FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kevin Barnham

Research Profile

Chemicals & Drugs

Disorders

Alzheimer's Disease

Living Beings

Mouse

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Procedures

Electron Spin Resonance Spectroscopy

Anatomy

Neurons

Co-author Network

Publications

TOP 3
Vijaya Kenche; Colin L Masters; Izabela Zawisza; Wojciech Bal; Kevin J Barnham; Simon C Drew
Mixed Ligand Cu(2+) Complexes of a Model Therapeutic with Alzheimer's Amyloid-β Peptide and Monoamine Neurotransmitters.
Andrew D Watt; Michelle Fodero-Tavoletti; Lin Wai Hung; Craig A Hutton; Timothy Johanssen; Woan Mei Kok; Colin L Masters; Catriona A McLean; Keyla A Perez; Alan Rembach; Nicki A Sherrat; Victor L Villemagne; Kevin J Barnham
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.
Vijaya Kenche; Jeffrey Kwok; Varsha Lal; Colin L Masters; Kazuma Murakami; Keyla Perez; Nikki Sherratt; Irene Volitakes; Roberto Cappai; Giuseppe D Ciccotosto; Mikhalina Cortes; Nicole Critch; Lin W Hung; Paul A Adlard; Kevin J Barnham
Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kevin Barnham (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Vijaya Kenche; Colin L Masters; Izabela Zawisza; Wojciech Bal; Kevin J Barnham; Simon C Drew
Mixed Ligand Cu(2+) Complexes of a Model Therapeutic with Alzheimer's Amyloid-β Peptide and Monoamine Neurotransmitters.
Inorganic chemistry 2013;52(8):4303-18.
2013: Andrew D Watt; Michelle Fodero-Tavoletti; Lin Wai Hung; Craig A Hutton; Timothy Johanssen; Woan Mei Kok; Colin L Masters; Catriona A McLean; Keyla A Perez; Alan Rembach; Nicki A Sherrat; Victor L Villemagne; Kevin J Barnham
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.
Acta neuropathologica 2013;125(4):549-64.
2013: Vijaya Kenche; Jeffrey Kwok; Varsha Lal; Colin L Masters; Kazuma Murakami; Keyla Perez; Nikki Sherratt; Irene Volitakes; Roberto Cappai; Giuseppe D Ciccotosto; Mikhalina Cortes; Nicole Critch; Lin W Hung; Paul A Adlard; Kevin J Barnham
Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.
Angewandte Chemie (International ed. in English) 2013;52(12):3374-8.
2013: James A Duce; D I Finkelstein; T J Kilpatrick; L Q Lam; L Leone; A A Miller; Jack T Rogers; A Tsatsanis; S Ayton; Kevin J Barnham; H Butzkueven; J E Corbin; Ashley I Bush
Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.
Molecular psychiatry 2013;18(2):245-54.
2013: Andrew D Watt; Victor L Villemagne; Kevin J Barnham
Metals, membranes, and amyloid-β oligomers: key pieces in the Alzheimer's disease puzzle?
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S283-93.
2012: Peter J Crouch; Kevin J Barnham
Therapeutic redistribution of metal ions to treat Alzheimer's disease.
Accounts of chemical research 2012;45(9):1604-11.
2012: Lin W Hung; Kevin J Barnham
Modulating metals as a therapeutic strategy for Alzheimer's disease.
Future medicinal chemistry 2012;4(8):955-69.
2012: Lin W Hung; Su Ling Leong; SinChun Lim; Xiang Liu; Colin L Masters; Graeme O'Keefe; Chi L L Pham; Andrew K Powell; Blaine R Roberts; David M Shackleford; Nicki A Sherratt; Victor L Villemagne; Anthony R White; Simon Wilkins; Ashley I Bush; Roberto Cappai; Lesley Cheng; Robert A Cherny; Francis C K Chiu; Peter J Crouch; Janetta G Culvenor; Paul S Donnelly; David I Finkelstein; Jessica George; Andrew F Hill; Scott Ayton; Kevin J Barnham
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.
The Journal of experimental medicine 2012;209(4):837-54.
2012: Gawain McColl; Tara L Pukala; Blaine R Roberts; Christine M Roberts; Timothy M Ryan; Kevin J Barnham; Ashley I Bush; Vijaya Kenche; Christopher D Link; Colin L Masters; Robert A Cherny
Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.
Molecular neurodegeneration 2012;7():57.
2012: Andrew D Watt; Colin L Masters; Keyla Perez; Alan R Rembach; Victor L Villemagne; Kevin J Barnham
Variability in blood-based amyloid-beta assays: the need for consensus on pre-analytical processing.
Journal of Alzheimer's disease : JAD 2012;30(2):323-36.
2011: Peter J Crouch; Paul S Donnelly; Mark A Greenough; Lin W Hung; Colin L Masters; Alexandra I Mot; Sarah J Parker; Maria S Savva; Irene Volitakis; Paul A Adlard; Kevin J Barnham; Ashley I Bush; Robert A Cherny; Anthony R White
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
Journal of neurochemistry 2011;119(1):220-30.
2011: Michelle T Fodero-Tavoletti; Colin L Masters; Christopher C Rowe; Victor L Villemagne; Kevin J Barnham; Roberto Cappai
Amyloid-β: the seeds of darkness.
The international journal of biochemistry & cell biology 2011;43(9):1247-51.
2011: Vijaya B Kenche; Kevin J Barnham
Alzheimer's disease & metals: therapeutic opportunities.
British journal of pharmacology 2011;163(2):211-9.
2011: Michelle T Fodero-Tavoletti; Nobuyuki Okamura; Shozo Furumoto; Rachel S Mulligan; Andrea R Connor; Catriona A McLean; Diana Cao; Angela Rigopoulos; Glenn A Cartwright; Graeme J O'Keefe; Sylvia Gong; Paul A Adlard; Kevin J Barnham; Christopher C Rowe; Colin L Masters; Yukitsuka Kudo; Roberto Cappai; Kazuhiko Yanai; Victor L Villemagne
18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease.
Brain : a journal of neurology 2011;134(Pt 4):1089-100.
2011: Simon C Drew; Cathryn L Haigh; Helen M J Klemm; Colin L Masters; Steven J Collins; Kevin J Barnham; Victoria A Lawson
Optical imaging detects apoptosis in the brain and peripheral organs of prion-infected mice.
Journal of neuropathology and experimental neurology 2011;70(2):143-50.
2011: Laura Bica; Jodi Meyerowitz; Sarah J Parker; Aphrodite Caragounis; Tai Du; Brett M Paterson; Kevin J Barnham; Peter J Crouch; Anthony R White; Paul S Donnelly
Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2011;24(1):117-33.
2011: Giuseppe D Ciccotosto; Deborah J Tew; Simon C Drew; Danielle G Smith; Timothy Johanssen; Varsha Lal; Tong-Lay Crystal Lau; Keyla Perez; Cyril C Curtain; John D Wade; Frances Separovic; Colin L Masters; Jeffrey P Smith; Kevin J Barnham; Roberto Cappai
Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity.
Neurobiology of aging 2011;32(2):235-48.
2011: Pavithra C Amadoruge; Kevin J Barnham
Alzheimer's disease and metals: a review of the involvement of cellular membrane receptors in metallosignalling.
International journal of Alzheimer's disease 2011;2011():542043.
2011: Andrew D Watt; Keyla Perez; Noel G Faux; Kerryn E Pike; Christopher C Rowe; Pierrick Bourgeat; Olivier Salvado; Colin L Masters; Victor L Villemagne; Kevin J Barnham
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;24(1):47-59.
2010: Martin P Boland; Claire R Hatty; Frances Separovic; Andrew F Hill; Deborah J Tew; Kevin J Barnham; Cathryn L Haigh; Michael James; Colin L Masters; Steven J Collins
Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain.
The Journal of biological chemistry 2010;285(42):32282-92.
2010: James A Duce; Andrew Tsatsanis; Michael A Cater; Simon A James; Elysia Robb; Krutika Wikhe; Su Ling Leong; Keyla Perez; Timothy Johanssen; Mark A Greenough; Hyun-Hee Cho; Denise Galatis; Robert D. Moir; Colin L Masters; Catriona McLean; Rudolph E Tanzi; Roberto Cappai; Kevin J Barnham; Giuseppe D Ciccotosto; Jack T Rogers; Ashley I Bush
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Cell 2010;142(6):857-67.
2010: Agata Rekas; Robert B Knott; Anna Sokolova; Kevin J Barnham; Keyla A Perez; Colin L Masters; Simon C Drew; Roberto Cappai; Cyril C Curtain; Chi L L Pham
The structure of dopamine induced alpha-synuclein oligomers.
European biophysics journal : EBJ 2010;39(10):1407-19.
2010: Sinchun Lim; Brett M Paterson; Michelle T Fodero-Tavoletti; Graeme J O'Keefe; Roberto Cappai; Kevin J Barnham; Victor L Villemagne; Paul S Donnelly
A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.
Chemical communications (Cambridge, England) 2010;46(30):5437-9.
2010: Katarina Kågedal; Woojin Scott Kim; Hanna Appelqvist; Sharon Chan; Danni Cheng; Lotta Agholme; Kevin J Barnham; Heather McCann; Glenda Halliday; Brett Garner
Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease.
Biochimica et biophysica acta 2010;1801(8):831-8.
2010: Christopher F Harrison; Victoria A Lawson; Bradley M Coleman; Yong-Sun Kim; Colin L Masters; Roberto Cappai; Kevin J Barnham; Andrew Hill
Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity.
The Journal of biological chemistry 2010;285(26):20213-23.
2010: Fredrik Haeffner; Kevin J Barnham; Ashley I Bush; Tore Brinck
Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study.
Journal of molecular modeling 2010;16(6):1103-8.
2010: Victor L Villemagne; Keyla Perez; Kerryn E Pike; W Mei Kok; Christopher C Rowe; Anthony R White; Pierrick Bourgeat; Olivier Salvado; Justin Bedo; Craig A Hutton; Noel G Faux; Colin L Masters; Kevin J Barnham
Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(18):6315-22.
2010: SinChun Lim; Katherine A Price; Siow-Feng Chong; Brett M Paterson; Aphrodite Caragounis; Kevin J Barnham; Peter J Crouch; Josephine M Peach; Jonathan R Dilworth; Anthony R White; Paul S Donnelly
Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(2):225-35.
2010: Simon C Drew; Colin L Masters; Kevin J Barnham
Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.
PloS one 2010;5(12):e15875.
2010: Woojin Scott Kim; Surabhi Bhatia; David A Elliott; Lotta Agholme; Katarina Kågedal; Heather McCann; Glenda M Halliday; Kevin J Barnham; Brett Garner
Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons.
Journal of Alzheimer's disease : JAD 2010;21(1):193-205.
2010: Michelle T Fodero-Tavoletti; Victor L Villemagne; Brett M Paterson; Anthony R White; Qiao-Xin Li; James Camakaris; Graeme O'Keefe; Roberto Cappai; Kevin J Barnham; Paul S Donnelly
Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;20(1):49-55.
2010: Danielle G Smith; Giuseppe D Ciccotosto; Deborah J Tew; Keyla Perez; Cyril C Curtain; John F Boas; Colin L Masters; Roberto Cappai; Kevin J Barnham
Histidine 14 modulates membrane binding and neurotoxicity of the Alzheimer's disease amyloid-beta peptide.
Journal of Alzheimer's disease : JAD 2010;19(4):1387-400.
2009: Katherine Ann Price; Aphrodite Caragounis; Brett M Paterson; Gulay Filiz; Irene Volitakis; Colin L Masters; Kevin J Barnham; Paul S Donnelly; Peter J Crouch; Anthony R White
Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.
Journal of medicinal chemistry 2009;52(21):6606-20.
2009: W Mei Kok; Denis B Scanlon; John A Karas; Luke A Miles; Deborah J Tew; Michael W Parker; Kevin J Barnham; Craig A Hutton
Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide.
Chemical communications (Cambridge, England) 2009;(41):6228-30.
2009: Su Ling Leong; Roberto Cappai; Kevin J Barnham; Chi Le Lan Pham
Modulation of alpha-synuclein aggregation by dopamine: a review.
Neurochemical research 2009;34(10):1838-46.
2009: Gawain McColl; Blaine R Roberts; Adam P Gunn; Keyla A Perez; Deborah J Tew; Colin L Masters; Kevin J Barnham; Robert A Cherny; Ashley I Bush
The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.
The Journal of biological chemistry 2009;284(34):22697-702.
2009: Simon C Drew; Colin L Masters; Kevin J Barnham
Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.
Journal of the American Chemical Society 2009;131(25):8760-1.
2009: Cathryn L Haigh; Simon C Drew; Martin P Boland; Colin L Masters; Kevin J Barnham; Victoria A Lawson; Steven J Collins
Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.
Journal of cell science 2009;122(Pt 10):1518-28.
2009: Su Ling Leong; Chi L L Pham; Denise Galatis; Michelle T Fodero-Tavoletti; Keyla Perez; Andrew Hill; Colin L Masters; Feda E Ali; Kevin J Barnham; Roberto Cappai
Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation.
Free radical biology & medicine 2009;46(10):1328-37.
2009: Chi L L Pham; Su Ling Leong; Feda E Ali; Vijaya Kenche; Andrew Hill; Sally L Gras; Kevin J Barnham; Roberto Cappai
Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner.
Journal of molecular biology 2009;387(3):771-85.
2009: Peter J Crouch; Deborah J Tew; Tai Du; Diem Ngoc Nguyen; Aphrodite Caragounis; Gulay Filiz; Rachel E Blake; Ian A Trounce; Cynthia P W Soon; Katrina M Laughton; Keyla A Perez; Qiao-Xin Li; Robert A Cherny; Colin L Masters; Kevin J Barnham; Anthony R White
Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation.
Journal of neurochemistry 2009;108(5):1198-207.
2009: Simon C Drew; Christopher J Noble; Colin L Masters; Graeme R Hanson; Kevin J Barnham
Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide.
Journal of the American Chemical Society 2009;131(3):1195-207.
2009: Peter J Crouch; Lin Wai Hung; Paul A Adlard; Mikhalina Cortes; Varsha Lal; Gulay Filiz; Keyla Perez; Milawaty Nurjono; Aphrodite Caragounis; Tai Du; Katrina Laughton; Irene Volitakis; Ashley I Bush; Qiao-Xin Li; Colin L Masters; Roberto Cappai; Robert A Cherny; Paul S Donnelly; Anthony R White; Kevin J Barnham
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):381-6.
2009: Yif'at Biran; Colin L Masters; Kevin J Barnham; Ashley I Bush; Paul A Adlard
Pharmacotherapeutic targets in Alzheimer's disease.
Journal of cellular and molecular medicine 2009;13(1):61-86.
2008: R Naylor; Andrew Hill; Kevin J Barnham
Is covalently crosslinked Abeta responsible for synaptotoxicity in Alzheimer's disease?
Current Alzheimer research 2008;5(6):533-9.
2008: Lin Wai Hung; Giuseppe D Ciccotosto; Eleni Giannakis; Deborah J Tew; Keyla Perez; Colin L Masters; Roberto Cappai; John D Wade; Kevin J Barnham
Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):11950-8.
2008: Victor A Streltsov; Stephen J Titmuss; V Chandana Epa; Kevin J Barnham; Colin L Masters; Joseph N Varghese
The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.
Biophysical journal 2008;95(7):3447-56.
2008: Simon C Drew; Karrera Y Djoko; Lianyi Zhang; Melissa Koay; John F Boas; John R Pilbrow; Zhiguang Xiao; Kevin J Barnham; Anthony G Wedd
Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(6):899-907.
2008: Paul A Adlard; Robert A Cherny; David Finkelstein; Elisabeth Gautier; Elysia Robb; Mikhalina Cortes; Irene Volitakis; Xiang Liu; Jeffrey P Smith; Keyla Perez; Katrina Laughton; Qiao-Xin Li; Susan A Charman; Joseph A Nicolazzo; Simon Wilkins; Karolina Deleva; Toni Lynch; Gaik Kok; Craig W Ritchie; Rudolph E Tanzi; Roberto Cappai; Colin L Masters; Kevin J Barnham; Ashley I Bush
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Neuron 2008;59(1):43-55.
2008: Simon C Drew; Su Ling Leong; Chi L L Pham; Deborah J Tew; Colin L Masters; Luke A Miles; Roberto Cappai; Kevin J Barnham
Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy.
Journal of the American Chemical Society 2008;130(24):7766-73.
2008: Kevin J Barnham; Vijaya Kenche; Giuseppe D Ciccotosto; David P Smith; Deborah J Tew; Xiang Liu; Keyla Perez; Greg A Cranston; Timothy J Johanssen; Irene Volitakis; Ashley I Bush; Colin L Masters; Anthony R White; Jeffrey P Smith; Robert A Cherny; Roberto Cappai
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6813-8.
2008: Kwok S Wun; Luke A Miles; Gabriela A N Crespi; Kaye Wycherley; David B Ascher; Kevin J Barnham; Roberto Cappai; Konrad Beyreuther; Colin L Masters; Michael W Parker; William J McKinstry
Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 5):438-41.
2008: Robyn A Sharples; Laura J Vella; Rebecca M Nisbet; Ryan Naylor; Keyla Perez; Kevin J Barnham; Colin L Masters; Andrew Hill
Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1469-78.
2008: Kevin J Barnham; Ashley I Bush
Metals in Alzheimer's and Parkinson's diseases.
Current opinion in chemical biology 2008;12(2):222-8.
2008: Eleni Giannakis; Jessica Pacífico; David P Smith; Lin Wai Hung; Colin L Masters; Roberto Cappai; John D Wade; Kevin J Barnham
Dimeric structures of alpha-synuclein bind preferentially to lipid membranes.
Biochimica et biophysica acta 2008;1778(4):1112-9.
2008: Deborah J Tew; Stephen P Bottomley; David P Smith; Giuseppe D Ciccotosto; jeffrey babon; Mark G Hinds; Colin L Masters; Roberto Cappai; Kevin J Barnham
Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide.
Biophysical journal 2008;94(7):2752-66.
2008: Luke A Miles; Kwok S Wun; Gabriela A N Crespi; Michelle T Fodero-Tavoletti; Denise Galatis; Christopher J Bagley; Konrad Beyreuther; Colin L Masters; Roberto Cappai; William J McKinstry; Kevin J Barnham; Michael W Parker
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.
Journal of molecular biology 2008;377(1):181-92.
2008: Ryan Naylor; Andrew Hill; Kevin J Barnham
Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?
European biophysics journal : EBJ 2008;37(3):265-8.
2008: Geoffrey K-W Kong; Luke A Miles; Gabriela A N Crespi; Craig J Morton; Hooi-Ling Ng; Kevin J Barnham; William J McKinstry; Roberto Cappai; Michael W Parker
Copper binding to the Alzheimer's disease amyloid precursor protein.
European biophysics journal : EBJ 2008;37(3):269-79.
2008: Roberto Cappai; Kevin J Barnham
Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity.
Neurochemical research 2008;33(3):526-32.
2008: Paul S Donnelly; Aphrodite Caragounis; Tai Du; Katrina M Laughton; Irene Volitakis; Robert A Cherny; Robyn A Sharples; Andrew Hill; Qiao-Xin Li; Colin L Masters; Kevin J Barnham; Anthony R White
Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide.
The Journal of biological chemistry 2008;283(8):4568-77.
2008: David P Smith; Deborah J Tew; Andrew Hill; Stephen P Bottomley; Colin L Masters; Kevin J Barnham; Roberto Cappai
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein.
Biochemistry 2008;47(5):1425-34.
2008: Eleni Giannakis; Lin-Wai Hung; Keyla Perez Camacaro; David P Smith; Kevin J Barnham; John D Wade
Analysis of Abeta interactions using ProteinChip technology.
Methods in molecular biology (Clifton, N.J.) 2008;494():71-86.
2008: Simon C Drew; Kevin J Barnham
Biophysical investigations of the prion protein using electron paramagnetic resonance.
Methods in molecular biology (Clifton, N.J.) 2008;459():173-96.
2008: Katherine A Price; Gulay Filiz; Aphrodite Caragounis; Tai Du; Katrina M Laughton; Colin L Masters; Robyn A Sharples; Andrew Hill; Qiao-Xin Li; Paul S Donnelly; Kevin J Barnham; Peter J Crouch; Anthony R White
Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide.
The international journal of biochemistry & cell biology 2008;40(9):1901-17.
2007: Christopher F Harrison; Kevin J Barnham; Andrew Hill
Neurotoxic species in prion disease: a role for PrP isoforms?
Journal of neurochemistry 2007;103(5):1709-20.
2007: Tong-Lay Crystal Lau; John D Gehman; John D Wade; Colin L Masters; Kevin J Barnham; Frances Separovic
Cholesterol and Clioquinol modulation of A beta(1-42) interaction with phospholipid bilayers and metals.
Biochimica et biophysica acta 2007;1768(12):3135-44.
2007: Aphrodite Caragounis; Tai Du; Gulay Filiz; Katrina M Laughton; Irene Volitakis; Robyn A Sharples; Robert A Cherny; Colin L Masters; Simon C Drew; Andrew Hill; Qiao-Xin Li; Peter J Crouch; Kevin J Barnham; Anthony R White
Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.
The Biochemical journal 2007;407(3):435-50.
2007: Tong-Lay Crystal Lau; John D Gehman; John D Wade; Keyla Perez; Colin L Masters; Kevin J Barnham; Frances Separovic
Membrane interactions and the effect of metal ions of the amyloidogenic fragment Abeta(25-35) in comparison to Abeta(1-42).
Biochimica et biophysica acta 2007;1768(10):2400-8.
2007: Michelle T Fodero-Tavoletti; David P Smith; Catriona A McLean; Paul A Adlard; Kevin J Barnham; Lisa E Foster; Laura Leone; Keyla Perez; Mikhalina Cortés; Janetta G Culvenor; Qiao-Xin Li; Katrina M Laughton; Christopher C Rowe; Colin L Masters; Roberto Cappai; Victor L Villemagne
In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(39):10365-71.
2007: Danielle G Smith; Roberto Cappai; Kevin J Barnham
The redox chemistry of the Alzheimer's disease amyloid beta peptide.
Biochimica et biophysica acta 2007;1768(8):1976-90.
2007: Geoffrey K-W Kong; Julian J Adams; Hugh H Harris; John F Boas; Cyril C Curtain; Denise Galatis; Colin L Masters; Kevin J Barnham; William J McKinstry; Roberto Cappai; Michael W Parker
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
Journal of molecular biology 2007;367(1):148-61.
2007: David P Smith; Giuseppe D Ciccotosto; Deborah J Tew; Michelle T Fodero-Tavoletti; Timothy Johanssen; Colin L Masters; Kevin J Barnham; Roberto Cappai
Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.
Biochemistry 2007;46(10):2881-91.
2006: Peter J Crouch; Kevin J Barnham; Ashley I Bush; Anthony R White
Therapeutic treatments for Alzheimer's disease based on metal bioavailability.
Drug news & perspectives 2006;19(8):469-74.
2006: Peter J Crouch; Kevin J Barnham; James A Duce; Rachel E Blake; Colin L Masters; Ian A Trounce
Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide.
Journal of neurochemistry 2006;99(1):226-36.
2006: Kevin J Barnham; Roberto Cappai; Konrad Beyreuther; Colin L Masters; Andrew Hill
Delineating common molecular mechanisms in Alzheimer's and prion diseases.
Trends in biochemical sciences 2006;31(8):465-72.
2006: Anthony R White; Tai Du; Katrina M Laughton; Irene Volitakis; Robyn A Sharples; Michel E Xilinas; David E Hoke; R. M. Damian Holsinger; Geneviève Evin; Robert A Cherny; Andrew Hill; Kevin J Barnham; Qiao-Xin Li; Ashley I Bush; Colin L Masters
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
The Journal of biological chemistry 2006;281(26):17670-80.
2006: David P Smith; Danielle G Smith; Cyril C Curtain; John F Boas; John R Pilbrow; Giuseppe D Ciccotosto; Tong-Lay Crystal Lau; Deborah J Tew; Keyla Perez; John D Wade; Ashley I Bush; Simon C Drew; Frances Separovic; Colin L Masters; Roberto Cappai; Kevin J Barnham
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.
The Journal of biological chemistry 2006;281(22):15145-54.
2006: Colin L Masters; Roberto Cappai; Kevin J Barnham; Victor L Villemagne
Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.
Journal of neurochemistry 2006;97(6):1700-25.
2006: Anthony R White; Kevin J Barnham; Ashley I Bush
Metal homeostasis in Alzheimer's disease.
Expert review of neurotherapeutics 2006;6(5):711-22.
2006: Tong-Lay Crystal Lau; Ernesto E Ambroggio; Deborah J Tew; Roberto Cappai; Colin L Masters; Gerardo D Fidelio; Kevin J Barnham; Frances Separovic
Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
Journal of molecular biology 2006;356(3):759-70.
2006: Carlos Opazo; Sandra Luza; Victor L Villemagne; Irene Volitakis; Christopher C Rowe; Kevin J Barnham; Dorothea Strozyk; Colin L Masters; Robert A Cherny; Ashley I Bush
Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease.
Aging cell 2006;5(1):69-79.
2006: Feda E Ali; Andrew Leung; Robert A Cherny; Christine Mavros; Kevin J Barnham; Frances Separovic; Colin J Barrow
Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine.
Free radical research 2006;40(1):1-9.
2005: Fredrik Haeffner; Danielle G Smith; Kevin J Barnham; Ashley I Bush
Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry.
Journal of inorganic biochemistry 2005;99(12):2403-22.
2005: Luigi Puglielli; Avi Friedlich; Kenneth D R Setchell; Seiichi Nagano; Carlos Opazo; Robert A Cherny; Kevin J Barnham; John D Wade; Simon Melov; Dora M. Kovacs; Ashley I Bush
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
The Journal of clinical investigation 2005;115(9):2556-63.
2005: Roberto Cappai; Su-Ling Leck; Deborah J Tew; Nicholas A Williamson; David P Smith; Denise Galatis; Robyn A Sharples; Cyril C Curtain; Feda E Ali; Robert A Cherny; Janetta G Culvenor; Stephen P Bottomley; Colin L Masters; Kevin J Barnham; Andrew Hill
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1377-9.
2005: Feda E Ali; Frances Separovic; Colin J Barrow; Robert A Cherny; Fiona Fraser; Ashley I Bush; Colin L Masters; Kevin J Barnham
Methionine regulates copper/hydrogen peroxide oxidation products of Abeta.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(6):353-60.
2005: Anna K Tickler; Danielle G Smith; Giuseppe D Ciccotosto; Deborah J Tew; Cyril C Curtain; Darryl Carrington; Colin L Masters; Ashley I Bush; Robert A Cherny; Roberto Cappai; John D Wade; Kevin J Barnham
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
The Journal of biological chemistry 2005;280(14):13355-63.
2005: Ernesto E Ambroggio; Dennis H Kim; Frances Separovic; Colin J Barrow; Kevin J Barnham; Luis A Bagatolli; Gerardo D Fidelio
Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide.
Biophysical journal 2005;88(4):2706-13.
2005: Peter J Crouch; Rachel Blake; James A Duce; Giuseppe D Ciccotosto; Qiao-Xin Li; Kevin J Barnham; Cyril C Curtain; Robert A Cherny; Roberto Cappai; Thomas Dyrks; Colin L Masters; Ian A Trounce
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(3):672-9.
2005: Geoffrey K-W Kong; Denise Galatis; Kevin J Barnham; Galina Polekhina; Julian J Adams; Colin L Masters; Roberto Cappai; Michael W Parker; William J McKinstry
Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 1):93-5.
2004: Giuseppe D Ciccotosto; Deborah J Tew; Cyril C Curtain; Danielle Smith; Darryl Carrington; Colin L Masters; Ashley I Bush; Robert A Cherny; Roberto Cappai; Kevin J Barnham
Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution.
The Journal of biological chemistry 2004;279(41):42528-34.
2004: Hong He; B Philip Shehan; Kevin J Barnham; Raymond S Norton; Arthur Shulkes; Graham S Baldwin
Biological activity and ferric ion binding of fragments of glycine-extended gastrin.
Biochemistry 2004;43(37):11853-61.
2004: Kevin J Barnham; Fredrik Haeffner; Giuseppe D Ciccotosto; Cyril C Curtain; Deborah J Tew; Christine Mavros; Konrad Beyreuther; Darryl Carrington; Colin L Masters; Robert A Cherny; Roberto Cappai; Ashley I Bush
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1427-9.
2004: Agata Rekas; Christopher G Adda; J Andrew Aquilina; Kevin J Barnham; Margaret Sunde; Denise Galatis; Nicholas A Williamson; Colin L Masters; Robin F Anders; Carol V Robinson; Roberto Cappai; John A Carver
Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
Journal of molecular biology 2004;340(5):1167-83.
2004: Shenggen Yao; Robert A Cherny; Ashley I Bush; Colin L Masters; Kevin J Barnham
Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(4):210-7.
2004: Anthony R White; Kevin J Barnham; Xudong Huang; Irene Voltakis; Konrad Beyreuther; Colin L Masters; Robert A Cherny; Ashley I Bush; Roberto Cappai
Iron inhibits neurotoxicity induced by trace copper and biological reductants.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):269-80.
2004: Kevin J Barnham; Colin L Masters; Ashley I Bush
Neurodegenerative diseases and oxidative stress.
Nature reviews. Drug discovery 2004;3(3):205-14.
2004: Julie Pannequin; Suzana Kovac; John-Paul Tantiongco; Raymond S Norton; Arthur Shulkes; Kevin J Barnham; Graham S Baldwin
A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin.
The Journal of biological chemistry 2004;279(4):2453-60.
2004: Feda E Ali; Kevin J Barnham; Colin J Barrow; Frances Separovic
Metal catalyzed oxidation of tyrosine residues by different oxidation systems of copper/hydrogen peroxide.
Journal of inorganic biochemistry 2004;98(1):173-84.
2003: Kevin J Barnham; Giuseppe D Ciccotosto; Anna K Tickler; Feda E Ali; Danielle G Smith; Nicholas A Williamson; Yuen-Han Lam; Darryl Carrington; Deborah J Tew; Gulcan Kocak; Irene Volitakis; Frances Separovic; Colin J Barrow; John D Wade; Colin L Masters; Robert A Cherny; Cyril C Curtain; Ashley I Bush; Roberto Cappai
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
The Journal of biological chemistry 2003;278(44):42959-65.
2003: Randa Bahadi; Peter V Farrelly; Bronwyn L Kenna; Cyril C Curtain; Colin L Masters; Roberto Cappai; Kevin J Barnham; Joseph I Kourie
Cu2+-induced modification of the kinetics of A beta(1-42) channels.
American journal of physiology. Cell physiology 2003;285(4):C873-80.
2003: Kevin J Barnham; William J McKinstry; Gerd Multhaup; Denise Galatis; Craig J Morton; Cyril C Curtain; Nicholas A Williamson; Anthony R White; Mark G Hinds; Raymond S Norton; Konrad Beyreuther; Colin L Masters; Michael W Parker; Roberto Cappai
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
The Journal of biological chemistry 2003;278(19):17401-7.
2003: Joseph I Kourie; Bronwyn L Kenna; D Tew; M F Jobling; Cyril C Curtain; Colin L Masters; Kevin J Barnham; Roberto Cappai
Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments.
The Journal of membrane biology 2003;193(1):35-45.
2003: Cyril C Curtain; Feda E Ali; Danielle G Smith; Ashley I Bush; Colin L Masters; Kevin J Barnham
Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid.
The Journal of biological chemistry 2003;278(5):2977-82.
2002: Julie Pannequin; Kevin J Barnham; Frédéric Hollande; Arthur Shulkes; Raymond S Norton; Graham S Baldwin
Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin.
The Journal of biological chemistry 2002;277(50):48602-9.
2002: Luke A Miles; Catherine Dy; Jake Nielsen; Kevin J Barnham; Mark G Hinds; Baldomero M Olivera; Grzegorz Bulaj; Raymond S Norton
Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.
The Journal of biological chemistry 2002;277(45):43033-40.
2002: Dean Hewish; Kevin J Barnham; Jerome A Werkmeister; Alan Kirkpatrick; Nicola Bartone; Su Ting Liu; Raymond S Norton; Cyril C Curtain; Donald E Rivetta
Structure and activity of D-Pro14 melittin.
Journal of protein chemistry 2002;21(4):243-53.
2001: Jeffrey J Gorman; Jennifer L McKimm-Breschkin; Raymond S Norton; Kevin J Barnham
Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein.
The Journal of biological chemistry 2001;276(42):38988-94.
2001: Gerardo Corzo; pierre escoubas; Villegas Villarreal Elba Crsitina; Kevin J Barnham; W He; R S Norton; Terumi Nakajima
Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.
The Biochemical journal 2001;359(Pt 1):35-45.
2001: Michael F Jobling; Xudong Huang; Leanne R Stewart; Kevin J Barnham; Cyril C Curtain; Irene Volitakis; Matthew A Perugini; Anthony R White; Robert A Cherny; Colin L Masters; Colin J Barrow; Steven J Collins; Ashley I Bush; Roberto Cappai
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
Biochemistry 2001;40(27):8073-84.
2001: Cyril C Curtain; F Ali; Irene Volitakis; Robert A Cherny; Raymond S Norton; Konrad Beyreuther; Colin J Barrow; Colin L Masters; Ashley I Bush; Kevin J Barnham
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
The Journal of biological chemistry 2001;276(23):20466-73.
2001: Robert A Cherny; Craig S Atwood; Michel E Xilinas; D N Gray; Walton D Jones; Catriona A McLean; Kevin J Barnham; Irene Volitakis; Fiona Fraser; Y Kim; Xudong Huang; Lee E Goldstein; Robert D. Moir; JT Lim; Konrad Beyreuther; Hui Zheng; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2001: A J Thompson; Kevin J Barnham; Raymond S Norton; Colin J Barrow
The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrP(C).
Biochimica et biophysica acta 2001;1544(1-2):242-54.
2000: Robert A Cherny; Kevin J Barnham; T Lynch; Irene Volitakis; Qiao-Xin Li; Catriona A McLean; Gerd Multhaup; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
1999: Kevin J Barnham; F Catalfamo; Paul K Pallaghy; G J Howlett; Raymond S Norton
Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity.
Biochimica et biophysica acta 1999;1435(1-2):127-37.
1999: M C Cox; Kevin J Barnham; T A Frenkiel; J D Hoeschele; Anne Mason; Qing-Yu He; Robert C Woodworth; Peter J Sadler
Identification of platination sites on human serum transferrin using (13)C and (15)N NMR spectroscopy.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(5):621-31.
1998: Kevin J Barnham; A M Torres; Dianne Alewood; Paul F Alewood; Teresa Domagala; Edouard Nice; Raymond S Norton
Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Protein science : a publication of the Protein Society 1998;7(8):1738-49.
1998: A I Ivanov; J Christodoulou; John A Parkinson; Kevin J Barnham; A Tucker; J Woodrow; Peter J Sadler
Cisplatin binding sites on human albumin.
The Journal of biological chemistry 1998;273(24):14721-30.
1997: Kevin J Barnham; T R Dyke; William R Kem; Raymond S Norton
Structure of neurotoxin B-IV from the marine worm Cerebratulus lacteus: a helical hairpin cross-linked by disulphide bonding.
Journal of molecular biology 1997;268(5):886-902.
1997: Kevin J Barnham; S A Monks; M G Hinds; AA Azad; Raymond S Norton
Solution structure of a polypeptide from the N terminus of the HIV protein Nef.
Biochemistry 1997;36(20):5970-80.
1997: Susan J Berners-Price; A Corazza; Z Guo; Kevin J Barnham; Peter J Sadler; Y Ohyama; M Leng; D Locker
Structural transitions of a GG-platinated DNA duplex induced by pH, temperature and box A of high-mobility-group protein 1.
European journal of biochemistry / FEBS 1997;243(3):782-91.