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Hung-wen Liu

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Wei-chen Chang; Mishtu Dey; Catherine L Drennan; Pinghua Liu; Steven O Mansoorabadi; Sung-Ju Moon; Zongbao K Zhao; Hung-wen Liu
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.
Hak Joong Kim; Mark W Ruszczycky; choi seihyun; Yung-nan Liu; Hung-wen Liu
Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A.
Yasushi Ogasawara; Hung-wen Liu
Biosynthetic studies of aziridine formation in azicemicins.

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All Publications

2013: Wei-chen Chang; Mishtu Dey; Catherine L Drennan; Pinghua Liu; Steven O Mansoorabadi; Sung-Ju Moon; Zongbao K Zhao; Hung-wen Liu
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.
Nature 2013;496(7443):114-8.
2011: Hak Joong Kim; Mark W Ruszczycky; choi seihyun; Yung-nan Liu; Hung-wen Liu
Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A.
Nature 2011;473(7345):109-12.
2009: Yasushi Ogasawara; Hung-wen Liu
Biosynthetic studies of aziridine formation in azicemicins.
Journal of the American Chemical Society 2009;131(50):18066-8.
2009: Ping-Hui Szu; Mark W Ruszczycky; choi seihyun; Feng Yan; Hung-wen Liu
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.
Journal of the American Chemical Society 2009;131(39):14030-42.
2009: Jeffrey W Munos; Xiaotao Pu; Steven O Mansoorabadi; Hak Joong Kim; Hung-wen Liu
A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement.
Journal of the American Chemical Society 2009;131(6):2048-9.
2009: Jessica White-Phillip; Christopher J Thibodeaux; Hung-wen Liu
Enzymatic synthesis of TDP-deoxysugars.
Methods in enzymology 2009;459():521-44.
2008: Jeffrey W Munos; Xiaotao Pu; Hung-wen Liu
Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Bioorganic & medicinal chemistry letters 2008;18(10):3090-4.
2008: Lin Hong; Zongbao Zhao; Charles E Melançon; Hua Zhang; Hung-wen Liu
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.
Journal of the American Chemical Society 2008;130(14):4954-67.
2007: Hak Joong Kim; Rongson Pongdee; Qingquan Wu; Lin Hong; Hung-wen Liu
The biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of the cross-bridging precursor and identification of the function of SpnJ.
Journal of the American Chemical Society 2007;129(47):14582-4.
2007: Hua Zhang; Jess A White-Phillip; Charles E Melançon; Hyung-jin Kwon; Wei-luen Yu; Hung-wen Liu
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.
Journal of the American Chemical Society 2007;129(47):14670-83.
2007: Feng Yan; Sung-Ju Moon; Pinghua Liu; Zongbao Zhao; John D Lipscomb; Aimin Liu; Hung-wen Liu
Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues.
Biochemistry 2007;46(44):12628-38.
2007: Steven O Mansoorabadi; Christopher J Thibodeaux; Hung-wen Liu
The diverse roles of flavin coenzymes--nature's most versatile thespians.
The Journal of organic chemistry 2007;72(17):6329-42.
2007: William Kittleman; Christopher J Thibodeaux; Yung-nan Liu; Hua Zhang; Hung-wen Liu
Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus.
Biochemistry 2007;46(28):8401-13.
2007: Christopher J Thibodeaux; Charles E Melançon; Hung-wen Liu
Unusual sugar biosynthesis and natural product glycodiversification.
Nature 2007;446(7139):1008-16.
2007: Charles E Melançon; Hung-wen Liu
Engineered biosynthesis of macrolide derivatives bearing the non-natural deoxysugars 4-epi-D-mycaminose and 3-n-monomethylamino-3-deoxy-D-fucose.
Journal of the American Chemical Society 2007;129(16):4896-7.
2007: Qingquan Wu; Yung-nan Liu; Huawei Chen; Erich J Molitor; Hung-wen Liu
A retro-evolution study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) from Yersinia pseudotuberculosis: implications for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses.
Biochemistry 2007;46(12):3759-67.
2007: Kenji Itoh; Zhishu Huang; Hung-wen Liu
Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: implication for an oxocarbenium ion intermediate in the catalytic mechanism.
Organic letters 2007;9(5):879-82.
2007: Charles E Melançon; Lin Hong; Jess A White; Yung-nan Liu; Hung-wen Liu
Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.
Biochemistry 2007;46(2):577-90.
2006: Lin Hong; Zongbao Zhao; Hung-wen Liu
Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis.
Journal of the American Chemical Society 2006;128(44):14262-3.
2006: Feng Yan; Jeffrey W Munos; Pinghua Liu; Hung-wen Liu
Biosynthesis of fosfomycin, re-examination and re-confirmation of a unique Fe(II)- and NAD(P)H-dependent epoxidation reaction.
Biochemistry 2006;45(38):11473-81.
2006: Charles E Melançon; Christopher J Thibodeaux; Hung-wen Liu
Glyco-stripping and glyco-swapping.
ACS chemical biology 2006;1(8):499-504.
2006: Hua Zhang; Ying Zhou; Hongbo Bao; Hung-wen Liu
Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC).
Biochemistry 2006;45(26):8163-73.
2006: Chai-Lin Kao; Svetlana A Borisova; Hak Joong Kim; Hung-wen Liu
Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: analysis and implications.
Journal of the American Chemical Society 2006;128(17):5606-7.
2006: Svetlana A Borisova; Changsheng Zhang; Haruko Takahashi; Hua Zhang; Alexander W Wong; Jon S Thorson; Hung-wen Liu
Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses.
Angewandte Chemie (International ed. in English) 2006;45(17):2748-53.
2006: Haruko Takahashi; Yung-nan Liu; Hung-wen Liu
A two-stage one-pot enzymatic synthesis of TDP-L-mycarose from thymidine and glucose-1-phosphate.
Journal of the American Chemical Society 2006;128(5):1432-3.
2005: Chai-Lin Kao; William Kittleman; Hua Zhang; Haruo Seto; Hung-wen Liu
Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates.
Organic letters 2005;7(25):5677-80.
2005: Ping-hui Szu; Xuemei He; Lishan Zhao; Hung-wen Liu
Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation.
Angewandte Chemie (International ed. in English) 2005;44(41):6742-6.
2005: Feng Yan; Tingfeng Li; John D Lipscomb; Aimin Liu; Hung-wen Liu
Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase.
Archives of biochemistry and biophysics 2005;442(1):82-91.
2005: Charles E Melançon; Wei-luen Yu; Hung-wen Liu
TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene.
Journal of the American Chemical Society 2005;127(35):12240-1.
2005: Haruko Takahashi; Yung-nan Liu; Huawei Chen; Hung-wen Liu
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
Journal of the American Chemical Society 2005;127(26):9340-1.
2005: Zongbao Zhao; Lin Hong; Hung-wen Liu
Characterization of protein encoded by spnR from the spinosyn gene cluster of Saccharopolyspora spinosa: mechanistic implications for forosamine biosynthesis.
Journal of the American Chemical Society 2005;127(21):7692-3.
2004: Charles E Melançon; Haruko Takahashi; Hung-wen Liu
Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.
Journal of the American Chemical Society 2004;126(51):16726-7.
2004: Jenefer Alam; Noelle Beyer; Hung-wen Liu
Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC).
Biochemistry 2004;43(51):16450-60.
2004: Gautam Agnihotri; Yung-nan Liu; Beth M Paschal; Hung-wen Liu
Identification of an unusual [2Fe-2S]-binding motif in the CDP-6-deoxy-D-glycero-l-threo-4-hexulose-3-dehydrase from Yersinia pseudotuberculosis: implication for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses.
Biochemistry 2004;43(44):14265-74.
2004: Rongson Pongdee; Hung-wen Liu
Elucidation of enzyme mechanisms using fluorinated substrate analogues.
Bioorganic chemistry 2004;32(5):393-437.
2004: Alexander Wong; Jeffrey W Munos; Vidusha Devasthali; Kenneth A Johnson; Hung-wen Liu
Study of 1-deoxy-D-xylulose-5-phosphate reductoisomerase: synthesis and evaluation of fluorinated substrate analogues.
Organic letters 2004;6(20):3625-8.
2004: Pinghua Liu; Mark P Mehn; Feng Yan; Zongbao Zhao; Lawrence Que; Hung-wen Liu
Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis.
Journal of the American Chemical Society 2004;126(33):10306-12.
2004: Subramanian Karthikeyan; Zongbao Zhao; Chai-Lin Kao; Qingxian Zhou; Zhihua Tao; Hong Zhang; Hung-wen Liu
Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile.
Angewandte Chemie (International ed. in English) 2004;43(26):3425-9.
2004: Svetlana A Borisova; Lishan Zhao; Charles E Melançon III; Chai-Lin Kao; Hung-wen Liu
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.
Journal of the American Chemical Society 2004;126(21):6534-5.
2003: Zhishu Huang; Qibo Zhang; Hung-wen Liu
Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications.
Bioorganic chemistry 2003;31(6):494-502.
2003: Pinghua Liu; Aimin Liu; Feng Yan; Matt D Wolfe; John D Lipscomb; Hung-wen Liu
Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme.
Biochemistry 2003;42(40):11577-86.
2003: Caroline Leriche; Xuemei He; Cheng-Wei T Chang; Hung-wen Liu
Reversal of the apparent regiospecificity of NAD(P)H-dependent hydride transfer: the properties of the difluoromethylene group, a carbonyl mimic.
Journal of the American Chemical Society 2003;125(21):6348-9.
2003: Noelle Beyer; Jenefer Alam; Tina M Hallis; Zhihong Guo; Hung-wen Liu
The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme.
Journal of the American Chemical Society 2003;125(19):5584-5.
2003: Zongbao Zhao; Huawei Chen; Keqiang Li; Wensheng Du; Shouming He; Hung-wen Liu
Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.
Biochemistry 2003;42(7):2089-103.
2003: Gautam Agnihotri; Hung-wen Liu
Enoyl-CoA hydratase. reaction, mechanism, and inhibition.
Bioorganic & medicinal chemistry 2003;11(1):9-20.
2002: Zongbao Zhao; Pinghua Liu; Kazuo Murakami; Tomohisa Kuzuyama; Haruo Seto; Hung-wen Liu
Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate.
Angewandte Chemie (International ed. in English) 2002;41(23):4529-32.
2002: Xuemei He; Hung-wen Liu
Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesis.
Current opinion in chemical biology 2002;6(5):590-7.
2002: Huawei Chen; Hiroshi Yamase; Kazuo Murakami; Cheng-Wei Chang; Lishan Zhao; Zongbao Zhao; Hung-wen Liu
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
Biochemistry 2002;41(29):9165-83.
2002: Cheng-Wei T Chang; Hung-wen Liu
Synthesis of TDP-3-amino-3,4,6-trideoxy-alpha-D-xylo-hexopyranose--the immediate precursor of TDP-alpha-D-desosamine.
Bioorganic & medicinal chemistry letters 2002;12(11):1493-6.
2002: Zongbao Zhao; Hung-wen Liu
Synthesis of labeled 1-amino-2-methylenecyclopropane-1-carboxylic acid, an inactivator of 1-aminocyclopropane-1-carboxylate deaminase.
The Journal of organic chemistry 2002;67(8):2509-14.
2002: Gautam Agnihotri; Shouming He; Lin Hong; Srikanth Dakoji; Stephen G Withers; Hung-wen Liu
A revised mechanism for the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA based on unexpected results with the C114A mutant.
Biochemistry 2002;41(6):1843-52.
2002: Xuemei M He; Hung-wen Liu
Formation of unusual sugars: mechanistic studies and biosynthetic applications.
Annual review of biochemistry 2002;71():701-54.
2001: Srikanth Dakoji; D Li; Gautam Agnihotri; H Q Zhou; Hung-wen Liu
Studies on the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA: elucidation of the inactivation mechanism and identification of cysteine-114 as the entrapped nucleophile.
Journal of the American Chemical Society 2001;123(40):9749-59.
2001: Gautam Agnihotri; Hung-wen Liu
PLP and PMP radicals: a new paradigm in coenzyme B6 chemistry.
Bioorganic chemistry 2001;29(4):234-57.