel Killeen; Dan R Littman; Judith M White
Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay.
AIDS (London, England) 1996;10(3):241-6.
1996: Owen Williams; Y Tanaka; Mark Bix; M Murdjeva; Dan R Littman; Dimitris Kioussis
Inhibition of thymocyte negative selection by T cell receptor antagonist peptides.
European journal of immunology 1996;26(3):532-8.
1996: Nigel Killeen; Dan R Littman
The regulation and function of the CD4 coreceptor during T lymphocyte development.
Current topics in microbiology and immunology 1996;205():89-106.
1996: Dan R Littman
The CD4 molecule. Roles in T lymphocytes and in HIV disease. Introduction.
Current topics in microbiology and immunology 1996;205():v-x.
1995: X C Liao; Dan R Littman
Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.
Immunity 1995;3(6):757-69.
1995: C B Davis; Dan R Littman
Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression.
International immunology 1995;7(12):1977-86.
1995: M E Crooks; Dan R Littman; R H Carter; D T Fearon; Arthur Weiss; P H Stein
CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.
Molecular and cellular biology 1995;15(12):6820-8.
1995: M Benkirane; Heidy Schmid-Antomarchi; Dan R Littman; M Hirn; Bernard Rossi; Christian Devaux
The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4.
Journal of virology 1995;69(11):6904-10.
1995: Hana Golding; Dimiter S Dimitrov; Jody Manischewitz; Christopher C Broder; J Robinson; S Fabian; Dan R Littman; Cheryl K Lapham
Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.
Journal of virology 1995;69(10):6140-8.
1995: H Xu; Dan R Littman
The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation.
Annals of the New York Academy of Sciences 1995;766():99-116.
1995: Nigel Killeen; Dan R Littman
The function of the CD4 coreceptor in the development of T cells.
International reviews of immunology 1995;13(1):15-27.
1994: K Chu; Dan R Littman
Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction.
The Journal of biological chemistry 1994;269(39):24095-101.
1994: Dan R Littman
Immunodeficiency viruses. Not enough sans Nef.
Current biology : CB 1994;4(7):618-20.
1994: M E Crooks; Dan R Littman
Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.
Immunity 1994;1(4):277-85.
1994: S Sawada; J D Scarborough; Nigel Killeen; Dan R Littman
A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development.
Cell 1994;77(6):917-29.
1994: Thiruchandurai V Rajan; F K Nelson; N Killeen; L D Shultz; J A Yates; J M Bailis; Dan R Littman; Dale L Greiner
CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Experimental parasitology 1994;78(4):352-60.
1994: C B Davis; Dan R Littman
Thymocyte lineage commitment: is it instructed or stochastic?
Current opinion in immunology 1994;6(2):266-72.
1994: Nigel Killeen; Dan R Littman
Lymphocyte development in genetically manipulated mice.
Therapeutic immunology 1994;1(2):123-33.
1994: Albert Bendelac; N Killeen; Dan R Littman; Ronald H Schwartz
A subset of CD4+ thymocytes selected by MHC class I molecules.
Science (New York, N.Y.) 1994;263(5154):1774-8.
1994: Arthur Weiss; Dan R Littman
Signal transduction by lymphocyte antigen receptors.
Cell 1994;76(2):263-74.
1994: Dan R Littman; C B Davis; Nigel Killeen; H Xu
Signal transduction during T cell development.
Advances in experimental medicine and biology 1994;365():63-71.
1993: Claire F Evans; G F Rall; N Killeen; Dan R Littman; Michael B A Oldstone
CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6259-64.
1993: Hana Golding; Robert Blumenthal; Jody Manischewitz; Dan R Littman; Dimiter S Dimitrov
Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time.
Journal of virology 1993;67(11):6469-75.
1993: Nigel Killeen; C B Davis; K Chu; M E Crooks; S Sawada; J D Scarborough; K A Boyd; S G Stuart; H Xu; Dan R Littman
CD4 function in thymocyte differentiation and T cell activation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):25-34.
1993: Richard M Locksley; Steven L Reiner; F Hatam; Dan R Littman; Nigel Killeen
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
Science (New York, N.Y.) 1993;261(5127):1448-51.
1993: S Sawada; Dan R Littman
A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.
Molecular and cellular biology 1993;13(9):5620-8.
1993: H Xu; Dan R Littman
A kinase-independent function of Lck in potentiating antigen-specific T cell activation.
Cell 1993;74(4):633-43.
1993: Nigel Killeen; Dan R Littman
Helper T-cell development in the absence of CD4-p56lck association.
Nature 1993;364(6439):729-32.
1993: K Zingler; Dan R Littman
Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein increases env incorporation into particles and fusogenicity and infectivity.
Journal of virology 1993;67(5):2824-31.
1993: C B Davis; Nigel Killeen; M E Crooks; D Raulet; Dan R Littman
Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.
Cell 1993;73(2):237-47.
1993: Nigel Killeen; S Sawada; Dan R Littman
Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.
The EMBO journal 1993;12(4):1547-53.
1992: Nigel Killeen; S G Stuart; Dan R Littman
Development and function of T cells in mice with a disrupted CD2 gene.
The EMBO journal 1992;11(12):4329-36.
1992: N R Landau; Dan R Littman
Packaging system for rapid production of murine leukemia virus vectors with variable tropism.
Journal of virology 1992;66(8):5110-3.
1992: Nigel Killeen; A Moriarty; Hung-Sia Teh; Dan R Littman
Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.
The Journal of experimental medicine 1992;176(1):89-97.
1992: A Pelchen-Matthews; I Boulet; Dan R Littman; Remi Fagard; M Marsh
The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits.
The Journal of cell biology 1992;117(2):279-90.
1992: Nicolai S C van Oers; A M Garvin; C B Davis; Katherine Forbush; Douglas A Carlow; Dan R Littman; Roger M Perlmutter; Hung-Sia Teh
Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck.
European journal of immunology 1992;22(3):735-43.
1992: K A Page; S M Stearns; Dan R Littman
Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity.
Journal of virology 1992;66(1):524-33.
1992: Nicolai S C van Oers; A M Garvin; M P Cooke; C B Davis; Dan R Littman; Roger M Perlmutter; Hung-Sia Teh
Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development.
Advances in experimental medicine and biology 1992;323():89-99.
1991: S Sawada; Dan R Littman
Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.
Molecular and cellular biology 1991;11(11):5506-15.
1991: Michael A Teitell; matthew mescher; C A Olson; Dan R Littman; Mitchell Kronenberg
The thymus leukemia antigen binds human and mouse CD8.
The Journal of experimental medicine 1991;174(5):1131-8.
1991: L Poulin; L A Evans; S B Tang; A Barboza; H Legg; Dan R Littman; Jay A Levy
Several CD4 domains can play a role in human immunodeficiency virus infection in cells.
Journal of virology 1991;65(9):4893-901.
1991: J C Carel; V M Holers; W L Chick; Dan R Littman; P E Lacy
Expression of functional human Epstein-Barr virus/C3d receptor ([CR2] CD21) on insulinoma cell line. Induction of tumor rejection but not diabetes in syngeneic rats.
Diabetes 1991;40(7):809-14.
1991: A J Muller; J C Young; Ann Marie Pendergast; M Pondel; N R Landau; Dan R Littman; Owen N Witte
BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.
Molecular and cellular biology 1991;11(4):1785-92.
1991: N Glaichenhaus; Nilabh Shastri; Dan R Littman; J M Turner
Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells.
Cell 1991;64(3):511-20.
1991: Hung-Sia Teh; A M Garvin; Katherine Forbush; Douglas A Carlow; C B Davis; Dan R Littman; Roger M Perlmutter
Participation of CD4 coreceptor molecules in T-cell repertoire selection.
Nature 1991;349(6306):241-3.
1991: N R Landau; K A Page; Dan R Littman
Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range.
Journal of virology 1991;65(1):162-9.
1991: Maria Jasin; K A Page; Dan R Littman
Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides.
Journal of virology 1991;65(1):440-4.
1990: K A Page; N R Landau; Dan R Littman
Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity.
Journal of virology 1990;64(11):5270-6.
1990: Russell D Salter; R J Benjamin; P K Wesley; S E Buxton; T P Garrett; Carol Clayberger; Alan Krensky; A M Norment; Dan R Littman; Peter Parham
A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.
Nature 1990;345(6270):41-6.
1990: Michael H Brodsky; M Warton; Richard Myers; Dan R Littman
Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):3078-86.
1990: J M Turner; Michael H Brodsky; B A Irving; S D Levin; Roger M Perlmutter; Dan R Littman
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.
Cell 1990;60(5):755-65.
1989: Dan R Littman
Role of cell-to-cell interactions in T lymphocyte development and activation.
Current opinion in cell biology 1989;1(5):920-8.
1989: A M Norment; N Lonberg; Elizabeth Lacy; Dan R Littman
Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3312-9.
1989: Russell D Salter; A M Norment; B P Chen; Carol Clayberger; Alan Krensky; Dan R Littman; Peter Parham
Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.
Nature 1989;338(6213):345-7.
1989: Judith M White; Dan R Littman
Viral receptors of the immunoglobulin superfamily.
Cell 1989;56(5):725-8.
1989: Peter Parham; R J Benjamin; B P Chen; Carol Clayberger; P D Ennis; Alan Krensky; D A Lawlor; Dan R Littman; A M Norment; Harry T Orr
Diversity of class I HLA molecules: functional and evolutionary interactions with T cells.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():529-43.
1988: Dan R Littman; P J Maddon; Richard Axel
Corrected CD4 sequence.
Cell 1988;55(4):541.
1988: A M Norment; Russell D Salter; Peter Parham; V H Engelhard; Dan R Littman
Cell-cell adhesion mediated by CD8 and MHC class I molecules.
Nature 1988;336(6194):79-81.
1988: A M Norment; Dan R Littman
A second subunit of CD8 is expressed in human T cells.
The EMBO journal 1988;7(11):3433-9.
1988: E Kaldjian; S A McCarthy; Susan O Sharrow; Dan R Littman; Richard D Klausner; Alfred Singer
Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(12):2801-6.
1988: P Bedinger; A Moriarty; R C von Borstel; N J Donovan; K S Steimer; Dan R Littman
Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4.
Nature 1988;334(6178):162-5.
1988: N R Landau; M Warton; Dan R Littman
The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4.
Nature 1988;334(6178):159-62.
1988: N Lonberg; S N Gettner; Elizabeth Lacy; Dan R Littman
Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein.
Molecular and cellular biology 1988;8(5):2224-8.
1988: C B Newgard; Dan R Littman; C van Genderen; M Smith; Robert J Fletterick
Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes.
The Journal of biological chemistry 1988;263(8):3850-7.
1988: M Subar; P Giuseppe Pelicci; A Neri; P Allavena; Dan R Littman; Daniel M Knowles; R Dalla-Favera
Patterns of T cell receptor gamma gene rearrangement and expression in B and T lymphoid malignancies.
Leukemia 1988;2(1):19-26.
1987: E Y Loh; Lewis L Lanier; Christoph W Turck; Dan R Littman; Mark M Davis; Yueh-hsiu Chien; A Weiss
Identification and sequence of a fourth human T cell antigen receptor chain.
Nature 1987;330(6148):569-72.
1987: P G Pelicci; M Subar; A Weiss; R Dalla-Favera; Dan R Littman
Molecular diversity of the human T-gamma constant region genes.
Science (New York, N.Y.) 1987;237(4818):1051-5.
1987: Y Hashimoto; K Yui; Dan R Littman; M I Greene
T-cell receptor genes in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5883-7.
1987: Lewis L Lanier; N A Federspiel; J J Ruitenberg; Joseph H Phillips; J P Allison; Dan R Littman; A Weiss
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
The Journal of experimental medicine 1987;165(4):1076-94.
1987: Dan R Littman; M Newton; D Crommie; S L Ang; J G Seidman; S N Gettner; A Weiss
Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism.
Nature 1987;326(6108):85-8.
1987: Dan R Littman; S N Gettner
Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene.
Nature 1987;325(6103):453-5.
1987: Dan R Littman
The structure of the CD4 and CD8 genes.
Annual review of immunology 1987;5():561-84.
1987: Dan R Littman
Structure and potential function of the murine L3T4 molecule.
Annales de l'Institut Pasteur. Immunology 1987;138(1):147-50.
1987: P G Pelicci; A Neri; Daniel M Knowles; Dan R Littman; R Dalla-Favera; M Subar
Arrangements and rearrangements of the human T-cell receptor gamma gene.
Annals of the New York Academy of Sciences 1987;511():232-45.
1986: M Isobe; K Huebner; P J Maddon; Dan R Littman; Richard Axel; C M Croce
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4399-402.
1986: J S McDougal; Paul J Maddon; A G Dalgleish; Paul R Clapham; Dan R Littman; M Godfrey; D E Maddon; Leonard Chess; R A Weiss; Richard Axel
The T4 glycoprotein is a cell-surface receptor for the AIDS virus.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():703-11.
1985: Paul J Maddon; Dan R Littman; M Godfrey; D E Maddon; Leonard Chess; Richard Axel
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
Cell 1985;42(1):93-104.
1985: Dan R Littman; Y Thomas; Paul J Maddon; Leonard Chess; Richard Axel
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.
Cell 1985;40(2):237-46.
1979: S E Cullen; C S Kindle; Dan R Littman
Structural comparison of murine Ia antigens determined by the I-A and I-E subregions.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(3):855-9.
1979: Dan R Littman; S E Cullen; B D Schwartz
Insertion of Ia and H-2 alloantigens into model membranes.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):902-6.