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Markus Loeffler
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43
Pfreundschuh, Michael
31
Hasenclever, Dirk
30
Diehl, Volker
22
Engel, Christoph
17
Trümper, Lorenz
15
Nijhof, W
15
Potten, Christopher
14
Schmitz, Norbert
13
Paulus, Ursula
12
Roeder, Ingo
12
Tesch, Hans
11
Rühl, Ursula
11
de Haan, Gerald
11
Dontje, Bert
10
Franklin, Jeremy
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All Publications
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2009: Scholz M; Engel C; Apt D; Sankar S L; Goldstein E; Loeffler M
Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats.
Cell proliferation 2009;42(6):823-37.
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2009: Scholz M; Ackermann M; Engel C; Emmrich F; Loeffler M; Kamprad M
A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia.
Cell proliferation 2009;42(6):813-22.
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2009: Bernd Heinz-Wolfram; Ziepert Marita; Thorns Christoph; Klapper Wolfram; Wacker Hans-Heinrich; Hummel Michael; Stein Harald; Hansmann Martin-Leo; Ott German; Rosenwald Andreas; Müller-Hermelink Hans-Konrad; Barth Thomas F E; Möller Peter; Cogliatti Sergio B; Pfreundschuh Michael; Schmitz Norbert; Trümper Lorenz; Höller Silvia; Löffler Markus; Feller Alfred C;
Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials.
Haematologica 2009;94(11):1569-80.
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2009: Marra Monica; Santini Daniele; Meo Giuseppina; Vincenzi Bruno; Zappavigna Silvia; Baldi Alfonso; Rosolowski Maciej; Tonini Giuseppe; Loeffler Markus; Lupu Ruth; Addeo Santolo Rosario; Abbruzzese Alberto; Budillon Alfredo; Caraglia Michele
Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells.
International journal of cancer. Journal international du cancer 2009;125(9):2004-13.
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2009: Engert Andreas; Diehl Volker; Franklin Jeremy; Lohri Andreas; Dörken Bernd; Ludwig Wolf-Dieter; Koch Peter; Hänel Mathias; Pfreundschuh Michael; Wilhelm Martin; Trümper Lorenz; Aulitzky Walter-Erich; Bentz Martin; Rummel Mathias; Sezer Orhan; Müller-Hermelink Hans-Konrad; Hasenclever Dirk; Löffler Markus
Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(27):4548-54.
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2009: Schoof N; von Bonin F; Zeynalova S; Ziepert M; Jung W; Loeffler M; Pfreundschuh M; Trümper L; Kube D
Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(9):1548-54.
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2009: Schmitz Norbert; Zeynalova Samira; Loeffler Markus; Pfreundschuh Michael;
Response: Intrathecal methotrexate and central nervous system events.
Blood 2009;114(9):1999-2000.
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2009: Glauche Ingmar; Moore Kateri; Thielecke Lars; Horn Katrin; Loeffler Markus; Roeder Ingo
Stem cell proliferation and quiescence--two sides of the same coin.
PLoS computational biology 2009;5(7):e1000447.
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2009: Loeffler Markus; Le'Negrate Gaelle; Krajewska Maryla; Reed John C
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth.
Cancer immunology, immunotherapy : CII 2009;58(5):769-75.
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2009: Boehme Volkmar; Schmitz Norbert; Zeynalova Samira; Loeffler Markus; Pfreundschuh Michael
CNS events in elderly patients with aggressive lymphoma treated with modern chemotherapy (CHOP-14) with or without rituximab: an analysis of patients treated in the RICOVER-60 trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).
Blood 2009;113(17):3896-902.
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2009: Martín-Subero José I; Kreuz Markus; Bibikova Marina; Bentink Stefan; Ammerpohl Ole; Wickham-Garcia Eliza; Rosolowski Maciej; Richter Julia; Lopez-Serra Lidia; Ballestar Esteban; Berger Hilmar; Agirre Xabier; Bernd Heinz-Wolfram; Calvanese Vincenzo; Cogliatti Sergio B; Drexler Hans G; Fan Jian-Bing; Fraga Mario F; Hansmann Martin L; Hummel Michael; Klapper Wolfram; Korn Bernhard; Küppers Ralf; Macleod Roderick A F; Möller Peter; Ott German; Pott Christiane; Prosper Felipe; Rosenwald Andreas; Schwaenen Carsten; Schübeler Dirk; Seifert Marc; Stürzenhofecker Benjamin; Weber Michael; Wessendorf Swen; Loeffler Markus; Trümper Lorenz; Stein Harald; Spang Rainer; Esteller Manel; Barker David; Hasenclever Dirk; Siebert Reiner;
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling.
Blood 2009;113(11):2488-97.
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2009: Schwaenen Carsten; Viardot Andreas; Berger Hilmar; Barth Thomas F E; Bentink Stefan; Döhner Hartmut; Enz Martina; Feller Alfred C; Hansmann Martin-Leo; Hummel Michael; Kestler Hans A; Klapper Wolfram; Kreuz Markus; Lenze Dido; Loeffler Markus; Möller Peter; Müller-Hermelink Hans-Konrad; Ott German; Rosolowski Maciej; Rosenwald Andreas; Ruf Sandra; Siebert Reiner; Spang Rainer; Stein Harald; Truemper Lorenz; Lichter Peter; Bentz Martin; Wessendorf Swen;
Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status.
Genes, chromosomes & cancer 2009;48(1):39-54.
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2009: Stausberg Jürgen; Löbe Matthias; Verplancke Philippe; Drepper Johannes; Herre Heinrich; Löffler Markus
Foundations of a metadata repository for databases of registers and trials.
Studies in health technology and informatics 2009;150():409-13.
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2009: Scholz Markus; Ackermann Manuela; Emmrich Frank; Loeffler Markus; Kamprad Manja
Effectiveness of cytopenia prophylaxis for different filgrastim and pegfilgrastim schedules in a chemotherapy mouse model.
Biologics : targets & therapy 2009;3():27-37.
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2008: Roeder Ingo; Horn Katrin; Sieburg Hans-Bernd; Cho Rebecca; Muller-Sieburg Christa; Loeffler Markus
Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach.
Blood 2008;112(13):4874-83.
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2008: Loeffler M; Le'Negrate G; Krajewska M; Reed J C
IL-18-producing Salmonella inhibit tumor growth.
Cancer gene therapy 2008;15(12):787-94.
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2008: Frank Bernd; Burwinkel Barbara; Bermejo Justo Lorenzo; Försti Asta; Hemminki Kari; Houlston Richard; Mangold Elisabeth; Rahner Nils; Friedl Waltraut; Friedrichs Nicolaus; Buettner Reinhard; Engel Christoph; Loeffler Markus; Holinski-Feder Elke; Morak Monika; Keller Gisela; Schackert Hans K; Krüger Stefan; Goecke Timm; Moeslein Gabriela; Kloor Matthias; Gebert Johannes; Kunstmann Erdmute; Schulmann Karsten; Rüschoff Josef; Propping Peter;
Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.
Cancer letters 2008;271(1):153-7.
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2008: Brunkhorst Frank M; Engel Christoph; Ragaller Max; Welte Tobias; Rossaint Rolf; Gerlach Herwig; Mayer Konstantin; John Stefan; Stuber Frank; Weiler Norbert; Oppert Michael; Moerer Onnen; Bogatsch Holger; Reinhart Konrad; Loeffler Markus; Hartog Christiane;
Practice and perception--a nationwide survey of therapy habits in sepsis.
Critical care medicine 2008;36(10):2719-25.
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2008: Bentink S; Wessendorf S; Schwaenen C; Rosolowski M; Klapper W; Rosenwald A; Ott G; Banham A H; Berger H; Feller A C; Hansmann M-L; Hasenclever D; Hummel M; Lenze D; Möller P; Stuerzenhofecker B; Loeffler M; Truemper L; Stein H; Siebert R; Spang R;
Pathway activation patterns in diffuse large B-cell lymphomas.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(9):1746-54.
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2008: Roehle Anja; Hoefig Kai P; Repsilber Dirk; Thorns Christoph; Ziepert Marita; Wesche Kai O; Thiere Marlen; Loeffler Markus; Klapper Wolfram; Pfreundschuh Michael; Matolcsy András; Bernd Heinz-Wolfram; Reiniger Lila; Merz Hartmut; Feller Alfred C
MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas.
British journal of haematology 2008;142(5):732-44.
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2008: Le Negrate Gaëlle; Krieg Andreas; Faustin Benjamin; Loeffler Markus; Godzik Adam; Krajewski Stan; Reed John C
ChlaDub1 of Chlamydia trachomatis suppresses NF-kappaB activation and inhibits IkappaBalpha ubiquitination and degradation.
Cellular microbiology 2008;10(9):1879-92.
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2008: Loeffler Markus; Le'Negrate Gaelle; Krajewska Maryla; Reed John C
Inhibition of tumor growth using salmonella expressing Fas ligand.
Journal of the National Cancer Institute 2008;100(15):1113-6.
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2008: Klapper Wolfram; Szczepanowski Monika; Burkhardt Birgit; Berger Hilmar; Rosolowski Maciej; Bentink Stefan; Schwaenen Carsten; Wessendorf Swen; Spang Rainer; Möller Peter; Hansmann Martin Leo; Bernd Heinz-Wolfram; Ott German; Hummel Michael; Stein Harald; Loeffler Markus; Trümper Lorenz; Zimmermann Martin; Reiter Alfred; Siebert Reiner;
Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials.
Blood 2008;112(4):1374-81.
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2008: Reinhart K; Brunkhorst F M; Engel C; Bloos F; Meier-Hellmann A; Ragaller M; Weiler N; Moerer O; Gruendling M; Oppert M; Grond S; Olthoff D; Jaschinski U; John S; Rossaint R; Welte T; Schaefer M; Kern P; Kuhnt E; Kiehntopf M; Deufel T; Hartog C; Gerlach H; Stüber F; Volk H-D; Quintel M; Loeffler M;
[Study protocol of the VISEP study. Response of the SepNet study group]
Der Anaesthesist 2008;57(7):723-8.
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2008: Kube Dieter; Hua Thanh-Duc; von Bonin Frederike; Schoof Nils; Zeynalova Samira; Klöss Marita; Gocht Daniela; Potthoff Bernd; Tzvetkov Mladen; Brockmöller Jürgen; Löffler Markus; Pfreundschuh Michael; Trümper Lorenz
Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(12):3777-84.
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2008: Elke Gunnar; Schädler Dirk; Engel Christoph; Bogatsch Holger; Frerichs Inez; Ragaller Maximilian; Scholz Jens; Brunkhorst Frank M; Löffler Markus; Reinhart Konrad; Weiler Norbert;
Current practice in nutritional support and its association with mortality in septic patients--results from a national, prospective, multicenter study.
Critical care medicine 2008;36(6):1762-7.
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2008: Pfreundschuh Michael; Ho Anthony D; Cavallin-Stahl Eva; Wolf Max; Pettengell Ruth; Vasova Ingrid; Belch Andrew; Walewski Jan; Zinzani Pier-Luigi; Mingrone Walter; Kvaloy Stein; Shpilberg Ofer; Jaeger Ulrich; Hansen Mads; Corrado Claudia; Scheliga Adriana; Loeffler Markus; Kuhnt Evelyn;
Prognostic significance of maximum tumour (bulk) diameter in young patients with good-prognosis diffuse large-B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: an exploratory analysis of the MabThera International Trial Group (MInT) study.
The lancet oncology 2008;9(5):435-44.
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2008: Dierlamm Judith; Murga Penas Eva M; Bentink Stefan; Wessendorf Swen; Berger Hilmar; Hummel Michael; Klapper Wolfram; Lenze Dido; Rosenwald Andreas; Haralambieva Eugenia; Ott German; Cogliatti Sergio B; Möller Peter; Schwaenen Carsten; Stein Harald; Löffler Markus; Spang Rainer; Trümper Lorenz; Siebert Reiner;
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma.
Haematologica 2008;93(5):688-96.
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2008: Le Negrate Gaëlle; Faustin Benjamin; Welsh Kate; Loeffler Markus; Krajewska Maryla; Hasegawa Patty; Mukherjee Sohini; Orth Kim; Krajewski Stan; Godzik Adam; Guiney Donald G; Reed John C
Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5045-56.
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2008: Ziepert M; Schmits R; Trümper L; Pfreundschuh M; Loeffler M;
Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(4):752-62.
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2008: Trümper L; Zwick C; Ziepert M; Hohloch K; Schmits R; Mohren M; Liersch R; Bentz M; Graeven U; Wruck U; Hoffmann M; Metzner B; Hasenclever D; Loeffler M; Pfreundschuh M;
Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: I. A randomized dose escalation and feasibility study with bi- and tri-weekly regimens.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(3):538-44.
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2008: Oppert Michael; Engel Christoph; Brunkhorst Frank-Martin; Bogatsch Holger; Reinhart Konrad; Frei Ulrich; Eckardt Kai-Uwe; Loeffler Markus; John Stefan;
Acute renal failure in patients with severe sepsis and septic shock--a significant independent risk factor for mortality: results from the German Prevalence Study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(3):904-9.
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2008: Pfreundschuh M; Zwick C; Zeynalova S; Dührsen U; Pflüger K-H; Vrieling T; Mesters R; Mergenthaler H-G; Einsele H; Bentz M; Lengfelder E; Trümper L; Rübe C; Schmitz N; Loeffler M;
Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: II. Results of the randomized high-CHOEP trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(3):545-52.
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2008: Stelljes Matthias; Hermann Sven; Albring Jörn; Köhler Gabriele; Löffler Markus; Franzius Christiane; Poremba Christopher; Schlösser Verena; Volkmann Sarah; Opitz Corinna; Bremer Christoph; Kucharzik Torsten; Silling Gerda; Schober Otmar; Berdel Wolfgang E; Schäfers Michael; Kienast Joachim
Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography.
Blood 2008;111(5):2909-18.
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2008: Pfreundschuh Michael; Schubert Joerg; Ziepert Marita; Schmits Rudolf; Mohren Martin; Lengfelder Eva; Reiser Marcel; Nickenig Christina; Clemens Michael; Peter Norma; Bokemeyer Carsten; Eimermacher Hartmut; Ho Anthony; Hoffmann Martin; Mertelsmann Roland; Trümper Lorenz; Balleisen Leopold; Liersch Ruediger; Metzner Bernd; Hartmann Frank; Glass Bertram; Poeschel Viola; Schmitz Norbert; Ruebe Christian; Feller Alfred C; Loeffler Markus;
Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60).
The lancet oncology 2008;9(2):105-16.
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2008: Brunkhorst Frank M; Engel Christoph; Bloos Frank; Meier-Hellmann Andreas; Ragaller Max; Weiler Norbert; Moerer Onnen; Gruendling Matthias; Oppert Michael; Grond Stefan; Olthoff Derk; Jaschinski Ulrich; John Stefan; Rossaint Rolf; Welte Tobias; Schaefer Martin; Kern Peter; Kuhnt Evelyn; Kiehntopf Michael; Hartog Christiane; Natanson Charles; Loeffler Markus; Reinhart Konrad;
Intensive insulin therapy and pentastarch resuscitation in severe sepsis.
The New England journal of medicine 2008;358(2):125-39.
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2008: Hoffmann Martin; Chang Hannah H; Huang Sui; Ingber Donald E; Loeffler Markus; Galle Joerg
Noise-driven stem cell and progenitor population dynamics.
PloS one 2008;3(8):e2922.
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2008: Horn Matthias; Loeffler Markus; Roeder Ingo
Mathematical modeling of genesis and treatment of chronic myeloid leukemia.
Cells, tissues, organs 2008;188(1-2):236-47.
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2007: Weller Michael; Berger Hilmar; Hartmann Christian; Schramm Johannes; Westphal Manfred; Simon Matthias; Goldbrunner Roland; Krex Dietmar; Steinbach Joachim P; Ostertag Christoph B; Loeffler Markus; Pietsch Torsten; von Deimling Andreas;
Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):6933-7.
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2007: Engert Andreas; Franklin Jeremy; Eich Hans Theodor; Brillant Corinne; Sehlen Susanne; Cartoni Claudio; Herrmann Richard; Pfreundschuh Michael; Sieber Markus; Tesch Hans; Franke Astrid; Koch Peter; de Wit Maike; Paulus Ursula; Hasenclever Dirk; Loeffler Markus; Müller Rolf-Peter; Müller-Hermelink Hans Konrad; Dühmke Eckhart; Diehl Volker
Two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine plus extended-field radiotherapy is superior to radiotherapy alone in early favorable Hodgkin's lymphoma: final results of the GHSG HD7 trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(23):3495-502.
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2007: Loeffler Markus; Le'Negrate Gaelle; Krajewska Maryla; Reed John C
Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12879-83.
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2007: Glauche Ingmar; Cross Michael; Loeffler Markus; Roeder Ingo
Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications.
Stem cells (Dayton, Ohio) 2007;25(7):1791-9.
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2007: Wentzensen Nicolas; Braumann Ulf-Dietrich; Einenkel Jens; Horn Lars-Christian; von Knebel Doeberitz Magnus; Löffler Markus; Kuska Jens-Peer
Combined serial section-based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(5):327-33.
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2007: Engel Christoph; Brunkhorst Frank M; Bone Hans-Georg; Brunkhorst Reinhard; Gerlach Herwig; Grond Stefan; Gruendling Matthias; Huhle Guenter; Jaschinski Ulrich; John Stefan; Mayer Konstantin; Oppert Michael; Olthoff Derk; Quintel Michael; Ragaller Max; Rossaint Rolf; Stuber Frank; Weiler Norbert; Welte Tobias; Bogatsch Holger; Hartog Christiane; Loeffler Markus; Reinhart Konrad
Epidemiology of sepsis in Germany: results from a national prospective multicenter study.
Intensive care medicine 2007;33(4):606-18.
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2007: Kube D; Hua T-D; Klöss M; Kulle B; Brockmöller J; Wojnowski L; Löffler M; Pfreundschuh M; Trümper L
The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.
Genes and immunity 2007;8(2):164-7.
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2007: Boehme V; Zeynalova S; Kloess M; Loeffler M; Kaiser U; Pfreundschuh M; Schmitz N;
Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(1):149-57.
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2007: Braumann U-D; Scherf N; Einenkel J; Horn L-C; Wentzensen N; Loeffler M; Kuska J-P
Large histological serial sections for computational tissue volume reconstruction.
Methods of information in medicine 2007;46(5):614-22.
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2007: Kreuz M; Rosolowski M; Berger H; Schwaenen C; Wessendorf S; Loeffler M; Hasenclever D
Development and implementation of an analysis tool for array-based comparative genomic hybridization.
Methods of information in medicine 2007;46(5):608-13.
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2007: Roeder Ingo; Braesel Katrin; Lorenz Ronny; Loeffler Markus
Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization.
Journal of biomedicine & biotechnology 2007;2007(3):84656.
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2006: Galle Joerg; Sittig Doreen; Hanisch Isabelle; Wobus Manja; Wandel Elke; Loeffler Markus; Aust Gabriela
Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion.
The American journal of pathology 2006;169(5):1802-11.
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2006: Tönjes Anke; Scholz Markus; Loeffler Markus; Stumvoll Michael
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.
Diabetes care 2006;29(11):2489-97.
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2006: Roeder Ingo; Horn Matthias; Glauche Ingmar; Hochhaus Andreas; Mueller Martin C; Loeffler Markus
Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications.
Nature medicine 2006;12(10):1181-4.
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2006: Goecke Timm; Schulmann Karsten; Engel Christoph; Holinski-Feder Elke; Pagenstecher Constanze; Schackert Hans K; Kloor Matthias; Kunstmann Erdmute; Vogelsang Holger; Keller Gisela; Dietmaier Wolfgang; Mangold Elisabeth; Friedrichs Nicolaus; Propping Peter; Krüger Stefan; Gebert Johannes; Schmiegel Wolff; Rueschoff Josef; Loeffler Markus; Moeslein Gabriela;
Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(26):4285-92.
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2006: Loeffler Markus; Krüger Jörg A; Niethammer Andreas G; Reisfeld Ralph A
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake.
The Journal of clinical investigation 2006;116(7):1955-62.
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2006: Hummel Michael; Bentink Stefan; Berger Hilmar; Klapper Wolfram; Wessendorf Swen; Barth Thomas F E; Bernd Heinz-Wolfram; Cogliatti Sergio B; Dierlamm Judith; Feller Alfred C; Hansmann Martin-Leo; Haralambieva Eugenia; Harder Lana; Hasenclever Dirk; Kühn Michael; Lenze Dido; Lichter Peter; Martin-Subero Jose Ignacio; Möller Peter; Müller-Hermelink Hans-Konrad; Ott German; Parwaresch Reza M; Pott Christiane; Rosenwald Andreas; Rosolowski Maciej; Schwaenen Carsten; Stürzenhofecker Benjamin; Szczepanowski Monika; Trautmann Heiko; Wacker Hans-Heinrich; Spang Rainer; Loeffler Markus; Trümper Lorenz; Stein Harald; Siebert Reiner;
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.
The New England journal of medicine 2006;354(23):2419-30.
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2006: Pfreundschuh Michael; Trümper Lorenz; Osterborg Anders; Pettengell Ruth; Trneny Marek; Imrie Kevin; Ma David; Gill Devinder; Walewski Jan; Zinzani Pier-Luigi; Stahel Rolf; Kvaloy Stein; Shpilberg Ofer; Jaeger Ulrich; Hansen Mads; Lehtinen Tuula; López-Guillermo Armando; Corrado Claudia; Scheliga Adriana; Milpied Noel; Mendila Myriam; Rashford Michelle; Kuhnt Evelyn; Loeffler Markus;
CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group.
The lancet oncology 2006;7(5):379-91.
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2006: Glass Bertram; Kloess Marita; Bentz Martin; Schlimok Günter; Berdel Wolfgang E; Feller Alfred; Trümper Lorenz; Loeffler Markus; Pfreundschuh Michael; Schmitz Norbert;
Dose-escalated CHOP plus etoposide (MegaCHOEP) followed by repeated stem cell transplantation for primary treatment of aggressive high-risk non-Hodgkin lymphoma.
Blood 2006;107(8):3058-64.
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2006: Scholz Markus; Engel Christoph; Loeffler Markus;
Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia.
British journal of haematology 2006;132(6):723-35.
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2006: Schmitz Nobert; Kloess Marita; Reiser Marcel; Berdel Wolfgang E; Metzner Bernd; Dorken Bernd; Kneba Michael; Trumper Lorenz; Loeffler Markus; Pfreundschuh Michael; Glass Bertram;
Four versus six courses of a dose-escalated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen plus etoposide (megaCHOEP) and autologous stem cell transplantation: early dose intensity is crucial in treating younger patients with poor prognosis aggressive lymphoma.
Cancer 2006;106(1):136-45.
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2006: Engel Christoph; Forberg Jochen; Holinski-Feder Elke; Pagenstecher Constanze; Plaschke Jens; Kloor Matthias; Poremba Christopher; Pox Christian P; Rüschoff Josef; Keller Gisela; Dietmaier Wolfgang; Rümmele Petra; Friedrichs Nicolaus; Mangold Elisabeth; Buettner Reinhard; Schackert Hans K; Kienle Peter; Stemmler Susanne; Moeslein Gabriela; Loeffler Markus;
Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer.
International journal of cancer. Journal international du cancer 2006;118(1):115-22.
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2005: Wojnowski Leszek; Kulle Bettina; Schirmer Markus; Schlüter Gregor; Schmidt Albrecht; Rosenberger Albert; Vonhof Stefan; Bickeböller Heike; Toliat Mohammad Reza; Suk Eun-Kyung; Tzvetkov Mladen; Kruger Anke; Seifert Silvia; Kloess Marita; Hahn Heidi; Loeffler Markus; Nürnberg Peter; Pfreundschuh Michael; Trümper Lorenz; Brockmöller Jürgen; Hasenfuss Gerd
NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity.
Circulation 2005;112(24):3754-62.
-
2005: Braumann Ulf-Dietrich; Kuska Jens-Peer; Einenkel Jens; Horn Lars-Christian; Löffler Markus; Höckel Michael
Three-dimensional reconstruction and quantification of cervical carcinoma invasion fronts from histological serial sections.
IEEE transactions on medical imaging 2005;24(10):1286-307.
-
2005: Mangold Elisabeth; Pagenstecher Constanze; Friedl Waltraut; Mathiak Micaela; Buettner Reinhard; Engel Christoph; Loeffler Markus; Holinski-Feder Elke; Müller-Koch Yvonne; Keller Gisela; Schackert Hans K; Krüger Stefan; Goecke Timm; Moeslein Gabriela; Kloor Matthias; Gebert Johannes; Kunstmann Erdmute; Schulmann Karsten; Rüschoff Josef; Propping Peter
Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.
International journal of cancer. Journal international du cancer 2005;116(5):692-702.
-
2005: Mauch Peter; Ng Andrea; Aleman Berthe; Carde Patrice; Constine Louis; Diehl Volker; Dinshaw Ketayun; Gospodarowicz Mary; Hancock Steve; Hodgson David; Hoppe Richard; Liang Raymond; Loeffler Markus; Specht Lena; Travis Lois B; Wirth Andrew; Yahalom Joachim
Report from the Rockefellar Foundation Sponsored International Workshop on reducing mortality and improving quality of life in long-term survivors of Hodgkin's disease: July 9-16, 2003, Bellagio, Italy.
European journal of haematology. Supplementum 2005;(66):68-76.
-
2005: Loeffler Markus; Krüger Jörg A; Reisfeld Ralph A
Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase.
Cancer research 2005;65(12):5027-30.
-
2005: Scholz M; Engel C; Loeffler M
Modelling human granulopoiesis under poly-chemotherapy with G-CSF support.
Journal of mathematical biology 2005;50(4):397-439.
-
2005: Ballova V; Rüffer J-U; Haverkamp H; Pfistner B; Müller-Hermelink H K; Dühmke E; Worst P; Wilhelmy M; Naumann R; Hentrich M; Eich H T; Josting A; Löffler M; Diehl V; Engert A
A prospectively randomized trial carried out by the German Hodgkin Study Group (GHSG) for elderly patients with advanced Hodgkin's disease comparing BEACOPP baseline and COPP-ABVD (study HD9elderly).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(1):124-31.
-
2005: Niethammer Andreas G; Wodrich Harald; Loeffler Markus; Lode Holger N; Emmerich Kathrin; Abdollahi Amir; Krempien Robert; Debus Juergen; Huber Peter E; Reisfeld Ralph A
Multidrug resistance-1 (MDR-1): a new target for T cell-based immunotherapy.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):158-9.
-
2005: Galle Jörg; Loeffler Markus; Drasdo Dirk
Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro.
Biophysical journal 2005;88(1):62-75.
-
2005: Roeder Ingo; Kamminga Leonie M; Braesel Katrin; Dontje Bert; de Haan Gerald; Loeffler Markus
Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization.
Blood 2005;105(2):609-16.
-
2005: Greiner U; Mueller R; Rahm E; Ramsch J; Heller B; Loeffler M
AdaptFlow: protocol-based medical treatment using adaptive workflows.
Methods of information in medicine 2005;44(1):80-8.
-
2004: Plaschke Jens; Engel Christoph; Krüger Stefan; Holinski-Feder Elke; Pagenstecher Constanze; Mangold Elisabeth; Moeslein Gabriela; Schulmann Karsten; Gebert Johannes; von Knebel Doeberitz Magnus; Rüschoff Josef; Loeffler Markus; Schackert Hans K
Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(22):4486-94.
-
2004: Engel Christoph; Scholz Markus; Loeffler Markus
A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy.
Blood 2004;104(8):2323-31.
-
2004: Pfreundschuh Michael; Trümper Lorenz; Kloess Marita; Schmits Rudolf; Feller Alfred C; Rübe Christian; Rudolph Christian; Reiser Marcel; Hossfeld Dieter K; Eimermacher Hartmut; Hasenclever Dirk; Schmitz Norbert; Loeffler Markus;
Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL.
Blood 2004;104(3):634-41.
-
2004: Pfreundschuh Michael; Trümper Lorenz; Kloess Marita; Schmits Rudolf; Feller Alfred C; Rudolph Christian; Reiser Marcel; Hossfeld Dieter K; Metzner Bernd; Hasenclever Dirk; Schmitz Norbert; Glass Bertram; Rübe Christian; Loeffler Markus;
Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL.
Blood 2004;104(3):626-33.
-
2004: Loeffler Markus; Roeder Ingo
Conceptual models to understand tissue stem cell organization.
Current opinion in hematology 2004;11(2):81-7.
-
2004: Brosteanu O; Hasenclever D; Loeffler M; Diehl V;
Low acute hematological toxicity during chemotherapy predicts reduced disease control in advanced Hodgkin's disease.
Annals of hematology 2004;83(3):176-82.
-
2004: Sieber M; Tesch H; Pfistner B; Rueffer U; Paulus U; Munker R; Hermann R; Doelken G; Koch P; Oertel J; Roller S; Worst P; Bischof H; Glunz A; Greil R; von Kalle K; Schalk K P; Hasenclever D; Brosteanu O; Duehmke E; Georgii A; Engert A; Loeffler M; Diehl V; Mueller R P; Willich N; Fischer R; Hansmann M L; Stein H; Schober T; Koch B;
Treatment of advanced Hodgkin's disease with COPP/ABV/IMEP versus COPP/ABVD and consolidating radiotherapy: final results of the German Hodgkin's Lymphoma Study Group HD6 trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(2):276-82.
-
2004: Greiner Ulrike; Ramsch Jan; Heller Barbara; Löffler Markus; Müller Robert; Rahm Erhard
Adaptive guideline-based treatment workflows with AdaptFlow.
Studies in health technology and informatics 2004;101():113-7.
-
2004: Heller B; Herre H; Lippoldt K; Loeffler M
Standardized terminology for clinical trial protocols based on top-level ontological categories.
Studies in health technology and informatics 2004;101():46-60.
-
2003: Pfistner B; Mehl C; Klöss M; Löffler M; Herrmann-Frank A; Diehl V
[Quality standards and their assurance for study centers in the competence network malignant lymphoma]
Klinische Pädiatrie 2003;215(6):341-4.
-
2003: Roeder Ingo; Loeffler Markus; Quesenberry Peter J; Colvin Gerald A; Lambert Jean-Francois
Quantitative tissue stem cell modeling.
Blood 2003;102(3):1143-4; author reply 1144-5.
-
2003: Diehl Volker; Franklin Jeremy; Pfreundschuh Michael; Lathan Bernd; Paulus Ursula; Hasenclever Dirk; Tesch Hans; Herrmann Richard; Dörken Bernd; Müller-Hermelink Hans-Konrad; Dühmke Eckhardt; Loeffler Markus;
Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin's disease.
The New England journal of medicine 2003;348(24):2386-95.
-
2003: Wunderlich A; Kloess M; Reiser M; Rudolph C; Truemper L; Bittner S; Schmalenberg H; Schmits R; Pfreundschuh M; Loeffler M;
Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(6):881-93.
-
2002: Roeder Ingo; Loeffler Markus
A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity.
Experimental hematology 2002;30(8):853-61.
-
2002: Barthel D; Meineke F A; Potten C S; Loeffler M
A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa.
Cell proliferation 2002;35 Suppl 1():48-59.
-
2002: Potten C S; Booth D; Cragg N J; Tudor G L; O'Shea J A; Booth C; Meineke F A; Barthel D; Loeffler M
Cell kinetic studies in the murine ventral tongue epithelium: mucositis induced by radiation and its protection by pretreatment with keratinocyte growth factor (KGF).
Cell proliferation 2002;35 Suppl 1():32-47.
-
2002: Potten C S; Booth D; Cragg N J; Tudor G L; O'Shea J A; Appleton D; Barthel D; Gerike T G; Meineke F A; Loeffler M; Booth C
Cell kinetic studies in the murine ventral tongue epithelium: thymidine metabolism studies and circadian rhythm determination.
Cell proliferation 2002;35 Suppl 1():1-15.
-
2002: Sieber Markus; Tesch Hans; Pfistner Beate; Rueffer Ulrich; Lathan Bernd; Brosteanu Oana; Paulus Ursula; Koch Tina; Pfreundschuh Michael; Loeffler Markus; Engert Andreas; Josting Andreas; Wolf Jürgen; Hasenclever Dirk; Franklin Jeremy; Duehmke Eckhart; Georgii Axel; Schalk Klaus-Peter; Kirchner Hartmut; Doelken Gottfried; Munker Reinhold; Koch Peter; Herrmann Richard; Greil Richard; Anselmo Anna Paola; Diehl Volker
Rapidly alternating COPP/ABV/IMEP is not superior to conventional alternating COPP/ABVD in combination with extended-field radiotherapy in intermediate-stage Hodgkin's lymphoma: final results of the German Hodgkin's Lymphoma Study Group Trial HD5.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(2):476-84.
-
2002: Loeffler Markus; Roeder Ingo
Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models--a conceptual approach.
Cells, tissues, organs 2002;171(1):8-26.
-
2001: Meineke F A; Potten C S; Loeffler M
Cell migration and organization in the intestinal crypt using a lattice-free model.
Cell proliferation 2001;34(4):253-66.
-
2001: Tinhofer I; Bernhard D; Senfter M; Anether G; Loeffler M; Kroemer G; Kofler R; Csordas A; Greil R
Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1613-5.
-
2001: Dühmke E; Franklin J; Pfreundschuh M; Sehlen S; Willich N; Rühl U; Müller R P; Lukas P; Atzinger A; Paulus U; Lathan B; Rüffer U; Sieber M; Wolf J; Engert A; Georgii A; Staar S; Herrmann R; Beykirch M; Kirchner H; Emminger A; Greil R; Fritsch E; Koch P; Drochtert A; Brosteanu O; Hasenclever D; Loeffler M; Diehl V
Low-dose radiation is sufficient for the noninvolved extended-field treatment in favorable early-stage Hodgkin's disease: long-term results of a randomized trial of radiotherapy alone.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(11):2905-14.
-
2001: Pfreundschuh M; Hasenclever D; Loeffler M; Ehninger G; Schmitz N; Kirchner H; Koch P; Lathan B; Rueffer U; Sextro M; Franklin J; Tesch H; Diehl V;
Dose escalation of cytotoxic drugs using haematopoietic growth factors: a randomized trial to determine the magnitude of increase provided by GM-CSF.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(4):471-7.
-
2001: Hasenclever D; Brosteanu O; Gerike T; Loeffler M
Modelling of chemotherapy: the effective dose approach.
Annals of hematology 2001;80 Suppl 3():B89-94.
-
2001: Rübe C; Nguyen T P; Klöss M; Loeffler M; Trümper L; Pfreunschuh M
Consolidation radiotherapy to bulky disease in aggressive NHL. First results of the NHL B-94 trial of the DSHNHL.
Annals of hematology 2001;80 Suppl 3():B84-5.
-
2001: Loeffler M; Shipp M; Stein H
2. Report on the workshop: "Clinical consequences of pathology and prognostic factors in aggressive NHL".
Annals of hematology 2001;80 Suppl 3():B8-12.
-
2001: Hasenclever D; Loeffler M
Five theses concerning the clinical consequences of pathology and prognostic factors.
Annals of hematology 2001;80 Suppl 3():B58-60.
-
2000: Engel C; Loeffler M; Schmitz S; Tesch H; Diehl V
Acute hematologic toxicity and practicability of dose-intensified BEACOPP chemotherapy for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group (GHSG).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(9):1105-14.
-
2000: Barthel D; Matthé B; Potten C S; Owen G; Loeffler M
Proliferation in murine epidermis after minor mechanical stimulation. Part 2. Alterations in keratinocyte cell cycle fluxes.
Cell proliferation 2000;33(4):247-59.
-
2000: Potten C S; Barthel D; Li Y Q; Ohlrich R; Matthé B; Loeffler M
Proliferation in murine epidermis after minor mechanical stimulation. Part 1. Sustained increase in keratinocyte production and migration.
Cell proliferation 2000;33(4):231-46.
-
2000: Mantovani L; Lentini G; Hentschel B; Wickramanayake P D; Loeffler M; Diehl V; Tesch H
Treatment of anaemia in myelodysplastic syndromes with prolonged administration of recombinant human granulocyte colony-stimulating factor and erythropoietin.
British journal of haematology 2000;109(2):367-75.
-
1999: Engel C; Loeffler M; Franke H; Schmitz S
Endogenous thrombopoietin serum levels during multicycle chemotherapy.
British journal of haematology 1999;105(3):832-8.
-
1999: Shipp M A; Abeloff M D; Antman K H; Carroll G; Hagenbeek A; Loeffler M; Montserrat E; Radford J A; Salles G; Schmitz N; Symann M; Armitage J O; Philip T; Coiffier B
International Consensus Conference on High-Dose Therapy with Hematopoietic Stem Cell Transplantation in Aggressive Non-Hodgkin's Lymphomas: report of the jury.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(1):423-9.
-
1999: Shipp M A; Abeloff M D; Antman K H; Carroll G; Hagenbeek A; Loeffler M; Montserrat E; Radford J A; Salles G; Schmitz N; Symann M; Armitage J O; Coiffier B; Philip T
International Consensus Conference on high-dose therapy with hematopoietic stem-cell transplantation in aggressive non-Hodgkin's lymphomas: report of the jury.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(1):13-9.
-
1998: Diehl V; Franklin J; Hasenclever D; Tesch H; Pfreundschuh M; Lathan B; Paulus U; Sieber M; Rueffer J U; Sextro M; Engert A; Wolf J; Hermann R; Holmer L; Stappert-Jahn U; Winnerlein-Trump E; Wulf G; Krause S; Glunz A; von Kalle K; Bischoff H; Haedicke C; Duehmke E; Georgii A; Loeffler M
BEACOPP, a new dose-escalated and accelerated regimen, is at least as effective as COPP/ABVD in patients with advanced-stage Hodgkin's lymphoma: interim report from a trial of the German Hodgkin's Lymphoma Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3810-21.
-
1998: Tesch H; Diehl V; Lathan B; Hasenclever D; Sieber M; Rüffer U; Engert A; Franklin J; Pfreundschuh M; Schalk K P; Schwieder G; Wulf G; Dölken G; Worst P; Koch P; Schmitz N; Bruntsch U; Tirier C; Müller U; Loeffler M
Moderate dose escalation for advanced stage Hodgkin's disease using the bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone scheme and adjuvant radiotherapy: a study of the German Hodgkin's Lymphoma Study Group.
Blood 1998;92(12):4560-7.
-
1998: Löffler M
[Biometrical principles in medicine]
Medizinische Klinik (Munich, Germany : 1983) 1998;93(9):571-6.
-
1998: Diehl V; Wolf J; Walshe R; Tesch H; Löffler M
[Therapy of Hodgkin's disease. Optimization over 4 study generations]
Der Internist 1998;39(9):917-26.
-
1998: Brosteanu O; Löffler M
[Methods of controlled clinical studies]
Der Internist 1998;39(9):909-16.
-
1998: Tsodikov A; Hasenclever D; Loeffler M
Regression with bounded outcome score: evaluation of power by bootstrap and simulation in a chronic myelogenous leukaemia clinical trial.
Statistics in medicine 1998;17(17):1909-22.
-
1998: Roeder I; de Haan G; Engel C; Nijhof W; Dontje B; Loeffler M
Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration.
Blood 1998;91(9):3222-9.
-
1998: Gerike T G; Paulus U; Potten C S; Loeffler M
A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.
Cell proliferation 1998;31(2):93-110.
-
1998: Loeffler M; Brosteanu O; Hasenclever D; Sextro M; Assouline D; Bartolucci A A; Cassileth P A; Crowther D; Diehl V; Fisher R I; Hoppe R T; Jacobs P; Pater J L; Pavlovsky S; Thompson E; Wiernik P
Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin's disease. International Database on Hodgkin's Disease Overview Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(3):818-29.
-
1998: Tsodikov A; Loeffler M; Yakovlev A
A cure model with time-changing risk factor: an application to the analysis of secondary leukaemia. A report from the International Database on Hodgkin's Disease.
Statistics in medicine 1998;17(1):27-40.
-
1998: Loeffler M; Hasenclever D; Diehl V
Model based development of the BEACOPP regimen for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9 Suppl 5():S73-8.
-
1998: Diehl V; Franklin J; Hasenclever D; Tesch H; Pfreundschuh M; Lathan B; Paulus U; Sieber M; Rüffer J U; Sextro M; Engert A; Wolf J; Hermann R; Holmer L; Stappert-Jahn U; Winnerlein-Trump E; Wulf G; Krause S; Glunz A; von Kalle K; Bischoff H; Haedicke C; Dühmke E; Georgii A; Loeffler M
BEACOPP: a new regimen for advanced Hodgkin's disease. German Hodgkin's Lymphoma Study Group.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9 Suppl 5():S67-71.
-
1997: Loeffler M; Diehl V; Pfreundschuh M; Rühl U; Hasenclever D; Nisters-Backes H; Sieber M; Tesch H; Franklin J; Geilen W; Bartels H; Cartoni C; Dölken G; Enzian J; Fuchs R; Gassmann W; Gerhartz H; Hagen-Aukamp U; Hiller E; Hinkelbein H; Hinterberger W; Kirchner H; Koch P; Krüger B; Schwarze E W
Dose-response relationship of complementary radiotherapy following four cycles of combination chemotherapy in intermediate-stage Hodgkin's disease.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(6):2275-87.
-
1997: Loeffler M; Bratke T; Paulus U; Li Y Q; Potten C S
Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization.
Journal of theoretical biology 1997;186(1):41-54.
-
1997: Diehl V; Sieber M; Rüffer U; Lathan B; Hasenclever D; Pfreundschuh M; Loeffler M; Lieberz D; Koch P; Adler M; Tesch H
BEACOPP: an intensified chemotherapy regimen in advanced Hodgkin's disease. The German Hodgkin's Lymphoma Study Group.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8(2):143-8.
-
1996: Schmitz S; Franke H; Loeffler M; Wichmann H E; Diehl V
Model analysis of the contrasting effects of GM-CSF and G-CSF treatment on peripheral blood neutrophils observed in three patients with childhood-onset cyclic neutropenia.
British journal of haematology 1996;95(4):616-25.
-
1996: Dühmke E; Diehl V; Loeffler M; Mueller R P; Ruehl U; Willich N; Georgii A; Roth S; Matthaei D; Sehlen S; Brosteanu O; Hasenclever D; Wilkowski R; Becker K
Randomized trial with early-stage Hodgkin's disease testing 30 Gy vs. 40 Gy extended field radiotherapy alone.
International journal of radiation oncology, biology, physics 1996;36(2):305-10.
-
1996: de Haan G; Donte B; Engel C; Loeffler M; Nijhof W
Prophylactic pretreatment of mice with hematopoietic growth factors induces expansion of primitive cell compartments and results in protection against 5-fluorouracil-induced toxicity.
Blood 1996;87(11):4581-8.
-
1996: Hofestädt R; Mavrovouniotis M; Collado-Vides J; Löffler M
Modeling and simulation of metabolic pathways, gene regulation and cell differentiation. October 22-27, 1995. International Conference and Research Center for Computer Science, Schloss Dagstuhl, Saarland, Germany.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(4):333-5.
-
1996: Hasenclever D; Loeffler M; Diehl V
Rationale for dose escalation of first line conventional chemotherapy in advanced Hodgkin's disease. German Hodgkin's Lymphoma Study Group.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7 Suppl 4():95-8.
-
1995: Diehl V; Loeffler M; Pfreundschuh M; Ruehl U; Hasenclever D; Nisters-Backes H; Sieber M; Smith K; Tesch H; Geilen W
Further chemotherapy versus low-dose involved-field radiotherapy as consolidation of complete remission after six cycles of alternating chemotherapy in patients with advance Hodgkin's disease. German Hodgkins' Study Group (GHSG).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(9):901-10.
-
1995: Dreger P; Klöss M; Petersen B; Haferlach T; Löffler H; Loeffler M; Schmitz N
Autologous progenitor cell transplantation: prior exposure to stem cell-toxic drugs determines yield and engraftment of peripheral blood progenitor cell but not of bone marrow grafts.
Blood 1995;86(10):3970-8.
-
1995: de Haan G; Dontje B; Engel C; Loeffler M; Nijhof W
The kinetics of murine hematopoietic stem cells in vivo in response to prolonged increased mature blood cell production induced by granulocyte colony-stimulating factor.
Blood 1995;86(8):2986-92.
-
1995: de Haan G; Dontje B; Engel C; Loeffler M; Nijhof W
In vivo effects of interleukin-11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis.
British journal of haematology 1995;90(4):783-90.
-
1995: Lohri A; Leyvraz S; Cerny T; Hess U; Honegger H P; Greiner R; Castiglione M; Herrmann R; Löffler M; Hasenclever D
[Participation in multicenter studies as quality control in the therapy of Hodgkin disease: an interim report]
Schweizerische medizinische Wochenschrift 1995;125(6):217-24.
-
1995: de Haan G; Dontje B; Nijhof W; Loeffler M
Effects of continuous stem cell factor administration on normal and erythropoietin-stimulated murine hemopoiesis: experimental results and model analysis.
Stem cells (Dayton, Ohio) 1995;13(1):65-76.
-
1995: de Haan G; Engel C; Dontje B; Loeffler M; Nijhof W
Hemotoxicity by prolonged etoposide administration to mice can be prevented by simultaneous growth factor therapy.
Cancer research 1995;55(2):324-9.
-
1994: Li Y Q; Roberts S A; Paulus U; Loeffler M; Potten C S
The crypt cycle in mouse small intestinal epithelium.
Journal of cell science 1994;107 ( Pt 12)():3271-9.
-
1994: de Haan G; Engel C; Dontje B; Nijhof W; Loeffler M
Mutual inhibition of murine erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colony-stimulating factor, and stem cell factor administration: in vivo interactions and dose-response surfaces.
Blood 1994;84(12):4157-63.
-
1994: Fuchs R; Löffler M; Pfreundschuh M; Dölken G; Gerhartz H; Hagen-Aukamp U; Hiller E; Petsch S; Pflüger K H; Rühl U
Prognosis of high dose chemotherapy/autologous bone marrow transplantation candidates not receiving this treatment after failure of primary therapy of Hodgkin's disease.
Leukemia & lymphoma 1994;14(1-2):79-89.
-
1994: Nijhof W; De Haan G; Dontje B; Loeffler M
Effects of G-CSF on erythropoiesis.
Annals of the New York Academy of Sciences 1994;718():312-24; discussion 324-5.
-
1993: Paulus U; Loeffler M; Zeidler J; Owen G; Potten C S
The differentiation and lineage development of goblet cells in the murine small intestinal crypt: experimental and modelling studies.
Journal of cell science 1993;106 ( Pt 2)():473-83.
-
1993: de Haan G; Dontje B; Loeffler M; Nijhof W
Microenvironmentally dependent effects on murine haemopoiesis by a prolonged interleukin-1 treatment.
British journal of haematology 1993;85(1):15-9.
-
1993: Nijhof W; Goris H; Dontje B; Dresz J; Loeffler M
Optimal erythroid cell production during erythropoietin treatment of mice occurs by exploiting the splenic microenvironment.
Experimental hematology 1993;21(4):496-501.
-
1993: Loeffler M; Birke A; Winton D; Potten C
Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt.
Journal of theoretical biology 1993;160(4):471-91.
-
1992: Paulus U; Potten C S; Loeffler M
A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation.
Cell proliferation 1992;25(6):559-78.
-
1992: Fuchs R; Löffler M; Pfreundschuh M; Dölken G; Gerhartz H; Hagen-Aukamp U; Hiller E; Petsch S; Pflüger K H; Rühl U
[Recurrence of Hodgkin's disease after advanced primary stages. German Hodgkin's Study Group]
Medizinische Klinik (Munich, Germany : 1983) 1992;87(11):555-62.
-
1992: Pfreundschuh M; Lathan B; Löffler M; Rüffer U; Hasenclever D; Diehl V
The Second International Symposium on Hodgkin's Disease. Workshop III: Recommendations for future clinical trials.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3 Suppl 4():101-4.
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1992: de Haan G; Loeffler M; Nijhof W
Long-term recombinant human granulocyte colony-stimulating factor (rhG-CSF) treatment severely depresses murine marrow erythropoiesis without causing an anemia.
Experimental hematology 1992;20(5):600-4.
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1992: Scheding S; Loeffler M; Schmitz S; Seidel H J; Wichmann H E
Hematotoxic effects of benzene analyzed by mathematical modeling.
Toxicology 1992;72(3):265-79.
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1992: Scheding S; Loeffler M; Anselstetter V; Wichmann H E
A mathematical approach to benzo[a]pyrene-induced hematotoxicity.
Archives of toxicology 1992;66(8):546-50.
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1991: Loeffler M; Grossmann B
A stochastic branching model with formation of subunits applied to the growth of intestinal crypts.
Journal of theoretical biology 1991;150(2):175-91.
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1990: Potten C S; Loeffler M
Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.
Development (Cambridge, England) 1990;110(4):1001-20.
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1990: Bungart B; Loeffler M; Goris H; Dontje B; Diehl V; Nijhof W
Differential effects of recombinant human colony stimulating factor (rh G-CSF) on stem cells in marrow, spleen and peripheral blood in mice.
British journal of haematology 1990;76(2):174-9.
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1990: Roth S L; Dühmke E; Kirschner H; Willich N; Müller R P; Bleher A; Pfreundschuh M; Löffler M; Diehl V
[Radiotherapeutic quality assurance in the Hodgkin's disease study HD4 supported by the BMFT (Bundesministerium für Forschung und Technologie)]
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1990;166(9):584-7.
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1990: Schmitz S; Loeffler M; Jones J B; Lange R D; Wichmann H E
Synchrony of bone marrow proliferation and maturation as the origin of cyclic haemopoiesis.
Cell and tissue kinetics 1990;23(5):425-42.
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1990: Pantel K; Loeffler M; Bungart B; Wichmann H E
A mathematical model of erythropoiesis in mice and rats. Part 4: Differences between bone marrow and spleen.
Cell and tissue kinetics 1990;23(4):283-97.
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1990: Goris H; Bungart B; Loeffler M; Schmitz S; Nijhof W
Migration of stem cells and progenitors between marrow and spleen following thiamphenicol treatment of mice.
Experimental hematology 1990;18(5):400-7.
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1990: Loeffler M; Pantel K
A mathematical model of erythropoiesis suggests an altered plasma volume control as cause for anemia in aged mice.
Experimental gerontology 1990;25(5):483-95.
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1990: Diehl V; Pfreundschuh M; Löffler M; Rühl U; Hiller E; Gerhartz H; Kirchner H
Cooperative trials of Hodgkin's lymphoma in the Federal Republic of Germany.
Journal of cancer research and clinical oncology 1990;116(1):106-8.
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1989: Loeffler M; Bungart B; Goris H; Schmitz S; Nijhof W
Hemopoiesis during thiamphenicol treatment. II. A theoretical analysis shows consistency of new data with a previously hypothesized model of stem cell regulation.
Experimental hematology 1989;17(9):962-7.
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1989: Goris H; Loeffler M; Bungart B; Schmitz S; Nijhof W
Hemopoiesis during thiamphenicol treatment. I. Stimulation of stem cells during eradication of intermediate cell stages.
Experimental hematology 1989;17(9):957-61.
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1989: Wulff H; Wichmann H E; Pantel K; Loeffler M
A mathematical model of erythropoiesis in mice and rats. Part 3: Suppressed erythropoiesis.
Cell and tissue kinetics 1989;22(1):51-61.
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1989: Wichmann H E; Loeffler M; Pantel K; Wulff H
A mathematical model of erythropoiesis in mice and rats. Part 2: Stimulated erythropoiesis.
Cell and tissue kinetics 1989;22(1):31-49.
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1989: Loeffler M; Pantel K; Wulff H; Wichmann H E
A mathematical model of erythropoiesis in mice and rats. Part 1: Structure of the model.
Cell and tissue kinetics 1989;22(1):13-30.
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1989: Loeffler M; Pfreundschuh M; Rühl U; Hiller E; Gerhartz H; Roloff R; Adler M; Schoppe W; Hagen-Aukamp U; Schmitt G
Risk factor adapted treatment of Hodgkin's lymphoma: strategies and perspectives.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1989;117():142-62.
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1989: Diehl V; Pfreundschuh M; Löffler M; Rühl U; Hiller E; Gerhartz H; Wilmanns W; Kirchner H; Schoppe W; Petsch S
Chemotherapy of Hodgkin's lymphoma with alternating cycles of COPP (cyclophosphamide, vincristin, procarbazine, prednisone) and ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine). Results of the HD1 and HD3 trials of the German Hodgkin Study Group.
Medical oncology and tumor pharmacotherapy 1989;6(2):155-62.
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1988: Loeffler M; Potten C S; Paulus U; Glatzer J; Chwalinski S
Intestinal crypt proliferation. II. Computer modelling of mitotic index data provides further evidence for lateral and vertical cell migration in the absence of mitotic activity.
Cell and tissue kinetics 1988;21(4):247-58.
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1988: Potten C S; Roberts S A; Chwalinski S; Loeffler M; Paulus U
Scoring mitotic activity in longitudinal sections of crypts of the small intestine.
Cell and tissue kinetics 1988;21(4):231-46.
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1988: Loeffler M; Pfreundschuh M; Hasenclever D; Hiller E; Gerhartz H; Wilmanns W; Rohloff R; Rühl U; Kühn G; Fuchs R
Prognostic risk factors in advanced Hodgkin's lymphoma. Report of the German Hodgkin Study Group.
Blut 1988;56(6):273-81.
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1988: Pfreundschuh M; Löffler M; Rühl U; Hiller E; Gerhartz H; Wilmanns W; Kirchner H; Schoppe W; Petsch S; Bartels H
[Therapy of Hodgkin's lymphomas. Results of the German Hodgkin's Disease Study Group]
Onkologie 1988;11(1):48-52.
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1988: Wichmann H E; Loeffler M; Schmitz S
A concept of hemopoietic regulation and its biomathematical realization.
Blood cells 1988;14(2-3):411-29.
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1987: Pfreundschuh M G; Schoppe W D; Fuchs R; Pflüger K H; Loeffler M; Diehl V
Lomustine, etoposide, vindesine, and dexamethasone (CEVD) in Hodgkin's lymphoma refractory to cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) and doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD): a multicenter trial of the German Hodgkin Study Group.
Cancer treatment reports 1987;71(12):1203-7.
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1987: Potten C S; Loeffler M
A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy.
Journal of theoretical biology 1987;127(4):381-91.
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1987: Diehl V; Pfreundschuh M; Löffler M; Smith K; Rühl U; Georgii A; Hiller E; Gerhartz H
[Therapy studies of the German Hodgkin's Study Group. Intermediate results of the study protocols HD1, HD2, and HD3]
Onkologie 1987;10(2):62-6.
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1987: Loeffler M; Potten C S; Wichmann H E
Epidermal cell proliferation. II. A comprehensive mathematical model of cell proliferation and migration in the basal layer predicts some unusual properties of epidermal stem cells.
Virchows Archiv. B, Cell pathology including molecular pathology 1987;53(5):286-300.
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1987: Potten C S; Loeffler M
Epidermal cell proliferation. I. Changes with time in the proportion of isolated, paired and clustered labelled cells in sheets of murine epidermis.
Virchows Archiv. B, Cell pathology including molecular pathology 1987;53(5):279-85.
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1986: Loeffler M; Stein R; Wichmann H E; Potten C S; Kaur P; Chwalinski S
Intestinal cell proliferation. I. A comprehensive model of steady-state proliferation in the crypt.
Cell and tissue kinetics 1986;19(6):627-45.
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1986: Loeffler M; Potten C S; Ditchfield A; Wichmann H E
Analysis of the changes in the proportion of clustered labelled cells in epidermis.
Cell and tissue kinetics 1986;19(4):377-89.
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1986: Diehl V; Pfreundschuh M; Hauser F E; Löffler M; Rühl U; Brücher H; Georgii A; Hiller E; Gerhartz H
[Intermediate results of therapy studies HD1, HD2 and HD3 of the German Hodgkin Study Group]
Medizinische Klinik (Munich, Germany : 1983) 1986;81(1):1-6.
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1985: Wickramanayake P D; Loeffler M; Klein H O; Groth W; Wichmann H E
Growth dependent cell proliferation kinetics of a human malignant melanoma grown in nude mice.
Journal of cancer research and clinical oncology 1985;110(1):11-6.
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1984: Loeffler M; Herkenrath P; Wichmann H E; Lord B I; Murphy M J
The kinetics of hematopoietic stem cells during and after hypoxia. A model analysis.
Blut 1984;49(6):427-39.
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1984: Wichmann H E; Loeffler M; Reincke U
The kinetics of granulopoiesis in long-term mouse bone marrow culture. Part II.
International journal of cell cloning 1984;2(6):408-24.
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1984: Reincke U; Loeffler M; Wichmann H E; Harrison B
The kinetics of granulopoiesis in long-term mouse bone marrow culture. Part I.
International journal of cell cloning 1984;2(6):394-407.
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1983: Wichmann H E; Loeffler M; Herkenrath P; Gerhardts M D; Wesselborg C; Wulff H
[Mathematical models in hematology]
Klinische Wochenschrift 1983;61(19):935-40.
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1982: Potten C S; Wichmann H E; Loeffler M; Dobek K; Major D
Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis.
Cell and tissue kinetics 1982;15(3):305-29.
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1982: Wichmann H E; Loeffler M
A solution to the controversy on stem cell regulation.
Blood cells 1982;8(2):461-5.
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1980: Loeffler M; Wichmann H E
A comprehensive mathematical model of stem cell proliferation which reproduces most of the published experimental results.
Cell and tissue kinetics 1980;13(5):543-61.
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