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Stephen Lloyd

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Amit Ketkar; R Stephen Lloyd; Leena Maddukuri; Kinrin Yamanaka; Maroof K Zafar; Surajit Banerjee; Jeong-Yun Choi; Martin Egli; Robert L Eoff
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.
Parvathi Chary; William A Beard; Samuel H Wilson; R Stephen Lloyd
DNA polymerase β gap-filling translesion DNA synthesis.
Plamen P Christov; F Peter Guengerich; R Stephen Lloyd; Kei-ichi Takata; Richard D Wood; Kinrin Yamanaka; Jeong-Yun Choi; Carmelo J Rizzo
Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases.

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All Publications

2013: Amit Ketkar; R Stephen Lloyd; Leena Maddukuri; Kinrin Yamanaka; Maroof K Zafar; Surajit Banerjee; Jeong-Yun Choi; Martin Egli; Robert L Eoff
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.
Chemical research in toxicology 2013;26(2):221-32.
2012: Parvathi Chary; William A Beard; Samuel H Wilson; R Stephen Lloyd
DNA polymerase β gap-filling translesion DNA synthesis.
Chemical research in toxicology 2012;25(12):2744-54.
2012: Plamen P Christov; F Peter Guengerich; R Stephen Lloyd; Kei-ichi Takata; Richard D Wood; Kinrin Yamanaka; Jeong-Yun Choi; Carmelo J Rizzo
Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases.
Chemical research in toxicology 2012;25(8):1652-61.
2012: Harini Sampath; Amanda K McCullough; R Stephen Lloyd
Regulation of DNA glycosylases and their role in limiting disease.
Free radical research 2012;46(4):460-78.
2012: Alex R Klug; R Stephen Lloyd; Michael Harbut; Irina G Minko
Replication bypass of N2-deoxyguanosine interstrand cross-links by human DNA polymerases η and ι.
Chemical research in toxicology 2012;25(3):755-62.
2012: Harini Sampath; Vladimir Vartanian; Yusaku Nakabeppu; M Rick Rollins; Kunihiko Sakumi; R Stephen Lloyd
8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction.
PloS one 2012;7(12):e51697.
2011: Olga P Ryabinina; Michael R Lasarev; Amanda K McCullough; Irina G Minko; R Stephen Lloyd
Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase.
DNA repair 2011;10(10):1014-22.
2011: Hai Huang; Albena Kozekova; R Stephen Lloyd; Amanda K McCullough; Carmelo J Rizzo; Markus Voehler; Hao Wang; Michael P Stone
γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.
Chemical research in toxicology 2011;24(7):1123-33.
2011: Jodi L Johnson; Brian C Lowell; Olga P Ryabinina; R Stephen Lloyd; Amanda K McCullough
TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage.
The Journal of investigative dermatology 2011;131(3):753-61.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Carmelo J Rizzo; Amanda K McCullough; R Stephen Lloyd; Michael P Stone
Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage.
Biochemistry 2010;49(29):6155-64.
2010: Anuradha Kumari; Irina G Minko; Rebecca L Smith; R Stephen Lloyd; Amanda K McCullough
Modulation of UvrD helicase activity by covalent DNA-protein cross-links.
The Journal of biological chemistry 2010;285(28):21313-22.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
DNA cross-link induced by trans-4-hydroxynonenal.
Environmental and molecular mutagenesis 2010;51(6):625-34.
2010: Kinrin Yamanaka; Irina G Minko; Kei-ichi Takata; Alexander Kolbanovskiy; Ivan D Kozekov; Richard D Wood; Carmelo J Rizzo; R Stephen Lloyd
Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links.
Chemical research in toxicology 2010;23(3):689-95.
2010: Pawel Jaruga; Yan Xiao; Vladimir Vartanian; R Stephen Lloyd; Miral Dizdaroglu
Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines.
Biochemistry 2010;49(6):1053-5.
2009: Hiromi Mori; Rika Ouchida; Atsushi Hijikata; Hiroshi Kitamura; Osamu Ohara; Yingqian Li; Xiang Gao; Akira Yasui; R Stephen Lloyd; Ji-Yang Wang
Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion.
DNA repair 2009;8(11):1328-32.
2009: Michael K Chan; Maria T Ocampo-Hafalla; Vladimir Vartanian; Pawel Jaruga; Guldal KIRKALI; Karen L Koenig; Stuart Brown; R Stephen Lloyd; Miral Dizdaroglu; George W Teebor
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
DNA repair 2009;8(7):786-94.
2009: Irina G Minko; Ivan D Kozekov; Thomas M Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.
Chemical research in toxicology 2009;22(5):759-78.
2009: Hai Huang; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N(2)-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA.
Chemical research in toxicology 2009;22(1):187-200.
2008: Hai Huang; Hao Wang; Nan Qi; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence.
Biochemistry 2008;47(44):11457-72.
2008: Anuradha Kumari; Irina G Minko; Michael Harbut; Steven E Finkel; Myron F Goodman; R Stephen Lloyd
Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV.
The Journal of biological chemistry 2008;283(41):27433-7.
2008: Irina G Minko; Kinrin Yamanaka; Ivan D Kozekov; Albena Kozekova; Chiara Indiani; Michael E O'Donnell; QINGFEI JIANG; Myron F Goodman; Carmelo J Rizzo; R Stephen Lloyd
Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family.
Chemical research in toxicology 2008;21(10):1983-90.
2008: Michael P Stone; Young-Jin Cho; Hai Huang; Hye-Young Kim; Ivan D Kozekov; Albena Kozekova; Hao Wang; Irina G Minko; R Stephen Lloyd; Thomas Harris; Carmelo J Rizzo
Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
Accounts of chemical research 2008;41(7):793-804.
2008: Irina G Minko; Michael Harbut; Ivan D Kozekov; Albena Kozekova; Petra Jakobs; Susan B Olson; Robb Moses; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd
Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links.
The Journal of biological chemistry 2008;283(25):17075-82.
2008: Irina G Minko; Ivan D Kozekov; Albena Kozekova; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd
Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts.
Mutation research 2008;637(1-2):161-72.
2007: Priscilla H Fernandes; R Stephen Lloyd
Mutagenic bypass of the butadiene-derived 2'-deoxyuridine adducts by polymerases eta and zeta.
Mutation research 2007;625(1-2):40-9.
2007: Laura Roy; Pawel Jaruga; Thomas G Wood; Amanda K McCullough; Miral Dizdaroglu; R Stephen Lloyd
Human polymorphic variants of the NEIL1 DNA glycosylase.
The Journal of biological chemistry 2007;282(21):15790-8.
2007: Jeffrey K Wickliffe; Stacy M Herring; Lance Hallberg; Lori A Galbert; Oscar E Masters; Marinel M Ammenheuser; Jingwu Xie; Errol C Friedberg; R Stephen Lloyd; Sherif Z Abdel-Rahman; Jonathan B Ward
Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene.
Chemico-biological interactions 2007;166(1-3):226-31.
2007: Wen Xu; W Keither Merritt; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.
Chemical research in toxicology 2007;20(2):187-98.
2006: Randall K Walker; Amanda K McCullough; R Stephen Lloyd
Uncoupling of nucleotide flipping and DNA bending by the t4 pyrimidine dimer DNA glycosylase.
Biochemistry 2006;45(47):14192-200.
2006: Gali Golan; Dmitry O Zharkov; Arthur P Grollman; ML Dodson; Amanda K McCullough; R Stephen Lloyd; Gil Shoham
Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA.
Journal of molecular biology 2006;362(2):241-58.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Albena Kozekova; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(8):1019-29.
2006: Priscilla H Fernandes; Linda C Hackfeld; Ivan D Kozekov; Richard P Hodge; R Stephen Lloyd
Synthesis and mutagenesis of the butadiene-derived N3 2'-deoxyuridine adducts.
Chemical research in toxicology 2006;19(7):968-76.
2006: Michael Harbut; Michael G Meador; M L Dodson; R Stephen Lloyd
Modulation of the turnover of formamidopyrimidine DNA glycosylase.
Biochemistry 2006;45(23):7341-6.
2006: Vladimir Vartanian; Brian Lowell; Irina G Minko; Thomas G Wood; Jeffrey D Ceci; Shakeeta George; Scott W Ballinger; Christopher L Corless; Amanda K McCullough; R Stephen Lloyd
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1864-9.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(2):195-208.
2006: William T Wolfle; Robert E Johnson; Irina G Minko; R Stephen Lloyd; Satya Prakash; Louise Prakash
Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases iota and kappa.
Molecular and cellular biology 2006;26(1):381-6.
2006: Jeffrey K Wickliffe; L A Galbert; Marinel M Ammenheuser; S M Herring; Jingwu Xie; O E Masters; Errol C Friedberg; R Stephen Lloyd; Jonathan B Ward
3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice.
Environmental and molecular mutagenesis 2006;47(1):67-70.
2005: Young-Jin Cho; Hye-Young Kim; Hai Huang; Alvira Slutsky; Irina G Minko; Hao Wang; Lubomir V Nechev; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Jaison Jacob; Markus Voehler; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.
Journal of the American Chemical Society 2005;127(50):17686-96.
2005: Manorama Kanuri; Lubomir V Nechev; Sarah E Kiehna; Pamela J Tamura; Constance M Harris; Thomas Harris; R Stephen Lloyd
Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks.
DNA repair 2005;4(12):1374-80.
2005: Ana M Sanchez; Ivan D Kozekov; Thomas Harris; R Stephen Lloyd
Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts.
Chemical research in toxicology 2005;18(11):1683-90.
2005: William T Wolfle; Robert E Johnson; Irina G Minko; R Stephen Lloyd; Satya Prakash; Louise Prakash
Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA.
Molecular and cellular biology 2005;25(19):8748-54.
2005: R Stephen Lloyd
Investigations of pyrimidine dimer glycosylases--a paradigm for DNA base excision repair enzymology.
Mutation research 2005;577(1-2):77-91.
2005: W Keither Merritt; Lubomir V Nechev; Tandace A Scholdberg; Stephen M Dean; Sarah E Kiehna; Johanna C Chang; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.
Biochemistry 2005;44(30):10081-92.
2005: W Keither Merritt; Agnieszka Kowalczyk; Tandace A Scholdberg; Stephen M Dean; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adducts: a structural perspective.
Chemical research in toxicology 2005;18(7):1098-107.
2005: Priscilla H Fernandes; Manorama Kanuri; Lubomir V Nechev; Thomas Harris; R Stephen Lloyd
Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde.
Environmental and molecular mutagenesis 2005;45(5):455-9.
2005: Tandace A Scholdberg; W Keither Merritt; Stephen M Dean; Agnieska Kowalcyzk; Constance M Harris; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.
Biochemistry 2005;44(9):3327-37.
2005: Irina G Minko; Andrew J Kurtz; Deborah L Croteau; Bennett Van Houten; Thomas Harris; R Stephen Lloyd
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease.
Biochemistry 2005;44(8):3000-9.
2005: Tandace A Scholdberg; Lubomir V Nechev; W Keither Merritt; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction.
Chemical research in toxicology 2005;18(2):145-53.
2004: Raymond C Manuel; Kenichi Hitomi; Andrew S Arvai; Paul G House; Andrew J Kurtz; ML Dodson; Amanda K McCullough; John A Tainer; R Stephen Lloyd
Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.
The Journal of biological chemistry 2004;279(45):46930-9.
2004: Valeri G Kossykh; R Stephen Lloyd
A DNA adenine methyltransferase of Escherichia coli that is cell cycle regulated and essential for viability.
Journal of bacteriology 2004;186(18):6340.
2004: W Keither Merritt; Tandace A Scholdberg; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Stereospecific structural perturbations arising from adenine N(6) butadiene triol adducts in duplex DNA.
Chemical research in toxicology 2004;17(8):1007-19.
2004: M Todd Washington; Irina G Minko; Robert E Johnson; Lajos Haracska; Thomas Harris; R Stephen Lloyd; Satya Prakash; Louise Prakash
Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.
Molecular and cellular biology 2004;24(16):6900-6.
2004: M Todd Washington; Irina G Minko; Robert E Johnson; William T Wolfle; Thomas Harris; R Stephen Lloyd; Satya Prakash; Louise Prakash
Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.
Molecular and cellular biology 2004;24(13):5687-93.
2004: Tandace A Scholdberg; Lubomir V Nechev; W Keither Merritt; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA adduct of butadiene diol epoxide.
Chemical research in toxicology 2004;17(6):717-30.
2004: Yue Zou; Huaxian Ma; Irina G Minko; Steven M Shell; Zhengguan Yang; Youxing Qu; Ying Xu; Nicholas E Geacintov; R Stephen Lloyd
DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair.
Biochemistry 2004;43(14):4196-205.
2004: Valeri G Kossykh; R Stephen Lloyd
A DNA adenine methyltransferase of Escherichia coli that is cell cycle regulated and essential for viability.
Journal of bacteriology 2004;186(7):2061-7.
2004: Michael G Meador; Lavanya Rajagopalan; R Stephen Lloyd; ML Dodson
Role of His-16 in turnover of T4 pyrimidine dimer glycosylase.
The Journal of biological chemistry 2004;279(5):3348-53.
2003: John Sullivan; Pamela D Diamond; Cheryl L Kaplan; Travis J Mader; RayKay Santa; R Stephen Lloyd
Community outreach as an iterative dialogue among scientists and communities in the Texas gulf coast region.
Mutation research 2003;544(2-3):331-8.
2003: Ana M Sanchez; David Volk; David Gorenstein; R Stephen Lloyd
Initiation of repair of A/G mismatches is modulated by sequence context.
DNA repair 2003;2(8):863-78.
2003: Ana M Sanchez; Irina G Minko; Andrew J Kurtz; Manorama Kanuri; Masaaki Moriya; R Stephen Lloyd
Comparative evaluation of the bioreactivity and mutagenic spectra of acrolein-derived alpha-HOPdG and gamma-HOPdG regioisomeric deoxyguanosine adducts.
Chemical research in toxicology 2003;16(8):1019-28.
2003: Randall Hayden; P A Isotalo; T Parrett; Donna Wolk; X Qian; GD Roberts; R Stephen Lloyd
In situ hybridization for the differentiation of Aspergillus, Fusarium, and Pseudallescheria species in tissue section.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2003;12(1):21-6.
2003: Andrew J Kurtz; R Stephen Lloyd
1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage.
The Journal of biological chemistry 2003;278(8):5970-6.
2003: Graciela Spivak; R Stephen Lloyd; K S Sweder
Workshop on DNA repair and related DNA transactions, a conference report.
DNA repair 2003;2(2):235-42.
2003: Irina G Minko; M Todd Washington; Manorama Kanuri; Louise Prakash; Satya Prakash; R Stephen Lloyd
Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta.
The Journal of biological chemistry 2003;278(2):784-90.
2003: Jeffrey K Wickliffe; Marinel M Ammenheuser; James J Salazar; Sherif Z Abdel-Rahman; Darlene A Hastings-Smith; Edward M Postlethwait; R Stephen Lloyd; Jonathan B Ward
A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.
Environmental and molecular mutagenesis 2003;42(2):106-10.
2003: Priscilla H Fernandes; Hao Wang; Carmelo J Rizzo; R Stephen Lloyd
Site-specific mutagenicity of stereochemically defined 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal in mammalian cells.
Environmental and molecular mutagenesis 2003;42(2):68-74.
2002: Rami Kantor; Lynn S Zijenah; Robert W Shafer; Solomon Mutetwa; Elizabeth Johnston; R Stephen Lloyd; Andrea von Lieven; Dennis Israelski; David A Katzenstein
HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy.
AIDS research and human retroviruses 2002;18(18):1407-13.
2002: Manorama Kanuri; Lubomir V Nechev; Pamela J Tamura; Constance M Harris; Thomas Harris; R Stephen Lloyd
Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells.
Chemical research in toxicology 2002;15(12):1572-80.
2002: John M Fortune; Jennifer S Dickey; Oleg V Lavrukhin; James L Van Etten; R Stephen Lloyd; Neil Osheroff
Site-specific DNA cleavage by Chlorella virus topoisomerase II.
Biochemistry 2002;41(39):11761-9.
2002: Andrew J Kurtz; ML Dodson; R Stephen Lloyd
Evidence for multiple imino intermediates and identification of reactive nucleophiles in peptide-catalyzed beta-elimination at abasic sites.
Biochemistry 2002;41(22):7054-64.
2002: Randall Hayden; X Qian; G W Procop; GD Roberts; R Stephen Lloyd
In situ hybridization for the identification of filamentous fungi in tissue section.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2002;11(2):119-26.
2002: Manorama Kanuri; Irina G Minko; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd
Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells.
The Journal of biological chemistry 2002;277(21):18257-65.
2002: ML Dodson; R Stephen Lloyd
Mechanistic comparisons among base excision repair glycosylases.
Free radical biology & medicine 2002;32(8):678-82.
2002: Agnieszka Kowalczyk; J Russ Carmical; Yue Zou; Bennett Van Houten; R Stephen Lloyd; Constance M Harris; Thomas Harris
Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines.
Biochemistry 2002;41(9):3109-18.
2002: Irina G Minko; Yue Zou; R Stephen Lloyd
Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):1905-9.
2002: Pawel Jaruga; Ritche Jabil; Amanda K McCullough; Henry Rodriguez; Miral Dizdaroglu; R Stephen Lloyd
Chlorella virus pyrimidine dimer glycosylase excises ultraviolet radiation- and hydroxyl radical-induced products 4,6-diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from DNA.
Photochemistry and photobiology 2002;75(2):85-91.
2002: Sarah Burgess; Pawel Jaruga; ML Dodson; Miral Dizdaroglu; R Stephen Lloyd
Determination of active site residues in Escherichia coli endonuclease VIII.
The Journal of biological chemistry 2002;277(4):2938-44.
2002: ML Dodson; Andrew J Kurtz; R Stephen Lloyd
T4 endonuclease V: use of NMR and borohydride trapping to provide evidence for covalent enzyme-substrate imine intermediate.
Methods in enzymology 2002;354():202-7.
2001: ML Dodson; R Stephen Lloyd
Backbone dynamics of DNA containing 8-oxoguanine: importance for substrate recognition by base excision repair glycosylases.
Mutation research 2001;487(3-4):93-108.
2001: C Fu; S Bardhan; N D Cetateanu; Barbara D Wamil; Yihan Wang; He-ping Yan; EG Shi; C Carter; Christo D Venkov; F Michael Yakes; D L Page; R Stephen Lloyd; Raymond L Mernaugh; Carl Hellerqvist
Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4182-94.
2001: Ivan D Kozekov; Lubomir V Nechev; A Sanchez; Constance M Harris; R Stephen Lloyd; Thomas Harris
Interchain cross-linking of DNA mediated by the principal adduct of acrolein.
Chemical research in toxicology 2001;14(11):1482-5.
2001: Miral Dizdaroglu; S M Burgess; Pawel Jaruga; Tapas K Hazra; Henry Rodriguez; R Stephen Lloyd
Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals.
Biochemistry 2001;40(40):12150-6.
2001: Istvan Boldogh; D Milligan; M S Lee; Heather M Bassett; R Stephen Lloyd; Amanda K McCullough
hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs.
Nucleic acids research 2001;29(13):2802-9.
2001: John M Fortune; Oleg V Lavrukhin; James R Gurnon; James L Van Etten; R Stephen Lloyd; Neil Osheroff
Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity.
The Journal of biological chemistry 2001;276(26):24401-8.
2001: Tapas K Hazra; James G Muller; Raymond C Manuel; Cynthia J Burrows; R Stephen Lloyd; Sankar Mitra
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli.
Nucleic acids research 2001;29(9):1967-74.
2001: Irina G Minko; Stanley Hattman; R Stephen Lloyd; Valeri G Kossykh
Methylation by a mutant T2 DNA [N(6)-adenine] methyltransferase expands the usage of RecA-assisted endonuclease (RARE) cleavage.
Nucleic acids research 2001;29(7):1484-90.
2001: Randall Hayden; X Qian; GD Roberts; R Stephen Lloyd
In situ hybridization for the identification of yeastlike organisms in tissue section.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2001;10(1):15-23.
2001: Irina G Minko; M Todd Washington; Louise Prakash; Satya Prakash; R Stephen Lloyd
Translesion DNA synthesis by yeast DNA polymerase eta on templates containing N2-guanine adducts of 1,3-butadiene metabolites.
The Journal of biological chemistry 2001;276(4):2517-22.
2001: Amanda K McCullough; A Sanchez; ML Dodson; P Marapaka; J S Taylor; R Stephen Lloyd
The reaction mechanism of DNA glycosylase/AP lyases at abasic sites.
Biochemistry 2001;40(2):561-8.
2001: Manorama Kanuri; JI Finneman; Constance M Harris; Thomas Harris; R Stephen Lloyd
Efficient nonmutagenic replication bypass of DNAs containing beta-adducts of styrene oxide at adenine N(6).
Environmental and molecular mutagenesis 2001;38(4):357-60.
2001: D A Rodriguez; Agnieszka Kowalczyk; Jonathan B Ward; Constance M Harris; Thomas Harris; R Stephen Lloyd
Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts.
Environmental and molecular mutagenesis 2001;38(4):292-6.
2001: Paul G House; David Volk; Varatharasa Thiviyanathan; Raymond C Manuel; Bruce A Luxon; David Gorenstein; R Stephen Lloyd
Potential double-flipping mechanism by E. coli MutY.
Progress in nucleic acid research and molecular biology 2001;68():349-64.
2001: R Stephen Lloyd
Processivity of DNA repair enzymes.
Methods in molecular biology (Clifton, N.J.) 2001;160():3-14.
2000: Oleg V Lavrukhin; R Stephen Lloyd
Involvement of phylogenetically conserved acidic amino acid residues in catalysis by an oxidative DNA damage enzyme formamidopyrimidine glycosylase.
Biochemistry 2000;39(49):15266-71.
2000: SG Nyaga; R Stephen Lloyd
Two glycosylase/abasic lyases from Neisseria mucosa that initiate DNA repair at sites of UV-induced photoproducts.
The Journal of biological chemistry 2000;275(31):23569-76.
2000: J Russ Carmical; Agnieszka Kowalczyk; Yue Zou; Bennett Van Houten; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis.
The Journal of biological chemistry 2000;275(26):19482-9.
2000: David Volk; Paul G House; Varatharasa Thiviyanathan; Bruce A Luxon; S Zhang; R Stephen Lloyd; David Gorenstein
Structural similarities between MutT and the C-terminal domain of MutY.
Biochemistry 2000;39(25):7331-6.
2000: D A Vasquez; SG Nyaga; R Stephen Lloyd
Purification and characterization of a novel UV lesion-specific DNA glycosylase/AP lyase from Bacillus sphaericus.
Mutation research 2000;459(4):307-16.
2000: G J Latham; E Forgacs; William A Beard; Rajendra Prasad; Katarzyna Bebenek; T A Kunkel; Samuel H Wilson; R Stephen Lloyd
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove.
The Journal of biological chemistry 2000;275(20):15025-33.
2000: Oleg V Lavrukhin; John M Fortune; Thomas G Wood; DE Burbank; James L Van Etten; Neil Osheroff; R Stephen Lloyd
Topoisomerase II from Chlorella virus PBCV-1. Characterization of the smallest known type II topoisomerase.
The Journal of biological chemistry 2000;275(10):6915-21.
2000: Colleen E Piersen; Amanda K McCullough; R Stephen Lloyd
AP lyases and dRPases: commonality of mechanism.
Mutation research 2000;459(1):43-53.
2000: J F Garvish; R Stephen Lloyd
Active-site determination of a pyrimidine dimer glycosylase.
Journal of molecular biology 2000;295(3):479-88.
2000: J Russ Carmical; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Mutagenic potential of adenine N(6) adducts of monoepoxide and diolepoxide derivatives of butadiene.
Environmental and molecular mutagenesis 2000;35(1):48-56.
2000: L Sun; Y Li; Amanda K McCullough; Thomas G Wood; R Stephen Lloyd; Byron Adams; James R Gurnon; James L Van Etten
Intron conservation in a UV-specific DNA repair gene encoded by chlorella viruses.
Journal of molecular evolution 2000;50(1):82-92.
2000: J Russ Carmical; M Zhang; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide.
Chemical research in toxicology 2000;13(1):18-25.
1999: David Volk; Varatharasa Thiviyanathan; Paul G House; R Stephen Lloyd; David Gorenstein
1H, 13C and 15N resonance assignments of the C-terminal domain of MutY: an adenine glycosylase active on G:A mismatches.
Journal of biomolecular NMR 1999;14(4):385-6.
1999: J F Garvish; R Stephen Lloyd
The catalytic mechanism of a pyrimidine dimer-specific glycosylase (pdg)/abasic lyase, Chlorella virus-pdg.
The Journal of biological chemistry 1999;274(14):9786-94.
1999: Amanda K McCullough; ML Dodson; R Stephen Lloyd
Initiation of base excision repair: glycosylase mechanisms and structures.
Annual review of biochemistry 1999;68():255-85.
1999: R Stephen Lloyd
The initiation of DNA base excision repair of dipyrimidine photoproducts.
Progress in nucleic acid research and molecular biology 1999;62():155-75.
1998: Y Guan; Raymond C Manuel; Andrew S Arvai; SS Parikh; Clifford D Mol; J H Miller; R Stephen Lloyd; John A Tainer
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.
Nature structural biology 1998;5(12):1058-64.
1998: IS Zegar; P Chary; R J Jabil; Pamela J Tamura; T N Johansen; R Stephen Lloyd; Constance M Harris; Thomas Harris; Michael P Stone
Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.
Biochemistry 1998;37(47):16516-28.
1998: R Stephen Lloyd
Base excision repair of cyclobutane pyrimidine dimers.
Mutation research 1998;408(3):159-70.
1998: Amanda K McCullough; M T Romberg; SG Nyaga; Y Wei; Thomas G Wood; J S Taylor; James L Van Etten; ML Dodson; R Stephen Lloyd
Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1.
The Journal of biological chemistry 1998;273(21):13136-42.
1998: Oleg V Lavrukhin; R Stephen Lloyd
Mutagenic replication in a human cell extract of DNAs containing site-specific and stereospecific benzo(a)pyrene-7,8-diol-9,10-epoxide DNA adducts placed on the leading and lagging strands.
Cancer research 1998;58(5):887-91.
1997: A G McNees; M O'Donnell; P H Horton; H Y Kim; S J Kim; Constance M Harris; Thomas Harris; R Stephen Lloyd
Lack of correlation between in vitro and in vivo replication of precisely defined benz-a-anthracene adducted DNAs.
The Journal of biological chemistry 1997;272(52):33211-9.
1997: Amanda K McCullough; ML Dodson; O D Schärer; R Stephen Lloyd
The role of base flipping in damage recognition and catalysis by T4 endonuclease V.
The Journal of biological chemistry 1997;272(43):27210-7.
1997: Raymond C Manuel; R Stephen Lloyd
Cloning, overexpression, and biochemical characterization of the catalytic domain of MutY.
Biochemistry 1997;36(37):11140-52.
1997: M J McCarthy; J I Rosenblatt; R Stephen Lloyd
Kinetics of repair of UV-induced DNA damage in repair-proficient and -deficient cells as determined by quantitative polymerase chain reaction.
Photochemistry and photobiology 1997;66(3):356-62.
1997: SG Nyaga; ML Dodson; R Stephen Lloyd
Role of specific amino acid residues in T4 endonuclease V that alter nontarget DNA binding.
Biochemistry 1997;36(14):4080-8.
1997: M Furuta; JO Schrader; HS Schrader; Tyler A Kokjohn; SG Nyaga; Amanda K McCullough; R Stephen Lloyd; DE Burbank; D Landstein; L Lane; James L Van Etten
Chlorella virus PBCV-1 encodes a homolog of the bacteriophage T4 UV damage repair gene denV.
Applied and environmental microbiology 1997;63(4):1551-6.
1997: E Forgacs; G Latham; William A Beard; Rajendra Prasad; Katarzyna Bebenek; T A Kunkel; Samuel H Wilson; R Stephen Lloyd
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts.
The Journal of biological chemistry 1997;272(13):8525-30.
1997: P Chary; Constance M Harris; Thomas Harris; R Stephen Lloyd
Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates.
The Journal of biological chemistry 1997;272(9):5805-13.
1997: R Stephen Lloyd; Xiaodong Cheng
Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping.
Biopolymers 1997;44(2):139-51.
1996: Amanda K McCullough; Orlando D Schärer; G L Verdine; R Stephen Lloyd
Structural determinants for specific recognition by T4 endonuclease V.
The Journal of biological chemistry 1996;271(50):32147-52.
1996: Carl Hellerqvist; R Stephen Lloyd; E Wang; S Bardhan
Modulation of interleukin-12 mRNA expression in leukocytes of cancer patients treated with CM101.
Annals of the New York Academy of Sciences 1996;795():346-8.
1996: G J Latham; A G McNees; B De Corte; Constance M Harris; Thomas Harris; M O'Donnell; R Stephen Lloyd
Comparison of the efficiency of synthesis past single bulky DNA adducts in vivo and in vitro by the polymerase III holoenzyme.
Chemical research in toxicology 1996;9(7):1167-75.
1996: Colleen E Piersen; Rajendra Prasad; Samuel H Wilson; R Stephen Lloyd
Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction.
The Journal of biological chemistry 1996;271(30):17811-5.
1996: R C Manuel; E W Czerwinski; R Stephen Lloyd
Identification of the structural and functional domains of MutY, an Escherichia coli DNA mismatch repair enzyme.
The Journal of biological chemistry 1996;271(27):16218-26.
1996: M J McCarthy; J I Rosenblatt; R Stephen Lloyd
A modified quantitative polymerase chain reaction assay for measuring gene-specific repair of UV photoproducts in human cells.
Mutation research 1996;363(1):57-66.
1996: Malgorzata M Slupska; C Baikalov; R Stephen Lloyd; Jeffrey H Miller
Mutator tRNAs are encoded by the Escherichia coli mutator genes mutA and mutC: a novel pathway for mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4380-5.
1996: P Chary; R Stephen Lloyd
Impact of the stereochemistry of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide-deoxyadenosine adducts on resistance to digestion by phosphodiesterases I and II and translesion synthesis with HIV-1 reverse transcriptase.
Chemical research in toxicology 1996;9(2):409-17.
1996: K A Latham; S Rajendran; J R Carmical; J Ching Lee; R Stephen Lloyd
T4 endonuclease V exists in solution as a monomer and binds to target sites as a monomer.
Biochimica et biophysica acta 1996;1292(2):324-34.
1996: Miral Dizdaroglu; TH Zastawny; J R Carmical; R Stephen Lloyd
A novel DNA N-glycosylase activity of E. coli T4 endonuclease V that excises 4,6-diamino-5-formamidopyrimidine from DNA, a UV-radiation- and hydroxyl radical-induced product of adenine.
Mutation research 1996;362(1):1-8.
1995: Colleen E Piersen; Melissa A Prince; M L Augustine; ML Dodson; R Stephen Lloyd
Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/abasic lyase that proceeds via an imino enzyme-DNA intermediate.
The Journal of biological chemistry 1995;270(40):23475-84.
1995: K A Latham; R C Manuel; R Stephen Lloyd
The interaction of T4 endonuclease V E23Q mutant with thymine dimer- and tetrahydrofuran-containing DNA.
Journal of bacteriology 1995;177(17):5166-8.
1995: B Sun; K A Latham; ML Dodson; R Stephen Lloyd
Studies on the catalytic mechanism of five DNA glycosylases. Probing for enzyme-DNA imino intermediates.
The Journal of biological chemistry 1995;270(33):19501-8.
1995: K A Latham; R Stephen Lloyd
Delta-elimination by T4 endonuclease V at a thymine dimer site requires a secondary binding event and amino acid Glu-23.
Biochemistry 1995;34(27):8796-803.
1995: P Chary; R Stephen Lloyd
In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts.
Nucleic acids research 1995;23(8):1398-405.
1995: G J Latham; Constance M Harris; Thomas Harris; R Stephen Lloyd
The efficiency of translesion synthesis past single styrene oxide DNA adducts in vitro is polymerase-specific.
Chemical research in toxicology 1995;8(3):422-30.
1995: P Chary; G J Latham; D L Robberson; S J Kim; S Han; Constance M Harris; Thomas Harris; R Stephen Lloyd
In vivo and in vitro replication consequences of stereoisomeric benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the second position of N-ras codon 61.
The Journal of biological chemistry 1995;270(10):4990-5000.
1995: K A Latham; J S Taylor; R Stephen Lloyd
T4 endonuclease V protects the DNA strand opposite a thymine dimer from cleavage by the footprinting reagents DNase I and 1,10-phenanthroline-copper.
The Journal of biological chemistry 1995;270(8):3765-71.
1995: R C Manuel; K A Latham; ML Dodson; R Stephen Lloyd
Involvement of glutamic acid 23 in the catalytic mechanism of T4 endonuclease V.
The Journal of biological chemistry 1995;270(6):2652-61.
1994: ML Dodson; M L Michaels; R Stephen Lloyd
Unified catalytic mechanism for DNA glycosylases.
The Journal of biological chemistry 1994;269(52):32709-12.
1994: G J Latham; R Stephen Lloyd
Deoxynucleotide polymerization by HIV-1 reverse transcriptase is terminated by site-specific styrene oxide adducts after translesion synthesis.
The Journal of biological chemistry 1994;269(46):28527-30.
1994: K A Latham; J R Carmical; R Stephen Lloyd
Mutation of tryptophan 128 in T4 endonuclease V does not affect glycosylase or abasic site lyase activity.
Biochemistry 1994;33(30):9024-31.
1994: C J Jones; R Stephen Lloyd; R D Wood
Analysis of cells harboring a putative DNA repair gene reveals a lack of evidence for a second independent xeroderma pigmentosum group A correcting gene.
Mutation research 1994;324(4):159-64.
1994: K A Latham; R Stephen Lloyd
T4 endonuclease V. Perspectives on catalysis.
Annals of the New York Academy of Sciences 1994;726():181-96; discussion 196-7.
1993: G J Latham; L Zhou; Constance M Harris; Thomas Harris; R Stephen Lloyd
The replication fate of R- and S-styrene oxide adducts on adenine N6 is dependent on both the chirality of the lesion and the local sequence context.
The Journal of biological chemistry 1993;268(31):23427-34.
1993: Kristina E Hill; R Stephen Lloyd; Raymond F Burk
Conserved features of selenoprotein P cDNA.
Biochemical Society transactions 1993;21(4):832-5.
1993: ML Dodson; R D Schrock; R Stephen Lloyd
Evidence for an imino intermediate in the T4 endonuclease V reaction.
Biochemistry 1993;32(32):8284-90.
1993: M Higley; R Stephen Lloyd
Processivity of uracil DNA glycosylase.
Mutation research 1993;294(2):109-16.
1993: Kristina E Hill; R Stephen Lloyd; Raymond F Burk
Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):537-41.
1993: R D Schrock; R Stephen Lloyd
Site-directed mutagenesis of the NH2 terminus of T4 endonuclease V. The position of the alpha NH2 moiety affects catalytic activity.
The Journal of biological chemistry 1993;268(2):880-6.
1993: T Mori; T L Rinaldy; Raghbir S Athwal; Pali Kaur; O Nikaido; R Stephen Lloyd; A Rinaldy
A xeroderma pigmentosum complementation group A related gene: confirmation using monoclonal antibodies against the cyclobutane dimer and (6-4) photoproduct.
Mutation research 1993;293(2):143-50.
1992: Pali Kaur; A Rinaldy; R Stephen Lloyd; Raghbir S Athwal
A gene that partially complements xeroderma pigmentosum group A cells maps to human chromosome 8.
Somatic cell and molecular genetics 1992;18(4):371-9.
1992: Jon M Hanifin; R Stephen Lloyd; K Okubo; L L Guerin; L Fancher; S C Chan
Relationship between increased cyclic AMP-phosphodiesterase activity and abnormal adenylyl cyclase regulation in leukocytes from patients with atopic dermatitis.
The Journal of investigative dermatology 1992;98(6 Suppl):100S-105S.
1992: C Nickell; Melissa A Prince; R Stephen Lloyd
Consequences of molecular engineering enhanced DNA binding in a DNA repair enzyme.
Biochemistry 1992;31(17):4189-98.
1992: J L Cmarik; W G Humphreys; K L Bruner; R Stephen Lloyd; C Tibbetts; F Peter Guengerich
Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide.
The Journal of biological chemistry 1992;267(10):6672-9.
1991: Anita H Corbett; E L Zechiedrich; R Stephen Lloyd; Neil Osheroff
Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers.
The Journal of biological chemistry 1991;266(29):19666-71.
1991: R D Schrock; R Stephen Lloyd
Reductive methylation of the amino terminus of endonuclease V eradicates catalytic activities. Evidence for an essential role of the amino terminus in the chemical mechanisms of catalysis.
The Journal of biological chemistry 1991;266(26):17631-9.
1991: C Nickell; R Stephen Lloyd
Mutations in endonuclease V that affect both protein-protein association and target site location.
Biochemistry 1991;30(35):8638-48.
1991: M L Augustine; R W Hamilton; ML Dodson; R Stephen Lloyd
Oligonucleotide site directed mutagenesis of all histidine residues within the T4 endonuclease V gene: role in enzyme-nontarget DNA binding.
Biochemistry 1991;30(32):8052-9.
1991: ML Dodson; Melissa A Prince; W F Anderson; R Stephen Lloyd
Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions.
Mutation research 1991;255(1):19-29.
1991: Melissa A Prince; B Friedman; Elliott Gruskin; R D Schrock; R Stephen Lloyd
Selective metal binding to Cys-78 within endonuclease V causes an inhibition of catalytic activities without altering nontarget and target DNA binding.
The Journal of biological chemistry 1991;266(16):10686-93.
1991: Kristina E Hill; R Stephen Lloyd; J G Yang; R Read; Raymond F Burk
The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame.
The Journal of biological chemistry 1991;266(16):10050-3.
1991: C Nickell; W F Anderson; R Stephen Lloyd
Substitution of basic amino acids within endonuclease V enhances nontarget DNA binding.
The Journal of biological chemistry 1991;266(9):5634-42.
1991: robert cook; R Stephen Lloyd; Conrad Wagner
Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase.
The Journal of biological chemistry 1991;266(8):4965-73.
1991: D G Stump; R Stephen Lloyd; F Chytil
Site-directed mutagenesis of rat cellular retinol-binding protein. Alteration in binding specificity resulting from mutation of glutamine 108 to arginine.
The Journal of biological chemistry 1991;266(7):4622-30.
1990: A Rinaldy; T Bellew; E Egli; R Stephen Lloyd
Increased UV resistance in xeroderma pigmentosum group A cells after transformation with a human genomic DNA clone.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6818-22.
1990: D R Dowd; R Stephen Lloyd
Biological significance of facilitated diffusion in protein-DNA interactions. Applications to T4 endonuclease V-initiated DNA repair.
The Journal of biological chemistry 1990;265(6):3424-31.
1989: D R Dowd; R Stephen Lloyd
Site-directed mutagenesis of the T4 endonuclease V gene: the role of arginine-3 in the target search.
Biochemistry 1989;28(22):8699-705.
1989: R W Hamilton; R Stephen Lloyd
Modulation of the DNA scanning activity of the Micrococcus luteus UV endonuclease.
The Journal of biological chemistry 1989;264(29):17422-7.
1989: ML Dodson; R Stephen Lloyd
Structure-function studies of the T4 endonuclease V repair enzyme.
Mutation research 1989;218(2):49-65.
1989: D R Dowd; R Stephen Lloyd
Biological consequences of a reduction in the non-target DNA scanning capacity of a DNA repair enzyme.
Journal of molecular biology 1989;208(4):701-7.
1989: W R Brian; P K Srivastava; D R Umbenhauer; R Stephen Lloyd; F Peter Guengerich
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
Biochemistry 1989;28(12):4993-9.
1989: R W Bork; T Muto; Philippe Beaune; P K Srivastava; R Stephen Lloyd; F Peter Guengerich
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
The Journal of biological chemistry 1989;264(2):910-9.
1989: R Stephen Lloyd; M L Augustine
Site-directed mutagenesis of the T4 endonuclease V gene: mutations which enhance enzyme specific activity at low salt concentrations.
Proteins 1989;6(2):128-38.
1989: W R Brian; C Ged; T M Bellew; P K Srivastava; R W Bork; D R Umbenhauer; R Stephen Lloyd; F Peter Guengerich
Human liver mephenytoin 4'-hydroxylase cytochrome P-450 proteins and genes.
Drug metabolism reviews 1989;20(2-4):449-65.
1988: A Rinaldy; ML Dodson; T L Darling; R Stephen Lloyd
Gene cloning using cDNA libraries in a differential competition hybridization strategy: application to cloning XP-A related genes.
DNA (Mary Ann Liebert, Inc.) 1988;7(8):563-70.
1988: C Ged; D R Umbenhauer; T M Bellew; R W Bork; P K Srivastava; N Shinriki; R Stephen Lloyd; F Peter Guengerich
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
Biochemistry 1988;27(18):6929-40.
1988: Elliott Gruskin; R Stephen Lloyd
Molecular analysis of plasmid DNA repair within ultraviolet-irradiated Escherichia coli. II. UvrABC-initiated excision repair and photolyase-catalyzed dimer monomerization.
The Journal of biological chemistry 1988;263(25):12738-43.
1988: Elliott Gruskin; R Stephen Lloyd
Molecular analysis of plasmid DNA repair within ultraviolet-irradiated Escherichia coli. I. T4 endonuclease V-initiated excision repair.
The Journal of biological chemistry 1988;263(25):12728-37.
1988: D G Stump; R Stephen Lloyd
Site-directed mutagenesis of the T4 endonuclease V gene: role of tyrosine-129 and -131 in pyrimidine dimer-specific binding.
Biochemistry 1988;27(6):1839-43.
1988: A Recinos; R Stephen Lloyd
Site-directed mutagenesis of the T4 endonuclease V gene: role of lysine-130.
Biochemistry 1988;27(6):1832-8.
1988: S G Lee; G A Ricca; G Crumley; R Stephen Lloyd; W Drohan
Modulation of expression of the human gamma interferon gene in E. coli by site-directed mutagenesis.
Biochemical and biophysical research communications 1988;151(1):598-607.
1987: F Peter Guengerich; Philippe Beaune; D R Umbenhauer; P F Churchill; R W Bork; G A Dannan; Robert G Knodell; R Stephen Lloyd; M V Martin
Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans.
Biochemical Society transactions 1987;15(4):576-8.
1987: R Stephen Lloyd; M L Augustine
High-frequency spontaneous deletion of DNA sequences flanked by direct DNA repeats which also contain an internal palindrome.
Mutation research 1987;179(2):135-42.
1987: D R Sherman; R Stephen Lloyd; F Chytil
Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3209-13.
1987: F Peter Guengerich; D R Umbenhauer; P F Churchill; Philippe Beaune; R Böcker; Robert G Knodell; M V Martin; R Stephen Lloyd
Polymorphism of human cytochrome P-450.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(3):311-6.
1987: K M Higgins; R Stephen Lloyd
Purification of the T4 endonuclease V.
Mutation research 1987;183(2):117-21.
1987: R Stephen Lloyd; M L Dodson; Elliott Gruskin; D L Robberson
T4 endonuclease V promotes the formation of multimeric DNA structures.
Mutation research 1987;183(2):109-15.
1987: D R Umbenhauer; M V Martin; R Stephen Lloyd; F P Guengerich
Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase.
Biochemistry 1987;26(4):1094-9.
1986: A Recinos; M L Augustine; K M Higgins; R Stephen Lloyd
Expression of the bacteriophage T4 denV structural gene in Escherichia coli.
Journal of bacteriology 1986;168(2):1014-8.
1986: Philippe Beaune; D R Umbenhauer; R W Bork; R Stephen Lloyd; F Peter Guengerich
Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8064-8.
1986: A Recinos; R Stephen Lloyd
Efficient screening of recombinant DNA junctions afforded by probing with synthetic "bridge" oligonucleotides.
Biochemical and biophysical research communications 1986;138(2):945-52.
1986: Elliott Gruskin; R Stephen Lloyd
The DNA scanning mechanism of T4 endonuclease V. Effect of NaCl concentration on processive nicking activity.
The Journal of biological chemistry 1986;261(21):9607-13.
1986: R Stephen Lloyd; M L Augustine
Cloning and expression of the 3' portion of the T4 denV gene as a lacZ fusion gene.
Mutation research 1986;165(2):89-100.
1982: P C Hanawalt; P K Cooper; A K Ganesan; R Stephen Lloyd; C A Smith; M E Zolan
Repair responses to DNA damage: enzymatic pathways in E coli and human cells.
Journal of cellular biochemistry 1982;18(3):271-83.
1981: R Stephen Lloyd; P C Hanawalt
Expression of the denV gene of bacteriophage T4 cloned in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(5):2796-800.
1980: R Stephen Lloyd; P C Hanawalt; M L Dodson
Processive action of T4 endonuclease V on ultraviolet-irradiated DNA.
Nucleic acids research 1980;8(21):5113-27.
1979: R Stephen Lloyd; C W Haidle; D L Robberson
Bleomycin fragmentation of duplex DNA occurs as staggered single-strand scissions.
Gene 1979;7(3-4):303-16.
1979: R Stephen Lloyd; C W Haidle; D L Robberson
Site specificity of bleomycin-mediated single-strand scissions and alkali-labile damage in duplex DNA.
Gene 1979;7(3-4):289-302.