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Richard Locksley

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Jose E Heredia; Richard M Locksley; Alisa A Mueller; Lata Mukundan; Thomas A Rando; Francis M Chen; Rahul C Deo; Ajay Chawla
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Richard M Locksley
Raggin' on T-bet.
Ari B Molofsky; Jesse C Nussbaum; Steven J Van Dyken; Alexander Mohapatra; Ajay Chawla; Laurence E Cheng; Hong-Erh Liang; Richard M Locksley
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.

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2013: Jose E Heredia; Richard M Locksley; Alisa A Mueller; Lata Mukundan; Thomas A Rando; Francis M Chen; Rahul C Deo; Ajay Chawla
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Cell 2013;153(2):376-88.
2013: Richard M Locksley
Raggin' on T-bet.
Cell metabolism 2013;17(4):473-4.
2013: Ari B Molofsky; Jesse C Nussbaum; Steven J Van Dyken; Alexander Mohapatra; Ajay Chawla; Laurence E Cheng; Hong-Erh Liang; Richard M Locksley
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
The Journal of experimental medicine 2013;210(3):535-49.
2013: Hergen Spits; David Artis; Marco Colonna; James P Di Santo; Andreas Diefenbach; Gerard Eberl; Shigeo Koyasu; Richard M Locksley; Andrew N J McKenzie; Reina E Mebius; Fiona Powrie; Eric Vivier
Innate lymphoid cells--a proposal for uniform nomenclature.
Nature reviews. Immunology 2013;13(2):145-9.
2013: Laurence E Cheng; Karin Hartmann; Matthew F Krummel; Axel Roers; Richard M Locksley
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
Immunity 2013;38(1):166-75.
2013: Steven J Van Dyken; Richard M Locksley
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.
Annual review of immunology 2013;31():317-43.
2012: Nina Dickgreber; Kathryn J Farrand; Alan G Baxter; Mei L Chong; Deborah A Knight; Graham Le Gros; Richard M Locksley; Sara J McKee; Socorro Miranda-Hernandez; Nicholas van Panhuys; Ian F Hermans
Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.
Journal of leukocyte biology 2012;92(5):999-1009.
2012: Jesse C Nussbaum; Richard M Locksley
Infectious (Non)tolerance--frustrated commensalism gone awry?
Cold Spring Harbor perspectives in biology 2012;4(5):.
2012: April E Price; R Lee Reinhardt; Hong-Erh Liang; Richard M Locksley
Marking and quantifying IL-17A-producing cells in vivo.
PloS one 2012;7(6):e39750.
2011: Khoa D Nguyen; Yifu Qiu; Frank Brombacher; Xiaojin Cui; Tovo David; Y P Sharon Goh; Richard M Locksley; Lata Mukundan; Julia Mwangi; Ajay Chawla
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.
Nature 2011;480(7375):104-8.
2011: Emily R Elliott; Richard M Locksley; Patrizia Scapini; Brandon M Sullivan; Jessica A Van Ziffle; Clifford A Lowell
Deletion of Syk in neutrophils prevents immune complex arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4319-30.
2011: Steven J Van Dyken; Paul C Porter; Patricia J Quinlan; Paul D Blanc; David B Corry; Daniel Garcia; Xiaozhu Huang; Richard M Locksley
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2261-7.
2011: John V Fahy; Richard M Locksley
The airway epithelium as a regulator of Th2 responses in asthma.
American journal of respiratory and critical care medicine 2011;184(4):390-2.
2011: Brandon M Sullivan; Hong-Erh Liang; Jennifer K Bando; Davina Wu; Laurence E Cheng; James K McKerrow; Christopher D C Allen; Richard M Locksley
Genetic analysis of basophil function in vivo.
Nature immunology 2011;12(6):527-35.
2011: Davina Wu; Ari B Molofsky; Hong-Erh Liang; Roberto R Ricardo-Gonzalez; Hani A Jouihan; Jennifer K Bando; Ajay Chawla; Richard M Locksley
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
Science (New York, N.Y.) 2011;332(6026):243-7.
2010: Roberto R Ricardo-Gonzalez; Alex Red Eagle; Justin I Odegaard; Hani Jouihan; Christine R Morel; Jose E Heredia; Lata Mukundan; Davina Wu; Richard M Locksley; Ajay Chawla
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22617-22.
2010: Zhiyong Yang; Zhi-En Wang; Paschalis-Thomas Doulias; Wei Wei; Harry Ischiropoulos; Richard M Locksley; Limin Liu
Lymphocyte development requires S-nitrosoglutathione reductase.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6664-9.
2010: Laurence E Cheng; Zhi-En Wang; Richard M Locksley
Murine B cells regulate serum IgE levels in a CD23-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5040-7.
2010: April E Price; Hong-Erh Liang; Brandon M Sullivan; R Lee Reinhardt; Chris J Eisley; David J Erle; Richard M Locksley
Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11489-94.
2010: Richard M Locksley
Asthma and allergic inflammation.
Cell 2010;140(6):777-83.
2009: Roman Barbalat; Laura Lau; Richard M Locksley; Gregory M Barton
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands.
Nature immunology 2009;10(11):1200-7.
2009: Kelly M Kroeger; Brandon M Sullivan; Richard M Locksley
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway.
Journal of leukocyte biology 2009;86(4):769-78.
2009: Michael Mingueneau; Romain Roncagalli; Claude Grégoire; adrien kissenpfennig; Arkadiusz Miazek; Cristel Archambaud; Ying Wang; Pierre Perrin; Elodie Bertosio; Amandine Sansoni; Sylvie Richelme; Richard M Locksley; Enrique Aguado; Marie Malissen; Bernard Malissen
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Immunity 2009;31(2):197-208.
2009: Richard M Locksley
Nine lives: plasticity among T helper cell subsets.
The Journal of experimental medicine 2009;206(8):1643-6.
2009: Max A Seibold; Tiffany A Reese; Shweta Choudhry; Muhammad T Salam; Kenny Beckman; Celeste Eng; Amha Atakilit; Kelley Meade; Michael Lenoir; H Geoffrey Watson; Shannon Thyne; Rajesh Kumar; Kevin B Weiss; Leslie C Grammer; Pedro Avila; Robert P Schleimer; John V Fahy; Jose Rodriguez-Santana; William Rodriguez-Cintron; Rolf G Boot; Dean Sheppard; Frank D Gilliland; Richard M Locksley; Esteban G Burchard
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
The Journal of biological chemistry 2009;284(29):19650-8.
2009: Antonio Gigliotti Rothfuchs; Jackson G Egen; Carl G Feng; Lis R V Antonelli; sulay moreno; Nathalie Winter; Richard M Locksley; Alan Sher
In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6915-25.
2009: R Lee Reinhardt; Hong-Erh Liang; Richard M Locksley
Cytokine-secreting follicular T cells shape the antibody repertoire.
Nature immunology 2009;10(4):385-93.
2009: Brandon M Sullivan; Richard M Locksley
Basophils: a nonredundant contributor to host immunity.
Immunity 2009;30(1):12-20.
2009: Suk-Jo Kang; Richard M Locksley
The inflammasome and alum-mediated adjuvanticity.
F1000 biology reports 2009;1():15.
2009: David Voehringer; Davina Wu; Hong-Erh Liang; Richard M Locksley
Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates.
BMC biotechnology 2009;9():69.
2008: Suk-Jo Kang; Hong-Erh Liang; Boris Reizis; Richard M Locksley
Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
Immunity 2008;29(5):819-33.
2008: Richard T Robinson; Shabaana A Khader; Richard M Locksley; Egil Lien; Stephen T Smiley; Andrea M Cooper
Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5560-7.
2008: Alusha A Mamchak; Brandon M Sullivan; Baidong Hou; Linda M Lee; Julia Gilden; Matthew F Krummel; Richard M Locksley; Anthony L DeFranco
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5374-85.
2008: Kirk D C Jensen; Xiaoqin Su; Sunny Shin; Luke Li; Sawsan Youssef; Sho Yamasaki; Lawrence Steinman; Takashi Saito; Richard M Locksley; Mark M Davis; Nicole Baumgarth; Yueh-hsiu Chien
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
Immunity 2008;29(1):90-100.
2008: Richard M Locksley
The Roaring Twenties.
Immunity 2008;28(4):437-9.
2008: David Voehringer; Hong-Erh Liang; Richard M Locksley
Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4742-53.
2007: Steven J Van Dyken; Richard M Locksley
Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity.
Immunology and cell biology 2007;85(8):572-4.
2007: Pascal Launois; Sabine Pingel; Hayo Himmelrich; Richard M Locksley; Jacques Louis
Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major.
Microbes and infection / Institut Pasteur 2007;9(11):1260-6.
2007: Scott N Mueller; Karoline A Hosiawa-Meagher; Bogumila T Konieczny; Brandon M Sullivan; Martin F Bachmann; Richard M Locksley; Rafi Ahmed; Mehrdad Matloubian
Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
Science (New York, N.Y.) 2007;317(5838):670-4.
2007: David Voehringer; Sarah A Stanley; Jeffery S Cox; Gladys Completo; Todd L Lowary; Richard M Locksley
Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.
Experimental parasitology 2007;116(4):458-66.
2007: Roza I Nurieva; Sergei Chuvpilo; Eric Wieder; Keith B Elkon; Richard M Locksley; Edgar Serfling; Chen Dong
A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1096-103.
2007: David Voehringer; N van Rooijen; Richard M Locksley
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages.
Journal of leukocyte biology 2007;81(6):1434-44.
2007: Tiffany A Reese; Hong-Erh Liang; Andrew M Tager; Andrew D Luster; Nico van Rooijen; David Voehringer; Richard M Locksley
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
Nature 2007;447(7140):92-6.
2007: Shabaana A Khader; Guy K Bell; John E Pearl; Jeffrey J Fountain; Javier Rangel Moreno; Garth E Cilley; Fang Shen; SHERI M EATON; Sarah L Gaffen; Susan L Swain; Richard M Locksley; Laura Haynes; Troy D Randall; Andrea M Cooper
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
Nature immunology 2007;8(4):369-77.
2006: Xiang Xu; Dongji Zhang; Hong Zhang; Paul wolters; Nigel Killeen; Brandon M Sullivan; Richard M Locksley; Clifford A Lowell; George H Caughey
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
The Journal of experimental medicine 2006;203(13):2907-17.
2006: Richard M Locksley
A failure to launch: fuelling cytokine secretion in iNKT cells.
Immunity 2006;25(3):393-5.
2006: Brian T Fife; Matthew D Griffin; Abul K Abbas; Richard M Locksley; Jeffrey A Bluestone
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
The Journal of clinical investigation 2006;116(8):2252-61.
2006: R Lee Reinhardt; Seokmann Hong; Suk-Jo Kang; Zhi-En Wang; Richard M Locksley
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1618-27.
2006: David Voehringer; Tiffany A Reese; Xiaozhu Huang; Kanade Shinkai; Richard M Locksley
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.
The Journal of experimental medicine 2006;203(6):1435-46.
2006: Stefanie Scheu; Daniel B Stetson; R Lee Reinhardt; Jess H Leber; Markus Mohrs; Richard M Locksley
Activation of the integrated stress response during T helper cell differentiation.
Nature immunology 2006;7(6):644-51.
2006: Alain Gumy; Abraham Aseffa; Nicolas Rachinel; Melanie Breton; Luc A Otten; Fabienne Tacchini-Cottier; Martin Röcken; Noelle Doyen; Hans Acha-Orbea; Richard M Locksley; H Robson MacDonald; Pascal Launois; Jacques Louis
LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.
European journal of immunology 2006;36(6):1465-73.
2006: R Lee Reinhardt; Suk-Jo Kang; Hong-Erh Liang; Richard M Locksley
T helper cell effector fates--who, how and where?
Current opinion in immunology 2006;18(3):271-7.
2006: Toshiro Hayashida; Masako Oda; Kanako Ohsawa; Atsumi Yamaguchi; Takumi Hosozawa; Richard M Locksley; Mauro Giacca; Hisao Masai; Shoichiro Miyatake
Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5446-54.
2006: Marc Veldhoen; Richard J Hocking; Christopher J Atkins; Richard M Locksley; Brigitta Stockinger
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Immunity 2006;24(2):179-89.
2006: Qizhi Tang; Jason Y Adams; Aaron J Tooley; Mingying Bi; Brian T Fife; Pau Serra; Pere Santamaria; Richard M Locksley; Matthew F Krummel; Jeffrey A Bluestone
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Nature immunology 2006;7(1):83-92.
2005: Wooseok Im; Hyojeong Kim; Daesun Yun; Sung-Yum Seo; Se-Ho Park; Richard M Locksley; Seokmann Hong
Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds.
Molecules and cells 2005;20(2):288-96.
2005: Katja Mohrs; Adil E Wakil; Nigel Killeen; Richard M Locksley; Markus Mohrs
A two-step process for cytokine production revealed by IL-4 dual-reporter mice.
Immunity 2005;23(4):419-29.
2005: P'ng Loke; Xingxing Zang; Lisa Hsuan; Rebecca Waitz; Richard M Locksley; Judith E Allen; James P Allison
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9872-7.
2005: Koichiro Ohmura; Linh T Nguyen; Richard M Locksley; Diane Mathis; Christophe Benoist
Interleukin-4 can be a key positive regulator of inflammatory arthritis.
Arthritis and rheumatism 2005;52(6):1866-75.
2004: David Voehringer; David Brian Rosen; Lewis L Lanier; Richard M Locksley
CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
The Journal of biological chemistry 2004;279(52):54117-23.
2004: Ben L Kelly; Richard M Locksley
The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice.
Infection and immunity 2004;72(12):6924-31.
2004: Min Xu; Zhien Wang; Richard M Locksley
Innate immune responses in peptidoglycan recognition protein L-deficient mice.
Molecular and cellular biology 2004;24(18):7949-57.
2004: David Voehringer; Kanade Shinkai; Richard M Locksley
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production.
Immunity 2004;20(3):267-77.
2004: Daniel B Stetson; David Voehringer; Jane Grogan; Min Xu; R Lee Reinhardt; Stefanie Scheu; Ben L Kelly; Richard M Locksley
Th2 cells: orchestrating barrier immunity.
Advances in immunology 2004;83():163-89.
2003: Jane Grogan; Zhi-En Wang; Sarah Stanley; Brian Harmon; Gabriela G Loots; Edward M Rubin; Richard M Locksley
Basal chromatin modification at the IL-4 gene in helper T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6672-9.
2003: Ben L Kelly; Daniel B Stetson; Richard M Locksley
Leishmania major LACK antigen is required for efficient vertebrate parasitization.
The Journal of experimental medicine 2003;198(11):1689-98.
2003: Daniel B Stetson; Markus Mohrs; R Lee Reinhardt; Jody L Baron; Zhi-En Wang; Laurent Gapin; Mitchell Kronenberg; Richard M Locksley
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
The Journal of experimental medicine 2003;198(7):1069-76.
2003: Jennifer L Matsuda; Laurent Gapin; Jody L Baron; Stéphane Sidobre; Daniel B Stetson; Markus Mohrs; Richard M Locksley; Mitchell Kronenberg
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8395-400.
2003: Husein Hadeiba; Richard M Locksley
Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5502-10.
2003: Markus Mohrs; Dee A Lacy; Richard M Locksley
Stat signals release activated naive Th cells from an anergic checkpoint.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1870-6.
2003: Helene Bour-Jordan; Jane Grogan; Qizhi Tang; Julie A Auger; Richard M Locksley; Jeffrey A Bluestone
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Nature immunology 2003;4(2):182-8.
2002: Kanade Shinkai; Markus Mohrs; Richard M Locksley
Helper T cells regulate type-2 innate immunity in vivo.
Nature 2002;420(6917):825-9.
2002: Daniel B Stetson; Markus Mohrs; Valérie Mallet-Designe; Luc Teyton; Richard M Locksley
Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.
Immunity 2002;17(2):191-200.
2002: Richard M Locksley
Blood lines.
Nature immunology 2002;3(8):705-6.
2002: Jane Grogan; Richard M Locksley
T helper cell differentiation: on again, off again.
Current opinion in immunology 2002;14(3):366-72.
2002: Pascal Launois; Alain Gumy; Hayo Himmelrich; Richard M Locksley; Martin Röcken; Jacques A Louis
Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4628-35.
2002: Jody L Baron; Leon Gardiner; Stephen Nishimura; Kanade Shinkai; Richard M Locksley; Don Ganem
Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection.
Immunity 2002;16(4):583-94.
2001: Stephen J Davies; Jane Grogan; Rebecca B Blank; Kee-Chong Lim; Richard M Locksley; James H McKerrow
Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.
Science (New York, N.Y.) 2001;294(5545):1358-61.
2001: Markus Mohrs; C M Blankespoor; Zhi-En Wang; Gabriela G Loots; V Afzal; Husein Hadeiba; Kanade Shinkai; Edward M Rubin; Richard M Locksley
Deletion of a coordinate regulator of type 2 cytokine expression in mice.
Nature immunology 2001;2(9):842-7.
2001: Markus Mohrs; Kanade Shinkai; Katja Mohrs; Richard M Locksley
Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter.
Immunity 2001;15(2):303-11.
2001: Ivan P Maillard; Pascal Launois; Hayo Himmelrich; Hans Acha-Orbea; Heidi Diggelmann; Richard M Locksley; Jacques A Louis
Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.
European journal of immunology 2001;31(4):1288-96.
2001: Jane Grogan; Markus Mohrs; Brian Harmon; Dee A Lacy; John W Sedat; Richard M Locksley
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
Immunity 2001;14(3):205-15.
2001: Richard M Locksley; Nigel Killeen; M J Lenardo
The TNF and TNF receptor superfamilies: integrating mammalian biology.
Cell 2001;104(4):487-501.
2000: Ben L Kelly; Richard M Locksley
Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):2982-6.
2000: S Gurunathan; L Stobie; Calman Prussin; David L Sacks; Nicolas Glaichenhaus; A Iwasaki; DJ Fowell; Richard M Locksley; J T Chang; Chang-You Wu; Robert A Seder
Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):915-24.
2000: Husein Hadeiba; David B Corry; Richard M Locksley
Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4933-40.
2000: Hayo Himmelrich; Pascal Launois; Ivan P Maillard; Tilo Biedermann; Fabienne Tacchini-Cottier; Richard M Locksley; Martin Röcken; Jacques A Louis
In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4819-25.
2000: Dee A Lacy; Zhi-En Wang; D J Symula; C J McArthur; Edward M Rubin; Kelly A Frazer; Richard M Locksley
Faithful expression of the human 5q31 cytokine cluster in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4569-74.
2000: Gabriela G Loots; Richard M Locksley; C M Blankespoor; Zhi-En Wang; Webb Miller; Edward M Rubin; Kelly A Frazer
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
Science (New York, N.Y.) 2000;288(5463):136-40.
1999: SD Pippig; Claudia Peña-Rossi; J Long; Wayne Godfrey; DJ Fowell; Steven L Reiner; M L Birkeland; Richard M Locksley; A N Barclay; Nigel Killeen
Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6520-9.
1999: DJ Fowell; Kanade Shinkai; X C Liao; Amy M Beebe; Robert L Coffman; Dan R Littman; Richard M Locksley
Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
Immunity 1999;11(4):399-409.
1999: D J Symula; Kelly A Frazer; Y Ueda; Patrice DENEFLE; M E Stevens; Zhi-En Wang; Richard M Locksley; Edward M Rubin
Functional screening of an asthma QTL in YAC transgenic mice.
Nature genetics 1999;23(2):241-4.
1999: DJ Fowell; Richard M Locksley
Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(6):510-8.
1999: Sabine Pingel; Pascal Launois; DJ Fowell; C W Turck; S Southwood; A Sette; Nicolas Glaichenhaus; Jacques A Louis; Richard M Locksley
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
The Journal of experimental medicine 1999;189(7):1111-20.
1999: Richard M Locksley; Sabine Pingel; D Lacy; Adil E Wakil; Mark Bix; DJ Fowell
Susceptibility to infectious diseases: Leishmania as a paradigm.
The Journal of infectious diseases 1999;179 Suppl 2():S305-8.
1998: Mark Bix; Zhi-En Wang; B Thiel; N J Schork; Richard M Locksley
Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.
The Journal of experimental medicine 1998;188(12):2289-99.
1998: Gabriele Grünig; Martha Warnock; Adil E Wakil; Rajeev Venkayya; Frank Brombacher; Donna Rennick; D Sheppard; Markus Mohrs; Debra D Donaldson; Richard M Locksley; David B Corry
Requirement for IL-13 independently of IL-4 in experimental asthma.
Science (New York, N.Y.) 1998;282(5397):2261-3.
1998: Adil E Wakil; Zhi-En Wang; J C Ryan; DJ Fowell; Richard M Locksley
Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.
The Journal of experimental medicine 1998;188(9):1651-6.
1998: DJ Fowell; Mark Bix; Kanade Shinkai; D Lacy; Richard M Locksley
Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.
European cytokine network 1998;9(3 Suppl):102-6.
1998: Mark Bix; Richard M Locksley
Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells.
Science (New York, N.Y.) 1998;281(5381):1352-4.
1998: David B Corry; Gabriele Grünig; Husein Hadeiba; Viswanath P Kurup; Martha Warnock; D Sheppard; Donna Rennick; Richard M Locksley
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.
Molecular medicine (Cambridge, Mass.) 1998;4(5):344-55.
1998: Sabine Pingel; Zhi-En Wang; Richard M Locksley
Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
Infection and immunity 1998;66(4):1795-9.
1998: Steven L Reiner; DJ Fowell; NH Moskowitz; Kevin Swier; DR Brown; Charles R Brown; C W Turck; P A Scott; Nigel Killeen; Richard M Locksley
Control of Leishmania major by a monoclonal alpha beta T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):884-9.
1998: Richard M Locksley; DJ Fowell; Kanade Shinkai; Adil E Wakil; D Lacy; Mark Bix
Development of CD4+ effector T cells and susceptibility to infectious diseases.
Advances in experimental medicine and biology 1998;452():45-52.
1997: Amy Hagenbaugh; Sherven Sharma; S M Dubinett; S H Wei; Richard Aranda; Hilde Cheroutre; DJ Fowell; S Binder; B Tsao; Richard M Locksley; K W Moore; Mitchell Kronenberg
Altered immune responses in interleukin 10 transgenic mice.
The Journal of experimental medicine 1997;185(12):2101-10.
1997: DJ Fowell; J Magram; C W Turck; Nigel Killeen; Richard M Locksley
Impaired Th2 subset development in the absence of CD4.
Immunity 1997;6(5):559-69.
1997: Pascal Launois; Ivan P Maillard; Sabine Pingel; K G Swihart; I Xénarios; Hans Acha-Orbea; Heidi Diggelmann; Richard M Locksley; H Robson MacDonald; Jacques A Louis
IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.
Immunity 1997;6(5):541-9.
1997: Frazier T Stevenson; Johanna Turck; Richard M Locksley; David H Lovett
The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):508-13.
1997: DR Brown; Kevin Swier; NH Moskowitz; M F Naujokas; Richard M Locksley; Steven L Reiner
T helper subset differentiation in the absence of invariant chain.
The Journal of experimental medicine 1997;185(1):31-41.
1996: Adil E Wakil; Zhi-En Wang; Richard M Locksley
Leishmania major: targeting IL-4 in successful immunomodulation of murine infection.
Experimental parasitology 1996;84(2):214-22.
1996: DR Brown; DJ Fowell; David B Corry; T A Wynn; NH Moskowitz; A W Cheever; Richard M Locksley; Steven L Reiner
Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.
The Journal of experimental medicine 1996;184(4):1295-304.
1996: D B Corry; Neil M Ampel; L Christian; Richard M Locksley; John N Galgiani
Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.
The Journal of infectious diseases 1996;174(2):440-3.
1996: David B Corry; Hans Folkesson; M L Warnock; David J Erle; Michael A Matthay; jeanine wiener-kronish; Richard M Locksley
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
The Journal of experimental medicine 1996;183(1):109-17.
1995: DJ Fowell; Adil E Wakil; Richard M Locksley
Interleukin-12 in murine leishmaniasis--match, flame or fuel?
Research in immunology 1995;146(7-8):566-75.
1995: Mark Bix; Richard M Locksley
Natural T cells. Cells that co-express NKRP-1 and TCR.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1020-2.
1995: Evelyne Mougneau; F Altare; Adil E Wakil; S Zheng; T Coppola; Zhi-En Wang; Rainer Waldmann; Richard M Locksley; Nicolas Glaichenhaus
Expression cloning of a protective Leishmania antigen.
Science (New York, N.Y.) 1995;268(5210):563-6.
1995: Richard M Locksley; Adil E Wakil; David B Corry; Sabine Pingel; Mark Bix; DJ Fowell
The development of effector T cell subsets in murine Leishmania major infection.
Ciba Foundation symposium 1995;195():110-7; discussion 117-22.
1995: Steven L Reiner; Richard M Locksley
The regulation of immunity to Leishmania major.
Annual review of immunology 1995;13():151-77.
1994: Zhi-En Wang; S Zheng; David B Corry; Dyana Dalton; Robert A Seder; Steven L Reiner; Richard M Locksley
Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12932-6.
1994: David B Corry; Steven L Reiner; Peter Linsley; Richard M Locksley
Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4142-8.
1994: Steven L Reiner; S Zheng; David B Corry; Richard M Locksley
Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133).
Journal of immunological methods 1994;175(2):275.
1994: Steven L Reiner; S Zheng; David B Corry; Richard M Locksley
Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46).
Journal of immunological methods 1994;173(1):133.
1994: Richard M Locksley
Th2 cells: help for helminths.
The Journal of experimental medicine 1994;179(5):1405-7.
1994: Zhi-En Wang; Steven L Reiner; S Zheng; Dyana Dalton; Richard M Locksley
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
The Journal of experimental medicine 1994;179(4):1367-71.
1994: Steven L Reiner; S Zheng; Zhi-En Wang; L Stowring; Richard M Locksley
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.
The Journal of experimental medicine 1994;179(2):447-56.
1993: B J Holaday; Margarida M L Pompeu; S Jeronimo; M J Texeira; A de A Sousa; A W Vasconcelos; Richard D Pearson; J S Abrams; Richard M Locksley
Potential role for interleukin-10 in the immunosuppression associated with kala azar.
The Journal of clinical investigation 1993;92(6):2626-32.
1993: Steven L Reiner; Richard M Locksley
Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis.
Journal of cellular biochemistry 1993;53(4):323-8.
1993: Steven L Reiner; S Zheng; David B Corry; Richard M Locksley
Constructing polycompetitor cDNAs for quantitative PCR.
Journal of immunological methods 1993;165(1):37-46.
1993: Richard M Locksley; Steven L Reiner; F Hatam; Dan R Littman; Nigel Killeen
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
Science (New York, N.Y.) 1993;261(5127):1448-51.
1993: Zhi-En Wang; Steven L Reiner; F Hatam; Frederick P Heinzel; J Bouvier; C W Turck; Richard M Locksley
Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):2077-86.
1993: Richard M Locksley
Interleukin 12 in host defense against microbial pathogens.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):5879-80.
1993: J F Tobin; Steven L Reiner; F Hatam; S Zheng; C L Leptak; Dyann F Wirth; Richard M Locksley
Transfected Leishmania expressing biologically active IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5059-69.
1993: Frederick P Heinzel; Ronald M Rerko; F Hatam; Richard M Locksley
IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):3924-31.
1993: Steven L Reiner; Zhi-En Wang; F Hatam; P Scott; Richard M Locksley
TH1 and TH2 cell antigen receptors in experimental leishmaniasis.
Science (New York, N.Y.) 1993;259(5100):1457-60.
1992: Richard M Locksley; J A Louis
Immunology of leishmaniasis.
Current opinion in immunology 1992;4(4):413-8.
1992: P Amiri; Richard M Locksley; Tristam PARSLOW; M Sadick; E Rector; D Ritter; James H McKerrow
Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice.
Nature 1992;356(6370):604-7.
1992: Steven L Reiner; Richard M Locksley
Lessons from Leishmania: a model for investigations of CD4+ subset differentiation.
Infectious agents and disease 1992;1(1):33-42.
1991: M D Sadick; N Street; T R Mosmann; Richard M Locksley
Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.
Infection and immunity 1991;59(12):4710-4.
1991: B J Holaday; M D Sadick; Zhi-En Wang; Steven L Reiner; Frederick P Heinzel; Tristam PARSLOW; Richard M Locksley
Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1653-8.
1991: Frederick P Heinzel; M D Sadick; S S Mutha; Richard M Locksley
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7011-5.
1991: M S Bernstein; S E Tong-Starksen; Richard M Locksley
Activation of human monocyte--derived macrophages with lipopolysaccharide decreases human immunodeficiency virus replication in vitro at the level of gene expression.
The Journal of clinical investigation 1991;88(2):540-5.
1991: Richard M Locksley; P Scott
Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function.
Immunology today 1991;12(3):A58-61.
1991: Richard M Locksley; Frederick P Heinzel; B J Holaday; S S Mutha; Steven L Reiner; M D Sadick
Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection.
Research in immunology 1991;142(1):28-32.
1990: M D Sadick; Frederick P Heinzel; B J Holaday; R T Pu; R S Dawkins; Richard M Locksley
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.
The Journal of experimental medicine 1990;171(1):115-27.
1989: Frederick P Heinzel; M D Sadick; B J Holaday; R L Coffman; Richard M Locksley
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.
The Journal of experimental medicine 1989;169(1):59-72.
1988: Richard M Locksley; S Crowe; M D Sadick; Frederick P Heinzel; K D Gardner; Michael S McGrath; John Mills
Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo.
The Journal of clinical investigation 1988;82(6):2097-105.
1988: R Hamadeh; A Ardehali; Richard M Locksley; M K York
Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient.
Chest 1988;94(2):432-3.
1988: Frederick P Heinzel; M D Sadick; Richard M Locksley
Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice.
Experimental parasitology 1988;65(2):258-68.
1988: Richard M Locksley; Frederick P Heinzel; J E Fankhauser; C S Nelson; M D Sadick
Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote.
Infection and immunity 1988;56(2):336-42.
1987: Richard M Locksley; Frederick P Heinzel; M D Sadick; B J Holaday; K D Gardner
Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
Annales de l'Institut Pasteur. Immunology 1987;138(5):744-9.
1987: M D Sadick; Frederick P Heinzel; V M Shigekane; W L Fisher; Richard M Locksley
Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(4):1303-9.
1987: Richard M Locksley; C S Nelson; J E Fankhauser; S J Klebanoff
Loss of granule myeloperoxidase during in vitro culture of human monocytes correlates with decay in antiprotozoa activity.
The American journal of tropical medicine and hygiene 1987;36(3):541-8.
1985: Richard M Locksley; J Fankhauser; W R Henderson
Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(20):6922-6.