Roy Lobb

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Hahm Kyungmin; Lukashev Matvey E; Luo Yi; Yang William J; Dolinski Brian M; Weinreb Paul H; Simon Kenneth J; Chun Wang Li; Leone Diane R; Lobb Roy R; McCrann Donald J; Allaire Normand E; Horan Gerald S; Fogo Agnes; Kalluri Raghu; Shield Charles F; Sheppard Dean; Gardner Humphrey A; Violette Shelia M
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.
Pepinsky R B; Lee W-C; Cornebise M; Gill A; Wortham K; Chen L L; Leone D R; Giza K; Dolinski B M; Perper S; Nickerson-Nutter C; Lepage D; Chakraborty A; Whalley E T; Petter R C; Adams S P; Lobb R R; Scott D M
Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties.
Olson Dian L; Burkly Linda C; Leone Diane R; Dolinski Brian M; Lobb Roy R
Anti-alpha4 integrin monoclonal antibody inhibits multiple myeloma growth in a murine model.

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2007: Hahm Kyungmin; Lukashev Matvey E; Luo Yi; Yang William J; Dolinski Brian M; Weinreb Paul H; Simon Kenneth J; Chun Wang Li; Leone Diane R; Lobb Roy R; McCrann Donald J; Allaire Normand E; Horan Gerald S; Fogo Agnes; Kalluri Raghu; Shield Charles F; Sheppard Dean; Gardner Humphrey A; Violette Shelia M
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.
The American journal of pathology 2007;170(1):110-25.
2005: Pepinsky R B; Lee W-C; Cornebise M; Gill A; Wortham K; Chen L L; Leone D R; Giza K; Dolinski B M; Perper S; Nickerson-Nutter C; Lepage D; Chakraborty A; Whalley E T; Petter R C; Adams S P; Lobb R R; Scott D M
Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties.
The Journal of pharmacology and experimental therapeutics 2005;312(2):742-50.
2005: Olson Dian L; Burkly Linda C; Leone Diane R; Dolinski Brian M; Lobb Roy R
Anti-alpha4 integrin monoclonal antibody inhibits multiple myeloma growth in a murine model.
Molecular cancer therapeutics 2005;4(1):91-9.
2004: Abraham William M; Ahmed Ashfaq; Serebriakov Irakli; Carmillo Amie N; Ferrant Janine; de Fougerolles Antonin R; Garber Ellen A; Gotwals Philip J; Koteliansky Victor E; Taylor Fred; Lobb Roy R
A monoclonal antibody to alpha1beta1 blocks antigen-induced airway responses in sheep.
American journal of respiratory and critical care medicine 2004;169(1):97-104.
2004: Singh Juswinder; Adams Steve; Carter Mary Beth; Cuervo Hernan; Lee Wen-Cherng; Lobb Roy R; Pepinsky R Blake; Petter Russell; Scott Daniel
Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma.
Current topics in medicinal chemistry 2004;4(14):1497-507.
2003: Leone D R; Giza K; Gill A; Dolinski B M; Yang W; Perper S; Scott D M; Lee W-C; Cornebise M; Wortham K; Nickerson-Nutter C; Chen L L; LePage D; Spell J C; Whalley E T; Petter R C; Adams S P; Lobb R R; Pepinsky R B
An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1150-62.
2003: Marcinkiewicz Cezary; Weinreb Paul H; Calvete Juan J; Kisiel Dariusz G; Mousa Shaker A; Tuszynski George P; Lobb Roy R
Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo.
Cancer research 2003;63(9):2020-3.
2002: Weinreb Paul H; Yang William J; Violette Shelia M; Couture Megan; Kimball Kathleen; Pepinsky R Blake; Lobb Roy R; Josiah Serene
A cell-free electrochemiluminescence assay for measuring beta1-integrin-ligand interactions.
Analytical biochemistry 2002;306(2):305-13.
2002: Pepinsky R Blake; Mumford Richard A; Chen Ling Ling; Leone Diane; Amo Suzanne E; Riper Gail Van; Whitty Adrian; Dolinski Brian; Lobb Roy R; Dean Dennis C; Chang Linda L; Raab Conrad E; Si Qian; Hagmann William K; Lingham Russell B
Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.
Biochemistry 2002;41(22):7125-41.
2002: Leussink V I; Zettl U K; Jander S; Pepinsky R B; Lobb R R; Stoll G; Toyka K V; Gold R
Blockade of signaling via the very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) causes increased T cell apoptosis in experimental autoimmune neuritis.
Acta neuropathologica 2002;103(2):131-6.
2002: Lobb Roy R
Cell-matrix adhesion research and the development of biotherapeutics.
Methods in cell biology 2002;69():17-23.
2001: Chen L L; Whitty A; Scott D; Lee W C; Cornebise M; Adams S P; Petter R C; Lobb R R; Pepinsky R B
Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.
The Journal of biological chemistry 2001;276(39):36520-9.
2001: Feigelson S W; Grabovsky V; Winter E; Chen L L; Pepinsky R B; Yednock T; Yablonski D; Lobb R; Alon R
The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.
The Journal of biological chemistry 2001;276(17):13891-901.
2001: Relton J K; Sloan K E; Frew E M; Whalley E T; Adams S P; Lobb R R
Inhibition of alpha4 integrin protects against transient focal cerebral ischemia in normotensive and hypertensive rats.
Stroke; a journal of cerebral circulation 2001;32(1):199-205.
2000: Wang Q; Wang Y; Hyde D M; Gotwals P J; Lobb R R; Ryan S T; Giri S N
Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice.
Biochemical pharmacology 2000;60(12):1949-58.
2000: Marcinkiewicz C; Taooka Y; Yokosaki Y; Calvete J J; Marcinkiewicz M M; Lobb R R; Niewiarowski S; Sheppard D
Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.
The Journal of biological chemistry 2000;275(41):31930-7.
2000: Grabovsky V; Feigelson S; Chen C; Bleijs D A; Peled A; Cinamon G; Baleux F; Arenzana-Seisdedos F; Lapidot T; van Kooyk Y; Lobb R R; Alon R
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions.
The Journal of experimental medicine 2000;192(4):495-506.
2000: Abraham W M; Gill A; Ahmed A; Sielczak M W; Lauredo I T; Botinnikova Y; Lin K C; Pepinsky B; Leone D R; Lobb R R; Adams S P
A small-molecule, tight-binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):603-11.
2000: Marcinkiewicz C; Lobb R R; Marcinkiewicz M M; Daniel J L; Smith J B; Dangelmaier C; Weinreb P H; Beacham D A; Niewiarowski S
Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin.
Biochemistry 2000;39(32):9859-67.
2000: de Fougerolles A R; Sprague A G; Nickerson-Nutter C L; Chi-Rosso G; Rennert P D; Gardner H; Gotwals P J; Lobb R R; Koteliansky V E
Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis.
The Journal of clinical investigation 2000;105(6):721-9.
2000: Labinaz M; Hoffert C; Pels K; Aggarwal S; Pepinsky R B; Leone D; Koteliansky V; Lobb R R; O'Brien E R
Infusion of an antialpha4 integrin antibody is associated with less neoadventitial formation after balloon injury of porcine coronary arteries.
The Canadian journal of cardiology 2000;16(2):187-96.
1999: Marcinkiewicz C; Calvete J J; Vijay-Kumar S; Marcinkiewicz M M; Raida M; Schick P; Lobb R R; Niewiarowski S
Structural and functional characterization of EMF10, a heterodimeric disintegrin from Eristocophis macmahoni venom that selectively inhibits alpha 5 beta 1 integrin.
Biochemistry 1999;38(40):13302-9.
1999: Lobb R R; Adams S P
Small molecule antagonists of alpha4 integrins: novel drugs for asthma.
Expert opinion on investigational drugs 1999;8(7):935-45.
1999: Chen L L; Whitty A; Lobb R R; Adams S P; Pepinsky R B
Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand.
The Journal of biological chemistry 1999;274(19):13167-75.
1999: Marcinkiewicz C; Calvete J J; Marcinkiewicz M M; Raida M; Vijay-Kumar S; Huang Z; Lobb R R; Niewiarowski S
EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits alpha4 and alpha5 integrins in an RGD-independent manner.
The Journal of biological chemistry 1999;274(18):12468-73.
1999: Lin K c; Ateeq H S; Hsiung S H; Chong L T; Zimmerman C N; Castro A; Lee W C; Hammond C E; Kalkunte S; Chen L L; Pepinsky R B; Leone D R; Sprague A G; Abraham W M; Gill A; Lobb R R; Adams S P
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.
Journal of medicinal chemistry 1999;42(5):920-34.
1999: Chen C; Mobley J L; Dwir O; Shimron F; Grabovsky V; Lobb R R; Shimizu Y; Alon R
High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1084-95.
1998: Enders U; Lobb R; Pepinsky R B; Hartung H P; Toyka K V; Gold R
The role of the very late antigen-4 and its counterligand vascular cell adhesion molecule-1 in the pathogenesis of experimental autoimmune neuritis of the Lewis rat.
Brain : a journal of neurology 1998;121 ( Pt 7)():1257-66.
1998: Chen L L; Lobb R R; Cuervo J H; Lin K c; Adams S P; Pepinsky R B
Identification of ligand binding sites on integrin alpha4beta1 through chemical cross-linking.
Biochemistry 1998;37(24):8743-53.
1997: Pujades C; Alon R; Yauch R L; Masumoto A; Burkly L C; Chen C; Springer T A; Lobb R R; Hemler M E
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.
Molecular biology of the cell 1997;8(12):2647-57.
1996: Lobb R R; Abraham W M; Burkly L C; Gill A; Ma W; Knight J A; Leone D R; Antognetti G; Pepinsky R B
Pathophysiologic role of alpha 4 integrins in the lung.
Annals of the New York Academy of Sciences 1996;796():113-23.
1996: Lobb R R; Pepinsky B; Leone D R; Abraham W M
The role of alpha 4 integrins in lung pathophysiology.
The European respiratory journal. Supplement 1996;22():104s-108s.
1995: Lobb R R; Antognetti G; Pepinsky R B; Burkly L C; Leone D R; Whitty A
A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha 4 integrins.
Cell adhesion and communication 1995;3(5):385-97.
1995: Schiffer S G; Hemler M E; Lobb R R; Tizard R; Osborn L
Molecular mapping of functional antibody binding sites of alpha 4 integrin.
The Journal of biological chemistry 1995;270(24):14270-3.
1995: Jakubowski A; Rosa M D; Bixler S; Lobb R; Burkly L C
Vascular cell adhesion molecule (VCAM)-Ig fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor.
Cell adhesion and communication 1995;3(2):131-42.
1995: Hemler M E; Lobb R R
The leukocyte beta 1 integrins.
Current opinion in hematology 1995;2(1):61-7.
1995: Patel T P; Edge C J; Parekh R B; Goelz S E; Lobb R R
Identification of endogenous protein-associated carbohydrate ligands for E-selectin.
Ciba Foundation symposium 1995;189():212-22; discussion 222-6.
1994: Patel T P; Goelz S E; Lobb R R; Parekh R B
Isolation and characterization of natural protein-associated carbohydrate ligands for E-selectin.
Biochemistry 1994;33(49):14815-24.
1994: Lobb R R; Hemler M E
The pathophysiologic role of alpha 4 integrins in vivo.
The Journal of clinical investigation 1994;94(5):1722-8.
1994: Abraham W M; Sielczak M W; Ahmed A; Cortes A; Lauredo I T; Kim J; Pepinsky B; Benjamin C D; Leone D R; Lobb R R
Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.
The Journal of clinical investigation 1994;93(2):776-87.
1993: Alpers C E; Hudkins K L; Davis C L; Marsh C L; Riches W; McCarty J M; Benjamin C D; Carlos T M; Harlan J M; Lobb R
Expression of vascular cell adhesion molecule-1 in kidney allograft rejection.
Kidney international 1993;44(4):805-16.
1993: Meier W; Leone D R; Miatkowski K; Lobb R; Goelz S E
The ELAM ligand fucosyltransferase, ELFT, directs E-selectin binding to a secreted scaffold protein: a method to produce and purify large quantities of specific carbohydrate structures.
The Biochemical journal 1993;294 ( Pt 1)():25-30.
1993: Podolsky D K; Lobb R; King N; Benjamin C D; Pepinsky B; Sehgal P; deBeaumont M
Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody.
The Journal of clinical investigation 1993;92(1):372-80.
1993: Moy P; Lobb R; Tizard R; Olson D; Hession C
Cloning of an inflammation-specific phosphatidyl inositol-linked form of murine vascular cell adhesion molecule-1.
The Journal of biological chemistry 1993;268(12):8835-41.
1993: Bacchi C E; Marsh C L; Perkins J D; Carithers R L; McVicar J P; Hudkins K L; Benjamin C D; Harlan J M; Lobb R; Alpers C E
Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection.
The American journal of pathology 1993;142(2):579-91.
1992: Koizumi M; King N; Lobb R; Benjamin C; Podolsky D K
Expression of vascular adhesion molecules in inflammatory bowel disease.
Gastroenterology 1992;103(3):840-7.
1992: Postigo A A; Garcia-Vicuña R; Diaz-Gonzalez F; Arroyo A G; De Landázuri M O; Chi-Rosso G; Lobb R R; Laffon A; Sánchez-Madrid F
Increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1).
The Journal of clinical investigation 1992;89(5):1445-52.
1992: Furie M B; Burns M J; Tancinco M C; Benjamin C D; Lobb R R
E-selectin (endothelial-leukocyte adhesion molecule-1) is not required for the migration of neutrophils across IL-1-stimulated endothelium in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2395-404.
1992: Hession C; Moy P; Tizard R; Chisholm P; Williams C; Wysk M; Burkly L; Miyake K; Kincade P; Lobb R
Cloning of murine and rat vascular cell adhesion molecule-1.
Biochemical and biophysical research communications 1992;183(1):163-9.
1991: Burkly L C; Jakubowski A; Newman B M; Rosa M D; Chi-Rosso G; Lobb R R
Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation.
European journal of immunology 1991;21(11):2871-5.
1991: Lobb R; Chi-Rosso G; Leone D; Rosa M; Newman B; Luhowskyj S; Osborn L; Schiffer S; Benjamin C; Dougas I
Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1.
Biochemical and biophysical research communications 1991;178(3):1498-504.
1991: Weller P F; Rand T H; Goelz S E; Chi-Rosso G; Lobb R R
Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7430-3.
1991: Montgomery K F; Osborn L; Hession C; Tizard R; Goff D; Vassallo C; Tarr P I; Bomsztyk K; Lobb R; Harlan J M
Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6523-7.
1991: Lobb R R; Chi-Rosso G; Leone D R; Rosa M D; Bixler S; Newman B M; Luhowskyj S; Benjamin C D; Dougas I G; Goelz S E
Expression and functional characterization of a soluble form of endothelial-leukocyte adhesion molecule 1.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):124-9.
1991: Pulido R; Elices M J; Campanero M R; Osborn L; Schiffer S; García-Pardo A; Lobb R; Hemler M E; Sánchez-Madrid F
Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes.
The Journal of biological chemistry 1991;266(16):10241-5.
1991: Lo S K; Lee S; Ramos R A; Lobb R; Rosa M; Chi-Rosso G; Wright S D
Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.
The Journal of experimental medicine 1991;173(6):1493-500.
1991: Carlos T; Kovach N; Schwartz B; Rosa M; Newman B; Wayner E; Benjamin C; Osborn L; Lobb R; Harlan J
Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1.
Blood 1991;77(10):2266-71.
1991: Hession C; Tizard R; Vassallo C; Schiffer S B; Goff D; Moy P; Chi-Rosso G; Luhowskyj S; Lobb R; Osborn L
Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1).
The Journal of biological chemistry 1991;266(11):6682-5.
1990: Goelz S E; Hession C; Goff D; Griffiths B; Tizard R; Newman B; Chi-Rosso G; Lobb R
ELFT: a gene that directs the expression of an ELAM-1 ligand.
Cell 1990;63(6):1349-56.
1990: Carlos T M; Schwartz B R; Kovach N L; Yee E; Rosa M; Osborn L; Chi-Rosso G; Newman B; Lobb R;
Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells.
Blood 1990;76(5):965-70.
1990: Elices M J; Osborn L; Takada Y; Crouse C; Luhowskyj S; Hemler M E; Lobb R R
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.
Cell 1990;60(4):577-84.
1989: Osborn L; Hession C; Tizard R; Vassallo C; Luhowskyj S; Chi-Rosso G; Lobb R
Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.
Cell 1989;59(6):1203-11.

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Roy Lobb

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