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Miguel Llinás

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Nuclear Magnetic Resonance, Biomolecular

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Publications

TOP 3
Martin T Christen; Pascal Frank; Johann Schaller; Miguel Llinás
Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape.
Guillermo A Bermejo; Miguel Llinás
Structure-oriented methods for protein NMR data analysis.
Hyung J Kim; Moo Young Choi; Hyung J Kim; Miguel Llinás
Conformational dynamics and ligand binding in the multi-domain protein PDC109.

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All Publications

2010: Martin T Christen; Pascal Frank; Johann Schaller; Miguel Llinás
Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape.
Biochemistry 2010;49(33):7131-50.
2010: Guillermo A Bermejo; Miguel Llinás
Structure-oriented methods for protein NMR data analysis.
Progress in nuclear magnetic resonance spectroscopy 2010;56(4):311-28.
2010: Hyung J Kim; Moo Young Choi; Hyung J Kim; Miguel Llinás
Conformational dynamics and ligand binding in the multi-domain protein PDC109.
PloS one 2010;5(2):e9180.
2009: Marcos D Battistel; Alexander Grishaev; Seong Soo A An; Francis J Castellino; Miguel Llinás
Solution structure and functional characterization of human plasminogen kringle 5.
Biochemistry 2009;48(43):10208-19.
2008: Olga A Ozhogina; Alexander Grishaev; Emile L Bominaar; László Patthy; Mária Trexler; Miguel Llinás
NMR solution structure of the neurotrypsin Kringle domain.
Biochemistry 2008;47(47):12290-8.
2008: Guillermo A Bermejo; Miguel Llinás
Deuterated protein folds obtained directly from unassigned nuclear overhauser effect data.
Journal of the American Chemical Society 2008;130(12):3797-805.
2005: Alexander Grishaev; C A Steren; B Wu; A Pineda-Lucena; C Arrowsmith; Miguel Llinás
ABACUS, a direct method for protein NMR structure computation via assembly of fragments.
Proteins 2005;61(1):36-43.
2005: Alexander Grishaev; Miguel Llinás
Protein structure elucidation from minimal NMR data: the CLOUDS approach.
Methods in enzymology 2005;394():261-95.
2004: Marion Gehrmann; Justin T Douglas; László Bányai; Hedvig Tordai; László Patthy; Miguel Llinás
Modular autonomy, ligand specificity, and functional cooperativity of the three in-tandem fibronectin type II repeats from human matrix metalloproteinase 2.
The Journal of biological chemistry 2004;279(45):46921-9.
2004: Alexander Grishaev; Miguel Llinás
BACUS: A Bayesian protocol for the identification of protein NOESY spectra via unassigned spin systems.
Journal of biomolecular NMR 2004;28(1):1-10.
2003: Mária Trexler; Klára Briknarová; Marion Gehrmann; Miguel Llinás; László Patthy
Peptide ligands for the fibronectin type II modules of matrix metalloproteinase 2 (MMP-2).
The Journal of biological chemistry 2003;278(14):12241-6.
2003: pascal frank; Justin T Douglas; Michael Locher; Miguel Llinás; Johann Schaller
Structural/functional characterization of the alpha 2-plasmin inhibitor C-terminal peptide.
Biochemistry 2003;42(4):1078-85.
2002: Alexander Grishaev; Miguel Llinás
Sorting signals from protein NMR spectra: SPI, a Bayesian protocol for uncovering spin systems.
Journal of biomolecular NMR 2002;24(3):203-13.
2002: Alexander Grishaev; Miguel Llinás
CLOUDS, a protocol for deriving a molecular proton density via NMR.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6707-12.
2002: Justin T Douglas; Priska D von Haller; Marion Gehrmann; Miguel Llinás; Johann Schaller
The two-domain NK1 fragment of plasminogen: folding, ligand binding, and thermal stability profile.
Biochemistry 2002;41(10):3302-10.
2002: Marion Gehrmann; Klára Briknarová; László Bányai; László Patthy; Miguel Llinás
The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.
Biological chemistry 2002;383(1):137-48.
2001: O A Ozhogina; Mária Trexler; László Bányai; Miguel Llinás; László Patthy
Origin of fibronectin type II (FN2) modules: structural analyses of distantly-related members of the kringle family idey the kringle domain of neurotrypsin as a potential link between FN2 domains and kringles.
Protein science : a publication of the Protein Society 2001;10(10):2114-22.
2001: Klára Briknarová; Marion Gehrmann; László Bányai; Hedvig Tordai; László Patthy; Miguel Llinás
Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct.
The Journal of biological chemistry 2001;276(29):27613-21.
2001: V O Lewis; Michael S O'Reilly; Marion Gehrmann; Miguel Llinás; Johann Schaller; Lawrence Weissbach
Inhibition of tumor growth by plasminogen-related protein-B.
Anticancer research 2001;21(4A):2287-91.
2001: Chih-Kao Hu; Miguel Llinás; K E Agner; Lars Orning; Kjell S Sakariassen; Peter M Fischer
Synthesis, biological activity, and solution structures of a cyclic dodecapeptide from the EGF-2 domain of blood coagulation factor VII.
The journal of peptide research : official journal of the American Peptide Society 2001;57(6):462-72.
2001: Klára Briknarová; Shinichi Takayama; Lars Brive; Marnie Havert Fusco; Deborah A Knee; J Velasco; Sachiko Homma; Edelmira Cabezas; J Stuart; David W Hoyt; Arnold C Satterthwait; Miguel Llinás; John C Reed; Kathryn R Ely
Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein.
Nature structural biology 2001;8(4):349-52.
1999: Dorothee Marti; Johann Schaller; Miguel Llinás
Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains.
Biochemistry 1999;38(48):15741-55.
1999: Klára Briknarová; Alexander Grishaev; László Bányai; Hedvig Tordai; László Patthy; Miguel Llinás
The second type II module from human matrix metalloproteinase 2: structure, function and dynamics.
Structure (London, England : 1993) 1999;7(10):1235-45.
1999: V O Lewis; Marion Gehrmann; Lawrence Weissbach; J E Hyman; A Rielly; D G Jones; Miguel Llinás; Johann Schaller
Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins.
European journal of biochemistry / FEBS 1999;259(3):618-25.
1999: Leonid Medved; Molly Migliorini; Irina Mikhailenko; L G Barrientos; Miguel Llinás; Dudley K Strickland
Domain organization of the 39-kDa receptor-associated protein.
The Journal of biological chemistry 1999;274(2):717-27.
1998: W R Ji; FJ Castellino; Y Chang; M E Deford; H Gray; X Villarreal; M E Kondri; Dorothee Marti; Miguel Llinás; Johann Schaller; RA Kramer; Pamela A Trail
Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(15):1731-8.
1998: W R Ji; L G Barrientos; Miguel Llinás; H Gray; X Villarreal; M E DeFord; FJ Castellino; RA Kramer; Pamela A Trail
Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis.
Biochemical and biophysical research communications 1998;247(2):414-9.
1997: Dorothee Marti; Chih-Kao Hu; SS An; Priska D von Haller; Johann Schaller; Miguel Llinás
Ligand preferences of kringle 2 and homologous domains of human plasminogen: canvassing weak, intermediate, and high-affinity binding sites by 1H-NMR.
Biochemistry 1997;36(39):11591-604.
1997: Yihai Cao; A Chen; SS An; R W Ji; D Davidson; Miguel Llinás
Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth.
The Journal of biological chemistry 1997;272(36):22924-8.
1996: Yihai Cao; R W Ji; D Davidson; Johann Schaller; Dorothee Marti; S Söhndel; S G McCance; Michael S O'Reilly; Miguel Llinás; Judah Folkman
Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.
The Journal of biological chemistry 1996;271(46):29461-7.
1996: S Söhndel; C K Hu; Dorothee Marti; M Affolter; Johann Schaller; Miguel Llinás; E E Rickli
Recombinant gene expression and 1H NMR characteristics of the kringle (2 + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains.
Biochemistry 1996;35(7):2357-64.
1995: V Ramesh; N Rajan; R A Laursen; Miguel Llinás
Plasminogen kringle 4 binds the heptapeptide fragment 44-50 of the plasminogen N-terminal peptide.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(3):207-18.
1995: I J Byeon; Robert F Kelley; Michael Mulkerrin; SS An; Miguel Llinás
Ligand binding to the tissue-type plasminogen activator kringle 2 domain: structural characterization by 1H-NMR.
Biochemistry 1995;34(9):2739-50.
1994: C K Hu; U Kohnert; O Wilhelm; S Fischer; Miguel Llinás
Tissue-type plasminogen activator domain-deletion mutant BM 06.022: modular stability, inhibitor binding, and activation cleavage.
Biochemistry 1994;33(39):11760-6.
1994: M R Rejante; Miguel Llinás
Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1.
European journal of biochemistry / FEBS 1994;221(3):939-49.
1994: M R Rejante; Miguel Llinás
1H-NMR assignments and secondary structure of human plasminogen kringle 1.
European journal of biochemistry / FEBS 1994;221(3):927-37.
1994: X Li; A M Bokman; Miguel Llinás; R A G Smith; Christopher M Dobson
Solution structure of the kringle domain from urokinase-type plasminogen activator.
Journal of molecular biology 1994;235(5):1548-59.
1993: A M Bokman; J Jiménez-Barbero; Miguel Llinás
1H NMR characterization of the urokinase kringle module. Structural, but not functional, relatedness to homologous domains.
The Journal of biological chemistry 1993;268(19):13858-68.
1992: SS An; J Jiménez-Barbero; T E Petersen; Miguel Llinás
The two polypeptide chains in fibronectin are joined in antiparallel fashion: NMR structural characterization.
Biochemistry 1992;31(41):9927-33.
1992: Ross W Stephens; A M Bokman; H T Myöhänen; T Reisberg; H Tapiovaara; N Pedersen; J Grøndahl-Hansen; Miguel Llinás; Antti Vaheri
Heparin binding to the urokinase kringle domain.
Biochemistry 1992;31(33):7572-9.
1992: K L Constantine; Shelesa A Brew; Kenneth C Ingham; Miguel Llinás
1H-n.m.r. studies of the fibronectin 13 kDa collagen-binding fragment. Evidence for autonomous conserved type I and type II domain folds.
The Biochemical journal 1992;283 ( Pt 1)():247-54.
1992: K L Constantine; M Madrid; László Bányai; M Trexler; László Patthy; Miguel Llinás
Refined solution structure and ligand-binding properties of PDC-109 domain b. A collagen-binding type II domain.
Journal of molecular biology 1992;223(1):281-98.
1991: I J Byeon; Miguel Llinás
Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.
Journal of molecular biology 1991;222(4):1035-51.
1991: M R Rejante; I J Byeon; Miguel Llinás
Ligand specificity of human plasminogen kringle 4.
Biochemistry 1991;30(46):11081-92.
1991: I J Byeon; Robert F Kelley; Miguel Llinás
Kringle-2 domain of the tissue-type plasminogen activator. 1H-NMR assignments and secondary structure.
European journal of biochemistry / FEBS 1991;197(1):155-65.
1991: K L Constantine; V Ramesh; László Bányai; M Trexler; László Patthy; Miguel Llinás
Sequence-specific 1H NMR assignments and structural characterization of bovine seminal fluid protein PDC-109 domain b.
Biochemistry 1991;30(6):1663-72.
1990: T Thewes; K Constantine; I J Byeon; Miguel Llinás
Ligand interactions with the kringle 5 domain of plasminogen. A study by 1H NMR spectroscopy.
The Journal of biological chemistry 1990;265(7):3906-15.
1990: K L Constantine; A De Marco; M Madrid; C L Brooks; Miguel Llinás
The solution conformations of ferrichrome and deferriferrichrome determined by 1H-NMR spectroscopy and computational modeling.
Biopolymers 1990;30(3-4):239-56.
1989: I J Byeon; Robert F Kelley; Miguel Llinás
1H NMR structural characterization of a recombinant kringle 2 domain from human tissue-type plasminogen activator.
Biochemistry 1989;28(24):9350-60.
1989: A M Petros; V Ramesh; Miguel Llinás
1H NMR studies of aliphatic ligand binding to human plasminogen kringle 4.
Biochemistry 1989;28(3):1368-76.
1989: Anne M Mulichak; C H Park; Alexander Tulinsky; A M Petros; Miguel Llinás
Human plasminogen kringle 4. Crystallization and preliminary diffraction data of two different crystal forms.
The Journal of biological chemistry 1989;264(4):1922-3.
1989: A De Marco; A M Petros; Miguel Llinás; R Kaptein; R Boelens
Ligand-binding effects on the kringle 4 domain from human plasminogen: a study by laser photo-CIDNP 1H-NMR spectroscopy.
Biochimica et biophysica acta 1989;994(2):121-37.
1988: T Thewes; V Ramesh; E L Simplaceanu; Miguel Llinás
Analysis of the aromatic 1H-NMR spectrum of the kringle 5 domain from human plasminogen. Evidence for a conserved kringle fold.
European journal of biochemistry / FEBS 1988;175(2):237-49.
1988: A M Petros; M Gyenes; László Patthy; Miguel Llinás
Analysis of the aromatic 1H NMR spectrum of chicken plasminogen kringle 4.
Archives of biochemistry and biophysics 1988;264(1):192-202.
1988: A M Petros; M Gyenes; László Patthy; Miguel Llinás
Analysis of the aliphatic 1H-NMR spectrum of plasminogen kringle 4. A comparative study of human, porcine, bovine and chicken homologs.
European journal of biochemistry / FEBS 1988;170(3):549-63.
1988: Alexander Tulinsky; C H Park; B Mao; Miguel Llinás
Lysine/fibrin binding sites of kringles modeled after the structure of kringle 1 of prothrombin.
Proteins 1988;3(2):85-96.
1987: V Ramesh; A M Petros; Miguel Llinás; A Tulinsky; C H Park
Proton magnetic resonance study of lysine-binding to the kringle 4 domain of human plasminogen. The structure of the binding site.
Journal of molecular biology 1987;198(3):481-98.
1987: A Motta; R A Laursen; Miguel Llinás; A Tulinsky; C H Park
Complete assignment of the aromatic proton magnetic resonance spectrum of the kringle 1 domain from human plasminogen: structure of the ligand-binding site.
Biochemistry 1987;26(13):3827-36.
1987: T Thewes; V Ramesh; E L Simplaceanu; Miguel Llinás
Isolation, purification and 1H-NMR characterization of a kringle 5 domain fragment from human plasminogen.
Biochimica et biophysica acta 1987;912(2):254-69.
1987: A De Marco; A M Petros; R A Laursen; Miguel Llinás
Analysis of ligand-binding to the kringle 4 fragment from human plasminogen.
European biophysics journal : EBJ 1987;14(6):359-68.
1986: A Motta; R A Laursen; Miguel Llinás
Characterization of the low-field proton magnetic resonance spectrum of plasminogen kringle 4 via selective Overhauser experiments in 1H2O.
Biochemistry 1986;25(24):7924-31.
1986: A De Marco; Lucia Zetta; A M Petros; Miguel Llinás; R Boelens; R Kaptein
Kringle 4 from human plasminogen: a proton magnetic resonance study via two-dimensional photochemically induced dynamic nuclear polarization spectroscopy.
Biochemistry 1986;25(24):7918-23.
1986: A Motta; R A Laursen; N Rajan; Miguel Llinás
Proton magnetic resonance study of kringle 1 from human plasminogen. Insights into the domain structure.
The Journal of biological chemistry 1986;261(29):13684-92.
1986: V Ramesh; M Gyenes; László Patthy; Miguel Llinás
The aromatic 1H-NMR spectrum of plasminogen kringle 4. A comparative study of human, porcine and bovine homologs.
European journal of biochemistry / FEBS 1986;159(3):581-95.
1985: A De Marco; A Motta; Miguel Llinás; R A Laursen
Macro- and micro-stabilities of the kringle 4 domain from plasminogen. The effect of ligand binding.
Biophysical journal 1985;48(3):411-22.
1985: A De Marco; R A Laursen; Miguel Llinás
Proton Overhauser experiments on kringle 4 from human plasminogen. Implications for the structure of the kringles' hydrophobic core.
Biochimica et biophysica acta 1985;827(3):369-80.
1985: A De Marco; N D Pluck; László Bányai; M Trexler; R A Laursen; László Patthy; Miguel Llinás; R J Williams
Analysis and identification of aromatic signals in the proton magnetic resonance spectrum of the kringle 4 fragment from human plasminogen.
Biochemistry 1985;24(3):748-53.
1982: A De Marco; S M Hochschwender; R A Laursen; Miguel Llinás
Human plasminogen. Proton NMR studies on kringle 1.
The Journal of biological chemistry 1982;257(21):12716-21.