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Leroy Liu

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Ren-Kuo Lin; Leroy F Liu; Chia-Wen Ho; Yi Lisa Lyu
Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis.
Hsiao-Ling Chiang; Chia-Tse Hsu; Fan-Dan Jan; Chun-Cheng Lin; Chi-Yu Lin; Yaoh-Shiang Lin; Leroy F Liu; Shin Nieh; Jacqueline Whang-Peng; Jaulang Hwang
A novel synthetic bipartite carrier protein for developing glycotope-based vaccines.
Sui Zhang; Tasneem Bawa-Khalfe; Leroy F Liu; Xiaobing Liu; Long-Sheng Lu; Yi Lisa Lyu; Edward T H Yeh
Identification of the molecular basis of doxorubicin-induced cardiotoxicity.

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2013: Ren-Kuo Lin; Leroy F Liu; Chia-Wen Ho; Yi Lisa Lyu
Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis.
The Journal of biological chemistry 2013;288(10):7182-92.
2012: Hsiao-Ling Chiang; Chia-Tse Hsu; Fan-Dan Jan; Chun-Cheng Lin; Chi-Yu Lin; Yaoh-Shiang Lin; Leroy F Liu; Shin Nieh; Jacqueline Whang-Peng; Jaulang Hwang
A novel synthetic bipartite carrier protein for developing glycotope-based vaccines.
Vaccine 2012;30(52):7573-81.
2012: Sui Zhang; Tasneem Bawa-Khalfe; Leroy F Liu; Xiaobing Liu; Long-Sheng Lu; Yi Lisa Lyu; Edward T H Yeh
Identification of the molecular basis of doxorubicin-induced cardiotoxicity.
Nature medicine 2012;18(11):1639-42.
2012: Yee-Fun Su; Tsunghan Yang; Hoting Huang; Leroy F Liu; Jaulang Hwang
Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity.
PloS one 2012;7(4):e34250.
2012: Shan Wan; Ronald G Jubin; Yi Lisa Lyu; Sidney Pestka; Yu-Chen Tsai; Leroy F Liu
Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells.
PloS one 2012;7(3):e32542.
2011: Ren-Kuo Lin; Yu-tsung Chen; Ziqiang Guan; Tao-shih Hsieh; John Kerrigan; Chang-Hsien Lu; Yi Lisa Lyu; Yuan-Chin Tsai; Nai Zhou; Leroy F Liu
Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.
The Journal of biological chemistry 2011;286(38):33591-600.
2011: Yu-Chen Tsai; Shan Wan; Lu-Hai Wang; Yi Lisa Lyu; Sidney Pestka; Loren W Runnels; Leroy F Liu
Interferon-β signaling contributes to Ras transformation.
PloS one 2011;6(8):e24291.
2011: Laurence M Wood; Surendran Sankar; Ryan E Reed; Arthur L Haas; Leroy F Liu; Peter McKinnon; Shyamal D Desai
A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway.
PloS one 2011;6(1):e16422.
2010: Anna M Azarova; Ren-Kuo Lin; Yuan-Chin Tsai; Leroy F Liu; Chao-Po Lin; Yi Lisa Lyu
Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia.
Biochemical and biophysical research communications 2010;399(1):66-71.
2010: Mavurapu Satyanarayana; Young-Ah Kim; Suzanne G Rzuczek; Daniel S Pilch; Angela A Liu; Leroy F Liu; Joseph E Rice; Edmond J LaVoie
Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity.
Bioorganic & medicinal chemistry letters 2010;20(10):3150-4.
2009: Chao-Po Lin; Yi Ban; Yi Lisa Lyu; Leroy F Liu
Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.
The Journal of biological chemistry 2009;284(41):28084-92.
2009: Wei Feng; Mavurapu Satyanarayana; Yuan-Chin Tsai; Angela A Liu; Leroy F Liu; Edmond J LaVoie
Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide.
European journal of medicinal chemistry 2009;44(9):3433-8.
2009: Yuan-Chin Tsai; Haiyan Qi; Chao-Po Lin; Ren-Kuo Lin; John E Kerrigan; Suzanne G Rzuczek; Edmond J LaVoie; Joseph E Rice; Daniel S Pilch; Yi Lisa Lyu; Leroy F Liu
A G-quadruplex stabilizer induces M-phase cell cycle arrest.
The Journal of biological chemistry 2009;284(34):22535-43.
2009: Wei Feng; Mavurapu Satyanarayana; Yuan-Chin Tsai; Angela A Liu; Leroy F Liu; Edmond J LaVoie
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.
Bioorganic & medicinal chemistry 2009;17(7):2877-85.
2009: Lisa Sharma; Yuan-Chin Tsai; Angela A Liu; Leroy F Liu; Edmond J LaVoie
Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
European journal of medicinal chemistry 2009;44(4):1471-6.
2008: Wei Feng; Mavurapu Satyanarayana; Liang Cheng; Angela Liu; Yuan-Chin Tsai; Leroy F Liu; Edmond J LaVoie
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Bioorganic & medicinal chemistry 2008;16(20):9295-301.
2008: Wei Feng; Mavurapu Satyanarayana; Yuan-Chin Tsai; Angela A Liu; Leroy F Liu; Edmond J LaVoie
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.
Bioorganic & medicinal chemistry 2008;16(18):8598-606.
2008: Mavurapu Satyanarayana; Wei Feng; Liang Cheng; Angela A Liu; Yuan-Chin Tsai; Leroy F Liu; Edmond J LaVoie
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
Bioorganic & medicinal chemistry 2008;16(16):7824-31.
2008: Chao-Po Lin; Yi Ban; Yi Lisa Lyu; Shyamal D Desai; Leroy F Liu
A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.
The Journal of biological chemistry 2008;283(30):21074-83.
2008: Mavurapu Satyanarayana; Suzanne G Rzuczek; Edmond J LaVoie; Daniel S Pilch; Angela Liu; Leroy F Liu; Joseph E Rice
Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency.
Bioorganic & medicinal chemistry letters 2008;18(13):3802-4.
2008: Wei Feng; Mavurapu Satyanarayana; Yuan-Chin Tsai; Angela A Liu; Leroy F Liu; Edmond J LaVoie
Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
Bioorganic & medicinal chemistry letters 2008;18(12):3570-2.
2008: Shyamal D Desai; Laurence M Wood; Yu-Chen Tsai; Tao-shih Hsieh; Jeffrey R Marks; Georgia L Scott; Beppino C Giovanella; Leroy F Liu
ISG15 as a novel tumor biomarker for drug sensitivity.
Molecular cancer therapeutics 2008;7(6):1430-9.
2008: Haiyan Qi; Yongjie Chen; Xuan Fu; Chao-Po Lin; X F Steven Zheng; Leroy F Liu
TOR regulates cell death induced by telomere dysfunction in budding yeast.
PloS one 2008;3(10):e3520.
2008: Xuan Fu; Shan Wan; Yi Lisa Lyu; Leroy F Liu; Haiyan Qi
Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation.
PloS one 2008;3(4):e2009.
2007: Yi Lisa Lyu; John E Kerrigan; Chao-Po Lin; Anna M Azarova; Yuan-Chin Tsai; Yi Ban; Leroy F Liu
Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.
Cancer research 2007;67(18):8839-46.
2007: Yong Zhang; Haiyan Qi; Robert Taylor; Weihong Xu; Leroy F Liu; Shengkan Jin
The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains.
Autophagy 2007;3(4):337-46.
2007: Yuan-Chin Tsai; Haiyan Qi; Leroy F Liu
Protection of DNA ends by telomeric 3' G-tail sequences.
The Journal of biological chemistry 2007;282(26):18786-92.
2007: Anna M Azarova; Yi Lisa Lyu; Chao-Po Lin; Yuan-Chin Tsai; Johnson Yiu-Nam Lau; James C Wang; Leroy F Liu
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):11014-9.
2007: Alam Nur-E-Kamal; Sally Meiners; Ijaz Ahmed; Anna M Azarova; Chao-Po Lin; Yi Lisa Lyu; Leroy F Liu
Role of DNA topoisomerase IIbeta in neurite outgrowth.
Brain research 2007;1154():50-60.
2007: Eszter S Hars; Haiyan Qi; Alexey G Ryazanov; Shengkan Jin; li cai; Chengcheng Hu; Leroy F Liu
Autophagy regulates ageing in C. elegans.
Autophagy 2007;3(2):93-5.
2007: Chi Kwan Tsang; Haiyan Qi; Leroy F Liu; X F Steven Zheng
Targeting mammalian target of rapamycin (mTOR) for health and diseases.
Drug discovery today 2007;12(3-4):112-24.
2006: Haiyan Qi; Chao-Po Lin; Xuan Fu; Laurence M Wood; Angela A Liu; Yuan-Chin Tsai; Yongjie Chen; Christopher M Barbieri; Daniel S Pilch; Leroy F Liu
G-quadruplexes induce apoptosis in tumor cells.
Cancer research 2006;66(24):11808-16.
2006: Ailing Zhang; Yi Lisa Lyu; Chao-Po Lin; Nai Zhou; Anna M Azarova; Laurence M Wood; Leroy F Liu
A protease pathway for the repair of topoisomerase II-DNA covalent complexes.
The Journal of biological chemistry 2006;281(47):35997-6003.
2006: Yi Lisa Lyu; Chao-Po Lin; Anna M Azarova; li cai; James C Wang; Leroy F Liu
Role of topoisomerase IIbeta in the expression of developmentally regulated genes.
Molecular and cellular biology 2006;26(21):7929-41.
2006: Eszter S Hars; Yi Lisa Lyu; Chao-Po Lin; Leroy F Liu
Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia.
Cancer research 2006;66(18):8975-9.
2006: Tsann-Long Su; Yi-Wen Lin; Ting-Chao Chou; Xiuguo Zhang; Valeriy A Bacherikov; Ching-Huang Chen; Leroy F Liu; Tsong-Jen Tsai
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Journal of medicinal chemistry 2006;49(12):3710-8.
2006: Shejin Zhu; Alexander L Ruchelman; Nai Zhou; Angela Liu; Leroy F Liu; Edmond J LaVoie
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
Bioorganic & medicinal chemistry 2006;14(9):3131-43.
2006: Meiluen Yang; Chia-Tse Hsu; chun-yuan ting; Leroy F Liu; Jaulang Hwang
Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro.
The Journal of biological chemistry 2006;281(12):8264-74.
2006: Shyamal D Desai; Arthur L Haas; Laurence M Wood; Yu-Chen Tsai; Sidney Pestka; Eric H Rubin; Ahamed Saleem; Alam Nur-E-Kamal; Leroy F Liu
Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.
Cancer research 2006;66(2):921-8.
2005: Shejin Zhu; Alexander L Ruchelman; Nai Zhou; Angela A Liu; Leroy F Liu; Edmond J LaVoie
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.
Bioorganic & medicinal chemistry 2005;13(24):6782-94.
2005: Valeriy A Bacherikov; Ting-Chao Chou; Hua-Jin Dong; Xiuguo Zhang; Ching-Huang Chen; Yi-Wen Lin; Tsong-Jen Tsai; Rong-Zau Lee; Leroy F Liu; Tsann-Long Su
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity.
Bioorganic & medicinal chemistry 2005;13(12):3993-4006.
2005: Alexander L Ruchelman; Peter J Houghton; Nai Zhou; Angela Liu; Leroy F Liu; Edmond J LaVoie
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
Journal of medicinal chemistry 2005;48(3):792-804.
2004: Alexander L Ruchelman; Shejin Zhu; Nai Zhou; Angela Liu; Leroy F Liu; Edmond J LaVoie
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Bioorganic & medicinal chemistry letters 2004;14(22):5585-9.
2004: Rajeev Rajendra; Diptee Malegaonkar; Pooja Pungaliya; Henderson Marshall; Zeshaan A Rasheed; James Brownell; Leroy F Liu; Stuart Lutzker; Ahamed Saleem; Eric H Rubin
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.
The Journal of biological chemistry 2004;279(35):36440-4.
2004: Alexander L Ruchelman; John E Kerrigan; Tsai-Kun Li; Nai Zhou; Angela Liu; Leroy F Liu; Edmond J LaVoie
Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.
Bioorganic & medicinal chemistry 2004;12(13):3731-42.
2004: Alam Nur-E-Kamal; Stephane R Gross; Zui Pan; Zita Balklava; Jianjie Ma; Leroy F Liu
Nuclear translocation of cytochrome c during apoptosis.
The Journal of biological chemistry 2004;279(24):24911-4.
2004: Parima Daroui; Shyamal D Desai; Tsai-Kun Li; Angela A Liu; Leroy F Liu
Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.
The Journal of biological chemistry 2004;279(15):14587-94.
2004: Alexander L Ruchelman; Sudhir K Singh; Abhijit Ray; Xiaohua Wu; Jin-Ming Yang; Nai Zhou; Angela Liu; Leroy F Liu; Edmond J LaVoie
11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
Bioorganic & medicinal chemistry 2004;12(4):795-806.
2003: Tsai-Kun Li; Peter J Houghton; Shyamal D Desai; Parima Daroui; Angela A Liu; Eszter S Hars; Alexander L Ruchelman; Edmond J LaVoie; Leroy F Liu
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Cancer research 2003;63(23):8400-7.
2003: chun-yuan ting; Chia-Tse Hsu; Hsiang-Ting Hsu; Jin-Shan Su; Tzong-Yueh Chen; Woan-Yuh Tarn; Yueh-Hsiung Kuo; Jacqueline Whang-Peng; Leroy F Liu; Jaulang Hwang
Isodiospyrin as a novel human DNA topoisomerase I inhibitor.
Biochemical pharmacology 2003;66(10):1981-91.
2003: Dajie Li; Baoping Zhao; Sai Peng Sim; Tsai-Kun Li; Angela Liu; Leroy F Liu; Edmond J LaVoie
8,9-methylenedioxybenzo[i]phenanthridines: topoisomerase I-targeting activity and cytotoxicity.
Bioorganic & medicinal chemistry 2003;11(17):3795-805.
2003: Nai Zhou; Hai Xiao; Tsai-Kun Li; Alam Nur-E-Kamal; Leroy F Liu
DNA damage-mediated apoptosis induced by selenium compounds.
The Journal of biological chemistry 2003;278(32):29532-7.
2003: Sudhir K Singh; Alexander L Ruchelman; Tsai-Kun Li; Angela Liu; Leroy F Liu; Edmond J LaVoie
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Journal of medicinal chemistry 2003;46(11):2254-7.
2003: Alexander L Ruchelman; Sudhir K Singh; Abhijit Ray; Xiao Hua Wu; Jin-Ming Yang; Tsai-Kun Li; Angela Liu; Leroy F Liu; Edmond J LaVoie
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
Bioorganic & medicinal chemistry 2003;11(9):2061-73.
2003: Hai Xiao; Tsai-Kun Li; Jin-Ming Yang; Leroy F Liu
Acidic pH induces topoisomerase II-mediated DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5205-10.
2003: Haiyan Qi; Tsai-Kun Li; Debbie Kuo; Alam Nur-E-Kamal; Leroy F Liu
Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast.
The Journal of biological chemistry 2003;278(17):15136-41.
2003: Darshan Makhey; Dajie Li; Baoping Zhao; Sai Peng Sim; Tsai-Kun Li; Angela Liu; Leroy F Liu; Edmond J LaVoie
Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.
Bioorganic & medicinal chemistry 2003;11(8):1809-20.
2003: Alam Nur-E-Kamal; Tsai-Kun Li; Ailing Zhang; Haiyan Qi; Eszter S Hars; Leroy F Liu
Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals.
The Journal of biological chemistry 2003;278(14):12475-81.
2003: Younong Yu; Sudhir K Singh; Angela Liu; Tsai-Kun Li; Leroy F Liu; Edmond J LaVoie
Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.
Bioorganic & medicinal chemistry 2003;11(7):1475-91.
2003: Shyamal D Desai; Hui Zhang; Alexandra Rodriguez-Bauman; Jin-Ming Yang; Xiaohua Wu; Murugesan K Gounder; Eric H Rubin; Leroy F Liu
Transcription-dependent degradation of topoisomerase I-DNA covalent complexes.
Molecular and cellular biology 2003;23(7):2341-50.
2003: Hai Xiao; Yong Mao; Shyamal D Desai; Nai Zhou; chun-yuan ting; Jaulang Hwang; Leroy F Liu
The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3239-44.
2003: Dajie Li; Baoping Zhao; Sai Peng Sim; Tsai-Kun Li; Angela Liu; Leroy F Liu; Edmond J LaVoie
2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents.
Bioorganic & medicinal chemistry 2003;11(4):521-8.
2002: Alexander L Ruchelman; Sudhir K Singh; Xiaohua Wu; Abhijit Ray; Jin-Ming Yang; Tsai-Kun Li; Angela Liu; Leroy F Liu; Edmond J LaVoie
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.
Bioorganic & medicinal chemistry letters 2002;12(22):3333-6.
2001: Yong Mao; Shyamal D Desai; chun-yuan ting; Jaulang Hwang; Leroy F Liu
26 S proteasome-mediated degradation of topoisomerase II cleavable complexes.
The Journal of biological chemistry 2001;276(44):40652-8.
2001: Sai Peng Sim; Leroy F Liu
Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis.
The Journal of biological chemistry 2001;276(34):31590-5.
2001: Shyamal D Desai; Tsai-Kun Li; A Rodriguez-Bauman; Eric H Rubin; Leroy F Liu
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.
Cancer research 2001;61(15):5926-32.
2001: H Wang; Yong Mao; Nai Zhou; T Hu; T S Hsieh; Leroy F Liu
Atp-bound topoisomerase ii as a target for antitumor drugs.
The Journal of biological chemistry 2001;276(19):15990-5.
2001: H Wang; Yong Mao; A Y Chen; Nai Zhou; Edmond J LaVoie; Leroy F Liu
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.
Biochemistry 2001;40(11):3316-23.
2001: Tsai-Kun Li; Leroy F Liu
Tumor cell death induced by topoisomerase-targeting drugs.
Annual review of pharmacology and toxicology 2001;41():53-77.
2000: M Rangarajan; JS Kim; Sai Peng Sim; Angela Liu; Leroy F Liu; Edmond J LaVoie
Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles.
Bioorganic & medicinal chemistry 2000;8(11):2591-600.
2000: Yong Mao; Shyamal D Desai; Leroy F Liu
SUMO-1 conjugation to human DNA topoisomerase II isozymes.
The Journal of biological chemistry 2000;275(34):26066-73.
2000: Sai Peng Sim; Daniel S Pilch; Leroy F Liu
Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: a potential role of ligand-induced DNA bending at a distal site.
Biochemistry 2000;39(32):9928-34.
2000: Tsai-Kun Li; E Bathory; Edmond J LaVoie; Annankoil R Srinivasan; Wilma K Olson; R R Sauers; Leroy F Liu; Daniel S Pilch
Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.
Biochemistry 2000;39(24):7107-16.
2000: M Rangarajan; JS Kim; S Jin; Sai Peng Sim; Angela Liu; Daniel S Pilch; Leroy F Liu; Edmond J LaVoie
2"-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons.
Bioorganic & medicinal chemistry 2000;8(6):1371-82.
2000: Darshan Makhey; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons.
Bioorganic & medicinal chemistry 2000;8(5):1171-82.
2000: S Jin; JS Kim; Sai Peng Sim; Angela Liu; Daniel S Pilch; Leroy F Liu; Edmond J LaVoie
Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(8):719-23.
2000: Yong Mao; M Sun; Shyamal D Desai; Leroy F Liu
SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4046-51.
2000: M Sun; P Duann; CT Lin; H Zhang; Leroy F Liu
Rapid chromatin reorganization induced by topoisomerase I-mediated DNA damage.
Annals of the New York Academy of Sciences 2000;922():340-2.
2000: Shyamal D Desai; Yong Mao; M Sun; Tsai-Kun Li; J Wu; Leroy F Liu
Ubiquitin, SUMO-1, and UCRP in camptothecin sensitivity and resistance.
Annals of the New York Academy of Sciences 2000;922():306-8.
2000: Leroy F Liu; Shyamal D Desai; Tsai-Kun Li; Yong Mao; M Sun; Sai Peng Sim
Mechanism of action of camptothecin.
Annals of the New York Academy of Sciences 2000;922():1-10.
1999: Yong Mao; C Yu; T S Hsieh; John L. Nitiss; Angela A Liu; H Wang; Leroy F Liu
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.
Biochemistry 1999;38(33):10793-800.
1999: P Duann; M Sun; CT Lin; H Zhang; Leroy F Liu
Plasmid linking number change induced by topoisomerase I-mediated DNA damage.
Nucleic acids research 1999;27(14):2905-11.
1999: Tsai-Kun Li; A Y Chen; C Yu; Yong Mao; H Wang; Leroy F Liu
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.
Genes & development 1999;13(12):1553-60.
1999: P Haluska; Ahamed Saleem; Zeshaan A Rasheed; F Ahmed; E W Su; Leroy F Liu; Eric H Rubin
Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein.
Nucleic acids research 1999;27(12):2538-44.
1999: Yi Lisa Lyu; CT Lin; Leroy F Liu
Inversion/dimerization of plasmids mediated by inverted repeats.
Journal of molecular biology 1999;285(4):1485-501.
1998: Marilyn M Sanders; Angela A Liu; Tsai-Kun Li; H Y Wu; Shyamal D Desai; Yong Mao; Eric H Rubin; Edmond J LaVoie; Darshan Makhey; Leroy F Liu
Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells.
Biochemical pharmacology 1998;56(9):1157-66.
1998: K Neder; Laurence J Marton; Leroy F Liu; Benjamin Frydman
Reaction of beta-lapachone and related naphthoquinones with 2-mercaptoethanol: a biomimetic model of topoisomerase II poisoning by quinones.
Cellular and molecular biology (Noisy-le-Grand, France) 1998;44(3):465-74.
1998: Tsai-Kun Li; Leroy F Liu
Modulation of gyrase-mediated DNA cleavage and cell killing by ATP.
Antimicrobial agents and chemotherapy 1998;42(5):1022-7.
1998: Z Xu; Tsai-Kun Li; J S Kim; Edmond J LaVoie; Kenneth J Breslauer; Leroy F Liu; Daniel S Pilch
DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles.
Biochemistry 1998;37(10):3558-66.
1998: JS Kim; Q Sun; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Quantitative structure-activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents.
Bioorganic & medicinal chemistry 1998;6(2):163-72.
1997: Daniel S Pilch; Z Xu; Q Sun; Edmond J LaVoie; Leroy F Liu; Kenneth J Breslauer
A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13565-70.
1997: J Wu; Leroy F Liu
Processing of topoisomerase I cleavable complexes into DNA damage by transcription.
Nucleic acids research 1997;25(21):4181-6.
1997: Sai Peng Sim; B Gatto; C Yu; Angela A Liu; Tsai-Kun Li; Daniel S Pilch; Edmond J LaVoie; Leroy F Liu
Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar.
Biochemistry 1997;36(43):13285-91.
1997: Daniel S Pilch; C Yu; Darshan Makhey; Edmond J LaVoie; Annankoil R Srinivasan; Wilma K Olson; R R Sauers; Kenneth J Breslauer; N E Geacintov; Leroy F Liu
Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs.
Biochemistry 1997;36(41):12542-53.
1997: Shyamal D Desai; Leroy F Liu; D Vazquez-Abad; Peter D'Arpa
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin.
The Journal of biological chemistry 1997;272(39):24159-64.
1997: JS Kim; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Terbenzimidazoles: influence of 2"-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons.
Journal of medicinal chemistry 1997;40(18):2818-24.
1997: CT Lin; Yi Lisa Lyu; Leroy F Liu
A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats.
Nucleic acids research 1997;25(15):3009-16.
1997: X G Li; P Haluska; Y H Hsiang; A K Bharti; Donald Kufe; Leroy F Liu; Eric H Rubin
Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis.
Biochemical pharmacology 1997;53(7):1019-27.
1997: Benjamin Frydman; Laurence J Marton; J S Sun; K Neder; D T Witiak; Angela A Liu; H M Wang; Yong Mao; H Y Wu; Marilyn M Sanders; Leroy F Liu
Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones.
Cancer research 1997;57(4):620-7.
1996: Leroy F Liu; P Duann; CT Lin; Peter D'Arpa; J Wu
Mechanism of action of camptothecin.
Annals of the New York Academy of Sciences 1996;803():44-9.
1996: B Gatto; Marilyn M Sanders; C Yu; H Y Wu; Darshan Makhey; Edmond J LaVoie; Leroy F Liu
Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne.
Cancer research 1996;56(12):2795-800.
1996: Darshan Makhey; B Gatto; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons.
Bioorganic & medicinal chemistry 1996;4(6):781-91.
1996: Daniel S Pilch; Z Xu; Q Sun; Edmond J LaVoie; Leroy F Liu; N E Geacintov; Kenneth J Breslauer
Characterizing the DNA binding modes of a topoisomerase I-poisoning terbenzimidazole: evidence for both intercalative and minor groove binding properties.
Drug design and discovery 1996;13(3-4):115-33.
1996: JS Kim; Q Sun; B Gatto; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons.
Bioorganic & medicinal chemistry 1996;4(4):621-30.
1996: X Bi; Leroy F Liu
A replicational model for DNA recombination between direct repeats.
Journal of molecular biology 1996;256(5):849-58.
1996: JS Kim; B Gatto; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.
Journal of medicinal chemistry 1996;39(4):992-8.
1996: Eric H Rubin; Tsai-Kun Li; P Duann; Leroy F Liu
Cellular resistance to topoisomerase poisons.
Cancer treatment and research 1996;87():243-60.
1996: X Bi; Leroy F Liu
recA-independent DNA recombination between repetitive sequences: mechanisms and implications.
Progress in nucleic acid research and molecular biology 1996;54():253-92.
1995: Q Sun; B Gatto; C Yu; Angela Liu; Leroy F Liu; Edmond J LaVoie
Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors.
Journal of medicinal chemistry 1995;38(18):3638-44.
1995: X Bi; Yi Lisa Lyu; Leroy F Liu
Specific stimulation of recA-independent plasmid recombination by a DNA sequence at a distance.
Journal of molecular biology 1995;247(5):890-902.
1995: Peter D'Arpa; Leroy F Liu
Cell cycle-specific and transcription-related phosphorylation of mammalian topoisomerase I.
Experimental cell research 1995;217(1):125-31.
1994: S K Meegalla; G J Stevens; C A McQueen; A Y Chen; C Yu; Leroy F Liu; L R Barrows; Edmond J LaVoie
Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.
Journal of medicinal chemistry 1994;37(20):3434-9.
1994: M Drolet; X Bi; Leroy F Liu
Hypernegative supercoiling of the DNA template during transcription elongation in vitro.
The Journal of biological chemistry 1994;269(3):2068-74.
1994: A Y Chen; Leroy F Liu
Design of topoisomerase inhibitors to overcome MDR1-mediated drug resistance.
Advances in pharmacology (San Diego, Calif.) 1994;29B():245-56.
1994: A Y Chen; Leroy F Liu
DNA topoisomerases: essential enzymes and lethal targets.
Annual review of pharmacology and toxicology 1994;34():191-218.
1994: A Y Chen; Leroy F Liu
Mechanisms of resistance to topoisomerase inhibitors.
Cancer treatment and research 1994;73():263-81.
1993: Y P Tsao; A Russo; G Nyamuswa; R Silber; Leroy F Liu
Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system.
Cancer research 1993;53(24):5908-14.
1993: A L Bodley; H C Huang; C Yu; Leroy F Liu
Integration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide).
Molecular and cellular biology 1993;13(10):6190-200.
1993: A Y Chen; C Yu; B Gatto; Leroy F Liu
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8131-5.
1993: A Y Chen; C Yu; A Bodley; L F Peng; Leroy F Liu
A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.
Cancer research 1993;53(6):1332-7.