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David Lockhart

Research Profile

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Oligonucleotide Array Sequence Analysis

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Anatomy

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Publications

TOP 3
Lynn Bekris; N M Galloway; S Millard; David J Lockhart; Ge Li; Douglas Galasko; Martin R Farlow; Christopher M Clark; Joseph F Quinn; Jeffrey A Kaye; Gerard D Schellenberg; James B Leverenz; Peter Seubert; Debby W Tsuang; Elaine Peskind; Chang-En Yu
Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.
Hitesh K Patel; Robert M Grotzfeld; Andiliy G Lai; Shamal A Mehta; Zdravko V Milanov; Qi Chao; Kelly G Sprankle; Todd A Carter; Anne Marie Velasco; Miles A Fabian; Joyce James; Daniel K Treiber; David J Lockhart; Patrick P Zarrinkar; Shripad S Bhagwat
Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.
Mazen W Karaman; Sanna Herrgard; Daniel K Treiber; Paul Gallant; Corey E Atteridge; Brian T Campbell; Katrina W Chan; Pietro Ciceri; Mindy I Davis; Philip T Edeen; Raffaella Faraoni; Mark Floyd; Jeremy P Hunt; David J Lockhart; Zdravko V Milanov; Michael J Morrison; Gabriel Pallares; Hitesh K Patel; Stephanie Pritchard; Lisa M Wodicka; Patrick P Zarrinkar
A quantitative analysis of kinase inhibitor selectivity.

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All Publications

2011: Lynn Bekris; N M Galloway; S Millard; David J Lockhart; Ge Li; Douglas Galasko; Martin R Farlow; Christopher M Clark; Joseph F Quinn; Jeffrey A Kaye; Gerard D Schellenberg; James B Leverenz; Peter Seubert; Debby W Tsuang; Elaine Peskind; Chang-En Yu
Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.
Neurobiology of aging 2011;32(3):556.e13-23.
2009: Hitesh K Patel; Robert M Grotzfeld; Andiliy G Lai; Shamal A Mehta; Zdravko V Milanov; Qi Chao; Kelly G Sprankle; Todd A Carter; Anne Marie Velasco; Miles A Fabian; Joyce James; Daniel K Treiber; David J Lockhart; Patrick P Zarrinkar; Shripad S Bhagwat
Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(17):5182-5.
2008: Mazen W Karaman; Sanna Herrgard; Daniel K Treiber; Paul Gallant; Corey E Atteridge; Brian T Campbell; Katrina W Chan; Pietro Ciceri; Mindy I Davis; Philip T Edeen; Raffaella Faraoni; Mark Floyd; Jeremy P Hunt; David J Lockhart; Zdravko V Milanov; Michael J Morrison; Gabriel Pallares; Hitesh K Patel; Stephanie Pritchard; Lisa M Wodicka; Patrick P Zarrinkar
A quantitative analysis of kinase inhibitor selectivity.
Nature biotechnology 2008;26(1):127-32.
2007: Jennifer A Greenhall; Matthew A Zapala; Mario Cáceres; Ondrej Libiger; Carrolee Barlow; Nicholas J Schork; David J Lockhart
Detecting genetic variation in microarray expression data.
Genome research 2007;17(8):1228-35.
2007: Iiris Hovatta; Matthew A Zapala; Ron S Broide; Eric E Schadt; Ondrej Libiger; Nicholas J Schork; David J Lockhart; Carrolee Barlow
DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies.
Genome biology 2007;8(2):R25.
2006: Matthew Adam Young; Neil P Shah; Luke H Chao; Markus Seeliger; Zdravko V Milanov; William H Biggs; Daniel K Treiber; Hitesh K Patel; Patrick P Zarrinkar; David J Lockhart; Charles L Sawyers; John Kuriyan
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer research 2006;66(2):1007-14.
2005: Iiris Hovatta; Richard S Tennant; Robert Helton; Robert Marr; Oded Singer; Jeffrey M Redwine; Julie A Ellison; Eric E Schadt; Inder M Verma; David J Lockhart; Carrolee Barlow
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.
Nature 2005;438(7068):662-6.
2005: Christopher J Winrow; Daniel G Pankratz; Cecile Rose T Vibat; Timothy Bowen; Marie A Callahan; Amy J Warren; Brian S Hilbush; Anthony Wynshaw-Boris; Chuck Hasel; Zoë Weaver; David J Lockhart; Carrolee Barlow
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
Human molecular genetics 2005;14(18):2671-84.
2005: Todd A Carter; Lisa M Wodicka; Neil P Shah; Anne Marie Velasco; Miles A Fabian; Daniel K Treiber; Zdravko V Milanov; Corey E Atteridge; William H Biggs; Philip T Edeen; Mark Floyd; Julia M Ford; Robert M Grotzfeld; Sanna Herrgard; Darren E Insko; Shamal A Mehta; Hitesh K Patel; William Pao; Charles L Sawyers; Harold Varmus; Patrick P Zarrinkar; David J Lockhart
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11011-6.
2005: Matthew A Zapala; Iiris Hovatta; Julie A Ellison; Lisa M Wodicka; Jo A Del Rio; Richard Tennant; Wendy Tynan; Ron S Broide; Robert Helton; Barbara S Stoveken; Christopher J Winrow; Daniel J Lockhart; John F Reilly; Warren G Young; Floyd E Bloom; David J Lockhart; Carrolee Barlow
Adult mouse brain gene expression patterns bear an embryologic imprint.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10357-62.
2005: Miles A Fabian; William H Biggs; Daniel K Treiber; Corey E Atteridge; Mihai D Azimioara; Michael G Benedetti; Todd A Carter; Pietro Ciceri; Philip T Edeen; Mark Floyd; Julia M Ford; Margaret Galvin; Jay L Gerlach; Robert M Grotzfeld; Sanna Herrgard; Darren E Insko; Michael A Insko; Andiliy G Lai; Jean-Michel Lélias; Shamal A Mehta; Zdravko V Milanov; Anne Marie Velasco; Lisa M Wodicka; Hitesh K Patel; Patrick P Zarrinkar; David J Lockhart
A small molecule-kinase interaction map for clinical kinase inhibitors.
Nature biotechnology 2005;23(3):329-36.
2005: Todd A Carter; Jennifer A Greenhall; Shigeo Yoshida; Sebastian Fuchs; Robert Helton; Anand Swaroop; David J Lockhart; Carrolee Barlow
Mechanisms of aging in senescence-accelerated mice.
Genome biology 2005;6(6):R48.
2003: Mario Cáceres; Joel Lachuer; Matthew A Zapala; John C Redmond; Lili C Kudo; Daniel Geschwind; David J Lockhart; Todd M Preuss; Carrolee Barlow
Elevated gene expression levels distinguish human from non-human primate brains.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13030-5.
2002: Carrolee Barlow; David J Lockhart
DNA arrays and neurobiology--what's new and what's next?
Current opinion in neurobiology 2002;12(5):554-61.
2002: Guy Oshiro; Lisa M Wodicka; Michael Washburn; John R Yates; David J Lockhart; Elizabeth A Winzeler
Parallel identification of new genes in Saccharomyces cerevisiae.
Genome research 2002;12(8):1210-20.
2002: Matthew A Zapala; David J Lockhart; Daniel G Pankratz; Anthony J Garcia; Carrolee Barlow; David J Lockhart
Software and methods for oligonucleotide and cDNA array data analysis.
Genome biology 2002;3(6):SOFTWARE0001.
2001: Mosur K Raghuraman; Elizabeth A Winzeler; David Collingwood; S Hunt; Lisa M Wodicka; AR Conway; David J Lockhart; Ronald W Davis; Bonita J Brewer; Walton L Fangman
Replication dynamics of the yeast genome.
Science (New York, N.Y.) 2001;294(5540):115-21.
2001: Todd A Carter; Jo A Del Rio; Jennifer A Greenhall; M L Latronica; David J Lockhart; Carrolee Barlow
Chipping away at complex behavior: transcriptome/phenotype correlations in the mouse brain.
Physiology & behavior 2001;73(5):849-57.
2001: Patrick P Zarrinkar; Jim Mainquist; M Zamora; D Stern; John B Welsh; Lisa M Sapinoso; Garret M Hampton; David J Lockhart
Arrays of arrays for high-throughput gene expression profiling.
Genome research 2001;11(7):1256-61.
2001: John B Welsh; Patrick P Zarrinkar; Lisa M Sapinoso; Suzanne G Kern; cynthia behling; B J Monk; David J Lockhart; R A Burger; Garret M Hampton
Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1176-81.
2001: RJ Cho; Mingxia Huang; M J Campbell; H Dong; Lars M Steinmetz; Lisa M Sapinoso; G Hampton; S J Elledge; Ronald W Davis; David J Lockhart
Transcriptional regulation and function during the human cell cycle.
Nature genetics 2001;27(1):48-54.
2000: C Rampon; C H Jiang; H Dong; Ya-Ping Tang; David J Lockhart; Peter G Schultz; Joseph Zhuo Tsien; Yanan Hu
Effects of environmental enrichment on gene expression in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12880-4.
2000: R Sandberg; R Yasuda; Daniel G Pankratz; Todd A Carter; Jo A Del Rio; Lisa M Wodicka; Mark Mayford; David J Lockhart; Carrolee Barlow
Regional and strain-specific gene expression mapping in the adult mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):11038-43.
2000: David J Lockhart; Elizabeth A Winzeler
Genomics, gene expression and DNA arrays.
Nature 2000;405(6788):827-36.
1999: Stanley Fields; Y Kohara; David J Lockhart
Functional genomics.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):8825-6.
1998: Elizabeth A Winzeler; Daniel R Richards; AR Conway; Alan L Goldstein; Sue Kalman; Michael J McCullough; John H McCusker; David A Stevens; Lisa M Wodicka; David J Lockhart; Ronald W Davis
Direct allelic variation scanning of the yeast genome.
Science (New York, N.Y.) 1998;281(5380):1194-7.
1998: Nathanael S Gray; Lisa M Wodicka; A M Thunnissen; T C Norman; S Kwon; FH Espinoza; David O Morgan; G Barnes; S LeClerc; L Meijer; Sung-Huo S H Kim; David J Lockhart; Peter G Schultz
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science (New York, N.Y.) 1998;281(5376):533-8.
1998: RJ Cho; M J Campbell; Elizabeth A Winzeler; Lars M Steinmetz; AR Conway; Lisa M Wodicka; Tyra G Wolfsberg; AE Gabrielian; David Landsman; David J Lockhart; Ronald W Davis
A genome-wide transcriptional analysis of the mitotic cell cycle.
Molecular cell 1998;2(1):65-73.
1998: RJ Cho; Micheline Fromont-Racine; Lisa M Wodicka; Becket Feierbach; Tim Stearns; Pierre Legrain; David J Lockhart; Ronald W Davis
Parallel analysis of genetic selections using whole genome oligonucleotide arrays.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3752-7.
1997: Lisa M Wodicka; H Dong; M Mittmann; M H Ho; David J Lockhart
Genome-wide expression monitoring in Saccharomyces cerevisiae.
Nature biotechnology 1997;15(13):1359-67.
1988: David J Lockhart; Steven G Boxer
Stark effect spectroscopy of Rhodobacter sphaeroides and Rhodopseudomonas viridis reaction centers.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(1):107-11.