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Stephen Locarnini

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Gail V Matthews; Peter A Revill; Kiat Ruxrungtham; Joseph Sasadeusz; Melissa Saulynas; Eric C Seaberg; Anchalee Avihingsanon; Scott Bowden; Gregory J Dore; Robert Finlayson; Jennifer F Hoy; Sharon R Lewin; Margaret Littlejohn; Stephen Locarnini; Chloe L Thio
Patterns and causes of suboptimal response to tenofovir-based therapy in individuals coinfected with HIV and hepatitis B virus.
Stephen Locarnini; Scott Bowden
Hepatitis B surface antigen quantification: not what it seems on the surface.
Wan-Shoo Cheong; Michiko Hyakumura; Stephen Locarnini; Nadia Warner; Lilly Yuen; Hans J Netter
Modulation of the immunogenicity of virus-like particles composed of mutant hepatitis B virus envelope subunits.

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All Publications

2013: Gail V Matthews; Peter A Revill; Kiat Ruxrungtham; Joseph Sasadeusz; Melissa Saulynas; Eric C Seaberg; Anchalee Avihingsanon; Scott Bowden; Gregory J Dore; Robert Finlayson; Jennifer F Hoy; Sharon R Lewin; Margaret Littlejohn; Stephen Locarnini; Chloe L Thio
Patterns and causes of suboptimal response to tenofovir-based therapy in individuals coinfected with HIV and hepatitis B virus.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013;56(9):e87-94.
2012: Stephen Locarnini; Scott Bowden
Hepatitis B surface antigen quantification: not what it seems on the surface.
Hepatology (Baltimore, Md.) 2012;56(2):411-4.
2012: Wan-Shoo Cheong; Michiko Hyakumura; Stephen Locarnini; Nadia Warner; Lilly Yuen; Hans J Netter
Modulation of the immunogenicity of virus-like particles composed of mutant hepatitis B virus envelope subunits.
Antiviral research 2012;93(2):209-18.
2012: Alexander J Thompson; Stephen Locarnini
Direct-acting antiviral agents for the treatment of HCV.
Antiviral therapy 2012;17(6 Pt B):1105-7.
2012: Anchalee Avihingsanon; Scott Bowden; David A Cooper; Greg J Dore; Sharon R Lewin; Stephen Locarnini; Pip Marks; Gail V Matthews; Jose Sasadeusz; Kiat Ruxrungtham
Assessment of HBV flare in a randomized clinical trial in HIV/HBV coinfected subjects initiating HBV-active antiretroviral therapy in Thailand.
AIDS research and therapy 2012;9(1):6.
2011: Henry Lik-Yuen Chan; Markus Cornberg; Harry L A Janssen; Ji-Dong Jia; Jia-Horng Kao; Stephen Locarnini; Michelle Martinot-Peignoux; Teerha Piratvisuth; Alex Thompson; Hans L Tillmann; Heiner Wedemeyer; Maurizia Rossana Brunetto; Patrick Marcellin
Hepatitis B surface antigen quantification: why and how to use it in 2011 - a core group report.
Journal of hepatology 2011;55(5):1121-31.
2011: Renae Walsh; Stewart Nuttall; Peter Revill; Danni Colledge; Liza Cabuang; Sally Soppe; Olan Dolezal; Kate Griffiths; Angeline Bartholomeusz; Stephen Locarnini
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody.
Virology 2011;411(1):132-41.
2011: Jennifer Audsley; Anchalee Avihingsanon; Gregory J Dore; Kit Fairley; Robert Finlayson; Hyon S Hwang; Margaret Littlejohn; Stephen Locarnini; Gail V Matthews; Kiat Ruxrungtham; Joseph Sasadeusz; Eric C Seaberg; Chloe L Thio; Sharon R Lewin
Factors associated with elevated ALT in an international HIV/HBV co-infected cohort on long-term HAART.
PloS one 2011;6(11):e26482.
2010: Stephen Locarnini
Transmission of antiviral drug resistant hepatitis B virus: implications for public health and patient management.
Journal of gastroenterology and hepatology 2010;25(4):649-51.
2010: Stephen Locarnini; Fabien Zoulim
Molecular genetics of HBV infection.
Antiviral therapy 2010;15 Suppl 3():3-14.
2010: Peter Revill; Lilly Yuen; Renae Walsh; Marie Perrault; Stephen Locarnini; Anna Kramvis
Bioinformatic analysis of the hepadnavirus e-antigen and its precursor identifies remarkable sequence conservation in all orthohepadnaviruses.
Journal of medical virology 2010;82(1):104-15.
2009: Gail V Matthews; Eric C Seaberg; Gregory J Dore; Scott Bowden; Sharon R Lewin; Joe Sasadeusz; Pip Marks; Zachary Goodman; FRANCES PHILP; Yiwei Tang; Stephen Locarnini; Chloe L Thio
Combination HBV therapy is linked to greater HBV DNA suppression in a cohort of lamivudine-experienced HIV/HBV coinfected individuals.
AIDS (London, England) 2009;23(13):1707-15.
2009: Saleem Kamili; Vitini Sozzi; Geoff Thompson; Katie Campbell; Christopher M Walker; Stephen Locarnini; Krzysztof Krawczynski
Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model.
Hepatology (Baltimore, Md.) 2009;49(5):1483-91.
2009: Alex J Thompson; Danni Colledge; Sally Rodgers; Rachel Wilson; Peter Revill; Paul Desmond; Ashley Mansell; Kumar Visvanathan; Stephen Locarnini
Stimulation of the interleukin-1 receptor and Toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro.
Antiviral therapy 2009;14(6):797-808.
2009: Nadia Warner; Stephen Locarnini
Can antiviral therapy for chronic hepatitis B enhance the progression to hepatocellular carcinoma?
Antiviral therapy 2009;14(2):139-42.
2008: Gail V Matthews; Anchalee Avihingsanon; Sharon R Lewin; Janaki Amin; Rungsun Rerknimitr; Panusit Petcharapirat; Pip Marks; Joe Sasadeusz; David A Cooper; Scott Bowden; Stephen Locarnini; Kiat Ruxrungtham; Gregory J Dore
A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in Thailand.
Hepatology (Baltimore, Md.) 2008;48(4):1062-9.
2008: Scott Preiss; Margaret Littlejohn; Peter W Angus; Alex Thompson; Paul Desmond; Sharon R Lewin; Joseph Sasadeusz; Gail Matthews; Gregory J Dore; Tim Shaw; Vitini Sozzi; Lilly Yuen; George Lau; Anna Ayres; Chloe L Thio; Anchalee Avihingsanon; Kiat Ruxrungtham; Stephen Locarnini; Peter Andrew Revill
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Hepatology (Baltimore, Md.) 2008;48(3):741-9.
2008: Nadia Warner; Stephen Locarnini
The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound.
Hepatology (Baltimore, Md.) 2008;48(1):88-98.
2008: Joseph J Y Sung; Stephen K W Tsui; Chi-Hang Tse; Eddie Y T Ng; Kwok-Sui Leung; Kin-Hong Lee; Tony Shu Kam Mok; Angeline Bartholomeusz; Thomas C C Au; Kelvin K F Tsoi; Stephen Locarnini; Henry Lik-Yuen Chan
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
Journal of virology 2008;82(7):3604-11.
2007: Nadia Warner; Stephen Locarnini; Michael Kuiper; Angeline Bartholomeusz; Anna Ayres; Lilly Yuen; Tim Shaw
The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Antimicrobial agents and chemotherapy 2007;51(7):2285-92.
2007: Kumar Visvanathan; Narelle A Skinner; Alex J V Thompson; Stephen M Riordan; Vitini Sozzi; Roslyn Edwards; Sally Rodgers; Jelica Kurtovic; Judy Chang; Sharon Lewin; Paul Desmond; Stephen Locarnini
Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein.
Hepatology (Baltimore, Md.) 2007;45(1):102-10.
2006: Stephen M Riordan; Narelle A Skinner; Jelica Kurtovic; Stephen Locarnini; Kumar Visvanathan
Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B.
Clinical and vaccine immunology : CVI 2006;13(8):972-4.
2006: Stephen M Riordan; Narelle A Skinner; Jelica Kurtovic; Stephen Locarnini; Christopher J McIver; Roger Williams; Kumar Visvanathan
Toll-like receptor expression in chronic hepatitis C: correlation with pro-inflammatory cytokine levels and liver injury.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55(7):279-85.
2006: Gail V Matthews; Angeline Bartholomeusz; Stephen Locarnini; Anna Ayres; Joe Sasaduesz; Eric C Seaberg; David A Cooper; Sharon Lewin; Gregory J Dore; Chloe L Thio
Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy.
AIDS (London, England) 2006;20(6):863-70.
2006: Tim Shaw; Angeline Bartholomeusz; Stephen Locarnini
HBV drug resistance: mechanisms, detection and interpretation.
Journal of hepatology 2006;44(3):593-606.
2006: Seng Gee Lim; Chun-Tao Wai; Yin Mei Lee; Yock Young Dan; Dede Selamat Sutedja; Aileen Wee; Shirley Suresh; Ying Juan Wu; David Machin; Chee Chian Lim; Kwong Ming Fock; Evelyn Koay; Scott Bowden; Stephen Locarnini; Shamsuddin Mohammed Ishaque
A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B.
Antiviral therapy 2006;11(2):245-53.
2005: Henry Lik-Yuen Chan; Stephen Kwok-Wing Tsui; Chi-Hang Tse; Eddie Y T Ng; Thomas C C Au; Lilly Yuen; Angeline Bartholomeusz; Kwok-Sui Leung; Kin-Hong Lee; Stephen Locarnini; Joseph J Y Sung
Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C.
The Journal of infectious diseases 2005;191(12):2022-32.
2005: Joseph J Y Sung; May-Ling Wong; Scott Bowden; Choong-Tsek Liew; Alex Yui Hui; Vincent Wong; Nancy Wai-Yee Leung; Stephen Locarnini; Henry Lik-Yuen Chan
Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy.
Gastroenterology 2005;128(7):1890-7.
2005: Stephen Locarnini; Tim Shaw; J Dean; Danni Colledge; A Thompson; K Li; S M Lemon; G G K Lau; M R Beard
Cellular response to conditional expression of the hepatitis B virus precore and core proteins in cultured hepatoma (Huh-7) cells.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;32(2):113-21.
2005: Stephen Locarnini
Molecular virology and the development of resistant mutants: implications for therapy.
Seminars in liver disease 2005;25 Suppl 1():9-19.
2004: Tim Shaw; Stephen Locarnini
Entecavir for the treatment of chronic hepatitis B.
Expert review of anti-infective therapy 2004;2(6):853-71.
2004: Stephen Locarnini; Angelos Hatzakis; Jenny Heathcote; Emmet B Keeffe; TSANYANG LIANG; David Mutimer; Jean-Michel Pawlotsky; Fabien Zoulim
Management of antiviral resistance in patients with chronic hepatitis B.
Antiviral therapy 2004;9(5):679-93.
2004: Daniel J Tenney; Steven M Levine; Ronald E Rose; Ann W Walsh; Steve Weinheimer; Linda F Discotto; Mary Jane Plym; Kevin A Pokornowski; Cheng-Fang Yu; Peter W Angus; Anna Ayres; Angeline Bartholomeusz; William Sievert; G Thompson; Nadia Warner; Stephen Locarnini; Richard J Colonno
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
Antimicrobial agents and chemotherapy 2004;48(9):3498-507.
2004: Fiona Wightman; Tomos Walters; Anna Ayres; Scott Bowden; Angeline Bartholomeusz; Daryl Lau; Stephen Locarnini; Sharon R Lewin
Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strains.
Journal of clinical microbiology 2004;42(8):3809-12.
2004: Bettina Werle-Lapostolle; Scott Bowden; Stephen Locarnini; Karsten Wursthorn; Jörg Petersen; George Lau; Christian Trepo; Patrick Marcellin; Zachary D Goodman; William E Delaney; Shelly Xiong; Carol L Brosgart; Shan-Shan Chen; Craig S Gibbs; Fabien Zoulim
Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.
Gastroenterology 2004;126(7):1750-8.
2004: Jia-Yee Lee; Stephen Locarnini
Hepatitis B virus: pathogenesis, viral intermediates, and viral replication.
Clinics in liver disease 2004;8(2):301-20.
2004: Anna Ayres; Stephen Locarnini; Angeline Bartholomeusz
HBV genotyping and analysis for unique mutations.
Methods in molecular medicine 2004;95():125-49.
2004: Scott Bowden; Kathy Jackson; Margaret Littlejohn; Stephen Locarnini
Quantification of HBV covalently closed circular DNA from liver tissue by real-time PCR.
Methods in molecular medicine 2004;95():41-50.
2004: Tim Shaw; Stephen Locarnini
A parsimonious method for screening drug combinations for antihepadnaviral activity using a parametric dose-response surface approach.
Methods in molecular medicine 2004;96():387-413.
2004: Tim Shaw; Scott Bowden; Stephen Locarnini
Rescue therapy for drug resistant hepatitis B: another argument for combination chemotherapy?
Gastroenterology 2004;126(1):343-7.
2003: Peter W Angus; Rhys Vaughan; Shelly Xiong; Huiling Yang; William E Delaney; Craig Gibbs; Carol L Brosgart; Danni Colledge; Rosalind Edwards; Anna Ayres; Angeline Bartholomeusz; Stephen Locarnini
Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Gastroenterology 2003;125(2):292-7.
2003: Louise Cooley; Anna Ayres; Angeline Bartholomeusz; Sharon Lewin; Suzanne Crowe; Anne Mijch; Stephen Locarnini; Joseph Sasadeusz
Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals.
AIDS (London, England) 2003;17(11):1649-57.
2003: Christian Klein; C-Thomas Bock; Heiner Wedemeyer; Torsten Wüstefeld; Stephen Locarnini; Hans P Dienes; Stefan Kubicka; Michael P Manns; Christian Trautwein
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.
Gastroenterology 2003;125(1):9-18.
2003: Anna Ayres; Angeline Bartholomeusz; George Lau; Kui-Chan Lam; Jia-Yee Lee; Stephen Locarnini
Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2003;27(1):111-6.
2003: Scott Bowden; Angeline Bartholomeusz; Stephen Locarnini
Lamivudine resistant occult HBV: implications for public health?
Journal of hepatology 2003;38(4):526-8.
2003: Stephen Locarnini; Janine McMillan; Angeline Bartholomeusz
The hepatitis B virus and common mutants.
Seminars in liver disease 2003;23(1):5-20.
2003: Stephen Locarnini
Hepatitis B viral resistance: mechanisms and diagnosis.
Journal of hepatology 2003;39 Suppl 1():S124-32.
2002: Tim Shaw; Scott Bowden; Stephen Locarnini
Chemotherapy for hepatitis B: new treatment options necessitate reappraisal of traditional endpoints.
Gastroenterology 2002;123(6):2135-40.
2002: Sharon Lewin; Tomos Walters; Stephen Locarnini
Hepatitis B treatment: rational combination chemotherapy based on viral kinetic and animal model studies.
Antiviral research 2002;55(3):381-96.
2002: William E Delaney; Ros Edwards; Danni Colledge; Tim Shaw; Phil Furman; George Painter; Stephen Locarnini
Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro.
Antimicrobial agents and chemotherapy 2002;46(9):3057-60.
2002: William Sievert; Stephen Pianko; Shernyne Warner; Scott Bowden; Ian Simpson; Don Bowden; Stephen Locarnini
Hepatic iron overload does not prevent a sustained virological response to interferon-alpha therapy: a long term follow-up study in hepatitis C-infected patients with beta thalassemia major.
The American journal of gastroenterology 2002;97(4):982-7.
2002: C-Thomas Bock; Hans L Tillmann; Joseph Torresi; Jürgen Klempnauer; Stephen Locarnini; Michael P Manns; Christian Trautwein
Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation.
Gastroenterology 2002;122(2):264-73.
2002: Maurizio Bonacini; Alan Kurz; Stephen Locarnini; Anna Ayres; Craig Gibbs
Fulminant hepatitis B due to a lamivudine-resistant mutant of HBV in a patient coinfected with HIV.
Gastroenterology 2002;122(1):244-5.
2001: Richard J Colonno; Eugene V Genovesi; Ivette Medina; Lucinda Lamb; S K Durham; M L Huang; L Corey; Margaret Littlejohn; Stephen Locarnini; B C Tennant; B Rose; JM Clark
Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection.
The Journal of infectious diseases 2001;184(10):1236-45.
2001: Sharon R Lewin; Ruy M Ribeiro; Tomos Walters; G K Lau; Scott Bowden; Stephen Locarnini; A S Perelson
Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed.
Hepatology (Baltimore, Md.) 2001;34(5):1012-20.
2001: Ruth Chin; Tim Shaw; Joseph Torresi; Vitini Sozzi; C Trautwein; T Bock; M Manns; Harriet C Isom; P Furman; Stephen Locarnini
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Antimicrobial agents and chemotherapy 2001;45(9):2495-501.
2001: Jia-Yee Lee; J G Culvenor; Peter W Angus; RA Smallwood; AJ Nicoll; Stephen Locarnini
Duck hepatitis B virus replication in primary bile duct epithelial cells.
Journal of virology 2001;75(16):7651-61.
2001: William E Delaney; Ros Edwards; Danni Colledge; Tim Shaw; Joseph Torresi; Thomas G Miller; Harriet C Isom; C-Thomas Bock; M P Manns; C Trautwein; Stephen Locarnini
Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus.
Antimicrobial agents and chemotherapy 2001;45(6):1705-13.
2001: C-Thomas Bock; S Schwinn; Stephen Locarnini; J Fyfe; Michael P Manns; Christian Trautwein; H Zentgraf
Structural organization of the hepatitis B virus minichromosome.
Journal of molecular biology 2001;307(1):183-96.
2001: William E Delaney; Stephen Locarnini; Tim Shaw
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.
Antiviral chemistry & chemotherapy 2001;12(1):1-35.
2000: Stephen Locarnini
Molecular pathogenesis of viral hepatitis.
Journal of gastroenterology and hepatology 2000;15 Suppl():G46-8.
2000: AJ Nicoll; Stephen Locarnini; S T Chou; RA Smallwood; Peter W Angus
Effect of nucleoside analogue therapy on duck hepatitis B viral replication in hepatocytes and bile duct epithelial cells in vivo.
Journal of gastroenterology and hepatology 2000;15(3):304-10.
2000: Danni Colledge; G Civitico; Stephen Locarnini; Tim Shaw
In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir.
Antimicrobial agents and chemotherapy 2000;44(3):551-60.
2000: Joseph Torresi; Stephen Locarnini
Antiviral chemotherapy for the treatment of hepatitis B virus infections.
Gastroenterology 2000;118(2 Suppl 1):S83-103.
1999: Dae-Kee Kim; Namkyu Lee; DH Ryu; YW Kim; JS Kim; K Chang; GJ Im; WS Choi; Y B Cho; KH Kim; Danni Colledge; Stephen Locarnini
Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1- yl)purines as potential prodrugs of penciclovir.
Bioorganic & medicinal chemistry 1999;7(8):1715-25.
1999: Stephen Locarnini; C Birch
Antiviral chemotherapy for chronic hepatitis B infection: lessons learned from treating HIV-infected patients.
Journal of hepatology 1999;30(3):536-50.
1998: E Lin; C Luscombe; Danni Colledge; Y Y Wang; Stephen Locarnini
Long-term therapy with the guanine nucleoside analog penciclovir controls chronic duck hepatitis B virus infection in vivo.
Antimicrobial agents and chemotherapy 1998;42(8):2132-7.
1998: Margaret Littlejohn; Stephen Locarnini; Angeline Bartholomeusz
Targets for inhibition of hepatitis C virus replication.
Antiviral therapy 1998;3(Suppl 3):83-91.
1997: AJ Nicoll; Stephen Locarnini
Review: Present and future directions in the treatment of chronic hepatitis B infection.
Journal of gastroenterology and hepatology 1997;12(12):843-54.
1997: Danni Colledge; Stephen Locarnini; Tim Shaw
Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro.
Hepatology (Baltimore, Md.) 1997;26(1):216-25.
1997: T T Aye; Angeline Bartholomeusz; Tim Shaw; Scott Bowden; Alan M Breschkin; J McMillan; Peter W Angus; Stephen Locarnini
Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation.
Journal of hepatology 1997;26(5):1148-53.