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Jeffrey Lockman

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TOP 3
Praveen Kumar Suryadevara; Srinivas Olepu; Jeffrey W Lockman; Junko Ohkanda; Mandana Karimi; Christophe Verlinde; James M Kraus; Jan Schoepe; Wesley C Van Voorhis; Andrew D Hamilton; Frederick S Buckner; Michael H Gelb
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Junko Ohkanda; Corey L Strickland; Michelle A Blaskovich; Dora Carrico; Jeffrey W Lockman; Andreas Vogt; Cynthia J Bucher; Jiazhi Sun; Yimin Qian; David Knowles; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Jeffrey W Lockman; Andrew D Hamilton
Recent developments in the identification of chemotherapeutics for Chagas disease.

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All Publications

2009: Praveen Kumar Suryadevara; Srinivas Olepu; Jeffrey W Lockman; Junko Ohkanda; Mandana Karimi; Christophe Verlinde; James M Kraus; Jan Schoepe; Wesley C Van Voorhis; Andrew D Hamilton; Frederick S Buckner; Michael H Gelb
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Journal of medicinal chemistry 2009;52(12):3703-15.
2006: Junko Ohkanda; Corey L Strickland; Michelle A Blaskovich; Dora Carrico; Jeffrey W Lockman; Andreas Vogt; Cynthia J Bucher; Jiazhi Sun; Yimin Qian; David Knowles; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
2005: Jeffrey W Lockman; Andrew D Hamilton
Recent developments in the identification of chemotherapeutics for Chagas disease.
Current medicinal chemistry 2005;12(8):945-59.
2004: Junko Ohkanda; Frederick S Buckner; Jeffrey W Lockman; Kohei Yokoyama; Dora Carrico; Richard Eastman; Kate de Luca-Fradley; Wendy Davies; Simon L Croft; Wesley C Van Voorhis; Michael H Gelb; Said M Sebti; Andrew D Hamilton
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2003: Frederick S Buckner; Kohei Yokoyama; Jeffrey W Lockman; Kendra Aikenhead; Junko Ohkanda; Martin Sadilek; Said Sebti; Wesley C Van Voorhis; Andrew Hamilton; Michael H Gelb
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15149-53.
2002: Junko Ohkanda; Jeffrey W Lockman; Mohit A Kothare; Yimin Qian; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Journal of medicinal chemistry 2002;45(1):177-88.
2001: Junko Ohkanda; Jeffrey W Lockman; Kohei Yokoyama; Michael H Gelb; Simon L Croft; H Kendrick; M I Harrell; JE Feagin; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.