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Xiaohong Liu

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Magdeleine Hung; Debi Jin; Stephanie Leavitt; Xiaohong Liu; Anita Niedziela-Majka; Katherine M Brendza; Melanie Wong; Roman Sakowicz
Large-scale functional purification of recombinant HIV-1 capsid.
Anita Niedziela-Majka; Nikos Pagratis; Karen Schwartz; Katherine M Brendza; Jeffrey W Chisholm; Wanchi Fung; Magdeleine Hung; Debi Jin; Latesh Lad; Leanna Lagpacan; Xiaohong Liu; Roman Sakowicz
Lipid-sensing high-throughput ApoA-I assays.
Manuel Tsiang; Yili Xu; Dharmaraj Samuel; Kerim Babaoglu; Romas Geleziunas; Hongyan Guo; Wayne Huang; Magdeleine Hung; Gregg S Jones; Elaine Kan; Eric B Lansdon; Xiaohong Liu; Michael Mitchell; Anita Niedziela-Majka; Nikolai Novikov; Roman Sakowicz
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.

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All Publications

2013: Magdeleine Hung; Debi Jin; Stephanie Leavitt; Xiaohong Liu; Anita Niedziela-Majka; Katherine M Brendza; Melanie Wong; Roman Sakowicz
Large-scale functional purification of recombinant HIV-1 capsid.
PloS one 2013;8(3):e58035.
2012: Anita Niedziela-Majka; Nikos Pagratis; Karen Schwartz; Katherine M Brendza; Jeffrey W Chisholm; Wanchi Fung; Magdeleine Hung; Debi Jin; Latesh Lad; Leanna Lagpacan; Xiaohong Liu; Roman Sakowicz
Lipid-sensing high-throughput ApoA-I assays.
Journal of biomolecular screening 2012;17(8):1050-61.
2012: Manuel Tsiang; Yili Xu; Dharmaraj Samuel; Kerim Babaoglu; Romas Geleziunas; Hongyan Guo; Wayne Huang; Magdeleine Hung; Gregg S Jones; Elaine Kan; Eric B Lansdon; Xiaohong Liu; Michael Mitchell; Anita Niedziela-Majka; Nikolai Novikov; Roman Sakowicz
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
The Journal of biological chemistry 2012;287(25):21189-203.
2012: Christy M Hebner; Magdeleine Hung; John Link; Xiaohong Liu; Michelle Nash; Johan Neyts; Roman Sakowicz; Kyla Bjornson; Steven Bondy; Katherine M Brendza; Wanchi Fung; Bin Han; Maisoun Sulfab; Hengli Tang; James Taylor; Yang Tian; James Trenkle; Randall W Vivian; Weidong Zhong; Uli Schmitz
The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.
PloS one 2012;7(6):e39163.
2011: Magdeleine Hung; Ruth Wang; Xiaohong Liu
Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2011;Chapter 13():Unit13B.6.
2011: Q Khai Huynh; Keith A Koch; David Koditek; Xiaohong Liu; Erinn E Pagratis; Laurie A Castonguay; Christopher B Glascock; Bin Han; Magdeleine Hung; Kelly R Pitts; Brian G Reid; Benjamin A Turner; Sarah J Wise; Nikos Pagratis
Screening and identification of a novel class of TGF-β type 1 receptor kinase inhibitor.
Journal of biomolecular screening 2011;16(7):724-33.
2011: Eric B Lansdon; Qi Liu; Stephanie A Leavitt; Mini Balakrishnan; Jason K Perry; Candra Lancaster-Moyer; Nilima Kutty; Xiaohong Liu; Neil H Squires; William J Watkins; Thorsten A Kirschberg
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Antimicrobial agents and chemotherapy 2011;55(6):2905-15.
2011: Manuel Tsiang; Gregg S Jones; Magdeleine Hung; Dharmaraj Samuel; Nikolai Novikov; Susmith Mukund; Katherine M Brendza; Anita Niedziela-Majka; Debi Jin; Xiaohong Liu; Michael Mitchell; Roman Sakowicz; Romas Geleziunas
Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
Biochemistry 2011;50(10):1567-81.
2010: Eric B Lansdon; Katherine M Brendza; Magdeleine Hung; Ruth Wang; Susmith Mukund; Debi Jin; Gabriel Birkus; Nilima Kutty; Xiaohong Liu
Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.
Journal of medicinal chemistry 2010;53(10):4295-9.
2010: Eric B Lansdon; Dharmaraj Samuel; Leanna Lagpacan; Katherine M Brendza; Kirsten L White; Magdeleine Hung; Xiaohong Liu; Constantine G Boojamra; Richard L Mackman; Tomas Cihlar; Adrian S Ray; Mary E McGrath; Swami Swaminathan
Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.
Journal of molecular biology 2010;397(4):967-78.
2009: Manuel Tsiang; Gregg S Jones; Magdeleine Hung; Susmith Mukund; Bin Han; Xiaohong Liu; Kerim Babaoglu; Eric Lansdon; Xiaowu Chen; Jacob Todd; Terrence Cai; Nikos Pagratis; Roman Sakowicz; Romas Geleziunas
Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.
The Journal of biological chemistry 2009;284(48):33580-99.
2008: Hans Reiser; Jianying Wang; Lee Chong; William J Watkins; Adrian S Ray; Riri Shibata; Gabriel Birkus; Tomas Cihlar; Sylvia Wu; Bei Li; Xiaohong Liu; Ilana N Henne; Grushenka H I Wolfgang; Manoj Desai; Gerald R Rhodes; Arnold Fridland; William A Lee; William Plunkett; David Vail; Douglas Thamm; Robert Jeraj; Daniel B Tumas
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2824-32.
2007: Fang Yu; Gregg S Jones; Magdeleine Hung; Alice H Wagner; Holly L MacArthur; Xiaohong Liu; Stephanie Leavitt; Martin J McDermott; Manuel Tsiang
HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.
Biochemistry 2007;46(10):2899-908.
2007: Gabriel Birkus; Ruth Wang; Xiaohong Liu; Nilima Kutty; Holly MacArthur; Tomas Cihlar; Craig Gibbs; Swami Swaminathan; William Lee; Martin McDermott
Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
Antimicrobial agents and chemotherapy 2007;51(2):543-50.
2006: Tomas Cihlar; Gong-Xin He; Xiaohong Liu; James M Chen; Marcos Hatada; Swami Swaminathan; Martin J McDermott; Zheng-Yu Yang; Andrew S Mulato; Xiaowu Chen; Stephanie A Leavitt; Kirsten M Stray; William A Lee
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
Journal of molecular biology 2006;363(3):635-47.
2006: William J Watkins; James M Chen; Aesop Cho; Lee Chong; Nicole Collins; Maria Fardis; Wei Huang; Magdeleine Hung; Thorsten Kirschberg; William A Lee; Xiaohong Liu; William Thomas; Jie Xu; Ameneh Zeynalzadegan; Jennifer Zhang
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
Bioorganic & medicinal chemistry letters 2006;16(13):3479-83.