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David Loeb

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Alison O'Neill; Nilay Shah; Neerav Shukla; Marc Ladanyi; David M Loeb; Aykut Uren; Naamah Zitomersky; Jeffrey A Toretsky
Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature.
Angela A Guzzetta; Craig M Hooker; David M Loeb; Heather Lyu; Christian F Meyer; Elizabeth Montgomery; Kristin L Weber; Deborah A Frassica; NITA AHUJA
Epithelioid sarcoma: one institution's experience with a rare sarcoma.
Nirali N Shah; Mitchell R Price; David M Loeb
Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma.

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All Publications

2013: Alison O'Neill; Nilay Shah; Neerav Shukla; Marc Ladanyi; David M Loeb; Aykut Uren; Naamah Zitomersky; Jeffrey A Toretsky
Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature.
Sarcoma 2013;2013():450478.
2012: Angela A Guzzetta; Craig M Hooker; David M Loeb; Heather Lyu; Christian F Meyer; Elizabeth Montgomery; Kristin L Weber; Deborah A Frassica; NITA AHUJA
Epithelioid sarcoma: one institution's experience with a rare sarcoma.
The Journal of surgical research 2012;177(1):116-22.
2012: Nirali N Shah; Mitchell R Price; David M Loeb
Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma.
Pediatric blood & cancer 2012;59(1):179-81.
2012: K M Williams; T Chung; Ronald D Cohn; Andrea M Corse; David M Loeb; Alex Mammen; L W Ostrow; Allen R Chen
Immunohistochemistry of affected tissue may guide cGVHD treatment decisions.
Bone marrow transplantation 2012;47(5):731-3.
2012: Srinivasan Senthamizhchelvan; Hong Song; Richard L Wahl; Zhe Zhang; Elwood Armour; Eric C Frey; Robert F Hobbs; David M Loeb; George Sgouros
Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acid therapy of high-risk osteosarcoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(2):215-24.
2012: Matteo Trucco; David M Loeb
Sarcoma stem cells: do we know what we are looking for?
Sarcoma 2012;2012():291705.
2011: Gregory McCarty; Ola Awad; David M Loeb
WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia.
The Journal of biological chemistry 2011;286(51):43634-43.
2011: David M Loeb
Targeted treatment in sarcoma patients.
Clinical advances in hematology & oncology : H&O 2011;9(12):934-5.
2011: Wesley Hsu; Lakesha F Johnson; Thomas A Kosztowski; David M Loeb; Edward F McCarthy; Ahmed Mohyeldin; Colette ApRhys; Ola A Awad; Ziya L Gokaslan; Neda I Sedora-Roman; Sagar R Shah; Jean-Paul Wolinsky; A QUINONES-HINOJOSA
Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.
Journal of neurosurgery 2011;115(4):760-9.
2011: Robert F Hobbs; David M Loeb; TODD MCNUTT; Sébastien Baechler; Caroline E Esaias; Eric C Frey; Bin He; ORI SHOKEK; Richard L Wahl; George Sgouros
A treatment planning method for sequentially combining radiopharmaceutical therapy and external radiation therapy.
International journal of radiation oncology, biology, physics 2011;80(4):1256-62.
2011: Amy Elizabeth Dezern; Michelle Petri; Daniel B Drachman; Douglas A Kerr; Edward R Hammond; Jeanne Kowalski; Hua-Ling Tsai; David M Loeb; Grant J Anhalt; Fredrick M Wigley; Richard J Jones; Robert A Brodsky
High-dose cyclophosphamide without stem cell rescue in 207 patients with aplastic anemia and other autoimmune diseases.
Medicine 2011;90(2):89-98.
2010: David M Loeb; Robert F Hobbs; Amarachukwu Okoli; Allen R Chen; Steve Y Cho; Senthamizhchelvan Srinivasan; George Sgouros; ORI SHOKEK; Moody D Wharam; Tammy Scott; Cindy L Schwartz
Tandem dosing of samarium-153 ethylenediamine tetramethylene phosphoric acid with stem cell support for patients with high-risk osteosarcoma.
Cancer 2010;116(23):5470-8.
2010: Ales Janda; Petr Sedlacek; Manfred Hönig; Wilhelm Friedrich; Martin Champagne; Tadashi Matsumoto; Alain Fischer; Benedicte Neven; Audrey Contet; Danielle Bensoussan; Pierre Bordigoni; David M Loeb; William J Savage; Nada Jabado; Francisco A Bonilla; Mary A Slatter; E Graham Davies; Andrew R Gennery
Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly.
Blood 2010;116(13):2229-36.
2010: Robert F Hobbs; Sébastien Baechler; Srinivasan Senthamizhchelvan; Andrew R Prideaux; Caroline E Esaias; Melvin Reinhardt; Eric C Frey; David M Loeb; George Sgouros
A gamma camera count rate saturation correction method for whole-body planar imaging.
Physics in medicine and biology 2010;55(3):817-31.
2010: Ola Awad; Jason T Yustein; Preeti Shah; Naheed Gul; Varalakshmi Katuri; Alison O'Neill; Yali Kong; Milton L Brown; Jeffrey A Toretsky; David M Loeb
High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.
PloS one 2010;5(11):e13943.
2009: Suzie A Noronha; JASON FARRAR; Todd A Alonzo; Robert B Gerbing; Norman J Lacayo; Gary V Dahl; Yaddanapudi Ravindranath; Robert J Arceci; David M Loeb
WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.
Pediatric blood & cancer 2009;53(6):1136-9.
2009: Kirsten Marie Williams; ALLISON AGWU; Alix A Dabb; Meghan A Higman; David M Loeb; Alexandra Valsamakis; Allen R Chen
A clinical algorithm identifies high risk pediatric oncology and bone marrow transplant patients likely to benefit from treatment of adenoviral infection.
Journal of pediatric hematology/oncology 2009;31(11):825-31.
2009: David M Loeb; Elizabeth Garrett-Mayer; Robert F Hobbs; Andrew R Prideaux; George Sgouros; ORI SHOKEK; Moody D Wharam; Tammy Scott; Cindy L Schwartz
Dose-finding study of 153Sm-EDTMP in patients with poor-prognosis osteosarcoma.
Cancer 2009;115(11):2514-22.
2009: David M Loeb
Is there a role for immunotherapy in osteosarcoma?
Cancer treatment and research 2009;152():447-57.
2009: Julie E Hoover-Fong; William J Savage; Emily Lisi; Jerry Winkelstein; George H Thomas; Lies Hoefsloot; David M Loeb
Congenital T cell deficiency in a patient with CHARGE syndrome.
The Journal of pediatrics 2009;154(1):140-2.
2008: David M Loeb; KATHERINE THORNTON; ORI SHOKEK
Pediatric soft tissue sarcomas.
The Surgical clinics of North America 2008;88(3):615-27, vii.
2008: Su Young Kim; Alix A Dabb; Donald J Glenn; Kristen M Snyder; Meredith K Chuk; David M Loeb
Intravenous pentamidine is effective as second line Pneumocystis pneumonia prophylaxis in pediatric oncology patients.
Pediatric blood & cancer 2008;50(4):779-83.
2007: William J Savage; Patricia A DeRusso; Linda M. Resar; Allen R Chen; Meghan A Higman; David M Loeb; Richard J Jones; Robert A Brodsky
Treatment of hepatitis-associated aplastic anemia with high-dose cyclophosphamide.
Pediatric blood & cancer 2007;49(7):947-51.
2007: Emily A Burwell; G P McCarty; L A Simpson; K A Thompson; David M Loeb
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells.
Oncogene 2007;26(23):3423-30.
2007: Suzie Ariyaratana; David M Loeb
The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis.
Expert reviews in molecular medicine 2007;9(14):1-17.
2006: Lesley A Simpson; Emily A Burwell; Kida A Thompson; Samira Shahnaz; Allen R Chen; David M Loeb
The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy.
Blood 2006;107(12):4695-702.
2006: David M Loeb
WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members.
Cell cycle (Georgetown, Tex.) 2006;5(12):1249-53.
2005: John J Strouse; MELISSA SPEVAK; A Kyle Mack; Robert J Arceci; Donald Small; David M Loeb
Significant responses to platinum-based chemotherapy in renal medullary carcinoma.
Pediatric blood & cancer 2005;44(4):407-11.
2003: David M Loeb; J L Summers; Emily A Burwell; Dorian Korz; Alan D Friedman; Saraswati Sukumar
An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation.
Leukemia 2003;17(5):965-71.
2003: Maria Oliva-Hemker; David M Loeb; Susan C Abraham; Howard M Lederman
Remission of severe autoimmune enteropathy after treatment with high-dose cyclophosphamide.
Journal of pediatric gastroenterology and nutrition 2003;36(5):639-43.
2003: Gregory Kato ; David M Loeb
Images in clinical medicine. Tumor pseudosyncytiae.
The New England journal of medicine 2003;348(14):1348.
2002: David M Loeb; D Ashley Hill; Jeffrey S Dome
Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy.
Journal of pediatric hematology/oncology 2002;24(6):478-81.
2002: David M Loeb; Saraswati Sukumar
The role of WT1 in oncogenesis: tumor suppressor or oncogene?
International journal of hematology 2002;76(2):117-26.
2002: David M Loeb; Robert J Arceci
What is the optimal therapy for childhood AML?
Oncology (Williston Park, N.Y.) 2002;16(8):1057-66; discussion 1066, 1068-70.
2002: David M Loeb; Dorian Korz; Michael Katsnelson; Emily A Burwell; Alan D Friedman; Saraswati Sukumar
Cyclin E is a target of WT1 transcriptional repression.
The Journal of biological chemistry 2002;277(22):19627-32.
2002: David M Loeb; Robert J Arceci
Treatment and outcome of infants with acute myeloid leukemia.
Blood 2002;99(7):2626-7.
2001: David M Loeb; Daniel Bowers; Curt I Civin; Alan D Friedman
Intensive timed sequential remission induction chemotherapy with high-dose cytarabine for childhood acute myeloid leukemia.
Medical and pediatric oncology 2001;37(4):365-71.
2001: Ella Evron; Christopher B Umbricht; Dorian Korz; Venu Raman; David M Loeb; B Niranjan; Lakjaya Buluwela; Sigmund A Weitzman; J Marks; Saraswati Sukumar
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation.
Cancer research 2001;61(6):2782-7.
2001: David M Loeb; Ella Evron; Chirag Patel; P M Sharma; B Niranjan; Lakjaya Buluwela; Sigmund A Weitzman; Dorian Korz; Saraswati Sukumar
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.
Cancer research 2001;61(3):921-5.
2000: David M Loeb; Howard M Lederman; Jerry A Winkelstein
Lymphoid malignancy as a presenting sign of ataxia-telangiectasia.
Journal of pediatric hematology/oncology 2000;22(5):464-7.
2000: Alister Ward; David M Loeb; AA Soede-Bobok; Ivo P Touw; Alan D Friedman
Regulation of granulopoiesis by transcription factors and cytokine signals.
Leukemia 2000;14(6):973-90.
1999: Amir A Sadighi Akha; RICHARD HUMPHREY; Jerry A Winkelstein; David M Loeb; Howard M Lederman
Oligo-/monoclonal gammopathy and hypergammaglobulinemia in ataxia-telangiectasia. A study of 90 patients.
Medicine 1999;78(6):370-81.
1998: Bengt Hallberg; M Ashcroft; David M Loeb; David R Kaplan; Julian Downward
Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.
Oncogene 1998;17(6):691-7.
1995: D Kirschenbaum; S Sieler; D Solonick; David M Loeb; R P Cody
Arthrography of the wrist. Assessment of the integrity of the ligaments in young asymptomatic adults.
The Journal of bone and joint surgery. American volume 1995;77(8):1207-9.
1994: David M Loeb; R M Stephens; T Copeland; D R Kaplan; Lloyd A Greene
A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.
The Journal of biological chemistry 1994;269(12):8901-10.
1994: R M Stephens; David M Loeb; T D Copeland; T Pawson; Lloyd A Greene; D R Kaplan
Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.
Neuron 1994;12(3):691-705.
1993: C Volonté; David M Loeb; Lloyd A Greene
A purine analog-sensitive protein kinase activity associates with Trk nerve growth factor receptors.
Journal of neurochemistry 1993;61(2):664-72.
1993: David M Loeb; Lloyd A Greene
Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(7):2919-29.
1992: David M Loeb; H Tsao; M H Cobb; Lloyd A Greene
NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk.
Neuron 1992;9(6):1053-65.
1991: David M Loeb; J Maragos; D Martin-Zanca; Moses V Chao; Luis F Parada; Lloyd A Greene
The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.
Cell 1991;66(5):961-6.
1989: C Volonté; A Rukenstein; David M Loeb; Lloyd A Greene
Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.
The Journal of cell biology 1989;109(5):2395-403.
1986: V P Terranova; E S Hujanen; David M Loeb; G R Martin; L Thornburg; V Glushko
Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):465-9.