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Chunyan Liu

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Mariana Puntel; Alireza Salem; Nathan Vanderveen; Ghulam Muhammad A K M; Ashley Appelhans; Catherine Farrokhi; Sukhpreet Kaur; Kyle R Kelson; Sean Kennedy; Johnny Krasinkiewicz; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Christopher Paran; Robert N Pechnick; Maria G Castro
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Yohei Mineharu; Mariana Puntel; Weidong Xiong; Kader Yagiz; A K M Ghulam Muhammad; Michael A Curran; Adrina Kocharian; Kurt M Kroeger; Eva Levy; Chunyan Liu; Pedro R Lowenstein; Claudia Lugo; James P Allison; Marianela Candolfi; Maria G Castro
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
A K M Ghulam Muhammad; Catherine Farrokhi; Kyle R Kelson; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Robert N Pechnick; Mariana Puntel; Alireza Salem; Weidong Xiong; Maria G Castro
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.

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All Publications

2013: Mariana Puntel; Alireza Salem; Nathan Vanderveen; Ghulam Muhammad A K M; Ashley Appelhans; Catherine Farrokhi; Sukhpreet Kaur; Kyle R Kelson; Sean Kennedy; Johnny Krasinkiewicz; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Christopher Paran; Robert N Pechnick; Maria G Castro
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Toxicology and applied pharmacology 2013;268(3):318-30.
2012: Yohei Mineharu; Mariana Puntel; Weidong Xiong; Kader Yagiz; A K M Ghulam Muhammad; Michael A Curran; Adrina Kocharian; Kurt M Kroeger; Eva Levy; Chunyan Liu; Pedro R Lowenstein; Claudia Lugo; James P Allison; Marianela Candolfi; Maria G Castro
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2012;9(4):827-43.
2012: A K M Ghulam Muhammad; Catherine Farrokhi; Kyle R Kelson; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Robert N Pechnick; Mariana Puntel; Alireza Salem; Weidong Xiong; Maria G Castro
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Human gene therapy methods 2012;23(4):271-84.
2012: Jeffrey M Zirger; Rameen Moridzadeh; Mariana Puntel; Mia Wibowo; Carlos Barcia; Josee Bergeron; Niyati Bondale; Maria G Castro; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(4):808-19.
2011: Marianela Candolfi; Gabrielle E Alzadeh; Hikmat Assi; James F Curtin; Robert Dunn; David Foulad; Naomi Keech; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Gislaine Martins; Mariana Puntel; Sofia Salehi; Nicholas R Sanderson; Mia K Wibowo; Kader Yagiz; A K M G Muhammad; Maria G Castro
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Neoplasia (New York, N.Y.) 2011;13(10):947-60.
2011: Marianela Candolfi; Hikmat Assi; Gregory J Baker; David Foulad; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Yohei Mineharu; Akm Ghulam Muhammad; Mariana Puntel; Mia Wibowo; Weidong Xiong; Kader Yagiz; Maria G Castro
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Anti-cancer agents in medicinal chemistry 2011;11(8):729-38.
2011: Gwendalyn D King; Kurt M Kroeger; Daniel Larocque; Chunyan Liu; Maria G Castro; Kyle R Kelson; A K M Ghulam Muhammad; Nicholas S R Sanderson; Weidong Xiong; Pedro R Lowenstein
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1793-801.
2011: Mariana Puntel; Nicholas S R Sanderson; Mia Wibowo; Robert Barrett; Niyati Bondale; Maria G Castro; Sean Kennedy; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein
Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain.
PloS one 2011;6(8):e23523.
2010: Marianela Candolfi; Weidong Xiong; Kader Yagiz; Chunyan Liu; A K M G Muhammad; Mariana Puntel; David Foulad; Ali Zadmehr; Gabrielle E Ahlzadeh; Kurt M Kroeger; Matthew Tesarfreund; Sharon Lee; Waldemar Debinski; Dhruv Sareen; Clive Svendsen; Ronald Rodriguez; Pedro R Lowenstein; Maria G Castro
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20021-6.
2010: A K M G Muhammad; Mariana Puntel; Marianela Candolfi; A Salem; K Yagiz; C Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; K Lawrence; N S Bondale; J Lerner; G J Baker; D Foulad; Robert N Pechnick; Donna Palmer; P Ng; Pedro R Lowenstein; Maria G Castro
Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.
Clinical pharmacology and therapeutics 2010;88(2):204-13.
2010: Mariana Puntel; A K M G Muhammad; Marianela Candolfi; Alireza Salem; Kader Yagiz; Catherine Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; Niyati S Bondale; Jonathan Lerner; Robert N Pechnick; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
Journal of virology 2010;84(12):6007-17.
2010: Weidong Xiong; Marianela Candolfi; Chunyan Liu; A K M Ghulam Muhammad; Kader Yagiz; Mariana Puntel; Peter F Moore; Julie Avalos; John D Young; Dorothy Khan; Randy Donelson; G Elizabeth Pluhar; John R Ohlfest; Kolja Wawrowsky; Pedro R Lowenstein; Maria G Castro
Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.
PloS one 2010;5(6):e11074.
2009: Marianela Candolfi; Kader Yagiz; David Foulad; Gabrielle E Alzadeh; Matthew Tesarfreund; A K M Ghulam Muhammad; Mariana Puntel; Kurt M Kroeger; Chunyan Liu; Sharon Lee; James F Curtin; Gwendalyn D King; Jonathan Lerner; Katsuaki Sato; Yohei Mineharu; Weidong Xiong; Pedro R Lowenstein; Maria G Castro
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4401-14.
2009: Mariana Puntel; R J Barrett; Sonali Mondkar; V Saxena; Kurt M Kroeger; A K M Muhammad; Chunyan Liu; N Bondale; Sandra A Sciascia; Weidong Xiong; Y Shi; A Salem; A Zadmehr; P Huynh; Donna Palmer; P Ng; Maria G Castro; Pedro R Lowenstein
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Journal of virology 2009;83(4):2004-10.
2009: James F Curtin; Naiyou Liu; Marianela Candolfi; Weidong Xiong; Hikmat Assi; Kader Yagiz; Matthew R Edwards; Kathrin S Michelsen; Kurt M Kroeger; Chunyan Liu; A K M Ghulam Muhammad; Mary C Clark; Moshe Arditi; Begonya Comin-Anduix; Antoni Ribas; Pedro R Lowenstein; Maria G Castro
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS medicine 2009;6(1):e10.
2008: Thomas Southgate; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Maria G Castro
Gene transfer into neural cells in vitro using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2008;Chapter 4():Unit 4.23.
2008: Gwendalyn D King; Kurt M Kroeger; Catherine J Bresee; Marianela Candolfi; Chunyan Liu; Charlene M Manalo; A K M Ghulam Muhammad; Robert N Pechnick; Pedro R Lowenstein; Maria G Castro
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):682-90.
2008: Carlos Barcia; Kolja Wawrowsky; Robert J Barrett; Chunyan Liu; Maria G Castro; Pedro R Lowenstein
In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1344-52.
2008: Weidong Xiong; Marianela Candolfi; Kurt M Kroeger; Mariana Puntel; Sonali Mondkar; Daniel Larocque; Chunyan Liu; James F Curtin; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):343-51.
2008: Gwendalyn D King; A K M Ghulam Muhammad; James F Curtin; Carlos Barcia; Mariana Puntel; Chunyan Liu; Sarah B Honig; Marianela Candolfi; Sonali Mondkar; Pedro R Lowenstein; Maria G Castro
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
Neuro-oncology 2008;10(1):19-31.
2008: Carlos Barcia; Nicholas S R Sanderson; Robert J Barrett; Kolja Wawrowsky; Kurt M Kroeger; Mariana Puntel; Chunyan Liu; Maria G Castro; Pedro R Lowenstein
T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.
PloS one 2008;3(8):e2977.
2008: James F Curtin; Marianela Candolfi; Tamer M Fakhouri; Chunyan Liu; Anderson Alden; Matthew Edwards; Pedro R Lowenstein; Maria G Castro
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials.
PloS one 2008;3(4):e1983.
2007: Carlos Barcia; Maximiliano Jimenez-Dalmaroni; Kurt M Kroeger; Mariana Puntel; Alison J Rapaport; Daniel Larocque; Gwendalyn D King; Stephen A Johnson; Chunyan Liu; Weidong Xiong; Marianela Candolfi; Sonali Mondkar; Philip Ng; Donna Palmer; Maria G Castro; Pedro R Lowenstein
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2154-63.
2007: Seunguk Oh; Rick Odland; Scott R Wilson; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Maria G Castro; Walter A Hall; John R Ohlfest
Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.
Journal of neurosurgery 2007;107(3):568-77.
2007: Seunguk Oh; G Elizabeth Pluhar; Elizabeth A McNeil; Kurt M Kroeger; Chunyan Liu; Maria G Castro; Pedro R Lowenstein; Andrew Freese; John R Ohlfest
Efficacy of nonviral gene transfer in the canine brain.
Journal of neurosurgery 2007;107(1):136-44.
2007: Marianela Candolfi; G Elizabeth Pluhar; Kurt M Kroeger; Mariana Puntel; James Curtin; Carlos Barcia; A K M Ghulam Muhammad; Weidong Xiong; Chunyan Liu; Sonali Mondkar; William Kuoy; Terry Kang; Elizabeth A McNeil; Andrew Freese; John R Ohlfest; Peter F Moore; Donna Palmer; Phillip Ng; John D Young; Pedro R Lowenstein; Maria G Castro
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Neuro-oncology 2007;9(3):245-58.
2006: Carlos Barcia; Christian Gerdes; Wei-Dong Xiong; Clare E Thomas; Chunyan Liu; Kurt M Kroeger; Maria G Castro; Pedro R Lowenstein
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.
Neuron glia biology 2006;2(4):309-22.
2006: Carlos Barcia; Clare E Thomas; James F Curtin; Gwendalyn D King; Kolja Wawrowsky; Marianela Candolfi; Wei-Dong Xiong; Chunyan Liu; Kurt M Kroeger; Olivier Boyer; Jerzy W Kupiec-Weglinski; David Klatzmann; Maria G Castro; Pedro R Lowenstein
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain.
The Journal of experimental medicine 2006;203(9):2095-107.
2006: Marianela Candolfi; James F Curtin; Wei-Dong Xiong; Kurt M Kroeger; Chunyan Liu; Altan Rentsendorj; Hasmik Agadjanian; Lali K Medina-Kauwe; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(3):371-81.
2006: Jeffrey M Zirger; Carlos Barcia; Chunyan Liu; Mariana Puntel; Ngan Mitchell; Iain Campbell; Maria Castro; Pedro R Lowenstein
Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain.
Journal of virology 2006;80(11):5655-9.
2006: Mariana Puntel; James F Curtin; Jeffrey M Zirger; A K M Muhammad; Weidong Xiong; Chunyan Liu; Jinwei Hu; Kurt M Kroeger; P Czer; Sandra A Sciascia; Sonali Mondkar; Pedro R Lowenstein; Maria G Castro
Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.
Human gene therapy 2006;17(5):531-44.
2006: James F Curtin; Gwendalyn D King; Carlos Barcia; Chunyan Liu; FX Hubert; Carole Guillonneau; Régis Josien; Ignacio Anegon; Pedro R Lowenstein; Maria G Castro
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3566-77.
2006: Jeffrey M Zirger; Chunyan Liu; Carlos Barcia; Maria G Castro; Pedro R Lowenstein
Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors.
Viral immunology 2006;19(3):508-17.
2006: Weidong Xiong; Shyam Goverdhana; Sandra A Sciascia; Marianela Candolfi; Jeffrey M Zirger; Carlos Barcia; James F Curtin; Gwendalyn D King; Gabriela Jaita; Chunyan Liu; Kurt M Kroeger; Hasmik Agadjanian; Lali K Medina-Kauwe; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Journal of virology 2006;80(1):27-37.
2005: Sumia Ali; Gwendalyn D King; James F Curtin; Marianela Candolfi; Weidong Xiong; Chunyan Liu; Mariana Puntel; Queng Cheng; Jesus Prieto; Antoni Ribas; Jerzy W Kupiec-Weglinski; Nico van Rooijen; Hans Lassmann; Pedro R Lowenstein; Maria G Castro
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Cancer research 2005;65(16):7194-204.
2004: Sumia Ali; James F Curtin; Jeffrey M Zirger; Weidong Xiong; Gwendalyn D King; Carlos Barcia; Chunyan Liu; Mariana Puntel; Shyam Goverdhana; Pedro R Lowenstein; Maria G Castro
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1071-84.