Oksana Lockridge

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Physiology

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Grigoryan Hasmik; Li Bin; Xue Weihua; Grigoryan Marine; Schopfer Lawrence M; Lockridge Oksana
Mass spectral characterization of organophosphate-labeled lysine in peptides.
Gilley Cynthia; MacDonald Mary; Nachon Florian; Schopfer Lawrence M; Zhang Jun; Cashman John R; Lockridge Oksana
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
Grigoryan Hasmik; Schopfer Lawrence M; Peeples Eric S; Duysen Ellen G; Grigoryan Marine; Thompson Charles M; Lockridge Oksana
Mass spectrometry identifies multiple organophosphorylated sites on tubulin.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Oksana Lockridge (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Grigoryan Hasmik; Li Bin; Xue Weihua; Grigoryan Marine; Schopfer Lawrence M; Lockridge Oksana
Mass spectral characterization of organophosphate-labeled lysine in peptides.
Analytical biochemistry 2009;394(1):92-100.
2009: Gilley Cynthia; MacDonald Mary; Nachon Florian; Schopfer Lawrence M; Zhang Jun; Cashman John R; Lockridge Oksana
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
Chemical research in toxicology 2009;22(10):1680-8.
2009: Grigoryan Hasmik; Schopfer Lawrence M; Peeples Eric S; Duysen Ellen G; Grigoryan Marine; Thompson Charles M; Lockridge Oksana
Mass spectrometry identifies multiple organophosphorylated sites on tubulin.
Toxicology and applied pharmacology 2009;240(2):149-58.
2009: Grigoryan Hasmik; Lockridge Oksana
Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.
Toxicology and applied pharmacology 2009;240(2):143-8.
2009: Chilukuri Nageswararao; Duysen Ellen G; Parikh Kalpana; diTargiani Robert; Doctor Bhupendra P; Lockridge Oksana; Saxena Ashima
Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.
Molecular pharmacology 2009;76(3):612-7.
2009: Grigoryan Hasmik; Li Bin; Anderson Erica K; Xue Weihua; Nachon Florian; Lockridge Oksana; Schopfer Lawrence M
Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine.
Chemico-biological interactions 2009;180(3):492-8.
2009: Johnson Noel D; Duysen Ellen G; Lockridge Oksana
Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain.
Neurotoxicology 2009;30(3):386-92.
2009: Duysen Ellen G; Li Bin; Lockridge Oksana
The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease.
Expert opinion on drug metabolism & toxicology 2009;5(5):523-8.
2009: Li He; Ricordel Ivan; Tong Larry; Schopfer Lawrence M; Baud Frédéric; Mégarbane Bruno; Maury Eric; Masson Patrick; Lockridge Oksana
Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum.
Journal of applied toxicology : JAT 2009;29(2):149-55.
2009: Naik Runa S; Hartmann Joachim; Kiewert Cornelia; Duysen Ellen G; Lockridge Oksana; Klein Jochen
Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2009;12(1):79-85.
2008: Duysen Ellen G; Li Bin; Carlson Michaela; Li Yi-Fan; Wieseler Stacy; Hinrichs Steven H; Lockridge Oksana
Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice.
Basic & clinical pharmacology & toxicology 2008;103(6):514-21.
2008: Carletti Eugénie; Li He; Li Bin; Ekström Fredrik; Nicolet Yvain; Loiodice Mélanie; Gillon Emilie; Froment Marie T; Lockridge Oksana; Schopfer Lawrence M; Masson Patrick; Nachon Florian
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.
Journal of the American Chemical Society 2008;130(47):16011-20.
2008: Ding Shi-Jian; Carr John; Carlson James E; Tong Larry; Xue Weihua; Li Yifeng; Schopfer Lawrence M; Li Bin; Nachon Florian; Asojo Oluwatoyin; Thompson Charles M; Hinrichs Steven H; Masson Patrick; Lockridge Oksana
Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Chemical research in toxicology 2008;21(9):1787-94.
2008: Li He; Tong Larry; Schopfer Lawrence M; Masson Patrick; Lockridge Oksana
Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase.
Chemico-biological interactions 2008;175(1-3):68-72.
2008: Masson Patrick; Nachon Florian; Broomfield Clarence A; Lenz David E; Verdier Laurent; Schopfer Lawrence M; Lockridge Oksana
A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.
Chemico-biological interactions 2008;175(1-3):273-80.
2008: Grigoryan Hasmik; Schopfer Lawrence M; Thompson Charles M; Terry Alvin V; Masson Patrick; Lockridge Oksana
Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.
Chemico-biological interactions 2008;175(1-3):180-6.
2008: Chilukuri Nageswararao; Duysen Ellen G; Parikh Kalpana; Sun Wei; Doctor Bhupendra P; Lockridge Oksana; Saxena Ashima
Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo.
Chemico-biological interactions 2008;175(1-3):327-31.
2008: Duysen Ellen G; Lockridge Oksana
Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.
Chemico-biological interactions 2008;175(1-3):119-24.
2008: Li Bin; Duysen Ellen G; Lockridge Oksana
The butyrylcholinesterase knockout mouse is obese on a high-fat diet.
Chemico-biological interactions 2008;175(1-3):88-91.
2008: Lockridge Oksana; Xue Weihua; Gaydess Andrea; Grigoryan Hasmik; Ding Shi-Jian; Schopfer Lawrence M; Hinrichs Steven H; Masson Patrick
Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines.
The Journal of biological chemistry 2008;283(33):22582-90.
2008: Darvesh Sultan; Darvesh Katherine V; McDonald Robert S; Mataija Diane; Walsh Ryan; Mothana Sam; Lockridge Oksana; Martin Earl
Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Journal of medicinal chemistry 2008;51(14):4200-12.
2008: Masson Patrick; Froment Marie-Thérèse; Gillon Emilie; Nachon Florian; Lockridge Oksana; Schopfer Lawrence M
Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters.
The FEBS journal 2008;275(10):2617-31.
2008: Hartmann Joachim; Kiewert Cornelia; Duysen Ellen G; Lockridge Oksana; Klein Jochen
Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice.
Neurochemistry international 2008;52(6):972-8.
2008: Li He; Schopfer Lawrence M; Masson Patrick; Lockridge Oksana
Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers.
The Biochemical journal 2008;411(2):425-32.
2008: Mikami Liya R; Wieseler Stacy; Souza Ricardo L R; Schopfer Lawrence M; Nachon Florian; Lockridge Oksana; Chautard-Freire-Maia Eleidi A
Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.
Pharmacogenetics and genomics 2008;18(3):213-8.
2008: Li Bin; Duysen Ellen G; Carlson Michaela; Lockridge Oksana
The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1146-54.
2008: Li Bin; Nachon Florian; Froment Marie-Thérèse; Verdier Laurent; Debouzy Jean-Claude; Brasme Bernardo; Gillon Emilie; Schopfer Lawrence M; Lockridge Oksana; Masson Patrick
Binding and hydrolysis of soman by human serum albumin.
Chemical research in toxicology 2008;21(2):421-31.
2007: Li He; Schopfer Lawrence M; Nachon Florian; Froment Marie-Thérèse; Masson Patrick; Lockridge Oksana
Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):136-45.
2007: Myslivecek Jaromir; Duysen Ellen G; Lockridge Oksana
Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice.
Naunyn-Schmiedeberg's archives of pharmacology 2007;376(1-2):83-92.
2007: Ngamelue Michelle N; Homma Kohei; Lockridge Oksana; Asojo Oluwatoyin A
Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 9):723-7.
2007: Mikami Liya R; Wieseler Stacy; Souza Ricardo L R; Schopfer Lawrence M; Lockridge Oksana; Chautard-Freire-Maia Eleidi A
Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.
Pharmacogenetics and genomics 2007;17(9):681-5.
2007: Masson Patrick; Froment Marie-Thérèse; Darvesh Sultan; Schopfer Lawrence M; Lockridge Oksana
Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):463-9.
2007: Rice Stephen G; Nowak Lee; Duysen Ellen G; Lockridge Oksana; Lahiri Debomoy K; Reyes Patricio F
Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2007;11(4):481-9.
2007: Li Yifeng; Li Xia; Li He; Lockridge Oksana; Wang Guangshun
A novel method for purifying recombinant human host defense cathelicidin LL-37 by utilizing its inherent property of aggregation.
Protein expression and purification 2007;54(1):157-65.
2007: Manoharan I; Kuznetsova A; Fisk J D; Boopathy R; Lockridge O; Darvesh S
Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(7):939-45.
2007: Duysen Ellen G; Li Bin; Darvesh Sultan; Lockridge Oksana
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Toxicology 2007;233(1-3):60-9.
2007: Hartmann Joachim; Kiewert Cornelia; Duysen Ellen G; Lockridge Oksana; Greig Nigel H; Klein Jochen
Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity.
Journal of neurochemistry 2007;100(5):1421-9.
2007: Manoharan Indumathi; Boopathy Rathnam; Darvesh Sultan; Lockridge Oksana
A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India.
Clinica chimica acta; international journal of clinical chemistry 2007;378(1-2):128-35.
2007: Li Bin; Schopfer Lawrence M; Hinrichs Steven H; Masson Patrick; Lockridge Oksana
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.
Analytical biochemistry 2007;361(2):263-72.
2007: Masson Patrick; Froment Marie-Thérèse; Gillon Emilie; Nachon Florian; Lockridge Oksana; Schopfer Lawrence M
Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase.
Biochimica et biophysica acta 2007;1774(1):16-34.
2006: Poyot Thomas; Nachon Florian; Froment Marie-Thérèse; Loiodice Mélanie; Wieseler Stacy; Schopfer Lawrence M; Lockridge Oksana; Masson Patrick
Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters.
Biochimica et biophysica acta 2006;1764(9):1470-8.
2006: Manoharan Indumathi; Wieseler Stacy; Layer Paul G; Lockridge Oksana; Boopathy Rathnam
Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India.
Pharmacogenetics and genomics 2006;16(7):461-8.
2006: Li Bin; Duysen Ellen G; Poluektova Larisa Y; Murrin L Charles; Lockridge Oksana
Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase.
Toxicology and applied pharmacology 2006;214(2):152-65.
2006: De Jaco Antonella; Comoletti Davide; Kovarik Zrinka; Gaietta Guido; Radic Zoran; Lockridge Oksana; Ellisman Mark H; Taylor Palmer
A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family.
The Journal of biological chemistry 2006;281(14):9667-76.
2006: Li Bin; Duysen Ellen G; Saunders Thomas L; Lockridge Oksana
Production of the butyrylcholinesterase knockout mouse.
Journal of molecular neuroscience : MN 2006;30(1-2):193-5.
2006: Wieseler Stacy; Schopfer Lawrence; Lockridge Oksana
Markers of organophosphate exposure in human serum.
Journal of molecular neuroscience : MN 2006;30(1-2):93-4.
2006: Duysen Ellen G; Lockridge Oksana
Phenotype comparison of three acetylcholinesterase knockout strains.
Journal of molecular neuroscience : MN 2006;30(1-2):91-2.
2006: Li Bin; Duysen Ellen G; Lockridge Oksana
Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP.
Journal of molecular neuroscience : MN 2006;30(1-2):79-80.
2005: Nachon F; Asojo O A; Borgstahl G; Masson P; Lockridge O
Structural data on the aging of diethylphosphoryl-butyrylcholinesterase.
Chemico-biological interactions 2005;157-158():408-9.
2005: Li He; Schopfer Lawrence; Spaulding Reggie; Thompson Charles M; Lockridge Oksana
Identification of organophosphate-reactive proteins by tandem mass spectrometry.
Chemico-biological interactions 2005;157-158():383-4.
2005: Masson Patrick; Schopfer Lawrence M; Froment Marie-Thérèse; Debouzy Jean-Claude; Nachon Florian; Gillon Emilie; Lockridge Oksana; Hrabovska Anna; Goldstein Boris N
Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics.
Chemico-biological interactions 2005;157-158():143-52.
2005: Hrabovska Anna; Duysen Ellen G; Sanders Jeffrey D; Murrin L Charles; Lockridge Oksana
Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.
Chemico-biological interactions 2005;157-158():71-8.
2005: Li Bin; Sedlacek Meghan; Manoharan Indumathi; Boopathy Rathnam; Duysen Ellen G; Masson Patrick; Lockridge Oksana
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma.
Biochemical pharmacology 2005;70(11):1673-84.
2005: Schopfer Lawrence M; Champion Matthew M; Tamblyn Nate; Thompson Charles M; Lockridge Oksana
Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410).
Analytical biochemistry 2005;345(1):122-32.
2005: Sáez-Valero Javier; de Gracia José A Pérez; Lockridge Oksana
Intraperitoneal administration of 340 kDa human plasma butyrylcholinesterase increases the level of the enzyme in the cerebrospinal fluid of rats.
Neuroscience letters 2005;383(1-2):93-8.
2005: Schopfer Lawrence M; Voelker Troy; Bartels Cynthia F; Thompson Charles M; Lockridge Oksana
Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase.
Chemical research in toxicology 2005;18(4):747-54.
2005: Nachon Florian; Asojo Oluwatoyin A; Borgstahl Gloria E O; Masson Patrick; Lockridge Oksana
Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.
Biochemistry 2005;44(4):1154-62.
2005: Peeples Eric S; Schopfer Lawrence M; Duysen Ellen G; Spaulding Reggie; Voelker Troy; Thompson Charles M; Lockridge Oksana
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(2):303-12.
2004: Bytyqi Afrim H; Lockridge Oksana; Duysen Ellen; Wang Yuxia; Wolfrum Uwe; Layer Paul G
Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors.
The European journal of neuroscience 2004;20(11):2953-62.
2004: Adler Michael; Manley Heather A; Purcell Angela L; Deshpande Sharad S; Hamilton Tracey A; Kan Robert K; Oyler George; Lockridge Oksana; Duysen Ellen G; Sheridan Robert E
Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice.
Muscle & nerve 2004;30(3):317-27.
2004: Wang Yuxia; Schopfer Lawrence M; Duysen Ellen G; Nachon Florian; Masson Patrick; Lockridge Oksana
Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants.
Analytical biochemistry 2004;329(1):131-8.
2004: Masson Patrick; Bec Nicole; Froment Marie-Thérèse; Nachon Florian; Balny Claude; Lockridge Oksana; Schopfer Lawrence M
Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior.
European journal of biochemistry / FEBS 2004;271(10):1980-90.
2004: Wang Yuxia; Boeck Andreea Ticu; Duysen Ellen G; Van Keuren Margaret; Saunders Thomas L; Lockridge Oksana
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.
Toxicology and applied pharmacology 2004;196(3):356-66.
2004: Masson Patrick; Goldstein Boris N; Debouzy Jean-Claude; Froment Marie-Thérèse; Lockridge Oksana; Schopfer Lawrence M
Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate.
European journal of biochemistry / FEBS 2004;271(1):220-34.
2003: Volpicelli-Daley Laura A; Hrabovska Anna; Duysen Ellen G; Ferguson Shawn M; Blakely Randy D; Lockridge Oksana; Levey Allan I
Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.
Molecular pharmacology 2003;64(6):1309-16.
2003: Saxena Ashima; Fedorko James M; Vinayaka C R; Medhekar Rohit; Radic Zoran; Taylor Palmer; Lockridge Oksana; Doctor Bhupendra P
Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.
European journal of biochemistry / FEBS 2003;270(22):4447-58.
2003: Nicolet Yvain; Lockridge Oksana; Masson Patrick; Fontecilla-Camps Juan C; Nachon Florian
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
The Journal of biological chemistry 2003;278(42):41141-7.
2003: Volpicelli-Daley Laura A; Duysen Ellen G; Lockridge Oksana; Levey Allan I
Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice.
Annals of neurology 2003;53(6):788-96.
2003: Bernard Véronique; Brana Corinne; Liste Isabel; Lockridge Oksana; Bloch Bertrand
Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice.
Molecular and cellular neurosciences 2003;23(1):121-33.
2003: Li Bin; Duysen Ellen G; Volpicelli-Daley Laura A; Levey Allan I; Lockridge Oksana
Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.
Pharmacology, biochemistry, and behavior 2003;74(4):977-86.
2003: Masson Patrick; Nachon Florian; Bartels Cynthia F; Froment Marie-Therese; Ribes Fabien; Matthews Cedric; Lockridge Oksana
High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine.
European journal of biochemistry / FEBS 2003;270(2):315-24.
2002: Haux J Eric; Lockridge Oksana; Casida John E
Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent.
Chemical research in toxicology 2002;15(12):1527-33.
2002: Duysen Ellen Gail; Fry Debra Lucie; Lockridge Oksana
Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony.
Comparative medicine 2002;52(5):461-6.
2002: Duysen Ellen G; Bartels Cynthia F; Lockridge Oksana
Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity.
The Journal of pharmacology and experimental therapeutics 2002;302(2):751-8.
2002: Sun Hong; Shen Maryann L; Pang Yuan-Ping; Lockridge Oksana; Brimijoin Stephen
Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.
The Journal of pharmacology and experimental therapeutics 2002;302(2):710-6.
2002: Sun Hong; Pang Yuan-Ping; Lockridge Oksana; Brimijoin Stephen
Re-engineering butyrylcholinesterase as a cocaine hydrolase.
Molecular pharmacology 2002;62(2):220-4.
2002: Duysen Ellen G; Stribley Judith A; Fry Debra L; Hinrichs Steven H; Lockridge Oksana
Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.
Brain research. Developmental brain research 2002;137(1):43-54.
2002: Boeck Andreea Ticu; Schopfer Lawrence M; Lockridge Oksana
DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase.
Biochemical pharmacology 2002;63(12):2101-10.
2002: Boeck Andreea Ticu; Fry Debra L; Sastre Antonio; Lockridge Oksana
Naturally occurring mutation, Asp70his, in human butyrylcholinesterase.
Annals of clinical biochemistry 2002;39(Pt 2):154-6.
2002: Masson Patrick; Schopfer Lawrence M; Bartels Cynthia F; Froment Marie-Thérèse; Ribes Fabien; Nachon Florian; Lockridge Oksana
Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite.
Biochimica et biophysica acta 2002;1594(2):313-24.
2002: Nachon Florian; Nicolet Yvain; Viguié Nathalie; Masson Patrick; Fontecilla-Camps Juan C; Lockridge Oksana
Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization.
European journal of biochemistry / FEBS 2002;269(2):630-7.
2002: Mesulam M-M; Guillozet A; Shaw P; Levey A; Duysen E G; Lockridge O
Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine.
Neuroscience 2002;110(4):627-39.
2001: Josse D; Lockridge O; Xie W; Bartels C F; Schopfer L M; Masson P
The active site of human paraoxonase (PON1).
Journal of applied toxicology : JAT 2001;21 Suppl 1():S7-11.
2001: Duysen E G; Li B; Xie W; Schopfer L M; Anderson R S; Broomfield C A; Lockridge O
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.
The Journal of pharmacology and experimental therapeutics 2001;299(2):528-35.
2001: Sun H; El Yazal J; Lockridge O; Schopfer L M; Brimijoin S; Pang Y P
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
The Journal of biological chemistry 2001;276(12):9330-6.
2001: Masson P; Xie W; Froment M T; Lockridge O
Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase.
Biochimica et biophysica acta 2001;1544(1-2):166-76.
2000: Li B; Stribley J A; Ticu A; Xie W; Schopfer L M; Hammond P; Brimijoin S; Hinrichs S H; Lockridge O
Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse.
Journal of neurochemistry 2000;75(3):1320-31.
2000: Bartels C F; Xie W; Miller-Lindholm A K; Schopfer L M; Lockridge O
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.
Biochemical pharmacology 2000;60(4):479-87.
2000: Xie W; Stribley J A; Chatonnet A; Wilder P J; Rizzino A; McComb R D; Taylor P; Hinrichs S H; Lockridge O
Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase.
The Journal of pharmacology and experimental therapeutics 2000;293(3):896-902.
2000: Lockridge O; Masson P
Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk.
Neurotoxicology 2000;21(1-2):113-26.
2000: Altamirano C V; Bartels C F; Lockridge O
The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme.
Journal of neurochemistry 2000;74(2):869-77.
1999: Altamirano C V; Lockridge O
Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers.
Biochemistry 1999;38(40):13414-22.
1999: Masson P; Xie W; Froment M T; Levitsky V; Fortier P L; Albaret C; Lockridge O
Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates.
Biochimica et biophysica acta 1999;1433(1-2):281-93.
1999: Broomfield C A; Lockridge O; Millard C B
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.
Chemico-biological interactions 1999;119-120():413-8.
1999: Xie W; Wilder P J; Stribley J; Chatonnet A; Rizzino A; Taylor P; Hinrichs S H; Lockridge O
Knockout of one acetylcholinesterase allele in the mouse.
Chemico-biological interactions 1999;119-120():289-99.
1999: Josse D; Xie W; Masson P; Schopfer L M; Lockridge O
Tryptophan residue(s) as major components of the human serum paraoxonase active site.
Chemico-biological interactions 1999;119-120():79-84.
1999: Josse D; Xie W; Masson P; Lockridge O
Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis.
Chemico-biological interactions 1999;119-120():71-8.
1999: Saxena A; Redman A M; Jiang X; Lockridge O; Doctor B P
Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
Chemico-biological interactions 1999;119-120():61-9.
1999: Altamirano C V; Lockridge O
Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus.
Chemico-biological interactions 1999;119-120():53-60.
1999: Masson P; Fortier P L; Albaret C; Cléry C; Guerra P; Lockridge O
Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process.
Chemico-biological interactions 1999;119-120():17-27.
1999: Josse D; Xie W; Renault F; Rochu D; Schopfer L M; Masson P; Lockridge O
Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities.
Biochemistry 1999;38(9):2816-25.
1999: Levitsky V; Xie W; Froment M T; Lockridge O; Masson P
Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant.
Biochimica et biophysica acta 1999;1429(2):422-30.
1999: Xie W; Altamirano C V; Bartels C F; Speirs R J; Cashman J R; Lockridge O
An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.
Molecular pharmacology 1999;55(1):83-91.
1998: Vanlinthout L E; Bartels C F; Lockridge O; Callens K; Booij L H
Prolonged paralysis after a test dose of mivacurium in a patient with atypical serum cholinesterase.
Anesthesia and analgesia 1998;87(5):1199-202.
1998: Saxena A; Viragh C; Frazier D S; Kovach I M; Maxwell D M; Lockridge O; Doctor B P
The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.
Biochemistry 1998;37(43):15086-96.
1998: Masson P; Josse D; Lockridge O; Viguié N; Taupin C; Buhler C
Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning.
Journal of physiology, Paris 1998;92(5-6):357-62.
1998: Froment M T; Lockridge O; Masson P
Resistance of butyrylcholinesterase to inactivation by ultrasound: effects of ultrasound on catalytic activity and subunit association.
Biochimica et biophysica acta 1998;1387(1-2):53-64.
1998: Masson P; Froment M T; Fortier P L; Visicchio J E; Bartels C F; Lockridge O
Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters.
Biochimica et biophysica acta 1998;1387(1-2):41-52.
1998: Millard C B; Lockridge O; Broomfield C A
Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase.
Biochemistry 1998;37(1):237-47.
1997: Saxena A; Redman A M; Jiang X; Lockridge O; Doctor B P
Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
Biochemistry 1997;36(48):14642-51.
1997: Blong R M; Bedows E; Lockridge O
Tetramerization domain of human butyrylcholinesterase is at the C-terminus.
The Biochemical journal 1997;327 ( Pt 3)():747-57.
1997: Masson P; Fortier P L; Albaret C; Froment M T; Bartels C F; Lockridge O
Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.
The Biochemical journal 1997;327 ( Pt 2)():601-7.
1997: Masson P; Froment M T; Bartels C F; Lockridge O
Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase.
The Biochemical journal 1997;325 ( Pt 1)():53-61.
1997: Masson P; Legrand P; Bartels C F; Froment M T; Schopfer L M; Lockridge O
Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.
Biochemistry 1997;36(8):2266-77.
1997: Lockridge O; Blong R M; Masson P; Froment M T; Millard C B; Broomfield C A
A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.
Biochemistry 1997;36(4):786-95.
1996: Masson P; Froment M T; Bartels C F; Lockridge O
Asp7O in the peripheral anionic site of human butyrylcholinesterase.
European journal of biochemistry / FEBS 1996;235(1-2):36-48.
1995: Millard C B; Lockridge O; Broomfield C A
Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase.
Biochemistry 1995;34(49):15925-33.
1995: Sorenson R C; Primo-Parmo S L; Kuo C L; Adkins S; Lockridge O; La Du B N
Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7187-91.
1994: Jbilo O; Bartels C F; Chatonnet A; Toutant J P; Lockridge O
Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA.
Toxicon : official journal of the International Society on Toxinology 1994;32(11):1445-57.
1994: Kris M; Jbilo O; Bartels C F; Masson P; Rhode S; Lockridge O
Endogenous butyrylcholinesterase in SV40 transformed cell lines: COS-1, COS-7, MRC-5 SV40, and WI-38 VA13.
In vitro cellular & developmental biology. Animal 1994;30A(10):680-9.
1994: Huth J R; Norton S E; Lockridge O; Shikone T; Hsueh A J; Ruddon R W
Bacterial expression and in vitro folding of the beta-subunit of human chorionic gonadotropin (hCG beta) and functional assembly of recombinant hCG beta with hCG alpha.
Endocrinology 1994;135(3):911-8.
1994: Jbilo O; Toutant J P; Vatsis K P; Chatonnet A; Lockridge O
Promoter and transcription start site of human and rabbit butyrylcholinesterase genes.
The Journal of biological chemistry 1994;269(33):20829-37.
1994: Masson P; Froment M T; Sorenson R C; Bartels C F; Lockridge O
Mutation His322Asn in human acetylcholinesterase does not alter electrophoretic and catalytic properties of the erythrocyte enzyme.
Blood 1994;83(10):3003-5.
1993: Huth J R; Perini F; Lockridge O; Bedows E; Ruddon R W
Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase.
The Journal of biological chemistry 1993;268(22):16472-82.
1993: Masson P; Adkins S; Gouet P; Lockridge O
Recombinant human butyrylcholinesterase G390V, the fluoride-2 variant, expressed in Chinese hamster ovary cells, is a low affinity variant.
The Journal of biological chemistry 1993;268(19):14329-41.
1993: Bartels C F; Zelinski T; Lockridge O
Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism.
American journal of human genetics 1993;52(5):928-36.
1992: Nogueira C P; Bartels C F; McGuire M C; Adkins S; Lubrano T; Rubinstein H M; Lightstone H; Van der Spek A F; Lockridge O; La Du B N
Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase.
American journal of human genetics 1992;51(4):821-8.
1992: Bartels C F; Jensen F S; Lockridge O; van der Spek A F; Rubinstein H M; Lubrano T; La Du B N
DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites.
American journal of human genetics 1992;50(5):1086-103.
1991: Saito K; Thiele D J; Davio M; Lockridge O; Massey V
The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis.
The Journal of biological chemistry 1991;266(31):20720-4.
1991: Arpagaus M; Chatonnet A; Masson P; Newton M; Vaughan T A; Bartels C F; Nogueira C P; La Du B N; Lockridge O
Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates.
The Journal of biological chemistry 1991;266(11):6966-74.
1991: La Du B N; Bartels C F; Nogueira C P; Arpagaus M; Lockridge O
Proposed nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing.
Cellular and molecular neurobiology 1991;11(1):79-89.
1990: La Du B N; Bartels C F; Nogueira C P; Hajra A; Lightstone H; Van der Spek A; Lockridge O
Phenotypic and molecular biological analysis of human butyrylcholinesterase variants.
Clinical biochemistry 1990;23(5):423-31.
1990: Nogueira C P; McGuire M C; Graeser C; Bartels C F; Arpagaus M; Van der Spek A F; Lightstone H; Lockridge O; La Du B N
Identification of a frameshift mutation responsible for the silent phenotype of human serum cholinesterase, Gly 117 (GGT----GGAG).
American journal of human genetics 1990;46(5):934-42.
1990: Masson P; Chatonnet A; Lockridge O
Evidence for a single butyrylcholinesterase gene in individuals carrying the C5 plasma cholinesterase variant (CHE2).
FEBS letters 1990;262(1):115-8.
1990: Arpagaus M; Kott M; Vatsis K P; Bartels C F; La Du B N; Lockridge O
Structure of the gene for human butyrylcholinesterase. Evidence for a single copy.
Biochemistry 1990;29(1):124-31.
1990: Lockridge O
Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.
Pharmacology & therapeutics 1990;47(1):35-60.
1989: Chatonnet A; Lockridge O
Comparison of butyrylcholinesterase and acetylcholinesterase.
The Biochemical journal 1989;260(3):625-34.
1989: McGuire M C; Nogueira C P; Bartels C F; Lightstone H; Hajra A; Van der Spek A F; Lockridge O; La Du B N
Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):953-7.
1987: McTiernan C; Adkins S; Chatonnet A; Vaughan T A; Bartels C F; Kott M; Rosenberry T L; La Du B N; Lockridge O
Brain cDNA clone for human cholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6682-6.
1987: Lockridge O; Adkins S; La Du B N
Location of disulfide bonds within the sequence of human serum cholinesterase.
The Journal of biological chemistry 1987;262(27):12945-52.
1987: Lockridge O; Bartels C F; Vaughan T A; Wong C K; Norton S E; Johnson L L
Complete amino acid sequence of human serum cholinesterase.
The Journal of biological chemistry 1987;262(2):549-57.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Oksana Lockridge

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Physiology

Genes & Molecular Sequences

Phenomena

Anatomy

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Oksana Lockridge (preview)

All Publications