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Lawrence Loeb

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Physiology

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Chemicals & Drugs

Living Beings

Escherichia coli

Disorders

Genes & Molecular Sequences

Amino Acid Sequence

Procedures

Genetic Complementation Test

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Co-Publications
Name
13
Kamath-Loeb, Ashwini
10
Bielas, Jason
9
Encell, Lance
9
Shen, Jiang Cheng
7
Jackson, AL
6
Rabinovitch, Peter
6
Dube, Dipak
6
Venkatesan, Ranga
5
Glick, Eitan
5
Blank, A
5
Adman, Elinor
5
Anderson, Jon
5
Newcomb, TG
5
Patel, PH
4
Landis, Daniel

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Publications

TOP 3
Schmitt Michael W; Matsumoto Yoshihiro; Loeb Lawrence A
High fidelity and lesion bypass capability of human DNA polymerase delta.
Dai Dao-Fu; Santana Luis F; Vermulst Marc; Tomazela Daniela M; Emond Mary J; MacCoss Michael J; Gollahon Katherine; Martin George M; Loeb Lawrence A; Ladiges Warren C; Rabinovitch Peter S
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.
Vermulst Marc; Bielas Jason H; Loeb Lawrence A
Quantification of random mutations in the mitochondrial genome.

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All Publications

2009: Schmitt Michael W; Matsumoto Yoshihiro; Loeb Lawrence A
High fidelity and lesion bypass capability of human DNA polymerase delta.
Biochimie 2009;91(9):1163-72.
2009: Dai Dao-Fu; Santana Luis F; Vermulst Marc; Tomazela Daniela M; Emond Mary J; MacCoss Michael J; Gollahon Katherine; Martin George M; Loeb Lawrence A; Ladiges Warren C; Rabinovitch Peter S
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.
Circulation 2009;119(21):2789-97.
2008: Vermulst Marc; Bielas Jason H; Loeb Lawrence A
Quantification of random mutations in the mitochondrial genome.
Methods (San Diego, Calif.) 2008;46(4):263-8.
2008: Chen Cheng-Yao; Guo Haiwei H; Shah Dharini; Blank A; Samson Leona D; Loeb Lawrence A
Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival.
DNA repair 2008;7(10):1731-45.
2008: Loeb Lawrence A; Harris Curtis C
Advances in chemical carcinogenesis: a historical review and prospective.
Cancer research 2008;68(17):6863-72.
2008: Compton Sarah A; Tolun Gökhan; Kamath-Loeb Ashwini S; Loeb Lawrence A; Griffith Jack D
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
The Journal of biological chemistry 2008;283(36):24478-83.
2008: Loeb Lawrence A; Bielas Jason H; Beckman Robert A
Cancers exhibit a mutator phenotype: clinical implications.
Cancer research 2008;68(10):3551-7; discussion 3557.
2008: Vermulst Marc; Wanagat Jonathan; Kujoth Gregory C; Bielas Jason H; Rabinovitch Peter S; Prolla Tomas A; Loeb Lawrence A
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
Nature genetics 2008;40(4):392-4.
2007: Venkatesan Ranga N; Treuting Piper M; Fuller Evan D; Goldsby Robert E; Norwood Thomas H; Gooley Ted A; Ladiges Warren C; Preston Bradley D; Loeb Lawrence A
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis.
Molecular and cellular biology 2007;27(21):7669-82.
2007: Camps Manel; Herman Asael; Loh Ern; Loeb Lawrence A
Genetic constraints on protein evolution.
Critical reviews in biochemistry and molecular biology 2007;42(5):313-26.
2007: Kamath-Loeb Ashwini S; Lan Li; Nakajima Satoshi; Yasui Akira; Loeb Lawrence A
Werner syndrome protein interacts functionally with translesion DNA polymerases.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10394-9.
2007: Vermulst Marc; Bielas Jason H; Kujoth Gregory C; Ladiges Warren C; Rabinovitch Peter S; Prolla Tomas A; Loeb Lawrence A
Mitochondrial point mutations do not limit the natural lifespan of mice.
Nature genetics 2007;39(4):540-3.
2007: Bielas Jason H; Venkatesan Ranga N; Loeb Lawrence A
LOH-proficient embryonic stem cells: a model of cancer progenitor cells?
Trends in genetics : TIG 2007;23(4):154-7.
2007: Loh Ern; Choe Juno; Loeb Lawrence A
Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.
The Journal of biological chemistry 2007;282(16):12201-9.
2007: Loeb Lawrence A; Bielas Jason H
Limits to the Human Cancer Genome Project?
Science (New York, N.Y.) 2007;315(5813):762; author reply 764-5.
2006: Bielas Jason H; Loeb Keith R; Rubin Brian P; True Lawrence D; Loeb Lawrence A
Human cancers express a mutator phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18238-42.
2006: Glick Eitan; White Lisa M; Elliott Nathan A; Berg Daniel; Kiviat Nancy B; Loeb Lawrence A
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.
International journal of cancer. Journal international du cancer 2006;119(9):2225-7.
2006: Venkatesan Ranga N; Bielas Jason H; Loeb Lawrence A
Generation of mutator mutants during carcinogenesis.
DNA repair 2006;5(3):294-302.
2006: Venkatesan Ranga N; Hsu Jessica J; Lawrence Nicole A; Preston Bradley D; Loeb Lawrence A
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta.
The Journal of biological chemistry 2006;281(7):4486-94.
2006: Fontes Aparecida Maria; Davis Brian M; Encell Lance P; Lingas Karen; Covas Dimas Tadeu; Zago Marco Antonio; Loeb Lawrence A; Pegg Anthony E; Gerson Stanton L
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
Molecular cancer therapeutics 2006;5(1):121-8.
2006: Hansen Alexis B; Griner Nicholas B; Anderson Jon P; Kujoth Greg C; Prolla Tomas A; Loeb Lawrence A; Glick Eitan
Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity.
DNA repair 2006;5(1):71-9.
2005: Loeb Lawrence A; Wallace Douglas C; Martin George M
The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18769-70.
2005: Loh Ern; Loeb Lawrence A
Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases.
DNA repair 2005;4(12):1390-8.
2005: Ozgenc Ali; Loeb Lawrence A
Current advances in unraveling the function of the Werner syndrome protein.
Mutation research 2005;577(1-2):237-51.
2005: Kamath-Loeb Ashwini S; Loeb Lawrence A; Masuda Yuji; Hanaoka Fumio
The first US-Japan meeting on error-prone DNA synthesis, Maui, Hawaii, December 20-21, 2004.
DNA repair 2005;4(6):740-7.
2005: Bielas Jason H; Loeb Lawrence A
Quantification of random genomic mutations.
Nature methods 2005;2(4):285-90.
2005: Bielas Jason H; Loeb Lawrence A
Mutator phenotype in cancer: timing and perspectives.
Environmental and molecular mutagenesis 2005;45(2-3):206-13.
2005: Anderson Jon P; Angerer Bernhard; Loeb Lawrence A
Incorporation of reporter-labeled nucleotides by DNA polymerases.
BioTechniques 2005;38(2):257-64.
2005: Smith Robert A; Loeb Lawrence A; Preston Bradley D
Lethal mutagenesis of HIV.
Virus research 2005;107(2):215-28.
2005: Camps Manel; Loeb Lawrence A
Critical role of R-loops in processing replication blocks.
Frontiers in bioscience : a journal and virtual library 2005;10():689-98.
2005: Venkatesan Ranga N; Loeb Lawrence A
The multiplicity of mutations in human cancers.
Advances in experimental medicine and biology 2005;570():3-17.
2004: Kamath-Loeb Ashwini S; Welcsh Piri; Waite Maureen; Adman Elinor T; Loeb Lawrence A
The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.
The Journal of biological chemistry 2004;279(53):55499-505.
2004: Sneeden Jessica L; Loeb Lawrence A
Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea.
The Journal of biological chemistry 2004;279(39):40723-8.
2004: Guo Haiwei H; Choe Juno; Loeb Lawrence A
Protein tolerance to random amino acid change.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9205-10.
2004: Blank A; Bobola Michael S; Gold Barry; Varadarajan Sridhar; D Kolstoe Douglas; Meade Elizabeth H; Rabinovitch Peter S; Loeb Lawrence A; Silber John R
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
DNA repair 2004;3(6):629-38.
2004: Camps Manel; Loeb Lawrence A
When pol I goes into high gear: processive DNA synthesis by pol I in the cell.
Cell cycle (Georgetown, Tex.) 2004;3(2):116-8.
2004: Anderson Jon P; Daifuku Richard; Loeb Lawrence A
Viral error catastrophe by mutagenic nucleosides.
Annual review of microbiology 2004;58():183-205.
2004: Khateb Samer; Weisman-Shomer Pnina; Hershco Inbal; Loeb Lawrence A; Fry Michael
Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family.
Nucleic acids research 2004;32(14):4145-54.
2003: Guo Haiwei H; Loeb Lawrence A
Tumbling down a different pathway to genetic instability.
The Journal of clinical investigation 2003;112(12):1793-5.
2003: Shen Jiang-Cheng; Loeb Lawrence A
Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site.
The Journal of biological chemistry 2003;278(47):46994-7001.
2003: Shen Jiang-Cheng; Lao Ye; Kamath-Loeb Ashwini; Wold Marc S; Loeb Lawrence A
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity.
Mechanisms of ageing and development 2003;124(8-9):921-30.
2003: Camps Manel; Naukkarinen Jussi; Johnson Ben P; Loeb Lawrence A
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9727-32.
2003: Davidson John F; Fox Richard; Harris Dawn D; Lyons-Abbott Sally; Loeb Lawrence A
Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase.
Nucleic acids research 2003;31(16):4702-9.
2003: Glick Eitan; Chau Janice S; Vigna Kellie L; McCulloch Scott D; Adman Elinor T; Kunkel Thomas A; Loeb Lawrence A
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta.
The Journal of biological chemistry 2003;278(21):19341-6.
2003: Loeb Lawrence A; Loeb Keith R; Anderson Jon P
Multiple mutations and cancer.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):776-81.
2003: Sneeden Jessica L; Loeb Lawrence A
Random oligonucleotide mutagenesis.
Methods in molecular biology (Clifton, N.J.) 2003;231():65-73.
2003: Venkatesan Ranga N; Loeb Lawrence A
Selection of novel eukaryotic DNA polymerases by mutagenesis and genetic complementation of yeast.
Methods in molecular biology (Clifton, N.J.) 2003;230():19-26.
2003: Camps Manel; Loeb Lawrence A
Use of Pol I-deficient E. coli for functional complementation of DNA polymerase.
Methods in molecular biology (Clifton, N.J.) 2003;230():11-8.
2003: Sneeden Jessica L; Loeb Lawrence A
Genetic complementation protocols.
Methods in molecular biology (Clifton, N.J.) 2003;230():3-10.
2002: Glick Eitan; Anderson Jon P; Loeb Lawrence A
In vitro production and screening of DNA polymerase eta mutants for catalytic diversity.
BioTechniques 2002;33(5):1136-42, 1144.
2002: Davidson John F; Guo Haiwei H; Loeb Lawrence A
Endogenous mutagenesis and cancer.
Mutation research 2002;509(1-2):17-21.
2002: Kawate Hisaya; Landis Daniel M; Loeb Lawrence A
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine.
The Journal of biological chemistry 2002;277(39):36304-11.
2002: Yang Qin; Zhang Ran; Wang Xin Wei; Spillare Elisa A; Linke Steven P; Subramanian Deepa; Griffith Jack D; Li Ji Liang; Hickson Ian D; Shen Jiang Cheng; Loeb Lawrence A; Mazur Sharlyn J; Appella Ettore; Brosh Robert M; Karmakar Parimal; Bohr Vilhelm A; Harris Curtis C
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
The Journal of biological chemistry 2002;277(35):31980-7.
2001: Glick E; Vigna K L; Loeb L A
Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions.
The EMBO journal 2001;20(24):7303-12.
2001: Shinkai A; Loeb L A
In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.
The Journal of biological chemistry 2001;276(50):46759-64.
2001: Shen J; Loeb L A
Unwinding the molecular basis of the Werner syndrome.
Mechanisms of ageing and development 2001;122(9):921-44.
2001: Jackson A L; Loeb L A
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer.
Mutation research 2001;477(1-2):7-21.
2001: Skandalis A; Loeb L A
Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis.
Nucleic acids research 2001;29(11):2418-26.
2001: Shinkai A; Patel P H; Loeb L A
The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable.
The Journal of biological chemistry 2001;276(22):18836-42.
2001: Patel P H; Suzuki M; Adman E; Shinkai A; Loeb L A
Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection.
Journal of molecular biology 2001;308(5):823-37.
2001: Kamath-Loeb A S; Loeb L A; Johansson E; Burgers P M; Fry M
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.
The Journal of biological chemistry 2001;276(19):16439-46.
2001: Loeb L A
A mutator phenotype in cancer.
Cancer research 2001;61(8):3230-9.
2001: Davis B M; Encell L P; Zielske S P; Christians F C; Liu L; Friebert S E; Loeb L A; Gerson S L
Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4950-4.
2001: Patel P H; Kawate H; Adman E; Ashbach M; Loeb L A
A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity.
The Journal of biological chemistry 2001;276(7):5044-51.
2001: Landis D M; Heindel C C; Loeb L A
Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.
Cancer research 2001;61(2):666-72.
2000: Patel P H; Loeb L A
Multiple amino acid substitutions allow DNA polymerases to synthesize RNA.
The Journal of biological chemistry 2000;275(51):40266-72.
2000: Uliel L; Weisman-Shomer P; Oren-Jazan H; Newcomb T; Loeb L A; Fry M
Human Ku antigen tightly binds and stabilizes a tetrahelical form of the Fragile X syndrome d(CGG)n expanded sequence.
The Journal of biological chemistry 2000;275(42):33134-41.
2000: Shen J C; Loeb L A
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.
Nucleic acids research 2000;28(17):3260-8.
2000: Encell L P; Loeb L A
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
Carcinogenesis 2000;21(7):1397-402.
2000: Patel P H; Loeb L A
DNA polymerase active site is highly mutable: evolutionary consequences.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5095-100.
2000: Shen J C; Loeb L A
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
Trends in genetics : TIG 2000;16(5):213-20.
2000: Kamath-Loeb A S; Johansson E; Burgers P M; Loeb L A
Functional interaction between the Werner Syndrome protein and DNA polymerase delta.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4603-8.
2000: Loeb K R; Loeb L A
Significance of multiple mutations in cancer.
Carcinogenesis 2000;21(3):379-85.
2000: Jackson A L; Loeb L A
Microsatellite instability induced by hydrogen peroxide in Escherichia coli.
Mutation research 2000;447(2):187-98.
1999: Abril N; Luque-Romero F L; Christians F C; Encell L P; Loeb L A; Pueyo C
Human O(6)-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes.
Carcinogenesis 1999;20(11):2089-94.
1999: Encell L P; Loeb L A
Redesigning the substrate specificity of human O(6)-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O(4)-methylthymine.
Biochemistry 1999;38(37):12097-103.
1999: Landis D M; Gerlach J L; Adman E T; Loeb L A
Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues.
Nucleic acids research 1999;27(18):3702-11.
1999: Newcomb T G; Allen K J; Tkeshelashvili L; Loeb L A
Detection of tandem CC-->TT mutations induced by oxygen radicals using mutation-specific PCR.
Mutation research 1999;427(1):21-30.
1999: Fry M; Loeb L A
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.
The Journal of biological chemistry 1999;274(18):12797-802.
1999: Encell L P; Landis D M; Loeb L A
Improving enzymes for cancer gene therapy.
Nature biotechnology 1999;17(2):143-7.
1999: Loeb L A; Essigmann J M; Kazazi F; Zhang J; Rose K D; Mullins J I
Lethal mutagenesis of HIV with mutagenic nucleoside analogs.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1492-7.
1998: Jackson A L; Loeb L A
On the origin of multiple mutations in human cancers.
Seminars in cancer biology 1998;8(6):421-9.
1998: Kamath-Loeb A S; Shen J C; Loeb L A; Fry M
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease.
The Journal of biological chemistry 1998;273(51):34145-50.
1998: Shen J C; Gray M D; Oshima J; Kamath-Loeb A S; Fry M; Loeb L A
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
The Journal of biological chemistry 1998;273(51):34139-44.
1998: Jackson A L; Chen R; Loeb L A
Induction of microsatellite instability by oxidative DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12468-73.
1998: Landis D M; Loeb L A
Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases.
The Journal of biological chemistry 1998;273(40):25809-17.
1998: Rink S M; Shen J C; Loeb L A
Creation of RNA molecules that recognize the oxidative lesion 7,8-dihydro-8-hydroxy-2'-deoxyguanosine (8-oxodG) in DNA.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11619-24.
1998: Shen J C; Gray M D; Oshima J; Loeb L A
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
Nucleic acids research 1998;26(12):2879-85.
1998: Jackson A L; Newcomb T G; Loeb L A
Origin of multiple mutations in human cancers.
Drug metabolism reviews 1998;30(2):285-304.
1998: Jackson A L; Loeb L A
The mutation rate and cancer.
Genetics 1998;148(4):1483-90.
1998: Kim B; Hathaway T R; Loeb L A
Fidelity of mutant HIV-1 reverse transcriptases: interaction with the single-stranded template influences the accuracy of DNA synthesis.
Biochemistry 1998;37(17):5831-9.
1998: Encell L P; Loeb L A
One small StEP in molecular evolution...
Nature biotechnology 1998;16(3):234-5.
1998: Encell L P; Coates M M; Loeb L A
Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis.
Cancer research 1998;58(5):1013-20.
1997: Kamath-Loeb A S; Hizi A; Tabone J; Solomon M S; Loeb L A
Inefficient repair of RNA x DNA hybrids.
European journal of biochemistry / FEBS 1997;250(2):492-501.
1997: Skandalis A; Encell L P; Loeb L A
Creating novel enzymes by applied molecular evolution.
Chemistry & biology 1997;4(12):889-98.
1997: Loeb L A
Transient expression of a mutator phenotype in cancer cells.
Science (New York, N.Y.) 1997;277(5331):1449-50.
1997: Gray M D; Shen J C; Kamath-Loeb A S; Blank A; Sopher B L; Martin G M; Oshima J; Loeb L A
The Werner syndrome protein is a DNA helicase.
Nature genetics 1997;17(1):100-3.
1997: Christians F C; Dawson B J; Coates M M; Loeb L A
Creation of human alkyltransferases resistant to O6-benzylguanine.
Cancer research 1997;57(10):2007-12.
1997: Suzuki M; Avicola A K; Hood L; Loeb L A
Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I.
The Journal of biological chemistry 1997;272(17):11228-35.
1997: Hizi A; Kamath-Loeb A S; Rose K D; Loeb L A
Mutagenesis by human immunodeficiency virus reverse transcriptase: incorporation of O6-methyldeoxyguanosine triphosphate.
Mutation research 1997;374(1):41-50.
1997: Kamath-Loeb A S; Hizi A; Kasai H; Loeb L A
Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases.
The Journal of biological chemistry 1997;272(9):5892-8.
1996: Suzuki M; Christians F C; Kim B; Skandalis A; Black M E; Loeb L A
Tolerance of different proteins for amino acid diversity.
Molecular diversity 1996;2(1-2):111-8.
1996: Suzuki M; Baskin D; Hood L; Loeb L A
Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9670-5.
1996: Ji J; Clegg N J; Peterson K R; Jackson A L; Laird C D; Loeb L A
In vitro expansion of GGC:GCC repeats: identification of the preferred strand of expansion.
Nucleic acids research 1996;24(14):2835-40.
1996: Christians F C; Loeb L A
Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6124-8.
1996: Black M E; Newcomb T G; Wilson H M; Loeb L A
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3525-9.
1996: Kim B; Hathaway T R; Loeb L A
Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli.
The Journal of biological chemistry 1996;271(9):4872-8.
1996: Loeb L A; Christians F C
Multiple mutations in human cancers.
Mutation research 1996;350(1):279-86.
1996: Black M E; Loeb L A
Random sequence mutagenesis for the generation of active enzymes.
Methods in molecular biology (Clifton, N.J.) 1996;57():335-49.
1995: Kim B; Loeb L A
A screen in Escherichia coli for nucleoside analogs that target human immunodeficiency virus (HIV) reverse transcriptase: coexpression of HIV reverse transcriptase and herpes simplex virus thymidine kinase.
Journal of virology 1995;69(10):6563-6.
1995: Christians F C; Newcomb T G; Loeb L A
Potential sources of multiple mutations in human cancers.
Preventive medicine 1995;24(4):329-32.
1995: Kim B; Loeb L A
Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):684-8.
1994: Loeb L A
Microsatellite instability: marker of a mutator phenotype in cancer.
Cancer research 1994;54(19):5059-63.
1994: Blank A; Kim B; Loeb L A
DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):9047-51.
1994: Reid T M; Feig D I; Loeb L A
Mutagenesis by metal-induced oxygen radicals.
Environmental health perspectives 1994;102 Suppl 3():57-61.
1994: Feig D I; Sowers L C; Loeb L A
Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6609-13.
1994: Chang M; Burmer G C; Sweasy J; Loeb L A; Edelhoff S; Disteche C M; Yu C E; Anderson L; Oshima J; Nakura J
Evidence against DNA polymerase beta as a candidate gene for Werner syndrome.
Human genetics 1994;93(5):507-12.
1994: Feig D I; Reid T M; Loeb L A
Reactive oxygen species in tumorigenesis.
Cancer research 1994;54(7 Suppl):1890s-1894s.
1994: Ji J; Loeb L A
Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.
Virology 1994;199(2):323-30.
1994: Feig D I; Loeb L A
Oxygen radical induced mutagenesis is DNA polymerase specific.
Journal of molecular biology 1994;235(1):33-41.
1994: Munir K M; French D C; Dube D K; Loeb L A
Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection.
Protein engineering 1994;7(1):83-9.
1994: Ji J; Hoffmann J S; Loeb L
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis.
Nucleic acids research 1994;22(1):47-52.
1993: Dube D K; Black M E; Munir K M; Loeb L A
Selection of new biologically active molecules from random nucleotide sequences.
Gene 1993;137(1):41-7.
1993: Black M E; Loeb L A
Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro.
Biochemistry 1993;32(43):11618-26.
1993: Reid T M; Loeb L A
Effect of DNA-repair enzymes on mutagenesis by oxygen free radicals.
Mutation research 1993;289(2):181-6.
1993: Tkeshelashvili L K; Reid T M; McBride T J; Loeb L A
Nickel induces a signature mutation for oxygen free radical damage.
Cancer research 1993;53(18):4172-4.
1993: Hoffmann J S; Fry M; Ji J; Williams K J; Loeb L A
Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha.
Cancer research 1993;53(12):2895-900.
1993: Sweasy J B; Loeb L A
Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4626-30.
1993: Reid T M; Loeb L A
Tandem double CC-->TT mutations are produced by reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3904-7.
1993: Munir K M; French D C; Loeb L A
Thymidine kinase mutants obtained by random sequence selection.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4012-6.
1993: Feig D I; Loeb L A
Mechanisms of mutation by oxidative DNA damage: reduced fidelity of mammalian DNA polymerase beta.
Biochemistry 1993;32(16):4466-73.
1992: McBride T J; Schneider J E; Floyd R A; Loeb L A
Mutations induced by methylene blue plus light in single-stranded M13mp2.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6866-70.
1992: Tkeshelashvili L K; McBride T; Spence K; Loeb L A
Mutation spectrum of copper-induced DNA damage.
The Journal of biological chemistry 1992;267(19):13778.
1992: Munir K M; French D C; Dube D K; Loeb L A
Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis [corrected]
The Journal of biological chemistry 1992;267(10):6584-9.
1992: Reid T M; Loeb L A
Mutagenic specificity of oxygen radicals produced by human leukemia cells.
Cancer research 1992;52(5):1082-6.
1992: Ji J P; Loeb L A
Fidelity of HIV-1 reverse transcriptase copying RNA in vitro.
Biochemistry 1992;31(4):954-8.
1992: Sweasy J B; Loeb L A
Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli.
The Journal of biological chemistry 1992;267(3):1407-10.
1992: Cheng K C; Cahill D S; Kasai H; Nishimura S; Loeb L A
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.
The Journal of biological chemistry 1992;267(1):166-72.
1991: Dube D K; Parker J D; French D C; Cahill D S; Dube S; Horwitz M S; Munir K M; Loeb L A
Artificial mutants generated by the insertion of random oligonucleotides into the putative nucleoside binding site of the HSV-1 thymidine kinase gene.
Biochemistry 1991;30(51):11760-7.
1991: Cheng K C; Preston B D; Cahill D S; Dosanjh M K; Singer B; Loeb L A
The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):9974-8.
1991: Blank A; Loeb L A
Isolation of temperature-sensitive DNA polymerase III from Saccharomyces cerevisiae cdc2-2.
Biochemistry 1991;30(32):8092-6.
1991: Loeb L A
Mutator phenotype may be required for multistage carcinogenesis.
Cancer research 1991;51(12):3075-9.
1991: Burmer G C; Rabinovitch P S; Loeb L A
Frequency and spectrum of c-Ki-ras mutations in human sporadic colon carcinoma, carcinomas arising in ulcerative colitis, and pancreatic adenocarcinoma.
Environmental health perspectives 1991;93():27-31.
1991: Tkeshelashvili L K; McBride T; Spence K; Loeb L A
Mutation spectrum of copper-induced DNA damage.
The Journal of biological chemistry 1991;266(10):6401-6.
1991: Dube D K; Horwitz M S; Loeb L A
The association of thymidine kinase activity and thymidine transport in Escherichia coli.
Gene 1991;99(1):25-9.
1991: McBride T J; Preston B D; Loeb L A
Mutagenic spectrum resulting from DNA damage by oxygen radicals.
Biochemistry 1991;30(1):207-13.
1990: Williams K J; Loeb L A; Fry M
Synthesis of DNA by human immunodeficiency virus reverse transcriptase is preferentially blocked at template oligo(deoxyadenosine) tracts.
The Journal of biological chemistry 1990;265(30):18682-9.
1990: Perrino F W; Loeb L A
Animal cell DNA polymerases in DNA repair.
Mutation research 1990;236(2-3):289-300.
1990: Perrino F W; Loeb L A
Hydrolysis of 3'-terminal mispairs in vitro by the 3'----5' exonuclease of DNA polymerase delta permits subsequent extension by DNA polymerase alpha.
Biochemistry 1990;29(22):5226-31.
1990: Loeb L A; Cheng K C
Errors in DNA synthesis: a source of spontaneous mutations.
Mutation research 1990;238(3):297-304.
1989: Perrino F W; Preston B D; Sandell L L; Loeb L A
Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8343-7.
1989: Loeb L A
Endogenous carcinogenesis: molecular oncology into the twenty-first century--presidential address.
Cancer research 1989;49(20):5489-96.
1989: Dube D K; Loeb L A
Mutants generated by the insertion of random oligonucleotides into the active site of the beta-lactamase gene.
Biochemistry 1989;28(14):5703-7.
1989: Perrino F W; Loeb L A
Proofreading by the epsilon subunit of Escherichia coli DNA polymerase III increases the fidelity of calf thymus DNA polymerase alpha.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3085-8.
1989: Burmer G C; Rabinovitch P S; Loeb L A
Analysis of c-Ki-ras mutations in human colon carcinoma by cell sorting, polymerase chain reaction, and DNA sequencing.
Cancer research 1989;49(8):2141-6.
1989: Burmer G C; Loeb L A
Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2403-7.
1989: Perrino F W; Loeb L A
Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alpha.
The Journal of biological chemistry 1989;264(5):2898-905.
1988: Preston B D; Poiesz B J; Loeb L A
Fidelity of HIV-1 reverse transcriptase.
Science (New York, N.Y.) 1988;242(4882):1168-71.
1988: Horwitz M S; Loeb L A
DNA sequences of random origin as probes of Escherichia coli promoter architecture.
The Journal of biological chemistry 1988;263(29):14724-31.
1988: Mita S; Monnat R J; Loeb L A
Resistance of HeLa cell mitochondrial DNA to mutagenesis by chemical carcinogens.
Cancer research 1988;48(16):4578-83.
1988: Horwitz M S; Loeb L A
An E. coli promoter that regulates transcription by DNA superhelix-induced cruciform extrusion.
Science (New York, N.Y.) 1988;241(4866):703-5.
1988: Preston B D; Loeb L A
Enzymatic synthesis of site-specifically modified DNA.
Mutation research 1988;200(1-2):21-35.
1988: Loeb L A; James E A; Waltersdorph A M; Klebanoff S J
Mutagenesis by the autoxidation of iron with isolated DNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3918-22.
1988: Mita S; Monnat R J; Loeb L A
Direct selection of mutations in the human mitochondrial tRNAThr gene: reversion of an 'uncloneable' phenotype.
Mutation research 1988;199(1):183-90.
1988: Reyland M E; Lehman I R; Loeb L A
Specificity of proofreading by the 3'----5' exonuclease of the DNA polymerase-primase of Drosophila melanogaster.
The Journal of biological chemistry 1988;263(14):6518-24.
1987: Preston B D; Singer B; Loeb L A
Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA.
The Journal of biological chemistry 1987;262(28):13821-7.

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