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Mao-Chin Liu

Research Profile

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Leukemia L1210

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Publications

TOP 3
Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Mao-Chin Liu; Mei-Zhen Luo; Philip G Penketh; Alan C Sartorelli
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
Mary C Long; Paula W Allan; Mei-Zhen Luo; Mao-Chin Liu; Alan C Sartorelli; William B Parker
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of 2',3'-didehydro-2',3'-dideoxy-9-deazaguanosine, a monophosphate prodrug and two analogues, 2',3'-dideoxy-9-deazaguanosine and 2',3'-didehydro-2',3'-dideoxy-9-deazainosine.

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All Publications

2011: Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Mao-Chin Liu; Mei-Zhen Luo; Philip G Penketh; Alan C Sartorelli
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
Journal of medicinal chemistry 2011;54(21):7720-8.
2007: Mary C Long; Paula W Allan; Mei-Zhen Luo; Mao-Chin Liu; Alan C Sartorelli; William B Parker
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
The Journal of antimicrobial chemotherapy 2007;59(1):118-21.
2005: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of 2',3'-didehydro-2',3'-dideoxy-9-deazaguanosine, a monophosphate prodrug and two analogues, 2',3'-dideoxy-9-deazaguanosine and 2',3'-didehydro-2',3'-dideoxy-9-deazainosine.
Nucleosides, nucleotides & nucleic acids 2005;24(2):135-45.
2005: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; Alan C Sartorelli
Synthesis and biological evaluation of 2- and 7-substituted 9-deazaadenosine analogues.
Nucleosides, nucleotides & nucleic acids 2005;24(1):45-62.
2001: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents.
Nucleosides, nucleotides & nucleic acids 2001;20(12):1975-2000.
2001: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of L- and D-configurations of 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine analogues.
Bioorganic & medicinal chemistry letters 2001;11(17):2301-4.
2000: Mei-Zhen Luo; Mao-Chin Liu; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.
Bioorganic & medicinal chemistry letters 2000;10(18):2145-8.
2000: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of 1,3-oxathiolane 5-azapyrimidine, 6-azapyrimidine, and fluorosubstituted 3-deazapyrimidine nucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(3):603-18.
1999: Rick A Finch; Mao-Chin Liu; Ann H Cory; Joseph G Cory; Alan C Sartorelli
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
Advances in enzyme regulation 1999;39():3-12.
1999: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Yung-Chi Cheng; Alan C Sartorelli
Synthesis of 2'-methylene-substituted 5-azapyrimidine, 6-azapyrimidine, and 3-deazaguanine nucleoside analogues as potential antitumor/antiviral agents.
Nucleosides & nucleotides 1999;18(1):55-72.
1997: Germana Rappa; Aurelio Lorico; Mao-Chin Liu; Gary Kruh; Ann H Cory; Joseph G Cory; Alan C Sartorelli
Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase.
Biochemical pharmacology 1997;54(6):649-55.
1996: Mao-Chin Liu; T S Lin; Joseph G Cory; Ann H Cory; Alan C Sartorelli
Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Journal of medicinal chemistry 1996;39(13):2586-93.
1996: T S Lin; M Z Luo; Mao-Chin Liu; Y L Zhu; Elizabeth Gullen; Ginger E Dutschman; Yung-Chi Cheng
Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.
Journal of medicinal chemistry 1996;39(9):1757-9.
1995: Mao-Chin Liu; T S Lin; Philip G Penketh; Alan C Sartorelli
Synthesis and antitumor activity of 4- and 5-substituted derivatives of isoquinoline-1-carboxaldehyde thiosemicarbazone.
Journal of medicinal chemistry 1995;38(21):4234-43.
1995: Mao-Chin Liu; T S Lin; Alan C Sartorelli
Chemical and biological properties of cytotoxic alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.
Progress in medicinal chemistry 1995;32():1-35.
1995: Joseph G Cory; Ann H Cory; Germana Rappa; Aurelio Lorico; Mao-Chin Liu; T S Lin; Alan C Sartorelli
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo.
Advances in enzyme regulation 1995;35():55-68.
1994: Joseph G Cory; Ann H Cory; Germana Rappa; Aurelio Lorico; Mao-Chin Liu; T S Lin; Alan C Sartorelli
Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.
Biochemical pharmacology 1994;48(2):335-44.
1994: T S Lin; M Z Luo; Mao-Chin Liu; S Balakrishna Pai; Ginger E Dutschman; Yung-Chi Cheng
Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Journal of medicinal chemistry 1994;37(6):798-803.
1994: T S Lin; M Z Luo; Mao-Chin Liu; S Balakrishna Pai; Ginger E Dutschman; Yung-Chi Cheng
Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro.
Biochemical pharmacology 1994;47(2):171-4.
1992: Mao-Chin Liu; T S Lin; Alan C Sartorelli
Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Journal of medicinal chemistry 1992;35(20):3672-7.
1992: Yihan Wang; Mao-Chin Liu; T S Lin; Alan C Sartorelli
Synthesis and antitumor activity of 3- and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazones.
Journal of medicinal chemistry 1992;35(20):3667-71.
1991: T S Lin; M Z Luo; Mao-Chin Liu; R H Clarke-Katzenburg; Yung-Chi Cheng; W H Prusoff; W R Mancini; G I Birnbaum; E J Gabe; J Giziewicz
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.
Journal of medicinal chemistry 1991;34(8):2607-15.
1991: T S Lin; J H Yang; Mao-Chin Liu; Z Y Shen; Yung-Chi Cheng; W H Prusoff; G I Birnbaum; J Giziewicz; I Ghazzouli; V Brankovan
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
Journal of medicinal chemistry 1991;34(2):693-701.