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Hong Liu

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TOP 3
Wei Yang; Liliang Huang; Hong Liu; Wei Wang; Hao Li
Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines.
Xun Ji; Hualiang Jiang; Jinfang Wang; Linxiang Zhao; Yu Zhou; Hong Liu
Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones.
Dengyou Zhang; Wei Zhu; Cheng Luo; Xia Peng; Jing Ai; Xianjie Chen; Meiyu Geng; YinChun Ji; Hualiang Jiang; Zhongjie Liang; Hong Liu
Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.

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All Publications

2013: Wei Yang; Liliang Huang; Hong Liu; Wei Wang; Hao Li
Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines.
Chemical communications (Cambridge, England) 2013;49(41):4667-9.
2013: Xun Ji; Hualiang Jiang; Jinfang Wang; Linxiang Zhao; Yu Zhou; Hong Liu
Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones.
The Journal of organic chemistry 2013;78(9):4312-8.
2013: Dengyou Zhang; Wei Zhu; Cheng Luo; Xia Peng; Jing Ai; Xianjie Chen; Meiyu Geng; YinChun Ji; Hualiang Jiang; Zhongjie Liang; Hong Liu
Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(8):2408-13.
2013: Lei Zhang; Fei Zhao; Mingyue Zheng; Yun Zhai; Hong Liu
Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating.
Chemical communications (Cambridge, England) 2013;49(28):2894-6.
2013: Jinfang Wang; Lei Zhang; Yu Zhou; Xianjie Chen; Zeng Li; Hong Liu
Asymmetric Michael addition of N-tert-butanesulfinyl imidate with α,β-unsaturated diesters: scope and application to the synthesis of indanone derivatives.
Organic letters 2013;15(7):1508-11.
2013: Daizong Lin; Hualiang Jiang; Jie Lian; Jiang Wang; Xu Zhang; Shengbin Zhou; Hong Liu
Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles.
Chemical communications (Cambridge, England) 2013;49(25):2575-7.
2013: Haifeng Sun; Huicui Yang; Xuechu Zhen; Shengbin Zhou; Yu Zhou; Liyuan Zhu; Kaixian Chen; Bo Gao; Lin Guo; Hualiang Jiang; Zeng Li; Wangke Qian; Hong Liu
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.
Bioorganic & medicinal chemistry 2013;21(4):856-68.
2013: Enguang Feng; Hualiang Jiang; Jian Li; Xian Liu; Kyoung Tai No; Baik-Lin Seong; Woo-Jin Shin; Wei Tang; Jiang Wang; Deju Ye; Mingyue Zheng; Weiliang Zhu; Xuelian Zhu; Jian-Ping Zuo; Hong Liu
Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
Journal of medicinal chemistry 2013;56(3):671-84.
2013: Jiahui Wu; Niefang Yu; Dengyou Zhang; Fei Zhao; Dongying Chen; Kaixian Chen; Lei Chen; Xiaoyan Chen; Hualiang Jiang; Jianneng Li; Hong Liu; Chengqing Ning; Jianling Wang; Dongxiang Liu
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.
Journal of medicinal chemistry 2013;56(3):761-80.
2013: Xiao Ding; Hualiang Jiang; Daizong Lin; Xiaomin Luo; Li Lv; Vadim A Soloshonok; Hengshuai Wang; Jiang Wang; Sinan Wang; Yu Zhou; José Luis Aceña; Hong Liu
Synthesis of polysubstituted β-amino cyclohexane carboxylic acids via Diels-Alder reaction using Ni(II)-complex stabilized β-alanine derived dienes.
Amino acids 2013;44(2):791-6.
2013: Lei Zhang; Mingbo Su; Jiang Wang; Xun Ji; Jingya Li; Jia Li; Zeng Li; Hong Liu
Design, synthesis, structure-activity relationships, and docking studies of 1-(γ-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors.
Chemical biology & drug design 2013;81(2):198-207.
2012: Lei Zhang; Qingzhang Zhu; Jun Liu; Xiaomin Luo; Xiaojie Chen; Hualiang Jiang; Ying Leng; Hong Liu
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase.
European journal of medicinal chemistry 2012;58():624-39.
2012: Di-Liang Guo; Zeng Li; Kai-Xian Chen; Rui-Rui Wang; Jin-Yi Xu; Xing-Jie Zhang; Yong-Tang Zheng; Yu Zhou; Hong Liu
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity.
Bioorganic & medicinal chemistry letters 2012;22(23):7114-8.
2012: Xiaodong Zhang; Mingbo Su; Jiang Wang; Jingya Li; Jia Li; Zeng Li; Hong Liu
Discovering novel α-aminoacyl-containing proline derivatives with potent and selective inhibitory activity against dipeptidyl peptidase IV: design, synthesis, biological evaluation, and molecular modeling.
Chemical biology & drug design 2012;80(6):843-52.
2012: Baoen Chen; Kai Chen; Shouze Gong; Xiaotian Huang; Guifang Jia; Hualiang Jiang; Haiyan Li; Hong Liu; Cheng Luo; Shuying Peng; Meining Wang; Yiming Yang; Fei Ye; Jinya Yin; Lu Yu; Ao Zhang; Haiyan Zhang; Jiwen Zhang; Ruihan Zhang; Xueju Zhang; Cai-Guang Yang
Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.
Journal of the American Chemical Society 2012;134(43):17963-71.
2012: Xiangqian Kong; Zeng Li; Zhongjie Liang; Hong Liu; Shien Liu; Junyan Lu; Ronen Marmorstein; Jie Qin; Geena Rajan; Linjiang Tong; Adina Vultur; Mingyue Zheng; Weiliang Zhu; Enguang Feng; Meenhard Herlyn; Hualiang Jiang; Cheng Luo
Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.
Organic & biomolecular chemistry 2012;10(36):7402-17.
2012: Dengyou Zhang; Cheng Luo; Xia Peng; Jing Ai; Meiyu Geng; Yinchun Ji; Hualiang Jiang; Chunpu Li; Zhongjie Liang; Hong Liu
Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors.
Bioorganic & medicinal chemistry 2012;20(17):5169-80.
2012: Enguang Feng; Rolf Hilgenfeld; Hualiang Jiang; Jian Li; Jinfang Wang; Deju Ye; Dengyou Zhang; Fei Zhao; Mingyue Zheng; Hong Liu
Recent advances in neuraminidase inhibitor development as anti-influenza drugs.
ChemMedChem 2012;7(9):1527-36.
2012: Deju Ye; Weiliang Zhu; Jian-Ping Zuo; Kyoung Tai No; Enguang Feng; Pei-Lan He; Hualiang Jiang; Hanjo Kim; Jian Li; Ning Li; Ky-Youb Nam; Baik-Lin Seong; Woo-Jin Shin; Wei Tang; Hong Liu
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.
European journal of medicinal chemistry 2012;54():764-70.
2012: Huina Wang; Wei Wang; Wei Yang; Hong Liu; Hao Li
FeCl3 promoted highly regioselective [3 + 2] cycloaddition of dimethyl 2-vinyl and aryl cyclopropane-1,1-dicarboxylates with aryl isothiocyanates.
Organic & biomolecular chemistry 2012;10(26):5032-5.
2012: Ping Li; Hong Liu; Chao-ying Ma; Hai-feng Sun; Ping-zheng Zhou; Guo-Yuan Hu; Hua-Liang Jiang; Min Li; Zhao-Bing Gao
Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels.
Acta pharmacologica Sinica 2012;33(6):728-36.
2012: Jiang Wang; Xun Ji; Hualiang Jiang; Jianmei Shi; Haifeng Sun; Hong Liu
Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of β-substituted α,γ-diaminobutyric acid derivatives in water.
Amino acids 2012;42(5):1685-94.
2012: Jinwei Wu; Xiaodong Zhang; Weiliang Zhu; Hualiang Jiang; Hong Liu; Peng Sun; Heyao Wang
Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis.
Journal of cellular biochemistry 2012;113(4):1152-8.
2012: Dengyou Zhang; Lei Zhang; Yu Zhou; Haifeng Sun; Kaixian Chen; Hualiang Jiang; Chunpu Li; Hong Liu
An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6].
Chemical communications (Cambridge, England) 2012;48(23):2909-11.
2011: Fei Wang; Heyao Wang; Jian Zhang; Mingyue Zheng; Weiliang Zhu; Dongxiang Liu; Hong Liu; Cheng Luo; Xiaomin Luo; Hualiang Jiang
Computational screening for active compounds targeting protein sequences: methodology and experimental validation.
Journal of chemical information and modeling 2011;51(11):2821-8.
2011: Jin-gui Ma; Xian-liang Xin; Si-meng Chen; Yi Chen; Jian Ding; He Huang; Li-Ping Lin; Hong Liu; Ling-Hua Meng
PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.
Breast cancer research and treatment 2011;130(1):85-96.
2011: Daizong Lin; Xiao Ding; Hualiang Jiang; Li Lv; Jiang Wang; Hong Liu
Preparation of α-alkyl-β-amino acids via β-alanine Ni(II) complex.
The Journal of organic chemistry 2011;76(16):6649-56.
2011: Jiang Wang; Shengbin Zhou; Xiao Ding; Hualiang Jiang; Daizong Lin; Hong Liu
Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetric Michael addition of a chiral equivalent of nucleophilic glycine and sulfonylindoles.
Chemical communications (Cambridge, England) 2011;47(29):8355-7.
2011: Zhongjie Liang; Dengyou Zhang; Jing Ai; Limin Chen; Hengshuai Wang; Xiangqian Kong; Mingyue Zheng; Hong Liu; Cheng Luo; Meiyu Geng; Hualiang Jiang; Kaixian Chen
Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.
Bioorganic & medicinal chemistry letters 2011;21(12):3749-54.
2011: Diliang Guo; Tao Chen; Deju Ye; Jinyi Xu; Hualiang Jiang; Kaixian Chen; Hui Wang; Hong Liu
Cell-permeable iminocoumarine-based fluorescent dyes for mitochondria.
Organic letters 2011;13(11):2884-7.
2011: Sinan Wang; Lei Zhang; Xiao Ding; Yu Zhou; Jinfang Wang; Hualiang Jiang; Hong Liu
Synthesis of 2-phenylnaphthalenes through gold-catalyzed dimerization via a highly selective carbon nucleophile pathway.
The Journal of organic chemistry 2011;76(11):4514-21.
2011: Zhongjie Liang; Liying Zhang; Lianchun Li; Jun Liu; Hongling Li; Luyong Zhang; Limin Chen; Keguang Cheng; Mingyue Zheng; Xiaoan Wen; Pu Zhang; Jia Hao; Yanchun Gong; Xia Zhang; Xiaoyun Zhu; Jun Chen; Hong Liu; Hualiang Jiang; Cheng Luo; Hongbin Sun
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry 2011;46(6):2011-21.
2011: Yu Zhou; Jian Li; Xun Ji; Wei Zhou; Xu Zhang; Wangke Qian; Hualiang Jiang; Hong Liu
Silver- and gold-mediated domino transformation: a strategy for synthesizing benzo[e]indolo[1,2-a]pyrrolo/pyrido[2,1-c][1,4]diazepine-3,9-diones.
The Journal of organic chemistry 2011;76(5):1239-49.
2011: Jiang Wang; Daizong Lin; Shengbin Zhou; Xiao Ding; Vadim A Soloshonok; Hong Liu
Asymmetric synthesis of sterically and electronically demanding linear ω-trifluoromethyl containing amino acids via alkylation of chiral equivalents of nucleophilic glycine and alanine.
The Journal of organic chemistry 2011;76(2):684-7.
2011: Jiang Wang; Lei Zhang; Kaixian Chen; Hualiang Jiang; Hong Liu
Application of nickel(II) complexes to the efficient synthesis of α- or β-amino acids.
Chimia 2011;65(12):919-24.
2011: Zhongjie Liang; Hong Liu; Cheng Luo; Xu Shen; Yuanyuan Wang; Mingyue Zheng; Kaixian Chen; Limin Chen; Cai Guang-Yang; Yao Hong; Xiangqian Kong; Lefu Lan; Keqin Kathy Li; Lianchun Li; Hualiang Jiang
Molecular basis of NDM-1, a new antibiotic resistance determinant.
PloS one 2011;6(8):e23606.
2011: S Lu; Hong Liu; Jerry M Farley
Macrolide antibiotics inhibit mucus secretion and calcium entry in Swine airway submucosal mucous gland cells.
The Journal of pharmacology and experimental therapeutics 2011;336(1):178-87.
2010: Fang Liu; Xiao Ding; Lei Zhang; Yu Zhou; Linxiang Zhao; Hualiang Jiang; Hong Liu
Silver- and gold-mediated intramolecular cyclization to substituted tetracyclic isoquinolizinium hexafluorostilbates.
The Journal of organic chemistry 2010;75(17):5810-20.
2010: He Huang; Jingui Ma; Jianmei Shi; Linghua Meng; Hualiang Jiang; Jian Ding; Hong Liu
Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase.
Bioorganic & medicinal chemistry 2010;18(13):4615-24.
2010: Lei Zhang; Hong Liu
Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and GL-subunit of glycogen-associated protein phosphatase 1: WO2009127723.
Expert opinion on therapeutic patents 2010;20(7):969-73.
2010: Dengyou Zhang; Deju Ye; Enguang Feng; Jinfang Wang; Jianmei Shi; Hualiang Jiang; Hong Liu
Highly alpha-selective synthesis of sialyl spirohydantoins by regiospecific domino condensation/O-->N acyl migration/N-sialylation of carbodiimides with peracetylated sialic acid.
The Journal of organic chemistry 2010;75(11):3552-7.
2010: Lei Zhang; Deju Ye; Yu Zhou; Guannan Liu; Enguang Feng; Hualiang Jiang; Hong Liu
Regioselective synthesis of 3-benzazepinones and unexpected 5-bromo-3-benzazepinones.
The Journal of organic chemistry 2010;75(11):3671-7.
2010: Enguang Feng; Yu Zhou; Dengyou Zhang; Lei Zhang; Haifeng Sun; Hualiang Jiang; Hong Liu
Gold(I)-catalyzed tandem transformation: a simple approach for the synthesis of pyrrolo/pyrido[2,1-a][1,3]benzoxazinones and pyrrolo/pyrido[2,1-a]quinazolinones.
The Journal of organic chemistry 2010;75(10):3274-82.
2010: Yu Feng; Xiao Ding; Tao Chen; Lili Chen; Fang Liu; Xu Jia; Xiaomin Luo; Xu Shen; Kaixian Chen; Hualiang Jiang; Hui Wang; Hong Liu; Dongxiang Liu
Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
Journal of medicinal chemistry 2010;53(9):3465-79.
2010: He Huang; Qin Chen; Xin Ku; Linghua Meng; Liping Lin; Xiang Wang; Caihua Zhu; Yi Wang; Zhi Chen; Ming Li; Hualiang Jiang; Kaixian Chen; Jian Ding; Hong Liu
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Journal of medicinal chemistry 2010;53(8):3048-64.
2010: Deju Ye; Yu Zhang; Fei Wang; Mingfang Zheng; Xu Zhang; Xiaomin Luo; Xu Shen; Hualiang Jiang; Hong Liu
Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.
Bioorganic & medicinal chemistry 2010;18(5):1773-82.
2010: Jiang Wang; Lei Zhang; Hualiang Jiang; Hong Liu
Most efficient routes for the synthesis of alpha,beta-diamino acid-derived compounds.
Current pharmaceutical design 2010;16(10):1252-9.
2009: Lei Zhang; Honglin Li; Qingzhang Zhu; Jun Liu; Ling Chen; Ying Leng; Hualiang Jiang; Hong Liu
Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.
Bioorganic & medicinal chemistry 2009;17(20):7301-12.
2009: He Huang; Hualiang Jiang; Kaixian Chen; Hong Liu
A simple and convenient copper-catalyzed tandem synthesis of quinoline-2-carboxylates at room temperature.
The Journal of organic chemistry 2009;74(15):5476-80.
2009: Xin Ku; He Huang; Hualiang Jiang; Hong Liu
Efficient iron/copper cocatalyzed S-arylations of thiols with aryl halides.
Journal of combinatorial chemistry 2009;11(3):338-40.
2009: Lingyan He; Liang Zhang; Xiaofeng Liu; Xianghua Li; Mingyue Zheng; Honglin Li; Kunqian Yu; Kaixian Chen; Xu Shen; Hualiang Jiang; Hong Liu
Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
Journal of medicinal chemistry 2009;52(8):2465-81.
2008: Hai-hong Li; He Huang; Xiu-hua Zhang; Xiao-Min Luo; Li-Ping Lin; Hua-Liang Jiang; Jian Ding; Kai-xian Chen; Hong Liu
Discovering novel 3-nitroquinolines as a new class of anticancer agents.
Acta pharmacologica Sinica 2008;29(12):1529-38.
2008: Guanghui Deng; Zhiguo Liu; Fei Ye; Xiaomin Luo; Weiliang Zhu; Xu Shen; Hong Liu; Hualiang Jiang
Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.
European journal of medicinal chemistry 2008;43(12):2699-716.
2008: Guanghui Deng; Weihua Li; Jianhua Shen; Hualiang Jiang; Kaixian Chen; Hong Liu
Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry letters 2008;18(20):5497-502.
2008: He Huang; Hong Liu; Hualiang Jiang; Kaixian Chen
Rapid and efficient Pd-catalyzed Sonogashira coupling of aryl chlorides.
The Journal of organic chemistry 2008;73(15):6037-40.
2008: Zhaoguang Li; He Huang; Hongbin Sun; Hualiang Jiang; Hong Liu
Microwave-assisted efficient and convenient synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolines.
Journal of combinatorial chemistry 2008;10(3):484-6.
2008: Shiyu Chen; He Huang; Xuejun Liu; Jingkang Shen; Hualiang Jiang; Hong Liu
Microwave-assisted efficient copper-promoted N-arylation of amines with arylboronic acids.
Journal of combinatorial chemistry 2008;10(3):358-60.
2008: Zhao-Bing Gao; Xue-Qin Chen; Hua-liang Jiang; Hong Liu; Guo-Yuan Hu
Electrophysiological characterization of a novel Kv channel blocker N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ]bis(4-methyl)-benzenesulfonamide found in virtual screening.
Acta pharmacologica Sinica 2008;29(4):405-12.
2007: Guanghui Deng; Jiang Wang; Yu Zhou; Hualiang Jiang; Hong Liu
One-pot, large-scale synthesis of Nickel(II) complexes derived from 2-[N-(alpha-picolyl)amino]benzophenone (PABP) and alpha- or beta-amino acids.
The Journal of organic chemistry 2007;72(23):8932-4.
2007: He Huang; Hong Liu; Kaixian Chen; Hualiang Jiang
Microwave-assisted rapid synthesis of 2,6,9-substituted purines.
Journal of combinatorial chemistry 2007;9(2):197-9.
2007: Ling Sun; Chong S Chen; David J Waxman; Hong Liu; James Halpert; Santosh Kumar
Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
Archives of biochemistry and biophysics 2007;458(2):167-74.
2007: Hong Liu; Zhao-Bing Gao; Zhiyi Yao; Suxin Zheng; Yang Li; Weiliang Zhu; Xiaojian Tan; Xiaomin Luo; Jianhua Shen; Kaixian Chen; Guo-Yuan Hu; Hualiang Jiang
Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay.
Journal of medicinal chemistry 2007;50(1):83-93.
2007: Hai-Hong Li; Xiu-Hua Zheng; Jin-zhi Tan; Li-Li Chen; Hong Liu; Xiao-Min Luo; Xu Shen; Li-Ping Lin; Kai-Xian Chen; Jian Ding; Hua-Liang Jiang
Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives.
Acta pharmacologica Sinica 2007;28(1):140-52.
2006: Santosh Kumar; Ling Sun; Hong Liu; BK Muralidhara; James Halpert
Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.
Protein engineering, design & selection : PEDS 2006;19(12):547-54.
2006: Santosh Kumar; Hong Liu; James Halpert
Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):1958-65.
2006: Cynthia E Hernandez; Santosh Kumar; Hong Liu; James Halpert
Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.
Archives of biochemistry and biophysics 2006;455(1):61-7.
2006: Jian Li; Mingyue Zheng; Wei Tang; Pei-Lan He; Weiliang Zhu; Tianxian Li; Jian-Ping Zuo; Hong Liu; Hualiang Jiang
Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.
Bioorganic & medicinal chemistry letters 2006;16(19):5009-13.
2006: Jian Li; Jin-zhi Tan; Li-li Chen; Zhang Jian; Xu Shen; Chang-lin Mei; Li-li Fu; Li-Ping Lin; Jian Ding; Bing Xiong; Xi-shan Xiong; Hong Liu; Xiao-Min Luo; Hua-Liang Jiang
Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives.
Acta pharmacologica Sinica 2006;27(9):1259-71.
2006: Jian Li; Jing Chen; Li Zhang; Feng Wang; Chunshan Gui; Li Zhang; Yu Qin; Qiang Xu; Hong Liu; Fa-Jun Nan; Jingkang Shen; Donglu Bai; Kaixian Chen; Xu Shen; Hualiang Jiang
One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation.
Bioorganic & medicinal chemistry 2006;14(16):5527-34.
2006: Natalia Mast; Dilyara A Murtazina; Hong Liu; Sandra E Graham; Ingemar Bjorkhem; James Halpert; Julian Peterson; Irina A Pikuleva
Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies.
Biochemistry 2006;45(14):4396-404.
2006: Jian Li; Jing Chen; Chunshan Gui; Li Zhang; Yu Qin; Qiang Xu; Zhang Jian; Hong Liu; Xu Shen; Hualiang Jiang
Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay.
Bioorganic & medicinal chemistry 2006;14(7):2209-24.
2005: Weihua Li; Hong Liu; Emily E Scott; Frauke Gräter; James Halpert; Xiaoming Luo; Jianhua Shen; Hualiang Jiang
Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):910-9.
2005: Wataru Honma; Weihua Li; Hong Liu; Emily E Scott; James Halpert
Functional role of residues in the helix B' region of cytochrome P450 2B1.
Archives of biochemistry and biophysics 2005;435(1):157-65.
2004: Kunqian Yu; Wei Fu; Hong Liu; Xiaomin Luo; Kai Xian Chen; Jianping Ding; Jianhua Shen; Hualiang Jiang
Computational simulations of interactions of scorpion toxins with the voltage-gated potassium ion channel.
Biophysical journal 2004;86(6):3542-55.
2004: Emily E Scott; Hong Liu; You Qun He; Weihua Li; James Halpert
Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix.
Archives of biochemistry and biophysics 2004;423(2):266-76.
2003: Hong Liu; Yang Li; Mingke Song; Xiaojian Tan; Feng Cheng; Suxin Zheng; Jianhua Shen; Xiaomin Luo; Ruyun Ji; Jianmin Yue; Guoyuan Hu; Hualiang Jiang; Kaixian Chen
Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing.
Chemistry & biology 2003;10(11):1103-13.
2003: Jianhua Shen; Xiaoying Xu; Feng Cheng; Hong Liu; Xiaomin Luo; Jingkang Shen; Kaixian Chen; Weimin Zhao; Xu Shen; Hualiang Jiang
Virtual screening on natural products for discovering active compounds and target information.
Current medicinal chemistry 2003;10(21):2327-42.
2003: Santosh Kumar; Emily E Scott; Hong Liu; James Halpert
A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.
The Journal of biological chemistry 2003;278(19):17178-84.
2003: Kishore K Khan; Hong Liu; James Halpert
Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(4):356-9.
2003: Margit Spatzenegger; Hong Liu; Qinmi Wang; Andrea DeBarber; Dennis R Koop; James Halpert
Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.
The Journal of pharmacology and experimental therapeutics 2003;304(1):477-87.
2002: Hong Liu; Xiaoqin Huang; Jianhua Shen; Xiaomin Luo; Minghui Li; Bing Xiong; Gang Chen; Jingkang Shen; Yimin Yang; Hualiang Jiang; Kaixian Chen
Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.
Journal of medicinal chemistry 2002;45(22):4816-27.