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Youhua Liu

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Publications

TOP 3
Lili Zhou; Yingjian Li; Roderick J Tan; Dong Zhou; Youhua Liu
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling.
Roderick J Tan; Youhua Liu
Matrix metalloproteinases in kidney homeostasis and diseases.
Hong Ding; Sha Hao; Weichun He; Fan-fan Hou; Jing Nie; Dong Zhou; Lili Zhou; Youhua Liu
Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis.

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All Publications

2013: Lili Zhou; Yingjian Li; Roderick J Tan; Dong Zhou; Youhua Liu
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling.
Journal of the American Society of Nephrology : JASN 2013;24(5):771-85.
2012: Roderick J Tan; Youhua Liu
Matrix metalloproteinases in kidney homeostasis and diseases.
American journal of physiology. Renal physiology 2012;302(11):F1351-61.
2012: Hong Ding; Sha Hao; Weichun He; Fan-fan Hou; Jing Nie; Dong Zhou; Lili Zhou; Youhua Liu
Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis.
Journal of the American Society of Nephrology : JASN 2012;23(5):801-13.
2012: Yingjian Li; Xiaoyan Wen; Youhua Liu
Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis.
Kidney international 2012;81(9):880-91.
2012: Weichun He; Fan-fan Hou; Yingjian Li; Jing Nie; Roderick J Tan; Dan Wang; Youhua Liu
Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD.
Journal of the American Society of Nephrology : JASN 2012;23(2):294-304.
2011: Youhua Liu
Cellular and molecular mechanisms of renal fibrosis.
Nature reviews. Nephrology 2011;7(12):684-96.
2011: Dan Wang; Chunsun Dai; Yingjian Li; Youhua Liu
Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria.
Kidney international 2011;80(11):1159-69.
2011: Sha Hao; Weichun He; Fan-fan Hou; Yayi Hou; Michael Kahn; Yingjian Li; Hong Ding; Jing Nie; Youhua Liu
Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN 2011;22(9):1642-53.
2011: Chunsun Dai; Xiaoyan Wen; Weichun He; Youhua Liu
Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling.
The Journal of biological chemistry 2011;286(9):7052-9.
2011: Dan Wang; Yingjian Li; Chuanyue Wu; Youhua Liu
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.
PloS one 2011;6(2):e17048.
2011: Weichun He; Young Sun Kang; Chunsun Dai; Youhua Liu
Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury.
Journal of the American Society of Nephrology : JASN 2011;22(1):90-103.
2010: Xiaoyan Wen; Yingjian Li; Youhua Liu
Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligand.
The Journal of biological chemistry 2010;285(39):29981-8.
2010: Sha Hao; Hongmei Shen; Yayi Hou; Wendy M Mars; Youhua Liu
tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.
The American journal of pathology 2010;177(3):1164-75.
2010: Young Sun Kang; Yingjian Li; Chunsun Dai; Lawrence P Kiss; Chuanyue Wu; Youhua Liu
Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.
Kidney international 2010;78(4):363-73.
2010: Chunsun Dai; Moin A Saleem; Lawrence B Holzman; Peter Mathieson; Youhua Liu
Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria.
Kidney international 2010;77(11):962-73.
2010: Youhua Liu
New insights into epithelial-mesenchymal transition in kidney fibrosis.
Journal of the American Society of Nephrology : JASN 2010;21(2):212-22.
2009: Youhua Liu
Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion.
Kidney international 2009;76(11):1125-7.
2009: Xiaoyue Tan; Weichun He; Youhua Liu
Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy.
Kidney international 2009;76(12):1248-57.
2009: Jiang Li; Annette Wilson; Xiang Gao; Ramalinga Kuruba; Youhua Liu; Samuel M Poloyac; Bruce Pitt; Wen Xie; Song Li
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine.
The Journal of pharmacology and experimental therapeutics 2009;331(1):234-43.
2009: Chunsun Dai; Donna B Stolz; Lawrence P Kiss; Satdarshan Pal S. Monga; Lawrence B Holzman; Youhua Liu
Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria.
Journal of the American Society of Nephrology : JASN 2009;20(9):1997-2008.
2009: Yingjian Li; Xiaoyue Tan; Chunsun Dai; Donna B Stolz; Dan Wang; Youhua Liu
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN 2009;20(9):1907-18.
2009: Weichun He; Chunsun Dai; Yingjian Li; Gang Zeng; Satdarshan Pal S. Monga; Youhua Liu
Wnt/beta-catenin signaling promotes renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN 2009;20(4):765-76.
2008: Xiaoyue Tan; Xiaoyan Wen; Youhua Liu
Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling.
Journal of the American Society of Nephrology : JASN 2008;19(9):1741-52.
2008: Myrto Giannopoulou; Chunsun Dai; Xiaoyue Tan; Xiaoyan Wen; George K Michalopoulos; Youhua Liu
Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling.
The American journal of pathology 2008;173(1):30-41.
2008: Kebin Hu; Ling Lin; Xiaoyue Tan; Junwei Yang; Guojun Bu; Wendy M Mars; Youhua Liu
tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis.
Journal of the American Society of Nephrology : JASN 2008;19(3):503-14.
2008: Yingjian Li; Young Sun Kang; Chunsun Dai; Lawrence P Kiss; Xiaoyan Wen; Youhua Liu
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.
The American journal of pathology 2008;172(2):299-308.
2008: Kebin Hu; Wendy M Mars; Youhua Liu
Novel actions of tissue-type plasminogen activator in chronic kidney disease.
Frontiers in bioscience : a journal and virtual library 2008;13():5174-86.
2007: Kebin Hu; Chuanyue Wu; Wendy M Mars; Youhua Liu
Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling.
The Journal of clinical investigation 2007;117(12):3821-32.
2007: Michael T Stang; Michaele J Armstrong; Gregory A Watson; K Y Sung; Youhua Liu; Baoguo Ren; John H Yim
Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells.
Oncogene 2007;26(44):6420-30.
2007: Anette Duensing; Youhua Liu; S A Perdreau; Julia Kleylein-Sohn; Erich A Nigg; Stefan Duensing
Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates.
Oncogene 2007;26(43):6280-8.
2007: Yingjian Li; Chunsun Dai; Chuanyue Wu; Youhua Liu
PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase.
Journal of the American Society of Nephrology : JASN 2007;18(9):2534-43.
2007: Ruoyun Tan; Xianghong Zhang; Junwei Yang; Yingjian Li; Youhua Liu
Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor.
Journal of the American Society of Nephrology : JASN 2007;18(8):2340-9.
2007: Xiaoyue Tan; Yingjian Li; Youhua Liu
Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):491-6.
2007: Yingjian Li; Junwei Yang; Jian-Hua Luo; Shoukat Dedhar; Youhua Liu
Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.
Journal of the American Society of Nephrology : JASN 2007;18(2):449-60.
2007: Anette Duensing; Youhua Liu; Nicole Spardy; K Bartoli; Michelle Tseng; J-A Kwon; X Teng; Stefan Duensing
RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication.
Oncogene 2007;26(2):215-23.
2006: Xiaoyue Tan; Yingjian Li; Youhua Liu
Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.
Journal of the American Society of Nephrology : JASN 2006;17(12):3382-93.
2006: Udayan Apte; Gang Zeng; Peggy Muller; Xinping Tan; Amanda Micsenyi; Benjamin Cieply; Chunsun Dai; Youhua Liu; Klaus kaestner; Satdarshan Pal S. Monga
Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice.
Hepatology (Baltimore, Md.) 2006;44(4):992-1002.
2006: Ruoyun Tan; Jinglan Zhang; Xiaoyue Tan; Xianghong Zhang; Junwei Yang; Youhua Liu
Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation.
Journal of the American Society of Nephrology : JASN 2006;17(10):2781-91.
2006: Chunsun Dai; Donna B Stolz; Sheldon Bastacky; René St-Arnaud; Chuanyue Wu; Shoukat Dedhar; Youhua Liu
Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling.
Journal of the American Society of Nephrology : JASN 2006;17(8):2164-75.
2006: Youhua Liu; Junwei Yang
Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?
Kidney international 2006;70(2):238-40.
2006: Youhua Liu
Rapamycin and chronic kidney disease: beyond the inhibition of inflammation.
Kidney international 2006;69(11):1925-7.
2006: Anette Duensing; Youhua Liu; Michelle Tseng; Marcos Malumbres; Mariano Barbacid; Stefan Duensing
Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication.
Oncogene 2006;25(20):2943-9.
2006: Jing-Lin Xia; Chunsun Dai; George K Michalopoulos; Youhua Liu
Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation.
The American journal of pathology 2006;168(5):1500-12.
2006: Kebin Hu; Junwei Yang; Sakae Tanaka; Steven L Gonias; Wendy M Mars; Youhua Liu
Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.
The Journal of biological chemistry 2006;281(4):2120-7.
2006: Youhua Liu
Renal fibrosis: new insights into the pathogenesis and therapeutics.
Kidney international 2006;69(2):213-7.
2006: Yingjian Li; Xiaoyan Wen; Bradley C Spataro; Kebin Hu; Chunsun Dai; Youhua Liu
hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists.
Journal of the American Society of Nephrology : JASN 2006;17(1):54-65.
2005: Xiaoyan Wen; Yingjian Li; Kebin Hu; Chunsun Dai; Youhua Liu
Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.
The American journal of pathology 2005;167(4):947-57.
2005: Yingjian Li; Bradley C Spataro; Junwei Yang; Chunsun Dai; Youhua Liu
1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression.
Kidney international 2005;68(4):1500-10.
2005: Chunsun Dai; Chang-Goo Huh; Snorri S Thorgeirsson; Youhua Liu
Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance.
The American journal of pathology 2005;167(2):429-36.
2005: Daniela Volonte; Youhua Liu; Ferruccio Galbiati
The modulation of caveolin-1 expression controls satellite cell activation during muscle repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):237-9.
2005: Junwei Yang; Chunsun Dai; Youhua Liu
A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition.
Journal of the American Society of Nephrology : JASN 2005;16(1):68-78.
2005: Xianghong Zhang; Junwei Yang; Yingjian Li; Youhua Liu
Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells.
American journal of physiology. Renal physiology 2005;288(1):F16-26.
2004: Chang Han; Anthony J Demetris; Youhua Liu; James H Shelhamer; Tong Wu
Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. A novel mechanism for subversion of TGF-beta-induced mitoinhibition.
The Journal of biological chemistry 2004;279(43):44344-54.
2004: Chunsun Dai; Junwei Yang; Sheldon Bastacky; Jinglin Xia; Yingjian Li; Youhua Liu
Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in mice.
Journal of the American Society of Nephrology : JASN 2004;15(10):2637-47.
2004: Youhua Liu
Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action.
American journal of physiology. Renal physiology 2004;287(1):F7-16.
2004: Chunsun Dai; Youhua Liu
Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF.
Journal of the American Society of Nephrology : JASN 2004;15(6):1402-12.
2004: Youhua Liu
Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.
Journal of the American Society of Nephrology : JASN 2004;15(1):1-12.
2003: Junwei Yang; Xianghong Zhang; Yingjian Li; Youhua Liu
Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling.
Journal of the American Society of Nephrology : JASN 2003;14(12):3167-77.
2003: Yingjian Li; Junwei Yang; Chunsun Dai; Chuanyue Wu; Youhua Liu
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.
The Journal of clinical investigation 2003;112(4):503-16.
2003: Junwei Yang; Chunsun Dai; Youhua Liu
Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction.
The American journal of pathology 2003;163(2):621-32.
2003: Chunsun Dai; Yingjian Li; Junwei Yang; Youhua Liu
Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice.
The Journal of biological chemistry 2003;278(29):27080-7.
2003: Xianghong Zhang; Youhua Liu
Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.
American journal of physiology. Renal physiology 2003;284(6):F1216-25.
2003: Chunsun Dai; Junwei Yang; Youhua Liu
Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling.
The Journal of biological chemistry 2003;278(14):12537-45.
2003: Junwei Yang; Youhua Liu
Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy.
American journal of physiology. Renal physiology 2003;284(2):F349-57.
2003: Xianghong Zhang; Yingjian Li; Chunsun Dai; Junwei Yang; Peter Mundel; Youhua Liu
Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.
American journal of physiology. Renal physiology 2003;284(1):F82-94.
2002: Junwei Yang; Ryan W Shultz; Wendy M Mars; Rodney E Wegner; Yingjian Li; Chunsun Dai; Kari Nejak; Youhua Liu
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.
The Journal of clinical investigation 2002;110(10):1525-38.
2002: Junwei Yang; Chunsun Dai; Youhua Liu
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice.
Journal of the American Society of Nephrology : JASN 2002;13(10):2464-77.
2002: Chunsun Dai; Junwei Yang; Youhua Liu
Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice.
Journal of the American Society of Nephrology : JASN 2002;13(2):411-22.
2002: Youhua Liu
Hepatocyte growth factor and the kidney.
Current opinion in nephrology and hypertension 2002;11(1):23-30.
2002: Junwei Yang; Youhua Liu
Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN 2002;13(1):96-107.
2001: Junwei Yang; Chunsun Dai; Youhua Liu
Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice.
Gene therapy 2001;8(19):1470-9.
2001: Junwei Yang; Youhua Liu
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis.
The American journal of pathology 2001;159(4):1465-75.
2001: Junwei Yang; S Chen; Leaf Huang; George K Michalopoulos; Youhua Liu
Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth.
Hepatology (Baltimore, Md.) 2001;33(4):848-59.
1998: Aaron W Bell; JG Jiang; Q Chen; Youhua Liu; Rasa Zarnegar
The upstream regulatory regions of the hepatocyte growth factor gene promoter are essential for its expression in transgenic mice.
The Journal of biological chemistry 1998;273(12):6900-8.
1997: JG Jiang; Aaron Bell; Youhua Liu; Rasa Zarnegar
Transcriptional regulation of the hepatocyte growth factor gene by the nuclear receptors chicken ovalbumin upstream promoter transcription factor and estrogen receptor.
The Journal of biological chemistry 1997;272(7):3928-34.
1994: Youhua Liu; A B Beedle; L Lin; A W Bell; Rasa Zarnegar
Identification of a cell-type-specific transcriptional repressor in the promoter region of the mouse hepatocyte growth factor gene.
Molecular and cellular biology 1994;14(11):7046-58.
1994: Youhua Liu; L Lin; Rasa Zarnegar
Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary.
Molecular and cellular endocrinology 1994;104(2):173-81.
1994: Youhua Liu; A W Bell; George K Michalopoulos; Rasa Zarnegar
The mouse hepatocyte growth factor-encoding gene: structural organization and evolutionary conservation.
Gene 1994;144(2):179-87.
1994: A Moghul; L Lin; A Beedle; Amal Kanbour-Shakir; Marie C DeFrances; Youhua Liu; Rasa Zarnegar
Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript.
Oncogene 1994;9(7):2045-52.
1994: Youhua Liu; George K Michalopoulos; Rasa Zarnegar
Structural and functional characterization of the mouse hepatocyte growth factor gene promoter.
The Journal of biological chemistry 1994;269(6):4152-60.
1993: Youhua Liu; George K Michalopoulos; Rasa Zarnegar
Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor.
Biochimica et biophysica acta 1993;1216(2):299-303.